350 results on '"Bethel, Christopher R."'
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2. Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity
3. A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp.
4. Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase‑1
5. Machine Learning Models Identify Inhibitors of New Delhi Metallo-β-lactamase.
6. The Structural Role of N170 in Substrate‐Assisted Deacylation in KPC‐2 β‐Lactamase.
7. The Effectiveness of Imipenem–Relebactam against Ceftazidime-Avibactam Resistant Variants of the KPC-2 β-Lactamase.
8. Understanding the determinants of substrate specificity in IMP family metallo-β-lactamases: The importance of residue 262
9. A kinetic analysis of the inhibition of FOX-4 β-lactamase, a plasmid-mediated AmpC cephalosporinase, by monocyclic β-lactams and carbapenems
10. Insights into the l,d-Transpeptidases and d,d-Carboxypeptidase of Mycobacterium abscessus: Ceftaroline, Imipenem, and Novel Diazabicyclooctane Inhibitors
11. Crystal structure of KPC-2: Insights into carbapenemase activity in class A [beta]-lactamases
12. Discovery of an Effective Small-Molecule Allosteric Inhibitor of New Delhi Metallo-β-lactamase (NDM).
13. Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone
14. Elucidating the role of Trp105 in the KPC-2 β-lactamase
15. Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA
16. Insights Into the Inhibition of MOX-1 β-Lactamase by S02030, a Boronic Acid Transition State Inhibitor.
17. Antibiotic resistance in the institutionalized elderly
18. Detection of SHV β-lactamases in Gram-negative bacilli using fluorescein-labeled antibodies
19. In vivo Evolution of CMY-2 to CMY-33 Beta-Lactamase in Escherichia coli ST131: Characterization of an Acquired Extended-Spectrum AmpC (ESAC)
20. Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase
21. Enhancing resistance to cephalosporins in class C [beta]-lactamases: impact of Gly214Glu in CMY-2
22. Inhibition of the class C [beta]-lactamase from Acinetobacter spp.: insights into effective inhibitor design
23. Why the extended-spectrum [beta]-lactamases SHV-2 and SHV-5 are 'hypersusceptible' to mechanism-based inhibitors
24. Mutation of the active site carboxy-lysine (K70) of OXA-1 [beta]-lactamase results in a deacylation-deficient enzyme
25. The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV [beta]-lactamase: a study of ambler position Asn276
26. Inhibition of class A [beta]-lactamases by carbapenems: crystallographic observation of two conformations of meropenem in SHV-1
27. Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 Angstrom crystal structure of wt SHV-1 complex with a penam sulfone
28. Inhibitor-resistant class A Beta-Lactamases: consequences of the Ser130-to-Gly mutation seen in apo and tazobactam structures of the SHV-1 variant
29. In vivo Evolution of CMY-2 to CMY-33 β-Lactamase in Escherichia coli ST131: Characterization of an Acquired Extended-Spectrum AmpC (ESAC) Conferring Resistance to Cefepime
30. A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli
31. Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1
32. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.
33. Strategic Design of an Effective β-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2′-SUBSTITUTED PENICILLIN SULFONE*S⃞
34. Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy
35. LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.
36. "Mind the Gap": Raman Evidence for Rapid Inactivation of CTX-M-9 β-Lactamase Using Mechanism-Based Inhibitors that Bridge the Active Site.
37. Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases.
38. Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 β-Lactamase and 6β-(Hydroxymethyl)penicillanic Acid Sulfone.
39. Boronic Acid Transition State Inhibitors Active against KPC and Other Class A β-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design
40. Following Drug Uptake and Reactions inside Escherichia coli Cells by Raman Microspectroscopy.
41. The Different Inhibition Mechanisms of OXA-1 and OXA-24 β-Lactamases Are Determined by the Stability of Active Site Carboxylated Lysine.
42. Penam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and Composition.
43. β-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-Enzyme.
44. In VivoEvolution of CMY-2 to CMY-33 β-Lactamase in Escherichia coliSequence Type 131: Characterization of an Acquired Extended-Spectrum AmpC Conferring Resistance to Cefepime
45. Elucidating the Role of Residue 67 in IMP-Type Metallo-β-Lactamase Evolution
46. Design and Explorationof Novel Boronic Acid InhibitorsReveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable(SHV) β-Lactamase.
47. Structures of SHV-1 β-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl Conjugation.
48. Crystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamase.
49. Carboxylation and Decarboxylation of Active Site Lys 84 Controls the Activity of OXA-24 β-Lactamase of Acinetobacter baumannii: Raman Crystallographic and Solution Evidence.
50. Intramuscularly administered peptide A3-APO is effective against carbapenem-resistant Acinetobacter baumannii in mouse models of systemic infections.
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