452 results on '"Berendt, Mette"'
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2. Biomarkers of non-infectious inflammatory CNS diseases in dogs: Where are we now? Part 2 — Steroid responsive meningitis-arteritis
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Andersen-Ranberg, Emilie, Berendt, Mette, and Gredal, Hanne
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- 2021
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3. Biomarkers of non-infectious inflammatory CNS diseases in dogs — Where are we now? Part I: Meningoencephalitis of unknown origin
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Andersen-Ranberg, Emilie, Berendt, Mette, and Gredal, Hanne
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- 2021
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4. Relationship between syringomyelia and myxomatous mitral valve disease in Cavalier King Charles spaniels
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Bach, Maiken B. T., Stougaard, Camilla L., Thøfner, Maria S., Reimann, Maria J., Westrup, Ulrik, Koch, Jørgen, Fredholm, Merete, Martinussen, Torben, Berendt, Mette, Olsen, Lisbeth H., Bach, Maiken B. T., Stougaard, Camilla L., Thøfner, Maria S., Reimann, Maria J., Westrup, Ulrik, Koch, Jørgen, Fredholm, Merete, Martinussen, Torben, Berendt, Mette, and Olsen, Lisbeth H.
- Abstract
Background Syringomyelia (SM) and myxomatous mitral valve disease (MMVD) are highly prevalent in Cavalier King Charles spaniels (CKCS). Cardiac status in CKCS with and without SM is currently unknown. Objectives To investigate the association between SM and MMVD severity in CKCS and CKCS with SM with and without clinical signs of SM. Animals Fifty-five CKCS: 40 with SM (22 symptomatic and 18 asymptomatic) and 15 without SM. Methods A combined retrospective and prospective study. MRI and echocardiography were used to diagnose SM and MMVD, respectively. The association between SM and MMVD severity (left ventricle internal diameter in diastole normalized to bodyweight [LVIDDN] and left atrium to aortic ratio [LA/Ao]) were tested using multivariable linear regression analysis adjusting for sex and age. Results Overall, no significant difference in LVIDDN and LA/Ao was found between CKCS with or without SM. However, CKCS with symptomatic SM had significantly smaller LVIDDN (1.45 [1.30-1.50]) (median [IQR]) and LA/Ao (1.20 [1.10-1.28]) compared to CKCS with asymptomatic SM (1.60 [1.50-1.90] and 1.40 [1.20-1.75]) as well as CKCS without SM (0.24 [0.03-0.45] and 0.30 [0.05-0.56]) (all P values <.03). Conclusions and Clinical Importance An association between MMVD and SM was not confirmed in this cohort of CKCS, indicating that MMVD and SM do not co-segregate. However, CKCS with symptomatic SM had smaller left ventricle and atrial size compared to CKCS with asymptomatic SM and CKCS without SM., BACKGROUND: Syringomyelia (SM) and myxomatous mitral valve disease (MMVD) are highly prevalent in Cavalier King Charles spaniels (CKCS). Cardiac status in CKCS with and without SM is currently unknown.OBJECTIVES: To investigate the association between SM and MMVD severity in CKCS and CKCS with SM with and without clinical signs of SM.ANIMALS: Fifty-five CKCS: 40 with SM (22 symptomatic and 18 asymptomatic) and 15 without SM.METHODS: A combined retrospective and prospective study. MRI and echocardiography were used to diagnose SM and MMVD, respectively. The association between SM and MMVD severity (left ventricle internal diameter in diastole normalized to bodyweight [LVIDDN] and left atrium to aortic ratio [LA/Ao]) were tested using multivariable linear regression analysis adjusting for sex and age.RESULTS: Overall, no significant difference in LVIDDN and LA/Ao was found between CKCS with or without SM. However, CKCS with symptomatic SM had significantly smaller LVIDDN (1.45 [1.30-1.50]) (median [IQR]) and LA/Ao (1.20 [1.10-1.28]) compared to CKCS with asymptomatic SM (1.60 [1.50-1.90] and 1.40 [1.20-1.75]) as well as CKCS without SM (0.24 [0.03-0.45] and 0.30 [0.05-0.56]) (all P values <.03).CONCLUSIONS AND CLINICAL IMPORTANCE: An association between MMVD and SM was not confirmed in this cohort of CKCS, indicating that MMVD and SM do not co-segregate. However, CKCS with symptomatic SM had smaller left ventricle and atrial size compared to CKCS with asymptomatic SM and CKCS without SM.
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- 2024
5. Dorsal horn volume loss and pain pathway changes in Cavalier King Charles Spaniels with syringomyelia, signs of pain, and phantom scratching
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Mortensen, Danny, Thoefner, Maria Soendergaard, Agerholm, Joergen Steen, Slumstrup, Lasse, Jensen, Troels Staehelin, Bjerrum, Ole Jannik, Berendt, Mette, and Nyengaard, Jens Randel
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- 2022
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6. Pregabalin alleviates clinical signs of syringomyelia-related central neuropathic pain in Cavalier King Charles Spaniel dogs: a randomized controlled trial
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Thoefner, Maria S., Skovgaard, Lene T., McEvoy, Fintan J., Berendt, Mette, and Bjerrum, Ole J.
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- 2020
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7. Canine induced pluripotent stem cells: an in vitro approach to validate the dog as a large animal model for Alzheimer’s disease
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de Figueiredo Pessôa, Laís Vicari, primary, Chandrasekaran, Abinaya, additional, Thomsen, Barbara Blicher, additional, Berendt, Mette, additional, Hyttel, Poul, additional, and Freude, Kristine, additional
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- 2021
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8. Contributors
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Berendt, Mette, primary, Bordignon, Vilceu, additional, Chandrasekaran, Abinaya, additional, Dardari, Rkia, additional, de Figueiredo Pessôa, Laís Vicari, additional, Dicks, Naomi, additional, Dinnyes, Andras, additional, Dobrinski, Ina, additional, Edenfield, Clayton, additional, Freude, Kristine, additional, Fukuda, Tomokazu, additional, Gladyshev, Vadim N., additional, Guest, Debbie, additional, Hornsby, Peter J., additional, Hyttel, Poul, additional, Jeyhoonabadi, Maryam Ahmadi, additional, Katayama, Masafumi, additional, Kumar, Dharmendra, additional, Kumar, Pradeep, additional, Lara, Nathalia de Lima e Martins, additional, Lee, Sang-Goo, additional, Liu, Jun, additional, Malaver-Ortega, Luis F., additional, Mastromonaco, Gabriela F., additional, Mikhalchenko, Aleksei E., additional, Phakdeedindan, Praopilas, additional, Selokar, Naresh L., additional, Siracusa, Jacob, additional, Sumer, Huseyin, additional, Tharasanit, Theerawat, additional, Thomsen, Barbara Blicher, additional, Verma, Paul J., additional, Wang, Ruoning, additional, West, Franklin D., additional, Yadav, P.S., additional, and Yu, Xiaozhong, additional
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- 2021
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9. Clinical characteristics, prognosis and quality of life in a cohort of dogs with disc disease treated conservatively or surgically
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Samsøe-Schmidt, Frederik, Miles, James Edward, Berendt, Mette, Samsøe-Schmidt, Frederik, Miles, James Edward, and Berendt, Mette
- Abstract
Objectives: Intervertebral disc disease (IVDD) is a common neurological condition in dogs. Information of prognosis and quality of life (QOL) is however limited. We aimed to investigate the outcome and QOL of dogs treated for IVDD. Methods: Retrospective case study of dogs with clinical signs of IVDD alongside a pre-planned structured QOL telephone follow-up owner interview, using closed- and open-ended questions. A modified Frankel score was used to compare disease severity between surgically and conservatively treated dogs. Data from follow-up interviews were analysed using Excel. Response categories were made to analyse open-ended questions. Results: 129 dogs were included in the study. Forty-two owners participated in follow-up interviews. Surgically treated dogs had significantly worse modified Frankel scores at initial presentation compared to conservatively treated dogs (p < 0.003). In both treatment groups, 50% of dogs experienced long-term deficiencies after IVDD treatment e.g difficulty jumping or reduced stamina. Twice as many dogs in the surgical group received physiotherapy as part of treatment. Almost all owners believed their dogs QOL was the same as before the disease. A majority of owners however, reported that IVDD in their dog caused them emotional distress, thus influencing their life negatively. Impact: Our results suggest that the prognosis of dogs treated for IVDD is good; however, owners should be informed that long-term sequelae are not uncommon. There is a need for more focus on how dogs’ IVDD affect their owners and guidelines on how to provide the most optimal owner support.
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- 2023
10. A comparison of 2 screening questionnaires for clinical assessment of canine cognitive dysfunction
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Schütt, Trine, Toft, Nils, and Berendt, Mette
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- 2015
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11. List of Contributors
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Abdel-Rahman, Emaad M., primary, Ackerman, Hayley D., additional, Akintola, Abimbola, additional, Amdam, Gro V., additional, Atzmon, Gil, additional, Austad, Steve, additional, Awate, Sanket, additional, Balaskó, Márta, additional, Banerjee, Taraswi, additional, Bárcena, Clea, additional, Bartke, Andrzej, additional, Bassi, Ivan, additional, Berendt, Mette, additional, Bijlsma, Maarten F., additional, Bitto, Alessandro, additional, Bizon, Jennifer L., additional, Bollaerts, Ilse, additional, Bonomi, Marco, additional, Borras, Consuelo, additional, Bowman, Brendan T., additional, Brioche, Thomas, additional, Brosh, Robert M., additional, Brown, Richard E., additional, Buck, Kerstin, additional, Burke, Sara N., additional, Buzgariu, Wanda, additional, Cacabelos, Ramón, additional, Camina Martín, M.A., additional, Chaffee, Beth K., additional, Chan, Anthony W.S., additional, Chen, Haolin, additional, Chen, Zhiguo, additional, Cho, In K., additional, Chopard, Angèle, additional, Cogger, Victoria C., additional, Cohen, Alan A., additional, Confino, Rafael, additional, Coppedè, Fabio, additional, Costa, Anthony J., additional, Crouch, Jack D., additional, Darcy, Justin, additional, De Groef, Lies, additional, de Mateo Silleras, B., additional, Deepa, Sathyaseelan S., additional, Devau, Gina, additional, Dhenain, Marc, additional, Dills, Chantelle, additional, Duffy, Megan F., additional, Duncan, Francesca E., additional, Dupuis, Gilles, additional, Eaton, Benjamin A., additional, Egan, Josephine M., additional, Ekundayo, Kazadi, additional, Emborg, Marina E., additional, Fischer, D. Luke, additional, Fontes, Pascaline, additional, Fortepiani, Maria Lourdes Alarcon, additional, Fortin, Carl, additional, Franzke, Bernhard, additional, Fülöp, Tamas, additional, Gabriel, Camelia, additional, Galliot, Brigitte, additional, Gambini, Juan, additional, Garneau, Hugo, additional, Gasparini, Laura, additional, Gerhard, Glenn S., additional, Gibson, David C., additional, Gimeno-Mallench, Lucia, additional, Girard, Victor, additional, Greer, Kimberly A., additional, Gribble, Kristin E., additional, Gubbels Bupp, Melanie R., additional, Gudmundsson, Adalsteinn, additional, Hamann, Andrea, additional, Hamblin, Michael R., additional, Harper, James M., additional, Hart, Ronald, additional, Head, Elizabeth, additional, Herd, Heather R., additional, Herrera, Guadalupe, additional, Hisama, Fuki M., additional, Hogan, David B., additional, Holmes, Donna J., additional, Hornsby, Peter J., additional, Howlett, Susan E., additional, Hui, Ka Yi, additional, Jahn, Thomas R., additional, Jávega, Beatriz, additional, Jeffery, William R., additional, Johnson, Sarah A., additional, Jones, Audrey, additional, Jones, Corinne A., additional, Jónsson, Pálmi V., additional, Kane, Alice E., additional, Karasik, David, additional, Kean, Samuel, additional, Keller, Evan T., additional, Keller, Jill M., additional, Kemp, Christopher J., additional, Wong, Ken S.K., additional, Krøll, Jens, additional, Kumar Bharti, Sanjay, additional, Kurkinen, Markku, additional, Larbi, Anis, additional, Lasbleiz, Christelle, additional, Lautier, Corinne, additional, Le Couteur, David G., additional, Le Page, Aurelie, additional, Lin, Hang, additional, López-Otín, Carlos, additional, Lottonen-Raikaslehto, Line, additional, Magden, Elizabeth R., additional, Makrantonaki, Evgenia, additional, Manfredsson, Fredric P., additional, Mark Welch, David B., additional, Marques-Lopes, Jose, additional, Martínez-Romero, Alicia, additional, Mas-Bargues, Cristina, additional, Mayoral, Pablo, additional, Mc Auley, Mark, additional, McQuail, Joseph A., additional, Merentie, Mari, additional, Mestre-Frances, Nadine, additional, Metzger, Jeanette M., additional, Meyer, Keith C., additional, Milner, Teresa A., additional, Mizutani, Claudia M., additional, Monnat, Raymond J., additional, Mooney, Kathleen, additional, Moons, Lieve, additional, Muck, Joscha, additional, Muniyappa, Ranganath, additional, Nehlin, Jan O., additional, Neubauer, Oliver, additional, Nikolakis, Georgios, additional, Nyman, Jeffry S., additional, O’Connor, José-Enrique, additional, Oshima, Junko, additional, Osiewacz, Heinz D., additional, Papadopoulos, Vassilios, additional, Pavone, Mary Ellen, additional, Pawelec, Graham, additional, Pedersen, Jan T., additional, Perez-Lopez, Gonzalo, additional, Persani, Luca, additional, Pétervári, Erika, additional, Peyman, Azadeh, additional, Plate, Johannes F., additional, Polinski, Nicole K., additional, Py, Guillaume, additional, Quigley, Tyler P., additional, Rae, Eric A., additional, Ram, Jeffrey L., additional, Raubenheimer, David, additional, Reckelhoff, Jane F., additional, Redondo del Río, M.P., additional, Rex-Al Panem Orbon, Jovy, additional, Richardson, Arlan, additional, Ripperger, Jürgen A., additional, Rostás, Ildikó, additional, Rouse, Michael, additional, Rueppell, Olav, additional, Runge, Kurt W., additional, Safdar, Maryam, additional, Sankaran-Walters, Sumathi, additional, Santago, Anthony C., additional, Sarvimäki, Anneli, additional, Saul, Katherine R., additional, Schenkelaars, Quentin, additional, Schneider, Brandt L., additional, Schütt, Trine, additional, Shen, He, additional, Shin, Sooyoun, additional, Simpson, Stephen J., additional, Smith, Jessica, additional, Snell, Terry W., additional, Snyder, Jessica M., additional, Solon-Biet, Samantha M., additional, Soós, Szilvia, additional, Sortwell, Caryl E., additional, Sousa-Neves, Rui, additional, Steece-Collier, Kathy, additional, Steins, Anne, additional, Sujkowski, Alyson, additional, Swanberg, Susan E., additional, Teijido, Oscar, additional, Tella, Sri Harsha, additional, Tenk, Judit, additional, Tomczyk, Szymon, additional, Treuting, Piper M., additional, Trouche, Stéphanie G., additional, Tuan, Rocky S., additional, Unnikrishnan, Archana, additional, Valenzano, Dario Riccardo, additional, van Heemst, Diana, additional, Van houcke, Jessie, additional, Van Kempen, Tracey A., additional, van Laarhoven, Hanneke W.M., additional, Verdier, Jean-Michel, additional, Viña, Jose, additional, Wagner, Karl-Heinz, additional, Wahl, Devin, additional, Wenger, Yvan, additional, Wessells, Robert J., additional, Wilcock, Donna M., additional, Witkowski, Jacek M., additional, Wong, Esther, additional, Woodland, Nicole, additional, Yanes Cardozo, Licy L., additional, Ylä-Herttuala, Seppo, additional, Youssef, Sameh A., additional, Yuan, Rong, additional, Zhang, Haitao, additional, Zhou, Zhongjun, additional, Zirkin, Barry R., additional, and Zouboulis, Christos C., additional
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- 2018
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12. The Domestic Dog as a Model for Human Brain Aging and Alzheimer’s Disease
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Schütt, Trine, primary, Pedersen, Jan T., additional, and Berendt, Mette, additional
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- 2018
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13. Collection of cerebrospinal fluid into EDTA versus plain tubes does not affect the standard analysis in dogs
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Koch, Bodil Cathrine, Daniels, Lea Ophelia, Thomsen, Line Tang, Nielsen, Michelle Brønniche Møller, Berendt, Mette, and Gredal, Hanne
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- 2019
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14. Validation of the diagnosis canine epilepsy in a Swedish animal insurance database against practice records
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Heske, Linda, Berendt, Mette, Jäderlund, Karin Hultin, Egenvall, Agneta, and Nødtvedt, Ane
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- 2014
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15. Clinical Characteristics, Prognosis and Quality of Life in a Cohort of Dogs with Disc Disease Treated Conservatively or Surgically
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Berendt, Mette, Miles, James Edward, Samsøe-Schmidt, Frederik, Berendt, Mette, Miles, James Edward, and Samsøe-Schmidt, Frederik
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- 2022
16. Interleukin-6 is increased in plasma and cerebrospinal fluid of community-dwelling domestic dogs with acute ischaemic stroke
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Gredal, Hanne, Thomsen, Barbara B., Boza-Serrano, Antonio, Garosi, Laurent, Rusbridge, Clare, Anthony, Daniel, Møller, Arne, Finsen, Bente, Deierborg, Tomas, Lambertsen, Kate L., and Berendt, Mette
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- 2017
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17. Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog
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Chandrasekaran, Abinaya, primary, Thomsen, Barbara Blicher, additional, Agerholm, Jørgen Steen, additional, Pessôa, Laís Vicari de Figueiredo, additional, Godoy Pieri, Naira Caroline, additional, Sabaghidarmiyan, Vahideh, additional, Langley, Katarina, additional, Kolko, Miriam, additional, de Andrade, André Furugen Cesar, additional, Bressan, Fabiana Fernandes, additional, Hyttel, Poul, additional, Berendt, Mette, additional, and Freude, Kristine, additional
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- 2021
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18. Mild Microglial Responses in the Cortex and Perivascular Macrophage Infiltration in Subcortical White Matter in Dogs with Age-Related Dementia Modelling Prodromal Alzheimer’s Disease
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Thomsen, Barbara Blicher, primary, Madsen, Cecilie, additional, Krohn, Katrine Tækker, additional, Thygesen, Camilla, additional, Schütt, Trine, additional, Metaxas, Athanasios, additional, Darvesh, Sultan, additional, Agerholm, Jørgen Steen, additional, Wirenfeldt, Martin, additional, Berendt, Mette, additional, and Finsen, Bente, additional
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- 2021
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19. Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D
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Skedsmo, Fredrik S., Espenes, Arild, Tranulis, Michael A., Matiasek, Kaspar, Gunnes, Gjermund, Bjerkås, Inge, Moe, Lars, Skogtvedt Røed, Susan, Berendt, Mette, Fredholm, Merete, Rohdin, Cecilia, Shelton, G. Diane, Bruheim, Per, Stafsnes, Marit H., Bartosova, Zdenka, Stigen, Øyvind, and Jäderlund, Karin H.
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Clinical Science - Abstract
Mutations in the N-myc downstream-regulated gene 1 (NDRG1) cause degenerative polyneuropathy in ways that are poorly understood. We have investigated Alaskan Malamute dogs with neuropathy caused by a missense mutation in NDRG1. In affected animals, nerve levels of NDRG1 protein were reduced by more than 70% (p < 0.03). Nerve fibers were thinly myelinated, loss of large myelinated fibers was pronounced and teased fiber preparations showed both demyelination and remyelination. Inclusions of filamentous material containing actin were present in adaxonal Schwann cell cytoplasm and Schmidt-Lanterman clefts. This condition strongly resembles the human Charcot-MarieTooth type 4D. However, the focally folded myelin with adaxonal infoldings segregating the axon found in this study are ultrastructural changes not described in the human disease. Furthermore, lipidomic analysis revealed a profound loss of peripheral nerve lipids. Our data suggest that the low levels of mutant NDRG1 is insufficient to support Schwann cells in maintaining myelin homeostasis. (C) 2020 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license.
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- 2021
20. Mild Microglial Responses in the Cortex and Perivascular Macrophage Infiltration in Subcortical White Matter in Dogs with Age-Related Dementia Modelling Prodromal Alzheimer's Disease
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Thomsen, Barbara Blicher, Madsen, Cecilie, Krohn, Katrine Tækker, Thygesen, Camilla, Schütt, Trine, Metaxas, Athanasios, Darvesh, Sultan, Agerholm, Jørgen Steen, Wirenfeldt, Martin, Berendt, Mette, Finsen, Bente, Thomsen, Barbara Blicher, Madsen, Cecilie, Krohn, Katrine Tækker, Thygesen, Camilla, Schütt, Trine, Metaxas, Athanasios, Darvesh, Sultan, Agerholm, Jørgen Steen, Wirenfeldt, Martin, Berendt, Mette, and Finsen, Bente
- Abstract
Background: Microglia contribute to Alzheimer's disease (AD) pathogenesis by clearing amyloid-β (Aβ) and driving neuroinflammation. Domestic dogs with age-related dementia (canine cognitive dysfunction (CCD)) develop cerebral amyloidosis like humans developing AD, and studying such dogs can provide novel information about microglial response in prodromal AD. Objective: The aim was to investigate the microglial response in the cortical grey and the subcortical white matter in dogs with CCD versus age-matched cognitively normal dogs. Methods: Brains from aged dogs with CCD and age-matched controls without dementia were studied. Cases were defined by dementia rating score. Brain sections were stained for Aβ, thioflavin S, hyperphosphorylated tau, and the microglial-macrophage ionized calcium binding adaptor molecule 1 (Iba1). Results were correlated to dementia rating score and tissue levels of Aβ. Results: Microglial numbers were higher in the Aβ plaque-loaded deep cortical layers in CCD versus control dogs, while the coverage by microglial processes were comparable. Aβ plaques were of the diffuse type and without microglial aggregation. However, a correlation was found between the %Iba1 area and insoluble Aβ 42 and N-terminal pyroglutamate modified Aβ(N3pE)-42. The %Iba1 area was higher in white matter, showing phosphorylation of S396 tau, versus grey matter. Perivascular macrophage infiltrates were abundant in the white matter particularly in CDD dogs. Conclusion: The results from this study of the microglial-macrophage response in dogs with CCD are suggestive of relatively mild microglial responses in the Aβ plaque-loaded deep cortical layers and perivascular macrophage infiltrates in the subcortical white matter, in prodromal AD.
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- 2021
21. Biomarkers of non-infectious inflammatory CNS diseases in dogs:Where are we now? Part 2 — Steroid responsive meningitis-arteritis
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Andersen-Ranberg, Emilie, Berendt, Mette, Gredal, Hanne, Andersen-Ranberg, Emilie, Berendt, Mette, and Gredal, Hanne
- Abstract
Steroid responsive meningitis-arteritis (SRMA) in dogs causes severe inflammation of meningeal arteries leading to generalized meningitis with possible neurological signs, as well as a systemic inflammatory response. The etiology and exact pathogenesis are unknown, but an immune-mediated origin has been suggested and is supported by a positive response to immunosuppressive treatment with corticosteroids. A collection of clinical and paraclinical characteristics may be highly indicative of SRMA, but a single and conclusive diagnostic test or biomarker is currently not available. The aim of this review is to provide an overview of the current understanding and knowledge on SRMA, with special emphasis on potential biomarkers and their applicability in the diagnostic work-up. Though no specific markers for SRMA currently exist, clinically useful markers include IgA and several acute phase proteins e.g. C-reactive protein. A frequent problem of both acknowledged and proposed biomarkers, is, however, their inability to effectively differentiate SRMA from other systemic inflammatory conditions. Other proposed diagnostic markers include genetic markers, acute phase proteins such as serum amyloid A, cytokines such as interleukin-17 and CC-motif ligand 19, endocannabinoid receptors and heat shock protein 70; these suggestions however either lack specificity or need further investigation.
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- 2021
22. Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog
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Chandrasekaran, Abinaya, Thomsen, Barbara Blicher, Agerholm, Jørgen Steen, Pessôa, Laís Vicari De Figueiredo, Godoy Pieri, Naira Caroline, Sabaghidarmiyan, Vahideh, Langley, Katarina, Kolko, Miriam, De Andrade, André Furugen Cesar, Bressan, Fabiana Fernandes, Hyttel, Poul, Berendt, Mette, Freude, Kristine, Chandrasekaran, Abinaya, Thomsen, Barbara Blicher, Agerholm, Jørgen Steen, Pessôa, Laís Vicari De Figueiredo, Godoy Pieri, Naira Caroline, Sabaghidarmiyan, Vahideh, Langley, Katarina, Kolko, Miriam, De Andrade, André Furugen Cesar, Bressan, Fabiana Fernandes, Hyttel, Poul, Berendt, Mette, and Freude, Kristine
- Abstract
Domestic dogs are superior models for translational medicine due to greater anatomical and physiological similarities with humans than rodents, including hereditary diseases with human equivalents. Particularly with respect to neurodegenerative medicine, dogs can serve as a natural, more relevant model of human disease compared to transgenic rodents. Herein we report attempts to develop a canine-derived in vitro model for neurodegenerative diseases through the generation of induced pluripotent stem cells from a 14-year, 9-month-old female West Highland white terrier with mild cognitive impairment (MCI). Canine induced pluripotent stem cells-like cells (ciPSCLC) were generated using human OSKM and characterized by positive expression of pluripotency markers. Due to inefficient viral vector silencing we refer to them as ciPSCLCs. Subsequently, the ciPSCLC were subjected to neural induction according to two protocols both yielding canine neural progenitor cells (cNPCs), which expressed typical NPC markers. The cNPCs were cultured in neuron differentiation media for 3 weeks, resulting in the derivation of morphologically impaired neurons as compared to iPSC-derived human counterparts generated in parallel. The apparent differences encountered in this study regarding the neural differentiation potential of ciPSCLC reveals challenges and new perspectives to consider before using the canine model in translational neurological studies.
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- 2021
23. Evaluation of the impact of using a simulator for teaching veterinary students cerebrospinal fluid collection:A mixed-methods study
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Langebæk, Rikke, Berendt, Mette, Tipold, Andrea, Engelskirchen, Simon, Dilly, Marc, Langebæk, Rikke, Berendt, Mette, Tipold, Andrea, Engelskirchen, Simon, and Dilly, Marc
- Abstract
The collection of cerebrospinal fluid (CSF) plays a pivotal role in the diagnosis of central nervous system diseases. Prior training in this invasive procedure is essential to minimize the risk of harming animals. Because of this risk, stress and anxiety can influence the learning process. Simulators can be used to teach and learn invasive procedures.The aim of this mixed-methods study was to validate a CSF collection simulator and investigate students' perceptions of the simulator as an educational tool.The quantitative approach validated the simulator for face and content validity, and students provided a general evaluation of the simulator using surveys.The simulator's construct validity was measured by means of a global rating scale. Students' perceptions were investigated qualitatively using semi-structured interviews. Experts (n = 13) confirmed the simulator's face and content validity. Students (n = 16) evaluated the simulator as supportive of their learning. Results for construct validity demonstrated higher global rating scores from experts than from students. The scores for procedural performance and procedural knowledge and flow showed significant differences (p ≤.05).Analysis of interviews with students (n = 10) revealed four main themes: emotions, learning process, evaluation of the model, and CSF collection procedure. In conclusion, this study validated the use of the CSF simulator as an educational tool that can help students overcome some of their anxiety in relation to performing an invasive procedure.
- Published
- 2021
24. Evaluation of the Impact of Using a Simulator for Teaching Veterinary Students Cerebrospinal Fluid Collection: A Mixed-Methods Study
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Langebæk, Rikke, primary, Berendt, Mette, additional, Tipold, Andrea, additional, Engelskirchen, Simon, additional, and Dilly, Marc, additional
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- 2021
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25. Pregabalin alleviates clinical signs of syringomyelia-related central neuropathic pain in Cavalier King Charles Spaniel dogs:a randomized controlled trial
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Thoefner, Maria S., Skovgaard, Lene T., McEvoy, Fintan J., Berendt, Mette, Bjerrum, Ole J., Thoefner, Maria S., Skovgaard, Lene T., McEvoy, Fintan J., Berendt, Mette, and Bjerrum, Ole J.
- Abstract
Objective: We aimed to assess the efficacy and benefit-risk profile of pregabalin (PGN) to reduce the clinical signs of central neuropathic pain (CNeP) as reflected by scratching episodes in dogs with symptomatic syringomyelia (SM). Study design: Randomized, double-blind, placebo-controlled crossover study. Animals: A total of 12 client-owned Cavalier King Charles Spaniels (age, 1.1–7.4 years, bodyweight, 8.2–10.8 kg) with magnetic resonance imaging-confirmed SM and clinical signs of CNeP. Methods: Dogs were randomized to either PGN 150 mg or placebo for 25 days, followed by 48 hour washout period before crossover to the alternate phase of 25 days. The primary outcome was defined as number of scratching events during 10 minutes of video-recorded physical activity. Treatment effect was estimated using a generalized estimation equation model. Benefit-risk and quality of life assessments were obtained through owner interviews focusing on potential adverse events. Results: The treatment effect estimate was an 84% (95% confidence interval = 75–89%) reduction in mean number of scratching events relative to baseline compared with placebo (p < 0.0001). Owner-assessed satisfactory quality of life was status quo and rated as ‘good’ or ‘could not be better’ in six/11 dogs and improved in four/11 dogs. The most prevalent adverse events were increased appetite in nine/12 dogs and transient ataxia in nine/12 dogs. There was one dog withdrawn by the owner 7 days after crossover to PGN owing to persistent ataxia. No dogs needed rescue analgesia during the trial. Conclusions and clinical relevance: PGN is superior to placebo in the reduction of clinical signs of SM-related CNeP in dogs. At a dose range of 13–19 mg kg–1 orally twice daily, the encountered adverse events were acceptable to all but one owner.
- Published
- 2020
26. Canine induced pluripotent stem cells:An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease
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De Figueiredo Pessôa, Laís Vicari, Chandrasekaran, Abinaya, Thomsen, Barbara Blicher, Berendt, Mette, Hyttel, Poul, Freude, Kristine, De Figueiredo Pessôa, Laís Vicari, Chandrasekaran, Abinaya, Thomsen, Barbara Blicher, Berendt, Mette, Hyttel, Poul, and Freude, Kristine
- Abstract
Canine cognitive dysfunction (CCD) is a potential natural model for human Alzheimer’s disease (AD). In this chapter we are addressing the current procedures of how to obtain canine induced pluripotent stem cells (ciPSCs) from geriatric dogs and the available protocols for differentiation of ciPSC into neurons. Moreover, we present how these neurons derived from ciPSC can be compared to human iPSC (hiPSC)-derived neurons in order to validate dogs with CCD as natural models for AD. This practical example presents the importance to generate species-specific iPSC to broaden our knowledge of cell type-specific disease models and to investigate, compare, and evaluate the different animal models as appropriate disease models for human diseases.
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- 2020
27. Canine induced pluripotent stem cells:an in vitro approach to validate the dog as a large animal model for Alzheimer's disease
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Pessoa, Lai's Vicari de Figueiredo, Chandrasekaran, Abinaya, Thomsen, Barbara Blicher, Berendt, Mette, Hyttel, Poul, Freude, Kristine, Pessoa, Lai's Vicari de Figueiredo, Chandrasekaran, Abinaya, Thomsen, Barbara Blicher, Berendt, Mette, Hyttel, Poul, and Freude, Kristine
- Published
- 2020
28. Using Creativity as an Educational Tool in Veterinary Surgery:Students' Perceptions and Surgical Performance
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Langebæk, Rikke, Tanggaard, Lene, Toft, Nils, Berendt, Mette, Langebæk, Rikke, Tanggaard, Lene, Toft, Nils, and Berendt, Mette
- Abstract
With the aim of improving students' ability to handle the complexity of surgery, we introduced a creative assignment in a veterinary surgical course. We hypothesized that by using this active, inductive educational method, reflection, creativity and self-efficacy in student novice surgeons could be improved. During a companion animal surgical course an intervention group was investigated against a control group. Twenty-nine fourth-year students were instructed in ovariohysterectomy by classical lectures, while 23 fourth-year students were provided with creative materials and assigned to consider and illustrate how to perform the procedure themselves. Surgical performance was assessed for both groups using a modified Objective Structured Assessment of Technical Skills (OSATS) while performing a simulated ovariohysterectomy. Furthermore, both groups were investigated with respect to how they would handle a specific hypothetical surgical complication. Semi-structured interviews were conducted with 17 intervention-group students and were analyzed using thematic analysis. The intervention group showed a significantly better performance and needed significantly less help with the surgical complication than the control group students. Data from interviews furthermore demonstrated that students believed the creative intervention produced increased reflection, more creative initiatives, and a feeling of security before surgery. Our study results thus indicate that an educational tool which stimulates creative thinking can promote reflection, creativity, and self-efficacy in novice surgeons without compromising surgical performance.
- Published
- 2020
29. Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D
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Skedsmo, Fredrik S., primary, Espenes, Arild, additional, Tranulis, Michael A., additional, Matiasek, Kaspar, additional, Gunnes, Gjermund, additional, Bjerkås, Inge, additional, Moe, Lars, additional, Røed, Susan Skogtvedt, additional, Berendt, Mette, additional, Fredholm, Merete, additional, Rohdin, Cecilia, additional, Shelton, G. Diane, additional, Bruheim, Per, additional, Stafsnes, Marit H., additional, Bartosova, Zdenka, additional, Hermansen, Lene C., additional, Stigen, Øyvind, additional, and Jäderlund, Karin H., additional
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- 2021
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30. Using Creativity as an Educational Tool in Veterinary Surgery: Students’ Perceptions and Surgical Performance
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Langebæk, Rikke, primary, Tanggaard, Lene, additional, Toft, Nils, additional, and Berendt, Mette, additional
- Published
- 2020
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31. Re-emergence of hereditary polyneuropathy in Scandinavian Alaskan malamute dogs—old enemy or new entity? A case series
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Jäderlund, Karin Hultin, Rohdin, Cecilia, Berendt, Mette, Stigen, Øyvind, Fredholm, Merete, Espenes, Arild, Bjerkås, Inge, and Moe, Lars
- Subjects
Inherited ,lcsh:Veterinary medicine ,Intracellular Signaling Peptides and Proteins ,Cell Cycle Proteins ,NDRG1-gene ,Brief Communication ,Pedigree ,Polyneuropathies ,Dogs ,Gene Expression Regulation ,Polyneuropathy ,Mutation ,Dog ,Animals ,Recessive ,lcsh:SF600-1100 ,Genetic Predisposition to Disease ,Dog Diseases - Abstract
A homozygous mutation has been identified in the N-myc downstream-regulated gene 1 (NDRG1) in recent cases of polyneuropathy in Alaskan malamute dogs from the Nordic countries and USA. The objective of the present study was to determine if cases diagnosed 30–40 years ago with polyneuropathy in the Alaskan malamute breed in Norway had the same hereditary disease as the recent cases. Fourteen historical cases and 12 recently diagnosed Alaskan malamute dogs with hereditary polyneuropathy, and their parents and littermates (n = 88) were included in this study (total n = 114). After phenotyping of historical and recent cases, NDRG1 genotyping was performed using DNA extracted from archived material from five Norwegian dogs affected by the disease in the late 1970s and 1980s. In addition, pedigrees were analysed. Our study concluded that historical and recent phenotypic polyneuropathy cases were carrying the same NDRG1-mutation. The pedigree analysis showed that all affected Alaskan malamute cases with polyneuropathy could be traced back to one common ancestor of North American origin. By this study, a well-documented example of the silent transmission of recessive disease-causing alleles through many generations is provided, demonstrated by the re-emergence of a phenotypically and genetically uniform entity in the Scandinavian Alaskan malamute population.
- Published
- 2017
32. D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
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Koch, Bodil Cathrine, Motta, Luca, Wiinberg, Bo, Westrup, Ulrik, Kristensen, Annemarie Thuri, Skerritt, Geoff, Berendt, Mette, Gredal, Hanne, Koch, Bodil Cathrine, Motta, Luca, Wiinberg, Bo, Westrup, Ulrik, Kristensen, Annemarie Thuri, Skerritt, Geoff, Berendt, Mette, and Gredal, Hanne
- Abstract
Ischemic stroke is a condition increasingly recognized in dogs; however, the number of publications on dogs with ischemic stroke is still limited and hemostatic parameters are infrequently reported. D-dimer levels have been shown to be elevated in people with acute ischemic stroke compared to a healthy control population and it has been proposed that a normal D-dimer can be used to exclude thromboembolism in dogs. In this case series, we report hemostatic parameters, including D-dimer and thromboelastography (TEG) along with clinical and imaging findings for five dogs diagnosed with ischemic stroke. All dogs had a normal D-dimer concentration on presentation. A hypercoagulable state was identified in two dogs based on the results of the TEG, and was suspected in the remaining three cases based on a shortened TEG clot reaction time. Based on the findings in the present cases, a D-dimer within the normal reference range does not seem an appropriate negative predictor for canine ischemic stroke. The demonstration of a possible hypercoagulable state, as identified by the TEG, is an interesting finding which should be explored further to help reveal predisposing hypercoagulable conditions in dogs with ischemic stroke.
- Published
- 2019
33. Chapter 15 - The Domestic Dog as a Model for Human Brain Aging and Alzheimer’s Disease
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Schütt, Trine, Pedersen, Jan T., and Berendt, Mette
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- 2018
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34. D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
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Koch, Bodil Cathrine, primary, Motta, Luca, additional, Wiinberg, Bo, additional, Westrup, Ulrik, additional, Kristensen, Annemarie Thuri, additional, Skerritt, Geoff, additional, Berendt, Mette, additional, and Gredal, Hanne, additional
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- 2019
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35. Acute neurological signs as the predominant clinical manifestation in four dogs with Angiostrongylus vasorum infections in Denmark
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Pors Susanne E, Kirk Rikke K, Koch Jørgen, Kristensen Annemarie T, Nielsen Ole L, Jensen Henrik E, Willesen Jakob L, Gredal Hanne, Skerritt Geoff C, and Berendt Mette
- Subjects
Veterinary medicine ,SF600-1100 - Abstract
Abstract Four dogs with acute neurological signs caused by haemorrhages in the central nervous system were diagnosed with Angiostrongylus vasorum infection as the underlying aetiology. Two dogs presented with brain lesions, one dog with spinal cord lesions and one with lesions in both the brain and spinal cord. Only one dog presented with concurrent signs of classical pulmonary angiostrongylosis (respiratory distress, cough), and only two dogs displayed overt clinical signs of haemorrhages. Results of coagulation assays were inconsistent. Neurological signs reflected the site of pathology and included seizures, various cranial nerve deficits, vestibular signs, proprioceptive deficits, ataxia and paraplegia. One dog died and three were euthanised due to lack of improvement despite medical treatment. This emphasises canine angiostrongylosis as a potential cause of fatal lesions of the central nervous system and the importance of including A. vasorum as a differential diagnosis in young dogs with acute neurological signs in Denmark.
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- 2011
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36. Prevalence of tick-borne encephalitis virus antibodies in dogs from Denmark
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Houser Geoffrey A, Jensen Per M, Meldgaard Danny S, Lindhe Katherine ES, and Berendt Mette
- Subjects
Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Large regions of central and eastern Europe are recognized as areas where tick-borne encephalitis virus (TBEV) is endemic, including countries neighbouring Denmark. It is therefore timely and relevant to determine if TBEV infections occur in Denmark. This study investigates the presence of antibodies against TBEV in a cross-section of the Danish canine population to assess the level of exposure to TBEV and possibly identify TBEV microfoci in Denmark. Methods Blood samples were collected from 125 dogs originating from five regions of Denmark between November 2005 and March 2006. Serum was tested by indirect ELISA. All positive and borderline samples were re-evaluated by neutralisation test (NT). Results The prevalence of TBEV serocomplex antibodies was 30% by ELISA and 4.8% by NT (with 100%-neutralising capacity). The island of Bornholm was the only area in Denmark with NT positive samples. Conclusions The island of Bornholm is an area with a high risk of encountering TBEV microfoci. The presence of TBEV serocomplex antibodies in many sentinel animals from other parts of Denmark points toward existence of other TBEV microfoci. Discrepancies found between ELISA and NT results stress the importance of careful evaluation of serological tests, when interpreting results.
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- 2009
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37. Prevalence and characteristics of epilepsy in the Belgian shepherd variants Groenendael and Tervueren born in Denmark 1995–2004
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Fredholm Merete, Gredal Hanne, Gudmundsdottir Hulda, Christensen Stine, Gulløv Christina, Berendt Mette, and Alban Lis
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Veterinary medicine ,SF600-1100 - Abstract
Abstract Background The Belgian shepherd Groenendael and Tervueren is believed to be at higher risk of developing epilepsy than dogs of the common population. This epidemiological study was designed to estimate the prevalence of epilepsy in the Danish population of Groenendael and Tervueren born between 1995 and 2004. Furthermore, it was the intention to describe the clinical manifestation (seizure types and phenomenology) of epilepsy and to identify risk factors for euthanasia once the dog was diagnosed as having epilepsy. Methods All owners of Groenendael and Tervueren dogs born between January 1995 and December 2004 and registered in the Danish Kennel Club (1,248 dogs) were contacted and asked to answer a mailed questionnaire concerning epilepsy. Positive responders were subsequently validated in a follow-up interview conducted by telephone using a standardized questionnaire. Owners were questioned about age at first seizure, seizure frequency, seizure duration, a detailed description of seizure phenomenology, post-ictal signs and if a veterinarian had diagnosed the dog with epilepsy. Results Prevalence of epilepsy was estimated at 9.5%. Mean age of epilepsy debut was 3.3 years (range 0.5–8.0 years). There was an almost equal number of Groenendael (25) and Tervueren (24). The distribution of females and males was 31 and 18 respectively. Twenty-five per cent experienced focal seizures, 53% experienced focal seizures with secondary generalization and 18% experienced primary generalized seizures. In four percent seizures were unclassifiable. The most commonly reported focal seizure phenomenology included ataxia, crawling, swaying, fearful behavior, salivation, excessive attention seeking and disorientation. In 16% of the cases, epilepsy led to euthanasia. Intact dogs with epilepsy had a significantly increased risk of being euthanized because of epilepsy compared to neutered dogs with epilepsy. In 22% of the cases the owners reported that anxiety/hyperactivity/stress could act as a seizure provoking factor. Conclusion A high prevalence of epilepsy appears to be present in the Danish Groenendael and Tervueren population. The relatively late debut age of epilepsy in this breed contributes greatly to the increased prevalence of epileptic individuals, because dogs developing epilepsy late in life are used for breeding unintended.
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- 2008
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38. Effect of skull type on the relative size of cerebral cortex and lateral ventricles in dogs
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Pilegaard, Anders M., Berendt, Mette, Holst, Pernille, Møller, Arne, McEvoy, Fintan J., Pilegaard, Anders M., Berendt, Mette, Holst, Pernille, Møller, Arne, and McEvoy, Fintan J.
- Abstract
Volume measurements of the brain are of interest in the diagnosis of brain pathology. This is particularly so in the investigation hydrocephalus and canine cognitive dysfunction (CCD), both of which result in thinning of the cerebral cortex and enlarged ventricles. Volume assessment can be made using computed tomography or more usually magnetic resonance imaging (MRI). There is, however, some uncertainty in the interpretation of such volume data due to the great variation in skull size and shape seen in dog. In this retrospective study, we examined normal MRI images from 63 dogs < 6 years of age. We used a continuous variable, the cranial index (CrI) to indicate skull shape and compared it with MRI volume measurements derived using Cavalieri's principle. We found a negative correlation between CrI and the ratio of cortical to ventricular volume. Breeds with a high CrI (large laterolateral compared to rostrocaudal cranial cavity dimension) had a smaller ratio of cortical to ventricular volume (low C:V ratio) than breeds with lower CrI skull types. It is important to consider this effect of skull shape on the relative volume estimates of the cerebral cortex and ventricles when trying to establish if pathology is present.
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- 2017
39. Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke
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Thomsen, Barbara Blicher, Gredal, Hanne, Wirenfeldt, Martin, Kristensen, Bjarne Winther, Clausen, Bettina Hjelm, Larsen, Anders Elm, Finsen, Bente, Berendt, Mette, Lambertsen, Kate Lykke, Thomsen, Barbara Blicher, Gredal, Hanne, Wirenfeldt, Martin, Kristensen, Bjarne Winther, Clausen, Bettina Hjelm, Larsen, Anders Elm, Finsen, Bente, Berendt, Mette, and Lambertsen, Kate Lykke
- Abstract
Background Dogs develop spontaneous ischaemic stroke with a clinical picture closely resembling human ischaemic stroke patients. Animal stroke models have been developed, but it has proved difficult to translate results obtained from such models into successful therapeutic strategies in human stroke patients. In order to face this apparent translational gap within stroke research, dogs with ischaemic stroke constitute an opportunity to study the neuropathology of ischaemic stroke in an animal species. Case presentation A 7 years and 8 months old female neutered Rottweiler dog suffered a middle cerebral artery infarct and was euthanized 3 days after onset of neurological signs. The brain was subjected to histopathology and immunohistochemistry. Neuropathological changes were characterised by a pan-necrotic infarct surrounded by peri-infarct injured neurons and reactive microglia/macrophages and astrocytes. Conclusions The neuropathological changes reported in the present study were similar to findings in human patients with ischaemic stroke. The dog with spontaneous ischaemic stroke is of interest as a complementary spontaneous animal model for further neuropathological studies.
- Published
- 2017
40. Epilepsie aktuell - Zusammenfassung der IVETF-Empfehlungen zum 'Therapeutischen Management der kaninen Epilepsie in Europa'
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Bhatti, Sofie, De Risio, Luisa, Muñana, Karen, Penderis, Jacques, Stein, Veronika M, Tipold, Andrea, Berendt, Mette, Farquhar, Robyn, Fischer, Andrea, Long, Sam, Löscher, Wolfgang, Mandigers, P.J.J., Matiasek, Kaspar, Pakozdy, Akos, Patterson, Ned, Platt, Simon, Podell, Michael, Potschka, Heidrun, Rusbridge, Clare, Volk, Holger A, Sub Neurologie, dIRAS RA-2, and dIRAS RA-I&I RA
- Subjects
Antiepileptika ,Hund ,epileptischer Anfall ,Epilepsie - Abstract
Das therapeutische Management der kaninen Epilepsie muss an die individuellen Bedürfnisse des Hundes und seines Besitzers angepasst werden. 2015 hat die International Veterinary Epilepsy Task Force (IVETF) die Konsensempfehlungen „Therapeutisches Management der kaninen Epilepsie in Europa“ veröffentlicht. In diesen Empfehlungen wird eine systematische therapeutische Vorgehensweise bei Hunden mit idiopathischer oder struktureller Epilepsie vorgeschlagen. Das Konsenspapier gibt außerdem einen Überblick über die in Europa zur Anwendung beim Hund zugelassenen Antiepileptika (AE) und empfiehlt Protokolle für die Arzneimitteltherapie. Der Konsensvorschlag basiert auf der aktuellen evidenzbasierten Literatur, berücksichtigt die aktuellen gesetzlichen Rahmenbedingungen in Europa und gibt die Erfahrungen der Autoren wieder. Im vorliegenden Artikel wird der Inhalt der Konsensusempfehlungen in deutscher Sprache zusammengefasst.
- Published
- 2016
41. Epilepsie aktuell - Zusammenfassung des Konsens papiers des IVETF 'Vorschlag fur die diagnostische Herangehensweise bei Hunden mit Epilepsie'
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De Risio, Luisa, Bhatti, Sofie, Muñana, Karen, Penderis, Jacques, Stein, Veronika M, Tipold, Andrea, Berendt, Mette, Farqhuar, Robyn, Fischer, A, Long, Sam, Mandigers, P.J.J., Matiasek, Kaspar, Packer, Rowena M A, Pakozdy, Akos, Patterson, Ned, Platt, Simon, Potschka, Heidrun, Pumarola, Martí Batlle, Rusbridge, Clare, Volk, Holger A, Sub Neurologie, and dCSCA AVR
- Subjects
diagnosis ,seizure ,Dog ,epilepsy ,idiopathic epilepsy - Abstract
In 2015, the International Veterinary Epilepsy Task Force (IVETF) published the “Consensus Proposal: Diagnostic Approach to Epilepsy in Dogs“, proposing the basis for a standardized method of diagnostic procedures in patients suffering from seizures. The recommended modus operandi comprises two fundamental steps to clarify if the patient is truly suffering from epilepsy and to determine its underlying cause. The authors suggest a tier system of three confidence levels describing the reliability of the diagnosis “idiopathic epilepsy”. The authors of the consensus proposal emphasize that these recommendations will evolve over time with advances in neuroimaging, electroencephalography, and molecular genetics of canine epilepsy. In this article, the contents of the consensus proposal are summarized in German language.
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- 2016
42. Epilepsie aktuell - Zusammenfassung der Konsens papiers der IVETF zur Definition der Epilepsie, ihrer Klassifikation und der Terminologie sowie zur Genetik der Erkrankung bei Rassehunden
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Berendt, Mette, Hülsmeyer, Velia-Isabel, Bhatti, Sofie, De Risio, Luisa, Farquhar, Robyn, Fischer, A, Mandigers, P.J.J., Long, S., Sub Neurologie, and dCSCA AVR
- Subjects
Hunde ,Idiopathische Epilepsie ,Klassifikation ,Genetik ,Katzen - Abstract
Die International Veterinary Epilepsy Task Force (IVETF) hat 2015 sieben Veröffentlichungen mit einem Konsensus mit Richtlinien zur Klassifikation und Empfehlungen zu allen Aspekten der Epilepsie bei Hund und Katze in englischer Sprache publiziert (IVETF, 2015a, b). Im vorliegenden Artikel werden die Inhalte der Konsenspapiere „IVETF consensus report on epilepsy definition, classification and terminology in companion animals” und „IVETF’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs” in deutscher Sprache zusammengefasst, um die deutsche Tierärzteschaft über aktuelle Erkenntnisse und Neuerungen auf diesen Gebieten zu informieren. Im ersten Teil des Artikels werden die Notwendigkeit eines neuen Klassifikationssystems und einer einheitlichen Sprachregelung bei Epilepsie erläutert und die Vorschläge der IVETF hierfür vorgestellt. Der zweite Teil enthält eine kurze Zusammenfassung des aktuellen Wissensstandes zum verifizierten oder vermuteten genetischen Ursprung der idiopathischen Epilepsie bei verschiedenen Hunderassen.
- Published
- 2016
43. Creative surgeons - is that such a good idea?
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Langebaek, Rikke, Berendt, Mette, Toft, Nils, and Tanggaard, Lene
- Published
- 2016
44. Inter-observer agreement of canine and feline paroxysmal event semiology and classification by veterinary neurology specialists and non-specialists
- Author
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Packer, Rowena Ma, Berendt, Mette, Bhatti, Sofie, Charalambous, Marios, Cizinauskas, Sigitas, De Risio, Luisa, Farquhar, Robyn, Hampel, Rachel, Hill, Myfanwy, Mandigers, Paul Jj, Pakozdy, Akos, Preston, Stephanie M, Rusbridge, Clare, Stein, Veronika M, Taylor-Brown, Fran, Tipold, Andrea, Volk, Holger A, Sub Neurologie, CSCA AVM, Applied Veterinary Research, Sub Neurologie, CSCA AVM, and Applied Veterinary Research
- Subjects
Veterinary Medicine ,ABSENCE SEIZURES ,medicine.medical_specialty ,Neurology ,Veterinary neurology ,Inter observer agreement ,Movement ,Video Recording ,Audiology ,Autonomic Nervous System ,Cat Diseases ,Veterinarians ,Canine ,Agreement ,Feline ,Epilepsy ,Dogs ,Seizures ,Animals ,Medicine ,Veterinary Sciences ,Dog Diseases ,Psychiatry ,Event (probability theory) ,Observer Variation ,Paroxysmal event ,Behavior, Animal ,General Veterinary ,ILAE ,business.industry ,Video ,General Medicine ,Semiology ,medicine.disease ,veterinary(all) ,Seizure ,PREVALENCE ,KAPPA ,DOGS ,BIAS ,SEIZURE SEMIOLOGY ,Cats ,Epileptic seizure ,medicine.symptom ,business ,Kappa ,Research Article - Abstract
Background Advances in mobile technology mean vets are now commonly presented with videos of paroxysmal events by clients, but the consistency of the interpretation of these videos has not been investigated. The objective of this study was to investigate the level of agreement between vets (both neurology specialists and non-specialists) on the description and classification of videos depicting paroxysmal events, without knowing any results of diagnostic workup. An online questionnaire study was conducted, where participants watched 100 videos of dogs and cats exhibiting paroxysmal events and answered questions regarding: epileptic seizure presence (yes/no), seizure type, consciousness status, and the presence of motor, autonomic and neurobehavioural signs. Agreement statistics (percentage agreement and kappa) calculated for each variable, with prevalence indices calculated to aid their interpretation. Results Only a fair level of agreement (κ = 0.40) was found for epileptic seizure presence. Overall agreement of seizure type was moderate (κ = 0.44), with primary generalised seizures showing the highest level of agreement (κ = 0.60), and focal the lowest (κ =0.31). Fair agreement was found for consciousness status and the presence of autonomic signs (κ = 0.21–0.40), but poor agreement for neurobehavioral signs (κ = 0.16). Agreement for motor signs ranged from poor (κ = ≤ 0.20) to moderate (κ = 0.41–0.60). Differences between specialists and non-specialists were identified. Conclusions The relatively low levels of agreement described here highlight the need for further discussions between neurology experts regarding classifying and describing epileptic seizures, and additional training of non-specialists to facilitate accurate diagnosis. There is a need for diagnostic tools (e.g. electroencephalogram) able to differentiate between epileptic and non-epileptic paroxysms. Electronic supplementary material The online version of this article (doi:10.1186/s12917-015-0356-2) contains supplementary material, which is available to authorized users.
- Published
- 2015
45. Effect of Skull Type on the Relative Size of Cerebral Cortex and Lateral Ventricles in Dogs
- Author
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Pilegaard, Anders M., primary, Berendt, Mette, additional, Holst, Pernille, additional, Møller, Arne, additional, and McEvoy, Fintan J., additional
- Published
- 2017
- Full Text
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46. Spontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke
- Author
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Thomsen, Barbara Blicher, primary, Gredal, Hanne, additional, Wirenfeldt, Martin, additional, Kristensen, Bjarne Winther, additional, Clausen, Bettina Hjelm, additional, Larsen, Anders Elm, additional, Finsen, Bente, additional, Berendt, Mette, additional, and Lambertsen, Kate Lykke, additional
- Published
- 2017
- Full Text
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47. International veterinary epilepsy task force consensus proposal: diagnostic approach to epilepsy in dogs
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De Risio, Luisa, Bhatti, Sofie, Muñana, Karen, Penderis, Jacques, Stein, Veronika, Tipold, Andrea, Berendt, Mette, Farqhuar, Robyn, Fischer, Andrea, Long, Sam, Mandigers, Paul J J, Matiasek, Kaspar, Packer, Rowena M A, Pakozdy, Akos, Patterson, Ned, Platt, Simon, Podell, Michael, Potschka, Heidrun, Batlle, Martí Pumarola, Rusbridge, Clare, Volk, Holger A, Sub Neurologie, CSCA AVM, Applied Veterinary Research, Sub Neurologie, CSCA AVM, and Applied Veterinary Research
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Veterinary Medicine ,Veterinary medicine ,Internationality ,Urinalysis ,Neurological examination ,Status epilepticus ,Electroencephalography ,INHERITANCE ,PLEOCYTOSIS ,CLASSIFICATION ,Epilepsy ,SYMPTOMATIC EPILEPSY ,Dogs ,CLINICAL CHARACTERISTICS ,Neuroimaging ,Correspondence ,Diagnosis ,Dog ,medicine ,Animals ,Genetic Predisposition to Disease ,Veterinary Sciences ,Dog Diseases ,General Veterinary ,medicine.diagnostic_test ,business.industry ,STATUS EPILEPTICUS ,HEAD TREMOR ,Idiopathic epilepsy ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,veterinary(all) ,Seizure ,CEREBROSPINAL-FLUID ANALYSIS ,Practice Guidelines as Topic ,SEIZURES ,Epileptic seizure ,medicine.symptom ,business - Abstract
This article outlines the consensus proposal on diagnosis of epilepsy in dogs by the International Veterinary Epilepsy Task Force. The aim of this consensus proposal is to improve consistency in the diagnosis of epilepsy in the clinical and research settings. The diagnostic approach to the patient presenting with a history of suspected epileptic seizures incorporates two fundamental steps: to establish if the events the animal is demonstrating truly represent epileptic seizures and if so, to identify their underlying cause. Differentiation of epileptic seizures from other non-epileptic episodic paroxysmal events can be challenging. Criteria that can be used to make this differentiation are presented in detail and discussed. Criteria for the diagnosis of idiopathic epilepsy (IE) are described in a three-tier system. Tier I confidence level for the diagnosis of IE is based on a history of two or more unprovoked epileptic seizures occurring at least 24 h apart, age at epileptic seizure onset of between six months and six years, unremarkable inter-ictal physical and neurological examination, and no significant abnormalities on minimum data base blood tests and urinalysis. Tier II confidence level for the diagnosis of IE is based on the factors listed in tier I and unremarkable fasting and post-prandial bile acids, magnetic resonance imaging (MRI) of the brain (based on an epilepsy-specific brain MRI protocol) and cerebrospinal fluid (CSF) analysis. Tier III confidence level for the diagnosis of IE is based on the factors listed in tier I and II and identification of electroencephalographic abnormalities characteristic for seizure disorders. The authors recommend performing MRI of the brain and routine CSF analysis, after exclusion of reactive seizures, in dogs with age at epileptic seizure onset 6 years, inter-ictal neurological abnormalities consistent with intracranial neurolocalisation, status epilepticus or cluster seizure at epileptic seizure onset, or a previous presumptive diagnosis of IE and drug-resistance with a single antiepileptic drug titrated to the highest tolerable dose. This consensus article represents the basis for a more standardised diagnostic approach to the seizure patient. These recommendations will evolve over time with advances in neuroimaging, electroencephalography, and molecular genetics of canine epilepsy. Electronic supplementary material The online version of this article (doi:10.1186/s12917-015-0462-1) contains supplementary material, which is available to authorized users.
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- 2015
48. International veterinary epilepsy task force consensus report on epilepsy definition, classification and terminology in companion animals
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Berendt, Mette, Farquhar, Robyn G, Mandigers, Paul J J, Pakozdy, Akos, Bhatti, Sofie F M, De Risio, Luisa, Fischer, Andrea, Long, Sam, Matiasek, Kaspar, Muñana, Karen, Patterson, Edward E, Penderis, Jacques, Platt, Simon, Podell, Michael, Potschka, Heidrun, Pumarola, Martí Batlle, Rusbridge, Clare, Stein, Veronika M, Tipold, Andrea, Volk, Holger A, Sub Neurologie, CSCA AVM, Applied Veterinary Research, Sub Neurologie, CSCA AVM, and Applied Veterinary Research
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Veterinary Medicine ,medicine.medical_specialty ,Veterinary medicine ,Internationality ,ELECTROENCEPHALOGRAPHIC FINDINGS ,LONG-TERM ,First line ,MEDLINE ,CANINE EPILEPSY ,INHERITANCE ,Terminology ,Semiology ,Epilepsy ,Dogs ,CLINICAL CHARACTERISTICS ,IDIOPATHIC EPILEPSY ,SEIZURE CLASSIFICATION ,Seizures ,Terminology as Topic ,Correspondence ,medicine ,Dog ,Animals ,Veterinary Sciences ,Dog Diseases ,General Veterinary ,business.industry ,Task force ,LABRADOR RETRIEVERS ,General Medicine ,Pets ,medicine.disease ,Classification ,veterinary(all) ,RISK-FACTORS ,SHEPHERD DOGS ,business ,International league against epilepsy - Abstract
Dogs with epilepsy are among the commonest neurological patients in veterinary practice and therefore have historically attracted much attention with regard to definitions, clinical approach and management. A number of classification proposals for canine epilepsy have been published during the years reflecting always in parts the current proposals coming from the human epilepsy organisation the International League Against Epilepsy (ILAE). It has however not been possible to gain agreed consensus, “a common language”, for the classification and terminology used between veterinary and human neurologists and neuroscientists, practitioners, neuropharmacologists and neuropathologists. This has led to an unfortunate situation where different veterinary publications and textbook chapters on epilepsy merely reflect individual author preferences with respect to terminology, which can be confusing to the readers and influence the definition and diagnosis of epilepsy in first line practice and research studies.\ud \ud In this document the International Veterinary Epilepsy Task Force (IVETF) discusses current understanding of canine epilepsy and presents our 2015 proposal for terminology and classification of epilepsy and epileptic seizures. We propose a classification system which reflects new thoughts from the human ILAE but also roots in former well accepted terminology. We think that this classification system can be used by all stakeholders.
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- 2015
49. International Veterinary Epilepsy Task Force's current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs
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Hülsmeyer, Velia-Isabel, Fischer, Andrea, Mandigers, Paul J J, DeRisio, Luisa, Berendt, Mette, Rusbridge, Clare, Bhatti, Sofie F M, Pakozdy, Akos, Patterson, Edward E, Platt, Simon, Packer, Rowena M A, Volk, Holger A, Sub Neurologie, CSCA AVM, Applied Veterinary Research, Sub Neurologie, CSCA AVM, and Applied Veterinary Research
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Male ,Veterinary Medicine ,Veterinary medicine ,medicine.medical_specialty ,Aging ,Internationality ,Prevalence ,Disease ,Breeding ,BORDER COLLIE DOGS ,Crossbreed ,Epilepsy prevalence ,OCCURRING CANINE SEIZURES ,Epilepsy ,Dogs ,Sex Factors ,Epidemiology ,Correspondence ,medicine ,Dog ,Animals ,Genetic Predisposition to Disease ,Dog Diseases ,Veterinary Sciences ,FINNISH SPITZ DOGS ,LAGOTTO-ROMAGNOLO DOGS ,General Veterinary ,business.industry ,Idiopathic epilepsy ,LABRADOR RETRIEVERS ,General Medicine ,EXERCISE-INDUCED COLLAPSE ,NEURONAL CEROID-LIPOFUSCINOSIS ,medicine.disease ,veterinary(all) ,Breed ,Cohort ,ENGLISH SPRINGER-SPANIELS ,Epileptic seizure ,RISK-FACTORS ,Female ,medicine.symptom ,KING-CHARLES SPANIELS ,business ,Purebred - Abstract
Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in particular our knowledge of those breeds studied. However, these studies also frequently revealed differences between the investigated breeds with respect to clinical features, inheritance and prevalence rates. Awareness and observation of breed-specific differences is important for successful management of the dog with epilepsy in everyday clinical practice and furthermore may promote canine epilepsy research. The following manuscript reviews the evidence available for breeds which have been identified as being predisposed to idiopathic epilepsy with a proven or suspected genetic background, and highlights different breed specific clinical features (e.g. age at onset, sex, seizure type), treatment response, prevalence rates and proposed inheritance reported in the literature. In addition, certain breed-specific diseases that may act as potential differentials for idiopathic epilepsy are highlighted.
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- 2015
50. International Veterinary Epilepsy Task Force consensus proposal: medical treatment of canine epilepsy in Europe
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Bhatti, Sofie F M, De Risio, Luisa, Muñana, Karen, Penderis, Jacques, Stein, Veronika M, Tipold, Andrea, Berendt, Mette, Farquhar, Robyn G, Fischer, Andrea, Long, Sam, Löscher, Wolfgang, Mandigers, Paul J J, Matiasek, Kaspar, Pakozdy, Akos, Patterson, Edward E, Platt, Simon, Podell, Michael, Potschka, Heidrun, Rusbridge, Clare, Volk, Holger A, Sub Neurologie, CSCA AVM, Applied Veterinary Research, Sub Neurologie, CSCA AVM, and Applied Veterinary Research
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Drug ,Veterinary Medicine ,medicine.medical_specialty ,Veterinary medicine ,Veterinary Drugs ,Internationality ,ANTICONVULSANT DRUGS ,LONG-TERM ,media_common.quotation_subject ,MEDLINE ,Alternative medicine ,POTASSIUM-BROMIDE ,Epilepsy ,ANTIEPILEPTIC DRUG-THERAPY ,Dogs ,Correspondence ,REFRACTORY IDIOPATHIC EPILEPSY ,medicine ,Dog ,Animals ,Dog Diseases ,Veterinary Sciences ,Medical prescription ,media_common ,General Veterinary ,Medical treatment ,business.industry ,LABRADOR RETRIEVERS ,General Medicine ,medicine.disease ,veterinary(all) ,Europe ,Treatment ,THYROID-FUNCTION ,BORDER COLLIES ,Practice Guidelines as Topic ,Epileptic seizure ,ZONISAMIDE THERAPY ,RISK-FACTORS ,Anticonvulsants ,Thyroid function ,business - Abstract
In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which adjunctive AED can be advised if treatment with the initial drug is unsatisfactory, and 4) when treatment changes should be considered. In this consensus proposal, an overview is given on the aim of AED treatment, when to start long-term treatment in canine epilepsy and which veterinary AEDs are currently in use for dogs. The consensus proposal for drug treatment protocols, 1) is based on current published evidence-based literature, 2) considers the current legal framework of the cascade regulation for the prescription of veterinary drugs in Europe, and 3) reflects the authors' experience. With this paper it is aimed to provide a consensus for the management of canine idiopathic epilepsy. Furthermore, for the management of structural epilepsy AEDs are inevitable in addition to treating the underlying cause, if possible.
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- 2015
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