295 results on '"Bernardoni, Fabio"'
Search Results
2. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.
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Schijven, Dick, Postema, Merel C, Fukunaga, Masaki, Matsumoto, Junya, Miura, Kenichiro, de Zwarte, Sonja MC, van Haren, Neeltje EM, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa, Ortiz-García de la Foz, Víctor, Tordesillas-Gutierrez, Diana, Vázquez-Bourgon, Javier, Crespo-Facorro, Benedicto, Alnæs, Dag, Dahl, Andreas, Westlye, Lars T, Agartz, Ingrid, Andreassen, Ole A, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E, Schall, Ulrich, Scott, Rodney J, Carr, Vaughan J, Green, Melissa J, Henskens, Frans A, Loughland, Carmel M, Pantelis, Christos, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo TJ, Nenadić, Igor, Krämer, Bernd, Gruber, Oliver, Satterthwaite, Theodore D, Bustillo, Juan, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D, Ford, Judith M, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan, Fuentes-Claramonte, Paola, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond, Sarró, Salvador, Pomarol-Clotet, Edith, Ciullo, Valentina, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N, Sim, Kang, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André, Borgwardt, Stefan, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, and Antonucci, Linda A
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Brain ,Cerebral Cortex ,Humans ,Magnetic Resonance Imaging ,Case-Control Studies ,Schizophrenia ,Female ,Male ,Functional Laterality ,asymmetry ,brain imaging ,cortical ,subcortical ,Clinical Research ,Mental Health ,Neurosciences ,Brain Disorders ,Mental health - Abstract
Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
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- 2023
3. Virtual Ontogeny of Cortical Growth Preceding Mental Illness
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Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A, Arango, Celso, Arolt, Volker, Auzias, Guillaume, Ayesa-Arriola, Rosa, Banaj, Nerisa, Banaschewski, Tobias, Bandeira, Cibele, Başgöze, Zeynep, Cupertino, Renata Basso, Bau, Claiton HD, Bauer, Jochen, Baumeister, Sarah, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Brem, Silvia, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R, Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J, Cannon, Dara M, Carmona, Susanna, Carr, Vaughan J, Catts, Stanley V, Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G, Conzelmann, Annette, Craven, Alexander R, Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Dannlowski, Udo, Davey, Christopher G, Deruelle, Christine, Díaz-Caneja, Covadonga M, Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T, Fedor, Jennifer, Fitzgerald, Jacqueline, Foran, William, Ford, Judith M, Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Gao, Bingchen, Gao, Si, Goikolea, Jose M, Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J, Green, Melissa, Grevet, Eugenio H, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Haavik, Jan, Hahn, Tim, Harrison, Ben J, Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J, Hilland, Eva, Hoekstra, Pieter J, Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M, Ipser, Jonathan C, Jahanshad, Neda, Jakobi, Babette, Jansen, Andreas, Janssen, Joost, Jonassen, Rune, Kaiser, Anna, Kaleda, Vasiliy, Karantonis, James, King, Joseph A, Kircher, Tilo, Kochunov, Peter, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, and Lawrie, Stephen
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Neurosciences ,Genetics ,Mental Health ,Serious Mental Illness ,Mental Illness ,Women's Health ,Brain Disorders ,Preterm ,Low Birth Weight and Health of the Newborn ,Pregnancy ,Pediatric ,Perinatal Period - Conditions Originating in Perinatal Period ,Behavioral and Social Science ,Prevention ,Schizophrenia ,2.1 Biological and endogenous factors ,2.3 Psychological ,social and economic factors ,Neurological ,Reproductive health and childbirth ,Mental health ,Good Health and Well Being ,Attention Deficit Disorder with Hyperactivity ,Autism Spectrum Disorder ,Bipolar Disorder ,Cerebral Cortex ,Child ,Depressive Disorder ,Major ,Female ,Humans ,Infant ,Newborn ,Magnetic Resonance Imaging ,Premature Birth ,Cortical growth ,Cortical surface area ,Mental illness ,Neurodevelopment ,Neurogenesis ,Psychiatric disorders ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Biological sciences ,Biomedical and clinical sciences - Abstract
BackgroundMorphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life.MethodsInterregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed.ResultsAcross the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth.ConclusionsOur findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.
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- 2022
4. Regional gray matter changes in steatotic liver disease provide a neurobiological link to depression: A cross-sectional UK Biobank cohort study
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Arold, Dominic, Bornstein, Stefan R., Perakakis, Nikolaos, Ehrlich, Stefan, and Bernardoni, Fabio
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- 2024
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5. Dynamic Amygdala Nuclei Alterations in Relation to Weight Status in Anorexia Nervosa Are Mediated by Leptin
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Wronski, Marie-Louis, Bernardoni, Fabio, Bahnsen, Klaas, Seidel, Maria, Arold, Dominic, Doose, Arne, Steinhäuser, Jonas L., Borucki, Katrin, Breithaupt, Lauren, Lawson, Elizabeth A., Holsen, Laura M., Weidner, Kerstin, Roessner, Veit, King, Joseph A., Plessow, Franziska, and Ehrlich, Stefan
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- 2024
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6. No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa
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Weinert, Tomas, Bernardoni, Fabio, King, Joseph, Steding, Julius, Boehm, Ilka, Mannigel, Merle, Ritschel, Franziska, Zepf, Florian, Roessner, Veit, and Ehrlich, Stefan
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- 2023
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7. Extraction of bare Form Factors for $\mathrm B_\mathrm s \to \mathrm K \ell \nu$ Decays in non-perturbative HQET
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Bahr, Felix, Banerjee, Debasish, Bernardoni, Fabio, Koren, Mateusz, Simma, Hubert, and Sommer, Rainer
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High Energy Physics - Lattice - Abstract
We discuss the extraction of the ground state $\langle \mathrm{K} ({\bf p})|V_\mu(0)|\mathrm{B} ({\bf 0})\rangle$ matrix elements from Euclidean lattice correlation functions. The emphasis is on the elimination of excited state contributions. Two typical gauge-field ensembles with lattice spacings $0.075, \; 0.05$ fm and pion masses $330,\;270$ MeV are used from the O($a$)- improved CLS 2-flavour simulations and the final state momentum is $|{\bf p}|=0.5\,{\rm GeV}$. The b-quark is treated in HQET including the $1/m_\mathrm{b}$ corrections. Fits to two-point and three-point correlation functions and suitable ratios including summed ratios are used, yielding consistent results with precision of around 2% which is $not$ limited by the $1/m_\mathrm{b}$ corrections but by the dominating static form factors. Excited state contributions are under reasonable control but are the bottleneck towards precision. We do not yet include a specific investigation of multi-hadron contaminations, a gap in the literature which ought to be filled soon., Comment: 38 pages, 23 figures
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- 2019
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8. Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
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Walton, Esther, Bernardoni, Fabio, Batury, Victoria-Luise, Bahnsen, Klaas, Larivière, Sara, Abbate-Daga, Giovanni, Andres-Perpiña, Susana, Bang, Lasse, Bischoff-Grethe, Amanda, Brooks, Samantha J., Campbell, Iain C., Cascino, Giammarco, Castro-Fornieles, Josefina, Collantoni, Enrico, D’Agata, Federico, Dahmen, Brigitte, Danner, Unna N., Favaro, Angela, Feusner, Jamie D., Frank, Guido K.W., Friederich, Hans-Christoph, Graner, John L., Herpertz-Dahlmann, Beate, Hess, Andreas, Horndasch, Stefanie, Kaplan, Allan S., Kaufmann, Lisa-Katrin, Kaye, Walter H., Khalsa, Sahib S., LaBar, Kevin S., Lavagnino, Luca, Lazaro, Luisa, Manara, Renzo, Miles, Amy E., Milos, Gabriella F., Monteleone, Alessio Maria, Monteleone, Palmiero, Mwangi, Benson, O’Daly, Owen, Pariente, Jose, Roesch, Julie, Schmidt, Ulrike H., Seitz, Jochen, Shott, Megan E., Simon, Joe J., Smeets, Paul A.M., Tamnes, Christian K., Tenconi, Elena, Thomopoulos, Sophia I., van Elburg, Annemarie A., Voineskos, Aristotle N., von Polier, Georg G., Wierenga, Christina E., Zucker, Nancy L., Jahanshad, Neda, King, Joseph A., Thompson, Paul M., Berner, Laura A., and Ehrlich, Stefan
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- 2022
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9. Dynamic Structural Brain Changes in Anorexia Nervosa: A Replication Study, Mega-analysis, and Virtual Histology Approach
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Bahnsen, Klaas, Bernardoni, Fabio, King, Joseph A., Geisler, Daniel, Weidner, Kerstin, Roessner, Veit, Patel, Yash, Paus, Tomáš, and Ehrlich, Stefan
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- 2022
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10. Training a machine learning classifier to identify ADHD based on real-world clinical data from medical records
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Mikolas, Pavol, Vahid, Amirali, Bernardoni, Fabio, Süß, Mathilde, Martini, Julia, Beste, Christian, and Bluschke, Annet
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- 2022
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11. Altered White Matter Connectivity in Young Acutely Underweight Patients With Anorexia Nervosa
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Geisler, Daniel, King, Joseph A., Bahnsen, Klaas, Bernardoni, Fabio, Doose, Arne, Müller, Dirk K., Marxen, Michael, Roessner, Veit, van den Heuvel, Martijn, and Ehrlich, Stefan
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- 2022
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12. Continuum limit of the leading order HQET form factor in $B_s \to K\ell\nu$ decays
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Bahr, Felix, Banerjee, Debasish, Bernardoni, Fabio, Joseph, Anosh, Koren, Mateusz, Simma, Hubert, and Sommer, Rainer
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High Energy Physics - Lattice - Abstract
We discuss the computation of form factors for semi-leptonic decays of $\rm B$-, $\rm B_s$- mesons in lattice QCD. Considering in particular the example of the static $\rm B_s$ form factors we demonstrate that after non-perturbative renormalization the continuum limit can be taken with confidence. The resulting precision is of interest for extractions of $V_{\rm ub}$. The size of the corrections of order $1/m_{\rm b}$ is just estimated at present but it is expected that their inclusion does not pose significant difficulties., Comment: 16 pages, 3 figures; minor corrections and typo fixes, published version
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- 2016
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13. B-meson spectroscopy in HQET at order 1/m
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Bernardoni, Fabio, Blossier, Benoît, Bulava, John, Della Morte, Michele, Fritzsch, Patrick, Garron, Nicolas, Gérardin, Antoine, Heitger, Jochen, von Hippel, Georg, and Simma, Hubert
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We present a study of the B spectrum performed in the framework of Heavy Quark Effective Theory expanded to next-to-leading order in 1/m and non-perturbative in the strong coupling. Our analyses have been performed on Nf=2 lattice gauge field ensembles corresponding to three different lattice spacings and a wide range of pion masses. We obtain the Bs-meson mass and hyperfine splittings of the B- and Bs-mesons that are in good agreement with the experimental values and examine the mass difference m_{Bs}-m_B as a further cross-check of our previous estimate of the b-quark mass. We also report on the mass splitting between the first excited state and the ground state in the B and Bs systems., Comment: 35 pages, 14 tables, 17 figures; Introduction extended and typos corrected. Version accepted for publication in PRD
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- 2015
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14. Form factors for $\mathrm B_\mathrm s \to \mathrm K \ell \nu$ decays in Lattice QCD
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Bahr, Felix, Bernardoni, Fabio, Bulava, John, Joseph, Anosh, Ramos, Alberto, Simma, Hubert, and Sommer, Rainer
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We present the current status of the computation of the form factor $f_+ (q^2)$ for the semi-leptonic decay $\mathrm B_\mathrm s \to \mathrm K \ell \nu$ by the ALPHA collaboration. We use gauge configurations which were generated as part of the Coordinated Lattice Simulations (CLS) effort. They have $N_\mathrm f=2$ non-perturbatively $O(a)$ improved Wilson fermions, and pion masses down to $\approx 250 \,\mathrm {MeV}$ with $m_\pi L \geq 4$. The heavy quark is treated in non-perturbative Heavy Quark Effective Theory (HQET). We discuss how to extract the form factors from the correlation functions and present first results for the form factor at $q^2 = 21.23\,\mathrm{GeV}^2$ extrapolated to the continuum. Next-to-leading order terms in HQET and the chiral extrapolation still need to be included in the analysis., Comment: 6 pages and 3 figures. Proceedings of the 8th International Workshop on the CKM Unitarity Triangle (CKM 2014), Vienna, Austria, September 8-12, 2014
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- 2014
15. The association between body mass index and brain morphology in children: a population-based study
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Steegers, Cathelijne, Blok, Elisabet, Lamballais, Sander, Jaddoe, Vincent, Bernardoni, Fabio, Vernooij, Meike, van der Ende, Jan, Hillegers, Manon, Micali, Nadia, Ehrlich, Stefan, Jansen, Pauline, Dieleman, Gwen, and White, Tonya
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- 2021
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16. Longitudinal changes in brain-derived neurotrophic factor (BDNF) but not cytokines contribute to hippocampal recovery in anorexia nervosa above increases in body mass index.
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Keeler, Johanna Louise, Bahnsen, Klaas, Wronski, Marie-Louis, Bernardoni, Fabio, Tam, Friederike, Arold, Dominic, King, Joseph A., Kolb, Theresa, Poitz, David M., Roessner, Veit, Treasure, Janet, Himmerich, Hubertus, and Ehrlich, Stefan
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CROSS-sectional method ,BODY mass index ,LEANNESS ,RESEARCH funding ,MAGNETIC resonance imaging ,BRAIN-derived neurotrophic factor ,CONVALESCENCE ,ANOREXIA nervosa ,GROWTH factors ,CYTOKINES ,HIPPOCAMPUS (Brain) ,INFLAMMATION ,BIOMARKERS ,TUMOR necrosis factors ,INTERLEUKINS - Abstract
Background: Physical sequelae of anorexia nervosa (AN) include a marked reduction in whole brain volume and subcortical structures such as the hippocampus. Previous research has indicated aberrant levels of inflammatory markers and growth factors in AN, which in other populations have been shown to influence hippocampal integrity. Methods: Here we investigated the influence of concentrations of two pro-inflammatory cytokines (tumor necrosis factor-alpha [TNF- α ] and interleukin-6 [IL-6]) and brain-derived neurotrophic factor (BDNF) on the whole hippocampal volume, as well as the volumes of three regions (the hippocampal body, head, and tail) and 18 subfields bilaterally. Investigations occurred both cross-sectionally between acutely underweight adolescent/young adult females with AN (acAN; n = 82) and people recovered from AN (recAN; n = 20), each independently pairwise age-matched with healthy controls (HC), and longitudinally in acAN after partial renourishment (n = 58). Hippocampal subfield volumes were quantified using FreeSurfer. Concentrations of molecular factors were analyzed in linear models with hippocampal (subfield) volumes as the dependent variable. Results: Cross-sectionally, there was no evidence for an association between IL-6, TNF- α , or BDNF and between-group differences in hippocampal subfield volumes. Longitudinally, increasing concentrations of BDNF were positively associated with longitudinal increases in bilateral global hippocampal volumes after controlling for age, age
2 , estimated total intracranial volume, and increases in body mass index (BMI). Conclusions: These findings suggest that increases in BDNF may contribute to global hippocampal recovery over and above increases in BMI during renourishment. Investigations into treatments targeted toward increasing BDNF in AN may be warranted. [ABSTRACT FROM AUTHOR]- Published
- 2024
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17. Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa
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Bahnsen, Klaas, primary, Wronski, Marie‐Louis, additional, Keeler, Johanna Louise, additional, King, Joseph A., additional, Preusker, Quirina, additional, Kolb, Theresa, additional, Weidner, Kerstin, additional, Roessner, Veit, additional, Bernardoni, Fabio, additional, and Ehrlich, Stefan, additional
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- 2023
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18. Precision lattice QCD computation of the $B^*B\pi$ coupling
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Bernardoni, Fabio, Bulava, John, Donnellan, Michael, and Sommer, Rainer
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High Energy Physics - Lattice - Abstract
The static $B^{*}B\pi$ coupling, $\hat{g}_\chi$, a low energy constant in the leading order heavy meson chiral Lagrangian, is determined using $N_\mathrm{f} = 2$ lattice QCD. We use CLS ensembles with lattice spacings and pion masses down to $a = 0.05\mathrm{fm}$ and $m_{\pi}=270\mathrm{MeV}$, and perform combined continuum and chiral extrapolations of our results which have a much better accuracy than previous numbers in the literature. As a by-product, we determine the coupling between the first radial excitations in the $B$ and $B^{*}$ channels ($\hat{g}_{22}$). Accounting for all uncertainties, which are dominated by the chiral extrapolation, we obtain $\hat{g}_\chi = 0.492(29)$, while $\hat{g}_{22}$ is somewhat smaller. The comparison to a precise quenched computation suggests that there is little influence by the sea quarks and $\hat{g}_\chi$ will not change much when a dynamical strange quark is included., Comment: 14 pages, all included
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- 2014
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19. Abnormal Spontaneous Regional Brain Activity in Young Patients With Anorexia Nervosa
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Seidel, Maria, Borchardt, Viola, Geisler, Daniel, King, Joseph A., Boehm, Ilka, Pauligk, Sophie, Bernardoni, Fabio, Biemann, Ronald, Roessner, Veit, Walter, Martin, and Ehrlich, Stefan
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- 2019
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20. Metabolic state and value-based decision-making in acute and recovered female patients with anorexia nervosa
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Bernardoni, Fabio, Bernhardt, Nadine, Pooseh, Shakoor, King, Joseph A., Geisler, Daniel, Ritschel, Franziska, Boehm, Ilka, Seidel, Maria, Roessner, Veit, Smolka, Michael N., and Ehrlich, Stefan
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Aprotinin ,Women's health ,Medical research ,Anorexia nervosa ,Decision making ,EDTA ,Health ,Psychology and mental health - Abstract
Background: Patients with anorexia nervosa forgo eating despite emaciation and severe health consequences. Such dysfunctional decision-making might be explained by an excessive level of self-control, alterations in homeostatic and hedonic regulation, or an interplay between these processes. We aimed to understand value-based decision-making in anorexia nervosa and its association with the gut hormone ghrelin. Besides its homeostatic function, ghrelin has been implicated in the hedonic regulation of appetite and reward via the modulation of phasic dopamine signalling. Methods: In a cross-sectional design, we studied acutely underweight (n = 94) and recovered (n = 37) patients with anorexia nervosa of the restrictive subtype, as well as healthy control participants (n = 119). We assessed plasma concentrations of desacyl ghrelin and parameters of delay discounting, probability discounting for gains and losses, and loss aversion. Results: Recovered patients displayed higher risk aversion for gains, but we observed no group differences for the remaining decision-making parameters. Desacyl ghrelin was higher in acutely underweight and recovered participants with anorexia nervosa relative to healthy controls. Moreover, we found a significant group x desacyl ghrelin interaction in delay discounting, indicating that in contrast to healthy controls, acutely underweight patients with anorexia nervosa who had high desacyl ghrelin concentrations preferably chose the delayed reward option. Limitations: We probed decision-making using monetary rewards, but patients with anorexia nervosa may react differently to disorder-relevant stimuli. Furthermore, in contrast to acyl ghrelin, the functions of desacyl ghrelin are unclear. Therefore, the interpretation of the results is preliminary. Conclusion: The propensity for risk aversion as found in recovered patients with anorexia nervosa could help them successfully complete therapy, or it could reflect sequelae of the disorder. Conversely, ghrelin findings might be related to a mechanism contributing to disease maintenance; that is, in acutely underweight anorexia nervosa, a hungry state may facilitate the ability to forgo an immediate reward to achieve a (dysfunctional) long-term goal., Introduction Anorexia nervosa is an eating disorder that frequently manifests during adolescence and is characterized by an intense fixation with body weight and self-starvation. Anorexia nervosa often takes a chronic [...]
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- 2020
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21. Intact value-based decision-making during intertemporal choice in women with remitted anorexia nervosa? An fMRI study
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King, Joseph A., Bernardoni, Fabio, Geisler, Daniel, Ritschel, Franziska, Doose, Arne, Pauligk, Sophie, Pasztor, Konrad, Weidner, Kerstin, Roessner, Veit, Smolka, Michael N., and Ehrlich, Stefan
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Shire Pharmaceuticals Group Ltd. ,Novartis AG ,Medical research ,Anorexia nervosa ,Decision making ,Pharmaceutical industry ,Women ,Magnetic resonance imaging ,Eating disorders ,Brain ,Diseases ,Health ,Psychology and mental health - Abstract
Background: Extreme restrictive food choice in anorexia nervosa is thought to reflect excessive self-control and/or abnormal reward sensitivity. Studies using intertemporal choice paradigms have suggested an increased capacity to delay reward in anorexia nervosa, and this may explain an unusual ability to resist immediate temptation and override hunger in the long-term pursuit of thinness. It remains unclear, however, whether altered delay discounting in anorexia nervosa constitutes a state effect of acute illness or a trait marker observable after recovery. Methods: We repeated the analysis from our previous fMRI investigation of intertemporal choice in acutely underweight patients with anorexia nervosa in a sample of weight-recovered women with anorexia nervosa (n = 36) and age-matched healthy controls (n = 36) who participated in the same study protocol. Follow-up analyses explored functional connectivity separately in both the weight-recovered/healthy controls sample and the acute/healthy controls sample. Results: In contrast to our previous findings in acutely underweight patients with anorexia nervosa, we found no differences between weight-recovered patients with anorexia nervosa and healthy controls at either behavioural or neural levels. New analysis of data from the acute/healthy controls sample revealed increased coupling between dorsal anterior cingulate cortex and posterior brain regions as a function of decision difficulty, supporting the hypothesis of altered neural efficiency in the underweight state. Limitations: This was a cross-sectional study, and the results may be task-specific. Conclusion: Although our results underlined previous demonstrations of divergent temporal reward discounting in acutely underweight patients with anorexia nervosa, we found no evidence of alteration in patients with weight-recovered anorexia nervosa. Together, these findings suggest that impaired value-based decision-making may not constitute a defining trait variable or 'scar' of the disorder., Introduction Although many people have difficulty avoiding temptation from unhealthy foods and sticking to a nutritious diet, people with anorexia nervosa seem to resist hunger and restrict caloric intake with [...]
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- 2020
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22. B-physics from non-perturbatively renormalized HQET in two-flavour lattice QCD
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Bernardoni, Fabio, Blossier, Benoit, Bulava, John, Della Morte, Michele, Fritzsch, Patrick, Garron, Nicolas, Gerardin, Antoine, Heitger, Jochen, von Hippel, Georg M., and Simma, Hubert
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We report on the ALPHA Collaboration's lattice B-physics programme based on N_f=2 O(a) improved Wilson fermions and HQET, including all NLO effects in the inverse heavy quark mass, as well as non-perturbative renormalization and matching, to fix the parameters of the effective theory. Our simulations in large physical volume cover 3 lattice spacings a ~ (0.08-0.05) fm and pion masses down to 190 MeV to control continuum and chiral extrapolations. We present the status of results for the b-quark mass and the B_(s)-meson decay constants, f_B and f_{B_s}., Comment: Presented at the 16th International Conference in Quantum Chromodynamics (QCD 2012), 2-7 July 2012, Montpellier, France; 7 pages including figures, latex2e, uses elsarticle.cls
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- 2012
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23. B $\to$ $\pi$ form factor with 2 flavours of $O(a)$ improved Wilson quarks
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Bahr, Felix, Bernardoni, Fabio, Bulava, John, Ramos, Alberto, Simma, Hubert, and Sommer, Rainer
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
The determinations of $|V_{\rm ub}|$ from the exclusive branching ratios of $B\to \tau \nu$ and $B \to \pi l \nu$ tend to show a tension at the level of $3\sigma$ \cite{Beringer:1900zz}. On the theoretical side they depend on the lattice computation of the hadronic matrix elements $f_{\rm B}$ and the $B\to \pi$ form factor $f_+(q^2)$. To understand the tension, improved precision and a careful analysis of the systematics involved are necessary. Working towards this goal, we present preliminary lattice results of the ALPHA collaboration for the $B\to \pi$ form factor $f_+(q^2)$ with $N_{\rm f}=2$ flavours of $O(a)$-improved Wilson fermions. Our computation uses HQET in the static limit, pion masses ranging down to $\sim250$ MeV, large volumes with $m_\pi L >4$, three lattice spacings, and non-perturbative renormalization. We describe the techniques adopted to reduce the statistical noise (stochastic all-to-all with full time dilution) and the contamination from excited states (smearing for the B and the pion). We estimate the size of the chiral and continuum extrapolations. We discuss the impact our result could have to clarify the above mentioned discrepancy in the determination of $|V_{\rm ub}|$., Comment: 7 pages, 6 figures. proceedings for the 2012 lattice conference, cairns, australia
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- 2012
24. Determination of the Wilson ChPT low energy constant c_2
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Bernardoni, Fabio, Bulava, John, and Sommer, Rainer
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High Energy Physics - Lattice - Abstract
Following a suggestion by Aoki and B\"ar, c2 can be extracted by analyzing volume effects in 2-pion states. To this end we consider renormalized ratios of four point to two point correlation functions. We present the results from various CLS lattices, with pion masses ranging from 280 to 450 MeV and lattice spacings of 0.07 fm and 0.08 fm. This low energy constant is useful to understand discretization effects in chiral extrapolations with Wilson fermions, especially for quantities which vanish in the chiral limit, like the pion mass. Since our procedure is computationally cheap and straightforward, it is recommended as a routine study for any Wilson-type simulation, as a check of discretization effects., Comment: 6 pages, 5 figures, talk presented at the 2011 lattice conference, lake tahoe, california
- Published
- 2011
25. Light quark correlators in a mixed-action setup
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Bernardoni, Fabio, Garron, Nicolas, Hernandez, Pilar, Necco, Silvia, and Pena, Carlos
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High Energy Physics - Lattice - Abstract
We report our progress in simulating Neuberger valence fermions on N_f=2 Wilson O(a)-improved sea quarks. We compute correlators with valence quark masses both in the p- and in the epsilon-regime, and we match the results with the predictions of the Chiral Effective Theory in the mixed regime. This allows us to extract the Low Energy Couplings (LECs) of the N_f=2 theory and to test the validity of the approach., Comment: 7 pages, 3 figures
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- 2011
26. Exploring the chiral regime of $N_f=2$ QCD with mixed actions
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Bernardoni, Fabio, Garron, Nicolas, Hernandez, Pilar, Necco, Silvia, and Pena, Carlos
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High Energy Physics - Lattice - Abstract
We report on our simulations with Neuberger valence fermions on CLS $N_f=2$ configurations with non-perturbatively $O(a)$-improved Wilson sea quarks. We consider the matching of QCD to ChPT in the so called mixed-regime in which the sea quarks are in the $p$-regime while the valence quarks are in the $\epsilon$-regime. From this matching, we can get information on $\Sigma$, $L_6$ and the combination $L_8+2L_6+2L_7$., Comment: 7 pages, 4 figures, Lattice 2010 proceedings
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- 2010
27. Probing the chiral regime of Nf=2 QCD with mixed actions
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Bernardoni, Fabio, Garron, Nicolas, Hernandez, Pilar, Necco, Silvia, and Pena, Carlos
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High Energy Physics - Lattice - Abstract
We report on our first experiences with a mixed action setup with overlap valence quarks and non-perturbatively O(a) improved Wilson sea quarks. For the latter we employ CLS Nf=2 configurations with light sea quark masses at small lattice spacings. Exact chiral symmetry allows to consider very light valence quarks and explore the matching to (partially quenched) Chiral Perturbation Theory (ChPT) in a mixed epsilon/p-regime. We compute the topological susceptibility and the low-lying spectrum of the massless Neuberger-Dirac operator for three values of the sea quark mass, and compare the sea quark mass dependence to NLO ChPT in the mixed regime. This provides two different determinations of the chiral condensate, as well as information about some NLO low-energy couplings. Our results allow to test the consistency of the mixed-regime approach to ChPT, as well as of the mixed action framework., Comment: 33 pages, 15 figures. v2: extended discussion of matching to Random Matrix Theory, minor changes in analysis; published version
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- 2010
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28. Finite-size scaling of heavy-light mesons
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Bernardoni, Fabio, Hernandez, Pilar, and Necco, Silvia
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High Energy Physics - Lattice - Abstract
We study the finite-size scaling of heavy-light mesons in the static limit. The most relevant effects are due to the pseudo-Goldstone boson cloud. In the HMChPT framework we compute two-point functions of left current densitities as well as pseudoscalar densitites for the cases in which some or all of them lay in the epsilon-regime. As expected, finite volume dependence turns out to be significant in this regime and can be predicted in the effective theory in terms of the infinite-volume low-energy couplings. These results might be relevant for extraction of heavy-light meson properties from lattice simulations., Comment: 7 pages, 2 figures, Contributed to 27th International Symposium on Lattice Field Theory, Beijing, China, 26 - 31 Jul 2009
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- 2009
29. Heavy-light mesons in the epsilon-regime
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Bernardoni, Fabio, Hernandez, Pilar, and Necco, Silvia
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High Energy Physics - Lattice - Abstract
We study the finite-size scaling of heavy-light mesons in the static limit. We compute two-point functions of chiral current densities as well as pseudoscalar densities in the epsilon-regime of heavy meson Chiral Perturbation Theory (HMChPT). As expected, finite volume dependence turns out to be significant in this regime and can be predicted in the effective theory in terms of the infinite-volume low-energy couplings. These results might be relevant for extraction of heavy-meson properties from lattice simulations., Comment: 32 pages, 4 figures
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- 2009
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30. Nutritional Status Affects Cortical Folding: Lessons Learned From Anorexia Nervosa
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Bernardoni, Fabio, King, Joseph A., Geisler, Daniel, Birkenstock, Julian, Tam, Friederike I., Weidner, Kerstin, Roessner, Veit, White, Tonya, and Ehrlich, Stefan
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- 2018
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31. Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa.
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Bahnsen, Klaas, Wronski, Marie‐Louis, Keeler, Johanna Louise, King, Joseph A., Preusker, Quirina, Kolb, Theresa, Weidner, Kerstin, Roessner, Veit, Bernardoni, Fabio, and Ehrlich, Stefan
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ANOREXIA nervosa ,BODY image ,BODY image disturbance ,HIPPOCAMPUS (Brain) ,WEIGHT gain ,MAGNETIC resonance imaging - Abstract
Background: Anorexia nervosa (AN) is a mental disorder characterized by dietary restriction, fear of gaining weight, and distorted body image. Recent studies indicate that the hippocampus, crucial for learning and memory, may be affected in AN, yet subfield‐specific effects remain unclear. We investigated hippocampal subfield alterations in acute AN, changes following weight restoration, and their associations with leptin levels. Methods: T1‐weighted magnetic resonance imaging scans were processed using FreeSurfer. We compared 22 left and right hemispheric hippocampal subfield volumes cross‐sectionally and longitudinally in females with acute AN (n = 165 at baseline, n = 110 after partial weight restoration), healthy female controls (HCs; n = 271), and females after long‐term recovery from AN (n = 79) using linear models. Results: We found that most hippocampal subfield volumes were significantly reduced in patients with AN compared with HCs (~−3.9%). Certain areas such as the subiculum exhibited no significant reduction in the acute state of AN, while other areas, such as the hippocampal tail, showed strong decreases (~−9%). Following short‐term weight recovery, most subfields increased in volume. Comparisons between participants after long‐term weight‐recovery and HC yielded no differences. The hippocampal tail volume was positively associated with leptin levels in AN independent of body mass index. Conclusions: Our study provides evidence of differential volumetric differences in hippocampal subfields between individuals with AN and HC and almost complete normalization after weight rehabilitation. These alterations are spatially inhomogeneous and more pronounced compared with other major mental disorders (e.g. major depressive disorder and schizophrenia). We provide novel insights linking hypoleptinemia to hippocampal subfield alterations hinting towards clinical relevance of leptin normalization in AN recovery. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Dynamic Amygdala Nuclei Alterations in Relation to Weight Status in Anorexia Nervosa Are Mediated by Leptin
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Wronski, Marie-Louis, primary, Bernardoni, Fabio, additional, Bahnsen, Klaas, additional, Seidel, Maria, additional, Arold, Dominic, additional, Doose, Arne, additional, Steinhäuser, Jonas L., additional, Borucki, Katrin, additional, Breithaupt, Lauren, additional, Lawson, Elizabeth A., additional, Holsen, Laura M., additional, Weidner, Kerstin, additional, Roessner, Veit, additional, King, Joseph A., additional, Plessow, Franziska, additional, and Ehrlich, Stefan, additional
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- 2023
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33. Explicating the role of amygdala substructure alterations in the link between hypoleptinemia and rumination in anorexia nervosa
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Wronski, Marie‐Louis, primary, Hohnemann, Charlotte, additional, Bernardoni, Fabio, additional, Bahnsen, Klaas, additional, Doose, Arne, additional, Arold, Dominic, additional, Borucki, Katrin, additional, Holsen, Laura M., additional, Lawson, Elizabeth A., additional, Plessow, Franziska, additional, Weidner, Kerstin, additional, Roessner, Veit, additional, Diestel, Stefan, additional, King, Joseph A., additional, Seidel, Maria, additional, and Ehrlich, Stefan, additional
- Published
- 2023
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34. Predicting long-term outcome in anorexia nervosa: a machine learning analysis of brain structure at different stages of weight recovery
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Arold, Dominic, primary, Bernardoni, Fabio, additional, Geisler, Daniel, additional, Doose, Arne, additional, Uen, Volkan, additional, Boehm, Ilka, additional, Roessner, Veit, additional, King, Joseph A., additional, and Ehrlich, Stefan, additional
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- 2023
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35. Mapping the geometry of the E6 group
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Bernardoni, Fabio, Cacciatori, Sergio L., Cerchiai, Bianca L., and Scotti, Antonio
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Mathematical Physics ,High Energy Physics - Theory - Abstract
In this paper we present a construction for the compact form of the exceptional Lie group E6 by exponentiating the corresponding Lie algebra e6, which we realize as the the sum of f4, the derivations of the exceptional Jordan algebra J3 of dimension 3 with octonionic entries, and the right multiplication by the elements of J3 with vanishing trace. Our parametrization is a generalization of the Euler angles for SU(2) and it is based on the fibration of E6 via a F4 subgroup as the fiber. It makes use of a similar construction we have performed in a previous article for F4. An interesting first application of these results lies in the fact that we are able to determine an explicit expression for the Haar invariant measure on the E6 group manifold., Comment: 30 pages
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- 2007
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36. Mapping the geometry of the F4 group
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Bernardoni, Fabio, Cacciatori, Sergio L., Cerchiai, Bianca L., and Scotti, Antonio
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Mathematical Physics ,High Energy Physics - Theory ,22E46 ,22E70 - Abstract
In this paper we present a construction of the compact form of the exceptional Lie group F4 by exponentiating the corresponding Lie algebra f4. We realize F4 as the automorphisms group of the exceptional Jordan algebra, whose elements are 3 x 3 hermitian matrices with octonionic entries. We use a parametrization which generalizes the Euler angles for SU(2) and is based on the fibration of F4 via a Spin(9) subgroup as a fiber. This technique allows us to determine an explicit expression for the Haar invariant measure on the F4 group manifold. Apart from shedding light on the structure of F4 and its coset manifold OP2=F4/Spin(9), the octonionic projective plane, these results are a prerequisite for the study of E6, of which F4 is a (maximal) subgroup., Comment: 50 pages; some typos corrected
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- 2007
37. Evaluation of spontaneous regional brain activity in weight-recovered anorexia nervosa
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Seidel, Maria, Geisler, Daniel, Borchardt, Viola, King, Joseph A., Bernardoni, Fabio, Jaite, Charlotte, Roessner, Veit, Calhoun, Vince, Walter, Martin, and Ehrlich, Stefan
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- 2020
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38. Mapping the geometry of the F4 group
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Bernardoni, Fabio
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Mathematics and Computing ,Physics of elementary particles and fields ,exceptional Lie groups ,Haar measure ,coset spaces ,geometry - Abstract
In this paper, we present a construction of the compact form of the exceptional Lie group F4 by exponentiating the corresponding Lie algebra f4. We realize F4 as the automorphisms group of the exceptional Jordan algebra, whose elements are 3 x 3 Hermitian matrices with octonionic entries. We use a parametrization which generalizes the Euler angles for SU(2) and is based on the fibration of F4 via a Spin(9) subgroup as a fiber. This technique allows us to determine an explicit expression for the Haar invariant measure on the F4 group manifold. Apart from shedding light on the structure of F4 and its coset manifold OP2 = F4/Spin(9), the octonionic projective plane, these results are a prerequisite for the study of E6, of which F4 is a (maximal) subgroup.
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- 2009
39. Mapping the geometry of the E6 group
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Bernardoni, Fabio
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Physics of elementary particles and fields - Published
- 2008
40. Serum neurofilament light concentrations are associated with cortical thinning in anorexia nervosa.
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Hellerhoff, Inger, Bernardoni, Fabio, Bahnsen, Klaas, King, Joseph A., Doose, Arne, Pauligk, Sophie, Tam, Friederike I., Mannigel, Merle, Gramatke, Katrin, Roessner, Veit, Akgün, Katja, Ziemssen, Tjalf, and Ehrlich, Stefan
- Subjects
- *
BRAIN anatomy , *BIOMARKERS , *NERVE tissue proteins , *NEURONS , *TAU proteins , *CEREBRAL cortical thinning , *CYTOSKELETAL proteins , *MAGNETIC resonance imaging , *RISK assessment , *WEIGHT gain , *DESCRIPTIVE statistics , *RESEARCH funding , *ANOREXIA nervosa , *BODY mass index , *DISEASE risk factors - Abstract
Background: Anorexia nervosa (AN) is characterized by severe emaciation and drastic reductions of brain mass, but the underlying mechanisms remain unclear. The present study investigated the putative association between the serum-based protein markers of brain damage neurofilament light (NF-L), tau protein, and glial fibrillary acidic protein (GFAP) and cortical thinning in acute AN. Methods: Blood samples and magnetic resonance imaging scans were obtained from 52 predominantly adolescent, female patients with AN before and after partial weight restoration (increase in body mass index >14%). The effect of marker levels before weight gain and change in marker levels on cortical thickness (CT) was modeled at each vertex of the cortical surface using linear mixed-effect models. To test whether the observed effects were specific to AN, follow-up analyses exploring a potential general association of marker levels with CT were conducted in a female healthy control (HC) sample (n = 147). Results: In AN, higher baseline levels of NF-L, an established marker of axonal damage, were associated with lower CT in several regions, with the most prominent clusters located in bilateral temporal lobes. Tau protein and GFAP were not associated with CT. In HC, no associations between damage marker levels and CT were detected. Conclusions: A speculative interpretation would be that cortical thinning in acute AN might be at least partially a result of axonal damage processes. Further studies should thus test the potential of serum NF-L to become a reliable, low-cost and minimally invasive marker of structural brain alterations in AN. [ABSTRACT FROM AUTHOR]
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- 2023
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41. Altered Neural Efficiency of Decision Making During Temporal Reward Discounting in Anorexia Nervosa
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King, Joseph A., Geisler, Daniel, Bernardoni, Fabio, Ritschel, Franziska, Böhm, Ilka, Seidel, Maria, Mennigen, Eva, Ripke, Stephan, Smolka, Michael N., Roessner, Veit, and Ehrlich, Stefan
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- 2016
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42. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
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Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, Francks, Clyde; https://orcid.org/0000-0002-9098-890X, Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, and Francks, Clyde; https://orcid.org/0000-0002-9098-890X
- Abstract
Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, using MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets in the ENIGMA consortium, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macro-structural asymmetry may reflect differences at the molecular, cytoarchitectonic or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.
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- 2023
43. Mouse‐cursor trajectories reveal reduced contextual influence on decision conflict during delay discounting in anorexia nervosa.
- Author
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Bernardoni, Fabio, King, Joseph A., Hellerhoff, Inger, Schoemann, Martin, Seidel, Maria, Geisler, Daniel, Boehm, Ilka, Pauligk, Sophie, Doose, Arne, Steding, Julius, Gramatke, Katrin, Roessner, Veit, Scherbaum, Stefan, and Ehrlich, Stefan
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DELAY discounting (Psychology) , *SELF-control , *CONFLICT (Psychology) , *DECISION making , *RESEARCH funding , *DESCRIPTIVE statistics , *ANOREXIA nervosa , *REACTION time , *GOAL (Psychology) , *PSYCHOSOCIAL factors - Abstract
Objective: The capacity of individuals with anorexia nervosa (AN) to forgo immediate food rewards in their long‐term pursuit of thinness is thought to reflect elevated self‐control and/or abnormal reward sensitivity. Prior research attempted to capture an increased tendency to delay gratification in AN using delay‐discounting tasks that assess how rapidly the subjective value of rewards decreases as a function of time until receipt. However, significant effects were mostly subtle or absent. Here, we tested whether the process leading to such decisions might be altered in AN. Method: We recorded mouse‐cursor movement trajectories leading to the final choice in a computerized delay‐discounting task (238 trials) in 55 acutely underweight females with AN and pairwise age‐matched female healthy controls (HC). We tested for group differences in deviations from a direct choice path, a measure of conflict strength in decision making, and whether group moderated the effect of several predictors of conflict strength (e.g., choice difficulty, consistency). We also explored reaction times and changes in trajectory directions (X‐flips). Results: No group differences in delay‐discounting parameters or movement trajectories were detected. However, the effect of the aforementioned predictors on deviations (and to a lesser extent reaction times) was reduced in AN. Discussion: These findings suggest that while delay discounting and conflict strength in decision making are generally unaltered in AN, conflict strength was more stable across different decisions in the disorder. This might enable individuals with AN to pursue (maladaptive) long‐term body‐weight goals, because particularly conflicting choices may not be experienced as such. Public Significance: The deviations from a direct path of mouse‐cursor movements during a computerized delay‐discounting task varied less in people with anorexia nervosa. Assuming such deviations measure decision conflict, we speculate that this increased stability might help people with anorexia nervosa achieve their long‐term weight goals, as for them the struggle with the decision to eat high‐calorie meals when hungry will be milder, so they would be more likely to skip them. [ABSTRACT FROM AUTHOR]
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- 2023
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44. Differential alterations of amygdala nuclei volumes in acutely ill patients with anorexia nervosa and their associations with leptin levels.
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Wronski, Marie-Louis, Geisler, Daniel, Bernardoni, Fabio, Seidel, Maria, Bahnsen, Klaas, Doose, Arne, Steinhäuser, Jonas L., Gronow, Franziska, Böldt, Luisa V., Plessow, Franziska, Lawson, Elizabeth A., King, Joseph A., Roessner, Veit, and Ehrlich, Stefan
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IN vivo studies ,LEPTIN ,CROSS-sectional method ,MAGNETIC resonance imaging ,REGRESSION analysis ,DESCRIPTIVE statistics ,RESEARCH funding ,ANOREXIA nervosa ,AMYGDALOID body - Abstract
Background: The amygdala is a subcortical limbic structure consisting of histologically and functionally distinct subregions. New automated structural magnetic resonance imaging (MRI) segmentation tools facilitate the in vivo study of individual amygdala nuclei in clinical populations such as patients with anorexia nervosa (AN) who show symptoms indicative of limbic dysregulation. This study is the first to investigate amygdala nuclei volumes in AN, their relationships with leptin, a key indicator of AN-related neuroendocrine alterations, and further clinical measures. Methods: T1-weighted MRI scans were subsegmented and multi-stage quality controlled using FreeSurfer. Left/right hemispheric amygdala nuclei volumes were cross-sectionally compared between females with AN (n = 168, 12–29 years) and age-matched healthy females (n = 168) applying general linear models. Associations with plasma leptin, body mass index (BMI), illness duration, and psychiatric symptoms were analyzed via robust linear regression. Results: Globally, most amygdala nuclei volumes in both hemispheres were reduced in AN v. healthy control participants. Importantly, four specific nuclei (accessory basal, cortical, medial nuclei, corticoamygdaloid transition in the rostral-medial amygdala) showed greater volumetric reduction even relative to reductions of whole amygdala and total subcortical gray matter volumes, whereas basal, lateral, and paralaminar nuclei were less reduced. All rostral-medially clustered nuclei were positively associated with leptin in AN independent of BMI. Amygdala nuclei volumes were not associated with illness duration or psychiatric symptom severity in AN. Conclusions: In AN, amygdala nuclei are altered to different degrees. Severe volume loss in rostral-medially clustered nuclei, collectively involved in olfactory/food-related reward processing, may represent a structural correlate of AN-related symptoms. Hypoleptinemia might be linked to rostral-medial amygdala alterations. [ABSTRACT FROM AUTHOR]
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- 2023
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45. Differential alterations of amygdala nuclei volumes in acutely ill patients with anorexia nervosa and their associations with leptin levels
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Wronski, Marie-Louis, primary, Geisler, Daniel, additional, Bernardoni, Fabio, additional, Seidel, Maria, additional, Bahnsen, Klaas, additional, Doose, Arne, additional, Steinhäuser, Jonas L., additional, Gronow, Franziska, additional, Böldt, Luisa V., additional, Plessow, Franziska, additional, Lawson, Elizabeth A., additional, King, Joseph A., additional, Roessner, Veit, additional, and Ehrlich, Stefan, additional
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- 2022
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46. Predicting long-term outcome in anorexia nervosa: a machine learning analysis of brain structure at different stages of weight recovery
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Bernardoni, Fabio and Arold, Dominic
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- 2023
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47. Partially restored resting-state functional connectivity in women recovered from anorexia nervosa
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Boehm, Ilka, Geisler, Daniel, Tam, Friederike, King, Joseph A., Ritschel, Franziska, Seidel, Maria, Bernardoni, Fabio, Murr, Julia, Goschke, Thomas, Calhoun, Vince D., Roessner, Veit, and Ehrlich, Stefan
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Neural circuitry -- Health aspects ,Anorexia nervosa -- Development and progression -- Physiological aspects ,Cingulate cortex -- Health aspects ,Health ,Psychology and mental health - Abstract
Background: We have previously shown increased resting-state functional connectivity (rsFC) in the frontoparietal network (FPN) and the default mode network (DMN) in patients with acute anorexia nervosa. Based on these findings we investigated within-network rsFC in patients recovered from anorexia nervosa to examine whether these abnormalities are a state or trait marker of the disease. To extend the understanding of functional connectivity in patients with anorexia nervosa, we also estimated rsFC between large-scale networks. Methods: Girls and women recovered from anorexia nervosa and pair-wise, age- and sex-matched healthy controls underwent a resting-state fMRI scan. Using independent component analyses (ICA), we isolated the FPN, DMN and salience network. We used standard comparisons as well as a hypothesis-based approach to test the findings of our previous rsFC study in this recovered cohort. Temporal correlations between network time-course pairs were computed to investigate functional network connectivity (FNC). Results: Thirty-one patients recovered from anorexia nervosa and 31 controls participated in our study. Standard group comparisons revealed reduced rsFC between the dorsolateral prefrontal cortex (dlPFC) and the FPN in the recovered group. Using a hypothesis-based approach we extended the previous finding of increased rsFC between the angular gyrus and the FPN in patients recovered from anorexia nervosa. No group differences in FNC were revealed. Limitations: The study design did not allow us to conclude that the difference found in rsFC constitutes a scar effect of the disease. Conclusion: This study suggests that some abnormal rsFC patterns found in patients recovered from anorexia nervosa normalize after long-term weight restoration, while distorted rsFC in the FPN, a network that has been associated with cognitive control, may constitute a trait marker of the disorder., Introduction Anorexia nervosa is a severe psychiatric disorder hallmarked by extreme weight loss (or failure to gain weight during growth) due to relentless control of food intake and has been [...]
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- 2016
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48. A naturalistic examination of negative affect and disorder-related rumination in anorexia nervosa
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Seidel, Maria, Petermann, Juliane, Diestel, Stefan, Ritschel, Franziska, Boehm, Ilka, King, Joseph A., Geisler, Daniel, Bernardoni, Fabio, Roessner, Veit, Goschke, Thomas, and Ehrlich, Stefan
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- 2016
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49. The real-life costs of emotion regulation in anorexia nervosa: a combined ecological momentary assessment and fMRI study
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Seidel, Maria, King, Joseph A., Ritschel, Franziska, Boehm, Ilka, Geisler, Daniel, Bernardoni, Fabio, Holzapfel, Larissa, Diestel, Stefan, Diers, Kersten, Strobel, Alexander, Goschke, Thomas, Walter, Henrik, Roessner, Veit, and Ehrlich, Stefan
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- 2018
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50. No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa
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Weinert, Tomas, primary, Bernardoni, Fabio, additional, King, Joseph, additional, Steding, Julius, additional, Boehm, Ilka, additional, Mannigel, Merle, additional, Ritschel, Franziska, additional, Zepf, Florian, additional, Roessner, Veit, additional, and Ehrlich, Stefan, additional
- Published
- 2022
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