4 results on '"Bertrand, Thierry Lavabre"'
Search Results
2. Les organoïdes pulmonaires
- Author
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Bourguignon, Chloé, Vernisse, Charlotte, Mianné, Joffrey, Fieldes, Mathieu, Ahmed, Engi, Petit, Aurélie, Vachier, Isabelle, Bertrand, Thierry Lavabre, Assou, Said, Bourdin, Arnaud, De Vos, John, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)
- Subjects
Gene Editing ,Tissue Scaffolds ,Pulmonary Gas Exchange ,[SDV]Life Sciences [q-bio] ,Cell Culture Techniques ,Bioengineering ,Respiratory Mucosa ,Carbon Dioxide ,Models, Biological ,Organoids ,Oxygen ,Alveolar Epithelial Cells ,Animals ,Humans ,Lung ,Cells, Cultured - Abstract
As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions of the respiratory epithelium with inserts in air/liquid interface (2D) or in organoids able to mimic up to the arborescence of the respiratory tree (3D). Recent development in the fields of pluripotent stem cells-derived organoids and genome editing technologies has provided new insights to better understand pulmonary diseases and to find new therapeutic perspectives.Les organoïdes pulmonaires.L’impact en santé publique des pathologies respiratoires chroniques ne cesse de croître. Dans ce contexte, il paraît indispensable d’améliorer les modèles d’études du poumon afin de reproduire au plus proche l’architecture pulmonaire complexe, garante des fonctions d’oxygénation et d’épuration du gaz carbonique. Les connaissances actuelles en physiopathologie respiratoire résultent en partie des études de modèles de reconstitution d’épithélium bronchique in vitro à partir de cellules primaires, en deux dimensions sur des inserts, ou en trois dimensions, en organoïdes mimant jusqu’à l’arborescence pulmonaire. Le développement de ces modèles in vitro a connu un nouvel essor grâce aux organoïdes pulmonaires issus de cellules souches pluripotentes et la démocratisation des outils d’édition du génome. Ces apports technologiques récents offrent de nouvelles perspectives en matière de thérapeutiques ou de compréhension physiopathologique et pourraient, dans le futur, ouvrir les portes de la médecine régénératrice pulmonaire.
- Published
- 2020
3. Organoïdes (6) Les organoïdes pulmonaires.
- Author
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Bourguignon, Chloé, Vernisse, Charlotte, Mianné, Joffrey, Fieldès, Mathieu, Ahmed, Engi, Petit, Aurélie, Vachier, Isabelle, Bertrand, Thierry Lavabre, Assou, Said, Bourdin, Arnaud, and De Vos, John
- Published
- 2020
- Full Text
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4. [Lung organoids].
- Author
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Bourguignon C, Vernisse C, Mianné J, Fieldès M, Ahmed E, Petit A, Vachier I, Bertrand TL, Assou S, Bourdin A, and De Vos J
- Subjects
- Alveolar Epithelial Cells cytology, Alveolar Epithelial Cells physiology, Animals, Bioengineering methods, Bioengineering trends, Carbon Dioxide pharmacology, Carbon Dioxide physiology, Cells, Cultured, Gene Editing methods, Gene Editing trends, Humans, Lung pathology, Lung physiology, Models, Biological, Organoids pathology, Organoids physiology, Oxygen pharmacology, Oxygen physiology, Pulmonary Gas Exchange physiology, Respiratory Mucosa cytology, Respiratory Mucosa drug effects, Tissue Scaffolds chemistry, Cell Culture Techniques methods, Cell Culture Techniques trends, Lung cytology, Organoids cytology
- Abstract
As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions of the respiratory epithelium with inserts in air/liquid interface (2D) or in organoids able to mimic up to the arborescence of the respiratory tree (3D). Recent development in the fields of pluripotent stem cells-derived organoids and genome editing technologies has provided new insights to better understand pulmonary diseases and to find new therapeutic perspectives., (© 2020 médecine/sciences – Inserm.)
- Published
- 2020
- Full Text
- View/download PDF
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