1. Comparison of outcomes of abdominoperineal resection vs low anterior resection in very-low rectal cancer.
- Author
-
Muldoon RL, Bethurum AJ, Gamboa AC, Zhang K, Ye F, Regenbogen SE, Abdel-Misih S, Ejaz A, Wise PE, Silviera M, Holder-Murray J, Balch GC, and Hawkins AT
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Disease-Free Survival, Treatment Outcome, Length of Stay statistics & numerical data, Retrospective Studies, Neoplasm Staging, Postoperative Complications epidemiology, Postoperative Complications etiology, Perineum surgery, Adult, Rectal Neoplasms surgery, Rectal Neoplasms pathology, Rectal Neoplasms mortality, Proctectomy methods, Neoplasm Recurrence, Local epidemiology
- Abstract
Background: The management of very-low rectal cancer is one of the most challenging issues faced by general and colorectal surgeons. Many feel compelled to pursue abdominoperineal resection (APR) over low anterior resection (LAR) to optimize oncologic outcomes. This study aimed to determine differences in long-term oncologic outcomes between patients undergoing APR or LAR for very-low rectal cancer., Methods: The United States Rectal Cancer Consortium (2010-2016) was queried for adults who underwent either APR or LAR for stage I-III rectal cancers < 5 cm from anorectal junction and met inclusion criteria. The primary outcome was disease-free survival. Secondary outcomes included overall survival, length of stay, complications, recurrence location, and perioperative factors., Results: A total of 431 patients with very-low rectal cancer who underwent APR or LAR were identified; 154 (35.7%) underwent APR. The overall recurrence rate was 19.6%. The median follow-up was 42.5 months. An analysis adjusted for demographics and pathologic stage observed no difference in disease-free survival between operative types (APR-hazard ratio [HR] = 0.90, 95% CI: 0.53-1.52, P = .70). Secondary outcomes demonstrated no significant difference between operation types, including overall survival (HR = 1.29, 95% CI: 0.71-2.32, P = .39), complications (OR = 1.53, 95% CI: 0.94-2.50, P = .12), or length of stay (estimate: 0.04, SE = 0.25, P = .54)., Conclusion: We observed no significant difference in disease-free survival or overall survival between patients undergoing APR or LAR for very-low rectal cancer. This analysis supports the treatment of very-low rectal cancer, without sphincter involvement, by either APR or LAR., Competing Interests: Declaration of Competing Interest The authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF