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Previous studies evaluating 15 mg/kg narasin have shown improvements in BW, ADG, G:F, and HCW and carcass yield when fed for an extended period of time (>60 days). However, a detailed evaluation of feeding duration of narasin has not been completed. This study evaluated the effect of narasin feeding duration on growth performance and carcass characteristics of growing-finishing pigs. The study was carried out over a fixed time of 112 days using 1,644 pigs in a randomized complete block design. Narasin was included at 15 mg/kg in the last two, three, or four growing-finishing dietary phases, which resulted in narasin being fed for the last 68, 94, or 112 days of study and compared with a negative control diet. Pigs were fed diets that met or exceeded nutrient recommendations of growing-finishing pigs (NRC, 2012). Pigs were offered ad libitum access to feed and water throughout the study and weighed every 28 days and at every marketing event. Feed additions and feed remaining in the feeder at the time of pig weighing were recorded. Pigs were sent for harvest to a commercial slaughter facility in three marketing groups: Group 1 - 20% of pigs marketed on day 84 of study, Group 2 - 20% of pigs marketed on day 98 of study, and Group 3 - remaining 60% of pigs marketed on day 112 of study. Standard carcass grading measurements were collected for each pig and summarized by pen for data analysis. There were limited statistical differences (P > 0.05) between treatments for growth or carcass measures, likely due to the limited number of replicates (n = 16) in this research facility. Nonetheless, there were numerical improvements from feeding narasin. Final live BW (+0.3, +0.4, +1.5 kg, respectively) and ADG (+0.1, +0.4, and +1.3%, respectively; Table 1) numerically increased with increased feeding duration of narasin. Overall G:F was relatively unaffected by feeding duration. Hot carcass weight increased with increased narasin feeding duration (+0.2, +1.1, +1.9 kg, respectively), resulting in increased carcass yield with increased feeding duration (-0.2, +0.1, +0.4 percentage units, respectively). Collectively, carcass ADG and carcass G:F trended toward improvement with increased feeding duration. Results of this study confirm previously observed improvements in growth performance from extended feeding of narasin compared with controls, suggesting that a greater response to narasin is observed with longer feeding durations. [ABSTRACT FROM AUTHOR]

Our objective was to determine the effects of increasing standardized ileal digestible (SID) lysine (Lys) levels on growth performance and carcass characteristics of late-nursery-to-finish pigs sired by PIC 800 boars. Barrows and gilts [n = 1,00; PIC800×Camborough, initial body weight (BW) = 10.9 ± 0.39 kg] were used in a 142-d growth trial with 40 mixed sex pens, 10 pens per treatment, and 25 pigs per pen. At the beginning of the trial, pens were blocked by BW and randomly allotted to one of four treatments (overall dietary SID Lys level as 87, 95, 102, or 110% of PIC SID Lys recommendations) in a randomized complete block design. Diets were corn-soybean meal (SBM)-based, and treatments were achieved through the inclusion of SBM with adjustments of corn and choice white grease. Diets were fed in 7 phases (11-17, 17-34, 34-44, 44-57, 57-77, 77-95, and 95-133 kg) and formulated to be iso-caloric across treatments for each phase. Within each phase, only the diets of the least and greatest SID Lys levels were manufactured, and the diets of intermediate SID Lys levels were blended by the automatic feeding system in the research facility. Growth performance data were analyzed using the GLIMMIX procedure in SAS (Version 9.4, SAS Institute, Inc., Cary, NC) and considered pen as the experimental unit. The statistical model considered fixed effects of SID Lys levels and random effects of the block. Mortality and removals were also analyzed using the GLIMMIX procedure and specified a binomial distribution. All data are reported as least square means and considered statistically significant at P < 0.05 and marginally significant at P < 0.10. Increasing overall dietary SID Lys levels reduced overall average daily feed intake (linear, P = 0.045) and increased overall gain-to-feed ratio (linear, P = 0.002), but there was no evidence for a difference across treatments for overall average daily gain (P > 0.10) or overall removal and mortality rate (Table 1; P >0.10). Pigs fed overall SID Lys level as 102% of PIC recommendation had significantly greater carcass yield compared with those fed 95 or 110% (P < 0.05), with the pigs fed 87% being intermediate. Increasing overall dietary SID Lys levels reduced backfat depth (linear, P< 0.001) and increased lean yield (linear, P = 0.012), but there was no evidence for a difference among treatments for loin depth (P > 0.10). In conclusion, increasing overall dietary SID Lys level beyond PIC recommendations through increasing SBM levels resulted in improved feed efficiency, backfat depth, and lean yield of 11 to 133 kg pigs sired by PIC 800 boars. [ABSTRACT FROM AUTHOR]

Two studies were conducted to estimate the SID Thr:Lys requirement for growth and feed efficiency of PIC 337×1050 pigs from approximately 12- to 70-kg. In Exp. 1, 987 pigs [initial body weight (BW) = 11.8±0.32 kg] were used from 12- to 24-kg. In Exp. 2,875 pigs (initial BW = 43.4±0.58 kg] were used from 43- to 70-kg. Pens of pigs were blocked by BW and randomly allotted to dietary treatments in randomized complete block designs, with 21 to 27 pigs per pen with 8 and 7 replications per treatment (Exp. 1 and 2, respectively). Pens were provided 1 of 5 dietary treatments with increasing SID Thr:Lys ratios at 53, 58, 62, 65, and 68% in each experiment. Two corn-soybean meal-based diets containing 53 and 68% Thr:Lys ratios were blended to achieve target SID Thr:Lys treatment levels in each experiment. In Exp. 1 (12- to 24-kg), ADG and final BW increased (linear, P = 0.006) while ADFI, G:F, Thr intake/d, and Thr intake/kg of gain increased (quadratic, P = 0.001) as Thr:Lys ratio increased (Table). Additionally, Lys intake/d increased (quadratic, P < 0.001) while Lys intake/kg of gain decreased (quadratic, P < 0.001) with increasing Thr:Lys ratio. In Exp. 2 (43- to 70-kg), ADG, G:F, final BW, Thr intake/d and Thr intake/kg of gain also increased (linear, P = 0.036) as dietary Thr:Lys increased. Moreover, Lys intake/kg of gain decreased (linear, P = 0.023) with increasing Thr:Lys. A quadratic polynomial (QP) model predicted a requirement at levels greater than 68% SID Thr:Lys for ADG from 12- to 24-kg, while a QP model suggested that maximum G:F was achieved at 61.8% SID Thr:Lys (Exp. 1). From 43- to 70-kg, QP models suggested maximum ADG and G:F were achieved at levels greater than 68% SID Thr:Lys (Exp. 2). However, similar fitting BLL models predicted no further improvement to G:F and ADG beyond 65 and 67% SID Thr:Lys, respectively. In summary, these results suggest the optimal SID Thr:Lys for 12- to 24-kg pigs is 61.8% for feed efficiency and greater than 68% for ADG. From 43- to 70-kg, the requirement was predicted at or above 65 and 67% SID Thr:Lys for G:F and ADG, respectively. [ABSTRACT FROM AUTHOR]

The objective of this study was to evaluate growth performance and economic return of PIC 800 × Camborough pigs fed increasing SID Lys from approximately 12- to 136-kg. Pens of pigs were blocked by body weight (BW) and randomly assigned to 1 of 5 dietary treatments in a randomized complete block design with 26 pigs per pen and 16 pens per treatment. Pens were provided 1 of 5 dietary treatments with increasing SID Lys at 85, 93, 100, 107, and 115% of current (2021) PIC recommendations within 6 dietary phases as follows: phase 1 (1.09, 1.19, 1.28, 1.36, and 1.47%), phase 2 (0.97, 1.06, 1.14, 1.22, and 1.32%), phase 3 (0.87, 0.95, 1.02, 1.09, and 1.17%), phase 4 (0.75, 0.82, 0.88, 0.94, and 1.01%), phase 5 (0.66, 0.72, 0.77, 0.82, and 0.89%), and phase 6 (0.59, 0.64, 0.69, 0.74, and 0.79%). Two corn-soybean meal-based diets containing low and high Lys were blended to achieve target SID Lys levels for each treatment diet within phase. Overall (d 0 to 143), increasing SID Lys improved (linear, P = 0.007) ADG and G:F, but did not impact ADFI (P > 0.10; Table). A tendency (linear, P = 0.067) for heavier hot carcass weights (HCW) was observed in pigs fed increasing SID Lys. However, there was no evidence for differences (P > 0.10) in carcass yield, backfat depth, loin depth, or carcass lean percentage across treatments. The linear (LM) model served as the best fit for both growth and economic parameters. The LM model predicted maximum ADG and G:F at levels greater than 115% of PIC's current recommendations. However, for income over feed cost (IOFC), the LM model predicted maximum profitability at or below 85% of the current Lys recommendations of PIC. In conclusion, the optimal SID Lys level for PIC 800 × Camborough pigs from 12- to 136-kg differed upon response criteria, with growth performance maximized at levels at or above 115% of the recommendation for SID Lys by PIC; however, maximal economic returns were observed at or below 85% of PIC's current SID Lys recommendations. [ABSTRACT FROM AUTHOR]

Mycoplasma hyopneumoniae (M. hyopneumoniae) is the aetiologic agent of enzootic pneumonia in swine, a prevalent chronic respiratory disease worldwide. Mycoplasma hyopneumoniae is a small, self‐replicating microorganism that possesses several characteristics allowing for limited biosynthetic abilities, resulting in the fastidious, host‐specific growth and unique pathogenic properties of this microorganism. Variation across several isolates of M. hyopneumoniae has been described at antigenic, proteomic, transcriptomic, pathogenic and genomic levels. The microorganism possesses a minimal number of genes that regulate the transcription process. Post‐translational modifications (PTM) occur frequently in a wide range of functional proteins. The PTM by which M. hyopneumoniae regulates its surface topography could play key roles in cell adhesion, evasion and/or modulation of the host immune system. The clinical outcome of M. hyopneumoniae infections is determined by different factors, such as housing conditions, management practices, co‐infections and also by virulence differences among M. hyopneumoniae isolates. Factors contributing to adherence and colonization as well as the capacity to modulate inflammatory and immune responses might be crucial. Different components of the cell membrane (i.e. proteins, glycoproteins and lipoproteins) may serve as adhesins and/or be toxic for the respiratory tract cells. Mechanisms leading to virulence are complex and more research is needed to identify markers for virulence. The utilization of typing methods and complete or partial‐gene sequencing for M. hyopneumoniae characterization has increased in diagnostic laboratories as control and elimination strategies for this microorganism are attempted worldwide. A commonly employed molecular typing method for M. hyopneumoniae is Multiple‐Locus Variable number tandem repeat Analysis (MLVA). The agreement of a shared terminology and classification for the various techniques, specifically MLVA, has not been described, which makes inferences across the literature unsuitable. Therefore, molecular trends for M. hyopneumoniae have been outlined and a common terminology and classification based on Variable Number Tandem Repeats (VNTR) types has been proposed. [ABSTRACT FROM AUTHOR]

Our objective was to determine the effects of increasing standardized ileal digestible (SID) lysine (Lys) levels on growth performance and carcass characteristics of growing-finishing pigs. A total of 1,013 barrows and gilts (PIC337×Camborough, initially 29.2±0.21 kg) were used in a 112-d growth trial with 25 or 26 pigs per pen and 13 pens per treatment in a randomized complete block design. Diets were corn-soybean meal (SBM)-dried distillers grains with solubles-based, and treatments were achieved through the inclusion of SBM at the expense of corn. Diets were fed in 6 phases and formulated to be iso-caloric within each phase. Treatments consisted of: 1) Low Lys: overall dietary SID Lys levels as 87% of PIC2016 Lys requirement; 2) Medium Lys: overall dietary SID Lys levels as 97% of PIC2016 Lys requirement; 3) High Lys: overall dietary SID Lys levels as 106% of PIC2016 Lys requirement. Experimental data were analyzed using generalized linear mixed models with pen as the experimental unit. Pigs fed High or Medium Lys had greater (P< 0.01) average daily gain compared to pigs fed Low Lys. There was no evidence (P >0.10) for the difference between treatments for average daily feed intake. Pigs fed High Lys had the greatest (P< 0.01) feed efficiency (G:F) followed by Medium Lys, with pigs fed Low Lys with the lowest G:F. Pigs fed High or Medium Lys had greater (P< 0.01) hot carcass weight, loin depth, and lean percentage compared to pigs fed Low Lys. There was no evidence (P >0.10) for treatment effect on carcass yield and backfat. Pigs fed Low Lys had greater removal and mortality rate than those fed High or Medium Lys (P< 0.01). In conclusion, increasing SID Lys over PIC2016 recommendations through increasing SBM levels resulted in increased growth performance and carcass characteristics, and reduced removal and mortality rate of 29- to- 129 kg pigs. [ABSTRACT FROM AUTHOR]

The aim of this study was to assess the genetic variability of Mycoplasma hyopneumoniae within various swine production flows. Four M. hyopneumoniae positive production flows, composed of 4 production stages, were selected for this study. Laryngeal and/or bronchial swabs were collected from each production stage within a flow, for a period of 4 months up to 3 years. A multiple-locus variable-number tandem repeat analysis was performed to assess the genetic variation of M. hyopneumoniae within and across production flows through the identification of variable-number tandem repeat (VNTR) types. A maximum of 6 M. hyopneumoniae VNTR types were identified in a single flow, in which VNTR types appeared to be flow specific. An identical VNTR type was detected across several production stages for up to 3 years. In this study, minimal M. hyopneumoniae genetic variation was evidenced within and across production flows., Competing Interests: Conflict of Interest The author(s) declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Drs. Fano and Sponheim are employed by Boehringer Ingelheim Animal Health USA Inc. However, no commercial products were evaluated in this investigation. Dr. Singer has received funding from Boehringer Ingelheim Animal Health USA Inc., (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)