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1,775 results on '"Benner, Axel"'

1. Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications – a HARMONY study

Author

Hernández-Sánchez, Alberto, González, Teresa, Sobas, Marta, Sträng, Eric, Castellani, Gastone, Abáigar, María, Valk, Peter J. M., Villaverde Ramiro, Ángela, Benner, Axel, Metzeler, Klaus H., Azibeiro, Raúl, Tettero, Jesse M., Martínez-López, Joaquín, Pratcorona, Marta, Martínez Elicegui, Javier, Mills, Ken I., Thiede, Christian, Sanz, Guillermo, Döhner, Konstanze, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Reinhardt, Dirk, Schulze-Rath, Renate, Barbus, Martje, Hernández-Rivas, Jesús María, Huntly, Brian, Ossenkoppele, Gert, Döhner, Hartmut, and Bullinger, Lars

Published
2024
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2. CD8+ CD28− regulatory T cells after induction therapy predict progression-free survival in myeloma patients: results from the GMMG-HD6 multicenter phase III study

Author

Kriegsmann, Katharina, Ton, Gigi Nu Hoang Quy, Awwad, Mohamed H. S., Benner, Axel, Bertsch, Uta, Besemer, Britta, Hänel, Mathias, Fenk, Roland, Munder, Markus, Dürig, Jan, Blau, Igor W., Huhn, Stefanie, Hose, Dirk, Jauch, Anna, Mann, Christoph, Weinhold, Niels, Scheid, Christof, Schroers, Roland, von Metzler, Ivana, Schieferdecker, Aneta, Thomalla, Jörg, Reimer, Peter, Mahlberg, Rolf, Graeven, Ullrich, Kremers, Stephan, Martens, Uwe M., Kunz, Christian, Hensel, Manfred, Seidel-Glätzer, Andrea, Weisel, Katja C., Salwender, Hans J., Müller-Tidow, Carsten, Raab, Marc S., Goldschmidt, Hartmut, Mai, Elias K., and Hundemer, Michael

Published
2024
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3. When is Plasmode simulation superior to parametric simulation when estimating the MSE of the least squares estimator in linear regression?

Author

Stolte, Marieke, Schreck, Nicholas, Slynko, Alla, Saadati, Maral, Benner, Axel, Rahnenführer, Jörg, and Bommert, Andrea

Subjects
Statistics - Methodology, Statistics - Computation
Abstract

Simulation is a crucial tool for the evaluation and comparison of statistical methods. How to design fair and neutral simulation studies is therefore of great interest for researchers developing new methods and practitioners confronted with the choice of the most suitable method. The term simulation usually refers to parametric simulation, that is, computer experiments using artificial data made up of pseudo-random numbers. Plasmode simulation, that is, computer experiments using the combination of resampling feature data from a real-life dataset and generating the target variable with a known user-selected outcome-generating model (OGM), is an alternative that is often claimed to produce more realistic data. We compare parametric and Plasmode simulation for the example of estimating the mean squared error (MSE) of the least squares estimator (LSE) in linear regression. If the true underlying data-generating process (DGP) and the OGM were known, parametric simulation would obviously be the best choice in terms of estimating the MSE well. However, in reality, both are usually unknown, so researchers have to make assumptions: in Plasmode simulation for the OGM, in parametric simulation for both DGP and OGM. Most likely, these assumptions do not exactly reflect the truth. Here, we aim to find out how assumptions deviating from the true DGP and the true OGM affect the performance of parametric and Plasmode simulations in the context of MSE estimation for the LSE and in which situations which simulation type is preferable. Our results suggest that the preferable simulation method depends on many factors, including the number of features, and on how and to what extent the assumptions of a parametric simulation differ from the true DGP. Also, the resampling strategy used for Plasmode influences the results. In particular, subsampling with a small sampling proportion can be recommended.

Published
2023
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4. Statistical Plasmode Simulations -- Potentials, Challenges and Recommendations

Author

Schreck, Nicholas, Slynko, Alla, Saadati, Maral, and Benner, Axel

Subjects
Statistics - Methodology, Statistics - Applications, Statistics - Computation
Abstract

Statistical data simulation is essential in the development of statistical models and methods as well as in their performance evaluation. To capture complex data structures, in particular for high-dimensional data, a variety of simulation approaches have been introduced including parametric and the so-called plasmode simulations. While there are concerns about the realism of parametrically simulated data, it is widely claimed that plasmodes come very close to reality with some aspects of the "truth'' known. However, there are no explicit guidelines or state-of-the-art on how to perform plasmode data simulations. In the present paper, we first review existing literature and introduce the concept of statistical plasmode simulation. We then discuss advantages and challenges of statistical plasmodes and provide a step-wise procedure for their generation, including key steps to their implementation and reporting. Finally, we illustrate the concept of statistical plasmodes as well as the proposed plasmode generation procedure by means of a public real RNA dataset on breast carcinoma patients.

Published
2023

5. Clinical evaluation of complete remission (CR) with partial hematologic recovery (CRh) in acute myeloid leukemia: a report of 7235 patients from seven cohorts

Author

Appelbaum, Jacob S., Wei, Andrew H., Mandrekar, Sumithra J., Tiong, Ing S., Chua, Chong Chyn, Teh, Tse-Chieh, Fong, Chun Yew, Ting, Stephen B., Weber, Daniela, Benner, Axel, Hill, Hannah, Saadati, Maral, Yin, Jun, Stone, Richard M., Garcia-Manero, Guillermo, Erba, Harry P., Uy, Geoffrey L., Marcucci, Guido, Larson, Richard A., Thomas, Abin, Freeman, Sylvie D., Almuina, Nuria Marquez, Döhner, Konstanze, Thomas, Ian, Russel, Nigel H., Döhner, Hartmut, Othus, Megan, Estey, Elihu H., and Walter, Roland B.

Published
2024
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6. Tree-based exploratory identification of predictive biomarkers in observational data

Author

Krzykalla, Julia, Benner, Axel, and Kopp-Schneider, Annette

Subjects
Statistics - Methodology
Abstract

The idea of "stratified medicine" is an important driver of methodological research on the identification of predictive biomarkers. Most methods proposed so far for this purpose have been developed for the use on randomized data only. However, especially for rare cancers, data from clinical registries or observational studies might be the only available data source. For such data, methods for an unbiased estimation of the average treatment effect are well established. Research on confounder adjustment when investigating the heterogeneity of treatment effects and the variables responsible for this is usually restricted to regression modelling. In this paper, we demonstrate how the predMOB, a tree-based method that specifically searches for predictive factors, can be combined with common strategies for confounder adjustment (covariate adjustment, matching, Inverse Probability of Treatment Weighting (IPTW)). In an extensive simulation study, we show that covariate adjustment allows the correct identification of predictive factors in the presence of confounding whereas IPTW fails in situations in which the true predictive factor is not completely independent of the confounding mechanism. A combination of both, covariate adjustment and IPTW performs as well as covariate adjustment alone, but might be more robust in complex settings. An application to the German Breast Cancer Study Group (GBSG) Trial 2 illustrates these conclusions.

Published
2022

7. Ex vivo drug response profiling for response and outcome prediction in hematologic malignancies: the prospective non-interventional SMARTrial

Author

Liebers, Nora, Bruch, Peter-Martin, Terzer, Tobias, Hernandez-Hernandez, Miguel, Paramasivam, Nagarajan, Fitzgerald, Donnacha, Altmann, Heidi, Roider, Tobias, Kolb, Carolin, Knoll, Mareike, Lenze, Angela, Platzbecker, Uwe, Röllig, Christoph, Baldus, Claudia, Serve, Hubert, Bornhäuser, Martin, Hübschmann, Daniel, Müller-Tidow, Carsten, Stölzel, Friedrich, Huber, Wolfgang, Benner, Axel, Zenz, Thorsten, Lu, Junyan, and Dietrich, Sascha

Published
2023
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8. Clinical impact of the genomic landscape and leukemogenic trajectories in non-intensively treated elderly acute myeloid leukemia patients

Author

Jahn, Ekaterina, Saadati, Maral, Fenaux, Pierre, Gobbi, Marco, Roboz, Gail J., Bullinger, Lars, Lutsik, Pavlo, Riedel, Anna, Plass, Christoph, Jahn, Nikolaus, Walter, Claudia, Holzmann, Karlheinz, Hao, Yong, Naim, Sue, Schreck, Nicholas, Krzykalla, Julia, Benner, Axel, Keer, Harold N., Azab, Mohammad, Döhner, Konstanze, and Döhner, Hartmut

Published
2023
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12. Elotuzumab, lenalidomide, bortezomib, dexamethasone, and autologous haematopoietic stem-cell transplantation for newly diagnosed multiple myeloma (GMMG-HD6): results from a randomised, phase 3 trial

Author

Adrian, Nicole, Bernhard, Helga, Böck, Hans-Peter, Bolling, Claus, Dingeldein, Gerrit, Emde, Till-Oliver, Ferstl, Barbara, Fietz, Thomas, Fronhoffs, Stefan, Fuhrmann, Stephan, Fuxius, Stefan, Geer, Thomas, Görner, Martin, Guenther, Barbara, Hartmann, Frank, Heilmeier, Bernhard, Heinsch, Michael, Hoffmann, Martin, Holderried, Tobias A.W., Klein, Stefan, Klump, Martin, Knauf, Wolfgang, La Rosée, Paul, Lange, Elisabeth, Lindemann, Walter, Lopez, Roderico, Mayer, Frank, Nückel, Holger, Papesch, Eva, Procaccianti, Maria, Reichart, Alexander, Rummel, Mathias, Scheuer, Lars, Schmitt, Hans-Roland, Staib, Peter, Steiniger, Heike, Tischler, Hans-Joachim, Ulshöfer, Thomas, Verbeek, Walter, Wacker, Alexander, Zirpel, Iris, Mai, Elias K, Goldschmidt, Hartmut, Miah, Kaya, Bertsch, Uta, Besemer, Britta, Hänel, Mathias, Krzykalla, Julia, Fenk, Roland, Schlenzka, Jana, Munder, Markus, Dürig, Jan, Blau, Igor W, Huhn, Stefanie, Hose, Dirk, Jauch, Anna, Kunz, Christina, Mann, Christoph, Weinhold, Niels, Scheid, Christof, Schroers, Roland, von Metzler, Ivana, Schieferdecker, Aneta, Thomalla, Jörg, Reimer, Peter, Mahlberg, Rolf, Graeven, Ullrich, Kremers, Stephan, Martens, Uwe M, Kunz, Christian, Hensel, Manfred, Benner, Axel, Seidel-Glätzer, Andrea, Weisel, Katja C, Raab, Marc S, and Salwender, Hans J

Published
2024
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13. Multiparametric Magnetic Resonance Imaging in Prostate Cancer Screening at the Age of 45 Years: Results from the First Screening Round of the PROBASE Trial

Author

Boschheidgen, Matthias, Albers, Peter, Schlemmer, Heinz-Peter, Hellms, Susanne, Bonekamp, David, Sauter, Andreas, Hadaschik, Boris, Krilaviciute, Agne, Radtke, Jan Philipp, Seibold, Petra, Lakes, Jale, Arsov, Christian, Gschwend, Jürgen E., Herkommer, Kathleen, Makowski, Marcus, Kuczyk, Markus A., Wacker, Frank, Harke, Nina, Debus, Jürgen, Körber, Stefan A., Benner, Axel, Kristiansen, Glen, Giesel, Frederik L., Antoch, Gerald, Kaaks, Rudolf, Becker, Nikolaus, and Schimmöller, Lars

Published
2024
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14. Risk-adjusted Screening for Prostate Cancer—Defining the Low-risk Group by Data from the PROBASE Trial

Author

Krilaviciute, Agne, Kaaks, Rudolf, Seibold, Petra, de Vrieze, Maxime, Lakes, Jale, Radtke, Jan Philipp, Kuczyk, Markus, Harke, Nina N., Debus, Jürgen, Fink, Christoph A., Herkommer, Kathleen, Gschwend, Jürgen E., Meissner, Valentin H., Benner, Axel, Kristiansen, Glen, Hadaschik, Boris, Arsov, Christian, Schimmöller, Lars, Antoch, Gerald, Giesel, Frederik L., Makowski, Marcus, Wacker, Frank, Schlemmer, Heinz-Peter, Becker, Nikolaus, and Albers, Peter

Published
2024
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15. Correction: Clinical impact of the genomic landscape and leukemogenic trajectories in non-intensively treated elderly acute myeloid leukemia patients

Author

Jahn, Ekaterina, Saadati, Maral, Fenaux, Pierre, Gobbi, Marco, Roboz, Gail J., Bullinger, Lars, Lutsik, Pavlo, Riedel, Anna, Plass, Christoph, Jahn, Nikolaus, Walter, Claudia, Holzmann, Karlheinz, Hao, Yong, Naim, Sue, Schreck, Nicholas, Krzykalla, Julia, Benner, Axel, Keer, Harold N., Azab, Mohammad, Döhner, Konstanze, and Döhner, Hartmut

Published
2023
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16. Digital Rectal Examination Is Not a Useful Screening Test for Prostate Cancer

Author

Krilaviciute, Agne, Becker, Nikolaus, Lakes, Jale, Radtke, Jan Philipp, Kuczyk, Markus, Peters, Inga, Harke, Nina N., Debus, Jürgen, Koerber, Stefan A., Herkommer, Kathleen, Gschwend, Jürgen E., Meissner, Valentin H., Benner, Axel, Seibold, Petra, Kristiansen, Glen, Hadaschik, Boris, Arsov, Christian, Schimmöller, Lars, Giesel, Frederik Lars, Antoch, Gerald, Makowski, Marcus, Wacker, Frank, Schlemmer, Heinz-Peter, Kaaks, Rudolf, and Albers, Peter

Published
2023
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17. Intensive chemotherapy with or without gemtuzumab ozogamicin in patients with NPM1-mutated acute myeloid leukaemia (AMLSG 09–09): a randomised, open-label, multicentre, phase 3 trial

Author

Döhner, Hartmut, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Kühn, Michael W.M., Schroeder, Thomas, Mayer, Karin, Lübbert, Michael, Wattad, Mohammad, Götze, Katharina, Fransecky, Lars, Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Ringhoffer, Mark, Greil, Richard, Hertenstein, Bernd, Krauter, Jürgen, Martens, Uwe M., Nachbaur, David, Samra, Maisun Abu, Machherndl-Spandl, Sigrid, Basara, Nadezda, Leis, Claudia, Schrade, Anika, Kapp-Schwoerer, Silke, Cocciardi, Sibylle, Bullinger, Lars, Thol, Felicitas, Heuser, Michael, Paschka, Peter, Gaidzik, Verena I., Saadati, Maral, Benner, Axel, Schlenk, Richard F., Döhner, Konstanze, Ganser, Arnold, Kühn, Michael W M, Wattad, Mohammed, Martens, Uwe M, Gaidzik, Verena I, and Schlenk, Richard F

Published
2023
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18. Genomic landscape of patients with FLT3-mutated acute myeloid leukemia (AML) treated within the CALGB 10603/RATIFY trial

Author

Jahn, Nikolaus, Jahn, Ekaterina, Saadati, Maral, Bullinger, Lars, Larson, Richard A., Ottone, Tiziana, Amadori, Sergio, Prior, Thomas W., Brandwein, Joseph M., Appelbaum, Frederick R., Medeiros, Bruno C., Tallman, Martin S., Ehninger, Gerhard, Heuser, Michael, Ganser, Arnold, Pallaud, Celine, Gathmann, Insa, Krzykalla, Julia, Benner, Axel, Bloomfield, Clara D., Thiede, Christian, Stone, Richard M., Döhner, Hartmut, and Döhner, Konstanze

Published
2022
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21. Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications

Author

Döhner, Hartmut, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Wulf, Gerald, Salih, Helmut, Lübbert, Michael, Kühn, Michael W.M., Schroeder, Thomas, Salwender, Hans, Götze, Katharina, Westermann, Jörg, Fransecky, Lars, Mayer, Karin, Hertenstein, Bernd, Ringhoffer, Mark, Tischler, Hans-Joachim, Machherndl-Spandl, Sigrid, Schrade, Anika, Paschka, Peter, Gaidzik, Verena I., Theis, Frauke, Thol, Felicitas, Heuser, Michael, Schlenk, Richard F., Bullinger, Lars, Saadati, Maral, Benner, Axel, Larson, Richard, Stone, Richard, Döhner, Konstanze, and Ganser, Arnold

Published
2022
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23. Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) in front-line treatment of high-risk multiple myeloma: interim analysis of the GMMG-CONCEPT trial

Author

Leypoldt, Lisa B., Besemer, Britta, Asemissen, Anne Marie, Hänel, Mathias, Blau, Igor Wolfgang, Görner, Martin, Ko, Yon-Dschun, Reinhardt, Hans Christian, Staib, Peter, Mann, Christoph, Lutz, Raphael, Munder, Markus, Graeven, Ullrich, Peceny, Rudolf, Salwender, Hans, Jauch, Anna, Zago, Manola, Benner, Axel, Tichy, Diana, Bokemeyer, Carsten, Goldschmidt, Hartmut, and Weisel, Katja C.

Published
2022
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24. Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results

Author

Rücker, Frank G., Du, Ling, Luck, Tamara J., Benner, Axel, Krzykalla, Julia, Gathmann, Insa, Voso, Maria Teresa, Amadori, Sergio, Prior, Thomas W., Brandwein, Joseph M., Appelbaum, Frederick R., Medeiros, Bruno C., Tallman, Martin S., Savoie, Lynn, Sierra, Jorge, Pallaud, Celine, Sanz, Miguel A., Jansen, Joop H., Niederwieser, Dietger, Fischer, Thomas, Ehninger, Gerhard, Heuser, Michael, Ganser, Arnold, Bullinger, Lars, Larson, Richard A., Bloomfield, Clara D., Stone, Richard M., Döhner, Hartmut, Thiede, Christian, and Döhner, Konstanze

Published
2022
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25. Measures of hydroxymethylation

Author

Slynko, Alla and Benner, Axel

Subjects
Quantitative Biology - Quantitative Methods, Quantitative Biology - Genomics, Statistics - Applications
Abstract

Hydroxymethylcytosine (5hmC) methylation is known to be a possible epigenetic mark impacting genome stability. In this paper, we address the existing 5hmC measure $\Delta \beta$ and discuss its properties both analytically and empirically on real data. Then we introduce several alternative hydroxymethylation measures and compare their properties with those of $\Delta \beta$. All results will be illustrated by means of real data analyses.

Published
2017

26. Long-term follow-up of subcutaneous versus intravenous bortezomib during induction therapy for newly diagnosed multiple myeloma treated within the GMMG-MM5 Phase III Trial

Author

Salwender, Hans, Elmaagacli, Ahmet, Merz, Maximilian, Miah, Kaya, Benner, Axel, Haenel, Mathias, Jehn, Christian, Mai, Elias K., Bertsch, Uta, Blau, Igor W., Scheid, Christof, Hose, Dirk, Seckinger, Anja, Jauch, Anna, Raab, Marc S., Luntz, Steffen P., Besemer, Britta, Munder, Markus, Brossart, Peter, Fuhrmann, Stephan, Lindemann, Hans-Walter, Weisel, Katja, Duerig, Jan, and Goldschmidt, Hartmut

Published
2021
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27. DNA methylation-based classification of central nervous system tumours.

Author

Capper, David, Jones, David TW, Sill, Martin, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik, Koelsche, Christian, Sahm, Felix, Chavez, Lukas, Reuss, David E, Kratz, Annekathrin, Wefers, Annika K, Huang, Kristin, Pajtler, Kristian W, Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W, Lindenberg, Kerstin, Harter, Patrick N, Braczynski, Anne K, Plate, Karl H, Dohmen, Hildegard, Garvalov, Boyan K, Coras, Roland, Hölsken, Annett, Hewer, Ekkehard, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora, Giangaspero, Felice, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J, Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Jürgen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri, Tsirigos, Aristotelis, Brück, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R, Kohlhof, Patricia, Kristensen, Bjarne W, Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Mühleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc, Gottardo, Nicholas G, Driever, Pablo Hernáiz, Kramm, Christof M, Müller, Hermann L, Rutkowski, Stefan, von Hoff, Katja, Frühwald, Michael C, Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia-Maria, Perry, Arie, and Jones, Chris

Subjects
Humans, Central Nervous System Neoplasms, Cohort Studies, Reproducibility of Results, DNA Methylation, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Infant, Female, Male, Young Adult, Unsupervised Machine Learning, and over, Preschool, General Science & Technology
Abstract

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.

Published
2018

29. Elotuzumab, lenalidomide, bortezomib, dexamethasone, and autologous haematopoietic stem-cell transplantation for newly diagnosed multiple myeloma (GMMG-HD6): results from a randomised, phase 3 trial

Author

Mai, Elias K, primary, Goldschmid, Hartmut, additional, Miah, Kaya, additional, Bertsch, Uta, additional, Besemer, Britta, additional, Hänel, Mathias, additional, Krzykalla, Julia, additional, Fenk, Roland, additional, Schlenzka, Jana, additional, Munder, Markus, additional, Dürig, Jan, additional, Blau, Igor W, additional, Huhn, Stefanie, additional, Hose, Dirk, additional, Jauch, Anna, additional, Kunz, Christina, additional, Mann, Christoph, additional, Weinhold, Niels, additional, Scheid, Christof, additional, Schroers, Roland, additional, von Metzler, Ivana, additional, Schieferdecker, Aneta, additional, Thomalla, Jörg, additional, Reimer, Peter, additional, Mahlberg, Rolf, additional, Graeven, Ullrich, additional, Kremers, Stephan, additional, Martens, Uwe M, additional, Kunz, Christian, additional, Hensel, Manfred, additional, Benner, Axel, additional, Seidel-Glätzer, Andrea, additional, Weisel, Katja C, additional, Raab, Marc S, additional, Salwender, Hans J, additional, Adrian, Nicole, additional, Bernhard, Helga, additional, Böck, Hans-Peter, additional, Bolling, Claus, additional, Dingeldein, Gerrit, additional, Emde, Till-Oliver, additional, Ferstl, Barbara, additional, Fietz, Thomas, additional, Fronhoffs, Stefan, additional, Fuhrmann, Stephan, additional, Fuxius, Stefan, additional, Geer, Thomas, additional, Görner, Martin, additional, Guenther, Barbara, additional, Hartmann, Frank, additional, Heilmeier, Bernhard, additional, Heinsch, Michael, additional, Hoffmann, Martin, additional, Holderried, Tobias A.W., additional, Klein, Stefan, additional, Klump, Martin, additional, Knauf, Wolfgang, additional, La Rosée, Paul, additional, Lange, Elisabeth, additional, Lindemann, Walter, additional, Lopez, Roderico, additional, Mayer, Frank, additional, Nückel, Holger, additional, Papesch, Eva, additional, Procaccianti, Maria, additional, Reichart, Alexander, additional, Rummel, Mathias, additional, Scheuer, Lars, additional, Schmitt, Hans-Roland, additional, Staib, Peter, additional, Steiniger, Heike, additional, Tischler, Hans-Joachim, additional, Ulshöfer, Thomas, additional, Verbeek, Walter, additional, Wacker, Alexander, additional, and Zirpel, Iris, additional

Published
2024
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30. Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study

Author

Penack, Olaf, primary, Luft, Thomas, additional, Peczynski, Christophe, additional, Benner, Axel, additional, Sica, Simona, additional, Arat, Mutlu, additional, Itäla-Remes, Maija, additional, Corral, Lucia López, additional, Schaap, Nicolaas P M, additional, Karas, Michal, additional, Raida, Ludek, additional, Schroeder, Thomas, additional, Dreger, Peter, additional, Metafuni, Elisabetta, additional, Ozcelik, Tulay, additional, Sandmaier, Brenda M, additional, Kordelas, Lambros, additional, Moiseev, Ivan, additional, Schoemans, Hélène, additional, Koenecke, Christian, additional, Basak, Grzegorz W, additional, and Peric, Zinaida, additional

Published
2024
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32. Selective elimination of immunosuppressive T cells in patients with multiple myeloma

Author

Awwad, Mohamed H. S., Mahmoud, Abdelrahman, Bruns, Heiko, Echchannaoui, Hakim, Kriegsmann, Katharina, Lutz, Raphael, Raab, Marc S., Bertsch, Uta, Munder, Markus, Jauch, Anna, Weisel, Katja, Maier, Bettina, Weinhold, Niels, Salwender, Hans Jürgen, Eckstein, Volker, Hänel, Mathias, Fenk, Roland, Dürig, Jan, Brors, Benedikt, Benner, Axel, Müller-Tidow, Carsten, Goldschmidt, Hartmut, and Hundemer, Michael

Published
2021
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33. CD8+CD28−regulatory T cells after induction therapy predict progression-free survival in myeloma patients: results from the GMMG-HD6 multicenter phase III study

Author

Kriegsmann, Katharina, Ton, Gigi Nu Hoang Quy, Awwad, Mohamed H. S., Benner, Axel, Bertsch, Uta, Besemer, Britta, Hänel, Mathias, Fenk, Roland, Munder, Markus, Dürig, Jan, Blau, Igor W., Huhn, Stefanie, Hose, Dirk, Jauch, Anna, Mann, Christoph, Weinhold, Niels, Scheid, Christof, Schroers, Roland, von Metzler, Ivana, Schieferdecker, Aneta, Thomalla, Jörg, Reimer, Peter, Mahlberg, Rolf, Graeven, Ullrich, Kremers, Stephan, Martens, Uwe M., Kunz, Christian, Hensel, Manfred, Seidel-Glätzer, Andrea, Weisel, Katja C., Salwender, Hans J., Müller-Tidow, Carsten, Raab, Marc S., Goldschmidt, Hartmut, Mai, Elias K., and Hundemer, Michael

Published
2024
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34. Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial

Author

Kapp-Schwoerer, Silke, Weber, Daniela, Corbacioglu, Andrea, Gaidzik, Verena I., Paschka, Peter, Krönke, Jan, Theis, Frauke, Rücker, Frank G., Teleanu, Maria-Veronica, Panina, Ekaterina, Jahn, Nikolaus, Herzig, Julia, Kubanek, Lena, Schrade, Anika, Göhring, Gudrun, Fiedler, Walter, Kindler, Thomas, Schroeder, Thomas, Mayer, Karin T., Lübbert, Michael, Wattad, Mohammed, Götze, Katharina S., Horst, Heinz A., Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Bentz, Martin, Krauter, Jürgen, Bullinger, Lars, Krzykalla, Julia, Benner, Axel, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, and Döhner, Konstanze

Published
2020
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35. Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication

Author

Jahn, Nikolaus, Terzer, Tobias, Sträng, Eric, Dolnik, Anna, Cocciardi, Sibylle, Panina, Ekaterina, Corbacioglu, Andrea, Herzig, Julia, Weber, Daniela, Schrade, Anika, Götze, Katharina, Schröder, Thomas, Lübbert, Michael, Wellnitz, Dominique, Koller, Elisabeth, Schlenk, Richard F., Gaidzik, Verena I., Paschka, Peter, Rücker, Frank G., Heuser, Michael, Thol, Felicitas, Ganser, Arnold, Benner, Axel, Döhner, Hartmut, Bullinger, Lars, and Döhner, Konstanze

Published
2020
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36. Genome-Wide DNA Methylation Profiling in Early Stage I Lung Adenocarcinoma Reveals Predictive Aberrant Methylation in the Promoter Region of the Long Noncoding RNA PLUT: An Exploratory Study

Author

Kim-Wanner, Soo-Zin, Assenov, Yassen, Nair, Mridul B., Weichenhan, Dieter, Benner, Axel, Becker, Natalia, Landwehr, Katharina, Kuner, Ruprecht, Sültmann, Holger, Esteller, Manel, Koch, Ina, Lindner, Michael, Meister, Michael, Thomas, Michael, Bieg, Matthias, Klingmüller, Ursula, Schlesner, Matthias, Warth, Arne, Brors, Benedikt, Seifried, Erhard, Bönig, Halvard, Plass, Christoph, Risch, Angela, and Muley, Thomas

Published
2020
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37. Multiparametric Magnetic Resonance Imaging in Prostate Cancer Screening at the Age of 45 Years: Results from the First Screening Round of the PROBASE Trial

Author

Boschheidgen, Matthias, primary, Albers, Peter, additional, Schlemmer, Heinz-Peter, additional, Hellms, Susanne, additional, Bonekamp, David, additional, Sauter, Andreas, additional, Hadaschik, Boris, additional, Krilaviciute, Agne, additional, Radtke, Jan Philipp, additional, Seibold, Petra, additional, Lakes, Jale, additional, Arsov, Christian, additional, Gschwend, Jürgen E., additional, Herkommer, Kathleen, additional, Makowski, Marcus, additional, Kuczyk, Markus A., additional, Wacker, Frank, additional, Harke, Nina, additional, Debus, Jürgen, additional, Körber, Stefan A., additional, Benner, Axel, additional, Kristiansen, Glen, additional, Giesel, Frederik L., additional, Antoch, Gerald, additional, Kaaks, Rudolf, additional, Becker, Nikolaus, additional, and Schimmöller, Lars, additional

Published
2023
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38. Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia

Author

Bloehdorn, Johannes, Braun, Andrejs, Taylor-Weiner, Amaro, Jebaraj, Billy Michael Chelliah, Robrecht, Sandra, Krzykalla, Julia, Pan, Heng, Giza, Adam, Akylzhanova, Gulnara, Holzmann, Karlheinz, Scheffold, Annika, Johnston, Harvey E., Yeh, Ru-Fang, Klymenko, Tetyana, Tausch, Eugen, Eichhorst, Barbara, Bullinger, Lars, Fischer, Kirsten, Weisser, Martin, Robak, Tadeusz, Schneider, Christof, Gribben, John, Dahal, Lekh N., Carter, Mathew J., Elemento, Olivier, Landau, Dan A., Neuberg, Donna S., Cragg, Mark S., Benner, Axel, Hallek, Michael, Wu, Catherine J., Döhner, Hartmut, Stilgenbauer, Stephan, and Mertens, Daniel

Published
2021
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39. Time-to-progression after front-line fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy for chronic lymphocytic leukaemia: a retrospective, multicohort study

Author

Herling, Carmen D, Coombes, Kevin R, Benner, Axel, Bloehdorn, Johannes, Barron, Lynn L, Abrams, Zachary B, Majewski, Tadeusz, Bondaruk, Jolanta E, Bahlo, Jasmin, Fischer, Kirsten, Hallek, Michael, Stilgenbauer, Stephan, Czerniak, Bogdan A, Oakes, Christopher C, Ferrajoli, Alessandra, Keating, Michael J, and Abruzzo, Lynne V

Published
2019
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42. Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD

Author

Schlenk, Richard F., Weber, Daniela, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Salwender, Hans, Schroeder, Thomas, Kindler, Thomas, Lübbert, Michael, Wolf, Dominik, Westermann, Jörg, Kraemer, Doris, Götze, Katharina S., Horst, Heinz-August, Krauter, Jürgen, Girschikofsky, Michael, Ringhoffer, Mark, Südhoff, Thomas, Held, Gerhard, Derigs, Hans-Günter, Schroers, Roland, Greil, Richard, Grießhammer, Martin, Lange, Elisabeth, Burchardt, Alexander, Martens, Uwe, Hertenstein, Bernd, Marretta, Lore, Heuser, Michael, Thol, Felicitas, Gaidzik, Verena I., Herr, Wolfgang, Krzykalla, Julia, Benner, Axel, Döhner, Konstanze, Ganser, Arnold, Paschka, Peter, and Döhner, Hartmut

Published
2019
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43. Isatuximab, Carfilzomib, Lenalidomide, and Dexamethasone for the Treatment of High-Risk Newly Diagnosed Multiple Myeloma

Author

Leypoldt, Lisa B., primary, Tichy, Diana, additional, Besemer, Britta, additional, Hänel, Mathias, additional, Raab, Marc S., additional, Mann, Christoph, additional, Munder, Markus, additional, Reinhardt, Hans Christian, additional, Nogai, Axel, additional, Görner, Martin, additional, Ko, Yon-Dschun, additional, de Wit, Maike, additional, Salwender, Hans, additional, Scheid, Christof, additional, Graeven, Ullrich, additional, Peceny, Rudolf, additional, Staib, Peter, additional, Dieing, Annette, additional, Einsele, Hermann, additional, Jauch, Anna, additional, Hundemer, Michael, additional, Zago, Manola, additional, Požek, Ema, additional, Benner, Axel, additional, Bokemeyer, Carsten, additional, Goldschmidt, Hartmut, additional, and Weisel, Katja C., additional

Published
2023
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46. OA-43 Analysis of sustained MRD-negativity and progression-free survival of Isa-KRd in high-risk newly diagnosed multiple myeloma – additional data from planned interim analysis of the GMMG-CONCEPT trial

Author

Leypoldt, Lisa, primary, Tichy, Diana, additional, Besemer, Britta, additional, Hänel, Mathias, additional, Raab, Marc, additional, Mann, Christoph, additional, Munder, Markus, additional, Reinhardt, Hans Christian, additional, Nogai, Axel, additional, Görner, Martin, additional, Ko, Yon-Dschun, additional, de Wit, Maike, additional, Salwender, Hans, additional, Scheid, Christof, additional, Graeven, Ullrich, additional, Peceny, Rudolf, additional, Staib, Peter, additional, Dieing, Annette, additional, Einsele, Hermann, additional, Jauch, Anna, additional, Zago, Manola, additional, Benner, Axel, additional, Bokemeyer, Carsten, additional, Goldschmidt, Hartmut, additional, and Weisel, Katja, additional

Published
2023
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47. Genome‐wide study of genetic polymorphisms predictive for outcome from first‐line oxaliplatin‐based chemotherapy in colorectal cancer patients

Author

Park, Hanla A., primary, Edelmann, Dominic, additional, Canzian, Federico, additional, Seibold, Petra, additional, Harrison, Tabitha A., additional, Hua, Xinwei, additional, Shi, Qian, additional, Silverman, Allison, additional, Benner, Axel, additional, Macauda, Angelica, additional, Schneider, Martin, additional, Goldberg, Richard M., additional, Alberts, Steven R., additional, Hoffmeister, Michael, additional, Brenner, Hermann, additional, Chan, Andrew T., additional, Peters, Ulrike, additional, Newcomb, Polly A., additional, and Chang‐Claude, Jenny, additional

Published
2023
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48. P417: GENOMIC LANDSCAPE AND PROGNOSIS IN OLDER ACUTE MYELOID LEUKEMIA PATIENTS NOT ELIGIBLE FOR INTENSIVE CHEMOTHERAPY

Author

Jahn, Ekaterina, primary, Saadati, Maral, additional, Fenaux, Pierre, additional, Gobbi, Marco, additional, Roboz, Gail, additional, Bullinger, Lars, additional, Lutsik, Pavlo, additional, Riedel, Anna, additional, Plass, Christoph, additional, Jahn, Nikolaus, additional, Walter, Claudia, additional, Holzmann, Karlheinz, additional, Hao, Yong, additional, Naim, Sue, additional, Schreck, Nicholas, additional, Krzykalla, Julia, additional, Benner, Axel, additional, Keer, Harold, additional, Azab, Mohammad, additional, Döhner, Konstanze, additional, and Döhner, Hartmut, additional

Published
2023
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49. Fludarabine, cytarabine, and idarubicin with or without venetoclax in patients with relapsed/refractory acute myeloid leukemia

Author

Shahswar, Rabia, primary, Beutel, Gernot, additional, Gabdoulline, Razif, additional, Schwarzer, Adrian, additional, Kloos, Arnold, additional, Koenecke, Christian, additional, Stadler, Michael, additional, Gohring, Gudrun, additional, Behrens, Yvonne Lisa, additional, Li, Zhixiong, additional, Dallmann, Louisa-Kristin, additional, Klement, Piroska, additional, Albert, Catherin, additional, Wichmann, Martin, additional, Alwie, Yasmine, additional, Benner, Axel, additional, Saadati, Maral, additional, Ganser, Arnold, additional, Thol, Felicitas, additional, and Heuser, Michael, additional

Published
2023
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