Search

Your search keyword '"Bernhardt R"' showing total 842 results
Start Over Author "Bernhardt R"
842 results on '"Bernhardt R"'

2. Comparison of Microfocus- and Synchrotron X-ray Tomography for the Analysis of Osteointegration around Ti6Al4V-Implants

Author

Bernhardt R., Scharnweber D., Müller B., Thurner P., Schliephake H., Wyss P., Beckmann F., Goebbels J., and Worch H.

Subjects
Diseases of the musculoskeletal system, RC925-935, Orthopedic surgery, RD701-811
Abstract

Micro-computed tomography (µCT) provides quantitative three-dimensional information of bone around titanium implants similar to classical histology. The study, based on an animal model, containing cuboid-shaped biofunctionalised Ti6Al4V implants with surrounding bone after 4 weeks, is performed using 3 µCT-systems with X-ray tubes, one synchrotron-radiation-based µCT-system (SRµCT), and classical histology. Although the spatial resolution of the µCT-systems is comparable, only the results of SRµCT agree with results of classical histology. The X-ray tube sources give rise to huge artefacts in the tomograms (interface scattering, beam hardening), which impaired the quantitative analysis of bone up to about 200µm from the implant surface. Due to the non-destructive character of µCT the specimens can be subsequently examined by classical histology without restriction. The quantitative comparison of bone formation uncovers the strong dependence of the newly formed bone from the selected slice. This implies the necessity of 3D analysis. SRµCT and classical histology prove that surface modifications of the titanium implant significantly influence the bone formation. Using SRµCT, the preparation artefacts due to cutting and polishing are excluded.

Published
2004

3. Atomic Force Microscopy Study of Protein–Protein Interactions in the Cytochrome CYP11A1 (P450scc)-Containing Steroid Hydroxylase System

Author

Zöllner A, Reinle W, Bernhardt R, Ivanov YD, Frantsuzov PA, Medvedeva NV, and Archakov AI

Subjects
Atomic force microscopy, Photon correlation spectroscopy, Cytochrome CYP11A1, Monomerization, Complex formation, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Abstract Atomic force microscopy (AFM) and photon correlation spectroscopy (PCS) were used for monitoring of the procedure for cytochrome CYP11A1 monomerization in solution without phospholipids. It was shown that the incubation of 100 μM CYP11A1 with 12% Emulgen 913 in 50 mM KP, pH 7.4, for 10 min at T = 22°C leads to dissociation of hemoprotein aggregates to monomers with the monomerization degree of (82 ± 4)%. Following the monomerization procedure, CYP11A1 remained functionally active. AFM was employed to detect and visualize the isolated proteins as well as complexes formed between the components of the cytochrome CYP11A1-dependent steroid hydroxylase system. Both Ad and AdR were present in solution as monomers. The typical heights of the monomeric AdR, Ad and CYP11A1 images were measured by AFM and were found to correspond to the sizes 1.6 ± 0.2 nm, 1.0 ± 0.2 nm and 1.8 ± 0.2 nm, respectively. The binary Ad/AdR and AdR/CYP11A1mon complexes with the heights 2.2 ± 0.2 nm and 2.8 ± 0.2 nm, respectively, were registered by use of AFM. The Ad/CYP11A1mon complex formation reaction was kinetically characterized based on optical biosensor data. In addition, the ternary AdR/Ad/CYP11A1 complexes with a typical height of 4 ± 1 nm were AFM registered.

Published
2011

4. Cavitation in Rubber Vulcanizates Subjected to Constrained Tensile Deformation

Author

Euchler, E., Bernhardt, R., Schneider, K., Heinrich, G., Tada, T., Wießner, S., Stommel, M., Abe, Akihiro, Editorial Board Member, Albertsson, Ann-Christine, Editorial Board Member, Coates, Geoffrey W, Editorial Board Member, Genzer, Jan, Editorial Board Member, Kobayashi, Shiro, Editorial Board Member, Lee, Kwang-Sup, Editorial Board Member, Leibler, Ludwik, Editorial Board Member, Long, Timothy E., Editorial Board Member, Möller, Martin, Editorial Board Member, Okay, Oguz, Editorial Board Member, Percec, Virgil, Editorial Board Member, Tang, Ben Zhong, Editorial Board Member, Terentjev, Eugene M., Editorial Board Member, Theato, Patrick, Editorial Board Member, Voit, Brigitte, Editorial Board Member, Wiesner, Ulrich, Editorial Board Member, Zhang, Xi, Editorial Board Member, Heinrich, Gert, editor, Kipscholl, Reinhold, editor, and Stoček, Radek, editor

Published
2021
Full Text
View/download PDF

5. Dielectric Strength and Aging Performance of Polybutylene Terephthalate (PBT) Under the Influence of Temperature and Humidity

Author

Wels, S., Boettge, B., Bernhardt, R., Klengel, S., Claudi, A., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martin, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, and Németh, Bálint, editor

Published
2020
Full Text
View/download PDF

18. CYP106A1

Author

Carius, Y., primary, Hutter, M., additional, Kiss, F., additional, Bernhardt, R., additional, and Lancaster, C.R.D., additional

Published
2022
Full Text
View/download PDF

19. Software Solutions for ICME

Author

Schmitz, G. J., Engstrom, A., Bernhardt, R., Prahl, U., Adam, L., Seyfarth, J., Apel, M., de Saracibar, C. Agelet, Korzhavyi, P., Ågren, J., and Patzak, B.

Published
2016
Full Text
View/download PDF

21. Dataset of a retrospective multicenter cohort study on characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis.

Author

Müller-Jensen, L, Zierold, S, Versluis, JM, Boehmerle, W, Huehnchen, P, Endres, M, Mohr, R, Compter, A, Blank, CU, Hagenacker, T, Meier, F, Reinhardt, L, Gesierich, A, Salzmann, M, Hassel, JC, Ugurel, S, Zimmer, L, Banks, P, Spain, L, Soon, JA, Enokida, T, Tahara, M, Kähler, KC, Seggewiss-Bernhardt, R, Harvey, C, Long, GV, Schöberl, F, von Baumgarten, L, Hundsberger, T, Schlaak, M, French, LE, Knauss, S, Heinzerling, LM, Müller-Jensen, L, Zierold, S, Versluis, JM, Boehmerle, W, Huehnchen, P, Endres, M, Mohr, R, Compter, A, Blank, CU, Hagenacker, T, Meier, F, Reinhardt, L, Gesierich, A, Salzmann, M, Hassel, JC, Ugurel, S, Zimmer, L, Banks, P, Spain, L, Soon, JA, Enokida, T, Tahara, M, Kähler, KC, Seggewiss-Bernhardt, R, Harvey, C, Long, GV, Schöberl, F, von Baumgarten, L, Hundsberger, T, Schlaak, M, French, LE, Knauss, S, and Heinzerling, LM

Abstract

Over the past decade, cancer immunotherapy with immune checkpoint inhibitors (ICIs) has significantly improved the outcome of many malignancies. However, with the broad use of ICIs, neurological immune related adverse events (irAE) are increasingly recognized. ICI-induced encephalitis (ICI-iE) is a particularly severe irAE, often leading to treatment termination, long-term sequalae or death. Despite its high morbidity and mortality, data on clinical features and diagnostic criteria are limited. We aimed to define clinical, radiologic and laboratory characteristics of ICI-iE and identify factors that discriminate it from anti-leucine-rich glioma-inactivated (anti-LGI)-1 encephalitis and herpes simplex virus (HSV)-1 encephalitis - two alternative causes of encephalitis - to increase the awareness of ICI-iE and improve its diagnosis and management. To that end, we retrospectively collected 30 cases of ICI-iE that were reported to the Side Effect Registry Immuno-Oncology (SERIO) and 46 cases of anti-LGI1 encephalitis or herpes simplex virus (HSV)-1 encephalitis that presented to a large German neurological referral center (Charité Universitätsmedizin Berlin) between January 2015 and September 2021. Signs and symptoms, imaging and electroencephalogram features, laboratory findings and outcome measures were assessed using standardized case report forms as well as patients' medical records and compared between the groups. The data reported here represents the largest primary cohort of patients with ICI-iE to date and the first comparison with other types of encephalitis. As all three disorders - ICI-iE, HSV-1 encephalitis and anti-LGI1 encephalitis - are rare neurological entities, this dataset can be used as a reference in future clinical studies on ICI-induced neurotoxicity, neurological autoimmune disorders, and central nervous system infections.

Published
2022

31. Program execution

Author

Schröer, K., Bernhardt, R., Bernhardt, Rolf, editor, Dillman, Rüdiger, editor, Hörmann, Klaus, editor, and Tierney, K., editor

Published
1992
Full Text
View/download PDF

32. Process execution simulation

Author

Katschinski, V., Schreck, G., Bernhardt, R., Bernhardt, Rolf, editor, Dillman, Rüdiger, editor, Hörmann, Klaus, editor, and Tierney, K., editor

Published
1992
Full Text
View/download PDF

36. Report on the validation of a demonstrator for the exchange of dimensional measurements in an end user application, with a secure logistic data chain including DCCs

Author

Mustapää, T., Immonen, L., Tunkkari, H., Taponen, J., Parkkinen, L., Pousi, J., Hutzschenreuter, D., Heeren, W., Brown, C., Baer, O., Bernhardt, R., Stein, K., Haller, J., and Müller-Schöll, C.

Subjects
Validation, Cryptography, D-SI, Digital Signature, DCC
Abstract

In this deliverable report of SmartCom project we introduce a demonstrator for exchanging metrological data in a smart overhead crane. The demonstrator showcases the use of Digital Calibration Certificates (DCC), Digital SI (D-SI) and appropriate cryptographical methods such as digital signatures and Distributed Ledger Technology (DLT), a.k.a. a blockchain, for secure exchange of measurement data and relevant metadata of cargo containers., The SmartCom project 17IND02 has received funding from the EMPIR programme co-financed by the Participating States and from the European Union's Horizon 2020 research and innovation programme.

Published
2021
Full Text
View/download PDF

42. Structure of the Book

Author

Bernhardt, R., Bernhardt, Rolf, editor, Dillman, Rüdiger, editor, Hörmann, Klaus, editor, and Tierney, K., editor

Published
1992
Full Text
View/download PDF

43. Robots in CIM

Author

Bernhardt, R., Bernhardt, Rolf, editor, Dillman, Rüdiger, editor, Hörmann, Klaus, editor, and Tierney, K., editor

Published
1992
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results