305 results on '"Bertin B"'
Search Results
2. Appropriate ischemic criteria for type 4a myocardial infarction: insights from the ALPHEUS trial
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Roule, V, primary, Zeitouni, M, additional, Guedeney, P, additional, Beygui, F, additional, El Kasty, M, additional, Braik, N, additional, Bertin, B, additional, Brugier, D, additional, Range, G, additional, Motovska, Z, additional, Cayla, G, additional, Vicaut, E, additional, Montalescot, G, additional, and Silvain, J, additional
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- 2023
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3. Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa.
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Baldeh, Mamadu, Bawa, Flavia K., Bawah, Faiza U., Chamai, Martin, Dzabeng, Francis, Jebreel, Waleed M.A., Kabuya, Jean-Bertin B., Molemodile Dele-Olowu, Shola K., Odoyo, Erick, Rakotomalala Robinson, Dimbintsoa, and Cunnington, Aubrey J.
- Abstract
Point-of-care molecular diagnostics offer solutions to the limited diagnostic availability and accessibility in resource-limited settings. During the COVID-19 pandemic, molecular diagnostics became essential tools for accurate detection and monitoring of SARS-CoV-2. The unprecedented demand for molecular diagnostics presented challenges and catalyzed innovations which may provide lessons for the future selection of point-of-care molecular diagnostics. We searched PubMed from January 2020 to August 2023 to identify lessons learned from the COVID-19 pandemic which may impact the selection of point-of-care molecular diagnostics for future use in sub-Saharan Africa. We evaluated this in the context of REASSURED criteria (Real-time connectivity; Ease of specimen collection; Affordable; Sensitive; Specific; User-friendly; Rapid and robust; Equipment free; and Deliverable to users at the point of need) for point-of-care diagnostics for resource-limited settings. The diagnostic challenges and successes during the COVID-19 pandemic affirmed the importance of the REASSURED criteria but demonstrated that these are not sufficient to ensure new diagnostics will be appropriate for public health emergencies. Capacity for rapid scale-up of diagnostic testing and transferability of assays, data, and technology are also important, resulting in updated REST-ASSURED criteria. Few diagnostics will meet all criteria, and trade-offs between criteria will need to be context-specific. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Lessons from the pandemic: new best practices in selecting molecular diagnostics for point-of-care testing of infectious diseases in sub-Saharan Africa
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Baldeh, Mamadu, primary, Bawa, Flavia K., additional, Bawah, Faiza U., additional, Chamai, Martin, additional, Dzabeng, Francis, additional, Jebreel, Waleed M.A., additional, Kabuya, Jean-Bertin B., additional, Molemodile Dele-Olowu, Shola K., additional, Odoyo, Erick, additional, Rakotomalala Robinson, Dimbintsoa, additional, and Cunnington, Aubrey J., additional
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- 2023
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5. Muscle‐specific, liver‐detargeted adeno‐associated virus gene therapy rescues Pompe phenotype in adult and neonate Gaa−/− mice.
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Sellier, P., Vidal, P., Bertin, B., Gicquel, E., Bertil‐Froidevaux, E., Georger, C., van Wittenberghe, L., Miranda, A., Daniele, N., Richard, I., Gross, D. A., Mingozzi, F., Collaud, F., and Ronzitti, G.
- Abstract
Pompe disease (PD) is a neuromuscular disorder caused by acid α‐glucosidase (GAA) deficiency. Reduced GAA activity leads to pathological glycogen accumulation in cardiac and skeletal muscles responsible for severe heart impairment, respiratory defects, and muscle weakness. Enzyme replacement therapy with recombinant human GAA (rhGAA) is the standard‐of‐care treatment for PD, however, its efficacy is limited due to poor uptake in muscle and the development of an immune response. Multiple clinical trials are ongoing in PD with adeno‐associated virus (AAV) vectors based on liver‐ and muscle‐targeting. Current gene therapy approaches are limited by liver proliferation, poor muscle targeting, and the potential immune response to the hGAA transgene. To generate a treatment tailored to infantile‐onset PD, we took advantage of a novel AAV capsid able to increase skeletal muscle targeting compared to AAV9 while reducing liver overload. When combined with a liver‐muscle tandem promoter (LiMP), and despite the extensive liver‐detargeting, this vector had a limited immune response to the hGAA transgene. This combination of capsid and promoter with improved muscle expression and specificity allowed for glycogen clearance in cardiac and skeletal muscles of Gaa−/− adult mice. In neonate Gaa−/−, complete rescue of glycogen content and muscle strength was observed 6 months after AAV vector injection. Our work highlights the importance of residual liver expression to control the immune response toward a potentially immunogenic transgene expressed in muscle. In conclusion, the demonstration of the efficacy of a muscle‐specific AAV capsid‐promoter combination for the full rescue of PD manifestation in both neonate and adult Gaa−/− provides a potential therapeutic avenue for the infantile‐onset form of this devastating disease. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Nécrolyse épidermique après vaccination contre le COVID-19 : que savons-nous ?
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Ahouach, B., primary, Diaz, E., additional, Bertin, B., additional, Ben Said, B., additional, Combret, S., additional, Grandvuillemin, A., additional, Petitpain, N., additional, Rabier, M.B., additional, Thomas, L., additional, Trenque, T., additional, Oro, S., additional, and Lebrun-Vignes, B., additional
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- 2022
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7. Role of mannose-binding lectin in intestinal homeostasis and fungal elimination
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Choteau, L, Parny, M, François, N, Bertin, B, Fumery, M, Dubuquoy, L, Takahashi, K, Colombel, J-F, Jouault, T, Poulain, D, Sendid, B, and Jawhara, S
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- 2016
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8. Malaria in Refugee Children Resettled to a Holoendemic Area of Sub-Saharan Africa
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Hauser, Manuela, primary, Kabuya, Jean-Bertin B., additional, Mantus, Molly, additional, Kamavu, Luc K., additional, Sichivula, James L., additional, Matende, Wycliffe M., additional, Fritschi, Nora, additional, Shields, Timothy, additional, Curriero, Frank, additional, Kvit, Anton, additional, Chongwe, Gershom, additional, Moss, William J., additional, Ritz, Nicole, additional, and Ippolito, Matthew M., additional
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- 2022
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9. Malaria in Refugee Children Resettled to a Holoendemic Area of Sub-Saharan Africa.
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Hauser, Manuela, Kabuya, Jean-Bertin B, Mantus, Molly, Kamavu, Luc K, Sichivula, James L, Matende, Wycliffe M, Fritschi, Nora, Shields, Timothy, Curriero, Frank, Kvit, Anton, Chongwe, Gershom, Moss, William J, Ritz, Nicole, and Ippolito, Matthew M
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PUBLIC health surveillance , *PSYCHOLOGY of refugees , *EMIGRATION & immigration , *ACQUISITION of data , *REGRESSION analysis , *MALARIA , *SEVERITY of illness index , *MEDICAL records , *MEDICAL referrals , *DESCRIPTIVE statistics , *MALNUTRITION , *RESEARCH funding , *CHILDREN ,MALARIA transmission - Abstract
Background Malaria is a leading cause of morbidity and mortality in refugee children in high-transmission parts of Africa. Characterizing the clinical features of malaria in refugees can inform approaches to reduce its burden. Methods The study was conducted in a high-transmission region of northern Zambia hosting Congolese refugees. We analyzed surveillance data and hospital records of children with severe malaria from refugee and local sites using multivariable regression models and geospatial visualization. Results Malaria prevalence in the refugee settlement was similar to the highest burden areas in the district, consistent with the local ecology and leading to frequent rapid diagnostic test stockouts. We identified 2197 children hospitalized for severe malaria during the refugee crisis in 2017 and 2018. Refugee children referred from a refugee transit center (n = 63) experienced similar in-hospital mortality to local children and presented with less advanced infection. However, refugee children from a permanent refugee settlement (n = 110) had more than double the mortality of local children (P <.001), had lower referral rates, and presented more frequently with advanced infection and malnutrition. Distance from the hospital was an important mediator of the association between refugee status and mortality but did not account for all of the increased risk. Conclusions Malaria outcomes were more favorable in refugee children referred from a highly outfitted refugee transit center than those referred later from a permanent refugee settlement. Refugee children experienced higher in-hospital malaria mortality due in part to delayed presentation and higher rates of malnutrition. Interventions tailored to the refugee context are required to ensure capacity for rapid diagnosis and referral to reduce malaria mortality. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Malaria in Refugee Children Resettled to a Holoendemic Area of Sub-Saharan Africa
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Manuela Hauser, Jean-Bertin B Kabuya, Molly Mantus, Luc K Kamavu, James L Sichivula, Wycliffe M Matende, Nora Fritschi, Timothy Shields, Frank Curriero, Anton Kvit, Gershom Chongwe, William J Moss, Nicole Ritz, and Matthew M Ippolito
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Microbiology (medical) ,Infectious Diseases ,Major Article - Abstract
Background Malaria is a leading cause of morbidity and mortality in refugee children in high-transmission parts of Africa. Characterizing the clinical features of malaria in refugees can inform approaches to reduce its burden. Methods The study was conducted in a high-transmission region of northern Zambia hosting Congolese refugees. We analyzed surveillance data and hospital records of children with severe malaria from refugee and local sites using multivariable regression models and geospatial visualization. Results Malaria prevalence in the refugee settlement was similar to the highest burden areas in the district, consistent with the local ecology and leading to frequent rapid diagnostic test stockouts. We identified 2197 children hospitalized for severe malaria during the refugee crisis in 2017 and 2018. Refugee children referred from a refugee transit center (n = 63) experienced similar in-hospital mortality to local children and presented with less advanced infection. However, refugee children from a permanent refugee settlement (n = 110) had more than double the mortality of local children (P < .001), had lower referral rates, and presented more frequently with advanced infection and malnutrition. Distance from the hospital was an important mediator of the association between refugee status and mortality but did not account for all of the increased risk. Conclusions Malaria outcomes were more favorable in refugee children referred from a highly outfitted refugee transit center than those referred later from a permanent refugee settlement. Refugee children experienced higher in-hospital malaria mortality due in part to delayed presentation and higher rates of malnutrition. Interventions tailored to the refugee context are required to ensure capacity for rapid diagnosis and referral to reduce malaria mortality.
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- 2022
11. Whole Blood Transfusion for Severe Malarial Anemia in a High Plasmodium falciparum Transmission Setting
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Matthew M, Ippolito, Jean-Bertin B, Kabuya, Manuela, Hauser, Luc K, Kamavu, Proscovia Miiye, Banda, Lisa R, Yanek, Rubab, Malik, Modest, Mulenga, Jeffrey A, Bailey, Gershom, Chongwe, Thomas A, Louis, Theresa A, Shapiro, and William J, Moss
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Child, Preschool ,Plasmodium falciparum ,Major Article ,Humans ,Infant ,Anemia ,Blood Transfusion ,Prospective Studies ,Malaria, Falciparum ,Child ,Thrombocytopenia ,Retrospective Studies ,Malaria - Abstract
BACKGROUND: Severe malaria resulting from Plasmodium falciparum infection is the leading parasitic cause of death in children worldwide, and severe malarial anemia (SMA) is the most common clinical presentation. The evidence in support of current blood transfusion guidelines for patients with SMA is limited. METHODS: We conducted a retrospective cohort study of 911 hospitalized children with SMA in a holoendemic region of Zambia to examine the association of whole blood transfusion with in-hospital survival. Data were analyzed in adjusted logistic regression models using multiple imputation for missing data. RESULTS: The median age of patients was 24 months (interquartile range, 16–30) and overall case fatality was 16%. Blood transfusion was associated with 35% reduced odds of death in children with SMA (odds ratio, 0.65; 95% confidence interval, .52–.81; P = .0002) corresponding to a number-needed-to-treat (NNT) of 14 patients. Children with SMA complicated by thrombocytopenia were more likely to benefit from transfusion than those without thrombocytopenia (NNT = 5). Longer storage time of whole blood was negatively associated with survival and with the posttransfusion rise in the platelet count but was not associated with the posttransfusion change in hemoglobin concentration. CONCLUSIONS: Whole blood given to pediatric patients with SMA was associated with improved survival, mainly among those with thrombocytopenia who received whole blood stored for
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- 2021
12. Whole Blood Transfusion for Severe Malarial Anemia in a High Plasmodium falciparum Transmission Setting.
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Ippolito, Matthew M, Kabuya, Jean-Bertin B, Hauser, Manuela, Kamavu, Luc K, Banda, Proscovia Miiye, Yanek, Lisa R, Malik, Rubab, Mulenga, Modest, Bailey, Jeffrey A, Chongwe, Gershom, Louis, Thomas A, Shapiro, Theresa A, Moss, William J, and Research, for the Southern and Central Africa International Centers of Excellence for Malaria
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ANEMIA treatment , *CONFIDENCE intervals , *BLOOD transfusion , *MORTALITY , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *THROMBOCYTOPENIA , *ODDS ratio , *LOGISTIC regression analysis , *LONGITUDINAL method , *HOSPITAL care of children ,MALARIA transmission - Abstract
Background Severe malaria resulting from Plasmodium falciparum infection is the leading parasitic cause of death in children worldwide, and severe malarial anemia (SMA) is the most common clinical presentation. The evidence in support of current blood transfusion guidelines for patients with SMA is limited. Methods We conducted a retrospective cohort study of 911 hospitalized children with SMA in a holoendemic region of Zambia to examine the association of whole blood transfusion with in-hospital survival. Data were analyzed in adjusted logistic regression models using multiple imputation for missing data. Results The median age of patients was 24 months (interquartile range, 16–30) and overall case fatality was 16%. Blood transfusion was associated with 35% reduced odds of death in children with SMA (odds ratio, 0.65; 95% confidence interval,.52–.81; P =.0002) corresponding to a number-needed-to-treat (NNT) of 14 patients. Children with SMA complicated by thrombocytopenia were more likely to benefit from transfusion than those without thrombocytopenia (NNT = 5). Longer storage time of whole blood was negatively associated with survival and with the posttransfusion rise in the platelet count but was not associated with the posttransfusion change in hemoglobin concentration. Conclusions Whole blood given to pediatric patients with SMA was associated with improved survival, mainly among those with thrombocytopenia who received whole blood stored for <4 weeks. These findings point to a potential use for incorporating thrombocytopenia into clinical decision making and management of severe malaria, which can be further assessed in prospective studies, and underline the importance of maintaining reliable blood donation networks in areas of high malaria transmission. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Intérêt des examens cliniques objectifs et structurés (ECOS) dans la formation initiale des nouveaux répondeurs au centre antipoison de Lyon, une étude pilote
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Facile, A., Benkhedimallah, A., Nguyen, K., Grenet, G., Bertin, B., Pizzoglio, V., Patat, A.-M., Paret, N., and Auffret, M.
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- 2023
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14. A polarized nucleus-cytoskeleton-ECM connection controls collective migration and cardioblasts number inDrosophila
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Dondi, C, primary, Bertin, B, additional, Da Ponte, JP, additional, Wojtowicz, I, additional, Jagla, K, additional, and Junion, G, additional
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- 2019
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15. P3124Predictive value of the residual SYNTAX score following primary PCI in multivessel patients with MI-related cardiogenic shock - a CULPRIT SHOCK sub-analysis
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Barthelemy, O, primary, Rouanet, S, additional, Brugier, D, additional, Vignoles, N, additional, Bertin, B, additional, Zeitouni, M, additional, Guedeney, P, additional, Overtchouk, P, additional, Hage, G, additional, Hauguel-Moreau, M, additional, Akin, I, additional, Desch, S, additional, Vicaut, E, additional, Thiele, H, additional, and Montalescot, G, additional
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- 2019
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16. Peroxisome proliferator-activated receptor gamma (PPAR gamma) regulates lactase expression and activity in the gut
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Fumery, M. (Mathurin), Speca, S. (Silvia), Langlois, A. (Audrey), Davila, A-M. (Anne-Marie), Dubuquoy, C. (Caroline), Grauso, M. (Marta), Martin Mena, A. (Anthony), Figeac, M. (Martin), Metzger, D. (Daniel), Rousseaux, C. (Christel), Colombel, J-F. (Jean-Frederic), Dubuquoy, L. (Laurent), Desreumaux, P. (Pierre), Bertin, B. (Benjamin), Inserm, Université de Lille, CHU Lille, Lille Inflammation Research International Center - U 995 [LIRIC], Université Paris-Saclay, Physiopathologie des Maladies Inflammatoires de l'Intestin, Université Paris Saclay (COmUE), Plateforme de génomique fonctionnelle et structurelle [Lille], Institut de Génétique et de Biologie Moléculaire et Cellulaire [IGBMC], and Icahn School of Medicine at Mount Sinai [New York] [MSSM]
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lactose intolerance ,intestinal epithelial cells ,hypolactasia ,PPARgamma ,lactase - Abstract
ReportPeroxisome proliferator-activated receptor gamma(PPARc) regulates lactase expression and activity inthe gutMathurin Fumery1,2,3,†, Silvia Speca1,2,†, Audrey Langlois1,2, Anne-Marie Davila4, Caroline Dubuquoy5,Marta Grauso4, Anthony Martin Mena1,2, Martin Figeac6, Daniel Metzger7, Christel Rousseaux5,Jean-Frederic Colombel8, Laurent Dubuquoy1,2, Pierre Desreumaux1,2,9& Benjamin Bertin1,2,*Abstract 9
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- 2017
17. IN VITRO CULTURE OF TESTICULAR SPERMATOZOA AN IMPROVEMENT FOR THE ICSI OUTCOME?: OC-15-133
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Nijs, M., Scgal-Bertin, B., Vandammc, B., Vanderzwalmen, P., Lejeune, B., and Schoysman, R.
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- 1997
18. Limites des contrôles de qualité des analyseurs de gaz du sang pour la validité des tests d’hyperoxie
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Bertin, B., primary, Turquier, S., additional, Chardon, L., additional, and Glérant, J.C., additional
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- 2018
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19. Physical and mechanical properties of Ayous wood (Triplochiton scleroxylon) from Cameroon
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Bertin Biekop, Paul William, Mejouyo Huisken, Didier Fokwa, and Ebenezer Njeugna
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Forestry ,SD1-669.5 ,Environmental sciences ,GE1-350 - Abstract
The present study deals with Ayous wood from the East Cameroon forest reserve in the locality of Abong-Mbang. The water absorption rate of Ayous wood and the absorption kinetics were evaluated. Ayous wood reached its absorption saturation around 28 days. The primary diffusion coefficient was found to be 1.51 x 10-11 m2/s with a standard deviation of 0.23x10-11 m2/s while the saturation absorption rate is 144% with a standard deviation of 16.3%. About the modeling of kinetic absorption, many models were tested, and (Sikame, 2014) was the best model for our experiments. In order to determine the mechanical properties, four point bending and compression test were done through the three orthotropic directions. It is found that the modulus of elasticity value is 8792.75 MPa with a standard deviation of 527 MPa and the fracture stress (σl) value is 53.6 MPa with a standard deviation of 8 MPa. Longitudinal, radial and tangential compressive stress are 31.51 MPa, 29.15 MPa and 31.4 MPa respectively, with standard deviations of 4.34MPa, 4.52 MPa and 4.23 MPa.
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- 2023
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20. Research Article (New England Journal of Medicine) Four artemisinin-based treatments in African pregnant women with malaria
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Pekyi, Divine, Ampromfi, Akua A., Tinto, Halidou, Traoré-Coulibaly, Maminata, Tahita, Marc C., Valéa, Innocent, Mwapasa, Victor, Kalilani-Phiri, Linda, Kalanda, Gertrude, Madanitsa, Mwayiwawo, Ravinetto, Raffaella, Mutabingwa, Theonest, Gbekor, Prosper, Tagbor, Harry, Antwi, Gifty, Menten, Joris, De Crop, Maaike, Claeys, Yves, Schurmans, Celine, Van Overmeir, Chantal, Thriemer, Kamala, Van Geertruyden, Jean-Pierre, D’Alessandro, Umberto, Nambozi, Michael, Mulenga, Modest, Hachizovu, Sebastian, Kabuya, Jean-Bertin B., and Mulenga, Joyce
- Abstract
Background: Information regarding the safety and efficacy of artemisinin combination treatments for malaria in pregnant women is limited, particularly among women who live in sub-Saharan Africa.Methods: We conducted a multicenter, randomized, open-label trial of treatments for malaria in pregnant women in four African countries. A total of 3428 pregnant women in the second or third trimester who had falciparum malaria (at any parasite density and regardless of symptoms) were treated with artemether–lumefantrine, amodiaquine–artesunate, mefloquine–artesunate, or dihydroartemisinin– piperaquine. The primary end points were the polymerase-chain-reaction (PCR)–adjusted cure rates (i.e., cure of the original infection; new infections during follow-up were not considered to be treatment failures) at day 63 and safety outcomes.Results: The PCR-adjusted cure rates in the per-protocol analysis were 94.8% in the artemether–lumefantrine group, 98.5% in the amodiaquine– artesunate group, 99.2% in the dihydroartemisinin–piperaquine group, and 96.8% in the mefloquine–artesunate group; the PCR-adjusted cure rates in the intention-to-treat analysis were 94.2%, 96.9%, 98.0%, and 95.5%, respectively. There was no significant difference among the amodiaquine–artesunate group, dihydroartemisinin–piperaquine group, and the mefloquine–artesunate group. The cure rate in the artemether–lumefantrine group was significantly lower than that in the other three groups, although the absolute difference was within the 5-percentage-point margin for equivalence. The unadjusted cure rates, used as a measure of the post-treatment prophylactic effect, were significantly lower in the artemether–lumefantrine group (52.5%) than in groups that received amodiaquine–artesunate (82.3%), dihydroartemisinin–piperaquine (86.9%), or mefloquine–artesunate (73.8%). No significant difference in the rate of serious adverse events and in birth outcomes was found among the treatment groups. Drug-related adverse events such as asthenia, poor appetite, dizziness, nausea, and vomiting occurred significantly more frequently in the mefloquine–artesunate group (50.6%) and the amodiaquine–artesunate group (48.5%) than in the dihydroartemisinin–piperaquine group (20.6%) and the artemether–lumefantrine group (11.5%) (P
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- 2016
21. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction
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Bonaca, MP, Bhatt, DL, Cohen, M, Steg, PG, Storey, RF, Jensen, EC, Magnani, G, Bansilal, S, Fish, MP, Im, K, Bengtsson, O, Ophuis, TO, Budaj, A, Theroux, P, Ruda, M, Hamm, C, Goto, S, Spinar, J, Nicolau, JC, Kiss, RG, Murphy, SA, Wiviott, SD, Held, P, Braunwald, E, Sabatine, MS, Morin, S, Dantzer, E, Acquilano, D, McGuire, RL, Gannon, JB, Gershman, E, Ahlbom, AM, Boberg, B, Abola, MT, Ardissino, D, Aylward, P, Corbalan, R, Dalby, A, Diaz, R, Hu, DY, Isaza, D, Kamensky, G, Kiss, R, Kontny, F, Lopez-Sendon, J, Medina, F, Montalescot, G, Nicolau, J, Paolasso, E, Parkhomenko, A, Van De Werf, F, Anderson, JL, White, HD, Verheugt, FWA, Pedersen, TR, DeMets, DL, Lowe, C, Arevalo, C, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Alvarisqueta, A, De Gennaro, N, Berli, M, Roude, AE, Di Gennaro, JA, Albisu, JF, Caccavo, A, Torres, M, Cuadrado, J, Bordoni, P, Cuello, J, Aviles, A, Glenny, A, Recoaro, R, Fernandez, R, Strada, BN, Fuentealba, V, Gallo, C, Duran, RG, Garcia, C, Hominal, M, Castoldi, M, Jure, H, Pacora, FF, Lorenzatti, A, Martinez, JM, Macin, S, Cocco, N, MacKinnon, I, Bagnato, MB, Marino, J, Cusimano, S, Arias, V, Focaccia, M, Muntaner, J, Mansilla, V, Poy, C, Prado, A, Paterlini, G, Montana, O, Camino, A, Sala, J, Luciani, C, Vico, M, Morell, Y, Dumont, C, Vottero, E, Zangroniz, P, Lescano, A, Morara, P, Marquez, LL, Patron, FR, Labarta, GB, Sivila, CD, Quiroga, AR, Maffei, L, Sassone, S, Rolandi, F, Vesentini, N, Carnero, G, Del Verme, S, Hershson, A, Figal, JC, Viso, ME, Hii, C, Smith, K, Singh, B, Acampo, M, Rogers, J, ODonoghue, M, Amerena, J, Long, A, Dart, A, Kay, S, Worthley, M, Nimmo, J, Lehman, R, Morrison, H, Dick, R, Savage, C, van Gaal, W, Park, M, Blombery, P, McCarthy, C, Oqueli, E, Hill, D, Sader, M, Vrachas, D, Purnell, P, Vibert, J, Collins, N, Gordon, A, Arstall, M, Rose, J, Aroney, C, Cleave, P, Fitzpatrick, M, Mackenzie, M, Garrahy, P, Hall, C, Nelson, G, Reid, E, Lee, A, Gibbs, J, Thompson, P, Crittenden, J, Hammett, C, Hindom, L, Antonis, P, Manzoney, A, Cross, D, Pollard, C, Brieger, D, Wu, J, Whelan, A, Tulloch, G, Taylor, A, Smith, B, Horowitz, J, Black, M, Boland, J, Malmendier, D, Celen, H, Wendelen, E, Claeys, M, Pieter, M, Cools, F, Simons, N, De Maeseneire, S, De Wolf, L, Brike, C, Dubois, P, Bolado, ACY, Foading-Deffo, B, Tahon, S, Friart, A, Arend, C, Gevaert, S, Verdegem, P, Marechal, P, Gits, F, Pierard, L, Celentano, C, Pirenne, B, Bouvy, C, Renkin, J, Huyberechts, D, Sinnaeve, P, De Velder, L, Stammen, F, Casier, T, Striekwold, H, Van den Broeck, D, Thoeng, J, Goris, R, Timmermans, P, Collard, SJ, Van De Borne, P, De Clippel, M, Wollaert, B, Jacobs, C, Vankelecom, B, Daelemans, Y, Vervoort, G, Drieghe, S, Vranckx, P, Janssen, A, Vrolix, M, Simenon, I, Wijns, W, Delacroix, H, Denie, D, Schoors, D, Lemoine, I, Cornelis, K, Willems, AM, Schroder, E, Domange, J, Greque, G, Machado, H, Armaganijan, D, Del Monaco, MI, da Silva, D, Nakazone, R, Dutra, O, Vaz, R, Daher, R, Rodrigues, D, Guimaraes, A, Teixeira, A, Saraiva, J, Leaes, P, Blacher, M, Maia, L, Nakazone, MA, Manenti, E, Ruschel, K, Marin-Neto, J, Pavao, R, Preto, R, Junior, AA, Oliveira, G, Rassi, S, Sampaio, D, Rossi, PR, dos Santos, L, de Souza, J, Lino, E, Filho, PP, Zucchetti, C, Gomes, M, de Paiva, A, Sousa, AC, Almeida, A, Botelho, R, da Silva, R, Giraldez, R, Franken, M, Faludi, A, Bertolami, M, Hernandes, M, Lucas, N, Carvalho, A, Bertolami, A, Precoma, D, Geralde, L, Pereira, A, Cesar, L, Mioto, B, Marino, R, Rabelo, W, dos Santos, F, Vidotti, M, Mangione, J, Mauro, M, Kormann, A, Ultramari, F, Zimmermann, S, Michalaros, Y, Fonseca, M, Sampaio, C, Eliaschewitz, F, Barbosa, E, Drews, C, de Lorenzo, A, Barros, C, Cancado, G, Neuesnchwander, F, Zimmermann, E, Chompalova, B, Denchev, S, Gocheva, N, Mihov, A, Mincheva, V, Gelev, V, Tisheva, S, Todorov, G, Goudev, A, Parvanova, Z, Todorova, M, Mitkova, M, Smilov, L, Yakovova, 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Rekovets, O, Kraiz, I, Kamenska, E, Tseluyko, V, Yakovleva, L, Yena, L, Artemenko, V, Koval, O, Kaplan, P, Karpenko, O, Nevolina, I, Bazilevych, A, Harbar, M, Rudenko, L, Beregova, O, Mostovyi, Y, Rasputina, L, Vatutin, M, Shevelok, A, Kovalenko, V, Polenova, N, Amosova, K, Tkachenko, L, Volkov, V, Zaprovalna, O, Storey, R, Thomas, M, Pell, A, Moriarty, A, Kinnin, M, Ahsan, A, Burton, J, ORourke, B, Young, J, Lang, C, Forbes, J, Rowlands, D, Hamill, S, Sprigings, D, Cadd, A, de Belder, M, Atkinson, B, Ramsey, M, Fagan, JC, Pye, M, Wright, L, Keeling, P, Hughes, D, Fraser, D, Phillips, H, Muthusamy, R, Lawan, M, Levy, T, Kennard, S, Bodalia, B, Mottram, J, Calvert, J, Brodie, K, Gunstone, A, Douglas, C, Trouton, T, Hunter, B, Gerber, R, Pepper, H, Mathur, A, Andiapen, M, Baumbach, A, Bowles, R, Hildick-Smith, D, McGregor, A, Loh, I, Plocky, J, Adams, K, Clemmer, K, Aggarwal, K, Burkhardt, V, Costa, M, Lemmertz, K, Anderson, J, York, T, Angiolillo, D, Green, E, Sperling, M, Vasquez, E, Aycock, G, Tatum, D, Amin, J, Davidson, A, Hendrix, E, Shepard, L, Strain, J, Michel, K, Talano, J, Szalanski, N, Berk, M, Ibarra, M, Bhagwat, R, Winterrowd, D, Bilazarian, S, Marsters, M, Blonder, R, Graf, L, Brilakis, E, Roesle, M, Byrd, L, Sullivan, A, Longo, J, Pennella, A, Westerhausen, D, Weil, R, Carr, K, Piazza, J, Carr, KW, Castello, R, Hawks, M, Chandna, H, Holly, D, Chandrashekhar, YS, Molinaro, N, Carter, M, Antonino, M, Kosmicki, D, Kelley, M, Richwine, R, Pazier, P, Glasgow, B, Bresee, S, Alexander, J, Concha, M, Martinez, E, Connelly, T, Schenks, R, Cooper, M, Garman, V, Condit, J, White, A, Fialkow, J, Mckercher, M, Luna, M, Soto, G, Prodafikas, J, Rambaud, B, Donovan, J, Mudd, D, Doty, W, Parsons, T, D'Urso, M, Bies, J, Han, J, Treadwell, M, Erickson, B, Dahl, P, Fattal, P, Braem, J, Felten, W, Prior, J, French, W, Barillas, O, Berger, R, Genova, E, Gelernt, M, Cockrell, D, Miller, G, Dumka, K, Gill, S, Elliot, S, Goldberg, R, Barrett, M, Gordon, P, Stern, L, Ayres, T, Rhule, V, Gupta, D, Holton, T, Haddad, T, Jain, J, Hakas, J, McSorley, J, Hamroff, G, Hollenweger, L, Wainwright, W, Jones, S, Casagrande, M, Casagrande, MG, Effat, M, Mardis, R, Henderson, D, Millard, D, Hermany, P, Meissner-Dengler, S, Hinchman, D, Luck, K, Hodson, R, Severson, L, Horwitz, P, Miller, K, Isserman, S, Moore, C, Jan, M, Bilyk, O, Kersh, R, DaCosta, A, Kim, E, Gonzales, C, Kmetzo, J, Taylor, D, Knutson, T, Belanger, B, Hage-Korban, E, Harrington, A, Murdock, D, Heiman, M, Dandekar, U, Khan, M, Khan, G, Lui, H, Holman, L, MacDonald, L, Derbyshire, S, Watkins, K, Mayer, N, Mitchell, B, McCullum, K, Delio-Cox, B, Mckay, R, Cloutier, J, McKenzie, M, Rodkey, K, McLaurin, B, Lack, A, Minisi, A, Jeter, D, Mitchell, R, Keane-Richmond, P, Stine, R, Bullivant, M, Morford, R, White, J, Oberoi, M, Geraldo-Abache, A, O'Dea, D, Mehta, R, Tang, N, Ong, S, Edwards, M, Osborne, J, Alonzo, C, Lev, V, Monroe, J, Popeil, L, Sorrentino, N, Portelli, J, Landi, T, Potu, R, Smith, N, Prashad, R, McDonough, C, Qureshi, M, Howe, A, Raikhel, M, Arsate, M, Rogers, W, Saag, L, Sangrigoli, R, Schwarz, L, Abu-Fadel, M, Hagee, A, Kinnaman, S, McDaniel, V, Wilson, V, Purcell, T, Roberts, J, Riofrio, K, Shah, U, Narang, S, Gredler, F, Knap, P, Shanes, J, Hansen, C, Sharma, M, Gibson, T, Sheldon, W, Bohn, A, Siegel, C, Tibbits, L, Singh, V, Nelson, M, Singh, N, Logwood, D, Randhawa, P, Vargas, B, Stegemoller, R, Cole, B, Aggarwal, R, Johnson, M, Steinhoff, J, Dunaway, B, Patel, K, Boomer, L, Taheri, H, Morgan, K, Tahirkheli, N, Santos, A, Thadani, U, Alexander, D, Bennett, W, Kelley, E, Thomas, J, Macnicholas, D, Varma, S, Evans, S, Vlastaris, A, Bittel, B, Voyce, S, Mack, B, Weiss, R, Fournier, T, Whitney, R, Orosco, C, Willis, J, VonGerichten, S, Wiseman, A, Sharrow, A, Wohns, D, Schuitema, J, Amin, M, Ramus, A, Wilson, W, Moeller, C, Newell, M, Tindell, L, Rivera, W, Kwierant, J, Bretton, E, Corbin, B, Labroo, A, Lopez, C, Brown, C, Craig, M, Lucca, M, Keinanen, T, Eisenberg, S, Fielding, M, Doorey, A, Squire, A, Suresh, D, Frost, J, Teklinski, A, Stone, B, Waksman, R, Griffin, S, Wharton, W, Blakely, J, Fishbein, G, Weller, C, Camp, A, Fisher, S, Meholick, A, Hejna, E, Anderson, R, Long, S, Parikh, S, Norton, N, Vijay, N, Washam, M, Smith, S, and Stepanov, N
- Abstract
BACKGROUND The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial infarction has not been established. We investigated the efficacy and safety of ticagrelor, a P2Y(12) receptor antagonist with established efficacy after an acute coronary syndrome, in this context. METHODS We randomly assigned, in a double-blind 1: 1: 1 fashion, 21,162 patients who had had a myocardial infarction 1 to 3 years earlier to ticagrelor at a dose of 90 mg twice daily, ticagrelor at a dose of 60 mg twice daily, or placebo. All the patients were to receive low-dose aspirin and were followed for a median of 33 months. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The primary safety end point was Thrombolysis in Myocardial Infarction (TIMI) major bleeding. RESULTS The two ticagrelor doses each reduced, as compared with placebo, the rate of the primary efficacy end point, with Kaplan-Meier rates at 3 years of 7.85% in the group that received 90 mg of ticagrelor twice daily, 7.77% in the group that received 60 mg of ticagrelor twice daily, and 9.04% in the placebo group (hazard ratio for 90 mg of ticagrelor vs. placebo, 0.85; 95% confidence interval [CI], 0.75 to 0.96; P = 0.008; hazard ratio for 60 mg of ticagrelor vs. placebo, 0.84; 95% CI, 0.74 to 0.95; P = 0.004). Rates of TIMI major bleeding were higher with ticagrelor (2.60% with 90 mg and 2.30% with 60 mg) than with placebo (1.06%) (P < 0.001 for each dose vs. placebo); the rates of intracranial hemorrhage or fatal bleeding in the three groups were 0.63%, 0.71%, and 0.60%, respectively. CONCLUSIONS In patients with a myocardial infarction more than 1 year previously, treatment with ticagrelor significantly reduced the risk of cardiovascular death, myocardial infarction, or stroke and increased the risk of major bleeding. (Funded by AstraZeneca; PEGASUS-TIMI 54 ClinicalTrials.gov number, NCT01225562.)
- Published
- 2015
22. Dissecting the role of PPARgamma in intestinal fibrosis: EMT-activator ZEB1 as new molecular target
- Author
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Speca, S, Flati, Vincenzo, Dubuquoy, C, Rousseaux, C, Langlois, A, Dubuquoy, L, Bertin, B, Bellinvia, S, Desreumaux, P, and Latella, Giovanni
- Subjects
TGFbeta ,intestinal fibrosis ,Zinc finger E-box-binding homeobox 1 (ZEB1) - Published
- 2014
23. Correlation between binding activity, inhibition of lymphoblastic transformation and metabolism of tixocortol 21 pivalate in mouse thymocytes
- Author
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Lelièvre, V., Bertin, B., Chanoine, F., Buré, J., and Junien, J. L.
- Published
- 1987
- Full Text
- View/download PDF
24. PPAR-gamma improves intestinal fibrosis by targeting the EMT-activator ZEB1
- Author
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Speca, S, Flati, Vincenzo, Dubuquoy, C, Rousseaux, C, Langlois, A, Dubuquoy, L, Bertin, B, Bellinvia, S, Desreumaux, P, and Latella, Giovanni
- Published
- 2013
25. Ged-0507-34 levo, a novel modulator of PPAR gammaas new terapeutic strategy in the treatment of intestinal fibrosis
- Author
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Speca, Rousseaux, C, Dubuquoy, C, Vetuschi, Antonella, Sferra, Roberta, Bertin, B, Dubuquoy, L, Gaudio, E, Bellinvia, S, Desreumaux, P, and Latella, Giovanni
- Published
- 2012
26. Regulation of DNA methylation patterns by ck2-mediated phosphorylation of dnmt3a
- Author
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Deplus, R., Blanchon, L., Rajavelu, A., Boukaba, A., Defrance, M., Luciani, J., Rothe, F., Dedeurwaerder, S., Denis, H., Brinkman, A.B., Simmer, F., Muller, F., Bertin, B., Berdasco, M., Putmans, P., Calonne, E., Litchfield, D.W., Launoit, Y. de, Jurkowski, T.P., Stunnenberg, H.G., Bock, C., Sotiriou, C., Fraga, M.F., Esteller, M., Jeltsch, A., Fuks, F., Deplus, R., Blanchon, L., Rajavelu, A., Boukaba, A., Defrance, M., Luciani, J., Rothe, F., Dedeurwaerder, S., Denis, H., Brinkman, A.B., Simmer, F., Muller, F., Bertin, B., Berdasco, M., Putmans, P., Calonne, E., Litchfield, D.W., Launoit, Y. de, Jurkowski, T.P., Stunnenberg, H.G., Bock, C., Sotiriou, C., Fraga, M.F., Esteller, M., Jeltsch, A., and Fuks, F.
- Abstract
Contains fulltext : 131557.pdf (publisher's version ) (Open Access)
- Published
- 2014
27. Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits
- Author
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Richard M. Breyer, Bertin B, W Schütz, Arthur Donny Strosberg, Michael Freissmuth, and Stefano Marullo
- Subjects
Agonist ,G protein ,medicine.drug_class ,Alpha (ethology) ,Cell Biology ,Biology ,medicine.disease_cause ,Biochemistry ,Molecular biology ,Adenylyl cyclase ,chemistry.chemical_compound ,nervous system ,chemistry ,medicine ,Signal transduction ,Receptor ,Molecular Biology ,Escherichia coli ,G alpha subunit - Abstract
Signaling through serotonin 5-HT1A receptors involves multiple pathways. We have investigated the functional coupling of the human 5-HT1A receptor to different G proteins using an in vitro reconstitution system based on the expression of recombinant receptor (r5-HT1A) and G alpha-subunits (rG alpha) in Escherichia coli. The r5-HT1A receptor was expressed by insertion in a vector allowing its active expression in E. coli inner membranes. Binding of the selective agonist [3H] +/- 8-hydroxy-(2-N-dipropylamine)tetralin ([3H]8-OH-DPAT) to intact bacteria or E. coli membranes was saturable with a KD of approximately 8 nM and an average of 120 sites/bacterium. Binding properties of several serotoninergic ligands to r5-HT1A receptors were comparable with those measured in mammalian cells. Incubation of rG alpha.beta gamma with E. coli membranes resulted in high affinity agonist [3H]8-OH-DPAT binding (KD = 0.7 nM) and titration with a panel of rG alpha subtypes showed the order of potency: rGi alpha-3 greater than rGi alpha-2 greater than rGi alpha-1 much greater than rGo alpha, while rGs alpha appeared incapable of interacting with 5-HT1A receptors. Moreover, agonist-mediated enhancement of [35S]guanosine 5'-O-(3-thiotriphosphate) binding to rGi alpha confirmed the achievement of the functional interaction between receptor and G proteins. Our findings are in agreement with the in vivo ability of 5-HT1A receptors to activate Gi alpha related to adenylyl cyclase inhibition or K+ channel activation, but do not support previously reported adenylyl cyclase stimulation through interaction with Gs alpha.
- Published
- 1992
28. New insight into dexamethasone activity in lymphoblast transformation of mouse thymocytes
- Author
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Bertin, B., Buré, J., Junien, J. L., and Levièvre, V.
- Published
- 1986
- Full Text
- View/download PDF
29. P084 Dissecting the role of PPARgamma in intestinal fibrosis: EMT-activator ZEB1 as new molecular target
- Author
-
Speca, S., primary, Flati, V., additional, Rousseaux, C., additional, Dubuquoy, C., additional, Langlois, A., additional, Dubuquoy, L., additional, Bertin, B., additional, Bellinvia, S., additional, Desreumaux, P., additional, and Latella, G., additional
- Published
- 2014
- Full Text
- View/download PDF
30. Purification and identification of two putative autolytic sites in human calpain 3 (p94) expressed in heterologous systems
- Author
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Luc Camoin, J L Guillaume, Maurice Hattab, Federici C, Jacques S. Beckmann, Yuval Eshdat, Arthur Donny Strosberg, Bertin B, and Isabelle Richard
- Subjects
Blotting, Western ,Molecular Sequence Data ,Biophysics ,Heterologous ,Muscle Proteins ,Sf9 ,Biology ,Spodoptera ,medicine.disease_cause ,Transfection ,Biochemistry ,Antibodies ,Chromatography, Affinity ,law.invention ,Cell Line ,Western blot ,Affinity chromatography ,law ,Nickel ,medicine ,Animals ,Humans ,Amino Acid Sequence ,Muscle, Skeletal ,Molecular Biology ,Escherichia coli ,medicine.diagnostic_test ,Calpain ,Molecular biology ,Peptide Fragments ,Recombinant Proteins ,Rats ,Isoenzymes ,Polyclonal antibodies ,Recombinant DNA ,biology.protein ,Electrophoresis, Polyacrylamide Gel - Abstract
Human muscle-specific calpain (CAPN3) was expressed in two heterologous systems: Sf9 insect cells and Escherichia coli cells. Polyclonal antibodies were prepared against peptides whose sequences were taken from the three unique regions of human CAPN3, namely NS, IS1, and IS2, which are not found in other members of the calpain family. Western blot analysis using these antibodies revealed that CAPN3 was well expressed in both systems. However, considerable rapid degradation of the expressed CAPN3 was observed in both Sf9 and E. coli cells. These antibodies were therefore also used to detect CAPN3 and its degradation products in human and rat muscles, as well as to detect the protein throughout the purification of the recombinant His-tagged human CAPN3 by Ni 2+ affinity chromatography and by immunopurification over immobilized antibody. An alternative purification procedure was used for purification of all putative CAPN3 immunoreactive fragments by combining SDS–PAGE and hydroxyapatite chromatography. Two fragments of CAPN3 of approximately 55 kDa were purified, and their N-terminal amino acid sequencing demonstrated that cleavage of CANP3 occurred between residues 30–31 and 412–413, thus providing the first evidence for the localization of putative autolytic sites in this enzyme.
- Published
- 1999
31. P056 GED-0507–34 Levo, a novel modulator of PPARgamma as new therapeutic strategy in the treatment of intestinal fibrosis
- Author
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Speca, S., primary, Rousseaux, C., additional, Dubuquoy, C., additional, Vetuschi, A., additional, Sferra, R., additional, Bertin, B., additional, Dubuquoy, L., additional, Gaudio, E., additional, Bellinvia, S., additional, Desreumaux, P., additional, and Latella, G., additional
- Published
- 2013
- Full Text
- View/download PDF
32. P059 Cigarette smoke improves colonic inflammation through NKT cells activation in mice
- Author
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Montbarbon, M., primary, Pichavant, M., additional, Langlois, A., additional, Erdual, E., additional, Dharancy, S., additional, Dubuquoy, L., additional, Trottein, F., additional, Desreumaux, P., additional, Gosset, P., additional, and Bertin, B., additional
- Published
- 2012
- Full Text
- View/download PDF
33. Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits
- Author
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Bertin B, Michael Freissmuth, Rm, Breyer, Schütz W, Ad, Strosberg, and Marullo S
- Subjects
8-Hydroxy-2-(di-n-propylamino)tetralin ,Tetrahydronaphthalenes ,Molecular Sequence Data ,Gene Expression ,Ligands ,Binding, Competitive ,Recombinant Proteins ,GTP-Binding Proteins ,Guanosine 5'-O-(3-Thiotriphosphate) ,Receptors, Serotonin ,Escherichia coli ,Humans ,Electrophoresis, Polyacrylamide Gel ,Amino Acid Sequence ,Plasmids ,Signal Transduction - Abstract
Signaling through serotonin 5-HT1A receptors involves multiple pathways. We have investigated the functional coupling of the human 5-HT1A receptor to different G proteins using an in vitro reconstitution system based on the expression of recombinant receptor (r5-HT1A) and G alpha-subunits (rG alpha) in Escherichia coli. The r5-HT1A receptor was expressed by insertion in a vector allowing its active expression in E. coli inner membranes. Binding of the selective agonist [3H] +/- 8-hydroxy-(2-N-dipropylamine)tetralin ([3H]8-OH-DPAT) to intact bacteria or E. coli membranes was saturable with a KD of approximately 8 nM and an average of 120 sites/bacterium. Binding properties of several serotoninergic ligands to r5-HT1A receptors were comparable with those measured in mammalian cells. Incubation of rG alpha.beta gamma with E. coli membranes resulted in high affinity agonist [3H]8-OH-DPAT binding (KD = 0.7 nM) and titration with a panel of rG alpha subtypes showed the order of potency: rGi alpha-3 greater than rGi alpha-2 greater than rGi alpha-1 much greater than rGo alpha, while rGs alpha appeared incapable of interacting with 5-HT1A receptors. Moreover, agonist-mediated enhancement of [35S]guanosine 5'-O-(3-thiotriphosphate) binding to rGi alpha confirmed the achievement of the functional interaction between receptor and G proteins. Our findings are in agreement with the in vivo ability of 5-HT1A receptors to activate Gi alpha related to adenylyl cyclase inhibition or K+ channel activation, but do not support previously reported adenylyl cyclase stimulation through interaction with Gs alpha.
- Published
- 1992
34. A conserved retinoid X receptor (RXR) from the mollusk Biomphalaria glabrata transactivates transcription in the presence of retinoids
- Author
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Bouton, D, primary, Escriva, H, additional, de Mendonça, R L, additional, Glineur, C, additional, Bertin, B, additional, Noël, C, additional, Robinson-Rechavi, M, additional, de Groot, A, additional, Cornette, J, additional, Laudet, V, additional, and Pierce, R J, additional
- Published
- 2005
- Full Text
- View/download PDF
35. Selective phosphodiesterase inhibitors modulate the activity of alveolar macrophages from sensitized guinea-pigs
- Author
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Germain, N, primary, Bertin, B, additional, Legendre, A, additional, Martin, B, additional, Lagente, V, additional, Payne, A, additional, and Boichot, E, additional
- Published
- 1998
- Full Text
- View/download PDF
36. β-Adrenergic and Muscarinic Receptor Expression are Regulated in Opposite Ways During Senescence in Rat Left Ventricle
- Author
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Hardouin, S., primary, Mansier, P., additional, Bertin, B., additional, Dakhly, T., additional, Swynghedauw, B., additional, and Moalic, J.M., additional
- Published
- 1997
- Full Text
- View/download PDF
37. Decreased heart rate variability in transgenic mice overexpressing atrial beta 1-adrenoceptors
- Author
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Mansier, P., primary, Medigue, C., additional, Charlotte, N., additional, Vermeiren, C., additional, Coraboeuf, E., additional, Deroubai, E., additional, Ratner, E., additional, Chevalier, B., additional, Clairambault, J., additional, Carre, F., additional, Dahkli, T., additional, Bertin, B., additional, Briand, P., additional, Strosberg, D., additional, and Swynghedauw, B., additional
- Published
- 1996
- Full Text
- View/download PDF
38. Effect of Isoenzyme Selective Phosphodiesterase Inhibitors on the Proliferation of Murine Thymus and Spleen Cells
- Author
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Banner, K.H., primary, Bertin, B., additional, Moodley, I., additional, and Page, C.P., additional
- Published
- 1996
- Full Text
- View/download PDF
39. Characterization of Pharmacologically Active Anti‐Peptide Antibodies Directed Against the First and Second Extracellular Loops of the Serotonin 5‐HT1A Receptor
- Author
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Verdot, L., primary, Bertin, B., additional, Guilloteau, D., additional, Strosberg, A. D., additional, and Hoebeke, J., additional
- Published
- 1995
- Full Text
- View/download PDF
40. Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors
- Author
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Moodley, I., primary, Sotsios, Y., additional, and Bertin, B., additional
- Published
- 1995
- Full Text
- View/download PDF
41. Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor.
- Author
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Jockers, R, primary, Linder, M E, additional, Hohenegger, M, additional, Nanoff, C, additional, Bertin, B, additional, Strosberg, A D, additional, Marullo, S, additional, and Freissmuth, M, additional
- Published
- 1994
- Full Text
- View/download PDF
42. Cellular signaling by an agonist-activated receptor/Gs alpha fusion protein.
- Author
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Bertin, B, primary, Freissmuth, M, additional, Jockers, R, additional, Strosberg, A D, additional, and Marullo, S, additional
- Published
- 1994
- Full Text
- View/download PDF
43. Production of anti-peptide antibodies directed against the first and the second extracellular loop of the human serotonin 5-HT1A receptor
- Author
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Verdot, L., primary, Ferrer-di-Martino, M., additional, Bertin, B., additional, Strosberg, A.D., additional, and Hoebeke, J., additional
- Published
- 1994
- Full Text
- View/download PDF
44. Specific atrial overexpression of G protein coupled human 1 adrenoceptors in transgenic mice
- Author
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Bertin, B., primary, Mansier, P., additional, Makeh, I., additional, Briand, P., additional, Rostene, W., additional, Swynghedauw, B., additional, and Strosberg, A D., additional
- Published
- 1993
- Full Text
- View/download PDF
45. Quand les bactéries nous montrent comment fonctionnent les récepteurs humains
- Author
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Marullo, S, primary, Bertin, B, additional, Freissmuth, M, additional, and Strosberg, AD, additional
- Published
- 1992
- Full Text
- View/download PDF
46. Dossier transfusionnel et techniques de groupage sanguin : éléments essentiels de la sécurité transfusionnelle
- Author
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Clavier, B, Trueba, F, Bertin, B, Descraques, C, Hernandez, E, and Joussemet, M
- Published
- 2002
- Full Text
- View/download PDF
47. A conserved retinoid X receptor (RXR) from the mollusk Biomphalaria glabratatransactivates transcription in the presence of retinoids
- Author
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Bouton, D, Escriva, H, de Mendonça, R L, Glineur, C, Bertin, B, Noël, C, Robinson-Rechavi, M, de Groot, A, Cornette, J, Laudet, V, and Pierce, R J
- Abstract
Retinoid X receptors (RXR) are members of the nuclear receptor superfamily of ligand-activated transcription factors that have been characterized in a wide variety of metazoan phyla. They act as heterodimer partners of other nuclear receptors, and in vertebrates also activate transcription as homodimers in the presence of a ligand, 9-cisretinoic acid. In order to test the hypothesis that retinoic acid signaling pathways involving RXRs are present in the Lophotrochozoa, we have sought to isolate conserved members of this family from the platyhelminth parasite Schistosoma mansoniand its intermediate host, the mollusk Biomphalaria glabrata.Here we report that an RXR ortholog from B. glabrata(BgRXR) is better conserved, compared with mouse RXRα, both in the DNA-binding domain (89% identity) and in the ligand-binding domain (LBD) (81% identity), than are arthropod homologs. In EMSA, BgRXR binds to the direct repeat response element DR1 as a homodimer or as a heterodimer with mammalian RARα, LXR, FXR or PPARα. When transfected alone into mammalian cell lines, BgRXR transactivated transcription of a reporter gene from the Apo-A1 promoter in the presence of 9-cisretinoic acid or DHA. Constructs with the Gal4 DNA binding domain fused to the hinge and LBDs of BgRXR were used to show that ligand-dependent activation of transcription by BgRXR required its intact AF-2 activation domain, and that the LBD can form homodimers. Finally, the binding of 9-cisretinoic acid preferentially protected the LBD of BgRXR from degradation by trypsin in a proteolysis protection assay. Our results show that BgRXR binds and is activated by retinoids and suggest that retinoid signaling pathways are conserved in the Lophotrochozoa. The nucleotide sequence reported in this paper has been submitted to the GenBank/EBI Data Bank with accession no. AY048663.
- Published
- 2005
- Full Text
- View/download PDF
48. Leukemogenic effect of human leukemic materials. Attempts to enhance effect in mice by combination of materials with inactivated mouse leukemia virus.
- Author
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Sinkovics, Joseph G., Shullenberger, C. C., Howe, Clifton D., Bertin, Barbara A., Sinkovics, J G, Howe, C D, and Bertin, B A
- Published
- 1967
- Full Text
- View/download PDF
49. A system of tissue cultures for the study of a mouse leukemia virus.
- Author
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Sinkovics, J. G., Groves, Glenda F., Bertin, Barbara A., Shullenberger, C. C., Groves, G F, and Bertin, B A
- Published
- 1969
- Full Text
- View/download PDF
50. Synthesis, Structure−Activity Relationships, and Pharmacological Profile of 9-Amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indoles: Discovery of Potent, Selective Phosphodiesterase Type 4 Inhibitors
- Author
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Burnouf, C., Auclair, E., Avenel, N., Bertin, B., Bigot, C., Calvet, A., Chan, K., Durand, C., Fasquelle, V., Feru, F., Gilbertsen, R., Jacobelli, H., Kebsi, A., Lallier, E., Maignel, J., Martin, B., Milano, S., Ouagued, M., Pascal, Y., Pruniaux, M.-P., Puaud, J., Rocher, M.-N., Terrasse, C., Wrigglesworth, R., and Doherty, A. M.
- Abstract
The synthesis, structure−activity relationships, and biological properties of a novel series of potent and selective phosphodiesterase type 4 (PDE4) inhibitors are described. These new aminodiazepinoindoles displayed in vitro PDE4 activity with submicromolar IC
50 values and PDE4 selectivity vs PDE1, -3, and -5. Specifically, one compound (CI-1044,10e ) provided efficient in vitro inhibition of TNFα release from hPBMC and hWB with IC50 values of 0.34 and 0.84 μM, respectively. This compound was found to exhibit potent in vivo activity in antigen-induced eosinophil recruitment in Brown-Norway rats (ED50 = 3.2 mg/kg po) and in production of TNFα in Wistar rats (ED50 = 2.8 mg/kg po). No emetic side effects at therapeutic doses were observed in ferrets.- Published
- 2000
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