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1,116 results on '"Berneman, Zwi"'

3. 10-day decitabine versus 3 + 7 chemotherapy followed by allografting in older patients with acute myeloid leukaemia: an open-label, randomised, controlled, phase 3 trial

Author

Finke, Jürgen, Schaap, Nicolaas Petrus Michael, Zucenka, Andrius, Metzelder, Stephan, Jost, Edgar, Perić, Zinaida, Forghieri, Fabio, Allione, Bernadino, Martelli, Maurizio, Iori, Anna Paola, Wittnebel, Sebastian, Mengarelli, Andrea, Imovilli, Annalisa, Olivieri, Attilio, De Prijck, Bernard José Marie, van der Poel, Marjolein W.M., Junghanß, Christian, Salih, Helmut Rainer, Tafuri, Agostino, Guimarães, José Eduardo, Musso, Maurizio, De Fabritiis, Paolo, Chevallier, Patrice, Selleslag, Dominik Luc, Cascavilla, Nicola, Berneman, Zwi, Jaspers, Aurélie, Zuffa, Eliana, Vanstraelen, Gaëtan, Visani, Giuseppe, Cuijpers, Maria Louisa Henriëtte, De Becker, Ann, Mianulli, Anna Maria, Hackanson, Björn, Mihaylov, Georgi Georgiev, Martinelli, Giovanni, Paolini, Stefania, Zinzani, Pier Luigi, Henkes, Martin, Al-Ali, Haifa Kathrin, La Rosée, Paul, Chierichini, Anna, Cudillo, Laura, Specchia, Giorgina, Šimec, Njetočka Gredelj, Capalbo, Silvana Franca, Spinosa, Giuseppina, Molica, Stefano, de Jonge-Peeters, Susan Dorothé, Lübbert, Michael, Wijermans, Pierre W, Kicinski, Michal, Chantepie, Sylvain, Van der Velden, Walter J F M, Noppeney, Richard, Griškevičius, Laimonas, Neubauer, Andreas, Crysandt, Martina, Vrhovac, Radovan, Luppi, Mario, Fuhrmann, Stephan, Audisio, Ernesta, Candoni, Anna, Legrand, Olivier, Foà, Robin, Gaidano, Gianluca, van Lammeren-Venema, Danielle, Posthuma, Eduardus F M, Hoogendoorn, Mels, Giraut, Anne, Stevens-Kroef, Marian, Jansen, Joop H, de Graaf, Aniek O, Efficace, Fabio, Ammatuna, Emanuele, Vilque, Jean-Pierre, Wäsch, Ralph, Becker, Heiko, Blijlevens, Nicole, Dührsen, Ulrich, Baron, Frédéric, Suciu, Stefan, Amadori, Sergio, Venditti, Adriano, and Huls, Gerwin

Published
2023
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4. Effectiveness and Safety of Ibrutinib for Chronic Lymphocytic Leukemia in Routine Clinical Practice: 3-Year Follow-up of the Belgian Ibrutinib Real-World Data (BiRD) Study

Author

Janssens, Ann, Berneman, Zwi N., Offner, Fritz, Snauwaert, Sylvia, Mineur, Philippe, Vanstraelen, Gaetan, Meers, Stef, Spoormans, Isabelle, Bron, Dominique, Vande Broek, Isabelle, Van Bogaert, Charlotte, De Beleyr, Birgit, Smet, Ann, Nielsen, Lasse, Wapenaar, Robert, and André, Marc

Published
2022
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6. WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome.

Author

Berneman, Zwi N., De Laere, Maxime, Germonpré, Paul, Huizing, Manon T., Willemen, Yannick, Lion, Eva, De Reu, Hans, Van den Bossche, Jolien, Van den Brande, Jan, Specenier, Pol, Altintas, Sevilay, van Dam, Peter A., Cools, Nathalie, Nijs, Griet, Stein, Barbara, Caluwaerts, Kim, Snoeckx, Annemiek, Op de Beeck, Bart, Saevels, Kirsten, and Rutsaert, Lynn

Subjects
*NEPHROBLASTOMA, *METASTATIC breast cancer, *CELLULAR therapy, *MEDICAL sciences, *GLIOBLASTOMA multiforme
Abstract

Cell therapies, including tumor antigen-loaded dendritic cells used as therapeutic cancer vaccines, offer treatment options for patients with malignancies. We evaluated the feasibility, safety, immunogenicity, and clinical activity of adjuvant vaccination with Wilms' tumor protein (WT1) mRNA-electroporated autologous dendritic cells (WT1-mRNA/DC) in a single-arm phase I/II clinical study of patients with advanced solid tumors receiving standard therapy. Disease status and immune reactivity were evaluated after 8 weeks and 6 months. WT1-mRNA/DC vaccination was feasible in all patients, except one. Vaccination was well tolerated without evidence of systemic toxicity. The disease control rate and overall response rate among a total of 39 evaluable patients were 74.4% and 12.8%, respectively. Median overall survival (OS) was 43.7 months among 13 patients with glioblastoma multiforme, 41.9 months among 12 patients with metastatic breast cancer, and 48.8 months among 10 patients with malignant pleural mesothelioma, comparing favourably with historical controls reported in the literature. OS was longer in patients with stable disease at 8 weeks and disease control at 6 months versus patients without disease control at either time point. Disease control and higher OS were associated with antigen-specific type 1 CD4+ and/or CD8+ T-lymphocyte responses, mainly induced by WT1-mRNA/DC vaccination. Antigen-nonspecific type 2 CD8+ T-cell responses were common before WT1-mRNA/DC vaccination but did not show any association with clinical outcome. Collectively, these data indicate that WT1-mRNA/DC vaccination is feasible, safe, and immunogenic and shows clinical activity in patients with advanced solid tumors, suggesting that it has the potential to help improve their survival. [ABSTRACT FROM AUTHOR]

Published
2025
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7. Luminescent Human iPSC-Derived Neurospheroids Enable Modeling of Neurotoxicity After Oxygen–glucose Deprivation

Author

Van Breedam, Elise, Nijak, Aleksandra, Buyle-Huybrecht, Tamariche, Di Stefano, Julia, Boeren, Marlies, Govaerts, Jonas, Quarta, Alessandra, Swartenbroekx, Tine, Jacobs, Eva Z., Menten, Björn, Gijsbers, Rik, Delputte, Peter, Alaerts, Maaike, Hassannia, Behrouz, Loeys, Bart, Berneman, Zwi, Timmermans, Jean-Pierre, Jorens, Philippe G., Vanden Berghe, Tom, Fransen, Erik, Wouters, An, De Vos, Winnok H., and Ponsaerts, Peter

Published
2022
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10. Immunoglobin G/total antibody testing for SARS-CoV-2: A prospective cohort study of ambulatory patients and health care workers in two Belgian oncology units comparing three commercial tests

Author

van Dam, Peter, Huizing, Manon, Roelant, Ella, Hotterbeekx, An, De Winter, Fien H.R., Kumar-Singh, Samir, Moons, Pieter, Amajoud, Zainab, Vulsteke, Christof, Croes, Lieselot, Janssens, Annelies, Berneman, Zwi, Prenen, Hans, Meuris, Leander, Vanden Berghe, Wim, Smits, Evelien, and Peeters, Marc

Published
2021
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11. Sequential administration of low dose 5-azacytidine (AZA) and donor lymphocyte infusion (DLI) for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) in relapse after allogeneic stem cell transplantation (SCT): a prospective study from the Belgian Hematology Society (BHS)

Author

Poiré, Xavier, Graux, Carlos, Ory, Aurélie, Herman, Julie, Baron, Frédéric, Schoemans, Hélène, Lewalle, Philippe, De Becker, Ann, Deeren, Dries, Berneman, Zwi, Kerre, Tessa, Zachée, Pierre, Selleslag, Dominik, and Beguin, Yves

Published
2022
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12. SARS-CoV-2 and cancer: Are they really partners in crime?

Author

van Dam, Peter A., Huizing, Manon, Mestach, Gino, Dierckxsens, Stazie, Tjalma, Wiebren, Trinh, Xuan Bich, Papadimitriou, Kostantinos, Altintas, Sevilay, Vermorken, Jan, Vulsteke, Christof, Janssens, Annelies, Berneman, Zwi, Prenen, Hans, Meuris, Leander, Vanden Berghe, Wim, Smits, Evelien, and Peeters, Marc

Published
2020
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15. Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of FLT3

Author

Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, null, null, Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, and null, null

Abstract

PURPOSEAllogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with AML harboring an internal tandem duplication mutation of FLT3 (FLT3-ITD) AML. These patients are routinely treated with a FLT3 inhibitor after HCT, but there is limited evidence to support this. Accordingly, we conducted a randomized trial of post-HCT maintenance with the FLT3 inhibitor gilteritinib (ClinicalTrials.gov identifier: NCT02997202) to determine if all such patients benefit or if detection of measurable residual disease (MRD) could identify those who might benefit.METHODSAdults with FLT3-ITD AML in first remission underwent HCT and were randomly assigned to placebo or 120 mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival (RFS). Secondary end points included overall survival (OS) and the effect of MRD pre- and post-HCT on RFS and OS.RESULTSThree hundred fifty-six participants were randomly assigned post-HCT to receive gilteritinib or placebo. Although RFS was higher in the gilteritinib arm, the difference was not statistically significant (hazard ratio [HR], 0.679 [95% CI, 0.459 to 1.005]; two-sided P =.0518). However, 50.5% of participants had MRD detectable pre- or post-HCT, and, in a prespecified subgroup analysis, gilteritinib was beneficial in this population (HR, 0.515 [95% CI, 0.316 to 0.838]; P =.0065). Those without detectable MRD showed no benefit (HR, 1.213 [95% CI, 0.616 to 2.387]; P =.575).CONCLUSIONAlthough the overall improvement in RFS was not statistically significant, RFS was higher for participants with detectable FLT3-ITD MRD pre- or post-HCT who received gilteritinib treatment. To our knowledge, these data are among the first to support the effectiveness of MRD-based post-HCT therapy.

Published
2024

16. Murine iPSC-derived microglia and macrophage cell culture models recapitulate distinct phenotypical and functional properties of classical and alternative neuro-immune polarisation

Author

Quarta, Alessandra, Le Blon, Debbie, D'aes, Tine, Pieters, Zoë, Hamzei Taj, Somayyeh, Miró-Mur, Francesc, Luyckx, Evi, Van Breedam, Elise, Daans, Jasmijn, Goossens, Herman, Dewilde, Sylvia, Hens, Niel, Pasque, Vincent, Planas, Anna M., Hoehn, Mathias, Berneman, Zwi, and Ponsaerts, Peter

Published
2019
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17. Integration of the PD-L1 inhibitor atezolizumab and WT1/DC vaccination into standard-of-care first-line treatment for patients with epithelioid malignant pleural mesothelioma—Protocol of the Immuno-MESODEC study.

Author

Van den Bossche, Jolien, De Laere, Maxime, Deschepper, Koen, Germonpré, Paul, Valcke, Yvan, Lamont, Jan, Stein, Barbara, Van Camp, Kirsten, Germonpré, Charlotte, Nijs, Griet, Roelant, Ella, Anguille, Sébastien, Lion, Eva, and Berneman, Zwi

Subjects
PLEURA, IMMUNE checkpoint inhibitors, ATEZOLIZUMAB, NEPHROBLASTOMA, PROGRAMMED death-ligand 1, VACCINATION
Abstract

Malignant pleural mesothelioma (MPM) is an aggressive cancer with a very poor prognosis. Recently, immune checkpoint inhibition (ICI) has taken center stage in the currently ongoing revolution that is changing standard-of-care treatment for several malignancies, including MPM. As multiple arguments and accumulating lines of evidence are in support of the existence of a therapeutic synergism between chemotherapy and immunotherapy, as well as between different classes of immunotherapeutics, we designed a multicenter, single-arm, phase I/II trial in which both programmed-death-ligand 1 (PD-L1) inhibition and dendritic cell (DC) vaccination are integrated in the first-line conventional platinum/pemetrexed-based treatment scheme for epithelioid MPM patients (Immuno-MESODEC, ClinicalTrials.gov identifier NCT05765084). Fifteen treatment-naïve patients with unresectable epithelioid subtype MPM will be treated with four 3-weekly (±3 days) chemo-immunotherapy cycles. Standard-of-care chemotherapy consisting of cisplatinum (75mg/m2) and pemetrexed (500mg/m2) will be supplemented with the anti-PD-L1 antibody atezolizumab (1200 mg) and autologous Wilms' tumor 1 mRNA-electroporated dendritic cell (WT1/DC) vaccination (8–10 x 106 cells/vaccination). Additional atezolizumab (1680 mg) doses and/or WT1/DC vaccinations (8–10 x 106 cells/vaccination) can be administered optionally following completion of the chemo-immunotherapy scheme. Follow-up of patients will last for up to 90 days after final atezolizumab administration and/or WT1/DC vaccination or 24 months after diagnosis, whichever occurs later. The trial's primary endpoints are safety and feasibility, secondary endpoints are clinical efficacy and immunogenicity. This phase I/II trial will evaluate whether addition of atezolizumab and WT1/DC vaccination to frontline standard-of-care chemotherapy for the treatment of epithelioid MPM is feasible and safe. If so, this novel combination strategy should be further investigated as a promising advanced treatment option for this hard-to-treat cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Correction to: Luminescent Human iPSC-Derived Neurospheroids Enable Modeling of Neurotoxicity After Oxygen–glucose Deprivation

Author

Van Breedam, Elise, Nijak, Aleksandra, Buyle-Huybrecht, Tamariche, Di Stefano, Julia, Boeren, Marlies, Govaerts, Jonas, Quarta, Alessandra, Swartenbroekx, Tine, Z. Jacobs, Eva, Menten, Björn, Gijsbers, Rik, Delputte, Peter, Alaerts, Maaike, Hassannia, Behrouz, Loeys, Bart, Berneman, Zwi, Timmermans, Jean-Pierre, G. Jorens, Philippe, Vanden Berghe, Tom, Fransen, Erik, Wouters, An, H. De Vos, Winnok, and Ponsaerts, Peter

Published
2022
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20. Analysis of Wilms' tumor protein 1 specific TCR repertoire in AML patients uncovers higher diversity in patients in remission than in relapsed

Author

Gielis, Sofie, primary, Flumens, Donovan, additional, van der Heijden, Sanne, additional, Versteven, Maarten, additional, De Reu, Hans, additional, Bartholomeus, Esther, additional, Schippers, Jolien, additional, Campillo-Davo, Diana, additional, Berneman, Zwi, additional, Anguille, Sébastien, additional, Smits, Evelien, additional, Ogunjimi, Benson, additional, Lion, Eva, additional, Laukens, Kris, additional, and Meysman, Pieter, additional

Published
2023
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21. Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia

Author

Anguille, Sébastien, Van de Velde, Ann L., Smits, Evelien L., Van Tendeloo, Viggo F., Juliusson, Gunnar, Cools, Nathalie, Nijs, Griet, Stein, Barbara, Lion, Eva, Van Driessche, Ann, Vandenbosch, Irma, Verlinden, Anke, Gadisseur, Alain P., Schroyens, Wilfried A., Muylle, Ludo, Vermeulen, Katrien, Maes, Marie-Berthe, Deiteren, Kathleen, Malfait, Ronald, Gostick, Emma, Lammens, Martin, Couttenye, Marie M., Jorens, Philippe, Goossens, Herman, Price, David A., Ladell, Kristin, Oka, Yoshihiro, Fujiki, Fumihiro, Oji, Yusuke, Sugiyama, Haruo, and Berneman, Zwi N.

Published
2017
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23. The immune microenvironment characterisation and dynamics in hormone receptor–positive breast cancer before and after neoadjuvant endocrine therapy

Author

Oner, Gizem, primary, Broeckx, Glenn, additional, Van Berckelaer, Christophe, additional, Zwaenepoel, Karen, additional, Altintas, Sevilay, additional, Canturk, Zafer, additional, Tjalma, Wiebren, additional, Berneman, Zwi, additional, Peeters, Marc, additional, Pauwels, Patrick, additional, and van Dam, Peter A., additional

Published
2023
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24. Disease Perception Is Correlated with Health-Related Quality of Life in Patients Suffering from Myelodysplastic Syndromes: Results of the Belgian Be-QUALMS Study

Author

Heyrman, Bert, primary, Meers, Stef, additional, De Becker, Ann, additional, Wouters, Kristien, additional, Van Hoof, Achiel, additional, Van De Velde, Ann, additional, Graux, Carlos, additional, Mazure, Dominiek, additional, Selleslag, Dominik, additional, Maes, Helena, additional, Lemmens, Jan, additional, Beckers, Marielle, additional, Breems, Dimitri, additional, Sid, Sélim, additional, Berneman, Zwi, additional, and Anguille, Sébastien, additional

Published
2023
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25. Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

Author

Derdelinckx, Judith, Mansilla, María José, De Laere, Maxime, Lee, Wai-Ping, Navarro-Barriuso, Juan, Wens, Inez, Nkansah, Irene, Daans, Jasmijn, De Reu, Hans, Jolanta Keliris, Aneta, Van Audekerke, Johan, Vanreusel, Verdi, Pieters, Zoë, Van der Linden, Annemie, Verhoye, Marleen, Molenberghs, Geert, Hens, Niel, Goossens, Herman, Willekens, Barbara, Cras, Patrick, Ponsaerts, Peter, Berneman, Zwi N., Martínez-Cáceres, Eva María, and Cools, Nathalie

Published
2019
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26. In vitro expansion of Wilms’ tumor protein 1 epitope-specific primary T cells from healthy human peripheral blood mononuclear cells

Author

van der Heijden, Sanne, primary, Flumens, Donovan, additional, Versteven, Maarten, additional, Peeters, Stefanie, additional, Reu, Hans De, additional, Campillo-Davo, Diana, additional, Willemen, Yannick, additional, Ogunjimi, Benson, additional, Van Tendeloo, Viggo, additional, Berneman, Zwi N., additional, Anguille, Sébastien, additional, Smits, Evelien, additional, and Lion, Eva, additional

Published
2023
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27. Abstract PD9-03: Breast Cancer Microenvironment Change After Neoadjuvant Endocrine Treatment Breast Cancer Microenvironment Change After Neoadjuvant Endocrine Treatment

Author

Oner, Gizem, primary, Broeckx, Glenn, additional, Van Berckelaer, Christophe, additional, Altintas, Sevilay, additional, Canturk, Zafer, additional, Tjalma, Wiebren, additional, Zwaenepoel, Karen, additional, Berneman, Zwi, additional, Peeters, Marc, additional, Pauwels, Patrick, additional, and van Dam, Peter A, additional

Published
2023
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33. Predictive model for BNT162b2 vaccine response in cancer patients based on blood cytokines and growth factors

Author

Konnova, Angelina, primary, De Winter, Fien H. R., additional, Gupta, Akshita, additional, Verbruggen, Lise, additional, Hotterbeekx, An, additional, Berkell, Matilda, additional, Teuwen, Laure-Anne, additional, Vanhoutte, Greetje, additional, Peeters, Bart, additional, Raats, Silke, additional, Massen, Isolde Van der, additional, De Keersmaecker, Sven, additional, Debie, Yana, additional, Huizing, Manon, additional, Pannus, Pieter, additional, Neven, Kristof Y., additional, Ariën, Kevin K., additional, Martens, Geert A., additional, Bulcke, Marc Van Den, additional, Roelant, Ella, additional, Desombere, Isabelle, additional, Anguille, Sébastien, additional, Berneman, Zwi, additional, Goossens, Maria E., additional, Goossens, Herman, additional, Malhotra-Kumar, Surbhi, additional, Tacconelli, Evelina, additional, Vandamme, Timon, additional, Peeters, Marc, additional, van Dam, Peter, additional, and Kumar-Singh, Samir, additional

Published
2022
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40. Analysis of von Willebrand Disease in the “Heart of Europe”

Author

Vangenechten, Inge, additional, Smejkal, Petr, additional, Zavrelova, Jiri, additional, Zapletal, Ondrej, additional, Wild, Alexander, additional, Michiels, Jan Jacques, additional, Berneman, Zwi, additional, Blatny, Jan, additional, Batorova, Angelika, additional, Prigancova, Tatiana, additional, Penka, Miroslav, additional, and Gadisseur, Alain, additional

Published
2022
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41. Predictive model for BNT162b2 vaccine response in cancer patients based on cytokines and growth factors

Author

Konnova, Angelina, primary, De Winter, Fien HR, additional, Gupta, Akshita, additional, Verbruggen, Lise, additional, Hotterbeekx, An, additional, Berkell, Matilda, additional, Teuwen, Laure-Anne, additional, Vanhoutte, Greetje, additional, Peeters, Bart, additional, Raats, Silke, additional, Van der Massen, Isolde, additional, De Keersmaecker, Sven, additional, Debie, Yana, additional, Huizing, Manon, additional, Pannus, Pieter, additional, Neven, Kristof Y, additional, Ariën, Kevin K, additional, Martens, Geert A., additional, Van Den Bulcke, Marc, additional, Roelant, Ella, additional, Desombere, Isabelle, additional, Anguille, Sébastien, additional, Berneman, Zwi, additional, Goossens, Maria E, additional, Goossens, Herman, additional, Malhotra-Kumar, Surbhi, additional, Taconelli, Evelina, additional, Vandamme, Timon, additional, Peeters, Marc, additional, van Dam, Peter, additional, and Kumar-Singh, Samir, additional

Published
2022
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45. Engineering monocyte-derived dendritic cells to secrete interferon-α enhances their ability to promote adaptive and innate anti-tumor immune effector functions

Author

Willemen, Yannick, Van den Bergh, Johan M. J., Lion, Eva, Anguille, Sébastien, Roelandts, Vicky A. E., Van Acker, Heleen H., Heynderickx, Steven D. I., Stein, Barbara M. H., Peeters, Marc, Figdor, Carl G., Van Tendeloo, Viggo F. I., de Vries, I. Jolanda, Adema, Gosse J., Berneman, Zwi N., and Smits, Evelien L. J.

Published
2015
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48. Trial watch: Dendritic cell (DC)-based immunotherapy for cancer

Author

Laureano, Raquel S, primary, Sprooten, Jenny, additional, Vanmeerbeerk, Isaure, additional, Borras, Daniel M, additional, Govaerts, Jannes, additional, Naulaerts, Stefan, additional, Berneman, Zwi N, additional, Beuselinck, Benoit, additional, Bol, Kalijn F, additional, Borst, Jannie, additional, Coosemans, an, additional, Datsi, Angeliki, additional, Fučíková, Jitka, additional, Kinget, Lisa, additional, Neyns, Bart, additional, Schreibelt, Gerty, additional, Smits, Evelien, additional, Sorg, Rüdiger V, additional, Spisek, Radek, additional, Thielemans, Kris, additional, Tuyaerts, Sandra, additional, De Vleeschouwer, Steven, additional, de Vries, I Jolanda M, additional, Xiao, Yanling, additional, and Garg, Abhishek D, additional

Published
2022
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50. Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

Author

Van Tendeloo, Viggo F., Van de Velde, Ann, Van Driessche, Ann, Cools, Nathalie, Anguille, Sébastien, Ladell, Kristin, Gostick, Emma, Vermeulen, Katrien, Pieters, Katrien, Nijs, Griet, Stein, Barbara, Smits, Evelien L., Schroyens, Wilfried A., Gadisseur, Alain P., Vrelust, Inge, Jorens, Philippe G., Goossens, Herman, de Vries, I. Jolanda, Price, David A., Oji, Yusuke, Oka, Yoshihiro, Sugiyama, Haruo, Berneman, Zwi N., and Akira, Shizuo

Published
2010

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