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1. Osimertinib treatment based on plasma T790M monitoring in patients with EGFR-mutant non-small-cell lung cancer (NSCLC): EORTC Lung Cancer Group 1613 APPLE phase II randomized clinical trial

Author

Remon, J., Besse, B., Aix, S. Ponce, Callejo, A., Al-Rabi, K., Bernabe, R., Greillier, L., Majem, M., Reguart, N., Monnet, I., Cousin, S., Garrido, P., Robinet, G., Garcia Campelo, R., Madroszyk, A., Mazières, J., Curcio, H., Wasąg, B., Pretzenbacher, Y., Fournier, B., Dingemans, A.-M.C., and Dziadziuszko, R.

Published
2023
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3. A randomised phase II study of osimertinib and bevacizumab versus osimertinib alone as second-line targeted treatment in advanced NSCLC with confirmed EGFR and acquired T790M mutations: the European Thoracic Oncology Platform (ETOP 10-16) BOOSTER trial

Author

Stahel, Rolf, Peters, Solange, Soo, Ross, Han, Ji-Youn, Früh, Martin, Provencio, Mariano, Coate, Linda, Dafni, Urania, Hiltbrunner, Anita, Ruepp, Barbara, Roschitzki-Voser, Heidi, Gasca-Ruchti, Adriana, Giacomelli, Nino, Kammler, Rosita, Marti, Nesa, Nobs, Lionel, Pardo-Contreras, Mariana, Pfister, Rita, Piguet, Anne-Christine, Ribeli-Hofmann, Sabrina, Martinez, Virginia Rodriguez, Roux, Susanne, Sanchez-Hohl, Magdalena, Schneider, Mirjam, Schweri, Robin, Troesch, Sandra, Zigomo, Isabel, Tsourti, Zoi, Zygoura, Panagiota, Kassapian, Marie, Vervita, Katerina, Dimopoulou, Georgia, Andriakopoulou, Charitini, Fernandez, Maria, Pereira, Eva, Simona, Carolina, Tucker, Lisa, Burnes, Jillian, Barrett, Aisling, McGrillen, Meghan, Berset, Catherine, Biaggi, Christine, Reist, Martin, Rentsch, Priska, Cuffe, Sinead, Hashemi, Sayed, Nadal, Ernest, Carcereny, Enric, de Castro, Javier, Sala, Maria Angeles, Reyes, Bernabé, Pulla, Mariano Provencio, Campelo, Rosario Garcia, Massutí, Bartomeu, Garcia, Jose, Dómine, Manuel, Majem, Margarita, Sanchez, Jose Miguel, Britschgi, Christian, Pless, Miklos, Yeo, Chong Ming, Cho, Byoung Chul, Soo, R.A., Han, J.-Y., Dafni, U., Cho, B.C., Yeo, C.M., Nadal, E., Carcereny, E., de Castro, J., Sala, M.A., Bernabé, R., Coate, L., Provencio Pulla, M., Garcia Campelo, R., Cuffe, S., Hashemi, S.M.S., Früh, M., Massuti, B., Garcia-Sanchez, J., Dómine, M., Majem, M., Sanchez-Torres, J.-M., Britschgi, C., Pless, M., Dimopoulou, G., Roschitzki-Voser, H., Ruepp, B., Rosell, R., Stahel, R.A., and Peters, S.

Published
2022
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5. Clinical utility of plasma-based digital next-generation sequencing in patients with advance-stage lung adenocarcinomas with insufficient tumor samples for tissue genotyping

Author

Zugazagoitia, J., Ramos, I., Trigo, J.M., Palka, M., Gómez-Rueda, A., Jantus-Lewintre, E., Camps, C., Isla, D., Iranzo, P., Ponce-Aix, S., García-Campelo, R., Provencio, M., Franco, F., Bernabé, R., Juan-Vidal, O., Felip, E., de Castro, J., Sanchez-Torres, J.M., Faul, I., Lanman, R.B., Garrido, P., and Paz-Ares, L.

Published
2019
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6. Two biomarker-directed randomized trials in European and Chinese patients with nonsmall-cell lung cancer: the BRCA1-RAP80 Expression Customization (BREC) studies

Author

Moran, T., Wei, J., Cobo, M., Qian, X., Domine, M., Zou, Z., Bover, I., Wang, L., Provencio, M., Yu, L., Chaib, I., You, C., Massuti, B., Song, Y., Vergnenegre, A., Lu, H., Lopez-Vivanco, G., Hu, W., Robinet, G., Yan, J., Insa, A., Xu, X., Majem, M., Chen, X., de las Peñas, R., Karachaliou, N., Sala, M.A., Wu, Q., Isla, D., Zhou, Y., Baize, N., Zhang, F., Garde, J., Germonpre, P., Rauh, S., ALHusaini, H., Sanchez-Ronco, M., Drozdowskyj, A., Sanchez, J.J., Camps, C., Liu, B., Rosell, R., Colinet, B., De Grève, J., Germonpré, P., Chen, H., Du, J., Gao, Y., Hu, J., Kong, W., Li, L., Li, R., Li, X., Liu, J., Ren, W., Wen, L., Xiao, X., Yang, J., Yang, M., Yang, Y., Yin, J., Yue, X., Zhang, J., Zhu, L., Bombaron, P., Chouaid, C., Dansin, E., Fournel, P., Fraboulet, G., Gervais, R., Hominal, S., Kahlout, S., Lecaer, H., Lena, H., LeTreut, J., Locher, C., Molinier, O., Monnet, I., Oliviero, G., Schoot, R., Thomas, P., Vergnènegre, A., Berchem, G., Al Husaini, H., Aparisi, F., Arriola, E., Ballesteros, I., Barneto, I., Bernabé, R., Blasco, A., Bosch-Barrera, J., Calvo de Juan, V., Carcereny, E., Catot, S., De las Peñas, R., Dómine, M., Felip, E., García-Campelo, M.R., García-Girón, C., García-Gómez, R., Garcia-Sevila, R., Gasco, A., Gil, J., González-Larriba, J.L., Hernando-Polo, S., Jantus, E., Jiménez, B., Lianes, P., López-López, R., López-Martín, A., López-Vivanco, G., Macias, J.A., Marti-Ciriquian, J.L., Montoyo, R., Morales-Espinosa, D., Morán, T., Moreno, M.A., Pallares, C., Parera, M., Pérez-Carrión, R., Porta, R., Reguart, N., Rosillo, F., Sanchez, J.M., Sullivan, I., Terrasa, J., Trigo, J.M., Valdivia, J., Viñolas, N., Viteri, S., Botia-Castillo, M., Mate, J.L., Perez-Cano, M., Ramirez, J.L., Sanchez-Rodriguez, B., Taron, M., Tierno-Garcia, M., Mijangos, E., Ocaña, J., Pereira, E., Shao, J., Sun, X., and O'Brate, R.

Published
2014
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9. EP.06G.20 Advanced Squamous Cell Lung Carcinoma in Never Smokers: A Different Entity? Analysis from the Thoracic Tumor Registry in Spain (RTT)

Author

Blanco, M., Collazo-Lorduy, A., Cobo, M., Calvo, V., Martínez- Cutillas, M., Cantero, A., Rodríguez-Abreu, D., Carcereny, E., Bosch-Barrera, J., García Campelo, M.R., López Castro, R., Bernabé, R., del Barco, E., Ortega, A.L., Sánchez, A., Aparisi-Aparisi, F., Vázquez, S., Guirado, M., Casal, J., Medina, K., Cerezo, S., Camps, C., Gonzalez-Larriba, J.L., Sala, M.A., Massutí, B., Dómine, M., Losada, B., Royuela, A., and Provencio, M.

Published
2024
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11. HMGB1 Expression Levels Correlate with Response to Immunotherapy in Non-Small Cell Lung Cancer

Author

González-Cao M, Cai X, Bracht JWP, Han X, Yang Y, Pedraz-Valdunciel C, Morán T, García-Corbacho J, Aguilar A, Bernabé R, De Marchi P, Sussuchi da Silva L, Leal LF, Reis RM, Codony-Servat J, Jantus-Lewintre E, Molina-Vila MA, Cao P, and Rosell R

Subjects
hmgb1, immunotherapy, non-small cell lung cancer, lewis lung cancer murine model, k-ras mutations, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Maria González-Cao,1 Xueting Cai,2 Jilian Wilhelmina Paulina Bracht,3 Xuan Han,2 Yang Yang,2 Carlos Pedraz-Valdunciel,4 Teresa Morán,5 Javier García-Corbacho,6 Andrés Aguilar,1 Reyes Bernabé,7 Pedro De Marchi,8,9 Luciane Sussuchi da Silva,8 Leticia Ferro Leal,8 Rui Manuel Reis,8,10,11 Jordi Codony-Servat,4 Eloisa Jantus-Lewintre,12– 14 Miguel Angel Molina-Vila,4 Peng Cao,2,15 Rafael Rosell1,16 1Translational Cancer Research Unit, Instituto Oncológico Dr Rosell, Dexeus University Hospital, Barcelona, Spain; 2Integrated Traditional Chinese and Western Medicine Department of Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 3Amsterdam University Medical Center (UMC), Amsterdam, The Netherlands; 4Laboratory of Oncology, Pangaea Oncology, Quirón Dexeus University Hospital, Barcelona, Spain; 5Medical Oncology Department, Catalan Institute of Oncology (ICO), Germans Trias i Pujol Hospital, Badalona, Spain; 6Medical Oncology Department (Hospital Clinic)/Translational Genomics and Targeted Therapies in Solid Tumors (IDIBAPs), Barcelona, Spain; 7Medical Oncology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain; 8Molecular Oncology Research Center; Barretos Cancer Hospital, Barretos, Brazil; 9Oncoclinicas, Rio de Janeiro, Brazil; 10Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; 11ICVS/3b’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal; 12Valencian Community Foundation Principe Felipe Research Center, Laboratory of Molecular Oncology, Valencia, Spain; 13Centro de Investigación Biomédica en Red (CIBERONC), Madrid, Spain; 14Universitat Politècnica de Valencia, Biotechnology Department, Valencia, Spain; 15College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 16Laboratory of Molecular Biology, Germans Trias i Pujol Health Sciences Institute and Hospital (IGTP), Badalona, SpainCorrespondence: Rafael Rosell, Laboratory of Molecular Biology, Germans Trias i Pujol Health Sciences Institute and Hospital (IGTP), Camí de les Escoless/n, Badalona, Barcelona, 08916, Spain, Tel +34 930330520, Email rrosell@iconcologia.net Peng Cao, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China, Tel +86 85608666, Email cao_peng@njucm.edu.cnPurpose: High-mobility group box 1 protein (HMGB1) is subject to exportin 1 (XPO1)-dependent nuclear export, and it is involved in functions implicated in resistance to immunotherapy. We investigated whether HMGB1 mRNA expression was associated with response to immune checkpoint inhibitors (ICI) in non-small cell lung cancer (NSCLC).Patients and Methods: RNA was isolated from pretreatment biopsies of patients with advanced NSCLC treated with ICI. Gene expression analysis of several genes, including HMGB1, was conducted using the NanoString Counter analysis system (PanCancer Immune Profiling Panel). Western blotting analysis and cell viability assays in EGFR and KRAS mutant cell lines were carried out. Evaluation of the antitumoral effect of ICI in combination with XPO1 blocker (selinexor) and trametinib was determined in a murine Lewis lung carcinoma model.Results: HMGB1 mRNA levels in NSCLC patients treated with ICI correlated with progression-free survival (PFS) (median PFS 9.0 versus 18.0 months, P=0.008, hazard ratio=0.30 in high versus low HMGB1). After TNF-α stimulation, HMGB1 accumulates in the cytoplasm of PC9 cells, but this accumulation can be prevented by using selinexor or antiretroviral drugs. Erlotinib or osimertinib with selinexor in EGFR-mutant cells and trametinib plus selinexor in KRAS mutant abolish tumor cell proliferation. Selinexor with a PD-1 inhibitor with or without trametinib abrogates the tumor growth in the murine Lewis lung cancer model.Conclusion: An in-depth exploration of the functions of HMGB1 mRNA and protein is expected to uncover new potential targets and provide a basis for treating metastatic NSCLC in combination with ICI.Keywords: HMGB1, immunotherapy, non-small cell lung cancer, Lewis lung cancer murine model, K-Ras mutations

Published
2024

12. VP3-2021: A randomized phase II study of second-line osimertinib (Osi) and bevacizumab (Bev) versus Osi in advanced non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) and T790M mutations (mt): Results from the ETOP BOOSTER trial

Author

Soo, R., Han, J-Y., Dimopoulou, G., Cho, B.C., Yeo, C.M., Nadal, E., Carcereny, E., de Castro, J., Sala, M.A., Bernabe, R., Coate, L., Provencio, M., Campelo, R. Garcia, Cuffe, S., Hashemi, S., Früh, M., Ruepp, B., Roschitzki-Voser, H., Stahel, R., and Peters, S.

Published
2021
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14. P1.27-07 BRAF Mutations Identify Non-small-Cell Lung Cancer Patients Who Benefit from Neoadjuvant Chemo-Immunotherapy

Author

Robado de Lope, L., Nadal, E., Calvo, V., González-Larriba, J.L., Insa, A., Martinez-Marti, A., Massutí, B., González, C., Serna Blasco, R., Bosch-Barrera, J., Garcia-Campelo, M.R., Ponce, S., Reguart, N., Bernabé, R., Cobo, M., De Castro, J., Dómine, M., Camps, C., Barneto, I., López-Vivanco, G., Majem, M., Rodríguez-Abreu, D., Palmero, R., Cruz-Bermudez, A., Romero, A., and Provencio, M.

Published
2023
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15. MA16.04 Circulating Tumor DNA Quantification by NGS Should Be Adapted to the Methodology Used

Author

Serna Blasco, R., Nadal, E., Calvo, V., Gonzalez-Larriba, J.L., Insa, A., Massutí, B., Garcia-Campelo, M.R., Martinez-Marti, A., Casal, J., Garrido Fernandez, A., Bosch-Barrera, J., Dómine, M., De Castro, J., Ponce, S., Majem, M., Rodriguez-Abreu, D., Reguart, N., Bernabé, R., Barneto, I., Cobo, M., Camps, C., López Vivanco, G., Del Barco, E., Aguilar, A., Moran, T., Lopez-Castro, R., Cruz-Bermúdez, A., Romero, A., and Provencio, M.

Published
2023
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20. Untangling adaptive functioning of PMM2-CDG across age and its impact on parental stress: a cross-sectional study

Author

Florencia Epifani, Susana María Pujol Serra, Marta Llorens, Sol Balcells, Gregorio Nolasco, Mercè Bolasell, Sergio Aguilera-Albesa, Ramon Cancho Candela, José Luis Cuevas Cervera, Verónica García Sánchez, Oscar Garcia, María Concepción Miranda-Herrero, Pedro J. Moreno-Lozano, Bernabé Robles, Susana Roldán Aparicio, Ramón Velázquez Fragua, and Mercedes Serrano

Subjects
Medicine, Science
Abstract

Abstract Phosphomannomutase deficiency (PMM2-CDG) leads to cerebellar atrophy with ataxia, dysmetria, and intellectual deficits. Despite advances in therapy, the cognitive and adaptive profile remains unknown. Our study explores the adaptive profile of 37 PMM2-CDG patients, examining its association with parental stress and medical characteristics. Assessment tools included ICARS for the cerebellar syndrome and NPCRS for global disease severity. Behavioral and adaptive evaluation consisted of the Vineland Adaptive Behavior Scale and the Health of the Nation Outcome Scales. Psychopathological screening involved the Child Behavior Checklist and the Symptom Check-List-90-R. Parental stress was evaluated using Parental Stress Index. Results were correlated with clinical features. No significant age or sex differences were found. ‘Daily living skills’ were notably affected. Patients severely affected exhibited lower adaptive skill values, as did those with lipodystrophy and inverted nipples. Greater severity in motor cerebellar syndrome, behavioral disturbances and the presence of comorbidities such as hyperactivity, autistic features and moderate-to-severe intellectual disability correlated with greater parental stress. Our study found no decline in adaptive abilities. We provide tools to assess adaptive deficits in PMM2-CDG patients, emphasizing the importance of addressing communication, daily living skills, and autonomy, and their impact on parental stress in clinical monitoring and future therapies.

Published
2023
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21. Inhibition of the Growth of Escherichia coli and Staphylococcus aureus Microorganisms in Aesthetic Orthodontic Brackets through the In Situ Synthesis of Ag, TiO2 and Ag/TiO2 Nanoparticles

Author

Paola Ariselda Sánchez Reyna, Oscar Fernando Olea Mejía, María G. González-Pedroza, Norma M. Montiel-Bastida, Bernabe Rebollo-Plata, and Raúl A. Morales-Luckie

Subjects
Ag, TiO2 and Ag/TiO2 nanoparticles, aesthetic orthodontic brackets of α-alumina, antibacterial effect, Biology (General), QH301-705.5
Abstract

Plaque control is especially important during orthodontic treatment because areas of the teeth near brackets and wires are difficult to clean with a toothbrush, resulting in debris buildup of food or dental plaque, thus causing caries and periodontal disease. The objective of this study was to evaluate the antimicrobial properties of silver nanoparticles (AgNPs), titanium dioxide nanoparticles (TiO2NPs), and silver/titanium dioxide nanoparticles (Ag/TiO2NPs), synthesized on the surface of α-alumina ceramic brackets. The AgNPs and TiO2NPs were synthesized by a simple chemical method, and these were characterized by XRD, SEM, and XPS TEM; the antimicrobial activity was tested against Staphylococcus aureus and Escherichia coli by diffusion test. The results of this study demonstrated that by this simple chemical method, silver and titanium dioxide nanoparticles can be synthesized on the surface of α-alumina esthetic brackets, and these NPs possess good antimicrobial activity and the possibility of reducing dental caries, periodontal disease, and white spot generated during orthodontic treatment.

Published
2024
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22. MA06.03 Pre-treatment ctDNA Levels Significantly Predicts of OS and PFS in NADIM II Trial

Author

Romero, A., Serna, R., Nadal, E., Larriba, J.L. Glez, Martínez-Martí, A., Bernabé, R., Bosch-Barrera, J., Fernandez, A. Garrido, Calvo, V., Insa, A., Ponce, S., Reguart, N., De Castro, J., Massutí, B., Palmero, R., Aguado de la Rosa, C., Mosquera, J., Cobo, M., Aguilar, A., Vivanco, G. López, Camps, C., Trancho, F. Hernando, Castro, R. Lopez, Moran, T., Barneto, I., Rodríguez-Abreu, D., Cruz, A., and Provencio, M.

Published
2022
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23. OA02.03 Tumor Bulk-RNA Seq Identifies Patients at High Risk of Progression in Non-complete Pathological Responders from NADIM Trial

Author

Casarrubios, M., Cruz-Bermúdez, A., Sierra-Rodero, B., Martinez, C., Nadal, E., Calvo, V., Insa, A., García- Campelo, M.d.R., Gonzalez Ojea, C., Dómine, M., Majem, M., Rodríguez-Abreu, D., Martínez-Martí, A., De Castro Carpeño, J., Cobo, M., López-Vivanco, G., Del Barco, E., Bernabé, R., Massutí, B., and Provencio, M.

Published
2022
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24. PL03.12 Progression Free Survival and Overall Survival in NADIM II Study

Author

Provencio, M., Serna, R., Nadal, E., Glez Larriba, J.L., Martínez-Martí, A., Bernabé, R., Bosch-Barrera, J., Garcia Benito, C., Calvo, V., Insa, A., Ponce, S., Reguart, N., De Castro, J., Massutí, B., Palmero, R., Aguado de la Rosa, C., Mosquera, J., Cobo, M., Aguilar, A., López Vivanco, G., Camps, C., Hernando Trancho, F., López Castro, R., Moran, T., Barneto, I., Rodríguez-Abreu, D., and Romero, A.

Published
2022
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28. OA20.01 Long Term Survival in Operable Stage Iiia Nsclc Patients Treated With Neoadjuvant Nivolumab Plus Chemotherapy - Nadim Study

Author

Provencio, M., Nadal, E., Insa, A., Campelo, M.R. García, Pereiro, D., Domine, M., Majem, M., Abreu, D. Rodriguez, Martinez-Marti, A., De Castro, J., Cobo, M., Vivanco, G. López, Del Barco, E., Bernabé, R., Viñolas, N., Barneto, I., Viteri, S., Pereira, E., Royuela, A., Casarrubios, M., Salas, C., Parra, E.R., Wistuba, I., Calvo, V., Laza - Briviesca, R., Romero, A., Massuti, B., and Cruz, A.

Published
2021
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29. OA20.02 Pre-Treatment Levels of ctDNA for Long-Term Survival Prediction in Stage IIIA NSCLC Treated With Neoadjuvant Chemo-Immunotherapy

Author

Romero, A., Nadal, E., Serna, R., Insa, A., Campelo, M.R. García, Benito, C., Domine, M., Majem, M., Abreu, D. Rodriguez, Martinez-Marti, A., De Castro, J., Cobo, M., Vivanco, G. López, Del Barco, E., Bernabé, R., Viñolas, N., Barneto, I., Viteri, S., Pereira, E., Royuela, A., Casarrubios, M., Calvo, V., Laza - Briviesca, R., Massuti, B., Cruz, A., Sánchez-Herrero, E., and Provencio, M.

Published
2021
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30. OA14.01 Family History of Cancer and Lung Cancer: Information from the Thoracic Tumors Registry (TTR Study)

Author

Calvo, V., Carcereny, E., Abreu, D. Rodriguez, Lopez-Castro, R., Guirado, M., Camps, C., Cobo, M., Ortega, A.L., Bernabé, R., Massuti, B., Mosquera, J., Del Barco, E., Gonzalez - Larriba, J.L., Bosch - Barrera, J., Ojeda, C. Gonzalez, Domine, M., Juan, O., Martínez-Cutillas, M., Benítez, G., Collazo-Lorduy, A., Cucurull, M., and Provencio, M.

Published
2021
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34. 1275P Extended follow-up of DURVAST trial: A phase II study evaluating durvalumab treatment in HIV-1-infected patients with solid tumours by the Spanish lung cancer group

Author

Cao, M. Gonzalez, Moran, T., Dalmau, J., Garcia-Corbacho, J., Bernabe, R., Vidal, O.J. Juan, de Castro Carpeño, J., Blanco, R., Drozdowskyj, A., Meyerhans, A., Blanco, J., Prado, J.G., Clotet, B., Sureda, B. Massuti, Pulla, M. Provencio, Molina-Vila, M.A., Martinez-Picado, J., and Costa, R. Rosell

Published
2020
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35. P2.10-02 Smoking Habit in Lung Cancer in Spain

Author

Carcereny, E., Franco, F., Rodriguez-Abreu, D., Castro, R. Lopez, De Las Penas, R., Guirado, M., Camps, C., Bosch-Barrera, J., Campelo, R. Garcia, Ortega, A.L., Gonzalez-Larriba, J.L., Huidobro, G., Domine, M., Massuti, B., Sala, M.a., Bernabe, R., Oramas, J., Del Barco, E., De Castro Carpeno, J., Padilla, A., Aguiar, D., Cerezo, S., Blanco, R., Albite, E. Cuadrado, Benitez, G., Domenech, M., and Provencio, M.

Published
2019
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36. P2.05-12 Analysis of Biomarkers in Lung Cancer in Spain

Author

Rodriguez-Abreu, D., Moran, T., Castro, R. Lopez, Guirado, M., Camps, C., Nunez, B., Bosch-Barrera, J., Bernabe, R., Lazaro, M., Campelo, R. Garcia, Larriba, J.L. Gonzalez, Massuti, B., Ortega, A.L., Domine, M., Sala, M.a., Padilla, A., Del Barco, E., Oramas, J., Blanco, R., Estival, A., Benitez, G., and Provencio, M.

Published
2019
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37. P2.04-10 Biomarkers of Pathological Response on Neo-Adjuvant Chemo-Immunotherapy Treatment for Resectable Stage IIIA NSCLC Patients

Author

Laza-Briviesca, R., Cruz-Bermudez, A., Casarrubios, M., Nadal, E., Insa, A., Campelo, R. Garcia, De Dios Alvarez, N., Domine, M., Majem, M., Rodriguez-Abreu, D., De Juan, V. Calvo, Martinez-Marti, A., De Castro Carpeno, J., Cobo, M., López-Vivanco, G., Del Barco, E., Bernabe, R., Viñolas, N., Barneto, I., Viteri, S., Massuti, B., and Provencio, M.

Published
2019
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38. P2.03-16 Agreement Between Different Methodologies for Non-Invasive p.T790M and EGFR Sensitizing Mutation Testing

Author

Romero, A., Jantus, E., Molina-Vila, M.A., Insa, A., Cruz, P., Collazo, A., Altozano, J. Perez, Juan, O., Diz, P., Cobo, M., Hernandez, B., Vazquez, S., Benitez, G., Guirado, M., Majem, M., Bernabe, R., Ortega, A.L., Blasco, A., Bosch-Barrera, J., Jurado, J.M., Garcia, J., Viteri, S., Giron, C. Garcia, Massuti, B., Martin, A. Lopez, Garcia-Pelaez, B., Aparisi, F., Romero, E. Sánchez, Festa, A. Rodríguez, Calabuig-Fariñas, S., Rosell, R., Camps, C., and Provencio, M.

Published
2019
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41. OA13.05 NADIM Study: Updated Clinical Research and Outcomes

Author

Provencio, M., Nadal, E., Insa, A., Campelo, R. Garcia, Casal, J., Domine, M., Majem, M., Rodriguez-Abreu, D., Martinez-Marti, A., De Castro Carpeno, J., Cobo, M., López-Vivanco, G., Del Barco, E., Bernabe, R., Viñolas, N., Barneto, I., Viteri, S., Martorell, P. Martin, Jove, M., De Juan, V. Calvo, and Massuti, B.

Published
2019
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43. 1845P - Tobacco use in lung cancer (LC) patients (p) in Spain

Author

Carcereny Costa, E., Guirado, M., Camps Herrero, C.J., Bosch Barrera, J., García-Campelo, M.-R., Ortega Granados, A.L., Gonzalez-Larriba, J.L., De Dios Alvare, N., Domine Gomez, M., Massuti Sureda, B., Sala, M.A., Bernabé, R., Oramas Rodriguez, J.M., del Barco Morillo, E., Padilla, A., Aguiar Bujanda, D., Cerezo Gonzalez, S., Lopez Castro, R., Rodriguez Abreu, D., and Provencio, M.

Published
2019
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44. 1846P - Biomarker testing of lung cancer in Spain

Author

Rodriguez Abreu, D., Guirado, M., Camps Herrero, C.J., Bosch Barrera, J., Bernabé, R., Casal, J., García-Campelo, M.-R., Gonzalez-Larriba, J.L., Massuti Sureda, B., Ortega Granados, A.L., Domine Gomez, M., Sala, M.A., Padilla, A., Del Barco Morillo, E., Oramas Rodriguez, J.M., Blanco Guerrero, R., Aguiar Bujanda, D., López Castro, R., Carcereny Costa, E., and Provencio, M.

Published
2019
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46. 1241P - Immune cell biomarkers on neo-adjuvant chemo-immunotherapy treatment for resectable stage IIIA NSCLC patients

Author

Laza-Briviesca, R., Cruz-Bermudez, A., Casarrubios, M., Nadal, E., Molla, M A Insa, García-Campelo, M.-R., Huidobro, G., Gomez, M Domine, Tarruella, M Majem, Abreu, D Rodriguez, Martinez-Marti, A., De Carpeno, JCastro, Dols, M Cobo, Vivanco, G López, del Barco Morillo, E., Bernabé, R., Viñolas, N., Aranda, I C Barneto, Sureda, B Massuti, and Provencio, M.

Published
2019
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50. La formación del personal de mantenimiento para la industria 4.0

Author

Patricia Avitia-Carlos, Alex Bernardo Pimentel-Mendoza, José Luis Rodríguez-Verduzco, and Bernabé Rodríguez-Tapia

Subjects
Industria 4.0, formación técnica, mantenimiento industrial, Engineering (General). Civil engineering (General), TA1-2040, Technology (General), T1-995
Abstract

La industria 4.0 (I4.0) se caracteriza por la incorporación de tecnologías digitales a los procesos de manufactura, dotándolos de flexibilidad y capacidad de adaptación en tiempo real. El desarrollo de este tipo de industria se considera un factor competitivo a nivel mundial. Sin embargo, el sostenimiento de la I4.0 requiere la presencia de personal técnico competente capaz de llevar a cabo tareas de mejora y mantenimiento a sistemas de manufactura de alta digitalización. La zona conurbada de Tijuana-Tecate alberga industria manufacturera de los sectores electrónico, biomédico y aeroespacial, entre otros. La presencia de esta industria es fundamental dentro de las actividades económicas de la región. El objetivo del trabajo consistió en identificar las necesidades de formación asociadas al ejercicio efectivo de actividades de mantenimiento del personal técnico y de ingeniería que labora en empresas locales; así como las estrategias que éstas siguen para reentrenar y actualizar a dicho personal. En el presente trabajo de corte exploratorio, se realiza una revisión documental en cuanto a las habilidades técnicas requeridas para el desarrollo y sostenimiento de Industria 4.0, seguida de una entrevista semiestructurada a cinco miembros de la industria local responsables de áreas de mantenimiento industrial. El instrumento indagó dimensiones como tecnologías 4.0 empleadas, disponibilidad local de personal cualificado, competencias requeridas, esquemas internos de formación y estrategias para la retención y desarrollo del personal. A partir de los resultados puede observarse que las empresas entrevistadas no realizan colaboraciones con los programas educativos formales para atender las necesidades de capacitación y actualización del sector. Se identifica además un retraso en la implementación de tecnologías de industria 4.0 en la industria local y la predominancia de modelos tradicionales de mantenimiento, ya que solamente una empresa reporta el empleo de mantenimiento basado en la confiabilidad. El trabajo futuro consiste en ampliar el estudio enfocándolo en un solo sector de la industria de manufactura y realizando entrevistas a profundidad encaminadas al diseño de actividades conjuntas industria-academia para el registro de estándares de formación que deriven en la certificación de competencias específicas.

Published
2022
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