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The temperature dependence of the heat capacity of betamethasone valerate in the range from 5.5 to 346 K was measured for the first time by precise vacuum adiabatic calorimetry. The thermodynamic functions of betamethasone valerate, namely, heat capacity, enthalpy H°(T) – H°(0), entropy S°(T) – S°(0), and Gibbs function G°(T) – H°(0) were determined for the temperature range from T → 0 to 350 K based on the experimental data. The thermal expansion coefficients were determined by low temperature powder X-ray diffractometry. [ABSTRACT FROM AUTHOR]

Umbilical granuloma (UG) is a common problem during the neonatal period; however, its epidemiology and etiology are poorly studied, and the best treatment option has not yet been established. We examined the medical records of neonates who were born and underwent 1-month evaluations at our hospital between 2013 and 2022 to investigate the frequency of—and factors associated with—UG, as well as the annual trends of UG treatments and their efficacy. Of the 6680 eligible neonates, 395 (5.9%) had UG. The annual incidence rate ranged from 3.8% to 7.3%. Gestational age, birth weight, and incidence of meconium-stained amniotic fluid were significantly associated with UG. Silver nitrate cauterization was the predominant UG treatment from 2013 to 2016. Silver nitrate cauterization and topical betamethasone valerate were nearly equally applied in 2017. Betamethasone application became predominant in 2018. The healing rates during the initial treatment period were 91% for silver nitrate cauterization, 97.7% for betamethasone application, 60% for ethanol disinfection, and 88% for ligation; these rates were significantly different (p < 0.001). Topical steroid application may be the most effective treatment. If steroid application is ineffective, then silver nitrate cauterization and ligation may be important treatment options. [ABSTRACT FROM AUTHOR]