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24,860 results on '"Benvenuti, A."'

1. Star-triangle dualities and supersymmetric improved bifundamentals

Author

Benvenuti, Sergio, Comi, Riccardo, and Pasquetti, Sara

Subjects
High Energy Physics - Theory
Abstract

Recently it was shown that mirror duals of 3d and 4d theories with four super-charges can be described by generalized quiver theories, constructed using strongly coupled SCFTs as elementary building blocks that replace and improve standard bifundamentals. In this work we study and extend the family of such improved bifundamentals and discuss the network of star-triangle dualities they satisfy. We provide a field theoretic proof of the star-triangle dualities, which only assumes the basic Seiberg dualities, using the sequential deconfinement technique., Comment: 69+15 pages with many figures

Published
2024

2. Guaranteed Feasibility in Differentially Private Linearly Constrained Convex Optimization

Author

Benvenuti, Alexander, Bialy, Brendan, Dennis, Miriam, and Hale, Matthew

Subjects
Mathematics - Optimization and Control
Abstract

Convex programming with linear constraints plays an important role in the operation of a number of everyday systems. However, absent any additional protections, revealing or acting on the solutions to such problems may reveal information about their constraints, which can be sensitive. Therefore, in this paper, we introduce a method for solving convex programs while keeping linear constraints private. First, we prove that this method is differentially private and always generates a feasible optimization problem (i.e., one whose solution exists). Then we show that the solution to the privatized problem also satisfies the original, non-private constraints. Next, we bound the expected loss in performance from privacy, which is measured by comparing the cost with privacy to that without privacy. Simulation results apply this framework to constrained policy synthesis in a Markov decision process, and they show that a typical privacy implementation induces only an approximately $9\%$ loss in solution quality., Comment: 2 figures, 6 pages

Published
2024

3. Deconfinements, Kutasov-Schwimmer dualities and $D_p[SU(N)]$ theories

Author

Benvenuti, Sergio, Comi, Riccardo, Pasquetti, Sara, and Sacchi, Matteo

Subjects
High Energy Physics - Theory
Abstract

Kutasov-Schwimmer (KS) dualities involve a rank-$2$ field with a polynomial superpotential. We derive KS-like dualities via deconfinement, that is assuming only Seiberg-like dualities, which instead just involve fundamental matter. Our derivation is split into two main steps. The first step is the construction of two families of linear quivers with $p\!-\!1$ nodes that confine into a rank-$2$ chiral field with degree-$(p\!+\!1)$ superpotential. Such chiral field is an $U(N)$ adjoint in 3d and an $USp(2N)$ antisymmetric in 4d. In the second step we use these linear quivers to derive, via deconfinement, in a relatively straightforward fashion, two classes of KS-like dualities: the Kim-Park duality for $U(N)$ with adjoint in 3d and the Intriligator duality for $USp(2N)$ with antisymmetric in 4d. We also discuss the close relation of our 3d family of confining unitary quivers to the 4d $\mathcal{N}\!=\!2$ $D_p[SU(N)]$ SCFTs by circle compactification and various deformations., Comment: 55+4 pages with many figures

Published
2024

4. Teens Online: How Perceived Social Support Influences the Use of the Internet during Adolescence

Author

Martina Benvenuti, Sabrina Panesi, Sara Giovagnoli, Patrizia Selleri, and Elvis Mazzoni

Abstract

This study analyses the role of social support in Internet use, focusing on when it leads to problematic or functional use in male and female adolescents. Three research hypotheses state: (1) when offline social support is low, online social support leads to a problematic Internet use; (2) when offline social support is high, online social support leads to a functional Internet use; (3) significant differences between male and female adolescents in both the online and offline dimensions considered. Results showed that the positive social interaction factor of online social support positively predicts problematic Internet use and that the latter is negatively affected by offline social support (affectionate dimension). Furthermore, online social support predicts functional Internet use (positive social interaction factor), while offline social support has no such effect. Finally, gender differences occur: males show higher problematic Internet use, and a higher number of friends and acquaintances than females, while females show higher online and offline social support than males. Implications of this research are particularly relevant for schools (e.g., teachers), families (parents, caregivers, etc.), and policy maker, so that they can support adolescents in the construction and development of offline friendly relationships and promote a functional use of the Internet for preventing its negative effects with active educational policies.

Published
2024
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5. Summary of SatHub, and the current observational status of satellite constellations

Author

Peel, Mike W., Eggl, Siegfried, Rawls, Meredith, Dadighat, Michelle, Benvenuti, Piero, di Vruno, Federico, and Walker, Connie

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Physics and Society, Physics - Space Physics
Abstract

SatHub is one of the four hubs of the IAU Centre for the Protection of the Dark and Quiet Sky from Satellite Constellation Interference (CPS). It focuses on observations, data analysis, software, and training materials to improve our understanding of the impact of satellite constellations on astronomy and observers worldwide. As a preface to more in-depth IAUS385 sessions, we gave a summary of some recent work by SatHub members and the current status of satellite constellations, including optical and radio observations. We shared how the audience can join or get more involved, e.g., via the CPS Slack for asynchronous collaboration. We also touched on what a future with hundreds of thousands of constellation satellites might look like., Comment: 8 pages, 5 figures, accepted for publication in "Astronomy and Satellite Constellations: Pathways Forward", proceedings of IAU Symposium 385

Published
2024

8. Mirror dualities with four supercharges

Author

Benvenuti, Sergio, Comi, Riccardo, and Pasquetti, Sara

Subjects
High Energy Physics - Theory
Abstract

We consider 3d N=2 non-abelian Hanany-Witten brane setups with chiral flavor symmetry. We propose that the associated field theories are quivers with improved bifundamentals, instead of standard bifundamentals. The improved bifundamental is a strongly coupled SCFT that carries one more U(1) global symmetry than the standard bifundamental. As a consequence, our proposal overcomes the long standing challenge of associating to each N=2 brane setup a gauge theory with the full rank global symmetry, allowing the study of all the usual supersymmetric observables, such as superconformal index, sphere partition function, chiral ring and moduli space. The construction passes many non-trivial tests, for instance we algorithmically prove that any two improved quivers associated to S-dual brane setups are infrared dual. The 3d N=2 mirror dualities can be uplifted to 4d dualities with 4d improved bifundamentals connecting USp(2N) nodes., Comment: 76+41 pages. V2 includes the discussion of SQCD without adjoint

Published
2023

9. Improved Performance of Organic Light-Emitting Transistors Enabled by Polyurethane Gate Dielectric

Author

Barreto, Arthur R. J., Candiotto, Graziâni, Avila, Harold J. C., Carvalho, Rafael S., Santos, Aline Magalhães dos, Prosa, Mario, Benvenuti, Emilia, Moschetto, Salvatore, Toffanin, Stefano, Capaz, Rodrigo B., Muccini, Michele, and Cremona, Marco

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Applied Physics, Physics - Chemical Physics
Abstract

Organic light-emitting transistors (OLETs) are multifunctional optoelectronic devices that combine in a single structure the advantages of organic light emitting diodes (OLEDs) and organic field-effect transistors (OFETs). However, low charge mobility and high threshold voltage are critical hurdles to practical OLETs implementation. This work reports on the improvements obtained by using polyurethane films as dielectric layer material in place of the standard poly(methylmethacrylate) (PMMA) in OLET devices. It was found that polyurethane drastically reduces the number of traps in the device thereby improving electrical and optoelectronic device parameters. In addition, a model was developed to rationalize an anomalous behavior at the pinch-off voltage. Our findings represent a step forward to overcome the limiting factors of OLETs that prevent their use in commercial electronics by providing a simple route for low-bias device operation., Comment: 25 pages, 5 figures, 1 table

Published
2023
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13. Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes

Author

Alraies, Zahraa, Rivera, Claudia A., Delgado, Maria-Graciela, Sanséau, Doriane, Maurin, Mathieu, Amadio, Roberto, Maria Piperno, Giulia, Dunsmore, Garett, Yatim, Aline, Lacerda Mariano, Livia, Kniazeva, Anna, Calmettes, Vincent, Sáez, Pablo J., Williart, Alice, Popard, Henri, Gratia, Matthieu, Lamiable, Olivier, Moreau, Aurélie, Fusilier, Zoé, Crestey, Lou, Albaud, Benoit, Legoix, Patricia, Dejean, Anne S., Le Dorze, Anne-Louise, Nakano, Hideki, Cook, Donald N., Lawrence, Toby, Manel, Nicolas, Benvenuti, Federica, Ginhoux, Florent, Moreau, Hélène D., P. F. Nader, Guilherme, Piel, Matthieu, and Lennon-Duménil, Ana-Maria

Published
2024
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17. Differentially Private Computation of Basic Reproduction Numbers in Networked Epidemic Models

Author

Chen, Bo, She, Baike, Hawkins, Calvin, Benvenuti, Alex, Fallin, Brandon, Paré, Philip E., and Hale, Matthew

Subjects
Computer Science - Social and Information Networks, Computer Science - Cryptography and Security, Physics - Physics and Society
Abstract

The basic reproduction number of a networked epidemic model, denoted $R_0$, can be computed from a network's topology to quantify epidemic spread. However, disclosure of $R_0$ risks revealing sensitive information about the underlying network, such as an individual's relationships within a social network. Therefore, we propose a framework to compute and release $R_0$ in a differentially private way. First, we provide a new result that shows how $R_0$ can be used to bound the level of penetration of an epidemic within a single community as a motivation for the need of privacy, which may also be of independent interest. We next develop a privacy mechanism to formally safeguard the edge weights in the underlying network when computing $R_0$. Then we formalize tradeoffs between the level of privacy and the accuracy of values of the privatized $R_0$. To show the utility of the private $R_0$ in practice, we use it to bound this level of penetration under privacy, and concentration bounds on these analyses show they remain accurate with privacy implemented. We apply our results to real travel data gathered during the spread of COVID-19, and we show that, under real-world conditions, we can compute $R_0$ in a differentially private way while incurring errors as low as $7.6\%$ on average., Comment: 8 pages, 3 figures

Published
2023

18. Differentially Private Reward Functions in Policy Synthesis for Markov Decision Processes

Author

Benvenuti, Alexander, Hawkins, Calvin, Fallin, Brandon, Chen, Bo, Bialy, Brendan, Dennis, Miriam, and Hale, Matthew

Subjects
Electrical Engineering and Systems Science - Systems and Control
Abstract

Markov decision processes often seek to maximize a reward function, but onlookers may infer reward functions by observing the states and actions of such systems, revealing sensitive information. Therefore, in this paper we introduce and compare two methods for privatizing reward functions in policy synthesis for multi-agent Markov decision processes, which generalize Markov decision processes. Reward functions are privatized using differential privacy, a statistical framework for protecting sensitive data. The methods we develop perturb either (1) each agent's individual reward function or (2) the joint reward function shared by all agents. We show that approach (1) provides better performance. We then develop a polynomial-time algorithm for the numerical computation of the performance loss due to privacy on a case-by-case basis. Next, using approach (1), we develop guidelines for selecting reward function values to preserve ``goal" and ``avoid" states while still remaining private, and we quantify the increase in computational complexity needed to compute policies from privatized rewards. Numerical simulations are performed on three classes of systems and they reveal a surprising compatibility with privacy: using reasonably strong privacy ($\epsilon =1.3$) on average induces as little as a~$5\%$ decrease in total accumulated reward and a $0.016\%$ increase in computation time., Comment: 16 Pages, 11 figures

Published
2023

20. Measurement of the background in the CMS muon detector in pps=13TeV-collisions at pps=13TeV pps=13TeV

Author

Tytgat, M., Muhammad, A., De Lentdecker, G., Jaramillo, J., Moureaux, L., Pétré, L., Yang, Y., Rendón, C., Gokbulut, G., Hong, Y., Samalan, A., Alves, G. A., Marujo da Silva, F., Alves Coelho, E., Barroso Ferreira Filho, M., Da Costa, E. M., De Jesus Damiao, D., Ferreira, B. C., Fonseca De Souza, S., Mota Amarilo, K., Nogima, H., Santoro, A., Thiel, M., Aleksandrov, A., Dimitrov, L., Hadjiiska, R., Iaydjiev, P., Misheva, M., Mitev, G., Ratchev, L., Rashevski, G., Shopova, M., Sultanov, G., Dimitrov, A., Litov, L., Pavlov, B., Petkov, P., Petrov, A., Shumka, E., Keshri, S., Thakur, S., Chen, M., Dong, X., Gong, W., Hou, Q., Jiang, C., Kou, H., Liu, Z.-A., Luo, W., Song, J., Sun, L., Wang, N., Wang, Y., Wang, Z., Zhang, C., Zhang, Y., Zhang, H., Zhao, J., Agapitos, A., Ban, Y., Levin, A., Li, Q., Qian, S. J., Wang, D., Wang, K., You, Z., Avila, C., Barbosa Trujillo, D. A., Cabrera, A., Florez, C. A., Fraga, J., Reyes Vega, J. A., Ramirez, F., Rodriguez, M., Ruiz, J. D., Vanegas, N., Abdalla, H., Abdelalim, A. A., Assran, Y., Radi, A., Crotty, I., Mahmoud, M. A., Balleyguier, L., Chen, X., Combaret, C., Galbit, G., Gouzevitch, M., Grenier, G., Laktineh, I. B., Luciol, A., Mirabito, L., Tromeur, W., Bagaturia, I., Lomidze, I., Kemularia, O., Tsamalaidze, Z., Böttger, U., Eliseev, D., Hebbeker, T., Hoepfner, K., Merschmeyer, M., Ivone, F., Mukherjee, S., Nowotny, F., Philipps, B., Reithler, H., Sharma, A., Torres Da Silva De Araujo, F., Wiedenbeck, S., Zaleski, S., Zantis, F. P., Abbas, M., Mallows, S., Bencze, G., Beni, N., Molnar, J., Szillasi, Z., Teyssier, D., Ujvari, B., Zilizi, G., Babbar, J., Bansal, S., Bhatnagar, V., Chauhan, S., Kaur, A., Kaur, H., Kaur Sahota, A., Kumar, S., Sheokand, T., Singh, J., Choudhary, B. C., Kumar, A., Kumar Saini, M., Naimuddin, M., Majumdar, N., Mukhopadhyay, S., Rout, P., Amoozegar, V., Boghrati, B., Ebraimi, M., Mohammadi Najafabadi, M., Zareian, E., Abbrescia, M., Aly, R., Buonsante, M., Colaleo, A., De Filippis, N., Dell’Olio, D., De Robertis, G., Elmetenawee, W., Ferrara, N., Franco, M., Iaselli, G., Lacalamita, N., Licciulli, F., Loddo, F., Maggi, M., Martiradonna, S., Nuzzo, S., Longo, L., Pellecchia, A., Pugliese, G., Radogna, R., Ramos, D., Ranieri, A., Simone, F. M., Stamerra, A., Troiano, D., Venditti, R., Verwilligen, P., Zaza, A., Abbiendi, G., Baldanza, C., Battilana, C., Benvenuti, A., Borgonovi, L., Cafaro, V., Cavallo, F. R., Crupano, A., Cuffiani, M., Dallavalle, G. M., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Giordano, V., Guandalini, C., Guiducci, L., Lo Meo, S., Lunerti, L., Marcellini, S., Masetti, G., Navarria, F. L., Paggi, G., Perrotta, A., Primavera, F., Rossi, A. M., Rovelli, T., Torromeo, G., Benussi, L., Bianco, S., Campagnola, R., Caponero, M., Colafranceschi, S., Meola, S., Passamonti, L., Piccolo, D., Pierluigi, D., Raffone, G., Russo, A., Saviano, G., Buontempo, S., Cagnotta, A., Carnevali, F., Cassese, F., Cavallo, N., De Iorio, A., Fabozzi, F., Iorio, A. O. M., Lista, L., Paolucci, P., Passeggio, G., Rossi, B., Barcellan, L., Bellato, M., Benettoni, M., Bergnoli, A., Bragagnolo, A., Carlin, R., Castellani, L., Checchia, P., Ciano, L., Colombo, A., Corti, D., Gasparini, F., Gasparini, U., Gonella, F., Gozzelino, A., Griggio, A., Grosso, G., Gulmini, M., Isocrate, R., Lusiani, E., Maron, G., Margoni, M., Meneguzzo, A. T., Migliorini, M., Modenese, L., Montecassiano, F., Negrello, M., Passaseo, M., Pazzini, J., Ramina, L., Rampazzo, M., Rebeschini, M., Ronchese, P., Rossin, R., Simonetto, F., Toffano, M., Toniolo, N., Triossi, A., Ventura, S., Zanetti, M., Zatti, P. G., Zotto, P., Zucchetta, A., AbuZeid, S., Aimè, C., Braghieri, A., Calzaferri, S., Fiorina, D., Gigli, S., Montagna, P., Riccardi, C., Salvini, P., Vai, I., Vitulo, P., Amapane, N., Cotto, G., Dattola, D., De Remigis, P., Kiani, B., Mariotti, C., Maselli, S., Pelliccioni , M., Rotondo, F., Staiano, A., Trocino, D., Umoret, G., Asilar, E., Kim, T. J., Merlin, J. A., Choi, S., Hong, B., Lee, K. S., Goh, J., Choi, J., Kim, J., Yang, U., Yoon, I., Jang, W., Heo, J., Kang, D., Kang, Y., Kim, D., Kim, S., Ko, B., Lee, J. S. H., Park, I. C., Watson, I. J., Yang, S., Jeong, Y., Lee, Y., Yu, I., Alasfour, G., Beyrouthy, T., Gharbia, Y., Maghrbi, Y., Otkur, M., Castilla-Valdez, H., Crotte Ledesma, H., Lopez-Fernandez, R., Sánchez Hernández, A., Ramírez García, M., Vazquez, E., Shah, M. A., Zaganidis, N., Pedraza, I., Uribe Estrada, C., Ahmad, A., Ahmed, W., Asghar, M. I., Hoorani, H. R., Muhammad, S., Wajid, A., Alcaraz Maestre, J., Álvarez Fernández, A., Fernandez Bedoya, Cristina F., Blanco Ramos, L. C., Calvo, E., Carrillo Montoya, C. A., Cela Ruiz, J. M., Cepeda, M., Cerrada, M., Colino, N., Cuadrado Calzada, S., Cuchillo Ortega, J., De La Cruz, B., de Lara Rodríguez, C. I., Fernández Del Val, D., Fernández Ramos, J. P., Fouz, M. C., Francia Ferrero, D., García Romero, J., Gonzalez Lopez, O., Goy Lopez, S., Josa, M. I., León Holgado, J., Manzanilla Carretero, O., Martín Martín, I., Martínez Morales, J. J., Martín Viscasillas, E., Moran, D., Navarro Tobar, Á., Paz Herrera, R., Puras Sánchez, J. C., Puerta Pelayo, J., Pulido Ferrero, S., Redondo, I., Redondo Ferrero, D. D., Salto Parra, V., Sánchez Navas, S., Sastre, J., Urda Gómez, L., Vazquez Escobar, J., de Trocóniz, J. F., Frias Garcia-Lago, F., Reyes-Almanza, R., Alvarez Gonzalez, B., Cuevas, J., Fernandez Menendez, J., Folgueras, S., Gonzalez Caballero, I., Leguina López, P., Palencia Cortezon, E., Ramón Álvarez, C., Prado Pico, J., Rodríguez Bouza, V., Soto Rodríguez, A., Trapote, A., Villalba, C. Vico, Kailasapathy, B., Malagalage, K., Sonnadara, D. U. J., Wickramarathna, D. D. C., Dharmaratna, W. G. D., Liyanage, K., Perera, N., Wickramage, N., Aspell, P., Bianco, M., Bozzato, D., Brachet, S., Conde Garcia, A., Dabrowski, A., De Oliveira, R., Fallavollita, F., Kicsiny, P., Sharma, A., Hazen, E., May, S., Peck, A., Salyer, K., Suarez, I., Abbott, S., Bonilla, J., Breedon, R., Cai, H., Cox, P. T., Erbacher, R., Kukral, O., McLean, C., Mocellin, G., Mulhearn, M., Regnery, B., Tripathi, M., Waegel, G., Yao, Y., Carlson, J., Cousins, R., Dasgupta, A., Datta, A., Hauser, J., Ignatenko, M., Iqbal, M. A., Lo, C., Saltzberg, D., Schnaible, C., Valuev, V., Clare, R., Gordon, M., Hanson, G., Amin, N., Bradmiller-Feld, J., Campagnari, C., Danielson, T., Dishaw, A., Dorsett, A., Kim, J., Marsh, B., Mei, H., Oshiro, M., Richman, J., Setti, F., Sevilla, M. F., Siddireddy, P., Wang, S., Aruta, C., Barashko, V., Cherepanov, V., Dittrich, M., Korytov, A., Kuznetsova, E., Madorsky, A., Mitselmakher, G., Muthirakalayil Madhu, A., Rawal, N., Terentyev, N., Wang, J., Alsufyani, B., Butalla, S., Elkafrawy, T., Hohlmann, M., Yanes, E., Eysermans, J., Barberis, E., Haddad, Y., Han, Y., Madigan, G., Morse, D. M., Nguyen, V., Wood, D., Bhattacharya, S., Bueghly, J., Chen, Z., Hahn, K. A., Liu, Y., Miao, Y., Monk, D. G., Schmitt, M. H., Taliercio, A., Velasco, M., Bylsma, B., Carrigan, M., De Los Santos, R., Durkin, L. S., Hill, C., Banicz, K., Liu, J., Matveev, M., Padley, B. P., Aebi, D., Ahmad, M., Akhter, T., Bolshov, A., Bouhali, O., Eusebi, R., Gilmore, J., Huang, T., Juska, E., Kamon, T., Kim, H., Kizlov, M., Malhotra, S., Mueller, R., Rabadan, R., Rathjens, D., Safonov, A., Karchin, P. E., Aravind, A., Black, K., De Bruyn, I., Everaerts, P., Galloni, C., Herndon, M., Lanaro, A., Loveless, R., Madhusudanan Sreekala, J., Mondal, S., Teague, D., Vetens, W., Warden, A., Azhgirey, I., Borshch, V., Chtchipunov, L., Egorov, A., Gavrilov, G., Golovtcov, V., Ivanov, M., Ivantchenko, V., Ivanov, Y., Karjavine, V., Khodinov, A., Kim, V., Kurochkin, I. A., Levchenko, P., Murzin, V., Nasybulin, S., Oreshkin, V., Palichik, V., Perelygin, V., Riabchikova, A., Sosnov, D., Sulimov, V., Uvarov, L., Vavilov, S., and Vorobyev, A.

Published
2024
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22. Mirror dualities with four supercharges

Author

Sergio Benvenuti, Riccardo Comi, and Sara Pasquetti

Subjects
Supersymmetry and Duality, Brane Dynamics in Gauge Theories, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We consider 3d N $$ \mathcal{N} $$ = 2 non-abelian Hanany-Witten brane setups with chiral flavor symmetry. We propose that the associated field theories are quivers with improved bifundamentals, instead of standard bifundamentals. The improved bifundamental is a strongly coupled SCFT that carries one more U(1) global symmetry than the standard bifundamental. As a consequence, our proposal overcomes the long standing challenge of associating to each N $$ \mathcal{N} $$ = 2 brane setup a gauge theory with the full rank global symmetry, allowing the study of all the usual supersymmetric observables, such as superconformal index, sphere partition function, chiral ring and moduli space. The construction passes many non-trivial tests, for instance we algorithmically prove that any two improved quivers associated to S $$ \mathcal{S} $$ -dual brane setups are infrared dual. The 3d N $$ \mathcal{N} $$ = 2 mirror dualities can be uplifted to 4d dualities with 4d improved bifundamentals connecting USp(2N) nodes.

Published
2024
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23. Measurement of the background in the CMS muon detector in $${p}{p}$$ pp -collisions at $$\sqrt{s} = 13$$ s = 13 $$\,\text {Te}\hspace{-.08em}\text {V}$$ Te V

Author

CMS Muon Group, M. Tytgat, A. Muhammad, G. De Lentdecker, J. Jaramillo, L. Moureaux, L. Pétré, Y. Yang, C. Rendón, G. Gokbulut, Y. Hong, A. Samalan, G. A. Alves, F. Marujo da Silva, E. Alves Coelho, M. Barroso Ferreira Filho, E. M. Da Costa, D. De Jesus Damiao, B. C. Ferreira, S. Fonseca De Souza, K. Mota Amarilo, H. Nogima, A. Santoro, M. Thiel, A. Aleksandrov, L. Dimitrov, R. Hadjiiska, P. Iaydjiev, M. Misheva, G. Mitev, L. Ratchev, G. Rashevski, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, M. Chen, X. Dong, W. Gong, Q. Hou, C. Jiang, H. Kou, Z.-A. Liu, W. Luo, J. Song, L. Sun, N. Wang, Y. Wang, Z. Wang, C. Zhang, Y. Zhang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, A. Levin, Q. Li, S. J. Qian, D. Wang, K. Wang, Z. You, C. Avila, D. A. Barbosa Trujillo, A. Cabrera, C. A. Florez, J. Fraga, J. A. Reyes Vega, F. Ramirez, M. Rodriguez, J. D. Ruiz, N. Vanegas, H. Abdalla, A. A. Abdelalim, Y. Assran, A. Radi, I. Crotty, M. A. Mahmoud, L. Balleyguier, X. Chen, C. Combaret, G. Galbit, M. Gouzevitch, G. Grenier, I. B. Laktineh, A. Luciol, L. Mirabito, W. Tromeur, I. Bagaturia, I. Lomidze, O. Kemularia, Z. Tsamalaidze, U. Böttger, D. Eliseev, T. Hebbeker, K. Hoepfner, M. Merschmeyer, F. Ivone, S. Mukherjee, F. Nowotny, B. Philipps, H. Reithler, A. Sharma, F. Torres Da Silva De Araujo, S. Wiedenbeck, S. Zaleski, F. P. Zantis, M. Abbas, S. Mallows, G. Bencze, N. Beni, J. Molnar, Z. Szillasi, D. Teyssier, B. Ujvari, G. Zilizi, J. Babbar, S. Bansal, V. Bhatnagar, S. Chauhan, A. Kaur, H. Kaur, A. Kaur Sahota, S. Kumar, T. Sheokand, J. Singh, B. C. Choudhary, A. Kumar, M. Kumar Saini, M. Naimuddin, N. Majumdar, S. Mukhopadhyay, P. Rout, V. Amoozegar, B. Boghrati, M. Ebraimi, M. Mohammadi Najafabadi, E. Zareian, M. Abbrescia, R. Aly, M. Buonsante, A. Colaleo, N. De Filippis, D. Dell’Olio, G. De Robertis, W. Elmetenawee, N. Ferrara, M. Franco, G. Iaselli, N. Lacalamita, F. Licciulli, F. Loddo, M. Maggi, S. Martiradonna, S. Nuzzo, L. Longo, A. Pellecchia, G. Pugliese, R. Radogna, D. Ramos, A. Ranieri, F. M. Simone, A. Stamerra, D. Troiano, R. Venditti, P. Verwilligen, A. Zaza, G. Abbiendi, C. Baldanza, C. Battilana, A. Benvenuti, L. Borgonovi, V. Cafaro, F. R. Cavallo, A. Crupano, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, V. Giordano, C. Guandalini, L. Guiducci, S. Lo Meo, L. Lunerti, S. Marcellini, G. Masetti, F. L. Navarria, G. Paggi, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. Torromeo, L. Benussi, S. Bianco, R. Campagnola, M. Caponero, S. Colafranceschi, S. Meola, L. Passamonti, D. Piccolo, D. Pierluigi, G. Raffone, A. Russo, G. Saviano, S. Buontempo, A. Cagnotta, F. Carnevali, F. Cassese, N. Cavallo, A. De Iorio, F. Fabozzi, A. O. M. Iorio, L. Lista, P. Paolucci, G. Passeggio, B. Rossi, L. Barcellan, M. Bellato, M. Benettoni, A. Bergnoli, A. Bragagnolo, R. Carlin, L. Castellani, P. Checchia, L. Ciano, A. Colombo, D. Corti, F. Gasparini, U. Gasparini, F. Gonella, A. Gozzelino, A. Griggio, G. Grosso, M. Gulmini, R. Isocrate, E. Lusiani, G. Maron, M. Margoni, A. T. Meneguzzo, M. Migliorini, L. Modenese, F. Montecassiano, M. Negrello, M. Passaseo, J. Pazzini, L. Ramina, M. Rampazzo, M. Rebeschini, P. Ronchese, R. Rossin, F. Simonetto, M. Toffano, N. Toniolo, A. Triossi, S. Ventura, M. Zanetti, P. G. Zatti, P. Zotto, A. Zucchetta, S. AbuZeid, C. Aimè, A. Braghieri, S. Calzaferri, D. Fiorina, S. Gigli, P. Montagna, C. Riccardi, P. Salvini, I. Vai, P. Vitulo, N. Amapane, G. Cotto, D. Dattola, P. De Remigis, B. Kiani, C. Mariotti, S. Maselli, M. Pelliccioni, F. Rotondo, A. Staiano, D. Trocino, G. Umoret, E. Asilar, T. J. Kim, J. A. Merlin, S. Choi, B. Hong, K. S. Lee, J. Goh, J. Choi, J. Kim, U. Yang, I. Yoon, W. Jang, J. Heo, D. Kang, Y. Kang, D. Kim, S. Kim, B. Ko, J. S. H. Lee, I. C. Park, I. J. Watson, S. Yang, Y. Jeong, Y. Lee, I. Yu, G. Alasfour, T. Beyrouthy, Y. Gharbia, Y. Maghrbi, M. Otkur, H. Castilla-Valdez, H. Crotte Ledesma, R. Lopez-Fernandez, A. Sánchez Hernández, M. Ramírez García, E. Vazquez, M. A. Shah, N. Zaganidis, I. Pedraza, C. Uribe Estrada, A. Ahmad, W. Ahmed, M. I. Asghar, H. R. Hoorani, S. Muhammad, A. Wajid, J. Alcaraz Maestre, A. Álvarez Fernández, Cristina F. Fernandez Bedoya, L. C. Blanco Ramos, E. Calvo, C. A. Carrillo Montoya, J. M. Cela Ruiz, M. Cepeda, M. Cerrada, N. Colino, S. Cuadrado Calzada, J. Cuchillo Ortega, B. De La Cruz, C. I. de Lara Rodríguez, D. Fernández Del Val, J. P. Fernández Ramos, M. C. Fouz, D. Francia Ferrero, J. García Romero, O. Gonzalez Lopez, S. Goy Lopez, M. I. Josa, J. León Holgado, O. Manzanilla Carretero, I. Martín Martín, J. J. Martínez Morales, E. Martín Viscasillas, D. Moran, Á. Navarro Tobar, R. Paz Herrera, J. C. Puras Sánchez, J. Puerta Pelayo, S. Pulido Ferrero, I. Redondo, D. D. Redondo Ferrero, V. Salto Parra, S. Sánchez Navas, J. Sastre, L. Urda Gómez, J. Vazquez Escobar, J. F. de Trocóniz, F. Frias Garcia-Lago, R. Reyes-Almanza, B. Alvarez Gonzalez, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, P. Leguina López, E. Palencia Cortezon, C. Ramón Álvarez, J. Prado Pico, V. Rodríguez Bouza, A. Soto Rodríguez, A. Trapote, C. Vico Villalba, B. Kailasapathy, K. Malagalage, D. U. J. Sonnadara, D. D. C. Wickramarathna, W. G. D. Dharmaratna, K. Liyanage, N. Perera, N. Wickramage, P. Aspell, M. Bianco, D. Bozzato, S. Brachet, A. Conde Garcia, A. Dabrowski, R. De Oliveira, F. Fallavollita, P. Kicsiny, E. Hazen, S. May, A. Peck, K. Salyer, I. Suarez, S. Abbott, J. Bonilla, R. Breedon, H. Cai, P. T. Cox, R. Erbacher, O. Kukral, C. McLean, G. Mocellin, M. Mulhearn, B. Regnery, M. Tripathi, G. Waegel, Y. Yao, J. Carlson, R. Cousins, A. Dasgupta, A. Datta, J. Hauser, M. Ignatenko, M. A. Iqbal, C. Lo, D. Saltzberg, C. Schnaible, V. Valuev, R. Clare, M. Gordon, G. Hanson, N. Amin, J. Bradmiller-Feld, C. Campagnari, T. Danielson, A. Dishaw, A. Dorsett, B. Marsh, H. Mei, M. Oshiro, J. Richman, F. Setti, M. F. Sevilla, P. Siddireddy, S. Wang, C. Aruta, V. Barashko, V. Cherepanov, M. Dittrich, A. Korytov, E. Kuznetsova, A. Madorsky, G. Mitselmakher, A. Muthirakalayil Madhu, N. Rawal, N. Terentyev, J. Wang, B. Alsufyani, S. Butalla, T. Elkafrawy, M. Hohlmann, E. Yanes, J. Eysermans, E. Barberis, Y. Haddad, Y. Han, G. Madigan, D. M. Morse, V. Nguyen, D. Wood, S. Bhattacharya, J. Bueghly, Z. Chen, K. A. Hahn, Y. Liu, Y. Miao, D. G. Monk, M. H. Schmitt, A. Taliercio, M. Velasco, B. Bylsma, M. Carrigan, R. De Los Santos, L. S. Durkin, C. Hill, K. Banicz, J. Liu, M. Matveev, B. P. Padley, D. Aebi, M. Ahmad, T. Akhter, A. Bolshov, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, E. Juska, T. Kamon, H. Kim, M. Kizlov, S. Malhotra, R. Mueller, R. Rabadan, D. Rathjens, A. Safonov, P. E. Karchin, A. Aravind, K. Black, I. De Bruyn, P. Everaerts, C. Galloni, M. Herndon, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, S. Mondal, D. Teague, W. Vetens, A. Warden, I. Azhgirey, V. Borshch, L. Chtchipunov, A. Egorov, G. Gavrilov, V. Golovtcov, M. Ivanov, V. Ivantchenko, Y. Ivanov, V. Karjavine, A. Khodinov, V. Kim, I. A. Kurochkin, P. Levchenko, V. Murzin, S. Nasybulin, V. Oreshkin, V. Palichik, V. Perelygin, A. Riabchikova, D. Sosnov, V. Sulimov, L. Uvarov, S. Vavilov, and A. Vorobyev

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The CMS detector, including its muon system, has been operating at the CERN LHC in increasingly challenging conditions for about 15 years. The muon detector was designed to provide excellent triggering and track reconstruction for muons produced in proton–proton collisons at an instantaneous luminosity ( $$\mathcal {L}$$ L ) of $$1 \times 10^{34}$$ 1 × 10 34 cm $$^{-2}$$ - 2 s $$^{-1}$$ - 1 . During the Run 2 data-taking period (2015–2018), the LHC achieved an instantaneous luminosity of twice its design value, resulting in larger background rates and making the efficient detection of muons more difficult. While some backgrounds result from natural radioactivity, cosmic rays, and interactions of the circulating protons with residual gas in the beam pipe, the dominant source of background hits in the muon system arises from proton–proton interactions themselves. Charged hadrons leaving the calorimeters produce energy deposits in the muon chambers. In addition, high-energy particles interacting in the hadron calorimeter and forward shielding elements generate thermal neutrons, which leak out of the calorimeter and shielding structures, filling the CMS cavern. We describe the method used to measure the background rates in the various muon subsystems. These rates, in conjunction with simulations, can be used to estimate the expected backgrounds in the High-Luminosity LHC. This machine will run for at least 10 years starting in 2029 reaching an instantaneous luminosity of $$\mathcal {L} = 5 \times \text {10}^\text {34}\,\text {cm}^\text {-2}\,\text {s}^\text {-1}$$ L = 5 × 10 34 cm -2 s -1 and increasing ultimately to $$\mathcal {L} = 7.5 \times \text {10}^\text {34}\,\text {cm}^\text {-2}\,\text {s}^\text {-1}$$ L = 7.5 × 10 34 cm -2 s -1 . These background estimates have been a key ingredient for the planning and design of the muon detector upgrade.

Published
2024
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27. Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors

Author

López, Lucía, Morosi, Luciano Gastón, La Terza, Federica, Bourdely, Pierre, Rospo, Giuseppe, Amadio, Roberto, Piperno, Giulia Maria, Russo, Valentina, Volponi, Camilla, Vodret, Simone, Joshi, Sonal, Giannese, Francesca, Lazarevic, Dejan, Germano, Giovanni, Stoitzner, Patrizia, Bardelli, Alberto, Dalod, Marc, Pace, Luigia, Caronni, Nicoletta, Guermonprez, Pierre, and Benvenuti, Federica

Published
2024
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28. EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening

Author

Cappelletto, Ambra, Alfì, Edoardo, Volf, Nina, Vu, Thi Van Anh, Bortolotti, Francesca, Ciucci, Giulio, Vodret, Simone, Fantuz, Marco, Perin, Martina, Colliva, Andrea, Rozzi, Giacomo, Rossi, Matilde, Ruozi, Giulia, Zentilin, Lorena, Vuerich, Roman, Borin, Daniele, Lapasin, Romano, Piazza, Silvano, Chiesa, Mattia, Lorizio, Daniela, Triboli, Luca, Kumar, Sandeep, Morello, Gaia, Tripodo, Claudio, Pinamonti, Maurizio, Piperno, Giulia Maria, Benvenuti, Federica, Rustighi, Alessandra, Jo, Hanjoong, Piccolo, Stefano, Del Sal, Giannino, Carrer, Alessandro, Giacca, Mauro, and Zacchigna, Serena

Published
2024
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31. Characterization of two transcriptomic subtypes of marker-null large cell carcinoma of the lung suggests different origin and potential new therapeutic perspectives

Author

Simbolo, Michele, Centonze, Giovanni, Gkountakos, Anastasios, Monti, Valentina, Maisonneuve, Patrick, Golovco, Stela, Sabella, Giovanna, Del Gobbo, Alessandro, Gobbo, Stefano, Ferrero, Stefano, Fabbri, Alessandra, Pardo, Carlotta, Garzone, Giovanna, Prinzi, Natalie, Pusceddu, Sara, Testi, Adele, Rolli, Luigi, Mangogna, Alessandro, Bercich, Luisa, Benvenuti, Mauro Roberto, Bria, Emilio, Pilotto, Sara, Berruti, Alfredo, Pastorino, Ugo, Capella, Carlo, Infante, Maurizio, Milella, Michele, Scarpa, Aldo, and Milione, Massimo

Published
2024
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33. Non-invertible symmetries along 4d RG flows

Author

Damia, Jeremias Aguilera, Argurio, Riccardo, Benini, Francesco, Benvenuti, Sergio, Copetti, Christian, and Tizzano, Luigi

Subjects
High Energy Physics - Theory
Abstract

We explore novel examples of RG flows preserving a non-invertible self-duality symmetry. Our main focus is on $\mathcal{N}=1$ quadratic superpotential deformations of 4d $\mathcal{N}=4$ super-Yang-Mills theory with gauge algebra $\mathfrak{su}(N)$. A theory that can be obtained in this way is the so-called $\mathcal{N}=1^*$ SYM where all adjoint chiral multiplets have a mass. Such IR theory exhibits a rich structure of vacua which we thoroughly examine. Our analysis elucidates the physics of spontaneous breaking of self-duality symmetry occurring in the degenerate gapped vacua. The construction can be generalized, taking as UV starting point a theory of class $\mathcal{S}$, to demonstrate how non-invertible self-duality symmetries exist in a variety of $\mathcal{N}=1$ SCFTs. We finally apply this understanding to prove that the conifold theory has a non-invertible self-duality symmetry., Comment: 48 pages + appendices. v2: refs added and typos corrected

Published
2023
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34. S-confining gauge theories and supersymmetry enhancements

Author

Bajeot, Stephane, Benvenuti, Sergio, and Sacchi, Matteo

Subjects
High Energy Physics - Theory
Abstract

We propose new classes of $4d$ $\mathcal{N}\!=\!1$ S-confining gauge theories, with a simple gauge group, rank-two matter and cubic superpotentials. The gauge group can be symplectic, orthogonal or special unitary. In some cases we derive the dualities via the deconfinement technique that uses iteratively known, more fundamental, dualities. In the symplectic case we discuss the $3d$ reduction to a confining unitary gauge theory with monopole superpotential. This $3d$ S-confinement provides an understanding of a recently proposed $4d$ $\mathcal{N}\!=\!1$ theory that flows to the conformal manifold of $\mathcal{N}\!=\!4$ SYM with $SU(2n+1)$ gauge group. The $3d$ perspective allows us to generalize this construction to another similar flow with supersymmetry enhancement: a $4d$ $\mathcal{N}\!=\!1$ theory that flows to the conformal manifold of a $4d$ $\mathcal{N}\!=\!2$ necklace theory with $SU(2n+1)^3$ gauge group., Comment: 38 pages + appendices

Published
2023

35. Isogeometric multi-patch $C^1$-mortar coupling for the biharmonic equation

Author

Benvenuti, Andrea, Loli, Gabriele, Sangalli, Giancarlo, and Takacs, Thomas

Subjects
Mathematics - Numerical Analysis
Abstract

We propose an isogeometric mortar method to fourth order elliptic problems. In particular we are interested in the discretization of the biharmonic equation on $C^0$-conforming multi-patch domains and we exploit the mortar technique to weakly enforce $C^1$-continuity across interfaces. In order to obtain discrete inf-sup stability, a particular choice for the Lagrange multiplier space is needed. Actually, we use as multipliers splines of degree reduced by two, w.r.t. the primal spline space, and with merged elements in the neighbourhood of the corners. In this framework, we are able to show optimal a priori error estimates. We also perform numerical tests that reflect theoretical results.

Published
2023

36. 4d N $$ \mathcal{N} $$ = 1 dualities from 5d dualities

Author

Stephane Bajeot and Sergio Benvenuti

Subjects
Brane Dynamics in Gauge Theories, Supersymmetry and Duality, Duality in Gauge Field Theories, Field Theories in Higher Dimensions, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We consider 5d KK dualities, that is multiple 5d gauge theories with the same 6d infinite coupling limit. We provide a prescription to associate 4d N $$ \mathcal{N} $$ = 1 quivers to the 5d dual quivers, such that the 4d quivers are also dual to each other. The 4d dualities are infrared dualities which can be checked matching global symmetry anomalies and in certain cases can be proven using basic Seiberg dualities sequentially. We also consider dualities obtained by Higgsing in two different ways the same 5d theory, in some simple examples.

Published
2024
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37. Breast cancer survivors’ opinion on personalizing endocrine therapy and developing informative tools

Author

Elie Rassy, Chiara Benvenuti, Sarra Akla, Antonio Di Meglio, Elise Martin, Julie Havas, André Rieutord, David Combarel, Léonor Fasse, Florian Scotté, Laure Guéroult Accolas, Guillemette Jacob, Anne Bergougnoux, Suzette Delaloge, Ines Vaz-Luis, and Barbara Pistilli

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Understanding breast cancer survivors’ perspectives is critical to personalizing endocrine therapy (ET) in the adjuvant setting. A nationwide survey among breast cancer survivors was proposed in France, in collaboration with patient advocacy organizations, to assess their perspectives on personalizing ET and developing dedicated informative tools. This survey explored patients’ preferences regarding ET intake schedule, formulation, presentation (color, taste, shape, size, design, and packaging), combination with agents targeting ET-related adverse events, and a mobile application to support them during ET. Of the 1103 individuals who started the survey, 939 (85.1%) were eligible for enrollment and completed the survey. The majority of the participants considered that a personalized ET should take into consideration the intake schedule (n = 974, 90.7%) and swallowable tablet formulation (n = 606, 64.5%), without a preference for ET presentation (n = 619; 65.9%). The majority of the participants expressed a willingness to participate in a potential clinical trial evaluating the combination of ET with agents targeting ET-related adverse events at the start of ET (n = 752, 80.1%) or in the case of major ET-related adverse events (n = 778, 82.8%). The primary considerations were to have an uncompromised ET efficacy and a guaranteed reduction of adverse events. Last, a dedicated mobile application was considered helpful by 665 participants (70.8%). Informative tools should focus on the recommendations for dealing with adverse events (n = 593, 63.2%), the impact on the patient’s daily life (n = 515, 54.9%), benefits (n = 504, 53.7%), and adverse events (n = 494, 52.6%) of ET. This survey paves the way for multimodal strategies that can include a personalized ET (e.g., ET in combination with agents targeting ET-related adverse events) and dedicated mobile applications to ultimately improve adherence.

Published
2024
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41. The Analytical Method algorithm for trigger primitives generation at the LHC Drift Tubes detector

Author

Abbiendi, G., Maestre, J. Alcaraz, Fernández, A. Álvarez, González, B. Álvarez, Amapane, N., Bachiller, I., Barcellan, L., Baldanza, C., Battilana, C., Bellato, M., Bencze, G., Benettoni, M., Beni, N., Benvenuti, A., Bergnoli, A., Ramos, L. C. Blanco, Borgonovi, L., Bragagnolo, A., Cafaro, V., Calderon, A., Calvo, E., Carlin, R., Montoya, C. A. Carrillo, Cavallo, F. R., Ruiz, J. M. Cela, Cepeda, M., Cerrada, M., Checchia, P., Ciano, L., Colino, N., Corti, D., Cotto, G., Crupano, A., Calzada, S. Cuadrado, Cuevas, J., Cuffiani, M., Dallavalle, G. M., Dattola, D., De La Cruz, B., Rodríguez, C. I. de Lara, De Remigis, P., Cid, C. Erice, Eliseev, D., Fabbri, F., Fanfani, A., Fasanella, D., Bedoya, C. F., de Trocóniz, J. F., del Val, D. Fernández, Menéndez, J. Fernández, Ramos, J. P. Fernández, Folgueras, S., Fouz, M. C., Ferrero, D. Francia, Romero, J. García, Gasparini, F., Gasparini, U., Giordano, V., Gonella, F., Caballero, I. González, Fernández, J. R. González, López, O. González, López, S. Goy, Gozzelino, A., Griggio, A., Grosso, G., Guandalini, C., Guiducci, L., Gulmini, M., Hebbeker, T., Hoepfner, K., Isocrate, R., Josa, M. I., Kiani, B., Holgado, J. León, Meo, S. Lo, Lusiani, E., Lunerti, L., Marcellini, S., Margoni, M., Mariotti, C., Martín, I. Martín, Morales, J. J. Martínez, Maselli, S., Masetti, G., Meneguzzo, A. T., Merschmeyer, M., Migliorini, M., Modenese, L., Molnar, J., Montecassiano, F., Martínez, J. Mora, Moran, D., Mukherjee, S., Navarrete, J. J., Navarria, F., Tobar, A. Navarro, Nowotny, F., Cortezón, E. Palencia, Passaseo, M., Pazzini, J., Pelliccioni, M., Perrotta, A., Philipps, B., Gomez, J. Piedra, Primavera, F., Pelayo, J. Puerta, Sánchez, J. C. Puras, Álvarez, C. Ramón, Redondo, I., Ferrero, D. D. Redondo, Reithler, H., Reyes-Almanza, R., Bouza, V. Rodríguez, Ronchese, P., Rossi, A. M., Rossin, R., Rotondo, F., Rovelli, T., Cruz, S. Sánchez, Navas, S. Sánchez, Sastre, J., Sharma, A., Simonetto, F., Rodríguez, A. Soto, Staiano, A., Szillasi, Z., Teyssier, D. F., Toniolo, N., Torromeo, G., Trapote, A., Trevisani, N., Triossi, A., Trocino, D., Ujvari, B., Umoret, G., Gómez, L. Urda, Uwe, B., Ventura, S., Villalba, C. Vico, Wiedenbeck, S., Zanetti, M., Zantis, F. P., Zilizi, G., Zotto, P., and Zucchetta, A.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The Compact Muon Solenoid (CMS) experiment prepares its Phase-2 upgrade for the high-luminosity era of the LHC operation (HL-LHC). Due to the increase of occupancy, trigger latency and rates, the full electronics of the CMS Drift Tube (DT) chambers will need to be replaced. In the new design, the time bin for the digitisation of the chamber signals will be of around 1~ns, and the totality of the signals will be forwarded asynchronously to the service cavern at full resolution. The new backend system will be in charge of building the trigger primitives of each chamber. These trigger primitives contain the information at chamber level about the muon candidates position, direction, and collision time, and are used as input in the L1 CMS trigger. The added functionalities will improve the robustness of the system against ageing. An algorithm based on analytical solutions for reconstructing the DT trigger primitives, called Analytical Method, has been implemented both as a software C++ emulator and in firmware. Its performance has been estimated using the software emulator with simulated and real data samples, and through hardware implementation tests. Measured efficiencies are 96 to 98\% for all qualities and time and spatial resolutions are close to the ultimate performance of the DT chambers. A prototype chain of the HL-LHC electronics using the Analytical Method for trigger primitive generation has been installed during Long Shutdown 2 of the LHC and operated in CMS cosmic data taking campaigns in 2020 and 2021. Results from this validation step, the so-called Slice Test, are presented., Comment: 16 pages, 11 figures

Published
2023
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43. 4d N=1 dualities from 5d dualities

Author

Bajeot, Stephane and Benvenuti, Sergio

Subjects
High Energy Physics - Theory
Abstract

We consider $5d$ KK dualities, that is multiple $5d$ gauge theories with the same $6d$ infinite coupling limit. We provide a prescription to associate $4d$ $N=1$ quivers to the $5d$ dual quivers, such that the $4d$ quivers are also dual to each other. The $4d$ dualities are infrared dualities which can be checked matching global symmetry anomalies and in certain cases can be proven using basic Seiberg dualities sequentially. We also consider dualities obtained by Higgsing in two different ways the same $5d$ theory, in some simple examples., Comment: 50 pages, many figures. V2: "n even" case added in sec. 5

Published
2022

44. Infrared phases of 3d massless CS-QCD and large $N_f$

Author

Arias-Tamargo, Guillermo, Benvenuti, Sergio, and Rodriguez-Gomez, Diego

Subjects
High Energy Physics - Theory, Condensed Matter - Strongly Correlated Electrons
Abstract

We compute anomalous dimensions of quartic operators which are singlets under the $\mathrm{U}(N_f)$ global symmetry in Yang-Mills theories with Chern-Simons level $k$ in three dimensions coupled to $N_f$ Dirac fermions. In order to have analytic control, we consider the regime $N_f\gg N_c\gg 1$, where the problem is reduced to the study of a flavor-adjoint and a flavor-singlet bilinears whose square give the quartic operators of interest. We provide evidence that these operators hit marginality, signaling instabilities which, for $\frac{2k}{N_f}<1$ suggest the spontaneous breaking of the global symmetry, and no symmetry breaking otherwise. For $k=N_f/2-1$ (the value corresponding to the domain walls of 4d QCD at $\theta=\pi$), the critical value $N_f^*$ is tantalizingly close to the lower end of the conformal window of QCD$_4$, suggesting a connection between conformal and global symmetry breaking in the 4d theory and in its domain walls. We also study, at $k=0$, other quartic operators containing a singlet when branched under $\mathrm{U}\left(\frac{N_f}{2}\right)\times \mathrm{U}\left(\frac{N_f}{2}\right)$, finding that they hit marginality precisely at the same point as their flavor-neutral cousins. Using the same technology we study bosonic CS-QCD$_3$, finding no hint of symmetry breaking where our analysis is applicable., Comment: 27 pages plus appendices, 4 figures

Published
2022

45. Digital innovations in breast cancer care: exploring the potential and challenges of digital therapeutics and clinical decision support systems

Author

Flavia Jacobs, Saverio D’Amico, Elena Zazzetti, Mariangela Gaudio, Chiara Benvenuti, Giuseppe Saltalamacchia, Riccardo Gerosa, Damiano Gentile, Angioletta Lasagna, Paolo Pedrazzoli, Corrado Tinterri, Armando Santoro, Rita De Sanctis, Matteo Della Porta, and Alberto Zambelli

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Modern healthcare is experiencing a significant transformation, utilizing technology to improve patient outcomes and make processes more efficient. Breast cancer, being the most commonly diagnosed cancer in women globally, requires innovative approaches for effective management. Digital Therapeutics (DTx) and Clinical Decision Support Systems (CDSSs) have emerged as pivotal technologies, offering personalized, patient-centered care and optimizing clinical decision-making. This review provides a comprehensive analysis of the applications, benefits, and challenges of these digital tools in breast cancer treatment. We examine DTx tools’ ability to offer real-time symptom monitoring, treatment adherence, psychological support, and lifestyle modification guidance. Simultaneously, the role of CDSSs in providing personalized treatment recommendations, early detection, data analysis, and enhancing multidisciplinary collaborations is evaluated. The challenges of implementing these technologies, such as data privacy, interoperability, and accessibility are also discussed, along with potential solutions. By exploring the current research findings, the review underscores the significant impact of DTx and CDSSs on patient outcomes, treatment efficiency, and overall quality of life. This manuscript concludes with a forward-looking perspective, emphasizing the importance of collaborative efforts to overcome obstacles and unlock the full potential of digital innovations in breast cancer oncology. Our analysis suggests that adopting these digital tools can lead to more holistic, efficient, and patient-centric cancer care, marking a significant shift in the paradigm of breast cancer management.

Published
2024
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46. Dysbiosis index and fecal concentrations of sterols, long-chain fatty acids and unconjugated bile acids in dogs with inflammatory protein-losing enteropathy

Author

Federica Cagnasso, Jan S. Suchodolski, Antonio Borrelli, Franca Borella, Enrico Bottero, Elena Benvenuti, Riccardo Ferriani, M. Katherine Tolbert, Chih-Chun Chen, Paula R. Giaretta, and Paola Gianella

Subjects
canine, fecal long-chain fatty acids, fecal sterols, fecal bile acids, dysbiosis, Microbiology, QR1-502
Abstract

IntroductionCanine protein-losing enteropathy (PLE) is a syndrome characterized by gastrointestinal loss of proteins. While fecal microbiome and metabolome perturbations have been reported in dogs with chronic enteropathy, they have not been widely studied in dogs with PLE. Therefore, the study aims were to investigate gut microbiome and targeted fecal metabolites in dogs with inflammatory PLE (iPLE) and evaluate whether treatment affects these changes at short-term follow-up.MethodsThirty-eight dogs with PLE and histopathological evidence of gastrointestinal inflammation and 47 healthy dogs were enrolled. Fecal samples were collected before endoscopy (T0) and after one month of therapy (T1). Microbiome and metabolome alterations were investigated using qPCR assays (dysbiosis index, DI) and gas chromatography/mass spectrometry (long-chain fatty acids, sterols, unconjugated bile acids), respectively.ResultsMedian (min-max) DI of iPLE dogs was 0.4 (−5.9 to 7.7) and was significantly higher (p < 0.0001) than median DI in healthy dogs [−2.0 (−6.0 to 5.3)]. No significant associations were found between DI and selected clinicopathological variables. DI did not significantly differ between T0 and T1. In iPLE dogs, at T0, myristic, palmitic, linoleic, oleic, cis-vaccenic, stearic, arachidonic, gondoic, docosanoic, erucic, and nervonic acids were significantly higher (p < 0.0001) than healthy dogs. In iPLE dogs, oleic acid (p = 0.044), stearic acid (p = 0.013), erucic acid (p = 0.018) and nervonic acid (p = 0.002) were significantly decreased at T1. At T0, cholesterol and lathosterol (p < 0.0001) were significantly higher in iPLE dogs compared to healthy dogs, while total measured phytosterols were significantly lower (p = 0.001). No significant differences in total sterols, total phytosterols and total zoosterols content were found at T1, compared to T0. At T0, total primary bile acids and total secondary bile acids did not significantly differ between healthy control dogs and iPLE dogs. No significant differences in fecal bile acid content were found at T1.DiscussionDysbiosis and lipid metabolism perturbations were observed in dogs with iPLE. Different therapeutic protocols lead to an improvement of some but not all metabolome perturbations at short-term follow-up.

Published
2024
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47. Evaluation of the beneficial effects of a GABA-based product containing Melissa officinalis on post-inflammatory irritable bowel syndrome: a preclinical study

Author

Elena Lucarini, Laura Benvenuti, Clelia Di Salvo, Vanessa D’Antongiovanni, Carolina Pellegrini, Giulia Valdiserra, Clara Ciampi, Luca Antonioli, Christian Lambiase, Lorenzo Cancelli, Antonio Grosso, Lorenzo Di Cesare Mannelli, Massimo Bellini, Carla Ghelardini, and Matteo Fornai

Subjects
irritable bowel syndrome, colitis, GABA, Melissa officinalis, abdominal pain, Therapeutics. Pharmacology, RM1-950
Abstract

IntroductionVisceral pain represents the most common digestive issue, frequently resulting from long-term inflammation, such as inflammatory bowel diseases. The lack of effective drugs prompted search of new therapeutic approaches. In this regard, gamma-aminobutyric acid (GABA) and Melissa officinalis (Mo) appear as excellent candidates as they were recognized to have several positive effects on the digestive system. The aim of this research was to evaluate the effects of a compound containing GABA and Mo (GABA-Mo 5:1) in inflammation-induced intestinal damage and visceral pain.MethodsColitis was induced in rats by intrarectal 2,4-dinitrobenzenesulfonic acid (DNBS) administration. DNBS-treated animals received GABA-Mo (80 mg/kg BID), starting 3 days before DNBS administration, until 14 days after colitis induction (preventive protocol), or starting 7 days after DNBS until day 21 (curative protocol). Visceral pain was assessed by measuring the viscero-motor response (VMR) and the abdominal withdrawal reflex (AWR) to colorectal distension on day 7, 14 (both protocols) and 21 (curative protocol) after DNBS administration.ResultsIn the preventive protocol, GABA-Mo reduced AWR at day 14 but had no effect on VMR. In the spinal cord, treatment with GABA-Mo significantly prevented microglia reactivity (Iba-1 positive cells). In the colon, the supplement significantly decreased malondialdehyde (MDA, index of oxidative stress) and IL-1β levels and counteracted the decreased expression of claudin-1. Moreover, GABA-Mo normalized the increased levels of plasma lipopolysaccharide binding protein (LBP, index of altered intestinal permeability). In the curative protocol, GABA-Mo significantly counteracted visceral hypersensitivity persistence in DNBS-treated animals (day 14 and 21). In the spinal cord, GABA-Mo significantly reduced GFAP positive cell density (astrocytes). Histological evaluations highlighted a mild but significant effect of GABA-Mo in promoting healing from DNBS-induced colon damage. Colonic MDA and myeloperoxidase (index of leukocyte infiltration) levels were reduced, while the decreased colonic claudin-1 expression was normalized. In addition, the increased levels of plasma LBP were normalized by GABA-Mo administration.DiscussionIn conclusion GABA-Mo, particularly in the curative protocol, was able to reduce visceral pain and intestinal inflammation, likely through a reinforcement of intestinal barrier integrity, thus representing a suitable approach for the management of abdominal pain, especially in the remission stages of colitis.

Published
2024
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48. Mönckeberg calcified sclerosis preventing the use of radial artery in myocardial revascularization surgery

Author

Luiz Alberto Benvenuti

Subjects
Arteriosclerosis, Coronary Artery Bypass, Mönckeberg Medial Calcific Sclerosis, Radial Artery, Medicine, Internal medicine, RC31-1245
Abstract

Figure 1 A – external and cross-sectional macroscopic view of the radial artery. Note thickening of the arterial wall; B – at histology, massive media calcification is evident (arrows), plus mild intimal fibrotic thickening (asterisks). Note internal elastic lamina (arrowheads), the internal limit of the medial layer (HE stain).: Arteriosclerosis, i.e., “hardening of the arteries”, is currently subdivided into atherosclerosis, Mönckeberg calcified sclerosis (MCS), and arteriolosclerosis. MCS was first described in 1903, characterized by calcific deposits affecting only the tunica media of large and medium-sized muscular arteries without significant luminal stenosis. However, MCS can coexist with classical atherosclerosis, characterized by atheroma plaques in the intima. MCS is rarely seen in patients under the 5th decade of life and is associated with the presence of diabetes mellitus and/or chronic kidney disease. The etiology and pathogenesis of MCS are currently poorly understood.1,2 The use of arterial grafts in myocardial revascularization surgery is associated with a lower rate of adverse cardiac events and a higher rate of patency of the grafts at 5 years of follow-up. Besides the left internal thoracic artery, the right one and the radial artery have been used, particularly when complete revascularization is pursued in patients with multivessel coronary artery disease.3 However, when planning myocardial revascularization, surgeons should be aware that pathological alterations, particularly arteriosclerosis, can affect arterial conduits. Concerning the radial artery, there are previous reports of MCS preventing arterial catheterization and, more importantly, preventing its use as an arterial graft in myocardial revascularization surgery.4,5 A 69-year-old man presented to our hospital with unstable angina. He had systemic hypertension and type II insulin-dependent diabetes mellitus. A previous myocardial infarction occurred 25 years ago, treated with coronary angioplasty and a stent position in the right coronary artery. He was previously submitted to amputation of several toes. No renal dysfunction was detected during the current hospitalization. Coronary angiography demonstrated severe obstructive atherosclerotic lesions in the left trunk and anterior descending coronary artery, plus occlusive thrombosis of the right coronary artery. Myocardial revascularization surgery was planned with the use of internal thoracic and radial arteries. However, at the operation table, the surgeon noticed the radial artery was severe and diffusely calcified and decided to abort its use. The revascularization surgery was successfully concluded using the left internal thoracic artery and two saphenous vein grafts. The Pathology laboratory received a 16 cm long artery presenting an external diameter ranging from 0.4 to 0.6 cm. The artery was diffusely hardened and presented a calcified aspect. After chemical decalcification, the artery was cross-sectioned and moderate to severe thickening of the wall was noticed (Figure 1A). At histology, there was massive calcification of the media and mild multifocal, fibrotic thickening of the intima (Figure 1B). There were no lipid deposits or calcification of the intima. We concluded for severe MCS plus mild atherosclerosis.

Published
2024
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