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198 results on '"Benzie, Iris F."'

17. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes.

Author

Chan, Sze Wa, Chu, Tanya T. W., Choi, Siu Wai, Benzie, Iris F. F., and Tomlinson, Brian

Abstract

Bilberry (Vaccinium myrtillus L.) is one of the richest natural sources of anthocyanins which are powerful antioxidants and reported to have antiinflammatory, antidyslipidemic, antihypertensive, and hypoglycemic effects. The objective of this study was to assess the effect of bilberry supplementation on biomarkers of glycemic control, lipid profile, antioxidant, and inflammatory status in patients with type 2 diabetes in a randomized, double-blind, placebo-controlled cross-over study. Twenty patients were randomized to receive either bilberry supplementation (1.4 g/day of extract) daily for 4 weeks followed by 6 weeks of washout and then an additional 4 weeks of matching placebo or vice versa. Blood pressure, metabolic parameters, antioxidant status, and oxidative stress were measured before and after each period. Results showed no effect on body weight, blood pressure, or lipid profile. HbA1c was reduced by 0.31 ± 0.58% during bilberry supplementation, but this change was not significantly different from that with placebo. Antioxidant status, oxidative stress, and inflammatory status showed no significant differences across treatments. This short-term study of bilberry supplementation did not show significant effects on cardiovascular risk factors or antioxidant status, but the tendency for improved glycemic control may suggest a longer treatment period may be effective in diabetic patients. [ABSTRACT FROM AUTHOR]

Published
2021
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19. Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi;Fructus barbarum L.)

Author

Benzie, Iris F. F., Chung, Wai Y., Wang, Junkuan, Richelle, Myriam, Bucheli, Peter, Benzie, Iris F. F., Chung, Wai Y., Wang, Junkuan, Richelle, Myriam, and Bucheli, Peter

Abstract

The carotenoid zeaxanthin is concentrated within the macula. Increased macular zeaxanthin is suggested to lower the risk of age-related macular degeneration. The small red berry, wolfberry (Fructus barbarum L.; Gou Qi Zi and Kei Tze), is one of the richest natural sources of zeaxanthin. However, carotenoid bioavailability is low, and food-based products with enhanced bioavailability are of interest. The present study investigated zeaxanthin bioavailability from three wolfberry formulations. Berries were homogenised in hot (80°C) water, warm (40°C) skimmed milk and hot (80°C) skimmed milk, with freeze drying of each preparation into a powdered form. A zeaxanthin-standardised dose (15mg) of each was consumed, in randomised order, together with a standardised breakfast by twelve healthy, consenting subjects in a cross-over trial, with a 3-5-week washout period between treatments. Blood samples were taken via a venous cannula immediately before (fasting) and 2, 4, 6, 7, 8 and 10h post-ingestion. Zeaxanthin concentration in the triacylglycerol-rich lipoprotein fraction of plasma was measured by HPLC. Results showed that triacylglycerol-rich lipoprotein zeaxanthin peaked at 6h post-ingestion for all formulations. Zeaxanthin bioavailability from the hot milk formulation was significantly higher (p<0·001) than from the others. Mean area under the curve (n 12) results were 9·73 (sem 2·45), 3·24 (sem 0·72) and 3·14 (sem 1·09) nmol×h/l for the hot milk, warm milk and hot water formulations, respectively. Results showed clearly that homogenisation of wolfberry in hot skimmed milk results in a formulation that has a 3-fold enhanced bioavailability of zeaxanthin compared with both the ‘classical' hot water and warm skimmed milk treatment of the berries

Published
2017

22. Protective effect of caspase inhibition on compression-induced muscle damage

Author

Teng, Bee T, Tam, Eric W, Benzie, Iris F, and Siu, Parco M

Subjects
Male, Rats, Sprague-Dawley, Random Allocation, Neuroprotective Agents, Compressive Strength, Muscular Diseases, Caspases, Animals, Apoptosis, Caspase Inhibitors, Skeletal Muscle and Exercise, Amino Acid Chloromethyl Ketones, Rats
Abstract

There are currently no effective therapies for treating pressure-induced deep tissue injury. This study tested the efficacy of pharmacological inhibition of caspase in preventing muscle damage following sustained moderate compression. Adult Sprague-Dawley rats were subjected to prolonged moderate compression. Static pressure of 100 mm Hg compression was applied to an area of 1.5 cm2 in the tibialis region of the right limb of the rats for 6 h each day for two consecutive days. The left uncompressed limb served as intra-animal control. Rats were randomized to receive either vehicle (DMSO) as control treatment (n =8) or 6 mg kg⁻¹ of caspase inhibitor (z-VAD-fmk; n =8) prior to the 6 h compression on the two consecutive days.Muscle tissues directly underneath the compression region of the compressed limb and the same region of control limb were harvested after the compression procedure.Histological examination and biochemical/molecular measurement of apoptosis and autophagy were performed. Caspase inhibition was effective in alleviating the compression-induced pathohistology of muscle. The increases in caspase-3 protease activity, TUNEL index, apoptotic DNA fragmentation and pro-apoptotic factors (Bax, p53 and EndoG) and the decreases in anti-apoptotic factors (XIAP and HSP70) observed in compressed muscle of DMSO-treated animals were not found in animals treated with caspase inhibitor. The mRNA content of autophagic factors (Beclin-1, Atg5 and Atg12) and the protein content of LC3, FoxO3 and phospho-FoxO3 that were down-regulated in compressed muscle of DMSO-treated animals were all maintained at their basal level in the caspase inhibitor treated animals. Our data provide evidence that caspase inhibition attenuates compression-induced muscle apoptosis and maintains the basal autophagy level. These findings demonstrate that pharmacological inhibition of caspase/apoptosis is effective in alleviating muscle damage as induced by prolonged compression.

Published
2011

38. Effects of Incense Smoke on Human Lymphocyte DNA

Author

Tong Szeto, Yim, primary, Sok Wa Leong, Kosca, additional, Keong Lam, Kason, additional, Min Min Hong, Cynthia, additional, Kai Mui Lee, Daphne, additional, Teng Fun Chan, Yui, additional, and Benzie, Iris F. F., additional

Published
2009
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39. Safety and efficacy ofGanoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: A double-blind, randomized, placebo-controlled pilot trial

Author

Li, Edmund K., primary, Tam, Lai-Shan, additional, Wong, Chun Kwok, additional, Li, Wai Ching, additional, Lam, Christopher W. K., additional, Wachtel-Galor, Sissi, additional, Benzie, Iris F. F., additional, Bao, Yi Xi, additional, Leung, Ping Chung, additional, and Tomlinson, Brian, additional

Published
2007
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48. Assessing Age-Related Changes in Antioxidant Status.

Author

Walker, John M., Barnett, Yvonne A., Barnett, Christopher R., Benzie, Iris F. F., and Strain, John J.

Abstract

There is accumulating evidence that oxidative damage to protein, lipid, carbohydrate and DNA is an important cause and/or effect of cellular and subcellular changes associated with disease, and is responsible for at least some of the physiological, but ultimately fatal, changes that accompany aging (1-8). Advancing age brings increasing risk of chronic degenerative disease including cancer, cardiovascular disease, cataracts, and dementia (1-6, 8).Immune status declines, with consequent increased risk of infection and, owing to a combination of physical and socioeconomic factors, nutritional status is often poor in the elderly, increasing the likelihood of poor antioxidant status (9). [ABSTRACT FROM AUTHOR]

Published
2000
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