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1. One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial

Author

Díez-Ricote, Laura, San-Cristobal, Rodrigo, Concejo, M José, Martínez-González, Miguel Á, Corella, Dolores, Salas-Salvadó, Jordi, Goday, Albert, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A, Martín Sánchez, Vicente, Pintó, Xavier, Gaforio, José J, Matía-Martín, Pilar, Vidal, Josep, Mas Fontao, Sebastián, Ros, Emilio, Vázquez-Ruiz, Zenaida, Ortega-Azorín, Carolina, García-Gavilán, Jesús F, Malcampo, Mireia, Martínez-Urbistondo, Diego, Tojal-Sierra, Lucas, García Rodríguez, Antonio, Gómez-Bellvert, Nuria, Chaplin, Alice, García-Ríos, Antonio, Bernal-López, Rosa M, Santos-Lozano, José M, Basterra-Gortari, Javier, Sorlí, José V, Murphy, Michelle, Gasulla, Griselda, Micó, Víctor, Salaverria-Lete, Itziar, Goñi Ochandorena, Estibaliz, Babio, Nancy, Herraiz, Xavier, Ordovás, José M, and Daimiel, Lidia

Published
2022
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2. Factors associated with successful dietary changes in an energy-reduced Mediterranean diet intervention: a longitudinal analysis in the PREDIMED-Plus trial

Author

Fernandez-Lazaro, Cesar I., Toledo, Estefanía, Buil-Cosiales, Pilar, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Ros, Emilio, Vázquez, Clotilde, Daimiel, Lidia, SanJulián, Beatriz, García-Gavilán, Jesús F., Sorlí, Jose V., Castañer, Olga, Zulet, M. Ángeles, Tojal-Sierra, Lucas, Pérez-Farinós, Napoleón, Oncina-Canovas, Alejandro, Moñino, Manuel, Garcia-Rios, Antonio, Sacanella, Emilio, Bernal-Lopez, Rosa M., Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Muralidharan, Jananee, Ortega-Azorín, Carolina, Goday, Alberto, Razquin, Cristina, Goicolea-Güemez, Leire, Ruiz-Canela, Miguel, Becerra-Tomás, Nerea, Schröder, Helmut, and Martínez González, Miguel A.

Published
2022
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3. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author

Oncina-Cánovas, Alejandro, Vioque, Jesús, González-Palacios, Sandra, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño, Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Bernal-Lopez, Rosa M., Lapetra, José, Serra-Majem, J. Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Toledo, Estefanía, Babio, Nancy, Sorli, Jose V., Schröder, Helmut, Zulet, María Angeles, Sorto-Sánchez, Carolina, Barón-López, Francisco Javier, Compañ-Gabucio, Laura, Morey, Marga, García-Ríos, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Nishi, Stephanie K., Asensio, Eva M., Soldevila, Núria, Abete, Itziar, Goicolea-Güemez, Leire, Buil-Cosiales, Pilar, García-Gavilán, Jesús F., Canals, Erik, Torres-Collado, Laura, and García-de-la-Hera, Manuela

Published
2022
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5. The Effect of Sex and Obesity on the Gene Expression of Lipid Flippases in Adipose Tissue

Author

Motahari-Rad, Hanieh, primary, Subiri, Alba, additional, Soler, Rocio, additional, Ocaña, Luis, additional, Alcaide, Juan, additional, Rodríguez-Capitan, Jorge, additional, Buil, Veronica, additional, Azzouzi, Hamid el, additional, Ortega-Gomez, Almudena, additional, Bernal-Lopez, Rosa, additional, Insenser, Maria, additional, Tinahones, Francisco J., additional, and Murri, Mora, additional

Published
2022
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6. The Effect of Sex and Obesity on the Gene Expression of Lipid Flippases in Adipose Tissue

Author

Motahari-Rad, Hanieh, Subiri, Alba, Soler, Rocio, Ocaña, Luis, Alcaide, Juan, Rodríguez-Capitan, Jorge, Buil, Veronica, Azzouzi, Hamid El, Ortega-Gomez, Almudena, Bernal-Lopez, Rosa, Insenser, Maria, Tinahones, Francisco J., Murri, Mora, Motahari-Rad, Hanieh, Subiri, Alba, Soler, Rocio, Ocaña, Luis, Alcaide, Juan, Rodríguez-Capitan, Jorge, Buil, Veronica, Azzouzi, Hamid El, Ortega-Gomez, Almudena, Bernal-Lopez, Rosa, Insenser, Maria, Tinahones, Francisco J., and Murri, Mora

Abstract

Molecular mechanisms behind obesity and sex-related effects in adipose tissue remain elusive. During adipocyte expansion, adipocytes undergo drastic remodelling of lipid membrane compositions. Lipid flippases catalyse phospholipid translocation from exoplasmic to the cytoplasmic leaflet of membranes. The present study aimed to analyse the effect of sex, obesity, and their interactions on the gene expression of two lipid flippases—ATP8A1 and ATP8B1—and their possible microRNA (miR) modulators in visceral adipose tissue (VAT). In total, 12 normal-weight subjects (5 premenopausal women and 7 men) and 13 morbidly obese patients (7 premenopausal women and 6 men) were submitted to surgery, and VAT samples were obtained. Gene expression levels of ATP8A1, ATP8B1, miR-548b-5p, and miR-4643 were measured in VAT. Our results showed a marked influence of obesity on VAT ATP8A1 and ATP8B1, although the effects of obesity were stronger in men for ATP8A1. Both genes positively correlated with obesity and metabolic markers. Furthermore, ATP8B1 was positively associated with miR-548b-5p and negatively associated with miR-4643. Both miRs were also affected by sex. Thus, lipid flippases are altered by obesity in VAT in a sex-specific manner. Our study provides a better understanding of the sex-specific molecular mechanisms underlying obesity, which may contribute to the development of sex-based precision medicine.

Published
2022

7. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author

Universitat Rovira i Virgili, Oncina-Canovas, Alejandro; Vioque, Jesus; Gonzalez-Palacios, Sandra; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Zomeno, Dolores; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Bernal-Lopez, Rosa M.; Lapetra, Jose; Luis Serra-Majem, J.; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin-Sanchez, Vicente; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emili; Toledo, Estefania; Babio, Nancy; Sorli, Jose, V; Schroder, Helmut; Angeles Zulet, Maria; Sorto-Sanchez, Carolina; Javier Baron-Lopez, Francisco; Compan-Gabucio, Laura; Morey, Marga; Garcia-Rios, Antonio; Casas, Rosa; Maria Gomez-Perez, Ana; Manuel Santos-Lozano, Jose; Vazquez-Ruiz, Zenaida; Nishi, Stephanie K.; Asensio, Eva M.; Soldevila, Nuria; Abete, Itziar; Goicolea-Guemez, Leire; Buil-Cosiales, Pilar; Garcia-Gavilan, Jesus F.; Canals, Erik; Torres-Collado, Laura; Garcia-de-la-Hera, Manuela, Universitat Rovira i Virgili, and Oncina-Canovas, Alejandro; Vioque, Jesus; Gonzalez-Palacios, Sandra; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Zomeno, Dolores; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Bernal-Lopez, Rosa M.; Lapetra, Jose; Luis Serra-Majem, J.; Bueno-Cavanillas, Aurora; Tur, Josep A.; Martin-Sanchez, Vicente; Pinto, Xavier; Delgado-Rodriguez, Miguel; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emili; Toledo, Estefania; Babio, Nancy; Sorli, Jose, V; Schroder, Helmut; Angeles Zulet, Maria; Sorto-Sanchez, Carolina; Javier Baron-Lopez, Francisco; Compan-Gabucio, Laura; Morey, Marga; Garcia-Rios, Antonio; Casas, Rosa; Maria Gomez-Perez, Ana; Manuel Santos-Lozano, Jose; Vazquez-Ruiz, Zenaida; Nishi, Stephanie K.; Asensio, Eva M.; Soldevila, Nuria; Abete, Itziar; Goicolea-Guemez, Leire; Buil-Cosiales, Pilar; Garcia-Gavilan, Jesus F.; Canals, Erik; Torres-Collado, Laura; Garcia-de-la-Hera, Manuela

Abstract

Purpose We explored the cross-sectional association between the adherence to three different provegetarian (PVG) food patterns defined as general (gPVG), healthful (hPVG) and unhealthful (uPVG), and the cardiometabolic risk in adults with metabolic syndrome (MetS) of the PREDIMED-Plus randomized intervention study. Methods We performed a cross-sectional analysis of baseline data from 6439 participants of the PREDIMED-Plus randomized intervention study. The gPVG food pattern was built by positively scoring plant foods (vegetables/fruits/legumes/grains/potatoes/nuts/olive oil) and negatively scoring, animal foods (meat and meat products/animal fats/eggs/fish and seafood/dairy products). The hPVG and uPVG were generated from the gPVG by adding four new food groups (tea and coffee/fruit juices/sugar-sweetened beverages/sweets and desserts), splitting grains and potatoes and scoring them differently. Multivariable-adjusted robust linear regression using MM-type estimator was used to assess the association between PVG food patterns and the standardized Metabolic Syndrome score (MetS z-score), a composed index that has been previously used to ascertain the cardiometabolic risk, adjusting for potential confounders. Results A higher adherence to the gPVG and hPVG was associated with lower cardiometabolic risk in multivariable models. The regression coefficients for 5th vs. 1st quintile were - 0.16 (95% CI: - 0.33 to 0.01) for gPVG (p trend: 0.015), and - 0.23 (95% CI: - 0.41 to - 0.05) for hPVG (p trend: 0.016). In contrast, a higher adherence to the uPVG was associated with higher cardiometabolic risk, 0.21 (95% CI: 0.04 to 0.38) (p trend: 0.019). Conclusion Higher adherence to gPVG and hPVG food patterns was generally associated with lower cardiovascular risk, whereas higher a

Published
2022

9. Pro-vegetarian food patterns and cardiometabolic risk in the PREDIMED-Plus study: a cross-sectional baseline analysis

Author

Oncina-Cánovas, Alejandro, primary, Vioque, Jesús, additional, González-Palacios, Sandra, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Dolores, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Bernal-Lopez, Rosa M., additional, Lapetra, José, additional, Serra-Majem, J. Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín-Sánchez, Vicente, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emili, additional, Toledo, Estefanía, additional, Babio, Nancy, additional, Sorli, Jose V., additional, Schröder, Helmut, additional, Zulet, María Angeles, additional, Sorto-Sánchez, Carolina, additional, Barón-López, Francisco Javier, additional, Compañ-Gabucio, Laura, additional, Morey, Marga, additional, García-Ríos, Antonio, additional, Casas, Rosa, additional, Gómez-Pérez, Ana María, additional, Santos-Lozano, José Manuel, additional, Vázquez-Ruiz, Zenaida, additional, Nishi, Stephanie K., additional, Asensio, Eva M., additional, Soldevila, Núria, additional, Abete, Itziar, additional, Goicolea-Güemez, Leire, additional, Buil-Cosiales, Pilar, additional, García-Gavilán, Jesús F., additional, Canals, Erik, additional, Torres-Collado, Laura, additional, and García-de-la-Hera, Manuela, additional

Published
2021
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14. Metabolomics-Guided Insights on Bariatric Surgery Versus Behavioral Interventions for Weight Loss

Author

Tulipani, Sara, Griffin, Jules, Palau-Rodriguez, Magali, Mora-Cubillos, Ximena, Bernal-Lopez, Rosa M., Tinahones, Francisco J., Corkey, Barbara E., Andres-Lacueva, Cristina, [Tulipani, Sara] Univ Barcelona, Fac Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Biomarkers & Nutrimetabol Lab,XaRTA,INSA, Barcelona, Spain, [Palau-Rodriguez, Magali] Univ Barcelona, Fac Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Biomarkers & Nutrimetabol Lab,XaRTA,INSA, Barcelona, Spain, [Mora-Cubillos, Ximena] Univ Barcelona, Fac Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Biomarkers & Nutrimetabol Lab,XaRTA,INSA, Barcelona, Spain, [Andres-Lacueva, Cristina] Univ Barcelona, Fac Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Biomarkers & Nutrimetabol Lab,XaRTA,INSA, Barcelona, Spain, [Tulipani, Sara] Univ Malaga, Biomed Res Inst IBIMA, Serv Endocrinol & Nutr, Malaga Hosp Complex Virgen de la Victoria, Malaga, Spain, [Tinahones, Francisco J.] Univ Malaga, Biomed Res Inst IBIMA, Serv Endocrinol & Nutr, Malaga Hosp Complex Virgen de la Victoria, Malaga, Spain, [Griffin, Jules] MRC, Human Nutr Res, Elsie Widdowson Lab, Cambridge, England, [Griffin, Jules] Univ Cambridge, Dept Biochem, Cambridge, England, [Griffin, Jules] Univ Cambridge, Cambridge Syst Biol Ctr, Cambridge, England, [Bernal-Lopez, Rosa M.] Univ Malaga, Biomed Res Inst IBIMA, Serv Internal Med, Hosp Reg Univ Malaga, Malaga Hosp Complex, Malaga, Spain, [Bernal-Lopez, Rosa M.] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERobn, Madrid, Spain, [Tinahones, Francisco J.] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERobn, Madrid, Spain, [Corkey, Barbara E.] Boston Univ, Sch Med, Obes Res Ctr, Boston, MA 02118 USA, Project (Plan N de I+D+i), ISCII-Subdireccioen General de Evaluacion y Fomento de la Investigacion, Fondo Europeo de Desarrollo Regional (FEDER), Fundacion Progreso y Salud, Consejeria de Salud y Bienestar Social, Junta de Andalucia, FEDER, JPI HDHL FOODBALL Project, Generalitat de Catalunya's Agency, AGAUR, and Juan de la Cierva fellowship (MINECO)

Subjects
Randomized controlled-trial, Severely obese-patients, Plasma, Bile-acids, Amino-acid-metabolism, Y gastric bypass, Type-2 diabetes-mellitus, Induced insulin-resistance, Fatty-acid, Dietary supplementation
Abstract

Objective: To review the metabolomic studies carried out so far to identify metabolic markers associated with surgical and dietary treatments for weight loss in subjects with obesity.Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed.Results: Thirty-two studies successfully met the eligibility criteria. The metabolic adaptations shared by surgical and dietary interventions mirrored a state of starvation ketoacidosis (increase of circulating ketone bodies), an increase of acylcarnitines and fatty acid beta-oxidation, a decrease of specific amino acids including branched-chain amino acids (BCAA) and (lyso)glycerophospholipids previously associated with obesity, and adipose tissue expansion. The metabolic footprint of bariatric procedures was specifically characterized by an increase of bile acid circulating pools and a decrease of ceramide levels, a greater perioperative decline in BCAA, and the rise of circulating serine and glycine, mirroring glycemic control and inflammation improvement. In one study, 3-hydroxybutyrate was particularly identified as an early metabolic marker of long-term prognosis after surgery and proposed to increase current prognostic modalities and contribute to personalized treatment.Conclusions: Metabolomics helped in deciphering the metabolic response to weight loss treatments. Moving from association to causation is the next challenge to move to a further level of clinical application.

Published
2016

17. Educational Inequalities and Cardiovascular Risk Factors. A Cross-Sectional Population-Based Study in Southern Spain

Author

Morales-Asencio, José Miguel, primary, Mancera-Romero, José, additional, Bernal-Lopez, Rosa, additional, Martos-Cerezuela, Ildefonso, additional, Baca-Osorio, Antonio J., additional, Moyano-Paris, Maria Teresa, additional, Montiel-Murillo, Juana, additional, Juncosa, Flores Perez, additional, Perez, Rosa Sanchez, additional, Tinahones, Francisco J., additional, and Gomez-Huelgas, Ricardo, additional

Published
2012
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19. Alterations of specific biomarkers of metabolic pathways in vascular tree from patients with Type 2 diabetes.

Author

Bernal-Lopez, Rosa M., Llorente-Cortes, Vicenta, Gomez-Carrillo, Victor, Lopez-Carmona, Dolores, Calleja, Fernando, Gomez-Huelgas, Ricardo, Badimon, Lina, and Tinahones, Francisco J.

Subjects
*TYPE 2 diabetes, *BIOMARKERS, *METABOLISM, *POPLITEAL artery, *GENES
Abstract

The aims of this study were to check whether different biomarkers of inflammatory, apoptotic, immunological or lipid pathways had altered their expression in the occluded popliteal artery (OPA) compared with the internal mammary artery (IMA) and femoral vein (FV) and to examine whether glycemic control influenced the expression of these genes. The study included 20 patients with advanced atherosclerosis and type 2 diabetes mellitus, 15 of whom had peripheral arterial occlusive disease (PAOD), from whom samples of OPA and FV were collected. PAOD patients were classified based on their HbA1c as well (HbA1c ≤ 6.5) or poorly (HbA1c>6.5) controlled patients. Controls for arteries without atherosclerosis comprised 5 IMA from patients with ischemic cardiomyopathy (ICM). mRNA, protein expression and histological studies were analyzed in IMA, OPA and FV. After analyzing 46 genes, OPA showed higher expression levels than IMA or FV for genes involved in thrombosis (F3), apoptosis (MMP2, MMP9, TIMP1 and TIM3), lipid metabolism (LRP1 and NDUFA), immune response (TLR2) and monocytes adhesion (CD83). Remarkably, MMP-9 expression was lower in OPA from well-controlled patients. In FV from diabetic patients with HbA1c ≤6.5, gene expression levels of BCL2, CDKN1A, COX2, NDUFA and SREBP2 were higher than in FV from those with HbA1c >6.5. The atherosclerotic process in OPA from diabetic patients was associated with high expression levels of inflammatory, lipid metabolism and apoptotic biomarkers. The degree of glycemic control was associated with gene expression markers of apoptosis, lipid metabolism and antioxidants in FV. However, the effect of glycemic control on pro-atherosclerotic gene expression was very low in arteries with established atherosclerosis. [ABSTRACT FROM AUTHOR]

Published
2012
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