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1. Limited antibody response after BA.4‐5 adapted booster vaccination in rheumatic patients receiving anti‐TNF therapy: Results of a case series

Author

Geisen, Ulf M., primary, Voß, Mathias, additional, Rose, Ruben, additional, Neumann, Franziska, additional, Bäumler, Carina, additional, Müller, Sina, additional, Paltzow, Lea, additional, Christophersen, Christina M., additional, Münier, Merle, additional, Hildebrand, Elena, additional, Hoff, Paula, additional, Longardt, Ann C., additional, Lorentz, Thomas, additional, Schirmer, Jan H., additional, Sümbül, Melike, additional, Tran, Florian, additional, Berner, Dennis, additional, Fickenscher, Helmut, additional, Gerdes, Sascha, additional, Schreiber, Stefan, additional, Krumbholz, Andi, additional, and Hoyer, Bimba F., additional

Published
2023
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2. The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination

Author

Saggau, Carina, primary, Martini, Gabriela Rios, additional, Rosati, Elisa, additional, Meise, Silja, additional, Messner, Berith, additional, Kamps, Ann-Kristin, additional, Bekel, Nicole, additional, Gigla, Johannes, additional, Rose, Ruben, additional, Voß, Mathias, additional, Geisen, Ulf M., additional, Reid, Hayley M., additional, Sümbül, Melike, additional, Tran, Florian, additional, Berner, Dennis K., additional, Khodamoradi, Yascha, additional, Vehreschild, Maria J.G.T., additional, Cornely, Oliver, additional, Koehler, Philipp, additional, Krumbholz, Andi, additional, Fickenscher, Helmut, additional, Kreuzer, Oliver, additional, Schreiber, Claudia, additional, Franke, Andre, additional, Schreiber, Stefan, additional, Hoyer, Bimba, additional, Scheffold, Alexander, additional, and Bacher, Petra, additional

Published
2022
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3. Stark reduzierte Impftiter nach mRNA SARS-CoV-2 Impfung bei Patienten unter TNF-Blocker Therapie

Author

Geisen, Ulf, Sümbül, Melike, Tran, Florian, Berner, Dennis, Reid, Hayley, Vullriede, Lena, Ciripoi, Maria, Longardt, Ann, Hoff, Paula, Morrison, Peter, Schneider, Verena, Zeuner, Rainald, Schirmer, Jan, Steinbach, Andrea, Nikolaus, Susanna, Gerdes, Sascha, Schreiber, Stefan, and Bacher, Petra

Subjects
Medicine and health
Abstract

Einleitung: Impfungen gegen SARS-CoV-2 sind das Mittel der Wahl bei der Bekämpfung der Covid-19-Pandemie. Dennoch gibt es nach der Einführung der neuartigen mRNA Impfstoffe immer noch Unsicherheiten bezüglich der Wirksamkeit bei Patienten mit bestimmten Grunderkrankungen oder Therapien. [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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4. The long term vaccine‐induced anti‐SARS‐CoV‐2 immune response is impaired in quantity and quality under TNFα blockade

Author

Geisen, Ulf Martin, primary, Rose, Ruben, additional, Neumann, Franziska, additional, Ciripoi, Maria, additional, Vullriede, Lena, additional, Reid, Hayley M., additional, Berner, Dennis Kristopher, additional, Bertoglio, Federico, additional, Hoff, Paula, additional, Hust, Michael, additional, Longardt, Ann Carolin, additional, Lorentz, Thomas, additional, Martini, Gabriela Rios, additional, Saggau, Carina, additional, Schirmer, Jan Henrik, additional, Schubert, Maren, additional, Sümbül, Melike, additional, Tran, Florian, additional, Voß, Mathias, additional, Zeuner, Rainald, additional, Morrison, Peter J., additional, Bacher, Petra, additional, Fickenscher, Helmut, additional, Gerdes, Sascha, additional, Peipp, Matthias, additional, Schreiber, Stefan, additional, Krumbholz, Andi, additional, and Hoyer, Bimba Franziska, additional

Published
2022
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5. Multiple effects of TNFα inhibitors on the development of the adaptive immune response after SARS-CoV-2 vaccination

Author

Geisen, Ulf Martin, primary, Rose, Ruben, additional, Neumann, Franziska, additional, Ciripoi, Maria, additional, Vullriede, Lena, additional, Reid, Hayley M, additional, Berner, Dennis Kristopher, additional, Bertoglio, Federico, additional, Hoff, Paula, additional, Hust, Michael, additional, Longardt, Ann Carolin, additional, Lorentz, Thomas, additional, Rios Martini, Gabriela, additional, Saggau, Carina, additional, Schirmer, Jan Henrik, additional, Schubert, Maren, additional, Suembuel, Melike, additional, Tran, Florian, additional, Voss, Mathias, additional, Zeuner, Rainald, additional, Morrison, Peter J, additional, Bacher, Petra, additional, Fickenscher, Helmut, additional, Gerdes, Sascha, additional, Peipp, Matthias, additional, Schreiber, Stefan, additional, Krumbholz, Andi, additional, and Hoyer, Bimba Franziska, additional

Published
2022
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6. The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination

Author

Saggau, Carina, Martini, Gabriela Rios, Rosati, Elisa, Meise, Silja, Messner, Berith, Kamps, Ann-Kristin, Bekel, Nicole, Gigla, Johannes, Rose, Ruben, Voss, Mathias, Geisen, Ulf M., Reid, Hayley M., Sumbul, Melike, Tran, Florian, Berner, Dennis K., Khodamoradi, Yascha, Vehreschild, Maria J. G. T., Cornely, Oliver, Koehler, Philipp, Krumbholz, Andi, Fickenscher, Helmut, Kreuzer, Oliver, Schreiber, Claudia, Franke, Andre, Schreiber, Stefan, Hoyer, Bimba, Scheffold, Alexander, Bacher, Petra, Saggau, Carina, Martini, Gabriela Rios, Rosati, Elisa, Meise, Silja, Messner, Berith, Kamps, Ann-Kristin, Bekel, Nicole, Gigla, Johannes, Rose, Ruben, Voss, Mathias, Geisen, Ulf M., Reid, Hayley M., Sumbul, Melike, Tran, Florian, Berner, Dennis K., Khodamoradi, Yascha, Vehreschild, Maria J. G. T., Cornely, Oliver, Koehler, Philipp, Krumbholz, Andi, Fickenscher, Helmut, Kreuzer, Oliver, Schreiber, Claudia, Franke, Andre, Schreiber, Stefan, Hoyer, Bimba, Scheffold, Alexander, and Bacher, Petra

Abstract

SARS-CoV-2 infection and vaccination generates enormous host-response heterogeneity and an age -dependent loss of immune-response quality. How the pre-exposure T cell repertoire contributes to this heterogeneity is poorly understood. We combined analysis of SARS-CoV-2-specific CD4+ T cells pre-and post-vaccination with longitudinal T cell receptor tracking. We identified strong pre-exposure T cell variability that correlated with subsequent immune-response quality and age. High-quality responses, defined by strong expansion of high-avidity spike-specific T cells, high interleukin-21 production, and specific immuno-globulin G, depended on an intact naive repertoire and exclusion of pre-existing memory T cells. In the elderly, T cell expansion from both compartments was severely compromised. Our results reveal that an intrinsic defect of the CD4+ T cell repertoire causes the age-dependent decline of immune-response quality against SARS-CoV-2 and highlight the need for alternative strategies to induce high-quality T cell responses against newly arising pathogens in the elderly.

Published
2022

7. Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapies

Author

Geisen, Ulf M, primary, Sümbül, Melike, additional, Tran, Florian, additional, Berner, Dennis K, additional, Reid, Hayley M, additional, Vullriede, Lena, additional, Ciripoi, Maria, additional, Longardt, Ann C, additional, Hoff, Paula, additional, Morrison, Peter J, additional, Schneider, Verena E, additional, Zeuner, Rainald, additional, Schirmer, Jan H, additional, Steinbach, Andrea, additional, Nikolaus, Susanna, additional, Gerdes, S, additional, Schreiber, Stefan, additional, Bacher, Petra, additional, and Hoyer, Bimba F, additional

Published
2021
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8. Immunogenicity and safety of anti-SARS-CoV-2 mRNA vaccines in patients with chronic inflammatory conditions and immunosuppressive therapy in a monocentric cohort

Author

Geisen, Ulf M, primary, Berner, Dennis K, additional, Tran, Florian, additional, Sümbül, Melike, additional, Vullriede, Lena, additional, Ciripoi, Maria, additional, Reid, Hayley M, additional, Schaffarzyk, Annika, additional, Longardt, Ann C, additional, Franzenburg, Jeanette, additional, Hoff, Paula, additional, Schirmer, Jan H, additional, Zeuner, Rainald, additional, Friedrichs, Anette, additional, Steinbach, Andrea, additional, Knies, Christine, additional, Markewitz, Robert DH, additional, Morrison, Peter J, additional, Gerdes, Sascha, additional, Schreiber, Stefan, additional, and Hoyer, Bimba F, additional

Published
2021
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9. Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages

Author

Berner, Dennis Kristopher, primary, Wessolowski, Luisa, additional, Armbrust, Fred, additional, Schneppenheim, Janna, additional, Schlepckow, Kai, additional, Koudelka, Tomas, additional, Scharfenberg, Franka, additional, Lucius, Ralph, additional, Tholey, Andreas, additional, Kleinberger, Gernot, additional, Haass, Christian, additional, Arnold, Philipp, additional, and Becker‐Pauly, Christoph, additional

Published
2020
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10. Anti‐TNF therapy impairs both short‐ and long‐term IgG responses after repeated vaccination.

Author

Buhre, Jana Sophia, Pongracz, Tamas, Geisen, Ulf Martin, Schubert, Mareike, Wang, Wenjun, Nouta, Jan, Obara, Maureen, Lehrian, Selina, Rahmöller, Johann, Petry, Janina, Tran, Florian, Schreiber, Stefan, Sümbül, Melike, Berner, Dennis, Gerdes, Sascha, Schirmer, Jan, Longardt, Ann Carolin, Hoff, Paula, Kalinke, Ulrich, and Ludwig, Ralf J.

Subjects
*IMMUNOGLOBULIN G, *IMMUNOLOGIC memory, *GERMINAL centers, *BOOSTER vaccines, *VACCINE effectiveness, *IMMUNE reconstitution inflammatory syndrome, *HEPATITIS B
Abstract

Background Methods Results Conclusions Recently, it has been questioned whether vaccination of patients with inflammatory (auto)immune diseases under anti‐tumor necrosis factor (TNF) treatment leads to impaired vaccine‐induced immune responses and protection against breakthrough infections. However, the effects of TNF blockade on short‐ and long‐term immune responses after repeated vaccination remain unclear. Vaccination studies have shown that initial short‐term IgG antibodies (Abs) carry highly galactosylated and sialylated Fc glycans, whilst long‐term IgG Abs have low levels of galactosylation and sialylation and are most likely generated by long‐lived plasma cells (PCs) derived primarily from the germinal center (GC) response. Thus, IgG Fc glycosylation patterns may be applicable to distinguish short‐ and long‐term vaccine responses after repeated vaccination under the influence of anti‐TNF treatment.We used COVID‐19 vaccination as a model to investigate vaccine‐induced IgG subclass levels and Fc glycosylation patterns, B cell subsets, and effector functions of short‐ and long‐term Ab responses after up to three vaccinations in patients on anti‐TNF or other immunosuppressive treatments and in healthy individuals. Using TriNetX, a global healthcare database, we determined the risk of SARS‐CoV‐2 breakthrough infections in vaccinated patients treated with anti‐TNF or other immunosuppressive drugs.Anti‐TNF treatment reduced the long‐term abundance of all anti‐S IgG subclasses with low levels of galactosylation and sialylation. Re‐activation of potential memory B cells initially generated highly galactosylated and sialylated IgG antibodies, which were progressively reduced after each booster dose in anti‐TNF‐treated patients, especially in the elderly. The reduced short‐ and long‐term IgG (1) levels in anti‐TNF‐treated patients correlated with diminished functional activity and an increased risk for the development of COVID‐19.The data suggest that anti‐TNF treatment reduces both GC‐dependent long‐lived PCs and GC‐dependent memory B cell‐derived short‐lived PCs, hence both the long‐ and short‐term IgG subclass responses, respectively, after repeated vaccination. We propose that anti‐TNF therapy, especially in the elderly, reduces the benefit of booster vaccination. [ABSTRACT FROM AUTHOR]

Published
2024
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