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Sunscreens are an important tool used to protect the skin against harmful effects of ultraviolet (UV) radiation. Many different formulations of sunscreen exist today, which can be confusing to the consumer. In this article, we highlight and address many sunscreen myths that exist today including the benefits of higher SPF sunscreen, use of sunscreen in darker skin types, and the effects of sunscreen on vitamin D production. [ABSTRACT FROM AUTHOR]

This article from the Oxford Medical Case Reports discusses a case of yellow urticaria, a rare variant of urticaria, in a 79-year-old man with chronic lymphocytic leukemia (CLL) who had recently switched from ibrutinib to acalabrutinib. The patient presented with symptoms such as fatigue, malaise, abdominal pain, nausea, vomiting, diarrhea, and a new rash. Dermatology consultation and a shave biopsy confirmed the diagnosis of yellow urticaria, which was believed to be caused by acalabrutinib-induced liver injury. Treatment involved discontinuing acalabrutinib and administering cetirizine and diphenhydramine. The rash resolved and liver function normalized after one month of follow-up. The article emphasizes that yellow urticaria is a clinical diagnosis and treatment is symptomatic. It also notes that severe elevation of liver enzymes due to acalabrutinib is rare. The patient continues to be monitored for CLL but has deferred resuming treatment. [Extracted from the article]

Background: Dermatofibroma (DF) is a common benign skin neoplasm. Induction above DF lesions, including follicular unit induction, is a frequently observed phenomenon. Wnt signaling is known to be critical in hair follicle morphogenesis. Our study assesses the role of Wnt signaling in DF induction by evaluating intracellular localization of β‐catenin in various types of DF induction. Methods: Archived tissue collected between 1 October 1980 and 1 October 2013 was stained per protocol using hematoxylin and eosin and anti‐β‐catenin monoclonal antibody. Specimens were grouped into categories based on the presence or absence and type of induction. All specimens were scored for nuclear β‐catenin localization. Results: Of 62 specimens, 42 (68%) showed induction while 20 (32%) showed none. Nuclear β‐catenin staining was detected in 23 (55%) of the induction and in none of the no‐induction specimens (P‐value < 0.001). Types of induction included: 15 (24%) follicular induction, 31 (50%) acanthosis, and 4 (6%) sebaceous induction. For follicular induction, 13 (87%) showed positive nuclear β‐catenin staining compared to 11 (35%) for acanthosis and 1 (25%) for sebaceous induction (P‐value = 0.002). Conclusion: Our findings support the hypothesis that DFs promote an ectopic activation of Wnt pathway signaling in follicular induction phenomenon. [ABSTRACT FROM AUTHOR]