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1. Socioeconomic conditions and children's mental health and quality of life during the COVID-19 pandemic: An intersectional analysis

Author

Amrein, Deborah, Arm-Vernez, Isabelle, Azman, Andrew S., Bal, Antoine, Balavoine, Michael, Barbe, Rémy P., Baysson, Hélène, Berthelot, Julie, Bleich, Patrick, Boehm, Livia, Bouchet, Aminata R., Bryand, Gaëlle, Bucolli, Viola, Collombet, Prune, Cudet, Alain, Davidovic, Vladimir, de Mestral, Carlos, D’Ippolito, Paola, Dubos, Richard, Dumont, Roxane, Eckerle, Isabella, El Merjani, Nacira, Favier, Marion, Francioli, Natalie, Graindorge, Clément, Guessous, Idris, Hagose, Munire, Harnal, Séverine, Hurst, Samia, Kaiser, Laurent, Kherad, Omar, Lamour, Julien, Lescuyer, Pierre, L’Huillier, Arnaud G., Loizeau, Andrea, Lorthe, Elsa, Martinez, Chantal, Mermet, Stéphanie, Nehme, Mayssam, Noël, Natacha, Pennacchio, Francesco, Perez-Saez, Javier, Perrin, Anne, Pittet, Didier, Posfay-Barbe, Klara M., Portier, Jane, Poulain, Géraldine, Pugin, Caroline, Pullen, Nick, Richard, Viviane, Rinaldi, Frederic, Rochat, Deborah, Sahyoun, Cyril, Sakvarelidze, Irine, Samir, Khadija, Santa Ramirez, Hugo Alejandro, Rizzo, Jessica, Schrempft, Stephanie, Semaani, Claire, Stringhini, Silvia, Testini, Stéphanie, Tisserand, Yvain, Rivas, Deborah Urrutia, Verolet, Charlotte, Villers, Jennifer, Violot, Guillemette, Vuilleumier, Nicolas, Yerly, Sabine, Zaballa, María-Eugenia, Zavlanou, Christina, and Zaballa, Maria-Eugenia

Published
2023
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2. Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study

Author

Arm-Vernez, Isabelle, Azman, Andrew S, Bachmann, Delphine, Bal, Antoine, Balavoine, Jean-François, Balavoine, Michael, Barbe, Rémy P, Baysson, Hélène, Beigbeder, Lison, Berthelot, Julie, Bleich, Patrick, Boehm, Livia, Bryand, Gaëlle, Chappuis, François, Collombet, Prune, Coudurier-Boeuf, Sophie, Courvoisier, Delphine, Cudet, Alain, Davidovic, Vladimir, de Mestral, Carlos, D'ippolito, Paola, Dubos, Richard, Dumont, Roxane, Eckerle, Isabella, El Merjani, Nacira, Flahault, Antoine, Francioli, Natalie, Frangville, Marion, Graindorge, Clément, Guessous, Idris, Harnal, Séverine, Hurst, Samia, Kaiser, Laurent, Kherad, Omar, Lamour, Julien, Lescuyer, Pierre, L'Huillier, Arnaud G, L'Huissier, François, Loizeau, Andrea Jutta, Lorthe, Elsa, Martinez, Chantal, Ménard, Lucie, Metral-Boffod, Ludovic, Moulin, Alexandre, Nehme, Mayssam, Noël, Natacha, Pennacchio, Francesco, Perez-Saez, Javier, Pittet, Didier, Posfay-Barbe, Klara M, Poulain, Géraldine, Pugin, Caroline, Pullen, Nick, Richard, Viviane, Rinaldi, Frederic, Rochat, Déborah, Sakvarelidze, Irine, Samir, Khadija, Ramirez, Hugo Santa, Satin, Etienne, Schaller, Philippe, Schibler, Manuel, Schrempft, Stephanie, Semaani, Claire, Stringhini, Silvia, Testini, Stéphanie, Trono, Didier, Urrutia-Rivas, Déborah, Verolet, Charlotte, Vetter, Pauline, Villers, Jennifer, Violot, Guillemette, Vuilleumier, Nicolas, Wisniak, Ania, Yerly, Sabine, Zaballa, María-Eugenia, Turelli, Priscilla, Raclot, Charlène, Duc, Julien, Azman, Andrew S., and Posfay-Barbe, Klara M.

Published
2023
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3. Socioeconomic conditions and children's mental health and quality of life during the COVID-19 pandemic: An intersectional analysis

Author

Lorthe, Elsa, primary, Richard, Viviane, additional, Dumont, Roxane, additional, Loizeau, Andrea, additional, Perez-Saez, Javier, additional, Baysson, Hélène, additional, Zaballa, Maria-Eugenia, additional, Lamour, Julien, additional, Pullen, Nick, additional, Schrempft, Stephanie, additional, Barbe, Rémy P., additional, Posfay-Barbe, Klara M., additional, Guessous, Idris, additional, Stringhini, Silvia, additional, Amrein, Deborah, additional, Arm-Vernez, Isabelle, additional, Azman, Andrew S., additional, Bal, Antoine, additional, Balavoine, Michael, additional, Berthelot, Julie, additional, Bleich, Patrick, additional, Boehm, Livia, additional, Bouchet, Aminata R., additional, Bryand, Gaëlle, additional, Bucolli, Viola, additional, Collombet, Prune, additional, Cudet, Alain, additional, Davidovic, Vladimir, additional, de Mestral, Carlos, additional, D’Ippolito, Paola, additional, Dubos, Richard, additional, Eckerle, Isabella, additional, El Merjani, Nacira, additional, Favier, Marion, additional, Francioli, Natalie, additional, Graindorge, Clément, additional, Hagose, Munire, additional, Harnal, Séverine, additional, Hurst, Samia, additional, Kaiser, Laurent, additional, Kherad, Omar, additional, Lescuyer, Pierre, additional, L’Huillier, Arnaud G., additional, Lorthe, Elsa, additional, Martinez, Chantal, additional, Mermet, Stéphanie, additional, Nehme, Mayssam, additional, Noël, Natacha, additional, Pennacchio, Francesco, additional, Perrin, Anne, additional, Pittet, Didier, additional, Portier, Jane, additional, Poulain, Géraldine, additional, Pugin, Caroline, additional, Rinaldi, Frederic, additional, Rochat, Deborah, additional, Sahyoun, Cyril, additional, Sakvarelidze, Irine, additional, Samir, Khadija, additional, Santa Ramirez, Hugo Alejandro, additional, Rizzo, Jessica, additional, Semaani, Claire, additional, Testini, Stéphanie, additional, Tisserand, Yvain, additional, Rivas, Deborah Urrutia, additional, Verolet, Charlotte, additional, Villers, Jennifer, additional, Violot, Guillemette, additional, Vuilleumier, Nicolas, additional, Yerly, Sabine, additional, Zaballa, María-Eugenia, additional, and Zavlanou, Christina, additional

Published
2023
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4. From alpha to omicron: how variants shaped sars-cov-2 school transmission

Author

Perez-Saez, Javier, primary, Bellon, Mathilde, additional, Azman Johns, Andrew, additional, Berthelot, Julie, additional, Hodcroft, Emma, additional, Zaballa, Maria-Eugenia, additional, Baysson, Hélène, additional, Pennacchio, Francesco, additional, Geneva, Julien, additional, L’Huillier, Arnaud, additional, Posfay-Barbe, Klara, additional, Maerckl, Sebastian, additional, Gessous, Idris, additional, Eckerle, Isabella, additional, Stringhini, Silvia, additional, and Lorthe, Elsa, additional

Published
2023
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5. Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study

Author

Zaballa, María-Eugenia, primary, Perez-Saez, Javier, additional, de Mestral, Carlos, additional, Pullen, Nick, additional, Lamour, Julien, additional, Turelli, Priscilla, additional, Raclot, Charlène, additional, Baysson, Hélène, additional, Pennacchio, Francesco, additional, Villers, Jennifer, additional, Duc, Julien, additional, Richard, Viviane, additional, Dumont, Roxane, additional, Semaani, Claire, additional, Loizeau, Andrea Jutta, additional, Graindorge, Clément, additional, Lorthe, Elsa, additional, Balavoine, Jean-François, additional, Pittet, Didier, additional, Schibler, Manuel, additional, Vuilleumier, Nicolas, additional, Chappuis, François, additional, Kherad, Omar, additional, Azman, Andrew S., additional, Posfay-Barbe, Klara M., additional, Kaiser, Laurent, additional, Trono, Didier, additional, Stringhini, Silvia, additional, Guessous, Idris, additional, Arm-Vernez, Isabelle, additional, Azman, Andrew S, additional, Bachmann, Delphine, additional, Bal, Antoine, additional, Balavoine, Michael, additional, Barbe, Rémy P, additional, Beigbeder, Lison, additional, Berthelot, Julie, additional, Bleich, Patrick, additional, Boehm, Livia, additional, Bryand, Gaëlle, additional, Collombet, Prune, additional, Coudurier-Boeuf, Sophie, additional, Courvoisier, Delphine, additional, Cudet, Alain, additional, Davidovic, Vladimir, additional, D'ippolito, Paola, additional, Dubos, Richard, additional, Eckerle, Isabella, additional, El Merjani, Nacira, additional, Flahault, Antoine, additional, Francioli, Natalie, additional, Frangville, Marion, additional, Harnal, Séverine, additional, Hurst, Samia, additional, Lescuyer, Pierre, additional, L'Huillier, Arnaud G, additional, L'Huissier, François, additional, Martinez, Chantal, additional, Ménard, Lucie, additional, Metral-Boffod, Ludovic, additional, Moulin, Alexandre, additional, Nehme, Mayssam, additional, Noël, Natacha, additional, Posfay-Barbe, Klara M, additional, Poulain, Géraldine, additional, Pugin, Caroline, additional, Rinaldi, Frederic, additional, Rochat, Déborah, additional, Sakvarelidze, Irine, additional, Samir, Khadija, additional, Ramirez, Hugo Santa, additional, Satin, Etienne, additional, Schaller, Philippe, additional, Schrempft, Stephanie, additional, Testini, Stéphanie, additional, Urrutia-Rivas, Déborah, additional, Verolet, Charlotte, additional, Vetter, Pauline, additional, Violot, Guillemette, additional, Wisniak, Ania, additional, Yerly, Sabine, additional, and Zaballa, María-Eugenia, additional

Published
2023
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7. Impact of the COVID-19 pandemic on children and adolescents: determinants and association with quality of life and mental health—a cross-sectional study.

Author

Richard, Viviane, Dumont, Roxane, Lorthe, Elsa, Loizeau, Andrea, Baysson, Hélène, Zaballa, María-Eugenia, Pennacchio, Francesco, Barbe, Rémy P., Posfay-Barbe, Klara M., Guessous, Idris, Stringhini, Silvia, Amrein, Deborah, Arm-Vernez, Isabelle, Azman, Andrew S., Bal, Antoine, Balavoine, Michael, Berthelot, Julie, Bleich, Patrick, Boehm, Livia, and Bryand, Gaëlle

Subjects
LIFESTYLES, KRUSKAL-Wallis Test, STATISTICS, SEDENTARY lifestyles, CONFIDENCE intervals, RESEARCH evaluation, CROSS-sectional method, SELF-evaluation, ECONOMIC status, MENTAL health, FAMILIES, CRONBACH'S alpha, SCREEN time, QUALITY of life, DESCRIPTIVE statistics, QUESTIONNAIRES, SCALE analysis (Psychology), HEALTH behavior, CHI-squared test, RESEARCH funding, SOCIODEMOGRAPHIC factors, STATISTICAL models, LOGISTIC regression analysis, ODDS ratio, DATA analysis, DATA analysis software, PARENT-child relationships, COVID-19 pandemic
Abstract

Background: The medium-term impact of the COVID-19 pandemic on the wellbeing of children and adolescents remains unclear. More than 2 years into the pandemic, we aimed to quantify the frequency and determinants of having been severely impacted by the COVID-19 pandemic and estimate its impact on health-related quality of life (HRQoL) and mental health. Methods: Data was drawn from a population-based cohort of children and adolescents, recruited between December 2021 and June 2022, in Geneva, Switzerland. The Coronavirus impact scale was used to assess the multidimensional impact of the pandemic on children through parent's report. A score higher than one standard deviation above the mean was deemed a severe impact. Parents additionally reported about their offspring HRQoL and mental health with validated scales. Determinants of having been severely impacted were assessed with logistic models, as were the associations between having experienced a severe impact and poor HRQoL or mental health. Results: Out of 2101 participants aged 2–17, 12.7% had experienced a severe pandemic impact. Having a lasting health condition, a pandemic-related worsening of lifestyle habits or an unfavorable family environment were associated with having been severely impacted by the pandemic, while a previous anti-SARS-CoV-2 infection was not. Participants who had experienced a severe pandemic impact were more likely to present poor HRQoL (aOR = 3.1; 95% CI 2.3–4.4) and poor mental health (aOR = 3.9; 95% CI 2.5–6.2). Conclusion: The COVID-19 pandemic may have persistent consequences on the wellbeing of children and adolescents, especially among those with health and family vulnerabilities. [ABSTRACT FROM AUTHOR]

Published
2023
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8. A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents.

Author

Dumont, Roxane, Richard, Viviane, Lorthe, Elsa, Loizeau, Andrea, Pennacchio, Francesco, Zaballa, María-Eugenia, Baysson, Hélène, Nehme, Mayssam, Perrin, Anne, L’Huillier, Arnaud G., Kaiser, Laurent, Barbe, Rémy P., Posfay-Barbe, Klara M., Stringhini, Silvia, Amrein, Deborah, Azman, Andrew S., Bal, Antoine, Balavoine, Michael, Berthelot, Julie, and Bleich, Patrick

Abstract

Post-COVID syndrome remains poorly studied in children and adolescents. Here, we aimed to investigate the prevalence and risk factors of pediatric post-COVID in a population-based sample, stratifying by serological status. Children from the SEROCoV-KIDS cohort study (State of Geneva, Switzerland), aged 6 months to 17 years, were tested for anti-SARS-CoV-2 N antibodies (December 2021-February 2022) and parents filled in a questionnaire on persistent symptoms in their children (lasting over 12 weeks) compatible with post-COVID. Of 1034 children tested, 570 (55.1%) were seropositive. The sex- and age-adjusted prevalence of persistent symptoms among seropositive children was 9.1% (95%CI: 6.7;11.8) and 5.0% (95%CI: 3.0;7.1) among seronegatives, with an adjusted prevalence difference (ΔaPrev) of 4.1% (95%CI: 1.1;7.3). Stratifying per age group, only adolescents displayed a substantial risk of having post-COVID symptoms (ΔaPrev = 8.3%, 95%CI: 3.5;13.5). Identified risk factors for post-COVID syndrome were older age, having a lower socioeconomic status and suffering from chronic health conditions, especially asthma. Our findings show that a significant proportion of seropositive children, particularly adolescents, experienced persistent COVID symptoms. While there is a need for further investigations, growing evidence of pediatric post-COVID urges early screening and primary care management.The post-acute impacts of COVID-19 in children and adolescents are not well understood. In this population-based study in Geneva, the authors find evidence of COVID-19-related symptom persistence beyond 12 weeks in adolescents, and identify chronic conditions and lower socioeconomic status as risk factors. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Epidemiological, virological and serological investigation into a SARS-CoV-2 outbreak (Alpha variant) in a primary school: a prospective longitudinal study

Author

Lorthe, Elsa, primary, Bellon, Mathilde, additional, Michielin, Grégoire, additional, Berthelot, Julie, additional, Zaballa, María-Eugenia, additional, Pennacchio, Francesco, additional, Bekliz, Meriem, additional, Laubscher, Florian, additional, Arefi, Fatemeh, additional, Perez-Saez, Javier, additional, Azman, Andrew S, additional, L’Huillier, Arnaud G, additional, Posfay-Barbe, Klara M, additional, Kaiser, Laurent, additional, Guessous, Idris, additional, Maerkl, Sebastian, additional, Eckerle, Isabella, additional, and Stringhini, Silvia, additional

Published
2021
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10. Epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak (Alpha variant) in a primary school: A prospective longitudinal study.

Author

Lorthe, Elsa, Bellon, Mathilde, Michielin, Grégoire, Berthelot, Julie, Zaballa, María-Eugenia, Pennacchio, Francesco, Bekliz, Meriem, Laubscher, Florian, Arefi, Fatemeh, Perez-Saez, Javier, Azman, Andrew S., L'Huillier, Arnaud G., Posfay-Barbe, Klara M., Kaiser, Laurent, Guessous, Idris, Maerkl, Sebastian J., Eckerle, Isabella, and Stringhini, Silvia

Subjects
SARS-CoV-2, WHOLE genome sequencing, PRIMARY schools, SCHOOL children, ANTIGEN analysis, LONGITUDINAL method, NUCLEOTIDE sequencing
Abstract

Objectives: To report a prospective epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak in a primary school. Methods: As part of a longitudinal, prospective, school-based surveillance study, this investigation involved repeated testing of 73 pupils, 9 teachers, 13 non-teaching staff and 26 household members of participants who tested positive, with rapid antigen tests and/or RT-PCR (Day 0–2 and Day 5–7), serologies on dried capillary blood samples (Day 0–2 and Day 30), contact tracing interviews and SARS-CoV-2 whole genome sequencing. Results: We identified 20 children (aged 4 to 6 years from 4 school classes), 2 teachers and a total of 4 household members who were infected by the Alpha variant during this outbreak. Infection attack rates were between 11.8 and 62.0% among pupils from the 4 school classes, 22.2% among teachers and 0% among non-teaching staff. Secondary attack rate among household members was 15.4%. Symptoms were reported by 63% of infected children, 100% of teachers and 50% of household members. All analysed sequences but one showed 100% identity. Serological tests detected 8 seroconversions unidentified by SARS-CoV-2 virological tests. Conclusions: This study confirmed child-to-child and child-to-adult SARS-CoV-2 transmission and introduction into households. Effective measures to limit transmission in schools have the potential to reduce the overall community circulation. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak (Alpha variant) in a primary school: A prospective longitudinal study

Author

Lorthe, Elsa, Bellon, Mathilde, Michielin, Gregoire, Berthelot, Julie, Zaballa, Maria-Eugenia, Pennacchio, Francesco, Bekliz, Meriem, Laubscher, Florian, Arefi, Fatemeh, Perez-Saez, Javier, Azman, Andrew S., L'Huillier, Arnaud G., Posfay-Barbe, Klara M., Kaiser, Laurent, Guessous, Idris, Maerkl, Sebastian J., Eckerle, Isabella, and Stringhini, Silvia

Subjects
a h1n1 virus, household transmission, elementary-school, county
Abstract

Objectives, To report a prospective epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak in a primary school., Methods, As part of a longitudinal, prospective, school-based surveillance study, this investigation involved repeated testing of 73 pupils, 9 teachers, 13 non-teaching staff and 26 household members of participants who tested positive, with rapid antigen tests and/or RT-PCR (Day 0-2 and Day 5-7), serologies on dried capillary blood samples (Day 0-2 and Day 30), contact tracing interviews and SARS-CoV-2 whole genome sequencing., Results, We identified 20 children (aged 4 to 6 years from 4 school classes), 2 teachers and a total of 4 household members who were infected by the Alpha variant during this outbreak. Infection attack rates were between 11.8 and 62.0% among pupils from the 4 school classes, 22.2% among teachers and 0% among non-teaching staff. Secondary attack rate among household members was 15.4%. Symptoms were reported by 63% of infected children, 100% of teachers and 50% of household members. All analysed sequences but one showed 100% identity. Serological tests detected 8 seroconversions unidentified by SARS-CoV-2 virological tests., Conclusions, This study confirmed child-to-child and child-to-adult SARS-CoV-2 transmission and introduction into households. Effective measures to limit transmission in schools have the potential to reduce the overall community circulation.

12. Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study

Author

Zaballa, María-Eugenia, Perez-Saez, Javier, de Mestral, Carlos, Pullen, Nick, Lamour, Julien, Turelli, Priscilla, Raclot, Charlène, Baysson, Hélène, Pennacchio, Francesco, Villers, Jennifer, Duc, Julien, Richard, Viviane, Dumont, Roxane, Semaani, Claire, Loizeau, Andrea Jutta, Graindorge, Clément, Lorthe, Elsa, Balavoine, Jean-François, Pittet, Didier, Schibler, Manuel, Vuilleumier, Nicolas, Chappuis, François, Kherad, Omar, Azman, Andrew S., Posfay-Barbe, Klara M., Kaiser, Laurent, Trono, Didier, Stringhini, Silvia, Guessous, Idris, Arm-Vernez, Isabelle, Azman, Andrew S, Bachmann, Delphine, Bal, Antoine, Balavoine, Michael, Barbe, Rémy P, Beigbeder, Lison, Berthelot, Julie, Bleich, Patrick, Boehm, Livia, Bryand, Gaëlle, Collombet, Prune, Coudurier-Boeuf, Sophie, Courvoisier, Delphine, Cudet, Alain, Davidovic, Vladimir, D'ippolito, Paola, Dubos, Richard, Eckerle, Isabella, El Merjani, Nacira, Flahault, Antoine, Francioli, Natalie, Frangville, Marion, Harnal, Séverine, Hurst, Samia, Lescuyer, Pierre, L'Huillier, Arnaud G, L'Huissier, François, Martinez, Chantal, Ménard, Lucie, Metral-Boffod, Ludovic, Moulin, Alexandre, Nehme, Mayssam, Noël, Natacha, Posfay-Barbe, Klara M, Poulain, Géraldine, Pugin, Caroline, Rinaldi, Frederic, Rochat, Déborah, Sakvarelidze, Irine, Samir, Khadija, Ramirez, Hugo Santa, Satin, Etienne, Schaller, Philippe, Schrempft, Stephanie, Testini, Stéphanie, Urrutia-Rivas, Déborah, Verolet, Charlotte, Vetter, Pauline, Violot, Guillemette, Wisniak, Ania, and Yerly, Sabine

Subjects
Variants of concern, Omicron, Seroprevalence, Anti-SARS-CoV-2 antibodies, Neutralizing antibodies

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