1. EVALUATION OF SURGICAL FACTORS AFFECTING VITREOUS HEMORRHAGE FOLLOWING PORT DELIVERY SYSTEM WITH RANIBIZUMAB IMPLANT INSERTION IN A MINIPIG MODEL
- Author
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Bantseev, Vladimir, Schuetz, Chris, Booler, Helen S, Horvath, Joshua, Hovaten, Kristof, Erickson, Signe, Bentley, Ellison, Nork, T Michael, Freeman, William R, Stewart, Jay M, and Barteselli, Giulio
- Subjects
Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Angiogenesis Inhibitors ,Animals ,Disease Models ,Animal ,Drug Delivery Systems ,Drug Implants ,Follow-Up Studies ,Homeostasis ,Intraocular Pressure ,Male ,Ranibizumab ,Sclera ,Swine ,Swine ,Miniature ,Vascular Endothelial Growth Factor A ,Visual Acuity ,Vitreous Body ,Vitreous Hemorrhage ,vitreous hemorrhage ,animal surgical model ,Port Delivery System ,anti-vascular endothelial growth factor ,retinal disease ,Opthalmology and Optometry ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
PurposeTo develop an animal model of vitreous hemorrhage (VH) to explore the impact of surgical parameters on VH associated with insertion of the Port Delivery System with ranibizumab (PDS) implant.MethodsNinety eyes from 45 treatment-naive male Yucatan minipigs received PDS implant insertion or a sham procedure. The effect of prophylactic pars plana hemostasis, scleral incision length, scleral cauterization, surgical blade type/size, and viscoelastic usage on postsurgical VH was investigated.ResultsPostsurgical VH was detected in 60.0% (54/90) of implanted eyes. A systematic effect on VH was only detected for pars plana hemostasis before the pars plana incision. The percentage of eyes with VH was 96.6% (28/29) among eyes that did not receive prophylactic pars plana hemostasis and 42.4% (24/58) among eyes that did. There was no VH in eyes that received laser ablation of the pars plana using overlapping 1,000-ms spots; pars plana cautery or diathermy was less effective. The majority of all VH cases (83.3% [45/54]) were of mild to moderate severity (involving ≤25% of the fundus).ConclusionIn this minipig surgical model of VH, scleral dissection followed by pars plana laser ablation before pars plana incision most effectively mitigated VH secondary to PDS implant insertion.
- Published
- 2020