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9. Double Trouble: Association of Malignant Melanoma with Sporadic and Genetic Forms of Parkinson’s Disease and Asymptomatic Carriers of Related Genes: A Brief Report

Author

Koros, Christos, primary, Simitsi, Athina-Maria, additional, Bougea, Anastasia, additional, Papagiannakis, Nikolaos, additional, Antonelou, Roubina, additional, Pachi, Ioanna, additional, Angelopoulou, Efthalia, additional, Prentakis, Andreas, additional, Zachou, Athena, additional, Chrysovitsanou, Chrysa, additional, Beratis, Ion, additional, Fragkiadaki, Stella, additional, Kontaxopoulou, Dionysia, additional, Eftymiopoulou, Efthymia, additional, Stanitsa, Evangelia, additional, Potagas, Constantin, additional, Papageorgiou, Sokratis G., additional, Karavasilis, Efstratios, additional, Velonakis, Georgios, additional, Prassopoulos, Vasilios, additional, Geronicola-Trapali, Xenia, additional, and Stefanis, Leonidas, additional

Published
2023
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10. Serum Uric Acid as a Putative Biomarker in Prodromal Parkinson’s Disease: Longitudinal Data from the PPMI Study

Author

Koros, Christos, primary, Simitsi, Athina-Maria, additional, Papagiannakis, Nikolaos, additional, Bougea, Anastasia, additional, Prentakis, Andreas, additional, Papadimitriou, Dimitra, additional, Pachi, Ioanna, additional, Beratis, Ion, additional, Stanitsa, Evangelia, additional, Angelopoulou, Efthalia, additional, Antonelou, Roubina, additional, Bregianni, Marianna, additional, Lourentzos, Konstantinos, additional, Papageorgiou, Sokratis G., additional, Bonakis, Anastasios, additional, Trapali, Xenia Geronicola, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional

Published
2023
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12. Impact ofAPOEGenotype on Cognition in Idiopathic and Genetic Forms of Parkinson's Disease

Author

Koros, Christos, primary, Brockmann, Kathrin, additional, Simitsi, Athina‐Maria, additional, Bougea, Anastasia, additional, Liu, Hui, additional, Hauser, Ann‐Kathrin, additional, Schulte, Claudia, additional, Lerche, Stefanie, additional, Pachi, Ioanna, additional, Papagiannakis, Nikolaos, additional, Antonelou, Roubina, additional, Zahou, Athina, additional, Wurster, Isabel, additional, Efthymiopoulou, Efthymia, additional, Beratis, Ion, additional, Maniati, Matina, additional, Moraitou, Marina, additional, Michelakakis, Helen, additional, Paraskevas, Georgios, additional, Papageorgiou, Sokratis G., additional, Potagas, Constantin, additional, Papadimitriou, Dimitra, additional, Bozi, Maria, additional, Stamelou, Maria, additional, Gasser, Thomas, additional, and Stefanis, Leonidas, additional

Published
2023
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14. The Effects of a Clinical Prevention Program on Bullying, Victimization, and Attitudes toward School of Elementary School Students

Author

Tsiantis, Alkis Constantine J., Beratis, Ion N., Syngelaki, Eva M., Stefanakou, Anna, Asimopoulos, Charisios, Sideridis, Georgios D., and Tsiantis, John

Abstract

The purpose of the present study was to evaluate a bullying prevention program that involved eleven 90-minute, highly structured workshops conducted at the classroom level on a weekly basis. The intervention aimed to increase student awareness of bullying and its impact, increase empathy toward victims, and enhance positive attitudes toward school and academic achievement. Participants were 666 students who were selected from 20 elementary schools using stratified random-sampling procedures from a large metropolitan area of southern Greece. Students were randomly assigned to experimental and control groups and were provided measures of bullying and victimization behaviors at pretest and posttest (Olweus, 1996). Results indicated that there were statistically significant decreases in bullying and victimization behaviors from pretest to posttest. Specifically, victimization rates in the experimental group were reduced from pretest to posttest by 55.4%. The respective decreases in the control group were 23.3%. Similarly, bullying rates decreased by 55.6% at posttest compared with pretest in the experimental group, and the combined type decreased by 66.7%. Furthermore, a latent class analysis provided qualitative means on the specific categories in which decreases of negative behaviors were observed. Additional positive effects were observed with increases in positive attitudes toward school (school liking). We conclude that the current prevention program effectively reduced bullying and victimization in the elementary schools in Greece and holds promise for influencing the overall school experience.

Published
2013

16. Frontotemporal dementia spectrum: first genetic screen in a Greek cohort

Author

Ramos, Eliana Marisa, Koros, Christos, Dokuru, Deepika Reddy, Van Berlo, Victoria, Kroupis, Christos, Wojta, Kevin, Wang, Qing, Andronas, Nikolaos, Matsi, Stavroula, Beratis, Ion N., Huang, Alden Y., Lee, Suzee E., Bonakis, Anastasios, Florou-Hatziyiannidou, Chryseis, Fragkiadaki, Stella, Kontaxopoulou, Dionysia, Agiomyrgiannakis, Dimitrios, Kamtsadeli, Vasiliki, Tsinia, Niki, Papastefanopoulou, Vasiliki, Stamelou, Maria, Miller, Bruce L., Stefanis, Leonidas, Papatriantafyllou, John D., Papageorgiou, Sokratis G., and Coppola, Giovanni

Published
2019
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17. APOE Allele Frequency in Southern Greece: Exploring the Role of Geographical Gradient in the Greek Population

Author

Papastefanopoulou, Vasiliki, primary, Stanitsa, Evangelia, additional, Koros, Christos, additional, Simoudis, Aimilios, additional, Florou-Hatziyiannidou, Chryseis, additional, Beratis, Ion, additional, Antonelou, Roubina, additional, Andronas, Nikolaos, additional, Voskou, Panagiota, additional, Angelopoulou, Efthalia, additional, Papatriantafyllou, John D., additional, Stefanis, Leonidas, additional, Kroupis, Christos, additional, and Papageorgiou, Sokratis G., additional

Published
2022
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18. Prosopagnosia, Other Specific Cognitive Deficits, and Behavioral Symptoms: Comparison between Right Temporal and Behavioral Variant of Frontotemporal Dementia

Author

Koros, Christos, primary, Beratis, Ion, additional, Matsi, Stavroula, additional, Bougea, Anastasia, additional, Bonakis, Anastasios, additional, Papatriantafyllou, Ioannis, additional, Angelopoulou, Efthalia, additional, Kapaki, Elisabeth, additional, Stefanis, Leonidas, additional, and Papageorgiou, Sokratis G., additional

Published
2022
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19. Impact ofAPOEgenotype on cognition in idiopathic and genetic forms of Parkinson’s disease

Author

Koros, Christos, primary, Brockmann, Kathrin, additional, Simitsi, Athina-Maria, additional, Bougea, Anastasia, additional, Liu, Hui, additional, Hauser, Ann-Kathrin, additional, Schulte, Claudia, additional, Lerche, Stefanie, additional, Pachi, Ioanna, additional, Papagiannakis, Nikolaos, additional, Antonelou, Roubina, additional, Zahou, Athina, additional, Wurster, Isabel, additional, Efthymiopoulou, Efthymia, additional, Beratis, Ion, additional, Maniati, Matina, additional, Moraitou, Marina, additional, Michelakakis, Helen, additional, Paraskevas, Georgios, additional, Papageorgiou, Sokratis G., additional, Potagas, Constantin, additional, Papadimitriou, Dimitra, additional, Bozi, Maria, additional, Stamelou, Maria, additional, Gasser, Thomas, additional, and Stefanis, Leonidas, additional

Published
2022
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26. Neuropsychology in Greece: Results from a survey of practicing professionals.

Author

Liozidou, Athanasia, Traikapi, Artemis, Stanitsa, Evangelia, Kontaxopoulou, Dionysia, Fragkiadaki, Stella, Beratis, Ion, Nunez-Fernandez, Silvia, Rivera, Diego, Kingsley, Kristine, and Arango-Lasprilla, Juan Carlos

Subjects
NEUROPSYCHOLOGY, PROFESSIONAL practice, PROFESSIONAL associations, HOSPITALS, PSYCHOLOGISTS, APHASIC persons
Abstract

Neuropsychology is a fast-growing specialty in Greece. This study surveyed the status of neuropsychologists in Greece investigating several aspects of the profession. An online-based questionnaire collected data from December 2019 to February 2020. A total of 133 participants specialized in neuropsychology were included in the final sample: 81% of the participants were women with a mean age of 35 years. In the total sample, 25.8% of the participants reported working in the hospital system, 18.5% in the university or college, and 17.7% in a private practice job. Greek professionals cited to engage actively in assessment (87.9%), in research (65.1%), in rehabilitation (47.7%), and teaching (30.2%). Professionals primarily declared to assess individuals with dementia (80.3%), depression (47.7%), and stroke (44.0%), and they reported neurologists, psychiatrists and psychologists as their leading sources of referrals. The top five perceived barriers to the field include the lack of recognized specialty (75.9%), the lack of clinical training opportunities (63.9%), the lack of strong professional associations (57.9%), the lack of access to neuropsychological instruments (57.9%) and the lack of willingness to collaborate between professionals (48.9%). The average monthly income of professionals represents a ratio of 0.76 in comparison to that of other scientists in the country and is the lowest reported among other countries. Despite the significant development of the profession, it is essential to create more clinical training opportunities, apply practices systematically to diverse populations, redefine the specialty of neuropsychology in the national health system of the country, and advocate for the profession. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Asymptomatic carriers of the p.A53T SNCA mutation: data from the PPMI study

Author

Simitsi, Athina Maria, primary, Koros, Christos, additional, Stamelou, Maria, additional, Beratis, Ion, additional, Efthymiopoulou, Efthymia, additional, Papadimitriou, Dimitra, additional, Bougea, Anastasia, additional, Picillo, Marina, additional, Stanitsa, Evangelia, additional, Papagiannakis, Nikolaos, additional, Antonelou, Roubina, additional, Pachi, Ioanna, additional, Papageorgiou, Sokratis G, additional, Barone, Paolo, additional, and Stefanis, Leonidas, additional

Published
2021
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33. Serum uric acid and total bilirubin as putative biomarkers of resistance in Prodromal Parkinson’s disease: Longitudinal data from the PPMI study

Author

Koros, Christos, primary, Simitsi, Athina-Maria, additional, Bougea, Anastasia, additional, Papagiannakis, Nikolaos, additional, Prentakis, Andreas, additional, Papadimitriou, Dimitra, additional, Pachi, Ioanna, additional, Angelopoulou, Efthalia, additional, Beratis, Ion, additional, Efthymiopoulou, Efthymia, additional, Lourentzos, Konstantinos, additional, Bozi, Maria, additional, Papageorgiou, Sokratis G., additional, Trapali, Xenia Geronicola, additional, Bonakis, Anastasios, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional

Published
2021
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34. Effect of Apolipoprotein E4 on the Driving Behavior of Patients with Amnestic Mild Cognitive Impairment or Mild Alzheimer’s Disease Dementia

Author

Stanitsa, Evangelia, primary, Economou, Alexandra, additional, Beratis, Ion, additional, Kontaxopoulou, Dionysia, additional, Fragkiadaki, Stella, additional, Papastefanopoulou, Vicky, additional, Pavlou, Dimosthenis, additional, Papantoniou, Panagiotis, additional, Kroupis, Christos, additional, Papatriantafyllou, John, additional, Stefanis, Leonidas, additional, Yannis, George, additional, and Papageorgiou, Sokratis G., additional

Published
2021
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36. Apathy: an underestimated feature in GBA and LRRK2 non-manifesting mutation carriers

Author

Pachi, Ioanna, primary, Koros, Christos, additional, Simitsi, Athina M, additional, Papadimitriou, Dimitra, additional, Bougea, Anastasia, additional, Prentakis, Andreas, additional, Papagiannakis, Nikolaos, additional, Bozi, Maria, additional, Antonelou, Roubina, additional, Angelopoulou, Efthalia, additional, Beratis, Ion, additional, Stamelou, Maria, additional, Trapali, Xenia Geronicola, additional, Papageorgiou, Sokratis G., additional, and Stefanis, Leonidas, additional

Published
2021
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37. Serum Uric Acid in LRRK2 Related Parkinson’s Disease: Longitudinal Data from the PPMI Study

Author

Bougea, Anastasia, primary, Koros, Christos, additional, Papagiannakis, Nikolaos, additional, Simitsi, Athina-Maria, additional, Prentakis, Andreas, additional, Papadimitriou, Dimitra, additional, Pachi, Ioanna, additional, Antonelou, Roubina, additional, Angelopoulou, Efthalia, additional, Beratis, Ion, additional, Bozi, Maria, additional, Papageorgiou, Sokratis G., additional, Trapali, Xenia Geronicola, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional

Published
2021
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39. Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson’s Disease: Data from the PPMI Study

Author

Koros, Christos, primary, Simitsi, Athina-Maria, additional, Papadimitriou, Dimitra, additional, Bougea, Anastasia, additional, Prentakis, Andreas, additional, Papagiannakis, Nikolaos, additional, Pachi, Ioanna, additional, Bozi, Maria, additional, Antonelou, Roubina, additional, Angelopoulou, Efthalia, additional, Beratis, Ion, additional, Papageorgiou, Sokratis G., additional, Trapali, Xenia Geronicola, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional

Published
2020
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40. Impact of APOE Genotype on Cognition in Idiopathic and Genetic Forms of Parkinson's Disease.

Author

Koros, Christos, Brockmann, Kathrin, Simitsi, Athina‐Maria, Bougea, Anastasia, Liu, Hui, Hauser, Ann‐Kathrin, Schulte, Claudia, Lerche, Stefanie, Pachi, Ioanna, Papagiannakis, Nikolaos, Antonelou, Roubina, Zahou, Athina, Wurster, Isabel, Efthymiopoulou, Efthymia, Beratis, Ion, Maniati, Matina, Moraitou, Marina, Michelakakis, Helen, Paraskevas, Georgios, and Papageorgiou, Sokratis G.

Published
2023
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41. DaTSCAN (123I-FP-CIT SPECT) imaging in early versus mid and late onset Parkinson's disease: Longitudinal data from the PPMI study

Author

Koros, Christos Simitsi, Athina-Maria Prentakis, Andreas and Papagiannakis, Nikolaos Bougea, Anastasia Pachi, Ioanna and Papadimitriou, Dimitra Beratis, Ion Papageorgiou, Sokratis G. and Stamelou, Maria Trapali, Xenia Geronicola Stefanis, Leonidas

Abstract

Introduction: It has been reported that early onset Parkinson’s Disease (PD) patients have a less profound dopaminergic degeneration. The aim of the current study was to determine whether there are longitudinal differences in dopaminergic denervation [signal reduction in 123I-FP-CIT SPECT] in early versus mid and late onset PD. Methods: DaTSCAN (123I-FP-CIT SPECT) imaging was acquired at Parkinson’s Progression Markers Initiative (PPMI) imaging centers and sent to the imaging core for calculation of striatal binding ratios. Data from the PPMI database of 58 early de novo PD patients (age 50 years). Results: Although raw striatal binding ratios were higher in early onset versus mid/late onset PD, especially on the ipsilateral side, such differences were not observed, and were in fact reversed in the contralateral putamen, after age correction. The rate of signal decline was similar between the two groups. Interestingly, based on both raw and age-adjusted data, caudate nucleus and putamen asymmetry (contralateral/ipsilateral ratio) was more pronounced in early onset PD. Striatal asymmetry also significantly correlated with age at onset as a continuous variable. Conclusion: Early onset PD patients exhibited similar rates of decline of dopaminergic denervation compared to mid/late onset PD. These results are not supportive of a more benign disease in this subgroup. The more pronounced asymmetry in early onset PD may however signify a qualitatively different pattern of neurodegeneration compared to mid/late onset PD.

Published
2020

42. Serum Uric Acid Level as a Biomarker in Idiopathic and Genetic (p.A53T Alpha-Synuclein Carriers) Parkinson?s Disease: Data from the PPMI Study

Author

Koros, Christos Simitsi, Athina-Maria Papadimitriou, Dimitra and Bougea, Anastasia Prentakis, Andreas Papagiannakis, Nikolaos and Pachi, Ioanna Bozi, Marria Antonelou, Roubina Angelopoulou, Efthalia Beratis, Ion Papageorgiou, Sokratis G. Trapali, Xenia Geronicola Stamelouaef, Maria Stefanis, Leonidas

Abstract

Background: Blood uric acid level represents an emerging biomarker in Parkinson's disease (PD). Whether uric acid levels change in genetic forms of PD is just beginning to be explored. Objective: The aim of the present study was to assess differences in serum uric acid level among PD patients harboring the p.A53T mutation in the alpha-synuclein gene, idiopathic PD, and healthy controls. Methods: Longitudinal 5-year serum uric acid measurement data of 369 de novo idiopathic PD patients and 174 age- and gender-matched healthy controls have been downloaded from the Parkinson's Progression Markers Initiative (PPMI) database. Furthermore, we assessed baseline serum uric acid measurements of 24 p.A53T alpha-synuclein PD patients enrolled in PPMI and followed in our site as compared to 24 age-, gender- and disease duration-matched sporadic PD patients and 24 healthy controls. Results: Longitudinal serum uric acid measurements did not differ statistically between idiopathic PD patients and healthy controls (despite a trend for lower uric acid in the PD group) (p = 0.879). This was also true when male and female subgroups were assessed separately. The p.A53T SNCA mutation carrier PD group exhibited lower baseline serum uric acid level as compared to their matched healthy controls (p = 0.025). Conclusion: In the present study we did not replicate the established lower serum uric acid measurements in PD patients as compared to controls using PPMI data, possibly due to the fact that PD patients in baseline visit were de novo and the average disease duration was shorter than that observed in most epidemiological PD studies. The faster progression rate and increased disease severity in p.A53T PD possibly correlate with the lower serum uric acid observed in this subgroup.

Published
2020

43. Predictors of accidents in people with mild cognitive impairment, mild dementia due to Alzheimer's disease and healthy controls in simulated driving

Author

Economou, Alexandra (author), Pavlou, Dimosthenis (author), Beratis, Ion (author), Andronas, Nikolaos (author), Papadimitriou, E. (author), Papageorgiou, Sokratis G. (author), Yannis, George (author), Economou, Alexandra (author), Pavlou, Dimosthenis (author), Beratis, Ion (author), Andronas, Nikolaos (author), Papadimitriou, E. (author), Papageorgiou, Sokratis G. (author), and Yannis, George (author)

Abstract

Objectives: To examine the driving variables that predict accident probability in mild dementia due to Alzheimer's disease (AD), mild cognitive impairment (MCI) and healthy older control drivers in simulated driving. To compare the three groups in mean performance and in frequency of scores exceeding 1.5 SD from the mean. Methods/Design: Participants were 37 drivers with MCI, 16 drivers with AD, and 21 control drivers over the age of 52. Driving measures were derived from four rural driving conditions: moderate traffic without and with distraction and high traffic without and with distraction. The measures were z-transformed based on the performance of 90 control drivers of different ages. Two unexpected incidents occurred per condition, requiring the sudden breaking to avoid an accident. Results: Drivers with AD showed significantly lower average speed, speed variability, greater headway distance, headway variability and average reaction time (RT) than control drivers. Drivers with MCI showed significantly lower average speed, greater headway distance and average RT than control drivers in the two conditions of distraction. No differences were found in accident probability. Drivers with AD had more deviant scores than both control drivers and drivers with MCI in most comparisons. Predictors of accident probability were average RT, speed variability and lateral position variability but MCI and AD status were not significant predictors in any of the regression models. Conclusions: Despite significant differences in performance, drivers with MCI and AD did not differ in accident probability from control drivers. An individualized approach of examining individual driving performance is recommended., Safety and Security Science

Published
2020
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45. Effect of initiation-inhibition and handedness on the patterns of the P50 event-related potential component: a low resolution electromagnetic tomography study

Author

Capsalis Christos N, Maganioti Argiro E, Hountala Chrissanthi, Nanou Eleni D, Rabavilas Andreas, Beratis Ion N, Papadimitriou George N, and Papageorgiou Charalabos

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Recent research recognizes the association between handedness, linguistic processes and cerebral networks subserving executive functioning, but the nature of this association remains unclear. Since the P50 event related potential (ERP) is considered to reflect thalamocortical processes in association with working memory (WM) operation the present study focuses on P50 patterns elicited during the performance of a linguistic related executive functioning test in right- and left-handers. Methods In 64 young adults with a high educational level (33 left-handed) the P50 event-related potential was recorded while performing the initiation and inhibition condition of a modified version of the Hayling Sentence Completion test adjusted to induce WM. The manual preference of the participants was evaluated with the use of the Edinburgh Handedness Inventory (EHI). Results P50 showed greater amplitudes in left- than in right-handers, mainly in frontal leads, in the initiation condition. Reduced amplitudes in inhibition compared to initiation condition were observed in left-handers. Low Resolution Electromagnetic Tomography (LORETA) analysis showed lower frontal lobe activation in the inhibition than in the initiation condition in both right- and left-handers. Also, LORETA yielded that right-handers exhibited greater activation in the inhibition condition than left-handers. Additionally, LORETA showed assymetrical hemispheric activation patterns in right-handers, in contrast to symmetrical patterns observed in left-handers. Higher P50 amplitudes were recorded in right-hemisphere of right-handers in the initiation condition. Conclusion Brain activation, especially the one closely related to thalamocortical function, elicited during WM operation involving initiation and inhibition processes appears to be related to handedness.

Published
2009
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46. Selective cognitive impairment and hyposmia in p.A53T SNCA PD vs typical PD

Author

Koros, Christos Stamelou, Maria Simitsi, Athina Beratis, Ion and Papadimitriou, Dimitra Papagiannakis, Nikolaos Fragkiadaki, Stella Kontaxopoulou, Dionysia Papageorgiou, Sokratis G. and Stefanis, Leonidas

Abstract

ObjectiveTo evaluate nonmotor symptoms in early SNCA/p.A53T Parkinson disease (PD) (A53T PD) compared to typical PD (tPD).MethodsThe presence of hyposmia, neuropsychiatric, dysautonomic, and sleep disturbances was assessed by standardized questionnaires and validated scales in 18 patients with A53T PD and 18 patients with tPD, matched for age, sex, and disease duration. All patients were enrolled into the Parkinson's Progression Markers Initiative study.ResultsThe levodopa equivalent daily dose was higher in the A53T PD (p = 0.018) group vs the tPD group. Scores on the University of Pennsylvania Smell Identification Test (p = 0.001), Benton Judgement of Line Orientation test (p = 0.001), Letter Number Sequencing Test (p = 0.002), and phonemic verbal fluency (p = 0.002) were lower in the A53T PD group vs the tPD group. In contrast, overall cognition, verbal memory, and semantic fluency were similar between groups.ConclusionThe observed selective cognitive impairment reflecting frontal-parietal network dysfunction, together with impaired olfaction, define a set of nonmotor dysfunctions related to A53T PD. These results have implications for the prognosis of patients with A53T PD. Moreover, as the archetypal -synucleinopathy, such results may give insights into tPD.

Published
2018

47. 123I-FP-CIT SPECT [(123) I-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T alpha-synuclein Parkinson’s disease cohort versus Parkinson’s disease

Author

Koros, Christos Simitsi, Athina Prentakis, Andreas Beratis, Ion Papadimitriou, Dimitra Kontaxopoulou, Dionysia and Fragkiadaki, Stella Papagiannakis, Nikolaos Seibyl, John and Marek, Kenneth Papageorgiou, Sokratis G. Trapali, Xenia Geronicola Stamelou, Maria Stefanis, Leonidas

Abstract

Background: The p.A53T point mutation in the alpha-synuclein gene (SNCA) is a rare but highly relevant cause of autosomal dominant Parkinson’s disease (PD). Objectives: The objective of this study was to assess striatal dopaminergic denervation in a cohort of symptomatic carriers of the p.A53T SNCA mutation as compared to PD patients. Methods: Data from the Parkinson’s Progression Markers Initiative database of 11 symptomatic p.A53T SNCA mutation carriers who underwent 123I-FP-CIT SPECT [(123) I-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] imaging at our site were compared with those of 33 age-, sex-, and disease duration-matched PD patients. Results: The p.A53T mutation carriers had significantly lower caudate nucleus binding ratio both contralaterally and ipsilaterally to the most affected side (P = .002 and P = .006) and a decreased contralateral caudate/putamen signal ratio (P = .007) as compared to PD. A similar degree of striatal asymmetry was observed in both subgroups. No correlation between scores in neuropsychological tests and caudate nucleus dopaminergic denervation could be demonstrated. Conclusions: PD patients harboring the p.A53T SNCA mutation show evidence of a more severe nigrostriatal denervation, especially evident in the caudate nucleus. The lack of significant differences in the putaminal binding ratios may reflect a floor effect or a true preferential targeting of the caudate terminals in p.A53T SNCA-associated PD. (c) 2018 International Parkinson and Movement Disorder Society

Published
2018

48. 123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease

Author

Koros, Christos, primary, Simitsi, Athina, additional, Prentakis, Andreas, additional, Beratis, Ion, additional, Papadimitriou, Dimitra, additional, Kontaxopoulou, Dionysia, additional, Fragkiadaki, Stella, additional, Papagiannakis, Nikolaos, additional, Seibyl, John, additional, Marek, Kenneth, additional, Papageorgiou, Sokratis G., additional, Trapali, Xenia Geronicola, additional, Stamelou, Maria, additional, and Stefanis, Leonidas, additional

Published
2018
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