Search

Your search keyword '"Bertorelli G"' showing total 150 results
Start Over Author "Bertorelli G"
150 results on '"Bertorelli G"'

1. Detection of Small Airway Dysfunction in Asymptomatic Smokers with Preserved Spirometry: The Value of the Impulse Oscillometry System

Author

Pisi R, Aiello M, Frizzelli A, Calzetta L, Marchi L, Bertorelli G, Pisi G, and Chetta A

Subjects
small airway dysfunction, impulse oscillometry system, spirometry, smokers, copd, Diseases of the respiratory system, RC705-779
Abstract

Roberta Pisi,1 Marina Aiello,1 Annalisa Frizzelli,1 Luigino Calzetta,1 Laura Marchi,1 Giuseppina Bertorelli,1 Giovanna Pisi,2 Alfredo Chetta1 1Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, Italy; 2Department of Pediatrics, Cystic Fibrosis Center, University Hospital, Parma, ItalyCorrespondence: Luigino CalzettaDepartment of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Viale A. Gramsci, 14, Parma, 43126, ItalyEmail luigino.calzetta@unipr.itPurpose: Smoking-induced bronchiolitis with progressive small airway dysfunction (SAD) is a leading cause of chronic obstructive pulmonary disease. We investigated the value of using the impulse oscillometry system (IOS) to detect SAD in asymptomatic smokers with preserved spirometry.Patients and Methods: We included 75 asymptomatic smokers (37 females, mean age 47± 12 years, 26± 17 pack/year) with preserved spirometry [forced expiratory volume at 1st second (FEV1)/forced vital capacity (FVC) ≥ 0.70 and normal FVC] and 34 never-smokers (19 females, mean age 42± 15 years).Results: In smokers, pack/years were significantly related to spirometry and IOS parameters (p < 0.05). The values of the fall in resistance from 5 Hz to 20 Hz (R5 – R20) were significantly and inversely related to the values of the ratio of forced expiratory volume in 3 and in 6 seconds (FEV3/FEV6) (p < 0.05). In addition, the percentage of heavy smokers (≥ 30 pack/year) with R5 – R20 > 0.07 kPa·s·L− 1, considered as IOS index of SAD, but not with FEV3/FEV6 less than a lower limit of normal, a spirometry index of SAD, was significantly higher than that of mild smokers (< 30 pack/year) and never-smokers (p < 0.05).Conclusion: This study demonstrates that IOS has the potential to detect SAD in asymptomatic heavy smokers with preserved spirometry and with FEV3/FEV6 values in the normal range. We confirm that IOS provides parameters which can complement traditional measurements of pulmonary function.Keywords: small airway dysfunction, impulse oscillometry system, spirometry, smokers, COPD

Published
2021

2. Left ventricular structure and remodeling in patients with COPD

Author

Pelà G, Li Calzi M, Pinelli S, Andreoli R, Sverzellati N, Bertorelli G, Goldoni M, and Chetta A

Subjects
COPD, Doppler tissue echocardiography, left ventricular remodeling, emphysema score, right ventricular function, left ventricular function, Diseases of the respiratory system, RC705-779
Abstract

Giovanna Pelà,1 Mauro Li Calzi,1 Silvana Pinelli,1 Roberta Andreoli,1 Nicola Sverzellati,2 Giuseppina Bertorelli,1 Matteo Goldoni,1 Alfredo Chetta11Department of Clinical and Experimental Medicine, 2Department of Surgery, University Medical School, University Hospital Parma, Parma, ItalyBackground: Data on cardiac alterations such as left ventricular (LV) hypertrophy, diastolic dysfunction, and lower stroke volume in patients with COPD are discordant. In this study, we investigated whether early structural and functional cardiac changes occur in patients with COPD devoid of manifest cardiovascular disease, and we assessed their associations with clinical and functional features.Methods: Forty-nine patients with COPD belonging to all Global Initiative for Chronic Obstructive Lung Disease (GOLD) classes were enrolled and compared with 36 controls. All subjects underwent clinical history assessment, lung function testing, blood pressure measurement, electrocardiography, and conventional and Doppler tissue echocardiography. Patients were also subjected to computed tomography to quantify emphysema score.Results: Patients with COPD had lower LV cavity associated with a marked increase in relative wall thickness (RWT), suggesting concentric remodeling without significant changes in LV mass. RWT was significantly associated with ratio of the forced expiratory volume in 1 second to the forced vital capacity and emphysema score and was the only cardiac parameter that – after multivariate analysis – significantly correlated with COPD conditions in all individuals. Receiver operating characteristic curve analysis showed that RWT (with a cutoff point of 0.42) predicted the severity of COPD with 83% specificity and 56% sensitivity (area under the curve =0.69, 95% confidence interval =0.59–0.81). Patients with COPD showed right ventricular to be functional but no structural changes.Conclusion: Patients with COPD without evident cardiovascular disease exhibit significant changes in LV geometry, resulting in concentric remodeling. In all individuals, RWT was significantly and independently related to COPD. However, its prognostic role should be determined in future studies.Keywords: COPD, Doppler tissue echocardiography, left ventricular remodeling, emphysema score, right ventricular function, left ventricular function

Published
2016

6. Alpha-1 antitrypsin deficiency is significantly associated with atopy in asthmatic patients.

Author

Aiello, M., Frizzelli, A., Pisi, R., Fantin, A., Ghirardini, M., Marchi, L., Ferrarotti, I., Bertorelli, G., Percesepe, A., and Chetta, A.

Subjects
TRYPSIN inhibitors, ATOPY, ETIOLOGY of diseases, BLOOD serum analysis, GENETIC mutation, WHEEZE
Abstract

Background: Although the etiology and disease mechanisms of asthma and alpha-1 antitrypsin deficiency (AATD) are distinct, several reports indicate that asthma is common in AATD patients, however the relationships between asthma and AATD are poorly described in the literature. Objectives: The aim of the study was to investigate in a cohort of outpatients affected by mild to moderate asthma the clinical features that may differentiate asthmatic patients with and without mutation on SERPINA1 gene. Methods: Seven hundred thirty-five asthmatic outpatients underwent quantitative analysis of the serum level of alpha-1antitrypsin. According to the literature only sixty-seven out of seven hundred thirty-five asthmatic patients were submitted to genetic analysis to identify AATD and non-AATD subjects. Fifty-eight patients were studied. Clinical and functional data, including lung function, atopy and bronchial hyperactivity, were recorded. Results: The fifty-eight asthmatic patients were divided in AATD patients (n = 22) and non AATD patients (n = 36), according to genotype. The presence of atopy was significantly higher in patients with AATD than in those without AATD (91% vs. 64%; p = 0.031). AATD patients reported allergic manifestations more than non AATD patients (77% vs. 47%; p = 0.030). Conclusion: Our study shows that the presence of atopy in asthmatic patients with AATD is significantly higher than in asthmatic patients without gene mutation. In addition, a higher percentage of AATD patients self-reported allergic manifestations. No significant differences in respiratory symptoms, physical examination, disease severity or inflammation markers were found between AATD patients and non AATD patients. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

13. Structured reporting for fibrosing lung disease: a model shared by radiologist and pulmonologist

Author

Sverzellati, N, Odone, A, Silva, M, Polverosi, R, Florio, C, Cardinale, L, Cortese, G, Addonisio, G, Zompatori, M, Dalpiaz, G, Piciucchi, S, Larici, A, Agostini, C, Albera, C, Attinà, D, Battista, G, Bertelli, E, Bertorelli, G, Bnà, C, Bonifazi, M, Bonomo, L, Borghesi, A, Calandriello, L, Caminati, A, Capannelli, D, Cerri, S, Ciccarese, F, Colombi, D, Confalonieri, M, Del Ciello, A, della Casa, G, Dore, R, Falaschi, F, Farchione, A, Feragalli, B, Franchi, P, Gavelli, G, Harari, S, Luppi, F, Maggi, F, Mazzei, M, Mereu, M, Milanese, G, Palmucci, S, Patea, R, Pesci, A, Piolanti, M, Poletti, V, Rea, G, Richeldi, L, Rogliani, P, Romei, C, Rottoli, P, Sanduzzi-Zamparelli, A, Sebastiani, A, Sergiacomi, G, Soardi, G, Spaggiari, L, Spagnolo, P, Tomassetti, S, Trisolini, R, Valentini, A, Vancheri, C, Vespro, V, Volterrani, L, Sverzellati, Nicola, Odone, Anna, Silva, Mario, Polverosi, Roberta, Florio, Carlo, Cardinale, Luciano, Cortese, Giancarlo, Addonisio, Giancarlo, Zompatori, Maurizio, Dalpiaz, Giorgia, Piciucchi, Sara, Larici, Anna Rita, Agostini, Carlo, Albera, Carlo, Attinà, Domenico, Battista, Giuseppe, Bertelli, Elena, Bertorelli, Giuseppina, Bnà, Claudio, Bonifazi, Martina, Bonomo, Lorenzo, Borghesi, Andrea, Calandriello, Lucio, Caminati, Antonella, Capannelli, Diana, Cerri, Stefania, Ciccarese, Federica, Colombi, Davide, Confalonieri, Marco, Del Ciello, Annaemilia, della Casa, Giovanni, Dore, Roberto, Falaschi, Fabio, Farchione, Alessandra, Feragalli, Beatrice, Franchi, Paola, Gavelli, Giampaolo, Harari, Sergio, Luppi, Fabrizio, Maggi, Fabio, Mazzei, Maria Antonietta, Mereu, Manuela, Milanese, Gianluca, Palmucci, Stefano, Patea, Rosa Lucia, Pesci, Alberto, Piolanti, Marco, Poletti, Venerino, Rea, Gaetano, Richeldi, Luca, Rogliani, Paola, Romei, Chiara, Rottoli, Paola, Sanduzzi-Zamparelli, Alessandro, Sebastiani, Alfredo, Sergiacomi, Gianluigi, Soardi, Gian Alberto, Spaggiari, Lucia, Spagnolo, Paolo, Tomassetti, Sara, Trisolini, Rocco, Valentini, Adele, Vancheri, Carlo, Vespro, Valentina, Volterrani, Luca, Sverzellati, N, Odone, A, Silva, M, Polverosi, R, Florio, C, Cardinale, L, Cortese, G, Addonisio, G, Zompatori, M, Dalpiaz, G, Piciucchi, S, Larici, A, Agostini, C, Albera, C, Attinà, D, Battista, G, Bertelli, E, Bertorelli, G, Bnà, C, Bonifazi, M, Bonomo, L, Borghesi, A, Calandriello, L, Caminati, A, Capannelli, D, Cerri, S, Ciccarese, F, Colombi, D, Confalonieri, M, Del Ciello, A, della Casa, G, Dore, R, Falaschi, F, Farchione, A, Feragalli, B, Franchi, P, Gavelli, G, Harari, S, Luppi, F, Maggi, F, Mazzei, M, Mereu, M, Milanese, G, Palmucci, S, Patea, R, Pesci, A, Piolanti, M, Poletti, V, Rea, G, Richeldi, L, Rogliani, P, Romei, C, Rottoli, P, Sanduzzi-Zamparelli, A, Sebastiani, A, Sergiacomi, G, Soardi, G, Spaggiari, L, Spagnolo, P, Tomassetti, S, Trisolini, R, Valentini, A, Vancheri, C, Vespro, V, Volterrani, L, Sverzellati, Nicola, Odone, Anna, Silva, Mario, Polverosi, Roberta, Florio, Carlo, Cardinale, Luciano, Cortese, Giancarlo, Addonisio, Giancarlo, Zompatori, Maurizio, Dalpiaz, Giorgia, Piciucchi, Sara, Larici, Anna Rita, Agostini, Carlo, Albera, Carlo, Attinà, Domenico, Battista, Giuseppe, Bertelli, Elena, Bertorelli, Giuseppina, Bnà, Claudio, Bonifazi, Martina, Bonomo, Lorenzo, Borghesi, Andrea, Calandriello, Lucio, Caminati, Antonella, Capannelli, Diana, Cerri, Stefania, Ciccarese, Federica, Colombi, Davide, Confalonieri, Marco, Del Ciello, Annaemilia, della Casa, Giovanni, Dore, Roberto, Falaschi, Fabio, Farchione, Alessandra, Feragalli, Beatrice, Franchi, Paola, Gavelli, Giampaolo, Harari, Sergio, Luppi, Fabrizio, Maggi, Fabio, Mazzei, Maria Antonietta, Mereu, Manuela, Milanese, Gianluca, Palmucci, Stefano, Patea, Rosa Lucia, Pesci, Alberto, Piolanti, Marco, Poletti, Venerino, Rea, Gaetano, Richeldi, Luca, Rogliani, Paola, Romei, Chiara, Rottoli, Paola, Sanduzzi-Zamparelli, Alessandro, Sebastiani, Alfredo, Sergiacomi, Gianluigi, Soardi, Gian Alberto, Spaggiari, Lucia, Spagnolo, Paolo, Tomassetti, Sara, Trisolini, Rocco, Valentini, Adele, Vancheri, Carlo, Vespro, Valentina, and Volterrani, Luca

Abstract

Objectives: To apply the Delphi exercise with iterative involvement of radiologists and pulmonologists with the aim of defining a structured reporting template for high-resolution computed tomography (HRCT) of patients with fibrosing lung disease (FLD). Methods: The writing committee selected the HRCT criteria—the Delphi items—for rating from both radiology panelists (RP) and pulmonology panelists (PP). The Delphi items were first rated by RPs as “essential”, “optional”, or “not relevant”. The items rated “essential” by < 80% of the RP were selected for the PP rating. The format of reporting was rated by both RP and PP. Results: A total of 42 RPs and 12 PPs participated to the survey. In both Delphi round 1 and 2, 10/27 (37.7%) items were rated “essential” by more than 80% of RP. The remaining 17/27 (63.3%) items were rated by the PP in round 3, with 2/17 items (11.7%) rated “essential” by the PP. PP proposed additional items for conclusion domain, which were rated by RPs in the fourth round. Poor consensus was observed for the format of reporting. Conclusions: This study provides a template for structured report of FLD that features essential items as agreed by expert thoracic radiologists and pulmonologists

Published
2018

15. Regular versus as-needed budesonide and formoterol combination treatment for moderate asthma: A non-inferiority, randomised, double-blind clinical trial

Author

Papi, Alberto, Marku, Brunilda, Scichilone, N., Maestrelli, P., Paggiaro, P., Saetta, M., Nava, S., Folletti, I., Bertorelli, G., Bertacco, S., Contoli, Marco, Plebani, M., Foschino, M. P., Spanevello, A., Aliani, M., Pannacci, M., Morelli, P., Beghé, B., Fabbri, L. M., Aifasma, f. t., Papi, A., Marku, B., Scichilone, N., Maestrelli, P., Paggiaro, P., Saetta, M., Nava, S., Folletti, I., Bertorelli, G., Bertacco, S., Contoli, M., Plebani, M., Barbaro, M., Spanevello, A., Aliani, M., Pannacci, M., Morelli, P., Beghé, B., Fabbri, L., Papi, Alberto, Marku, Brunilda, Scichilone, Nicola, Maestrelli, Piero, Paggiaro, Pierluigi, Saetta, Marina, Nava, Stefano, Folletti, Ilenia, Bertorelli, Giuseppina, Bertacco, Stefano, Contoli, Marco, Plebani, Mario, Barbaro, Maria Pia Foschino, Spanevello, Antonio, Aliani, Maria, Pannacci, Marco, Morelli, Paolo, Beghé, Bianca, and Fabbri, Leonardo M

Subjects
Budesonide, Male, Pediatrics, Kaplan-Meier Estimate, law.invention, Randomized controlled trial, law, Medicine, Outpatient clinic, Budesonide, Formoterol Fumarate Drug Combination, Anti-Asthmatic Agents, Treatment Failure, education.field_of_study, asthma, clinical trial, Medicine (all), Middle Aged, Combined Modality Therapy, Bronchodilator Agents, Female, medicine.drug, Human, Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adolescent, Terbutaline, Population, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Placebo, Drug Administration Schedule, NO, Young Adult, Double-Blind Method, Administration, Inhalation, inhaled corticosteroids, LABA, asthma, clinical trial, Humans, Anti-Asthmatic Agent, education, Bronchodilator Agent, Asthma, Aged, Pulmonary and Respiratory Medicine, RCT, asthma, business.industry, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, medicine.disease, respiratory tract diseases, Formoterol, business
Abstract

Summary Background Treatment guidelines for patients with moderate persistent asthma recommend regular therapy with a combination of an inhaled corticosteroid and a longacting β 2 agonist plus as-needed rapid-acting bronchodilators. We investigated whether symptom-driven budesonide and formoterol combination therapy administered as needed would be as effective as regular treatment with this combination plus as-needed symptom-driven terbutaline for patients with moderate asthma. Methods In this non-inferiority randomised clinical trial, we recruited adult patients (18–65 years of age) with stable moderate persistent asthma, according to 2006 Global Initiative for Asthma guidelines. Patients were recruited from outpatient clinics of secondary and tertiary referral hospitals and university centres. After a 6-week run-in period of inhaled regular budesonide and formoterol plus as-needed terbutaline, the patients were randomly assigned in a 1:1 ratio to receive placebo twice daily plus as-needed treatment with inhaled 160 μg budesonide and 4·5 μg formoterol (as-needed budesonide and formoterol therapy) or twice-daily 160 μg budesonide and 4·5 μg formoterol combination plus symptom-driven 500 μg terbutaline (regular budesonide/formoterol therapy) for 1 year. Randomisation was done according to a list prepared with the use of a random number generator and a balanced-block design stratified by centre. Patients and investigators were masked to treatment assignment. The primary outcome was time to first treatment failure measured after 1 year of treatment using Kaplan-Meier estimates, and the power of the study was calculated based on the rate of treatment failure. Analyses were done on the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT00849095. Findings Between April 20, 2009, and March 31, 2012, we screened 1010 patients with moderate asthma and randomly assigned 866 eligible patients to the two treatment groups (424 to as-needed budesonide and formoterol therapy and 442 to regular budenoside and formoterol therapy). Compared with regular budesonide and formoterol therapy, as-needed budesonide and formoterol treatment was associated with a lower probability of patients having no treatment failure at 1 year (Kaplan-Meier estimates 53·6% for as-needed treatment vs 64·0% for regular treatment; difference 10·3% [95% CI 3·2–17·4], at a predefined non-inferiority limit of 9%). Patients in the as-needed budesonide and formoterol group had shorter time to first treatment failure than those in the regular therapy group (11·86 weeks vs 28·00 weeks for the first quartile [ie, the time until the first 25% of patients experienced treatment failure]). The difference in treatment failures was largely attributable to nocturnal awakenings (82 patients in the as-needed treatment group vs 44 in the regular treatment group). Both treatment regimens were well tolerated. Interpretation In patients with moderate stable asthma, as-needed budesonide and formoterol therapy is less effective than is the guideline-recommended regular budesonide and formoterol treatment, even though the differences are small. Funding Italian Medicines Agency.

Published
2015

18. Polmoniti da ipersensibilità

Author

Agostini, Carlo, Bertorelli, G., Marcer, Guido, Olivieri, D, Semenzato, GIANPIETRO CARLO, and Trentin, Livio

Subjects
Etiology, Hypersensitivity Pneumonitis, Epidemiology, Prevention, Diagnosis
Published
2002

20. Eziopatogenesi delle BPCO

Author

DI MARIA, Giuseppe Ugo, Olivieri, D, Vignola, M, Bertorelli, G, and Petruzzelli, S.

Published
2001

23. Alpha glucocorticoid receptor expression in different experimental rat models of acute lung injury

Author

Bertorelli, G, Pesci, A, Peveri, S, Mergoni, M, Corradi, A, Maria Cantoni, A, Tincani, G, Bobbio, A, Rusca, M, Carbognani, P, Carbognani, P., PESCI, ALBERTO, Bertorelli, G, Pesci, A, Peveri, S, Mergoni, M, Corradi, A, Maria Cantoni, A, Tincani, G, Bobbio, A, Rusca, M, Carbognani, P, Carbognani, P., and PESCI, ALBERTO

Abstract

BACKGROUND AND OBJECTIVES: Acute respiratory distress syndrome (ARDS) is a frequent form of hypoxiemic respiratory failure caused by the acute development of diffuse lung inflammation. Dysregulated systemic inflammation with persistent elevation of circulating inflammatory cytokines is the pathogenetic mechanism for pulmonary and extrapulmonary organ dysfunction in patients with ARDS. Glucocorticoids (GCs) have a broad range of inhibitory inflammatory effects, including inhibition of cytokines transcription, cellular activation and growth factor production. They inhibit the inflammatory pathways through two specific intracellular glucocorticoid receptors (GRs), named GR alpha and GR beta. The aim of our study was to evaluate the histologic evidence of inflammatory injury and the GR alpha uptake of resident and inflammatory cells in different experimental models of acute lung injury (ALI). METHODS: We studied four groups of rats: three different experimental rat models of lung injury and a control group. The ALI was caused by barotrauma (due to an overventilation), oleic acid injection and mechanical ventilation. Results were compared to nonventilated rat control group. The duration of mechanical ventilation was of 2.5h. At the end of each experiment, rats were sacrificed. Lung biopsies were evaluated for morphologic changes. The immunohistochemistry was performed to study GR alpha expression. RESULTS: Histologic evidence of lung injury (alveolar and interstitial edema, vascular congestion, alveolar haemorrhage, emphysema, number of interstitial cells and neutrophils, and destruction of alveolar attachments) were present in all ventilated groups. Barotrauma lead to an additional inflammatory response. GR alpha expression significantly increased in the three ventilated groups compared with nonventilated groups. GR alpha expression was highest in barotrauma group. CONCLUSIONS: These data indicate that ALI is associated with diffuse alveolar damage, up-regulation of the

Published
2008

42. Epidemiological survey on interstitial lung disease in Italy: Leopard-spot-like data and results | Inchiesta epidemiologica sulle interstiziopatie polmonari in Italia: Dati e risultati a macchia di leopardo

Author

Rizzato, G., Bariffi, F., Luisetti, M., Trisolini, R., Boccieri, M., Mazza, F., Ukmar, R., Nabergoi, M., Agostini, C., Gianpietro Semenzato, Bertorelli, G., Olivieri, D., Rossi, P., Benedetto, F., Liberati, R., Cioffi, R., Catena, E., D Amato, G., Petraglia, A., Scarpitta, M., Tranfa, C., Vero, G., Girbino, G., Ginesu, F., Rosetti, L., and Ledda, M.

46. Structured reporting for fibrosing lung disease: a model shared by radiologist and pulmonologist

Author

Sverzellati, Nicola, Odone, Anna, Silva, Mario, Polverosi, Roberta, Florio, Carlo, Cardinale, Luciano, Cortese, Giancarlo, Addonisio, Giancarlo, Zompatori, Maurizio, Dalpiaz, Giorgia, Piciucchi, Sara, Larici, Anna Rita, Agostini, Carlo, Albera, Carlo, Attinà, Domenico, Battista, Giuseppe, Bertelli, Elena, Bertorelli, Giuseppina, Bnà, Claudio, Bonifazi, Martina, Bonomo, Lorenzo, Borghesi, Andrea, Calandriello, Lucio, Caminati, Antonella, Capannelli, Diana, Cerri, Stefania, Ciccarese, Federica, Colombi, Davide, Confalonieri, Marco, Del Ciello, Annaemilia, della Casa, Giovanni, Dore, Roberto, Falaschi, Fabio, Farchione, Alessandra, Feragalli, Beatrice, Franchi, Paola, Gavelli, Giampaolo, Harari, Sergio, Luppi, Fabrizio, Maggi, Fabio, Mazzei, Maria Antonietta, Mereu, Manuela, Milanese, Gianluca, Palmucci, Stefano, Patea, Rosa Lucia, Pesci, Alberto, Piolanti, Marco, Poletti, Venerino, Rea, Gaetano, Richeldi, Luca, Rogliani, Paola, Romei, Chiara, Rottoli, Paola, Sanduzzi-Zamparelli, Alessandro, Sebastiani, Alfredo, Sergiacomi, Gianluigi, Soardi, Gian Alberto, Spaggiari, Lucia, Spagnolo, Paolo, Tomassetti, Sara, Trisolini, Rocco, Valentini, Adele, Vancheri, Carlo, Vespro, Valentina, Volterrani, Luca, Sverzellati, N, Odone, A, Silva, M, Polverosi, R, Florio, C, Cardinale, L, Cortese, G, Addonisio, G, Zompatori, M, Dalpiaz, G, Piciucchi, S, Larici, A, Agostini, C, Albera, C, Attinà, D, Battista, G, Bertelli, E, Bertorelli, G, Bnà, C, Bonifazi, M, Bonomo, L, Borghesi, A, Calandriello, L, Caminati, A, Capannelli, D, Cerri, S, Ciccarese, F, Colombi, D, Confalonieri, M, Del Ciello, A, della Casa, G, Dore, R, Falaschi, F, Farchione, A, Feragalli, B, Franchi, P, Gavelli, G, Harari, S, Luppi, F, Maggi, F, Mazzei, M, Mereu, M, Milanese, G, Palmucci, S, Patea, R, Pesci, A, Piolanti, M, Poletti, V, Rea, G, Richeldi, L, Rogliani, P, Romei, C, Rottoli, P, Sanduzzi-Zamparelli, A, Sebastiani, A, Sergiacomi, G, Soardi, G, Spaggiari, L, Spagnolo, P, Tomassetti, S, Trisolini, R, Valentini, A, Vancheri, C, Vespro, V, Volterrani, L, Sverzellati, N., Odone, A., Silva, M., Polverosi, R., Florio, C., Cardinale, L., Cortese, G., Addonisio, G., Zompatori, M., Dalpiaz, G., Piciucchi, S., Larici, A. R., Agostini, C., Albera, C., Attina, D., Battista, G., Bertelli, E., Bertorelli, G., Bna, C., Bonifazi, M., Bonomo, L., Borghesi, A., Calandriello, L., Caminati, A., Capannelli, D., Cerri, S., Ciccarese, F., Colombi, D., Confalonieri, M., Del Ciello, A., Della Casa, G., Dore, R., Falaschi, F., Farchione, A., Feragalli, B., Franchi, P., Gavelli, G., Harari, S., Luppi, F., Maggi, F., Mazzei, M. A., Mereu, M., Milanese, G., Palmucci, S., Patea, R. L., Pesci, A., Piolanti, M., Poletti, V., Rea, G., Richeldi, L., Rogliani, P., Romei, C., Rottoli, P., Sanduzzi-Zamparelli, A., Sebastiani, A., Sergiacomi, G., Soardi, G. A., Spaggiari, L., Spagnolo, P., Tomassetti, S., Trisolini, R., Valentini, A., Vancheri, C., Vespro, V., Volterrani, L., Sverzellati, Nicola, Odone, Anna, Silva, Mario, Polverosi, Roberta, Florio, Carlo, Cardinale, Luciano, Cortese, Giancarlo, Addonisio, Giancarlo, Zompatori, Maurizio, Dalpiaz, Giorgia, Piciucchi, Sara, Larici, Anna Rita, Agostini, Carlo, Albera, Carlo, Attinà, Domenico, Battista, Giuseppe, Bertelli, Elena, Bertorelli, Giuseppina, Bnà, Claudio, Bonifazi, Martina, Bonomo, Lorenzo, Borghesi, Andrea, Calandriello, Lucio, Caminati, Antonella, Capannelli, Diana, Cerri, Stefania, Ciccarese, Federica, Colombi, Davide, Confalonieri, Marco, Del Ciello, Annaemilia, della Casa, Giovanni, Dore, Roberto, Falaschi, Fabio, Farchione, Alessandra, Feragalli, Beatrice, Franchi, Paola, Gavelli, Giampaolo, Harari, Sergio, Luppi, Fabrizio, Maggi, Fabio, Mazzei, Maria Antonietta, Mereu, Manuela, Milanese, Gianluca, Palmucci, Stefano, Patea, Rosa Lucia, Pesci, Alberto, Piolanti, Marco, Poletti, Venerino, Rea, Gaetano, Richeldi, Luca, Rogliani, Paola, Romei, Chiara, Rottoli, Paola, Sanduzzi-Zamparelli, Alessandro, Sebastiani, Alfredo, Sergiacomi, Gianluigi, Soardi, Gian Alberto, Spaggiari, Lucia, Spagnolo, Paolo, Tomassetti, Sara, Trisolini, Rocco, Valentini, Adele, Vancheri, Carlo, Vespro, Valentina, and Volterrani, Luca

Subjects
Male, Research Report, Radiology, Nuclear Medicine and Imaging, Delphi Technique, Settore MED/10 - Malattie dell'Apparato Respiratorio, Pulmonary Fibrosis, Delphi method, Computed tomography, Standardized report, Consensus,High-resolution computed tomography, Lung fibrosis, Standardized report, Structured report, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Theoretical, Models, Nuclear Medicine and Imaging, Pulmonary Medicine, Prospective Studies, Tomography, Pulmonologists, High-resolution computed tomography, computer.programming_language, medicine.diagnostic_test, General Medicine, Middle Aged, X-Ray Computed, 030220 oncology & carcinogenesis, Consensus, Lung fibrosis, Structured report, Female, Radiology, Delphi round, Adult, Aged, Humans, Models, Theoretical, Tomography, X-Ray Computed, medicine.medical_specialty, Chest Radiology, education, Lung fibrosi, Consensu, 03 medical and health sciences, Settore MED/36 - Diagnostica per Immagini e Radioterapia, Structured reporting, medicine, business.industry, Pulmonologist, Lung disease, business, computer, Delphi
Abstract

Objectives To apply the Delphi exercise with iterative involvement of radiologists and pulmonologists with the aim of defining a structured reporting template for high-resolution computed tomography (HRCT) of patients with fibrosing lung disease (FLD). Methods The writing committee selected the HRCT criteria—the Delphi items—for rating from both radiology panelists (RP) and pulmonology panelists (PP). The Delphi items were first rated by RPs as “essential”, “optional”, or “not relevant”. The items rated “essential” by

Published
2017

47. Overall mortality in combined pulmonary fibrosis and emphysema related to systemic sclerosis

Author

Vanessa Hax, Carlo Alberto Scirè, Eugenio Arrigoni, Enrico Fusaro, Giuseppe Paolazzi, Flavio Cesare Bodini, G. Lucchini, Daniele Santilli, Alessandro Volpe, Mario Silva, Alarico Ariani, Rafael Mendonça da Silva Chakr, Markus Bredemeier, Giuseppina Bertorelli, M. Saracco, E. Bravi, Emanuele Michieletti, Fabio De Gennaro, Emanuele Bacchini, Valeria Seletti, Maria De Santis, F. Girelli, F. Mozzani, Luca Idolazzi, D. Imberti, Veronica Alfieri, Federica Lumetti, Alfredo Chetta, Dilia Giuggioli, Cristian Caimmi, Simone Parisi, Nicola Sverzellati, Ariani, A, Silva, M, Bravi, E, Parisi, S, Saracco, M, De Gennaro, F, Caimmi, C, Girelli, F, De Santis, M, Volpe, A, Lumetti, F, Hax, V, Bredemeier, M, Alfieri, V, Santilli, D, Bodini, F, Lucchini, G, Mozzani, F, Seletti, V, Bacchini, E, Arrigoni, E, Giuggioli, D, Chakr, R, Idolazzi, L, Bertorelli, G, Imberti, D, Michieletti, E, Paolazzi, G, Fusaro, E, Chetta, A, Scire, C, and Sverzellati, N

Subjects
Male, pulmonary fibrosi, systemic sclerosis, Kaplan-Meier Estimate, Gastroenterology, Scleroderma, Pulmonary function testing, 0302 clinical medicine, Pulmonary fibrosis, Prevalence, Immunology and Allergy, combined pulmonary fibrosis and emphysema, pulmonary fibrosis, semiquantitative chest CT, systemic sclerosis, skin and connective tissue diseases, Tomography, Lung function, combined pulmonary fibrosis and emphysema, pulmonary fibrosis, semiquantitative chest CT, Aged, Biomarkers, Female, Humans, Middle Aged, Prognosis, Pulmonary Emphysema, Pulmonary Fibrosis, Scleroderma, Systemic, Tomography, X-Ray Computed, Anticentromere antibodies, Enfisema pulmonar, integumentary system, respiratory system, Combined pulmonary fibrosis and emphysema, X-Ray Computed, medicine.anatomical_structure, Mortalidade, systemic sclerosi, Fibrose pulmonar idiopática, medicine.medical_specialty, Declaração de Helsinki, Estimativa de Kaplan-Meier, Immunology, Método, NO, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, In patient, 030203 arthritis & rheumatology, Lung, business.industry, Systemic, Escleroderma sistêmico, medicine.disease, respiratory tract diseases, 030228 respiratory system, business
Abstract

ObjectivesThis multicentre study aimed to investigate the overall mortality of combined pulmonary fibrosis and emphysema (CPFE) in systemic sclerosis (SSc) and to compare CPFE-SSc characteristics with those of other SSc subtypes (with interstitial lung disease—ILD, emphysema or neither).MethodsChest CTs, anamnestic data, immunological profile and pulmonary function tests of patients with SSc were retrospectively collected. Each chest CT underwent a semiquantitative assessment blindly performed by three radiologists. Patients were clustered in four groups: SSc-CPFE, SSc-ILD, SSc-emphysema and other-SSc (without ILD nor emphysema). The overall mortality of these groups was calculated by Kaplan-Meier method and compared with the stratified log-rank test; Kruskal-Wallis test, t-Student test and χ² test assessed the differences between groups. PResultsWe enrolled 470 patients (1959 patient-year); 15.5 % (73/470) died during the follow-up. Compared with the SSc-ILD and other-SSc, in SSc-CPFE there was a higher prevalence of males, lower anticentromere antibodies prevalence and a more reduced pulmonary function (pConclusionsCPFE increases the mortality risk in SSc along with a highly impaired lung function. These findings strengthen the importance to take into account emphysema in patients with SSc with ILD.

Published
2019

48. Alpha glucocorticoid receptor expression in different experimental rat models of acute lung injury

Author

Mario Mergoni, Silvia Peveri, Attilio Corradi, Giuseppina Bertorelli, Alberto Pesci, Giovanni Tincani, Paolo Carbognani, Antonio Bobbio, Anna Maria Cantoni, Michele Rusca, Dipartimento di Clinica Medica, Dipartimento di Salute Animale, University of Parma = Università degli studi di Parma [Parme, Italie], Dipartimento di Scienze Chirurgiche, Bertorelli, G, Pesci, A, Peveri, S, Mergoni, M, Corradi, A, Maria Cantoni, A, Tincani, G, Bobbio, A, Rusca, M, Carbognani, P, and University of Groningen

Subjects
Male, ARDS, Pathology, Glucocorticoid receptor alpha, medicine.medical_treatment, NF-KAPPA-B, RESPIRATORY-DISTRESS-SYNDROME, Systemic inflammation, 0302 clinical medicine, Acute lung injury, alpha glucocorticoid receptor, Acute lung injury, Pharmacology (medical), Diffuse alveolar damage, Lung, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Respiratory Distress Syndrome, HYPERVENTILATION, respiratory system, Barotraumas, Glucocorticoid acquired resistance, Immunohistochemistry, 3. Good health, BINDING AFFINITY, medicine.anatomical_structure, Barotrauma, Medicine, medicine.symptom, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Lung inflammation, BETA, Inflammation, Lung injury, PRESSURE, Proinflammatory cytokine, 03 medical and health sciences, Receptors, Glucocorticoid, INFLAMMATION, medicine, Animals, Rats, Wistar, 030304 developmental biology, Mechanical ventilation, MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, business.industry, Biochemistry (medical), SEPTIC SHOCK, medicine.disease, Respiration, Artificial, MECHANICAL VENTILATION, Rats, Disease Models, Animal, 030228 respiratory system, Immunology, business, RESISTANCE, Oleic Acid
Abstract

Background and objectives: Acute respiratory distress syndrome (ARDS) is a frequent form of hypoxiemic respiratory failure caused by the acute development of diffuse lung inflammation. Dysregulated systemic inflammation with persistent elevation of circulating inflammatory cytokines is the pathogenetic mechanism for pulmonary and extrapulmonary organ dysfunction in patients with ARDS. Glucocorticoids (GCs) have a broad range of inhibitory inflammatory effects, including inhibition of cytokines transcription, cellular activation and growth factor production. They inhibit the inflammatory pathways through two specific intracellular glucocorticoid receptors (GRs), named GR alpha and GR beta. The aim Of Our study was to evaluate the histologic evidence of inflammatory injury and the GRa uptake of resident and inflammatory cells in different experimental models of acute lung injury (ALI).Methods: We studied four groups of rats: three different experimental rat models of lung injury and a control group. The ALI was caused by barotrauma (due to an overventilation), oleic acid injection and mechanical ventilation. Results were compared to nonventilated rat control group. The duration of mechanical ventilation was of 2.5 h. At the end of each experiment, rats were sacrificed. Lung biopsies were evaluated for morphologic changes. The immunohistochemistry was performed to Study GR alpha expression.Results: Histologic evidence Of lung injury (alveolar and interstitial edema, vascular congestion, alveolar haemorrhage, emphysema, number of interstitial cells and neutrophils, and destruction of alveolar attachments) were present in all ventilated groups. Barotrauma lead to an additional inflammatory response. GR alpha expression significantly increased in the three ventilated groups compared with nonventilated groups. GR alpha expression was highest in barotrauma group.Conclusions: These data indicate that ALI is associated with diffuse alveolar damage, up-regulation of the inflammatory response and GR alpha overexpression. Barotrauma is the most effective mechanism inducing acute lung inflammation and GR alpha overexpression. (c) 2007 Elsevier Ltd. All rights reserved.

Published
2006

49. The interplay between diabetes mellitus and chronic obstructive pulmonary disease.

Author

Frizzelli A, Aiello M, Calzetta L, Bertorelli G, and Chetta A

Subjects
Humans, Comorbidity, Risk Factors, Diabetes Mellitus epidemiology, Hyperglycemia complications, Hyperglycemia epidemiology, Pulmonary Disease, Chronic Obstructive complications, Pulmonary Disease, Chronic Obstructive epidemiology
Abstract

Chronic obstructive pulmonary disease (COPD) and diabetes mellitus (DM) are common and chronic disorders. COPD is characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities and it is considered currently the fourth leading cause of death worldwide. DM is a systemic disease characterized by a chronic hyperglycemia associated with inflammation and oxidative stress. The relationship between the two conditions is not completely understood and conflicting results are reported in the literature. Many studies have investigated the mechanisms through with the respiratory disease is associated with an increased risk of metabolic condition or whether the incidence risk of COPD in individuals affected by DM is higher. The link between the two chronic conditions has relevant implications in the management of patients affected by the both of them. Respiratory patients should be screened for diabetes mellitus as a frequent comorbidity of lung disease since therapeutic options should be assessed about risk-to-benefit ratios associated with the indication for the steroid use. Furthermore, the role of hyperglycemia on pulmonary function (e.g. infection or inflammatory processes) should be evaluated in DM. Finally, in presence of both diseases potential treatment interactions should be considered. In this overview we explored the common aspects of both clinical chronic illnesses and investigated the interplay between the two conditions.

Published
2023
Full Text
View/download PDF

50. Beyond the lung involvement in COVID-19 patients.

Author

Tuttolomondo D, Frizzelli A, Aiello M, Bertorelli G, Majori M, and Chetta A

Subjects
Humans, Lung metabolism, Pandemics, SARS-CoV-2, COVID-19 complications
Abstract

Since COVID-19 spread all over the world becoming a pandemic illness, researchers have better characterized route of virus transmissibility and clinical signs and symptoms of the disease. Since viral transmission occurs through the droplets emitted during coughing or sneezing, the lungs are primarily affected. However, SARS-CoV-2 can affect several human organs due to high expressions of ACE2 receptor which is the main viral target, and the virus may affect not only higher and lower respiratory tracts, but also heart, kidney, gastro enteric tract, liver, pancreas, nervous system and skin. This review focuses on extra pulmonary involvement underlying atypical presentation of COVID-19. There is a great body of evidence concerning several human organ abnormalities associated to the SARS-CoV-2, enough to consider COVID-19 as a multisystemic and polyhedral disease.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results