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1. Biogeochemical and community ecology responses to the wetting of non-perennial streams

Author

Price, Adam Nicholas, Zimmer, Margaret Ann, Bergstrom, Anna, Burgin, Amy Jo, Seybold, Erin Cedar, Krabbenhoft, Corey Anne, Zipper, Sam, Busch, Michelle Hope, Dodds, Walter Kennedy, Walters, Annika, Rogosch, Jane Sarah, Stubbington, Rachel, Walker, Richard Harry, Stegen, James Christian, Datry, Thibault, Messager, Mathis, Olden, Julian, Godsey, Sarah Elizabeth, Shanafield, Margaret, Lytle, David, Burrows, Ryan, Kaiser, Kendra Elena, Allen, George Henry, Mims, Meryl Christine, Tonkin, Jonathan Douglas, Bogan, Michael, Hammond, John Christopher, Boersma, Kate, Myers-Pigg, Allison Nicole, DelVecchia, Amanda, Allen, Daniel, Yu, Songyan, and Ward, Adam

Published
2024
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2. Clinical implications of airway obstruction with normal or low FEV 1 in childhood and adolescence.

Author

Koefoed, Hans Jacob Lohne, Wang, Gang, Gehring, Ulrike, Ekstrom, Sandra, Kull, Inger, Vermeulen, Roel, Boer, Jolanda M A, Bergstrom, Anna, Koppelman, Gerard H, Melén, Erik, Vonk, Judith M, Hallberg, Jenny, Koefoed, Hans Jacob Lohne, Wang, Gang, Gehring, Ulrike, Ekstrom, Sandra, Kull, Inger, Vermeulen, Roel, Boer, Jolanda M A, Bergstrom, Anna, Koppelman, Gerard H, Melén, Erik, Vonk, Judith M, and Hallberg, Jenny

Abstract

Background: Airway obstruction is defined by spirometry as a low forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio. This impaired ratio may originate from a low FEV1 (classic) or a normal FEV1 in combination with a large FVC (dysanaptic). The clinical implications of dysanaptic obstruction during childhood and adolescence in the general population remain unclear. Aims: To investigate the association between airway obstruction with a low or normal FEV1 in childhood and adolescence, and asthma, wheezing and bronchial hyperresponsiveness (BHR). Methods: In the BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology; Sweden) and PIAMA (Prevention and Incidence of Asthma and Mite Allergy; the Netherlands) birth cohorts, obstruction (FEV1:FVC ratio less than the lower limit of normal, LLN) at ages 8, 12 (PIAMA only) or 16 years was classified as classic (FEV1

Published
2024

3. Clinical implications of airway obstruction with normal or low FEV 1 in childhood and adolescence

Author

Onderzoeksgroep 10, Planetary Health & Exposoom, Cancer, Circulatory Health, Koefoed, Hans Jacob Lohne, Wang, Gang, Gehring, Ulrike, Ekstrom, Sandra, Kull, Inger, Vermeulen, Roel, Boer, Jolanda M.A., Bergstrom, Anna, Koppelman, Gerard H., Melén, Erik, Vonk, Judith M., Hallberg, Jenny, Onderzoeksgroep 10, Planetary Health & Exposoom, Cancer, Circulatory Health, Koefoed, Hans Jacob Lohne, Wang, Gang, Gehring, Ulrike, Ekstrom, Sandra, Kull, Inger, Vermeulen, Roel, Boer, Jolanda M.A., Bergstrom, Anna, Koppelman, Gerard H., Melén, Erik, Vonk, Judith M., and Hallberg, Jenny

Published
2024

4. Natural course of pollen-induced allergic rhinitis from childhood to adulthood : A 20-year follow up

Author

Lindqvist, Magnus, Leth-Moller, Katja Biering, Linneberg, Allan, Kull, Inger, Bergstrom, Anna, Georgellis, Antonios, Borres, Magnus P., Ekebom, Agneta, van Hage, Marianne, Melen, Erik, Westman, Marit, Lindqvist, Magnus, Leth-Moller, Katja Biering, Linneberg, Allan, Kull, Inger, Bergstrom, Anna, Georgellis, Antonios, Borres, Magnus P., Ekebom, Agneta, van Hage, Marianne, Melen, Erik, and Westman, Marit

Abstract

Background: Allergic rhinitis (AR) is one of the most common chronic diseases worldwide. There are limited prospective long-term data regarding persistency and remission of AR. The objective of this study was to investigate the natural course of pollen-induced AR (pollen-AR) over 20 years, from childhood into early adulthood. Methods: Data from 1137 subjects in the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic birth cohort (BAMSE) with a completed questionnaire regarding symptoms, asthma, treatment with allergen immunotherapy (AIT) and results of allergen-specific IgE for inhalant allergens at 4, 8, 16 and 24 years were analyzed. Pollen-AR was defined as sneezing, runny, itchy or blocked nose; and itchy or watery eyes when exposed to birch and/or grass pollen in combination with allergen-specific IgE >= 0.35kUA/L to birch and/or grass. Results: Approximately 75% of children with pollen-AR at 4 or 8 years had persistent disease up to 24 years, and 30% developed asthma. The probability of persistency was high already at low levels of pollen-specific IgE. The highest rate of remission from pollen-AR was seen between 16 and 24 years (21.5%); however, the majority remained sensitized. This period was also when pollen-specific IgE-levels stopped increasing and the average estimated annual incidence of pollen-AR decreased from 1.5% to 0.8% per year. Conclusion: Children with pollen-AR are at high risk of persistent disease for at least 20 years. Childhood up to adolescence seems to be the most dynamic period of AR progression. Our findings underline the close cross-sectional and longitudinal relationship between sensitization, AR and asthma.

Published
2024
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5. Clinical implications of airway obstruction with normal or low FEV 1 in childhood and adolescence.

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Koefoed, Hans Jacob Lohne, Wang, Gang, Gehring, Ulrike, Ekstrom, Sandra, Kull, Inger, Vermeulen, Roel, Boer, Jolanda M A, Bergstrom, Anna, Koppelman, Gerard H, Melén, Erik, Vonk, Judith M, Hallberg, Jenny, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Koefoed, Hans Jacob Lohne, Wang, Gang, Gehring, Ulrike, Ekstrom, Sandra, Kull, Inger, Vermeulen, Roel, Boer, Jolanda M A, Bergstrom, Anna, Koppelman, Gerard H, Melén, Erik, Vonk, Judith M, and Hallberg, Jenny

Published
2024

6. The hydrologic and geochemical contributions from snow to streamflow in the McMurdo Dry Valleys of Antarctica.

Author

Wright, Anna, Gooseff, Michael, Bergstrom, Anna, and Welch, Kathleen

Subjects
RIVER channels, WATERSHEDS, VALLEYS, ALGAL growth, REMOTE-sensing images
Abstract

The glacial meltwater streams in the McMurdo Dry Valleys (MDVs), Antarctica only flow during the austral summer and contain abundant algal mats which grow at the onset of flow. Their relative abundance in stream channels of this polar desert make the streams biogeochemical hot spots. The MDVs receive minimal precipitation as snow, which is redistributed by wind and deposited in distinct locations, some of which become persistent snow patches each year. Previous studies identified that MDV streamflow comes from a combination of glacier ice and snow, although snow was assumed to contribute little to the overall water budget. This study uses a combination of satellite imagery, terrain analysis, and field measurements to determine where snow patches accumulate and persist across MDV watersheds, and to quantify the potential hydrologic and biogeochemical contributions of snow patches to streams. Watersheds near the coast have the highest snow‐covered area and longest snow persistence. Many of these snow patches accumulate within the stream channels, which results in the potential to contribute to streamflow. During the summer of 2021–2022, stream channel snow patches had the potential to contribute anywhere between <1% and 90% of the total annual discharge in Lake Fryxell Basin streams, and may increase with different hydrometeorological conditions. On average the potential inputs from snow patches to streamflow was between 12% and 25% of the annual discharge during the 2021–2022 season, as determined by snow area and SWE. Snow patches in the majority of the watersheds had higher nitrogen and phosphorous concentrations than stream water, and six streams contained snow with higher N:P ratios than the average N:P in the stream water. This suggests that if such patches melt early in the summer, these nutrient and water inputs could occur at the right time and stoichiometry to be crucial for early season algal mat growth. [ABSTRACT FROM AUTHOR]

Published
2024
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8. How low can you go? Widespread challenges in measuring low stream discharge and a path forward

Author

Seybold, Erin C., primary, Bergstrom, Anna, additional, Jones, C. Nathan, additional, Burgin, Amy J., additional, Zipper, Sam, additional, Godsey, Sarah E., additional, Dodds, Walter K., additional, Zimmer, Margaret A., additional, Shanafield, Margaret, additional, Datry, Thibault, additional, Mazor, Raphael D., additional, Messager, Mathis L., additional, Olden, Julian D., additional, Ward, Adam, additional, Yu, Songyan, additional, Kaiser, Kendra E., additional, Shogren, Arial, additional, and Walker, Richard H., additional

Published
2023
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9. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author

Anto, Josep M., Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S., Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N., Lodrup Carlsen, Karin C., Koppelman, Gerard H., Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L., Maier, Dieter, Melén, Erik, Smit, Henriette A., Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M., Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C., Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J., Siroux, Valerie, Tischer, Christina G., Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian

Published
2017
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10. Stillbirths: rates, risk factors, and acceleration towards 2030

Author

Flenady, Vicki, Frøen, J Frederik, Kinney, Mary V, de Bernis, Luc, Lawn, Joy E, Blencowe, Hannah, Heazell, Alexander, Leisher, Susannah Hopkins, Azad, Kishwar, Rahman, Anisur, El-Arifeen, Shams, Day, Louise T, Shah, Stacy L, Alam, Shafi, Wangdi, Sonam, Ilboudo, Tinga Fulbert, Zhu, Jun, Liang, Juan, Mu, Yi, Li, Xiaohong, Zhong, Nanbert, Kyprianou, Theopisti, Allvee, Kärt, Gissler, Mika, Zeitlin, Jennifer, Bah, Abdouli, Jawara, Lamin, Waiswa, Peter, Lack, Nicholas, de Maria Herandez, Flor, Shah More, Neena, Nair, Nirmala, Tripathy, Prasanta, Kumar, Rajesh, Newtonraj, Ariarathinam, Kaur, Manmeet, Gupta, Madhu, Varghese, Beena, Isakova, Jelena, Phiri, Tambosi, Hall, Jennifer A, Curteanu, Ala, Manandhar, Dharma, Hukkelhoven, Chantal, Dijs-Elsinga, Joyce, Klungsøyr, Kari, Poppe, Olva, Barros, Henrique, Correia, Sofi, Tsiklauri, Shorena, Cap, Jan, Podmanicka, Zuzana, Szamotulska, Katarzyna, Pattison, Robert, Hassan, Ahmed Ali, Musafi, Aimable, Kujala, Sanni, Bergstrom, Anna, Langhoff -Roos, Jens, Lundqvist, Ellen, Kadobera, Daniel, Costello, Anthony, Colbourn, Tim, Fottrell, Edward, Prost, Audrey, Osrin, David, King, Carina, Neuman, Melissa, Hirst, Jane, Rubayet, Sayed, Smith, Lucy, Manktelow, Bradley N, Draper, Elizabeth S, Amouzou, Agbessi, Mathers, Colin, Hogan, Dan, Qureshi, Zeshan U, Calderwood, Claire, Shiekh, Suhail, Jassir, Fiorella Bianchi, You, Danzhen, McClure, Elizabeth M, Mathai, Matthews, and Cousens, Simon

Published
2016
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11. National, regional, and worldwide estimates of stillbirth rates in 2015, with trends from 2000: a systematic analysis

Author

Zhu, Jun, Liang, Juan, Mu, Yi, Li, Xiaohong, Costello, Anthony, Colbourn, Tim, Fottrell, Edward, Prost, Audrey, Osrin, David, King, Carina, Neuman, Melissa, More, Neena Shah, Azad, Kishwar, Manandhar, Dharma, Nair, Nirmala, Tripathy, Prasanta, Kumar, Rajesh, Newtonraj, Ariarathinam, Kaur, Manmeet, Gupta, Madhu, Dhaliwal, LK, Aggarwal, Neelam, Venkateshashan, Chawla, Deepak, Hurja, Anju, Shivkumar, Poonam, Jain, Manish, Gathwala, Geeta, Nanda, Smiti, Gupta, Shashi, Singal, Sangeeta, Kumar, Raj, Sharma, Sujata, Mohi, Manjit, Minhas, Santish, Prasad, Rajendra, Verma, Suresh, Raina, Neena, Li, Aimable Musafi, Varghese, Beena, Pattison, Robert, Hirst, Jane, Waiswa, Peter, Kadobera, Daniel, Kujala, Sanni, Bergstrom, Anna, Phiri, Tambosi, Hall, Jennifer A, Day, Louise T, Saha, Stacy L, Alam, Shafi Ul, Rahman, Anisur, El-Arifeen, Shams, Rubayet, Sayed, Hassan, Ahmed Ali, Smith, Lucy, Manktelow, Bradley N, Draper, Elizabeth S, Zhong, Nanbert, Langhoff-Roos, Jans, Flenady, Vicki, Allvee, Kärt, Gissler, Mika, Lack, Nicholas, Wangdi, Sonam, Cap, Jan, Podmanicka, Zuzana, Szamotulska, Katarzyna, Hukkelhoven, Chantal, Dijs-Elsinga, Joyce, Kyprianou, Theopisti, Klungsøyr, Kari, Herandez, Flor de Maria, Curteanu, Ala, Barros, Henrique, Correia, Sofia, Tsiklauri, Shorena, Lundqvist, Ellen, Fulbert Ilboudo, Tinga, Bah, Abdouli, Jawara, Lamin, Zeitlin, Jennifer, Isakova, Jelena, Poppe, Olav, Blencowe, Hannah, Cousens, Simon, Jassir, Fiorella Bianchi, Say, Lale, Chou, Doris, Mathers, Colin, Hogan, Dan, Shiekh, Suhail, Qureshi, Zeshan U, You, Danzhen, and Lawn, Joy E

Published
2016
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12. Clinical implications of airway obstruction with normal or low FEV1in childhood and adolescence

Author

Koefoed, Hans Jacob Lohne, Wang, Gang, Gehring, Ulrike, Ekstrom, Sandra, Kull, Inger, Vermeulen, Roel, Boer, Jolanda M A, Bergstrom, Anna, Koppelman, Gerard H, Melén, Erik, Vonk, Judith M, and Hallberg, Jenny

Abstract

BackgroundAirway obstruction is defined by spirometry as a low forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio. This impaired ratio may originate from a low FEV1(classic) or a normal FEV1in combination with a large FVC (dysanaptic). The clinical implications of dysanaptic obstruction during childhood and adolescence in the general population remain unclear.AimsTo investigate the association between airway obstruction with a low or normal FEV1in childhood and adolescence, and asthma, wheezing and bronchial hyperresponsiveness (BHR).MethodsIn the BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology; Sweden) and PIAMA (Prevention and Incidence of Asthma and Mite Allergy; the Netherlands) birth cohorts, obstruction (FEV1:FVC ratio less than the lower limit of normal, LLN) at ages 8, 12 (PIAMA only) or 16 years was classified as classic (FEV1

Published
2024
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13. Plasticity of Individual Lung Function States from Childhood to Adulthood

Author

Wang, Gang, Hallberg, Jenny, Faner, Rosa, Koefoed, Hans Jacob, Merid, Simon Kebede, Klevebro, Susanna, Bjorkander, Sophia, Gruzieva, Olena, Pershagen, Goran, van Hage, Marianne, Guerra, Stefano, Bottai, Matteo, Georgelis, Antonios, Gehring, Ulrike, Bergstrom, Anna, Vonk, Judith M., Kull, Inger, Koppelman, Gerard H., Agusti, Alvar, Melen, Erik, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
respiratory health, inflammation, multiple-breath washout, early life risk factors, asthma
Abstract

Rationale: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life. Objectives: To explore the plasticity of individual lung function states during childhood. Methods: Prebronchodilator FEV1 z-scores determined at age 8, 16, and 24 years in the Swedish population-based birth cohort BAMSE (Swedish abbreviation for Child [Barn], Allergy, Milieu, Stockholm, Epidemiological study) (N = 3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low or very low states to normal or high or very high states, and growth failure as moving from normal or high or very high states to low or very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA (Prevention and Incidence of Asthma and Mite Allergy) cohort. Measurements and Main Results: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low or very low states and 36 (2.4%) participants with normal or high or very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified IL-6 and CXCL10 (C-X-C motif chemokine 10) as potential biomarkers of impaired lung function development. Conclusions: Individual lung function states during childhood are plastic, including catch-up and growth failure.

Published
2023

14. Alpha-gal sensitization among young adults is associated with male sex and polysensitization

Author

Westman, Marit, Asarnoj, Anna, Ballardini, Natalia, Andersson, Niklas, Kiewiet, M. B. Gea, Borres, Magnus P, Apostolovic, Danijela, Kull, Inger, Bergstrom, Anna, Melen, Erik, Van Hage, Marianne, Westman, Marit, Asarnoj, Anna, Ballardini, Natalia, Andersson, Niklas, Kiewiet, M. B. Gea, Borres, Magnus P, Apostolovic, Danijela, Kull, Inger, Bergstrom, Anna, Melen, Erik, and Van Hage, Marianne

Published
2022
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15. Spirometric phenotypes from early childhood to young adulthood:a Chronic Airway Disease Early Stratification study

Author

Wang, Gang, Hallberg, Jenny, Charalampopoulos, Dimitrios, Sanahuja, Maribel Casas, Breyer-Kohansal, Robab, Langhammer, Arnulf, Granell, Raquel, Vonk, Judith M., Mian, Annemiek, Olvera, Nuria, Laustsen, Lisbeth Molgaard, Ronmark, Eva, Abellan, Alicia, Agusti, Alvar, Arshad, Syed Hasan, Bergstrom, Anna, Boezen, H. Marike, Breyer, Marie-Kathrin, Burghuber, Otto, Bolund, Anneli Clea, Custovic, Adnan, Devereux, Graham, Donaldson, Gavin C., Duijts, Liesbeth, Esplugues, Ana, Faner, Rosa, Ballester, Ferran, Garcia-Aymerich, Judith, Gehring, Ulrike, SadiaHaider, Hartl, Sylvia, HelenaBackman, Holloway, John W., Koppelman, Gerard H., Lertxundi, Aitana, Holmen, Turid Lingaas, Lowe, Lesley, Mensink-Bout, Sara M., Murray, Clare S., Roberts, Graham, Hedman, Linnea, Schlunssen, Vivi, Sigsgaard, Torben, Simpson, Angela, Sunyer, Jordi, Torrent, Maties, Turner, Stephen, Van den Berge, Maarten, Vermeulen, Roel C. H., Vikjord, Sigrid Anna Aalberg, Pediatrics, Erasmus MC other, Groningen Research Institute for Asthma and COPD (GRIAC), and Life Course Epidemiology (LCE)

Subjects
LUNG-FUNCTION, NATIONAL-HEALTH, PREGNANCY, BIRTH, MORTALITY, ASTHMA, GROWTH, MATERNAL SMOKING, IMPAIRMENT, POPULATION
Abstract

Background The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. Methods We studied 49334 participants from 14 population-based cohorts in different age groups (⩽10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV 1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV 1/FVC z-score ⩾LLN, and FVC z-score −2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46). Conclusion Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.

Published
2021

16. Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

Author

Wang, Gang, Hallberg, Jenny, Charalampopoulos, Dimitrios, Sanahuja, Maribel Casas, Breyer-Kohansal, Robab, Langhammer, Arnulf, Granell, Raquel, Vonk, Judith M, Mian, Annemiek, Olvera, Nuria, Laustsen, Lisbeth Molgaard, Ronmark, Eva, Abellan, Alicia, Agusti, Alvar, Arshad, Syed Hasan, Bergstrom, Anna, Boezen, H Marike, Breyer, Marie-Kathrin, Burghuber, Otto, Bolund, Anneli Clea, Custovic, Adnan, Devereux, Graham, Donaldson, Gavin C, Duijts, Liesbeth, Esplugues, Ana, Faner, Rosa, Ballester, Ferran, Garcia-Aymerich, Judith, Gehring, Ulrike, Haider, Sadia, Hartl, Sylvia, Backman, Helena, Holloway, John W, Koppelman, Gerard H, Lertxundi, Aitana, Holmen, Turid Lingaas, Lowe, Lesley, Mensink-Bout, Sara M, Murray, Clare S, Roberts, Graham, Hedman, Linnea, Schlunssen, Vivi, Sigsgaard, Torben, Simpson, Angela, Sunyer, Jordi, Torrent, Maties, Turner, Stephen, Van den Berge, Maarten, Vermeulen, Roel CH, Vikjord, Sigrid Anna Aalberg, Wedzicha, Jadwiga A, van der Zee, Anke H Maitland, Melen, Erik, and Collaboration, CADSET Clinical Res

Published
2021

17. Plasticity of Individual Lung Function States from Childhood to Adulthood.

Author

Gang Wang, Hallberg, Jenny, Faner, Rosa, Koefoed, Hans-Jacob, Merid, Simon Kebede, Klevebro, Susanna, Bjorkander, Sophia, Gruzieva, Olena, Pershagen, Goran, Hage, Marianne van, Guerra, Stefano, Bottai, Matteo, Georgelis, Antonios, Gehring, Ulrike, Bergstrom, Anna, Vonk, Judith M., Kull, Inger, Koppelman, Gerard H., Agusti, Alvar, and Melen, Erik

Subjects
LUNGS, LUNG development, ADULTS, CHILD development, CHEMOKINES
Abstract

Rationale: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life.Objectives: To explore the plasticity of individual lung function states during childhood.Methods: Pre-bronchodilator FEV1 z-scores determined at age 8, 16 and 24 years in the Swedish population-based birth cohort BAMSE (N=3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low/very low states to normal/high/very high states, and growth failure as moving from normal/high/very high states to low/very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA cohort.Measurements and Main Results: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low/very low states and 36 (2.4%) participants with normal/high/very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified Interleukin-6 and C-X-C motif chemokine 10 as potential biomarkers of impaired lung function development.Conclusions: Individual lung function states during childhood are plastic, including catch-up and growth failure. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). [ABSTRACT FROM AUTHOR]

Published
2023
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18. Acquisition of Tense and Aspect in Second Language and Foreign Language Learning: Learner Narratives in ESL and FFL.

Author

Bardovi-Harlig, Kathleen and Bergstrom, Anna

Abstract

Investigates the acquisition of tense and aspect by learners of English as a Second Language and learners of French as a Foreign Language. Examination of written narratives collected from both groups using a film retell task reveals similar patterns of distribution of tense/aspect morphology across target languages. (29 references) (Author/CK)

Published
1996

22. Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure

Author

Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Merid, Simon Kebede, Bustamante, Mariona, Standl, Marie, Sunyer, Jordi, Heinrich, Joachim, Lemonnier, Nathanael, Aguilar, Daniel, Antó, Josep Maria, Bousquet, Jean, Santa Marina, Loreto, Lertxundi Manterola, Aitana, Bergstrom, Anna, Kull, Inger, Wheelock, Asa M., Koppelman, Gerard H., Melen, Erik, Gruzieva, Olena, Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, Merid, Simon Kebede, Bustamante, Mariona, Standl, Marie, Sunyer, Jordi, Heinrich, Joachim, Lemonnier, Nathanael, Aguilar, Daniel, Antó, Josep Maria, Bousquet, Jean, Santa Marina, Loreto, Lertxundi Manterola, Aitana, Bergstrom, Anna, Kull, Inger, Wheelock, Asa M., Koppelman, Gerard H., Melen, Erik, and Gruzieva, Olena

Abstract

Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this meta-analysis of transcriptome-wide association studies of 656 children and adolescents from three European cohorts participating in the MeDALL Consortium, we found two differentially expressed transcript clusters (FDR p < 0.05) associated with exposure to particulate matter < 2.5 mu m in diameter (PM2.5) at birth, one of them mapping to the MIR1296 gene. Further, by integrating gene expression with DNA methylation using Functional Epigenetic Modules algorithms, we identified 9 and 6 modules in relation to PM2.5 exposure at birth and at current address, respectively (including NR1I2, MAPK6, TAF8 and SCARA3). In conclusion, PM2.5 exposure at birth was linked to differential gene expression in children and adolescents. Importantly, we identified several significant interactome hotspots of gene modules of relevance for complex diseases in relation to PM2.5 exposure.

Published
2021

23. Scoring the Risk of Having Systemic Mastocytosis in Adult Patients with Mastocytosis in the Skin

Author

Fuchs, David, Kilbertus, Alex, Kofler, Karin, von Bubnoff, Nikolas, Shoumariyeh, Khalid, Zanotti, Roberta, Bonadonna, Patrizia, Scaffidi, Luigi, Doubek, Michael, Elberink, Hanneke Oude, Span, Lambert F. R., Hermine, Olivier, Elena, Chiara, Benvenuti, Pietro, Yavuz, Akif Selim, Brockow, Knut, Zink, Alexander, Aberer, Elisabeth, Gorska, Aleksandra, Romantowski, Jan, Hadzijusufovic, Emir, Fortina, Anna Belloni, Caroppo, Francesca, Perkins, Cecelia, Illerhaus, Anja, Panse, Jens, Vucinic, Vladan, Jawhar, Mohamad, Sabato, Vito, Triggiani, Massimo, Parente, Roberta, Bergstrom, Anna, Breynaert, Christine, Gotlib, Jason, Reiter, Andreas, Hartmann, Karin, Niedoszytko, Marek, Arock, Michel, Kluin-Nelemans, Hanneke C., Sperr, Wolfgang R., Greul, Rosemarie, Valent, Peter, Fuchs, David, Kilbertus, Alex, Kofler, Karin, von Bubnoff, Nikolas, Shoumariyeh, Khalid, Zanotti, Roberta, Bonadonna, Patrizia, Scaffidi, Luigi, Doubek, Michael, Elberink, Hanneke Oude, Span, Lambert F. R., Hermine, Olivier, Elena, Chiara, Benvenuti, Pietro, Yavuz, Akif Selim, Brockow, Knut, Zink, Alexander, Aberer, Elisabeth, Gorska, Aleksandra, Romantowski, Jan, Hadzijusufovic, Emir, Fortina, Anna Belloni, Caroppo, Francesca, Perkins, Cecelia, Illerhaus, Anja, Panse, Jens, Vucinic, Vladan, Jawhar, Mohamad, Sabato, Vito, Triggiani, Massimo, Parente, Roberta, Bergstrom, Anna, Breynaert, Christine, Gotlib, Jason, Reiter, Andreas, Hartmann, Karin, Niedoszytko, Marek, Arock, Michel, Kluin-Nelemans, Hanneke C., Sperr, Wolfgang R., Greul, Rosemarie, and Valent, Peter

Abstract

BACKGROUND: Mastocytosis in adults often presents with skin lesions. A bone marrow biopsy is necessary to confirm or exclude the presence of systemic mastocytosis (SM) in these cases. When a bone marrow biopsy is not performed, the provisional diagnosis is mastocytosis in the skin (MIS). No generally accepted scoring system has been established to estimate the risk of SM in these patients. OBJECTIVE: To develop a risk score to predict SM in adults with MIS. METHODS: We examined 1145 patients with MIS from the European Competence Network on Mastocytosis Registry who underwent a bone marrow biopsy. A total of 944 patients had SM and 201 patients had cutaneous mastocytosis; 63.7% were female, and 36.3% were male. Median age was 44 +/- 13.3 years. The median serum tryptase level amounted to 29.3 +/- 81.9 ng/mL. We established a multivariate regression model using the whole population of patients as a training and validation set (bootstrapping). A risk score was developed and validated with receiver-operating curves. RESULTS: In the multivariate model, the tryptase level (P < .001), constitutional/cardiovascular symptoms (P = .014), and bone symptoms/osteoporosis (P < .001) were independent predictors of SM (P < .001; sensitivity, 90.7%; specificity, 69.1%). A 6-point risk score was established (risk, 10.7%-98.0%) and validated. CONCLUSIONS: Using a large data set of the European Competence Network on Mastocytosis Registry, we created a risk score to predict the presence of SM in patients with MIS. Although the score will need further validation in independent cohorts, our score seems to discriminate safely between patients with SM and with pure cutaneous mastocytosis. (C) 2020 American Academy of Allergy, Asthma & Immunology

Published
2021

24. Prevalence and early-life risk factors for tree nut sensitization and allergy in young adults

Author

Bager, Jessica, Tedner, Sandra G., Andersson, Niklas, Ballardini, Natalia, Borres, Magnus P, Konradsen, Jon R., Nilsson, Caroline, Westman, Marit, Kull, Inger, Bergstrom, Anna, van Hage, Marianne, Melen, Erik, Asarnoj, Anna, Bager, Jessica, Tedner, Sandra G., Andersson, Niklas, Ballardini, Natalia, Borres, Magnus P, Konradsen, Jon R., Nilsson, Caroline, Westman, Marit, Kull, Inger, Bergstrom, Anna, van Hage, Marianne, Melen, Erik, and Asarnoj, Anna

Abstract

Background Tree nut allergy may cause anaphylaxis. There are limited population-based studies on prevalence and early-life risk factors. Methods We evaluated the prevalence of reported symptoms and allergic sensitization to tree nuts at age 24 years in the BAMSE population-based cohort study and assessed early-life factors associated with the development of tree nut allergy. We estimated tree nut allergy prevalence, by analysing questionnaire data on tree nut ingestion and symptoms at age 12, 16 and 24 years, and IgE sensitization at age 24 years to hazelnut, walnut, pecan, cashew, pistachio, Brazil nut, almond extracts and allergen molecules Cor a 1, 9, 14 (hazelnut), Jug r 1 (walnut) and Ana o 3 (cashew). We evaluated eczema, asthma, food allergies, inherited risk of allergy and gender as potential early-life risk factors. Results Data were available for 2215/4089 (54%) BAMSE study participants, for estimation of the prevalence of tree nut sensitization (21.2%), tree nut allergy symptoms (9.8%) and combined sensitization and symptoms (7.9%, 2.1% for storage protein sensitization and symptoms, 4.3% for any sensitization and non-mild symptoms). Sixty-three per cent of sensitized individuals (295/470) were asymptomatic, but only 76/470 (16%) storage protein sensitized individuals. Egg allergy (ORadj 8.50 95% CI 2.15-33.6), eczema (ORadj 2.53 95% CI 1.21-5.32) and asthma (ORadj 5.59 95% CI 2.35-13.3)) at pre-school age were associated with future development of tree nut symptoms and storage protein sensitization. At age 24 years, tree nut allergy was associated with current eczema and with markers of current asthma severity. Sensitization to storage proteins was more strongly associated with symptoms than sensitization to whole extract for all tree nuts evaluated. Conclusions In this Swedish cohort, we found tree nut whole extract sensitization is common but usually asymptomatic. Storage protein sensitization is a more reliable indicator of tree nut symptoms. Tree nut

Published
2021
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25. Resolved allergen-specific IgE sensitization among females and early poly-sensitization among males impact IgE sensitization up to age 24 years

Author

Ballardini, Natalia, Bergstrom, Anna, Kull, Inger, Almqvist, Catarina, Andersson, Niklas, Asarnoj, Anna, Borres, Magnus P, Georgellis, Antonis, Pershagen, Goran, Westman, Marit, van Hage, Marianne, Melen, Erik, Ballardini, Natalia, Bergstrom, Anna, Kull, Inger, Almqvist, Catarina, Andersson, Niklas, Asarnoj, Anna, Borres, Magnus P, Georgellis, Antonis, Pershagen, Goran, Westman, Marit, van Hage, Marianne, and Melen, Erik

Published
2021
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26. European birth cohorts for environmental health research

Author

Vrijheid, Martine, Casas, Maribel, Bergstrom, Anna, Carmichael, Amanda, Cordier, Sylvaine, Eggesbo, Merete, Eller, Esben, Fantini, Maria P., Fernandez, Mariana F., Fernandez-Somoano, Ana, Gehring, Ulrike, Grazuleviciene, Regina, Hohmann, Cynthia, Karvonen, Anne M., Keil, Thomas, Kogevinas, Manolis, Koppen, Gudrun, Kramer, Ursula, Kuehni, Claudia E., Magnus, Per, Majewska, Renata, Andersen, Anne-Marie Nybo, Patelarou, Evridiki, Petersen, Maria Skaalum, Pierik, FrankH., Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Santos, Ana Cristina, Slama, Remy, Sram, Radim J., Thijs, Carel, Tischer, Christina, Toft, Gunnar, Trnovec, Tomas, Vandentorren, Stephanie, Vrijkotte, Tanja G.M., Wilhelm, Michael, Wright, John, and Nieuwenhuijsen, Mark

Subjects
Environmental health -- Surveys -- Research, Pregnancy -- Surveys -- Research, Environmental issues, Health
Abstract

BACKGROUND: Many pregnancy and birth cohort studies investigate the health effects of early-life environmental contaminant exposure. An overview of existing studies and their data is needed to improve collaboration, harmonization, [...]

Published
2012

27. Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection

Author

Rosenlund, Helen, Bergstrom, Anna, Alm, Johan S., Swartz, Jackie, Scheynius, Annika, van Hage, Marianne, Johansen, Kari, Brunekreef, Bert, Mutius, Erika von, Ege, Markus J., Riedler, Josef, Braun-Fahrlander, Charlotte, Waser, Marco, and Pershagen, Goran

Subjects
Allergic reaction -- Development and progression, Allergic reaction -- Research, Allergic reaction -- Health aspects, Allergy -- Development and progression, Allergy -- Research, Allergy -- Health aspects, Measles vaccine -- Research, Measles vaccine -- Health aspects, Measles -- Research, Measles -- Health aspects, Children -- Diseases, Children -- Development and progression, Children -- Research, Children -- Health aspects
Published
2009

28. Standard operating procedure for Sample Exchange on a pan-European level to be used in the HBM4EU initiative incl. annexes

Author

Lermen, Dominik, Åkesson, Agneta, Bartel-Steinbach, Martina, Berglund, Marika, Bergstrom, Anna, Castaño Calvo, Argelia, Esteban López, Marta, Gwinner, Frederik, Horvat, Milena, Leander, Karin, Müller, Sabine, and Tratnik, Janja

Subjects
HBM4EU, HBM study, exchange, study material, Human Biomonitoring, standard, shipment, samples, transfer, HBM, SOP
Abstract

This Standard Operation Procedure (SOP) on Shipment comprises a strategy developed under HBM4EU containsa definition of basic technical, legal and ethics requirements for a safe and standardized exchange of biobanked samples collected within HBM4EU. In addition, thefollowing documents connected to this SOP are provided: Sample Data Transfer Template:This Excel sheet contains a template for sample data transfer that is required to be filled in when shipping samples Material and Associated Data Transfer Agreement:The HBM4EU MDTA is the basis for controlled sample exchange between the partners in HBM4EU. It is based on good scientific practice and takes into account relevant regulations of the General Data Protection Regulation (GDPR). Shipping Flowchart:This flowchart provides details on correct packaging, labelling and the shipment between EU countries. Pro-Forma Invoice:This document contains a pro-forma invoice to be filled out when shipping samples Sample Transfer Protocol: This document lays down the sample transfer protocol to be used when samples are being shipped within the HBM4EU programme including details on provider and receiver and respective checklists. The documents were also included in project deliverable D 7.2 and are available here as single files.

Published
2020
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29. Molecular fingerprinting of the fecal microbiota of children raised according to different lifestyles

Author

Dicksved, Johan, Floistrup, Helen, Bergstrom, Anna, Rosenquist, Magnus, Pershagen, Scheynius, Annika, Roos, Stefan, Alm, Johan S., Engstrand, Lars, Braun-Fahrlander, Charlotte, von Mutius, Erika, and Jansson, Janet K.

Subjects
Fingerprints -- Usage, Intestines -- Microbiology, Intestines -- Research, Biological sciences
Abstract

The terminal restriction fragment length polymorphism (T-RFLP) is used to investigate the relationship between the selected lifestyles factors and intestinal microbial community profiles in children raised according to different lifestyles. The results have shown that the different lifestyles might have an impact on the composition of the gut microbiota.

Published
2007

30. Applied relaxation: an experimental analogue study of therapist vs. computer administration

Author

Carlbring, Per, Bjornstjerna, Eva, Bergstrom, Anna F., Waara, Johan, and Andersson, Gerhard

Subjects
Computers, Psychology and mental health, Sociology and social work
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.chb.2004.03.032 Byline: Per Carlbring (a), Eva Bjornstjerna (a), Anna F. Bergstrom (a), Johan Waara (a), Gerhard Andersson (a)(b) Keywords: Applied relaxation; Computer administration; Internet; Psychophysiology Abstract: This experimental analog component study compared two ways of administrating relaxation, either via a computer or by a therapist. The second phase of applied relaxation was used, which is called 'release-only relaxation'. Sixty participants from a student population were randomized to one of three groups: computer-administered relaxation, therapist-administered relaxation, or a control group in which participants surfed on the Internet. Outcome was measures using psychophysiological responses and self-report. Objective psychophysiological data and results on the subjective visual analogue scale suggest that there was no difference between the two forms of administration. Both experimental groups became significantly more relaxed than the control group that surfed on the Internet. Practical applications and future directions are discussed. Author Affiliation: (a) Department of Psychology, Uppsala University, P.O. Box 1225, SE-751 42 Uppsala, Sweden (b) Department of Audiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden

Published
2007

31. The use of the PARIHS framework in implementation research and practice-a citation analysis of the literature

Author

Bergstrom, Anna, Ehrenberg, Anna, Eldh, Ann Catrine, Graham, Ian D., Gustafsson, Kazuko, Harvey, Gillian, Hunter, Sarah, Kitson, Alison, Rycroft-Malone, Jo, Wallin, Lars, Bergstrom, Anna, Ehrenberg, Anna, Eldh, Ann Catrine, Graham, Ian D., Gustafsson, Kazuko, Harvey, Gillian, Hunter, Sarah, Kitson, Alison, Rycroft-Malone, Jo, and Wallin, Lars

Abstract

Background The Promoting Action on Research Implementation in Health Services (PARIHS) framework was developed two decades ago and conceptualizes successful implementation (SI) as a function (f) of the evidence (E) nature and type, context (C) quality, and the facilitation (F), [SI = f (E,C,F)]. Despite a growing number of citations of theoretical frameworks including PARIHS, details of how theoretical frameworks are used remains largely unknown. This review aimed to enhance the understanding of the breadth and depth of the use of the PARIHS framework. Methods This citation analysis commenced from four core articles representing the key stages of the frameworks development. The citation search was performed in Web of Science and Scopus. After exclusion, we undertook an initial assessment aimed to identify articles using PARIHS and not only referencing any of the core articles. To assess this, all articles were read in full. Further data extraction included capturing information about where (country/countries and setting/s) PARIHS had been used, as well as categorizing how the framework was applied. Also, strengths and weaknesses, as well as efforts to validate the framework, were explored in detail. Results The citation search yielded 1613 articles. After applying exclusion criteria, 1475 articles were read in full, and the initial assessment yielded a total of 367 articles reported to have used the PARIHS framework. These articles were included for data extraction. The framework had been used in a variety of settings and in both high-, middle-, and low-income countries. With regard to types of use, 32% used PARIHS in planning and delivering an intervention, 50% in data analysis, 55% in the evaluation of study findings, and/or 37% in any other way. Further analysis showed that its actual application was frequently partial and generally not well elaborated. Conclusions In line with previous citation analysis of the use of theoretical frameworks in implementation scie, Funding Agencies|CIHR Foundation Grant (FDN)Canadian Institutes of Health Research (CIHR) [143237]; FORTE grant [COFAS-2, 2014-2733]; Uppsala University

Published
2020
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32. A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents

Author

Lemonnier, Nathanaël, Melen, Erik, Jiang, Yale, Joly, Stephane, Menard, Camille, Aguilar, Daniel, Acosta-Perez, Edna, Bergstrom, Anna, Boutaoui, Nadia, Bustamante, Mariona, Canino, Glorisa, Forno, Erick, Ramon Gonzalez, Juan, Garcia-Aymerich, Judith, Gruzieva, Olena, Guerra, Stefano, Heinrich, Joachim, Kull, Inger, Ibarluzea Maurolagoitia, Jesus, Santa-Marina Rodriguez, Loreto, Thiering, Elisabeth, Wickman, Magnus, Akdis, Cezmi, Akdis, Mübeccel, Chen, Wei, Keil, Thomas, Koppelman, Gerard H., Siroux, Valerie, Xu, Cheng-Jian, Hainaut, Pierre, Standl, Marie, Sunyer, Jordi, Celedon, Juan C., Maria Anto, Josep, Bousquet, Jean, Lemonnier, Nathanaël, Melen, Erik, Jiang, Yale, Joly, Stephane, Menard, Camille, Aguilar, Daniel, Acosta-Perez, Edna, Bergstrom, Anna, Boutaoui, Nadia, Bustamante, Mariona, Canino, Glorisa, Forno, Erick, Ramon Gonzalez, Juan, Garcia-Aymerich, Judith, Gruzieva, Olena, Guerra, Stefano, Heinrich, Joachim, Kull, Inger, Ibarluzea Maurolagoitia, Jesus, Santa-Marina Rodriguez, Loreto, Thiering, Elisabeth, Wickman, Magnus, Akdis, Cezmi, Akdis, Mübeccel, Chen, Wei, Keil, Thomas, Koppelman, Gerard H., Siroux, Valerie, Xu, Cheng-Jian, Hainaut, Pierre, Standl, Marie, Sunyer, Jordi, Celedon, Juan C., Maria Anto, Josep, and Bousquet, Jean

Abstract

Background: Allergic diseases often occur in combination (multimorbidity). Human blood transcriptome studies have not addressed multimorbidity. Large-scale gene expression data were combined to retrieve biomarkers and signaling pathways to disentangle allergic multimorbidity phenotypes. Methods: Integrated transcriptomic analysis was conducted in 1233 participants with a discovery phase using gene expression data (Human Transcriptome Array 2.0) from whole blood of 786 children from three European birth cohorts (MeDALL), and a replication phase using RNA Sequencing data from an independent cohort (EVA-PR, n = 447). Allergic diseases (asthma, atopic dermatitis, rhinitis) were considered as single disease or multimorbidity (at least two diseases), and compared with no disease. Results: Fifty genes were differentially expressed in allergic diseases. Thirty-two were not previously described in allergy. Eight genes were consistently overexpressed in all types of multimorbidity for asthma, dermatitis, and rhinitis (CLC, EMR4P, IL5RA, FRRS1, HRH4, SLC29A1, SIGLEC8, IL1RL1). All genes were replicated the in EVA-PR cohort. RT-qPCR validated the overexpression of selected genes. In MeDALL, 27 genes were differentially expressed in rhinitis alone, but none was significant for asthma or dermatitis alone. The multimorbidity signature was enriched in eosinophil-associated immune response and signal transduction. Protein-protein interaction network analysis identified IL5/JAK/STAT and IL33/ST2/IRAK/TRAF as key signaling pathways in multimorbid diseases. Synergistic effect of multimorbidity on gene expression levels was found. Conclusion: A signature of eight genes identifies multimorbidity for asthma, rhinitis, and dermatitis. Our results have clinical and mechanistic implications, and suggest that multimorbidity should be considered differently than allergic diseases occurring alone.

Published
2020
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33. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Author

Merid, Simon Kebede, Novoloaca, Alexei, Sharp, Gemma C., Kupers, Leanne K., Kho, Alvin T., Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne O., Kazmi, Nabila, Salas, Lucas A., Rezwan, Faisal I., Zhang, Hongmei, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl L., Melton, Phillip E., Lawlor, Debbie A., Pershagen, Goran, Breton, Carrie V., Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim S., Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen Aagaard, Bustamante, Mariona, Ewart, Susan L., Karmaus, Wilfried, Zhao, Shanshan, Page, Christian M., Herceg, Zdenko, Jarvelin, Marjo-Riitta, Lahti, Jari, Baccarelli, Andrea A., Anderson, Denise, Kachroo, Priyadarshini, Relton, Caroline L., Bergstrom, Anna, Eskenazi, Brenda, Soomro, Munawar Hussain, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent W., Sørensen, Thorkild I. A., Vrijheid, Martine, Arshad, S. Hasan, Holloway, John W., Haberg, Siri E., Magnus, Per, Dwyer, Terence, Binder, Elisabeth B., DeMeo, Dawn L., Vonk, Judith M., Newnham, John, Tantisira, Kelan G., Kull, Inger, Wiemels, Joseph L., Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica C., Raikkonen, Katri, Oken, Emily, Huang, Rae-Chi, Weiss, Scott T., Anto, Josep Maria, Bousquet, Jean, Kumar, Ashish, Soderhall, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah E., Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Hivert, Marie-France, Felix, Janine F., Koppelman, Gerard H., London, Stephanie J., Melen, Erik, Merid, Simon Kebede, Novoloaca, Alexei, Sharp, Gemma C., Kupers, Leanne K., Kho, Alvin T., Roy, Ritu, Gao, Lu, Annesi-Maesano, Isabella, Jain, Pooja, Plusquin, Michelle, Kogevinas, Manolis, Allard, Catherine, Vehmeijer, Florianne O., Kazmi, Nabila, Salas, Lucas A., Rezwan, Faisal I., Zhang, Hongmei, Sebert, Sylvain, Czamara, Darina, Rifas-Shiman, Sheryl L., Melton, Phillip E., Lawlor, Debbie A., Pershagen, Goran, Breton, Carrie V., Huen, Karen, Baiz, Nour, Gagliardi, Luigi, Nawrot, Tim S., Corpeleijn, Eva, Perron, Patrice, Duijts, Liesbeth, Nohr, Ellen Aagaard, Bustamante, Mariona, Ewart, Susan L., Karmaus, Wilfried, Zhao, Shanshan, Page, Christian M., Herceg, Zdenko, Jarvelin, Marjo-Riitta, Lahti, Jari, Baccarelli, Andrea A., Anderson, Denise, Kachroo, Priyadarshini, Relton, Caroline L., Bergstrom, Anna, Eskenazi, Brenda, Soomro, Munawar Hussain, Vineis, Paolo, Snieder, Harold, Bouchard, Luigi, Jaddoe, Vincent W., Sørensen, Thorkild I. A., Vrijheid, Martine, Arshad, S. Hasan, Holloway, John W., Haberg, Siri E., Magnus, Per, Dwyer, Terence, Binder, Elisabeth B., DeMeo, Dawn L., Vonk, Judith M., Newnham, John, Tantisira, Kelan G., Kull, Inger, Wiemels, Joseph L., Heude, Barbara, Sunyer, Jordi, Nystad, Wenche, Munthe-Kaas, Monica C., Raikkonen, Katri, Oken, Emily, Huang, Rae-Chi, Weiss, Scott T., Anto, Josep Maria, Bousquet, Jean, Kumar, Ashish, Soderhall, Cilla, Almqvist, Catarina, Cardenas, Andres, Gruzieva, Olena, Xu, Cheng-Jian, Reese, Sarah E., Kere, Juha, Brodin, Petter, Solomon, Olivia, Wielscher, Matthias, Holland, Nina, Ghantous, Akram, Hivert, Marie-France, Felix, Janine F., Koppelman, Gerard H., London, Stephanie J., and Melen, Erik

Published
2020

38. Towards Harmonized Biobanking for Biomonitoring: A Comparison of Human Biomonitoring-Related and Clinical Biorepositories

Author

Lermen, Dominik, primary, Gwinner, Frederik, additional, Bartel-Steinbach, Martina, additional, Mueller, Sabine C., additional, Habermann, Jens K., additional, Balwir, Matharoo-Ball, additional, Smits, Elke, additional, Virgolino, Ana, additional, Fiddicke, Ulrike, additional, Berglund, Marika, additional, Åkesson, Agneta, additional, Bergstrom, Anna, additional, Leander, Karin, additional, Horvat, Milena, additional, Snoj Tratnik, Janja, additional, Posada de la Paz, Manuel, additional, Castaño Calvo, Argelia, additional, Esteban López, Marta, additional, von Briesen, Hagen, additional, Zimmermann, Heiko, additional, and Kolossa-Gehring, Marike, additional

Published
2020
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42. Use of multivitamin supplements in relation to allergic disease in 8-y-old children

Author

Marmsjo, Kristin, Rosenlund, Helen, Kull, Inger, Hakansson, Niclas, Wickman, Magnus, Pershagen, Goran, and Bergstrom, Anna

Subjects
Allergic reaction -- Research, Allergic reaction -- Risk factors, Allergic reaction -- Prevention, Allergy -- Research, Allergy -- Risk factors, Allergy -- Prevention, Multivitamins -- Health aspects, Children -- Health aspects, Food/cooking/nutrition, Health
Abstract

Background: Multivitamins are frequently consumed by children, but it is unclear whether this affects the risk of allergic disease. Objective: We sought to study the association between multivitamin supplementation and allergic disease in 8-y-old children. Design: Data were obtained from a Swedish birth cohort study. Information on lifestyle factors, including use of vitamin supplements, environmental exposures, and symptoms and diagnoses of allergic diseases, was obtained by parental questionnaires. In addition, allergen-specific IgE concentrations of food and airborne allergens were measured in blood samples collected at age 8 y. A total of 2423 children were included in the study. The association between use of vitamin supplements and the selected health outcomes was analyzed with logistic regression. Results: Overall, no strong and consistent associations were observed between current multivitamin use and asthma, allergic rhinitis, eczema, or atopic sensitization at age 8 y. However, children who reported that they started taking multivitamins before or at age 4 y had a decreased risk of sensitization to food allergens (odds ratio: 0.61; 95% CI: 0.39, 0.97) and tendencies toward inverse associations with allergic rhinitis. In contrast, there was no consistent association among children who started to use multivitamins at or after age 5 y. Conclusion: Our results show no association between current use of multivitamins and risk of allergic disease but suggest that supplementation with multivitamins during the first years of life may reduce the risk of allergic disease at school age. Am J Clin Nutr 2009;90:1693-8. DOI: 10.3945/ajcn.2009.27963

Published
2009

43. Occupational exposure to endocrine-disrupting chemicals and birth weight and length of gestation: a European meta-analysis

Author

Birks, Laura, Casas, Maribel, Garcia, Ana M., Alexander, Jan, Barros, Henrique, Bergstrom, Anna, Bonde, Jens Peter, Burdorf, Alex, Costet, Nathalie, Danileviciute, Asta, Eggesbo, Merete, Fernandez, Mariana F., Gonzalez-Galarzo, M. Carmen, Grazuleviciene, Regina, Hanke, Wojciech, Jaddoe, Vincent, Kogevinas, Manolis, Kull, Inger, Lertxundi, Aitana, Melaki, Vasiliki, Andersen, Anne-Marie Nybo, Olea, Nicolas, Polanska, Kinga, Rusconi, Franca, Santa-Marina, Loreto, Santos, Ana Cristina, Vrijkotte, Tanja, Zugna, Daniela, Nieuwenhuijsen, Mark, Cordier, Sylvaine, and Vrijheid, Martine

Subjects
Endocrine disruptors -- Research, Meta-analysis, Birth weight -- Health aspects -- Research, Occupational exposure -- Research, Pregnancy -- Health aspects, Environmental issues, Health
Abstract

BACKGROUND: Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth. OBJECTIVES: We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery. METHODS: Using individual participant data from 133,957 mother-child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates. RESULTS: Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation. CONCLUSION: Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW. http://dx.doi.org/10.1289/EHP208, Introduction Background Potential endocrine-disrupting chemicals (EDCs) have been described as human-made substances that alter hormone regulation in humans or wildlife (WHO/UNEP 2012). The endocrine system regulates many essential body functions [...]

Published
2016
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45. A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention

Author

Jung, Christian, Wernly, Bernhard, Muessig, Johanna M., Kelm, Malte, Boumendil, Ariane, Morandi, Alessandro, Andersen, Finn H., Artigas, Antonio, Bertolini, Guido, Cecconi, Maurizio, Christensen, Steffen, Faraldi, Loredana, Fjolner, Jesper, Lichtenauer, Michael, Bruno, Raphael Romano, Marsh, Brian, Moreno, Rui, Oeyen, Sandra, Ohman, Christina Agvald, Pinto, Bernadro Bollen, Soliman, Ivo W., Szczeklik, Wojciech, Valentin, Andreas, Watson, Ximena, Zafeiridis, Tilemachos, De Lange, Dylan W., Guidet, Bertrand, Flaatten, Hans, Schmutz, Rene, Wimmer, Franz, Eller, Philipp, Joannidis, Michael, De Buysscher, Pieter, De Neve, Nikolaas, Swinnen, Walter, Abraham, Paul, Hergafi, Leila, Schefold, Joerg C., Biskup, Ewelina, Piza, Petr, Taliadoros, Ioannis, Dey, Nilanjan, Solling, Christoffer, Rasmussen, Bodil Steen, Forceville, Xavier, Besch, Guillaume, Mentec, Herve, Michel, Philippe, Mateu, Philippe, Vettoretti, Lucie, Bourenne, Jeremy, Marin, Nathalie, Guillot, Max, Aissaoui, Naida, Goulenok, Cyril, Thieulot-Rolin, Nathalie, Messika, Jonathan, Lamhaut, Lionel, Charron, Cyril, Lauten, Alexander, Sacher, Anna Lena, Brenner, Thorsten, Franz, Marcus, Bloos, Frank, Ebelt, Henning, Schaller, Stefan J., Fuest, Kristina, Rabe, Christian, Dieck, Thorben, Steiner, Stephan, Graf, Tobias, Nia, Amir M., Janosi, Rolf Alexander, Meybohm, Patrick, Simon, Philipp, Utzolino, Stefan, Rahmel, Tim, Barth, Eberhard, Schuster, Michael, Aidoni, Zoi, Aloizos, Stavros, Tasioudis, Polychronis, Lampiri, Kleri, Zisopoulou, Vasiliki, Ravani, Ifigenia, Pagaki, Eumorfia, Antoniou, Angela, Katsoulas, Theodoros A., Kounougeri, Aikaterini, Marinakis, George, Tsimpoukas, Fotios, Spyropoulou, Anastasia, Zygoulis, Paris, Kyparissi, Aikaterini, Gupta, Manish, Gurjar, Mohan, Maji, Ismail M., Hayes, Ivan, Kelly, Yvelynne, Westbrook, Andrew, Fitzpatrick, Gerry, Maheshwari, Darshana, Motherway, Catherine, Negri, Giovanni, Spadaro, Savino, Nattino, Giuseppe, Pedeferri, Matteo, Boscolo, Annalisa, Rossi, Simona, Calicchio, Giuseppe, Cubattoli, Lucia, Di Lascio, Gabriella, Barbagallo, Maria, Berruto, Francesco, Codazzi, Daniela, Bottazzi, Andrea, Fumagalli, Paolo, Negro, Giancarlo, Lupi, Giuseppe, Savelli, Flavia, Vulcano, Giuseppe A., Fumagalli, Roberto, Marudi, Andrea, Lefons, Ugo, Lembo, Rita, Babini, Maria, Paggioro, Alessandra, Parrini, Vieri, Zaccaria, Maria, Clementi, Stefano, Gigliuto, Carmelo, Facondini, Francesca, Pastorini, Simonetta, Munaron, Susanna, Calamai, Italo, Bocchi, Anna, Adorni, Adele, Bocci, Maria Grazia, Cortegiani, Andrea, Casalicchio, Tiziana, Mellea, Serena, Graziani, Elia, Barattini, Massimo, Brizio, Elisabetta, Rossi, Maurizio, Hahn, Michael, Kemmerer, Nicolai, Strietzel, Hans Frank, Dybwik, Knut, Legernaes, Terje, Klepstad, Pal, Olaussen, Even Braut, Olsen, Knut Inge, Brresen, Ole Marius, Bjorsvik, Geir, Maini, Sameer, Fehrle, Lutz, Czuczwar, Miroslaw, Krawczyk, Pawel, Zietkiewicz, Miroslaw, Nowak, Lukasz R., Kotfis, Katarzyna, Cwyl, Katarzyna, Gajdosz, Ryszard, Biernawska, Jowita, Bohatyrewicz, Romuald, Gawda, Ryszard, Grudzien, Pawel, Nasilowski, Pawel, Popek, Natalia, Cyrankiewicz, Waldemar, Wawrzyniak, Katarzyna, Wnuk, Marek, Maciejewski, Dariusz, Studzinska, Dorota, Zukowski, Maciej, Bernas, Szymon, Piechota, Mariusz, Nowak, Ilona, Fronczek, Jakub, Serwa, Marta, Machala, Waldemar, Stefaniak, Jan, Wujtewicz, Maria, Maciejewski, Pawel, Szymkowiak, Malgorzata, Adamik, Barbara, Catorze, Nuno, Branco, Miguel Castelo, Barros, Ines, Barros, Nelson, Krystopchuk, Andriy, Honrado, Teresa, Sousa, Cristina, Munoz, Francisco, Rebelo, Marta, Gomes, Rui, Nunes, Jorge, Dias, Celeste, Fernandes, Ana Margarida, Petrisor, Cristina, Constantin, Bodolea, Belskiy, Vladislav, Boskholov, Boris, Rodriguez, Enver, Rebollo, Sergio, Aguilar, Gerardo, Masdeu, Gaspar, Irazabal Jaimes, Marian, Prado Mira, Angela, Bodi, Maria A., Barea Mendoza, Jesus A., Lopez-Cuenca, Sonia, Homez Guzman, Marcela, Rico-Feijoo, Jesus, Ibarz, Mercedes, Trenado Alvarez, Josep, Kawati, Rafael, Sivik, Joakim, Nauska, Jessica, Smole, Daniel, Parenmark, Fredric, Lyren, Johanna, Rockstroh, Katalin, Ryden, Sara, Spangfors, Martin, Strinnholm, Morten, Walther, Sten, De Geer, Lina, Nordlund, Peter, Palsson, Staffan, Zetterquist, Harald, Nilsson, Annika, Thiringer, Karin, Jungner, Marten, Bark, Bjorn, Nordling, Berit, Skold, Hans, Brorsson, Camilla, Persson, Stefan, Bergstrom, Anna, Berkius, Johan, Holmstrom, Johanna, van Dijk, I, van Lelyveld-Haas, L. E. M., Ramnarain, D., Jansen, Tim, Nooteboom, Fleur, van der Voort, Peter H. J., de Lange, Dylan, Dieperink, Willem, de Waard, Monique C., de Smet, Annemarie G. E., Bormans, Laura, Dormans, Tom, Dempsey, Ged, Mathew, Shiju J., Raj, Ashok S., Grecu, Irina, Cupitt, Jason, Lawton, Tom, Clark, Richard, Popescu, Monica, Spittle, Nick, Faulkner, Maria, Cowton, Amanda, Elloway, Esme, Williams, Patricia, Reay, Michael, Chukkambotla, Srikanth, Kumar, Ravi, Al-Subaie, Nawaf, Kent, Linda, Tamm, Tiina, Kajtor, Istvan, Burns, Karen, Pugh, Richard, Ostermann, Marlies, Kam, Elisa, Bowyer, Helen, Smith, Neil, Templeton, Maie, Henning, Jeremy, Goffin, Kelly, Kapoor, Ritoo, Laha, Shondipon, Chilton, Phil, Khaliq, Waqas, Crayford, Alison, Coetzee, Samantha, Tait, Moira, Stoker, Wendy, Gimenez, Marc, Pope, Alan, Camsooksai, Julie, Pogson, David, Quigley, Kate, Ritzema, Jenny, Hormis, Anil, Boulanger, Carole, Balasubramaniam, M., Vamplew, Luke, Burt, Karen, Martin, Daniel, Craig, Jayne, Prowle, John, Doyle, Nanci, Shelton, Jonathon, Scott, Carmen, Donnison, Phil, Shelton, Sarah, Frey, Christian, Ryan, Christine, Spray, Dominic, Barnes, Veronica, Barnes, Kerry, Ridgway, Stephanie, Saha, Rajnish, Clark, Thomas, Wood, James, Bolger, Clare, Bassford, Christopher, Lewandowski, John, Zhao, Xiaobei, Humphreys, Sally, Dowling, Susan, Richardson, Neil, Burtenshaw, Andrew, Stevenson, Carl, Wilcock, Danielle, Nalapko, Yuiry, Jung, Christian, Wernly, Bernhard, Muessig, Johanna M., Kelm, Malte, Boumendil, Ariane, Morandi, Alessandro, Andersen, Finn H., Artigas, Antonio, Bertolini, Guido, Cecconi, Maurizio, Christensen, Steffen, Faraldi, Loredana, Fjolner, Jesper, Lichtenauer, Michael, Bruno, Raphael Romano, Marsh, Brian, Moreno, Rui, Oeyen, Sandra, Ohman, Christina Agvald, Pinto, Bernadro Bollen, Soliman, Ivo W., Szczeklik, Wojciech, Valentin, Andreas, Watson, Ximena, Zafeiridis, Tilemachos, De Lange, Dylan W., Guidet, Bertrand, Flaatten, Hans, Schmutz, Rene, Wimmer, Franz, Eller, Philipp, Joannidis, Michael, De Buysscher, Pieter, De Neve, Nikolaas, Swinnen, Walter, Abraham, Paul, Hergafi, Leila, Schefold, Joerg C., Biskup, Ewelina, Piza, Petr, Taliadoros, Ioannis, Dey, Nilanjan, Solling, Christoffer, Rasmussen, Bodil Steen, Forceville, Xavier, Besch, Guillaume, Mentec, Herve, Michel, Philippe, Mateu, Philippe, Vettoretti, Lucie, Bourenne, Jeremy, Marin, Nathalie, Guillot, Max, Aissaoui, Naida, Goulenok, Cyril, Thieulot-Rolin, Nathalie, Messika, Jonathan, Lamhaut, Lionel, Charron, Cyril, Lauten, Alexander, Sacher, Anna Lena, Brenner, Thorsten, Franz, Marcus, Bloos, Frank, Ebelt, Henning, Schaller, Stefan J., Fuest, Kristina, Rabe, Christian, Dieck, Thorben, Steiner, Stephan, Graf, Tobias, Nia, Amir M., Janosi, Rolf Alexander, Meybohm, Patrick, Simon, Philipp, Utzolino, Stefan, Rahmel, Tim, Barth, Eberhard, Schuster, Michael, Aidoni, Zoi, Aloizos, Stavros, Tasioudis, Polychronis, Lampiri, Kleri, Zisopoulou, Vasiliki, Ravani, Ifigenia, Pagaki, Eumorfia, Antoniou, Angela, Katsoulas, Theodoros A., Kounougeri, Aikaterini, Marinakis, George, Tsimpoukas, Fotios, Spyropoulou, Anastasia, Zygoulis, Paris, Kyparissi, Aikaterini, Gupta, Manish, Gurjar, Mohan, Maji, Ismail M., Hayes, Ivan, Kelly, Yvelynne, Westbrook, Andrew, Fitzpatrick, Gerry, Maheshwari, Darshana, Motherway, Catherine, Negri, Giovanni, Spadaro, Savino, Nattino, Giuseppe, Pedeferri, Matteo, Boscolo, Annalisa, Rossi, Simona, Calicchio, Giuseppe, Cubattoli, Lucia, Di Lascio, Gabriella, Barbagallo, Maria, Berruto, Francesco, Codazzi, Daniela, Bottazzi, Andrea, Fumagalli, Paolo, Negro, Giancarlo, Lupi, Giuseppe, Savelli, Flavia, Vulcano, Giuseppe A., Fumagalli, Roberto, Marudi, Andrea, Lefons, Ugo, Lembo, Rita, Babini, Maria, Paggioro, Alessandra, Parrini, Vieri, Zaccaria, Maria, Clementi, Stefano, Gigliuto, Carmelo, Facondini, Francesca, Pastorini, Simonetta, Munaron, Susanna, Calamai, Italo, Bocchi, Anna, Adorni, Adele, Bocci, Maria Grazia, Cortegiani, Andrea, Casalicchio, Tiziana, Mellea, Serena, Graziani, Elia, Barattini, Massimo, Brizio, Elisabetta, Rossi, Maurizio, Hahn, Michael, Kemmerer, Nicolai, Strietzel, Hans Frank, Dybwik, Knut, Legernaes, Terje, Klepstad, Pal, Olaussen, Even Braut, Olsen, Knut Inge, Brresen, Ole Marius, Bjorsvik, Geir, Maini, Sameer, Fehrle, Lutz, Czuczwar, Miroslaw, Krawczyk, Pawel, Zietkiewicz, Miroslaw, Nowak, Lukasz R., Kotfis, Katarzyna, Cwyl, Katarzyna, Gajdosz, Ryszard, Biernawska, Jowita, Bohatyrewicz, Romuald, Gawda, Ryszard, Grudzien, Pawel, Nasilowski, Pawel, Popek, Natalia, Cyrankiewicz, Waldemar, Wawrzyniak, Katarzyna, Wnuk, Marek, Maciejewski, Dariusz, Studzinska, Dorota, Zukowski, Maciej, Bernas, Szymon, Piechota, Mariusz, Nowak, Ilona, Fronczek, Jakub, Serwa, Marta, Machala, Waldemar, Stefaniak, Jan, Wujtewicz, Maria, Maciejewski, Pawel, Szymkowiak, Malgorzata, Adamik, Barbara, Catorze, Nuno, Branco, Miguel Castelo, Barros, Ines, Barros, Nelson, Krystopchuk, Andriy, Honrado, Teresa, Sousa, Cristina, Munoz, Francisco, Rebelo, Marta, Gomes, Rui, Nunes, Jorge, Dias, Celeste, Fernandes, Ana Margarida, Petrisor, Cristina, Constantin, Bodolea, Belskiy, Vladislav, Boskholov, Boris, Rodriguez, Enver, Rebollo, Sergio, Aguilar, Gerardo, Masdeu, Gaspar, Irazabal Jaimes, Marian, Prado Mira, Angela, Bodi, Maria A., Barea Mendoza, Jesus A., Lopez-Cuenca, Sonia, Homez Guzman, Marcela, Rico-Feijoo, Jesus, Ibarz, Mercedes, Trenado Alvarez, Josep, Kawati, Rafael, Sivik, Joakim, Nauska, Jessica, Smole, Daniel, Parenmark, Fredric, Lyren, Johanna, Rockstroh, Katalin, Ryden, Sara, Spangfors, Martin, Strinnholm, Morten, Walther, Sten, De Geer, Lina, Nordlund, Peter, Palsson, Staffan, Zetterquist, Harald, Nilsson, Annika, Thiringer, Karin, Jungner, Marten, Bark, Bjorn, Nordling, Berit, Skold, Hans, Brorsson, Camilla, Persson, Stefan, Bergstrom, Anna, Berkius, Johan, Holmstrom, Johanna, van Dijk, I, van Lelyveld-Haas, L. E. M., Ramnarain, D., Jansen, Tim, Nooteboom, Fleur, van der Voort, Peter H. J., de Lange, Dylan, Dieperink, Willem, de Waard, Monique C., de Smet, Annemarie G. E., Bormans, Laura, Dormans, Tom, Dempsey, Ged, Mathew, Shiju J., Raj, Ashok S., Grecu, Irina, Cupitt, Jason, Lawton, Tom, Clark, Richard, Popescu, Monica, Spittle, Nick, Faulkner, Maria, Cowton, Amanda, Elloway, Esme, Williams, Patricia, Reay, Michael, Chukkambotla, Srikanth, Kumar, Ravi, Al-Subaie, Nawaf, Kent, Linda, Tamm, Tiina, Kajtor, Istvan, Burns, Karen, Pugh, Richard, Ostermann, Marlies, Kam, Elisa, Bowyer, Helen, Smith, Neil, Templeton, Maie, Henning, Jeremy, Goffin, Kelly, Kapoor, Ritoo, Laha, Shondipon, Chilton, Phil, Khaliq, Waqas, Crayford, Alison, Coetzee, Samantha, Tait, Moira, Stoker, Wendy, Gimenez, Marc, Pope, Alan, Camsooksai, Julie, Pogson, David, Quigley, Kate, Ritzema, Jenny, Hormis, Anil, Boulanger, Carole, Balasubramaniam, M., Vamplew, Luke, Burt, Karen, Martin, Daniel, Craig, Jayne, Prowle, John, Doyle, Nanci, Shelton, Jonathon, Scott, Carmen, Donnison, Phil, Shelton, Sarah, Frey, Christian, Ryan, Christine, Spray, Dominic, Barnes, Veronica, Barnes, Kerry, Ridgway, Stephanie, Saha, Rajnish, Clark, Thomas, Wood, James, Bolger, Clare, Bassford, Christopher, Lewandowski, John, Zhao, Xiaobei, Humphreys, Sally, Dowling, Susan, Richardson, Neil, Burtenshaw, Andrew, Stevenson, Carl, Wilcock, Danielle, and Nalapko, Yuiry

Abstract

Background: We aimed to evaluate differences in outcome between patients admitted to intensive care unit (ICU) after elective versus acute surgery in a multinational cohort of very old patients (80 years; VIP). Predictors of mortality, with special emphasis on frailty, were assessed. Methods: In total, 5063 VIPs were induded in this analysis, 922 were admitted after elective surgery or intervention, 4141 acutely, with 402 after acute surgery. Differences were calculated using Mann-Whitney-U test and Wilcoxon test. Univariate and multivariable logistic regression were used to assess associations with mortality. Results: Compared patients admitted after acute surgery, patients admitted after elective surgery suffered less often from frailty as defined as CFS (28% vs 46%; p < 0.001), evidenced lower SOFA scores (4 +/- 5 vs 7 +/- 7; p < 0.001). Presence of frailty (CFS >4) was associated with significantly increased mortality both in elective surgery patients (7% vs 12%; p = 0.01), in acute surgery (7% vs 12%; p = 0.02). Conclusions: VIPs admitted to ICU after elective surgery evidenced favorable outcome over patients after acute surgery even after correction for relevant confounders. Frailty might be used to guide clinicians in risk stratification in both patients admitted after elective and acute surgery.

Published
2019
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46. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood:An individual participant data meta-analysis

Author

Voerman, Ellis, Santos, Susana, Golab, Bernadeta Patro, Amiano, Pilar, Ballester, Ferran, Barros, Henrique, Bergstrom, Anna, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cecile, Chrousos, George P., Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Eggesbo, Merete, Ekstrom, Sandra, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Georgiu, Vagelis, Godfrey, Keith M., Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Iszatt, Nina, Karvonen, Anne M., Kenny, Louise C., Koletzko, Berthold, Kupers, Leanne K., Lagstrom, Hanna, Lehmann, Irina, Magnus, Per, Majewska, Renata, Makela, Johanna, Manios, Yannis, McAuliffe, Fionnuala M., McDonald, Sheila W., Mehegan, John, Mommers, Monique, Morgen, Camilla S., Mori, Trevor A., Moschonis, George, Murray, Deirdre, Chaoimh, Carol Ni, Nohr, Ellen A., Andersen, Anne-Marie Nybo, Oken, Emily, Oostvogels, Adriette J. J. M., Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L., Ronfani, Luca, Santos, Ana C., Standl, Marie, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Maties, Tough, Suzanne C., Trnovec, Tomas, Turner, Steve, Van Rossem, Lenie, Von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja G. M., West, Jane, Wijga, Alet, Wright, John, Zvinchuk, Oleksandr, Sørensen, Thorkild I. A., Lawlor, Debbie A., Gaillard, Romy, Jaddoe, Vincent W. V., Voerman, Ellis, Santos, Susana, Golab, Bernadeta Patro, Amiano, Pilar, Ballester, Ferran, Barros, Henrique, Bergstrom, Anna, Charles, Marie-Aline, Chatzi, Leda, Chevrier, Cecile, Chrousos, George P., Corpeleijn, Eva, Costet, Nathalie, Crozier, Sarah, Devereux, Graham, Eggesbo, Merete, Ekstrom, Sandra, Fantini, Maria Pia, Farchi, Sara, Forastiere, Francesco, Georgiu, Vagelis, Godfrey, Keith M., Gori, Davide, Grote, Veit, Hanke, Wojciech, Hertz-Picciotto, Irva, Heude, Barbara, Hryhorczuk, Daniel, Huang, Rae-Chi, Inskip, Hazel, Iszatt, Nina, Karvonen, Anne M., Kenny, Louise C., Koletzko, Berthold, Kupers, Leanne K., Lagstrom, Hanna, Lehmann, Irina, Magnus, Per, Majewska, Renata, Makela, Johanna, Manios, Yannis, McAuliffe, Fionnuala M., McDonald, Sheila W., Mehegan, John, Mommers, Monique, Morgen, Camilla S., Mori, Trevor A., Moschonis, George, Murray, Deirdre, Chaoimh, Carol Ni, Nohr, Ellen A., Andersen, Anne-Marie Nybo, Oken, Emily, Oostvogels, Adriette J. J. M., Pac, Agnieszka, Papadopoulou, Eleni, Pekkanen, Juha, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Rifas-Shiman, Sheryl L., Ronfani, Luca, Santos, Ana C., Standl, Marie, Stoltenberg, Camilla, Thiering, Elisabeth, Thijs, Carel, Torrent, Maties, Tough, Suzanne C., Trnovec, Tomas, Turner, Steve, Van Rossem, Lenie, Von Berg, Andrea, Vrijheid, Martine, Vrijkotte, Tanja G. M., West, Jane, Wijga, Alet, Wright, John, Zvinchuk, Oleksandr, Sørensen, Thorkild I. A., Lawlor, Debbie A., Gaillard, Romy, and Jaddoe, Vincent W. V.

Published
2019

47. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Author

Kupers, Leanne K., Monnereau, Claire, Sharp, Gemma C., Yousefi, Paul, Salas, Lucas A., Ghantous, Akram, Page, Christian M., Reese, Sarah E., Wilcox, Allen J., Czamara, Darina, Starling, Anne P., Novoloaca, Alexei, Lent, Samantha, Roy, Ritu, Hoyo, Cathrine, Breton, Carrie, V, Allard, Catherine, Just, Allan C., Bakulski, Kelly M., Holloway, John W., Everson, Todd M., Xu, Cheng-Jian, Huang, Rae-Chi, van der Plaat, Diana A., Wielscher, Matthias, Merid, Simon Kebede, Ullemar, Vilhelmina, Rezwan, Faisal, I, Lahti, Jari, van Dongen, Jenny, Langie, Sabine A. S., Richardson, Tom G., Magnus, Maria C., Nohr, Ellen A., Xu, Zongli, Duijts, Liesbeth, Zhao, Shanshan, Zhang, Weiming, Plusquin, Michelle, DeMeo, Dawn L., Solomon, Olivia, Heimovaara, Joosje H., Jima, Dereje D., Gao, Lu, Bustamante, Mariona, Perron, Patrice, Wright, Robert O., Hertz-Picciotto, Irva, Zhang, Hongmei, Karagas, Margaret R., Gehring, Ulrike, Marsit, Carmen J., Beilin, Lawrence J., Vonk, Judith M., Jarvelin, Marjo-Riitta, Bergstrom, Anna, Ortqvist, Anne K., Ewart, Susan, Villa, Pia M., Moore, Sophie E., Willemsen, Gonneke, Standaert, Arnout R. L., Haberg, Siri E., Sørensen, Thorkild I. A., Taylor, Jack A., Raikkonen, Katri, Yang, Ivana, V, Kechris, Katerina, Nawrot, Tim S., Silver, Matt J., Gong, Yun Yun, Richiardi, Lorenzo, Kogevinas, Manolis, Litonjua, Augusto A., Eskenazi, Brenda, Huen, Karen, Mbarek, Hamdi, Maguire, Rachel L., Dwyer, Terence, Vrijheid, Martine, Bouchard, Luigi, Baccarelli, Andrea A., Croen, Lisa A., Karmaus, Wilfried, Anderson, Denise, de Vries, Maaike, Sebert, Sylvain, Kere, Juha, Karlsson, Robert, Arshad, Syed Hasan, Hamalainen, Esa, Routledge, Michael N., Boomsma, Dorret, I, Feinberg, Andrew P., Newschaffer, Craig J., Govarts, Eva, Moisse, Matthieu, Fallin, M. Daniele, Melen, Erik, Prentice, Andrew M., Kajantie, Eero, Almqvist, Catarina, Oken, Emily, Dabelea, Dana, Boezen, H. Marike, Melton, Phillip E., Wright, Rosalind J., Koppelman, Gerard H., Trevisi, Letizia, Hivert, Marie-France, Sunyer, Jordi, Munthe-Kaas, Monica C., Murphy, Susan K., Corpeleijn, Eva, Wiemels, Joseph, Holland, Nina, Herceg, Zdenko, Binder, Elisabeth B., Smith, George Davey, Jaddoe, Vincent W. V., Lie, Rolv T., Nystad, Wenche, London, Stephanie J., Lawlor, Debbie A., Relton, Caroline L., Snieder, Harold, Felix, Janine F., Kupers, Leanne K., Monnereau, Claire, Sharp, Gemma C., Yousefi, Paul, Salas, Lucas A., Ghantous, Akram, Page, Christian M., Reese, Sarah E., Wilcox, Allen J., Czamara, Darina, Starling, Anne P., Novoloaca, Alexei, Lent, Samantha, Roy, Ritu, Hoyo, Cathrine, Breton, Carrie, V, Allard, Catherine, Just, Allan C., Bakulski, Kelly M., Holloway, John W., Everson, Todd M., Xu, Cheng-Jian, Huang, Rae-Chi, van der Plaat, Diana A., Wielscher, Matthias, Merid, Simon Kebede, Ullemar, Vilhelmina, Rezwan, Faisal, I, Lahti, Jari, van Dongen, Jenny, Langie, Sabine A. S., Richardson, Tom G., Magnus, Maria C., Nohr, Ellen A., Xu, Zongli, Duijts, Liesbeth, Zhao, Shanshan, Zhang, Weiming, Plusquin, Michelle, DeMeo, Dawn L., Solomon, Olivia, Heimovaara, Joosje H., Jima, Dereje D., Gao, Lu, Bustamante, Mariona, Perron, Patrice, Wright, Robert O., Hertz-Picciotto, Irva, Zhang, Hongmei, Karagas, Margaret R., Gehring, Ulrike, Marsit, Carmen J., Beilin, Lawrence J., Vonk, Judith M., Jarvelin, Marjo-Riitta, Bergstrom, Anna, Ortqvist, Anne K., Ewart, Susan, Villa, Pia M., Moore, Sophie E., Willemsen, Gonneke, Standaert, Arnout R. L., Haberg, Siri E., Sørensen, Thorkild I. A., Taylor, Jack A., Raikkonen, Katri, Yang, Ivana, V, Kechris, Katerina, Nawrot, Tim S., Silver, Matt J., Gong, Yun Yun, Richiardi, Lorenzo, Kogevinas, Manolis, Litonjua, Augusto A., Eskenazi, Brenda, Huen, Karen, Mbarek, Hamdi, Maguire, Rachel L., Dwyer, Terence, Vrijheid, Martine, Bouchard, Luigi, Baccarelli, Andrea A., Croen, Lisa A., Karmaus, Wilfried, Anderson, Denise, de Vries, Maaike, Sebert, Sylvain, Kere, Juha, Karlsson, Robert, Arshad, Syed Hasan, Hamalainen, Esa, Routledge, Michael N., Boomsma, Dorret, I, Feinberg, Andrew P., Newschaffer, Craig J., Govarts, Eva, Moisse, Matthieu, Fallin, M. Daniele, Melen, Erik, Prentice, Andrew M., Kajantie, Eero, Almqvist, Catarina, Oken, Emily, Dabelea, Dana, Boezen, H. Marike, Melton, Phillip E., Wright, Rosalind J., Koppelman, Gerard H., Trevisi, Letizia, Hivert, Marie-France, Sunyer, Jordi, Munthe-Kaas, Monica C., Murphy, Susan K., Corpeleijn, Eva, Wiemels, Joseph, Holland, Nina, Herceg, Zdenko, Binder, Elisabeth B., Smith, George Davey, Jaddoe, Vincent W. V., Lie, Rolv T., Nystad, Wenche, London, Stephanie J., Lawlor, Debbie A., Relton, Caroline L., Snieder, Harold, and Felix, Janine F.

Published
2019

48. D8.2 - First report on biobank activities

Author

Berglund, Marika, Bergstrom, Anna, Laguzzi, Federica, Leander, Karin, and Akesson, Agneta

Subjects
chemical exposure, metabolites, DEMOCOPHES, bisphenols, phthalates
Abstract

The overall aim of the this task in the HBM4EU project is to investigate data sources and gaps for the purposes of evaluating time trends in chemical exposure across Europe. The exposure data spans three time periods, two age groups and the 4 EU geographical areas. This report focuses on chemicals that can be analysed in urine, specifically DINCH.

Published
2018
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49. Sex-specific incidence of asthma, rhinitis and respiratory multimorbidity before and after puberty onset: individual participant meta-analysis of five birth cohorts collaborating in MeDALL

Author

Hohmann, Cynthia, primary, Keller, Theresa, additional, Gehring, Ulrike, additional, Wijga, Alet, additional, Standl, Marie, additional, Kull, Inger, additional, Bergstrom, Anna, additional, Lehmann, Irina, additional, Berg, Andrea von, additional, Heinrich, Joachim, additional, Lau, Susanne, additional, Wahn, Ulrich, additional, Maier, Dieter, additional, Anto, Josep, additional, Bousquet, Jean, additional, Smit, Henriette, additional, Keil, Thomas, additional, and Roll, Stephanie, additional

Published
2019
Full Text
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