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2. Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition

Author

Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Hoff, Geir, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Dossus, Laure, Johansson, Mattias, Freisling, Heinz, Matta, Komodo, Huybrechts, Inge, Chen, Sairah L. F., B. Borch, Kristin, Sandanger, Torkjel M., H. Nøst, Therese, Dahm, Christina C., Antoniussen, Christian S., Tin Tin, Sandar, Fournier, Agnès, Marques, Chloé, Artaud, Fanny, Sánchez, Maria-José, Guevara, Marcela, Santiuste, Carmen, Agudo, Antonio, Bajracharya, Rashmita, Katzke, Verena, Ricceri, Fulvio, Agnoli, Claudia, Bergmann, Manuela M., Schulze, Matthias B., Panico, Salvatore, Masala, Giovanna, Tjønneland, Anne, Olsen, Anja, Stocks, Tanja, Manjer, Jonas, Aizpurua-Atxega, Amaia, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., and Ferrari, Pietro

Published
2024
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4. Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Ersoy Guller, Zeynep, Harewood, Rhea N., Weiderpass, Elisabete, Huybrechts, Inge, Jenab, Mazda, Huerta, José María, Sánchez, Maria-Jose, Jakszyn, Paula, Amiano, Pilar, Ardanaz, Eva, Agnoli, Claudia, Tumino, Rosario, Palli, Domenico, Skeie, Guri, Manjer, Jonas, Papier, Keren, Tjønneland, Anne, Eriksen, Anne Kirstine, Schulze, Matthias B., Kaaks, Rudolf, Katzke, Verena, Bergmann, Manuela M., Riboli, Elio, Gunter, Marc J., and Cross, Amanda J.

Published
2023
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5. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author

Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, Sánchez, María José, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, Ferrari, Pietro, Clarke, Robert, Boutron, Marie-Christine, Severi, Gianluca, MacDonald, Conor, Providencia, Rui, Masala, Giovanna, Zamora Ros, Raul, Boer, Jolanda, Verschuren, Wm Monique, Cawthon, Peggy, Schierbeck, Louise L, Cooper, Cyrus, Schulze, Matthias B, Bergmann, Manuela M, Hannemann, Anke, Kiechl, Stefan, Brenner, Hermann, van Schoor, Natasja M, Albertorio, Juan R, Sacerdote, Carlotta, Linneberg, Allan, Kårhus, LineL, Huerta, José María, Imaz, Liher, Joergensen, Christel, Ben-Shlomo, Yoav, Lundqvist, Annamari, Gallacher, John, Sattar, Naveed, Wood, Angela M, Wareham, Nicholas J, Nordestgaard, Børge G, Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S, and Burgess, Stephen

Published
2024
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6. Determinants of non- response to a second assessment of lifestyle factors and body weight in the EPIC-PANACEA study

Author

May Anne M, Adema Lotte E, Romaguera Dora, Vergnaud Anne-Claire, Agudo Antonio, Ekelund Ulf, Steffen Annika, Orfanos Philippos, Slimani Nadia, Rinaldi Sabina, Mouw Traci, Rohrmann Sabine, Hermann Silke, Boeing Heiner, Bergmann Manuela M, Jakobsen Marianne, Overvad Kim, Wareham Nicholas J, Gonzalez Carlos, Tjonneland Anne, Halkjaer Jytte, Key Timothy J, Spencer Elizabeth A, Hellstrom Veronica, Manjer Jonas, Hedblad Bo, Lund Eiliv, Braaten Tonje, Clavel-Chapelon Françoise, Boutron-Ruault Marie-Christine, Rodríguez Laudina, Sánchez Maria J, Dorronsoro Miren, Barricarte Aurelio, Huerta Jose, Naska Androniki, Trichopoulou Antonia, Palli Domenico, Pala Valeria, Norat Teresa, Mattiello Amalia, Tumino Rosario, van der A Daphne, Bueno-de-Mesquita H, Riboli Elio, and Peeters Petra HM

Subjects
Non-response, Non-participation, Lost-to-follow-up, Medicine (General), R5-920
Abstract

Abstract Background This paper discusses whether baseline demographic, socio-economic, health variables, length of follow-up and method of contacting the participants predict non-response to the invitation for a second assessment of lifestyle factors and body weight in the European multi-center EPIC-PANACEA study. Methods Over 500.000 participants from several centers in ten European countries recruited between 1992 and 2000 were contacted 2–11 years later to update data on lifestyle and body weight. Length of follow-up as well as the method of approaching differed between the collaborating study centers. Non-responders were compared with responders using multivariate logistic regression analyses. Results Overall response for the second assessment was high (81.6%). Compared to postal surveys, centers where the participants completed the questionnaire by phone attained a higher response. Response was also high in centers with a short follow-up period. Non-response was higher in participants who were male (odds ratio 1.09 (confidence interval 1.07; 1.11), aged under 40 years (1.96 (1.90; 2.02), living alone (1.40 (1.37; 1.43), less educated (1.35 (1.12; 1.19), of poorer health (1.33 (1.27; 1.39), reporting an unhealthy lifestyle and who had either a low (25, 1.08 (1.06; 1.10); especially ≥30 kg/m2, 1.26 (1.23; 1.29)). Conclusions Cohort studies may enhance cohort maintenance by paying particular attention to the subgroups that are most unlikely to respond and by an active recruitment strategy using telephone interviews.

Published
2012
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7. The association of education with body mass index and waist circumference in the EPIC-PANACEA study

Author

Vineis Paolo, Masala Giovanna, Tumino Rosario, Mattiello Amalia, Agnoli Claudia, Halkjær Jytte, Tjønneland Anne, Jakobsen Marianne, Overvad Kim, Bueno-de-Mesquita H Bas, van Boeckel Petra GA, Wareham Nicholas J, Khaw Kay-Tee, Crowe Francesca L, Rodríguez Laudina, Barricarte Aurelio, Dorronsoro Miren, Molina Esther, Tormo Maria-Jose, Travier Noemie, Romaguera Dora, Besson Herve, Kunst Anton, May Anne M, Linseisen Jakob, Rohrmann Sabine, Hermann Silke, Naska Androniki, Orfanos Philippos, Trichopoulou Antonia, Kaaks Rudolf, Bergmann Manuela M, Steffen Annika, Van Guelpen Bethany, Johansson Ingegerd, Borgquist Signe, Manjer Jonas, Braaten Tonje, Fagherazzi Guy, Clavel-Chapelon Françoise, Mouw Traci, Norat Teresa, Riboli Elio, Rinaldi Sabina, Slimani Nadia, and Peeters Petra HM

Subjects
socioeconomic status, education, BMI, waist circumference, cohort study, EPIC, Public aspects of medicine, RA1-1270
Abstract

Abstract Background To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Method This study included 141,230 male and 336,637 female EPIC-participants, who were recruited between 1992 and 2000. Education, which was assessed by questionnaire, was classified into four categories; BMI and WC, measured by trained personnel in most participating centers, were modeled as continuous dependent variables. Associations were estimated using multilevel mixed effects linear regression models. Results Compared with the lowest education level, BMI and WC were significantly lower for all three higher education categories, which was consistent for all countries. Women with university degree had a 2.1 kg/m2 lower BMI compared with women with lowest education level. For men, a statistically significant, but less pronounced difference was observed (1.3 kg/m2). The association between WC and education level was also of greater magnitude for women: compared with the lowest education level, average WC of women was lower by 5.2 cm for women in the highest category. For men the difference was 2.9 cm. Conclusion In this European cohort, there is an inverse association between higher BMI as well as higher WC and lower education level. Public Health Programs that aim to reduce overweight and obesity should primarily focus on the lower educated population.

Published
2011
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9. Metabolic syndrome and risk of incident diabetes: findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study

Author

Joost Hans-Georg, Bergmann Manuela M, Pischon Tobias, Schulze Matthias B, Ford Earl S, and Boeing Heiner

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Several aspects concerning the relationship between the metabolic syndrome and incident diabetes are incompletely understood including the magnitude of the risk estimate, potential gender differences in the associations between the metabolic syndrome and incident diabetes, the associations between the components of the metabolic syndrome and incident diabetes, and whether the metabolic syndrome provides additional prediction beyond its components. To shed light on these issues, we examined the prospective association between the metabolic syndrome defined by the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) and diabetes. Methods We used data for 2796 men and women aged 35–65 years from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study followed for an average of 6.9 years. This analysis employed a case-cohort design that included 697 participants who developed diabetes and 2099 participants who did not. Incident diabetes was identified on the basis of self-reports and verified by contacting the patient's attending physician. Results The adjusted hazard ratio for the NCEP definition was 4.62 (95% confidence interval [CI]: 3.90–5.48) and that for the IDF definition was 4.59 (95% CI: 3.84–5.50). The adjusted hazard ratios for the NCEP but not IDF definition were higher for women than men. When participants who had no cardiometabolic abnormalities were used as the reference group for the NCEP definition, the adjusted hazard ratio for having 3 or more abnormalities increased to 22.50 (95% CI: 11.21–45.19). Of the five components, abdominal obesity and hyperglycemia were most strongly associated with incident diabetes. Conclusion In this study population, both definitions of the metabolic syndrome provided similar estimates of relative risk for incident diabetes. The increase in risk for participants with the metabolic syndrome according to the NCEP definition was very large when contrasted with the risk among those who had no cardiometabolic abnormalities.

Published
2008
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10. A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk

Author

Mayén, Ana-Lucia, Viallon, Vivian, Botteri, Edoardo, Proust-Lima, Cecile, Bagnardi, Vincenzo, Batista, Veronica, Cross, Amanda J., Laouali, Nasser, MacDonald, Conor J., Severi, Gianluca, Katzke, Verena, Bergmann, Manuela M., Schulze, Mattias B., Tjønneland, Anne, Eriksen, Anne Kirstine, Dahm, Christina C., Antoniussen, Christian S., Jakszyn, Paula, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra M., Ardanaz, Eva, Travis, Ruth, Palli, Domenico, Sabina, Sieri, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Bueno-de-Mesquita, Bas, Derksen, Jeroen W. G., Sonestedt, Emily, Winkvist, Anna, Harlid, Sophia, Braaten, Tonje, Gram, Inger Torhild, Lukic, Marko, Jenab, Mazda, Riboli, Elio, Freisling, Heinz, Weiderpass, Elisabete, Gunter, Marc J., and Ferrari, Pietro

Published
2022
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12. Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort

Author

Winitzki, Doris, Zacharias, Helena U., Nadal, Jennifer, Baid-Agrawal, Seema, Schaeffner, Elke, Schmid, Matthias, Busch, Martin, Bergmann, Manuela M., Schultheiss, Ulla, Kotsis, Fruzsina, Stockmann, Helena, Meiselbach, Heike, Wolf, Gunter, Krane, Vera, Sommerer, Claudia, Eckardt, Kai-Uwe, Schneider, Markus P., Schlieper, Georg, Floege, Jürgen, and Saritas, Turgay

Published
2022
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13. Obesity is Associated With Increased Risk of Crohn’s disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies

Author

Amian, Pilar, Barricarte, Aurelio, Bergmann, Manuela M., Boutron-Ruault, Marie-Christine, Cross, Amanda, Hart, Andrew R., Kaaks, Rudolf, Key, Tim, Chirlaque López, María Dolores, Robert Luben, Masala, Giovanna, Manjer, Jonas, Olsen, Anja, Overvad, Kim, Palli, Domenico, Riboli, Elio, Sánchez, Maria José, Tumino, Rosario, Vermeulen, Roel, Verschuren, W. M. Monique, Wareham, Nick, Ananthakrishnan, Ashwin, Burke, Kristin, Lopes, Emily Walsh, Richter, James, Chan, Simon S.M., Chen, Ye, Casey, Kevin, Olen, Ola, Ludvigsson, Jonas F., Carbonnel, Franck, Oldenburg, Bas, Gunter, Marc J., Tjønneland, Anne, Grip, Olof, Lochhead, Paul, Chan, Andrew T., Wolk, Alicia, and Khalili, Hamed

Published
2022
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15. A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC

Author

Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A., Muller, David C., Papadopoulou, Areti, Heath, Alicia K., Critselis, Elena, Gunter, Marc J., Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A., Lopez, David S., Bergmann, Manuela M., Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, Srour, Bernard, Eriksen, Anne Kirstine, Boden, Stina, Johansson, Ingegerd, Nøst, Therese Haugdahl, Lukic, Marco, Ricceri, Fulvio, Ericson, Ulrika, Huerta, José María, Dahm, Christina C., Agnoli, Claudia, Amiano, Pilar Exezarreta, Tjønneland, Anne, Gurrea, Aurelio Barricarte, Bueno-de-Mesquita, Bas, Ardanaz, Eva, Berntsson, Jonna, Sánchez, Maria-Jose, Tumino, Rosario, Panico, Salvatore, Katzke, Verena, Jakszyn, Paula, Masala, Giovanna, Derksen, Jeroen W.G., Quirós, J. Ramón, Severi, Gianluca, Cross, Amanda J., Riboli, Ellio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K.

Published
2022
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17. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality : EPIC cohort study in 10 European countries

Author

Deschasaux, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Egnell, Manon, Srour, Bernard, Kesse-Guyot, Emmanuelle, Latino-Martel, Paule, Biessy, Carine, Casagrande, Corinne, Murphy, Neil, Jenab, Mazda, Ward, Heather A, Weiderpass, Elisabete, Overvad, Kim, Tjønneland, Anne, Rostgaard-Hansen, Agnetha Linn, Boutron-Ruault, Marie-Christine, Mancini, Francesca Romana, Mahamat-Saleh, Yahya, Kühn, Tilman, Katzke, Verena, Bergmann, Manuela M, Schulze, Matthias B, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Masala, Giovanna, Agnoli, Claudia, DeMagistris, Maria Santucci, Tumino, Rosario, Sacerdote, Carlotta, Boer, Jolanda MA, Verschuren, WM Monique, vanderSchouw, Yvonne T, Skeie, Guri, Braaten, Tonje, Redondo, M Luisa, Agudo, Antonio, Petrova, Dafina, Colorado-Yohar, Sandra M, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Ericson, Ulrika, Otten, Julia, Sundström, Björn, Wareham, Nicholas J, Forouhi, Nita G, Vineis, Paolo, Tsilidis, Konstantinos K, Knuppel, Anika, Papier, Keren, Ferrari, Pietro, Riboli, Elio, Gunter, Marc J, and Touvier1, Mathilde

Published
2020

19. Lifestyle changes in middle age and risk of cancer:evidence from the European Prospective Investigation into Cancer and Nutrition

Author

Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Hoff, Geir, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Dossus, Laure, Johansson, Mattias, Freisling, Heinz, Matta, Komodo, Huybrechts, Inge, Chen, Sairah L.F., B. Borch, Kristin, Sandanger, Torkjel M., H. Nøst, Therese, Dahm, Christina C., Antoniussen, Christian S., Tin Tin, Sandar, Fournier, Agnès, Marques, Chloé, Artaud, Fanny, Sánchez, Maria José, Guevara, Marcela, Santiuste, Carmen, Agudo, Antonio, Bajracharya, Rashmita, Katzke, Verena, Ricceri, Fulvio, Agnoli, Claudia, Bergmann, Manuela M., Schulze, Matthias B., Panico, Salvatore, Masala, Giovanna, Tjønneland, Anne, Olsen, Anja, Stocks, Tanja, Manjer, Jonas, Aizpurua-Atxega, Amaia, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., Ferrari, Pietro, Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Hoff, Geir, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Dossus, Laure, Johansson, Mattias, Freisling, Heinz, Matta, Komodo, Huybrechts, Inge, Chen, Sairah L.F., B. Borch, Kristin, Sandanger, Torkjel M., H. Nøst, Therese, Dahm, Christina C., Antoniussen, Christian S., Tin Tin, Sandar, Fournier, Agnès, Marques, Chloé, Artaud, Fanny, Sánchez, Maria José, Guevara, Marcela, Santiuste, Carmen, Agudo, Antonio, Bajracharya, Rashmita, Katzke, Verena, Ricceri, Fulvio, Agnoli, Claudia, Bergmann, Manuela M., Schulze, Matthias B., Panico, Salvatore, Masala, Giovanna, Tjønneland, Anne, Olsen, Anja, Stocks, Tanja, Manjer, Jonas, Aizpurua-Atxega, Amaia, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., and Ferrari, Pietro

Abstract

In this study, we aimed to provide novel evidence on the impact of changing lifestyle habits on cancer risk. In the EPIC cohort, 295,865 middle-aged participants returned a lifestyle questionnaire at baseline and during follow-up. At both timepoints, we calculated a healthy lifestyle index (HLI) score based on cigarette smoking, alcohol consumption, body mass index and physical activity. HLI ranged from 0 (most unfavourable) to 16 (most favourable). We estimated the association between HLI change and risk of lifestyle-related cancers—including cancer of the breast, lung, colorectum, stomach, liver, cervix, oesophagus, bladder, and others—using Cox regression models. We reported hazard ratios (HR) with 95% confidence intervals (CI). Median time between the two questionnaires was 5.7 years, median age at follow-up questionnaire was 59 years. After the follow-up questionnaire, we observed 14,933 lifestyle-related cancers over a median follow-up of 7.8 years. Each unit increase in the HLI score was associated with 4% lower risk of lifestyle-related cancers (HR 0.96; 95%CI 0.95–0.97). Among participants in the top HLI third at baseline (HLI > 11), those in the bottom third at follow-up (HLI ≤ 9) had 21% higher risk of lifestyle-related cancers (HR 1.21; 95%CI 1.07–1.37) than those remaining in the top third. Among participants in the bottom HLI third at baseline, those in the top third at follow-up had 25% lower risk of lifestyle-related cancers (HR 0.75; 95%CI 0.65–0.86) than those remaining in the bottom third. These results indicate that lifestyle changes in middle age may have a significant impact on cancer risk.

Published
2024

21. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

Author

Holmes, Michael V, Dale, Caroline E, Zuccolo, Luisa, Silverwood, Richard J, Guo, Yiran, Ye, Zheng, Prieto-Merino, David, Dehghan, Abbas, Trompet, Stella, Wong, Andrew, Cavadino, Alana, Drogan, Dagmar, Padmanabhan, Sandosh, Li, Shanshan, Yesupriya, Ajay, Leusink, Maarten, Sundstrom, Johan, Hubacek, Jaroslav A, Pikhart, Hynek, Swerdlow, Daniel I, Panayiotou, Andrie G, Borinskaya, Svetlana A, Finan, Chris, Shah, Sonia, Kuchenbaecker, Karoline B, Shah, Tina, Engmann, Jorgen, Folkersen, Lasse, Eriksson, Per, Ricceri, Fulvio, Melander, Olle, Sacerdote, Carlotta, Gamble, Dale M, Rayaprolu, Sruti, Ross, Owen A, McLachlan, Stela, Vikhireva, Olga, Sluijs, Ivonne, Scott, Robert A, Adamkova, Vera, Flicker, Leon, Bockxmeer, Frank M van, Power, Christine, Marques-Vidal, Pedro, Meade, Tom, Marmot, Michael G, Ferro, Jose M, Paulos-Pinheiro, Sofia, Humphries, Steve E, Talmud, Philippa J, Mateo Leach, Irene, Verweij, Niek, Linneberg, Allan, Skaaby, Tea, Doevendans, Pieter A, Cramer, Maarten J, van der Harst, Pim, Klungel, Olaf H, Dowling, Nicole F, Dominiczak, Anna F, Kumari, Meena, Nicolaides, Andrew N, Weikert, Cornelia, Boeing, Heiner, Ebrahim, Shah, Gaunt, Tom R, Price, Jackie F, Lannfelt, Lars, Peasey, Anne, Kubinova, Ruzena, Pajak, Andrzej, Malyutina, Sofia, Voevoda, Mikhail I, Tamosiunas, Abdonas, Maitland-van der Zee, Anke H, Norman, Paul E, Hankey, Graeme J, Bergmann, Manuela M, Hofman, Albert, Franco, Oscar H, Cooper, Jackie, Palmen, Jutta, Spiering, Wilko, de Jong, Pim A, Kuh, Diana, Hardy, Rebecca, Uitterlinden, Andre G, Ikram, M Arfan, Ford, Ian, Hyppönen, Elina, Almeida, Osvaldo P, Wareham, Nicholas J, Khaw, Kay-Tee, Hamsten, Anders, Husemoen, Lise Lotte N, Tjønneland, Anne, Tolstrup, Janne S, Rimm, Eric, Beulens, Joline WJ, and Verschuren, WM Monique

Subjects
InterAct Consortium, Humans, Coronary Disease, Alcohol Dehydrogenase, Genetic Markers, Models, Statistical, Alcohol Drinking, Genotype, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Female, Male, Stroke, Mendelian Randomization Analysis, Biomarkers, General & Internal Medicine, Clinical Sciences, Public Health and Health Services
Abstract

ObjectiveTo use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.DesignMendelian randomisation meta-analysis of 56 epidemiological studies.Participants261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers.Main outcome measuresOdds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption.ResultsCarriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m(2)). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)).ConclusionsIndividuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.

Published
2014

22. Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)

Author

Michaud, Dominique S, Vrieling, Alina, Jiao, Li, Mendelsohn, Julie B, Steplowski, Emily, Lynch, Shannon M, Wactawski-Wende, Jean, Arslan, Alan A, Bas Bueno-de-Mesquita, H, Fuchs, Charles S, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Petersen, Gloria, Zheng, Wei, Allen, Naomi, Ammundadottir, Laufey, Bergmann, Manuela M, Boffetta, Paolo, Buring, Julie E, Canzian, Federico, Chanock, Stephen J, Clavel-Chapelon, Françoise, Clipp, Sandra, Freiberg, Matthew S, Michael Gaziano, J, Giovannucci, Edward L, Hankinson, Susan, Hartge, Patricia, Hoover, Robert N, Allan Hubbell, F, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin, Kooperberg, Charles, Kraft, Peter, Manjer, Jonas, Navarro, Carmen, Peeters, Petra HM, Shu, Xiao-Ou, Stevens, Victoria, Thomas, Gilles, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Tumino, Rosario, Vineis, Paolo, Virtamo, Jarmo, Wallace, Robert, Wolpin, Brian M, Yu, Kai, Zeleniuch-Jacquotte, Anne, and Stolzenberg-Solomon, Rachael Z

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Alcoholism, Alcohol Use and Health, Cancer, Digestive Diseases, Pancreatic Cancer, Rare Diseases, Clinical Research, Substance Misuse, Oral and gastrointestinal, Good Health and Well Being, Aged, Alcohol Drinking, Case-Control Studies, Cohort Studies, Female, Humans, Male, Pancreatic Neoplasms, Prospective Studies, Alcohol, Pancreatic cancer, Pooled analysis, Oncology and Carcinogenesis, Public Health and Health Services, Epidemiology, Oncology and carcinogenesis
Abstract

The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case-control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86-2.23, for 60 or more g/day vs. >0 to

Published
2010

24. Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses

Author

Seyed Khoei, Nazlisadat, Jenab, Mazda, Murphy, Neil, Banbury, Barbara L., Carreras-Torres, Robert, Viallon, Vivian, Kühn, Tilman, Bueno-de-Mesquita, Bas, Aleksandrova, Krasimira, Cross, Amanda J., Weiderpass, Elisabete, Stepien, Magdalena, Bulmer, Andrew, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Carbonnel, Franck, Katzke, Verena, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Karakatsani, Anna, Martimianaki, Georgia, Palli, Domenico, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Merino, Susana, Bonet, Catalina, Rodríguez-Barranco, Miguel, Gil, Leire, Chirlaque, Maria-Dolores, Ardanaz, Eva, Myte, Robin, Hultdin, Johan, Perez-Cornago, Aurora, Aune, Dagfinn, Tsilidis, Konstantinos K., Albanes, Demetrius, Baron, John A., Berndt, Sonja I., Bézieau, Stéphane, Brenner, Hermann, Campbell, Peter T., Casey, Graham, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Cotterchio, Michelle, Gallinger, Steven, Gruber, Stephen B., Haile, Robert W., Hampe, Jochen, Hoffmeister, Michael, Hopper, John L., Hsu, Li, Huyghe, Jeroen R., Jenkins, Mark A., Joshi, Amit D., Kampman, Ellen, Larsson, Susanna C., Le Marchand, Loic, Li, Christopher I., Li, Li, Lindblom, Annika, Lindor, Noralane M., Martín, Vicente, Moreno, Victor, Newcomb, Polly A., Offit, Kenneth, Ogino, Shuji, Parfrey, Patrick S., Pharoah, Paul D. P., Rennert, Gad, Sakoda, Lori C., Schafmayer, Clemens, Schmit, Stephanie L., Schoen, Robert E., Slattery, Martha L., Thibodeau, Stephen N., Ulrich, Cornelia M., van Duijnhoven, Franzel J. B., Weigl, Korbinian, Weinstein, Stephanie J., White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Zhang, Xuehong, Ferrari, Pietro, Anton, Gabriele, Peters, Annette, Peters, Ulrike, Gunter, Marc J., Wagner, Karl-Heinz, and Freisling, Heinz

Published
2020
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25. The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium

Author

Guida, Florence, Tan, Vanessa Y., Corbin, Laura J., Smith-Byrne, Karl, Alcala, Karine, Langenberg, Claudia, Stewart, Isobel D., Butterworth, Adam S., Surendran, Praveen, Achaintre, David, Adamski, Jerzy, Amiano Exezarreta, Pilar, Bergmann, Manuela M., Bull, Caroline J., Dahm, Christina C., Gicquiau, Audrey, Giles, Graham G., Gunter, Marc J., Haller, Toomas, Langhammer, Arnulf, Larose, Tricia L., Ljungberg, Börje, Metspalu, Andres, Milne, Roger L., Muller, David C., Nøst, Therese H., Pettersen Sørgjerd, Elin, Prehn, Cornelia, Riboli, Elio, Rinaldi, Sabina, Rothwell, Joseph A., Scalbert, Augustin, Schmidt, Julie A., Severi, Gianluca, Sieri, Sabina, Vermeulen, Roel, Vincent, Emma E., Waldenberger, Melanie, Timpson, Nicholas J., and Johansson, Mattias

Subjects
Kidney cancer -- Risk factors -- Development and progression -- Physiological aspects, Metabolites -- Health aspects -- Measurement, Body mass index, Biological sciences
Abstract

Background Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we sought to identify circulating metabolites that predispose kidney cancer and to evaluate the extent to which they are influenced by body mass index (BMI). Methods and findings We assessed the association between circulating levels of 1,416 metabolites and incident kidney cancer using pre-diagnostic blood samples from up to 1,305 kidney cancer case-control pairs from 5 prospective cohort studies. Cases were diagnosed on average 8 years after blood collection. We found 25 metabolites robustly associated with kidney cancer risk. In particular, 14 glycerophospholipids (GPLs) were inversely associated with risk, including 8 phosphatidylcholines (PCs) and 2 plasmalogens. The PC with the strongest association was PC ae C34:3 with an odds ratio (OR) for 1 standard deviation (SD) increment of 0.75 (95% confidence interval [CI]: 0.68 to 0.83, p = 2.6 x 10.sup.-8). In contrast, 4 amino acids, including glutamate (OR for 1 SD = 1.39, 95% CI: 1.20 to 1.60, p = 1.6 x 10.sup.-5 ), were positively associated with risk. Adjusting for BMI partly attenuated the risk association for some-but not all-metabolites, whereas other known risk factors of kidney cancer, such as smoking and alcohol consumption, had minimal impact on the observed associations. A mendelian randomisation (MR) analysis of the influence of BMI on the blood metabolome highlighted that some metabolites associated with kidney cancer risk are influenced by BMI. Specifically, elevated BMI appeared to decrease levels of several GPLs that were also found inversely associated with kidney cancer risk (e.g., -0.17 SD change [ß.sub.BMI ] in 1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2) levels per SD change in BMI, p = 3.4 x 10.sup.-5). BMI was also associated with increased levels of glutamate (ß.sub.BMI : 0.12, p = 1.5 x 10.sup.-3). While our results were robust across the participating studies, they were limited to study participants of European descent, and it will, therefore, be important to evaluate if our findings can be generalised to populations with different genetic backgrounds. Conclusions This study suggests a potentially important role of the blood metabolome in kidney cancer aetiology by highlighting a wide range of metabolites associated with the risk of developing kidney cancer and the extent to which changes in levels of these metabolites are driven by BMI-the principal modifiable risk factor of kidney cancer., Author(s): Florence Guida 1, Vanessa Y. Tan 2,3, Laura J. Corbin 2,3, Karl Smith-Byrne 1, Karine Alcala 1, Claudia Langenberg 4, Isobel D. Stewart 4, Adam S. Butterworth 5,6,7,8, Praveen [...]

Published
2021
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29. Lifestyle factors for the prevention of inflammatory bowel disease

Author

Lopes, Emily W., Chan, Simon S. M., Song, Mingyang, Ludvigsson, Jonas F., Hakansson, Niclas, Lochhead, Paul, Clark, Allan, Burke, Kristin E., Ananthakrishnan, Ashwin N., Cross, Amanda J., Palli, Domenico, Bergmann, Manuela M., Richter, James M., Chan, Andrew T., Olen, Ola, Wolk, Alicja, Khalili, Hamed, Lopes, Emily W., Chan, Simon S. M., Song, Mingyang, Ludvigsson, Jonas F., Hakansson, Niclas, Lochhead, Paul, Clark, Allan, Burke, Kristin E., Ananthakrishnan, Ashwin N., Cross, Amanda J., Palli, Domenico, Bergmann, Manuela M., Richter, James M., Chan, Andrew T., Olen, Ola, Wolk, Alicja, and Khalili, Hamed

Abstract

ObjectiveTo estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. DesignIn a prospective cohort study of US adults from the Nurses' Health Study (NHS; n=72 290), NHSII (n=93 909) and Health Professionals Follow-up Study (HPFS; n=41 871), we created modifiable risk scores (MRS; 0-6) for CD and UC based on established lifestyle risk factors, and healthy lifestyle scores (HLS; 0-9) derived from American healthy lifestyle recommendations. We calculated the population attributable risk by comparing the incidence of CD and UC between low-risk (CD-MRS <= 1, UC-MRS <= 2, HLS >= 7) and high-risk groups. We externally validated our findings in three European cohorts: the Swedish Mammography Cohort (n=37 275), Cohort of Swedish Men (n=40 810) and European Prospective Investigation into Cancer and Nutrition (n=404 144). ResultsOver 5 117 021 person-years of follow-up (NHS, HPFS: 1986-2016; NHSII: 1991-2017), we documented 346 CD and 456 UC cases. Adherence to a low MRS could have prevented 42.9% (95% CI 12.2% to 66.1%) of CD and 44.4% (95% CI 9.0% to 69.8%) of UC cases. Similarly, adherence to a healthy lifestyle could have prevented 61.1% (95% CI 16.8% to 84.9%) of CD and 42.2% (95% CI 1.7% to 70.9%) of UC cases. In our validation cohorts, adherence to a low MRS and healthy lifestyle could have, respectively, prevented 43.9%-51.2% and 48.8%-60.4% of CD cases and 20.6%-27.8% and 46.8%-56.3% of UC cases. ConclusionsAcross six US and European cohorts, a substantial burden of inflammatory bowel diseases risk may be preventable through lifestyle modification.

Published
2023
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30. Diet and lifestyle in relation to small intestinal cancer risk:findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Ersoy Guller, Zeynep, Harewood, Rhea N., Weiderpass, Elisabete, Huybrechts, Inge, Jenab, Mazda, Huerta, José María, Sánchez, Maria Jose, Jakszyn, Paula, Amiano, Pilar, Ardanaz, Eva, Agnoli, Claudia, Tumino, Rosario, Palli, Domenico, Skeie, Guri, Manjer, Jonas, Papier, Keren, Tjønneland, Anne, Eriksen, Anne Kirstine, Schulze, Matthias B., Kaaks, Rudolf, Katzke, Verena, Bergmann, Manuela M., Riboli, Elio, Gunter, Marc J., Cross, Amanda J., Ersoy Guller, Zeynep, Harewood, Rhea N., Weiderpass, Elisabete, Huybrechts, Inge, Jenab, Mazda, Huerta, José María, Sánchez, Maria Jose, Jakszyn, Paula, Amiano, Pilar, Ardanaz, Eva, Agnoli, Claudia, Tumino, Rosario, Palli, Domenico, Skeie, Guri, Manjer, Jonas, Papier, Keren, Tjønneland, Anne, Eriksen, Anne Kirstine, Schulze, Matthias B., Kaaks, Rudolf, Katzke, Verena, Bergmann, Manuela M., Riboli, Elio, Gunter, Marc J., and Cross, Amanda J.

Abstract

Purpose The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype. Methods We analysed 450,107 participants enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. Cox proportional hazards models were used to estimate univariable and multivariable hazard ratios (HRs) and 95% confidence intervals (CIs). Results During an average of 14.1 years of follow-up, 160 incident SICs (62 carcinoids, 51 adenocarcinomas) were identified. Whilst univariable models revealed a positive association for current versus never smokers and SIC (HR, 95% CI: 1.77, 1.21–2.60), this association attenuated in multivariable models. In energy-adjusted models, there was an inverse association across vegetable intake tertiles for SIC overall (HRT3vsT1, 95% CI: 0.48, 0.32–0.71, p-trend: < 0.001) and for carcinoids (HRT3vsT1, 95% CI: 0.44, 0.24–0.82, p-trend: 0.01); however, these attenuated in multivariable models. Total fat was also inversely associated with total SIC and both subtypes but only in the second tertile (SIC univariable HRT2vsT1, 95% CI: 0.57, 0.38–0.84; SIC multivariable HRT2vsT1, 95% CI: 0.55, 0.37–0.81). Physical activity, intake of alcohol, red or processed meat, dairy products, or fibre were not associated with SIC. Conclusion These exploratory analyses found limited evidence for a role of modifiable risk factors in SIC aetiology. However, sample size was limited, particularly for histologic subtypes; therefore, larger studies are needed to delineate these associations and robustly identify risk factors for SIC., Purpose: The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype. Methods: We analysed 450,107 participants enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. Cox proportional hazards models were used to estimate univariable and multivariable hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During an average of 14.1 years of follow-up, 160 incident SICs (62 carcinoids, 51 adenocarcinomas) were identified. Whilst univariable models revealed a positive association for current versus never smokers and SIC (HR, 95% CI: 1.77, 1.21–2.60), this association attenuated in multivariable models. In energy-adjusted models, there was an inverse association across vegetable intake tertiles for SIC overall (HRT3vsT1, 95% CI: 0.48, 0.32–0.71, p-trend: < 0.001) and for carcinoids (HRT3vsT1, 95% CI: 0.44, 0.24–0.82, p-trend: 0.01); however, these attenuated in multivariable models. Total fat was also inversely associated with total SIC and both subtypes but only in the second tertile (SIC univariable HRT2vsT1, 95% CI: 0.57, 0.38–0.84; SIC multivariable HRT2vsT1, 95% CI: 0.55, 0.37–0.81). Physical activity, intake of alcohol, red or processed meat, dairy products, or fibre were not associated with SIC. Conclusion: These exploratory analyses found limited evidence for a role of modifiable risk factors in SIC aetiology. However, sample size was limited, particularly for histologic subtypes; therefore, larger studies are needed to delineate these associations and robustly identify risk factors for SIC.

Published
2023

32. An experimental approach to training interoceptive sensitivity

Author

Warschburger, Petra (Prof. Dr.), Wortmann, Hanna R. (M. Sc.), Gisch, Ulrike A. (PhD), Baer, Nadja-Raphaela (Dr.rer.medic.), Schenk, Liane (PhD), Anton, Verena, and Bergmann, Manuela M. (PhD)

Subjects
ddc:570, Extern, Strukturbereich Kognitionswissenschaften
Abstract

Background Eating in absence of hunger is quite common and often associated with an increased energy intake co-existent with a poorer food choice. Intuitive eating (IE), i.e., eating in accordance with internal hunger and satiety cues, may protect from overeating. IE, however, requires accurate perception and processing of one’s own bodily signals, also referred to as interoceptive sensitivity. Training interoceptive sensitivity might therefore be an effective method to promote IE and prevent overeating. As most studies on eating behavior are conducted in younger adults and close social relationships influence health-related behavior, this study focuses on middle-aged and older couples. Methods The present pilot randomized intervention study aims at investigating the feasibility and effectiveness of a 21-day mindfulness-based training program designed to increase interoceptive sensitivity. A total of N = 60 couples participating in the NutriAct Family Study, aged 50–80 years, will be recruited. This randomized-controlled intervention study comprises three measurement points (pre-intervention, post-intervention, 4-week follow-up) and a 21-day training that consists of daily mindfulness-based guided audio exercises (e.g., body scan). A three-arm intervention study design is applied to compare two intervention groups (training together as a couple vs. training alone) with a control group (no training). Each measurement point includes the assessment of self-reported and objective indicators of interoceptive sensitivity (primary outcome), self-reported indicators of intuitive and maladaptive eating (secondary outcomes), and additional variables. A training evaluation applying focus group discussions will be conducted to assess participants’ overall acceptance of the training and its feasibility. Discussion By investigating the feasibility and effectiveness of a mindfulness-based training program to increase interoceptive sensitivity, the present study will contribute to a deeper understanding of how to promote healthy eating in older age.

Published
2023

33. Exploring the longitudinal stability of food neophilia and dietary quality and their prospective relationship in older adults

Author

Wortmann, Hanna R., Gisch, Ulrike A. (Prof. Dr.), Bergmann, Manuela M. (Dr.), and Warschburger, Petra (Prof. Dr.)

Subjects
ddc:610, Strukturbereich Kognitionswissenschaften
Abstract

Poor dietary quality is a major cause of morbidity, making the promotion of healthy eating a societal priority. Older adults are a critical target group for promoting healthy eating to enable healthy aging. One factor suggested to promote healthy eating is the willingness to try unfamiliar foods, referred to as food neophilia. This two-wave longitudinal study explored the stability of food neophilia and dietary quality and their prospective relationship over three years, analyzing self-reported data from N = 960 older adults (MT1 = 63.4, range = 50–84) participating in the NutriAct Family Study (NFS) in a cross-lagged panel design. Dietary quality was rated using the NutriAct diet score, based on the current evidence for chronic disease prevention. Food neophilia was measured using the Variety Seeking Tendency Scale. The analyses revealed high a longitudinal stability of both constructs and a small positive cross-sectional correlation between them. Food neophilia had no prospective effect on dietary quality, whereas a very small positive prospective effect of dietary quality on food neophilia was found. Our findings give initial insights into the positive relation of food neophilia and a health-promoting diet in aging and underscore the need for more in-depth research, e.g., on the constructs’ developmental trajectories and potential critical windows of opportunity for promoting food neophilia.

Published
2023

34. Lifestyle factors for the prevention of inflammatory bowel disease

Author

Lopes, Emily W, primary, Chan, Simon S M, additional, Song, Mingyang, additional, Ludvigsson, Jonas F, additional, Håkansson, Niclas, additional, Lochhead, Paul, additional, Clark, Allan, additional, Burke, Kristin E, additional, Ananthakrishnan, Ashwin N, additional, Cross, Amanda J, additional, Palli, Domenico, additional, Bergmann, Manuela M, additional, Richter, James M, additional, Chan, Andrew T, additional, Olén, Ola, additional, Wolk, Alicja, additional, and Khalili, Hamed, additional

Published
2022
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36. An experimental approach to training interoceptive sensitivity: study protocol for a pilot randomized controlled trial

Author

Warschburger, Petra, Wortmann, Hanna R., Gisch, Ulrike A., Baer, Nadja-Raphaela, Schenk, Liane, Anton, Verena, and Bergmann, Manuela M.

Subjects
Nutrition and Dietetics, Medicine (miscellaneous), 570 Biowissenschaften, Biologie
Abstract

Background Eating in absence of hunger is quite common and often associated with an increased energy intake co-existent with a poorer food choice. Intuitive eating (IE), i.e., eating in accordance with internal hunger and satiety cues, may protect from overeating. IE, however, requires accurate perception and processing of one’s own bodily signals, also referred to as interoceptive sensitivity. Training interoceptive sensitivity might therefore be an effective method to promote IE and prevent overeating. As most studies on eating behavior are conducted in younger adults and close social relationships influence health-related behavior, this study focuses on middle-aged and older couples. Methods The present pilot randomized intervention study aims at investigating the feasibility and effectiveness of a 21-day mindfulness-based training program designed to increase interoceptive sensitivity. A total of N = 60 couples participating in the NutriAct Family Study, aged 50–80 years, will be recruited. This randomized-controlled intervention study comprises three measurement points (pre-intervention, post-intervention, 4-week follow-up) and a 21-day training that consists of daily mindfulness-based guided audio exercises (e.g., body scan). A three-arm intervention study design is applied to compare two intervention groups (training together as a couple vs. training alone) with a control group (no training). Each measurement point includes the assessment of self-reported and objective indicators of interoceptive sensitivity (primary outcome), self-reported indicators of intuitive and maladaptive eating (secondary outcomes), and additional variables. A training evaluation applying focus group discussions will be conducted to assess participants’ overall acceptance of the training and its feasibility. Discussion By investigating the feasibility and effectiveness of a mindfulness-based training program to increase interoceptive sensitivity, the present study will contribute to a deeper understanding of how to promote healthy eating in older age., Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe; 826

Published
2023
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37. Fish consumption and mortality in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Engeset, Dagrun, Braaten, Tonje, Teucher, Birgit, Kühn, Tilman, Bueno-de-Mesquita, H. B., Leenders, Max, Agudo, Antonio, Bergmann, Manuela M., Valanou, Elisavet, Naska, Androniki, Trichopoulou, Antonia, Key, Timothy J., Crowe, Francesca L., Overvad, Kim, Sonestedt, Emily, Mattiello, Amalia, Peeters, Petra H., Wennberg, Maria, Jansson, Jan Håkan, Boutron-Ruault, Marie-Christine, Dossus, Laure, Dartois, Laureen, Li, Kuanrong, Barricarte, Aurelio, Ward, Heather, Riboli, Elio, Agnoli, Claudia, Huerta, José María, Sánchez, María-José, Tumino, Rosario, Altzibar, Jone M., Vineis, Paolo, Masala, Giovanna, Ferrari, Pietro, Muller, David C., Johansson, Mattias, Redondo, M. Luisa, Tjønneland, Anne, Olsen, Anja, Olsen, Karina Standahl, Brustad, Magritt, Skeie, Guri, and Lund, Eiliv

Published
2015

41. Prediagnostic Serum Vitamin D Levels and the Risk of Crohn’s Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study

Author

Opstelten, Jorrit L, Chan, Simon S M, Hart, Andrew R, van Schaik, Fiona D M, Siersema, Peter D, Lentjes, Eef G W M, Khaw, Kay-Tee, Luben, Robert, Key, Timothy J, Boeing, Heiner, Bergmann, Manuela M, Overvad, Kim, Palli, Domenico, Masala, Giovanna, Racine, Antoine, Carbonnel, Franck, Boutron-Ruault, Marie-Christine, Tjønneland, Anne, Olsen, Anja, Andersen, Vibeke, Kaaks, Rudolf, Kühn, Tilman, Tumino, Rosario, Trichopoulou, Antonia, Peeters, Petra H M, Verschuren, W M Monique, Witteman, Ben J M, and Oldenburg, Bas

Published
2018
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42. Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data

Author

IMPROVE study group, The InterAct Consortium, Holmes, Michael V, Dale, Caroline E, Zuccolo, Luisa, Silverwood, Richard J, Guo, Yiran, Ye, Zheng, Prieto-Merino, David, Dehghan, Abbas, Trompet, Stella, Wong, Andrew, Cavadino, Alana, Drogan, Dagmar, Padmanabhan, Sandosh, Li, Shanshan, Yesupriya, Ajay, Leusink, Maarten, Sundstrom, Johan, Hubacek, Jaroslav A, Pikhart, Hynek, Swerdlow, Daniel I, Panayiotou, Andrie G, Borinskaya, Svetlana A, Finan, Chris, Shah, Sonia, Kuchenbaecker, Karoline B, Shah, Tina, Engmann, Jorgen, Folkersen, Lasse, Eriksson, Per, Ricceri, Fulvio, Melander, Olle, Sacerdote, Carlotta, Gamble, Dale M, Rayaprolu, Sruti, Ross, Owen A, McLachlan, Stela, Vikhireva, Olga, Sluijs, Ivonne, Scott, Robert A, Adamkova, Vera, Flicker, Leon, van Bockxmeer, Frank M, Power, Christine, Marques-Vidal, Pedro, Meade, Tom, Marmot, Michael G, Ferro, Jose M, Paulos-Pinheiro, Sofia, Humphries, Steve E, Talmud, Philippa J, Leach, Irene Mateo, Verweij, Niek, Linneberg, Allan, Skaaby, Tea, Doevendans, Pieter A, Cramer, Maarten J, van der Harst, Pim, Klungel, Olaf H, Dowling, Nicole F, Dominiczak, Anna F, Kumari, Meena, Nicolaides, Andrew N, Weikert, Cornelia, Boeing, Heiner, Ebrahim, Shah, Gaunt, Tom R, Price, Jackie F, Lannfelt, Lars, Peasey, Anne, Kubinova, Ruzena, Pajak, Andrzej, Malyutina, Sofia, Voevoda, Mikhail I, Tamosiunas, Abdonas, Maitland-vanderZee, Anke H, Norman, Paul E, Hankey, Graeme J, Bergmann, Manuela M, Hofman, Albert, Franco, Oscar H, Cooper, Jackie, Palmen, Jutta, Spiering, Wilko, de Jong, Pim A, Kuh, Diana, Hardy, Rebecca, Uitterlinden, Andre G, Ikram, M Arfan, Ford, Ian, Hyppönen, Elina, Almeida, Osvaldo P, Wareham, Nicholas J, Khaw, Kay-Tee, Hamsten, Anders, Husemoen, Lise Lotte N, Tjønneland, Anne, Tolstrup, Janne S, Rimm, Eric, Beulens, Joline W J, Verschuren, W M Monique, Onland-Moret, N Charlotte, Hofker, Marten H, Wannamethee, S Goya, Whincup, Peter H, Morris, Richard, Vicente, Astrid M, Watkins, Hugh, Farrall, Martin, Jukema, J Wouter, Meschia, James, Cupples, L Adrienne, Sharp, Stephen J, Fornage, Myriam, Kooperberg, Charles, LaCroix, Andrea Z, Dai, James Y, Lanktree, Matthew B, Siscovick, David S, Jorgenson, Eric, Spring, Bonnie, Coresh, Josef, Li, Yun R, Buxbaum, Sarah G, Schreiner, Pamela J, Curtis, R, Y Tsai, Michael, Patel, Sanjay R, Redline, Susan, Johnson, Andrew D, Hoogeveen, Ron C, Hakonarson, Hakon, Rotter, Jerome I, Boerwinkle, Eric, de Bakker, Paul I W, Kivimaki, Mika, Asselbergs, Folkert W, Sattar, Naveed, Lawlor, Debbie A, Whittaker, John, Smith, George Davey, Mukamal, Kenneth, Psaty, Bruce M, Wilson, James G, Lange, Leslie A, Hamidovic, Ajna, Hingorani, Aroon D, Nordestgaard, Børge G, Bobak, Martin, Leon, David A, Langenberg, Claudia, Palmer, Tom M, Reiner, Alex P, Keating, Brendan J, Dudbridge, Frank, and Casas, Juan P

Published
2014

43. Fruit and vegetable intake and cause-specific mortality in the EPIC study

Author

Leenders, Max, Boshuizen, Hendriek C., Ferrari, Pietro, Siersema, Peter D., Overvad, Kim, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Dossus, Laure, Dartois, Laureen, Kaaks, Rudolf, Li, Kuanrong, Boeing, Heiner, Bergmann, Manuela M., Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H. M., Weiderpass, Elisabete, Engeset, Dagrun, Braaten, Tonje, Redondo, Maria Luisa, Agudo, Antonio, Sánchez, María-José, Amiano, Pilar, Huerta, José-María, Ardanaz, Eva, Drake, Isabel, Sonestedt, Emily, Johansson, Ingegerd, Winkvist, Anna, Khaw, Kay-Tee, Wareham, Nick J., Key, Timothy J., Bradbury, Kathryn E., Johansson, Mattias, Licaj, Idlir, Gunter, Marc J., Murphy, Neil, Riboli, Elio, and Bueno-de-Mesquita, H. Bas

Published
2014

44. Dietary Polyphenols in the Aetiology of Crohnʼs Disease and Ulcerative Colitis—A Multicenter European Prospective Cohort Study (EPIC)

Author

Lu, Yunxia, Zamora-Ros, Raul, Chan, Simon, Cross, Amanda J., Ward, Heather, Jakszyn, Paula, Luben, Robert, Opstelten, Jorrit L., Oldenburg, Bas, Hallmans, Göran, Karling, Pontus, Grip, Olof, Key, Timothy, Bergmann, Manuela M., Boeing, Heiner, Overvad, Kim, Palli, Domenico, Masala, Giovanna, Khaw, Kay-Tee, Racine, Antoine, Carbonnel, Franck, Boutron-Ruault, Marie-Christine, Andersen, Vibeke, Olsen, Anja, Tjonneland, Anne, Kaaks, Rudolf, Tumino, Rosario, Trichopoulou, Antonia, Scalbert, Augustin, Riboli, Elio, and Hart, Andrew R.

Published
2017
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46. Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses

Author

Dimou, Niki, primary, Omiyale, Wemimo, additional, Biessy, Carine, additional, Viallon, Vivian, additional, Kaaks, Rudolf, additional, O'Mara, Tracy A., additional, Aglago, Elom K., additional, Ardanaz, Eva, additional, Bergmann, Manuela M., additional, Bondonno, Nicola P., additional, Braaten, Tonje, additional, Colorado-Yohar, Sandra M., additional, Crous-Bou, Marta, additional, Dahm, Christina C., additional, Fortner, Renée T., additional, Gram, Inger T., additional, Harlid, Sophia, additional, Heath, Alicia K., additional, Idahl, Annika, additional, Kvaskoff, Marina, additional, Nøst, Therese H., additional, Overvad, Kim, additional, Palli, Domenico, additional, Perez-Cornago, Aurora, additional, Sacerdote, Carlotta, additional, Sánchez, Maria-Jose, additional, Schulze, Matthias B., additional, Severi, Gianluca, additional, Simeon, Vittorio, additional, Tagliabue, Giovanna, additional, Tjønneland, Anne, additional, Truong, Thérèse, additional, Tumino, Rosario, additional, Johansson, Mattias, additional, Weiderpass, Elisabete, additional, Murphy, Neil, additional, Gunter, Marc J., additional, Lacey, Ben, additional, Allen, Naomi E., additional, and Dossus, Laure, additional

Published
2022
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48. Adherence to the World Cancer Research Fund/American Institute for Cancer Research guidelines and risk of death in Europe: results from the European Prospective Investigation into Nutrition and Cancer cohort study

Author

Vergnaud, Anne-Claire, Romaguera, Dora, Peeters, Petra H, van Gils, Carla H, Chan, Doris SM, Romieu, Isabelle, Freisling, Heinz, Ferrari, Pietro, Clavel-Chapelon, Françoise, Fagherazzi, Guy, Dartois, Laureen, Li, Kuanrong, Tikk, Kaja, Bergmann, Manuela M, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C, Redondo, Maria Luisa, Agudo, Antonio, Sánchez, María-José, Amiano, Pilar, Chirlaque, María-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nick J, Crowe, Francesca, Trichopoulou, Antonia, Orfanos, Philippos, Trichopoulos, Dimitrios, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Vineis, Paolo, Panico, Salvatore, Bueno-de-Mesquita, H Bas, Ros, Martine M, May, Anne, Wirfält, Elisabet, Sonestedt, Emily, Johansson, Ingegerd, Hallmans, Göran, Lund, Eiliv, Weiderpass, Elisabete, Parr, Christine L, Riboli, Elio, and Norat, Teresa

Published
2013
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49. Cigarette Smoking and Endometrial Cancer Risk : observational and Mendelian Randomization Analyses

Author

Dimou, Niki, Omiyale, Wemimo, Biessy, Carine, Viallon, Vivian, Kaaks, Rudolf, O'Mara, Tracy A., Aglago, Elom K., Ardanaz, Eva, Bergmann, Manuela M., Bondonno, Nicola P., Braaten, Tonje, Colorado-Yohar, Sandra M., Crous-Bou, Marta, Dahm, Christina C., Fortner, Renée T, Gram, Inger T., Harlid, Sophia, Heath, Alicia K., Idahl, Annika, Kvaskoff, Marina, Nøst, Therese H., Overvad, Kim, Palli, Domenico, Perez-Cornago, Aurora, Sacerdote, Carlotta, Sánchez, Maria-Jose, Schulze, Matthias B., Severi, Gianluca, Simeon, Vittorio, Tagliabue, Giovanna, Tjønneland, Anne, Truong, Thérèse, Tumino, Rosario, Johansson, Mattias, Weiderpass, Elisabete, Murphy, Neil, Gunter, Marc J., Lacey, Ben, Allen, Naomi E., Dossus, Laure, Dimou, Niki, Omiyale, Wemimo, Biessy, Carine, Viallon, Vivian, Kaaks, Rudolf, O'Mara, Tracy A., Aglago, Elom K., Ardanaz, Eva, Bergmann, Manuela M., Bondonno, Nicola P., Braaten, Tonje, Colorado-Yohar, Sandra M., Crous-Bou, Marta, Dahm, Christina C., Fortner, Renée T, Gram, Inger T., Harlid, Sophia, Heath, Alicia K., Idahl, Annika, Kvaskoff, Marina, Nøst, Therese H., Overvad, Kim, Palli, Domenico, Perez-Cornago, Aurora, Sacerdote, Carlotta, Sánchez, Maria-Jose, Schulze, Matthias B., Severi, Gianluca, Simeon, Vittorio, Tagliabue, Giovanna, Tjønneland, Anne, Truong, Thérèse, Tumino, Rosario, Johansson, Mattias, Weiderpass, Elisabete, Murphy, Neil, Gunter, Marc J., Lacey, Ben, Allen, Naomi E., and Dossus, Laure

Abstract

BACKGROUND: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. METHODS: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. RESULTS: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. CONCLUSIONS: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. IMPACT: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.

Published
2022
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50. Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma

Author

Stepien, Magdalena, Lopez-Nogueroles, Marina, Lahoz, Agustin, Kühn, Tilman, Perlemuter, Gabriel, Voican, Cosmin, Ciocan, Dragos, Boutron-Ruault, Marie-Christine, Jansen, Eugene, Viallon, Vivian, Leitzmann, Michael, Tjønneland, Anne, Severi, Gianluca, Mancini, Francesca Romana, Dong, Catherine, Kaaks, Rudolf, Fortner, Renee Turzanski, Bergmann, Manuela M., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Skeie, Guri, Merino, Susana, Ros, Raul Zamora, Sánchez, Maria Jose, Amiano, Pilar, Huerta, Jose Mª, Barricarte, Aurelio, Sjöberg, Klas, Ohlsson, Bodil, Nyström, Hanna, Werner, Mårten, Perez-Cornago, Aurora, Schmidt, Julie A., Freisling, Heinz, Scalbert, Augustin, Weiderpass, Elisabete, Christakoudi, Sofia, Gunter, Marc J., Jenab, Mazda, Stepien, Magdalena, Lopez-Nogueroles, Marina, Lahoz, Agustin, Kühn, Tilman, Perlemuter, Gabriel, Voican, Cosmin, Ciocan, Dragos, Boutron-Ruault, Marie-Christine, Jansen, Eugene, Viallon, Vivian, Leitzmann, Michael, Tjønneland, Anne, Severi, Gianluca, Mancini, Francesca Romana, Dong, Catherine, Kaaks, Rudolf, Fortner, Renee Turzanski, Bergmann, Manuela M., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, H. Bas, Skeie, Guri, Merino, Susana, Ros, Raul Zamora, Sánchez, Maria Jose, Amiano, Pilar, Huerta, Jose Mª, Barricarte, Aurelio, Sjöberg, Klas, Ohlsson, Bodil, Nyström, Hanna, Werner, Mårten, Perez-Cornago, Aurora, Schmidt, Julie A., Freisling, Heinz, Scalbert, Augustin, Weiderpass, Elisabete, Christakoudi, Sofia, Gunter, Marc J., and Jenab, Mazda

Abstract

Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of carcinogenic BAs. Observations from prospective cohorts are sparse. We conducted a study (233 HCC case-control pairs) nested within a large observational prospective cohort with blood samples taken at recruitment when healthy with follow-up over time for later cancer development. A targeted metabolomics method was used to quantify 17 BAs (primary/secondary/tertiary; conjugated/unconjugated) in prediagnostic plasma. Odd ratios (OR) for HCC risk associations were calculated by multivariable conditional logistic regression models. Positive HCC risk associations were observed for the molar sum of all BAs (ORdoubling = 2.30, 95% confidence intervals [CI]: 1.76-3.00), and choline- and taurine-conjugated BAs. Relative concentrations of BAs showed positive HCC risk associations for glycoholic acid and most taurine-conjugated BAs. We observe an association between increased HCC risk and higher levels of major circulating BAs, from several years prior to tumor diagnosis and after multivariable adjustment for confounders and liver functionality. Increase in BA concentration is accompanied by a shift in BA profile toward higher proportions of taurine-conjugated BAs, indicating early alterations of BA metabolism with HCC development. Future studies are needed to assess BA profiles for improved stratification of patients at high HCC risk and to determine whether supplementation with certain BAs may ameliorate liver dysfunction.

Published
2022
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