99 results on '"Beton O"'
Search Results
2. Influence of influenza vaccination on recurrent hospitalization in patients with heart failure
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Kaya, H., Beton, O., Acar, G., Temizhan, A., Cavusoğlu, Y., Guray, U., Zoghi, M., Ural, D., Ekmekci, A., Gungor, H., Sari, I., Oguz, D., Yucel, H., Zorlu, A., Yilmaz, M. B., and TREAT-HF Investigators
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- 2017
- Full Text
- View/download PDF
3. Association between Neutrophil/lymphocyte ratio and suitable shocks in heart failure patients with implantable cardiac defibrillator: P280
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Yucel, H, Beton, O, Zorlu, A, Dogdu, O, Turgut, O O, and Yilmaz, M B
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- 2014
4. Comparison of outcome in systolic heart failure patients using ivabradine, digoxin or neither of them: a real life study
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Ural, D., Mutluer, F. O., Kaya, H., Beton, O., Cavusoglu, Y., Temizhan, A., Guvenc, T. S., Gungor, H., Ege, M. Refiker, Zoghi, M., Karauzum, K., Altay, H., MEHMET BIRHAN YILMAZ, [Ural, D. -- Mutluer, F. O.] Koc Univ, Istanbul, Turkey -- [Kaya, H. -- Beton, O. -- Yilmaz, M. B.] Cumhuriyet Univ, Dept Cardiol, Sivas, Turkey -- [Cavusoglu, Y.] Eskisehir Osmangazi Univ, Dept Cardiol, Eskisehir, Turkey -- [Temizhan, A.] Turkiye Yuksek Ihtisas Hosp, Ankara, Turkey -- [Guvenc, T. S.] Dr Siyami Ersek Thorac & Cardiovasc Surg Ctr, Dept Cardiol, Istanbul, Turkey -- [Gungor, H.] Adnan Menderes Univ, Aydin, Turkey -- [Ege, M. Refiker] Koru Hosp, Dept Cardiol, Ankara, Turkey -- [Zoghi, M.] Ege Univ, Dept Cardiol, Izmir, Turkey -- [Karauzum, K.] Derince Educ & Res Hosp, Dept Cardiol, Kocaeli, Turkey -- [Altay, H.] Baskent Univ, Istanbul Hosp, Istanbul, Turkey, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, and YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628
- Abstract
WOS: 000401005300138, …
- Published
- 2017
5. Coil embolization of unligated side branches in the grafted left internal mammary artery causing myocardial ischemia
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Beton, O., Yilmaz, M. B., [Beton, O. -- Yilmaz, M. B.] Cumhuriyet Univ, Cardiol, Sivas, Turkey, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, and YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628
- Abstract
Congress of the European-Society-of-Cardiology (ESC) -- AUG 27-31, 2016 -- Rome, ITALY, WOS: 000383869505276, …, European Soc Cardiol
- Published
- 2016
6. Anomalous right coronary artery: A rare cause of recurrent syncopal attacks [Anormal Sağ Koroner Arter: Rekürren Senkop Atağının Nadir Bir Nedeni]
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Beton O., Kaplanoğlu H., Bulut A., Sürer S., Kızıltepe U., and Beton, O., Cumhuriyet University, Faculty of Medicine, Department of Cardiology, Heart Center Hospital, Sivas, Turkey -- Kaplanoğlu, H., Department of Radiology, Diskapi Yildirim Beyazit Research and Training Hospital, Ankara, Turkey -- Bulut, A., Department of Cardiovasculer Surgery, Diskapi Yildirim Beyazit Research and Training Hospital, Ankara, Turkey -- Sürer, S., Department of Cardiovasculer Surgery, Diskapi Yildirim Beyazit Research and Training Hospital, Ankara, Turkey -- Kızıltepe, U., Department of Cardiovasculer Surgery, Diskapi Yildirim Beyazit Research and Training Hospital, Ankara, Turkey
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Coronary Artery Anomaly ,Right Coronary Artery ,Interarterial Course - Abstract
Derman Medical Publishing, Anomalous origin of the coronary artery is a rare anomaly and does not gener-ally lead to myocardial infarction and ventricular tachycardia. We report an un-common case of anomalous origin of the right coronary artery originating from the left sinus of Valsalva with ventricular tachycardia and myocardial ischemia. A 42-year-old male was transferred from an external facility due to syncope and documented episodes of ventricular tachycardia preceding syncope. MPS showed small ischemic area in the inferior wall. Coronary CT angiography confirmed that RCA was originating from the left coronary aortic sinus with a separate ostium from the LMCA and coursing between the aorta and the pulmonary trunk. After consulting with cardiothoracic surgeons, the decision to perform corrective sur-gery was made. A successful correction surgery was performed by the surgeons, and the patient was asymptomatic after surgery. © 2016, Journal of Clinical and Analytical Medicine. All rights reserved., Kaplanoğlu, H.; Department of Radiology, Diskapi Yildirim Beyazit Training and Research HospitalTurkey; email: hatice.altnkaynak@yahoo.com.tr
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- 2016
7. A cost effective parameter for predicting the troponin elevation in patients with carbon monoxide poisoning: red cell distribution width
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Hakkı Kaya, Coskun, A., Beton, O., Kurt, R., Yildirimli, M. K., Gul, I., and [Kaya, H. -- Beton, O. -- Yildirimli, M. K. -- Gul, I.] Cumhuriyet Univ, Univ Hosp, Fac Med, Heart Ctr, Sivas, Turkey -- [Coskun, A.] Sivas Numune Hosp, Dept Emergency, Sivas, Turkey -- [Kurt, R.] Sivas Numune Hosp, Dept Cardiol, Sivas, Turkey
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Poisoning ,Red cell distribution width ,Carbon monoxide ,Troponin - Abstract
WOS: 000382460500025, PubMed ID: 27424991, OBJECTIVE: Carbon monoxide (CO) poisoning is very common worldwide. Despite the fact that CO is known to have cardiotoxic effects, as it has non-specific symptoms; cardiotoxicity could easily be overlooked, especially when troponin is not measured. The present study aimed to evaluate the association between troponin I levels and red cell distribution width (RDW) levels, which can be measured rapidly, easily, and afforda-bly in the Emergency Room (ER). PATIENTS AND METHODS: This single-center observational study included a total of 504 consecutive patients, who presented to the ER due to CO poisoning between January 2011 and June 2015. The diagnosis of CO poisoning was made according to the medical history and carboxyhemoglobin (COHb) level of >5%. Elevated troponin test levels, which measure >0.04 ng/ml for our laboratory, were accepted as positive. RESULTS: Patients (mean age 37 +/- 14) were classified into two groups: those who had positive troponin levels (38%) and those that did not. Patients with positive troponin, who were older, had longer CO exposure time and higher creatinine, COHb and RDW levels at the index admission following CO poisoning than patients with negative troponin. In a multivariate logistic regression model with forward stepwise method, age, COHb level, CO exposure time, and RDW (HR=1.681, 95% CI: 1.472-1.934, p
- Published
- 2016
8. A new marker for poor NYHA functional class in heart failure with reduced ejection fraction: C-reactive protein / lymphocyte ratio
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Beton, O. Osman and [Beton, O. Osman] Cumhuriyet Univ, Cardiol, Sivas, Turkey
- Abstract
WOS: 000377107502141, …
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- 2016
9. Anatomic assessment of the left main bifurcation and dynamic bifurcation angles using computed tomography angiography
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Beton, O., Yilmaz, M. B., [Beton, O. -- Yilmaz, M. B.] Cumhuriyet Univ, Cardiol, Sivas, Turkey, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, and YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628
- Abstract
Congress of the European-Society-of-Cardiology (ESC) -- AUG 27-31, 2016 -- Rome, ITALY, WOS: 000383869505359, …, European Soc Cardiol
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- 2016
10. DOES TOPICAL APPLICATION OF TRANEXAMIC ACID DURING CARDIAC ELECTRONIC DEVICE IMPLANTATION AFFECT COAGULATION PROFILE?
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Beton, O. and [Beton, O.] Cumhuriyet Univ, Fac Med, Univ Hosp, Heart Ctr,Cardiol, Sivas Merkez, Turkey
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24th Biennial International Congress on Thrombosis / EMLTD Congress -- MAY 04-07, 2016 -- Istanbul, TURKEY, WOS: 000376766300066, …, EMLTD
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- 2016
11. MAJOR BLEEDING COMPLICATIONS DURING CARDIAC ELECTRONIC DEVICE IMPLANTATION IN PATIENTS RECEIVING ANTITHROMBOTIC THERAPY: DO LOCAL TRANEXAMIC ACID HAVE ANY PREVENTIVE ROLE?
- Author
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Beton, O. and [Beton, O.] Cumhuriyet Univ, Fac Med, Univ Hosp, Heart Ctr,Cardiol, Sivas Merkez, Turkey
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24th Biennial International Congress on Thrombosis / EMLTD Congress -- MAY 04-07, 2016 -- Istanbul, TURKEY, WOS: 000376766300078, …, EMLTD
- Published
- 2016
12. Negative effect of right ventricular systolic failure on time in therapeutic range TTR of patients with warfarin treatment
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Beton, O., Asarcikli, L. D., Efe, T., Yaman, M., Sen, T., Ipek, E. G., Kafes, H., Temizhan, A., MEHMET BIRHAN YILMAZ, [Beton, O. -- Yilmaz, M. B.] Cumhuriyet Univ, Cardiol, Sivas, Turkey -- [Asarcikli, L. D. -- Efe, T.] Diskapi Yildirim Beyazit Educ & Res Hosp, Ankara, Turkey -- [Yaman, M.] Samsun Educ & Res Hosp, Cardiol, Samsun, Turkey -- [Sen, T.] Dumlupinar Univ DPU, Kutahya, Turkey -- [Ipek, E. G.] Kayseri Educ & Res Hosp, Kayseri, Turkey -- [Kafes, H. -- Temizhan, A.] Turkiye Yuksek Ihtisas Hosp, Ankara, Turkey, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, and YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628
- Abstract
Congress of the European-Society-of-Cardiology (ESC) -- AUG 29-SEP 02, 2015 -- London, ENGLAND, WOS: 000361205104573, …, European Soc Cardiol
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- 2015
13. Effect of monitoring warfarin treatment of patients by single versus multiple physicians on time in therapeutic range (TTR) and treatment associated complications: Multicenter prospective cohort study
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Asarcikli, L. Dinc, Beton, O., Sen, T., Ipek, E. Gucuk, Kafes, H., Temizhan, A., MEHMET BIRHAN YILMAZ, and [Asarcikli, L. Dinc -- Beton, O.] Diskapi Yildirim Beyazit Educ & Res Hosp, Cardiol, Ankara, Turkey -- [Sen, T.] Dumlupinar Univ DPU, Cardiol, Kutahya, Turkey -- [Ipek, E. Gucuk] Kayseri Educ & Res Hosp, Kayseri, Turkey -- [Kafes, H. -- Temizhan, A.] Ankara Turkiye Yuksek Ihtisas Hosp, Dept Cardiol, Ankara, Turkey -- [Yilmaz, B.] Cumhuriyet Univ, Cardiol, Sivas, Turkey
- Abstract
Congress of the European-Society-of-Cardiology (ESC) -- AUG 29-SEP 02, 2015 -- -- London, ENGLAND, WOS: 000361205107159, …, European Soc Cardiol
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- 2015
14. Which coronary lesions are more prone to cause acute myocardial infarction? [Quais lesões coronarianas são mais propensas a causar infarto agudo do miocárdio?]
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Sen T., Astarcioglu M.A., Beton O., Asarcikli L.D., and Kilit C.
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Rupture ,Myocardial infarction ,Collateral circulation ,Coronary restenosis ,Atherosclerotic ,Plaque - Abstract
Background: According to common belief, most myocardial infarctions (MIs) are due to the rupture of nonsevere, vulnerable plaques with < 70% obstruction. Data from recent trials challenge this belief, suggesting that the risk of coronary occlusion is, in fact, much higher after severe stenosis. The aim of this study was to investigate whether or not acute ST-elevation MIs result from high-grade stenoses by evaluating the presence of coronary collateral circulation (CCC). Methods: We retrospectively included 207 consecutive patients who had undergone primary percutaneous coronary intervention for acute ST-elevation MI. Collateral blood flow distal to the culprit lesion was assessed by two investigators using the Rentrop scoring system. Results: Out of the 207 patients included in the study, 153 (73.9%) had coronary collateral vessels (Rentrop 1–3). The Rentrop scores were 0, 1, 2, and 3 in 54 (26.1%), 50 (24.2%), 51 (24.6%), and 52 (25.1%) patients, respectively. Triglycerides, mean platelet volume (MPV), white cell (WBC) count, and neutrophil count were significantly lower in the group with good collateral vessels (p = 0.013, p = 0.002, p = 0.003, and p = 0.021, respectively). Conclusion: More than 70% of the patients with acute MI had CCC with Rentrop scores of 1–3 during primary coronary angiography. This shows that most cases of acute MI in our study originated from underlying high-grade stenoses, challenging the common believe. Higher serum triglycerides levels, greater MPV, and increased WBC and neutrophil counts were independently associated with impaired development of collateral vessels. © 2017, Arquivos Brasileiros de Cardiologia. All rights reserved.
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- 2017
15. Social perspectives of heart failure: flu vaccine or not?
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Beton, O., Yucel, H., Ekmekci, A., Bayir, P. Turker, Eraslan, S., Aslan, S., Yuksel, U. C., Temizhan, A., Ural, D., MEHMET BIRHAN YILMAZ, [Beton, O. -- Yucel, H. -- Yilmaz, Mbmehmet Birhan] Cumhuriyet Univ, Sivas, Turkey -- [Ekmekci, A.] Dr Siyami Ersek Thorac & Cardiovasc Surg Ctr, Istanbul, Turkey -- [Bayir, P. Turker] Ankara Numune Hosp, Ankara, Turkey -- [Eraslan, S.] Eskisehir Osmangazi Univ, Eskisehir, Turkey -- [Aslan, S.] Istanbul Univ, Cardiol Inst, Istanbul, Turkey -- [Yuksel, U. C.] Gulhane Mil Med Acad & Fac, Ankara, Turkey -- [Temizhan, A.] Turkiye Yuksek Ihtisas Hosp, Ankara, Turkey -- [Ural, D.] Kocaeli Univ, Kocaeli, Turkey, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, and YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628
- Abstract
WOS: 000335966801274, …
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- 2014
16. Association between Neutrophil/lymphocyte ratio and suitable shocks in heart failure patients with implantable cardiac defibrillator
- Author
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Yucel, H., Beton, O., Zorlu, A., Dogdu, O., Turgut, O. O., MEHMET BIRHAN YILMAZ, [Yucel, H. -- Beton, O. -- Zorlu, A. -- Turgut, O. O. -- Yilmaz, M. B.] Cumhuriyet Univ, Sivas, Turkey -- [Dogdu, O.] Firat Univ, TR-23169 Elazig, Turkey, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, and Turgut, Okan -- 0000-0002-6847-3029
- Abstract
WOS: 000335966800176, …
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- 2014
17. Red cell distribution width predicts length of stay in patients with acutely decompensated heart failure
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MEHMET BIRHAN YILMAZ, Beton, O., Yucel, H., Gunes, H., Uslu, A. U., Zorlu, A., [Yilmaz, M. B. -- Beton, O. -- Yucel, H. -- Gunes, H. -- Uslu, A. U. -- Zorlu, A.] Cumhuriyet Univ, Sivas, Turkey, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, and YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628
- Abstract
Annual Meeting of the European-Society-of-Cardiology (ESC) -- AUG 30-SEP 03, 2014 -- Barcelona, SPAIN, WOS: 000343001304751, …, European Soc Cardiol
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- 2014
18. Supplementary Material for: Right Ventricular Dysfunction Complicates Time in Therapeutic Range in Heart Failure Patients Receiving Warfarin
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Beton, O., Asarcikli, L.D., Sen, T., Ipek, E.G., Kafes, H., Yaman, M., Efe, T.H., Kaya, H., Temizhan, A., and Yilmaz, M.B.
- Abstract
Aim: We aimed to evaluate the effect of echocardiographically demonstrated right ventricular dysfunction (RVD) on time in therapeutic range (TTR) in heart failure (HF) patients receiving warfarin therapy. Methods: A total of 893 consecutive HF patients were included and classified into 4 different subgroups: HF with preserved ejection fraction (HFpEF) without RVD (n = 373), HF with reduced EF (HFrEF) without RVD (n = 215), HFpEF with RVD (n = 106) and HFrEF with RVD (n = 199). Groups were compared according to baseline, demographic and clinical data and the characteristics of warfarin therapy. Results: Presence of RVD yielded lower median TTR values both in HFpEF and HFrEF patients. RVD, current smoking, New York Heart Association functional class III/IV, hypertension, diabetes mellitus, pulmonary disease, prior transient ischemic attack or stroke, chronic kidney disease (CKD) stage 4/5 and CKD stage 3 were found to be independent predictors of poor anticoagulation control in multivariate logistic regression analysis. Conclusions: The present study demonstrated that presence of RVD in HF increases the risk for poor anticoagulation.
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- 2016
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19. The value of exercise SPET for the detection of coronary artery steal syndrome secondary to unligated major side branch of left internal mammary artery
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Beton, O., Kaya, H., Kandemir, O., Alibazoglu, B., Alibazoglu, H., Karabey, E., Turgut, O. O., MEHMET BIRHAN YILMAZ, [Beton, Osman -- Kaya, Hakk -- Karabey, Ercan -- Turgut, Okan Onur -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Ctr Heart, Dept Cardiol, PC 58140, Sivas, Turkey -- [Kandem, Ozan] Numune State Hosp, Dept Nucl Med, Sivas, Turkey -- [Alibazoglu, Buket -- Alibazoglu, Haluk] CardioCheck Nucl Imaging Ctr, Ankara, Turkey -- [Alibazoglu, Haluk] Cleveland Clin, Imaging Inst, Dept Nucl Med, Abu Dhabi, U Arab Emirates, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, and YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628
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Coronary by-pass surgery ,Left internal mammary artery ,Exercise perfusion scan ,Unligated side branch ,Anterior wall ischemia - Abstract
WOS: 000392715800004, PubMed ID: 27824958, Objective: The clinical significance of unligated major left internal mammary artery (LIMA)-side branches (SB) remains controversial in patients with previous coronary artery bypass graft (CABG) surgery. The aim of this study was to investigate the clinical significance of unligated major LIMA-SB by using exercise myocardial perfusion imaging (MPI) with single-photon emission tomography. Subjects and Methods: We conducted a retrospective analysis of 2819 consecutive patients who underwent diagnostic angiography. There were 407 CABG patients with LIMA graft. The demographic, laboratory, pre-angiographic stress test and angiographic data of these patients were collected. A subgroup of patients with unligated major LIMA-SB who were referred to angiography with the diagnosis of stable angina pectoris and positive exercise MPI was identified and divided into two groups for comparison: anterior wall vs non-anterior wall ischemia groups. Results: Among 407 patients with LIMA graft, 112 (27.5%) patients were found to have unligated major LIMA-SB. In a subgroup of patients (n=45) with positive exercise MPI and patent LAD-LIMA system with unligated major LIMA-SB, the median values of diameter and length of unligated major LIMA-SB were statistically higher in anterior wall ischemia group (n=24) compared to non-anterior wall ischemia group (1.8mm vs 0.6mm, P= 11.0cm and a diameter of > 1.3cm had 95.8% of sensitivity and 100% of specificity for predicting anterior wall ischemia on exercise MPI. In patients with anterior wall ischemia, summed stress score and summed difference score were improved after percutaneous coil embolization of large unligated major LIMA-SB with 11.0cm length and > 1.3mm diameter. Conclusion: Large unligated major LIMA-SB with 11.0cm length and > 1.3mm diameter seems to be a potential source of ischemia in CABG patients. We suggest that exercise MPI might be a first option noninvasive test in evaluating the clinical significance of unligated major LIMA-SB and the effectiveness of embolization therapy.
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- 2016
20. Anatomic assessment of the left main bifurcation and dynamic bifurcation angles using computed tomography angiography
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Beton, O., primary, Kaplanoglu, H., additional, Hekimoglu, B., additional, and Yilmaz, M. B., additional
- Published
- 2017
- Full Text
- View/download PDF
21. Management of atrial fibrillation in the Emergency Department: current approach and future expectations
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Russo, V., Navarin, S., Zampini, G., Magrini, L., Mann, C., Muiesan, M. L., Caterina, R., MEHMET BIRHAN YILMAZ, Beton, O., Monzani, V., Kubica, J., Mueller, C., Di Somma, S., Great Network, [Russo, V. -- Navarin, S. -- Zampini, G. -- Magrini, L. -- Di Somma, S.] Univ Roma La Sapienza, Sch Med & Psychol, St Andrea Hosp, Dept Emergency Med, I-00185 Rome, Italy -- [Mann, C.] Taunton & Somerset Hosp, Sch Emergency Med, London, England -- [Muiesan, M. L.] Univ Brescia, Div Internal & Emergency Med, Brescia, Italy -- [De Caterina, R.] Univ G DAnnunzio, Inst Cardiol & Ctr Excellence Aging, Chieti, Italy -- [Yilmaz, M. B.] Cumhuriyet Univ, Dept Cardiol, Sivas, Turkey -- [Beton, O.] Sivas State Hosp, Cardiol Clin, Sivas, Turkey -- [Monzani, V.] Maggiore Policlin Hosp, Emergency Med Unit, Fdn IRCCS Ca Granda, Milan, Italy -- [Kubica, J.] Nicolaus Copernicus Univ, Dept Cardiol & Internal Med, Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland -- [Mueller, C.] Univ Basel Hosp, Div Cardiol, CH-4031 Basel, Switzerland, De Caterina, Raffaele -- 0000-0003-1637-574X, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, and Kubica, Jacek -- 0000-0001-8250-754X
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Antithrombotic therapy ,Rhytm and rate control ,Emergency Service ,Time Factors ,Atrial fibrillation ,Cardioversion ,Algorithms ,Atrial Fibrillation ,Cardiology Service, Hospital ,Emergency Service, Hospital ,Forecasting ,Humans ,Practice Guidelines as Topic ,Predictive Value of Tests ,Treatment Outcome ,Hospital ,Cardiology Service - Abstract
WOS: 000331435600002, PubMed ID: 24338454, Atrial fibrillation (AF) is the most common cardiac dysrhythmia and occurs in 3.3%-10% of emergency admissions. It is frequently quoted for people over the age of 75, but the cases of AF in young subjects without structural heart disease are also increasing, therefore, leading to the evaluation of "lonely atrial fibrillation" as a new challenge for the clinician. The first diagnosis and treatment often occur in the emergency room and the emergency physician has therefore to evaluate the initial step towards the therapeutic decisions. Although international standard guidelines are available, AF treatment in the Emergency Department (ED) is still heterogeneous in terms of the management strategy chosen. There are two main strategies for the management of AF: rate and rhythm control. Moreover, antithrombotic treatment is pivotal in AF to prevent cardioembolic stroke and it is considered a primary objective after an accurate assessment of antithrombotic treatment risks and benefits. The introduction of innovative echocardiographic approach, directly in ED, seems to improve the management and risk stratification of patients with AF. This review aims to provide an overview about the current approach and the future expectations in the management of AF in ED. This manuscript represents a synopsis of the lectures on AF management in the ED of the Third Italian GREAT Network Congress, that was hold in Rome, 15-19 October 2012. We decided to use only the most relevant references for each contribution as suggested by each participant at this review.
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- 2013
22. Real-life use of digoxin in patients with non-valvular atrial fibrillation: data from the RAMSES study
- Author
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Biteker, M., primary, Başaran, Ö., additional, Dogan, V., additional, Beton, O., additional, Tekinalp, M., additional, Çağrı Aykan, A., additional, Kalaycıoğlu, E., additional, Bolat, I., additional, TaŞar, O., additional, Şafak, Ö., additional, Kalçık, M., additional, Yaman, M., additional, and Kırma, C., additional
- Published
- 2016
- Full Text
- View/download PDF
23. A cost effective parameter for predicting the troponin elevation in patients with carbon monoxide poisoning: red cell distribution width.
- Author
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KAYA, H., COSKUN, A., BETON, O., KURT, R., YILDIRIMLI, M.K., and GUL, I.
- Abstract
OBJECTIVE: Carbon monoxide (CO) poisoning is very common worldwide. Despite the fact that CO is known to have cardiotoxic effects, as it has non-specific symptoms; cardiotoxicity could easily be overlooked, especially when troponin is not measured. The present study aimed to evaluate the association between troponin I levels and red cell distribution width (RDW) levels, which can be measured rapidly, easily, and afforda-bly in the Emergency Room (ER). PATIENTS AND METHODS: This single-center observational study included a total of 504 consecutive patients, who presented to the ER due to CO poisoning between January 2011 and June 2015. The diagnosis of CO poisoning was made according to the medical history and carboxyhemoglobin (COHb) level of >5%. Elevated troponin test levels, which measure >0.04 ng/ml for our laboratory, were accepted as positive. RESULTS: Patients (mean age 37±14) were classified into two groups: those who had positive troponin levels (38%) and those that did not. Patients with positive troponin, who were older, had longer CO exposure time and higher creatinine, COHb and RDW levels at the index admission following CO poisoning than patients with negative troponin. In a multivariate logistic regression model with forward stepwise method, age, COHb level, CO exposure time, and RDW (HR=1.681, 95% CI: 1.472-1.934, p<0.001) remained asso-ciated with an increased risk of troponin positivity following adjustment for the variables that were statis-tically significant in the univariate analysis and correlated with RDW. CONCLUSIONS: In patients presenting to the ER with CO poisoning, RDW can be helpful for the risk stratification of tro-ponin positivity. [ABSTRACT FROM AUTHOR]
- Published
- 2016
24. Early and late aortic propagation velocity values in STEMI patients after successful primary PCI and their relationship with neutrophil to lymphocyte ratio.
- Author
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YAMAN, M., ARSLAN, U., BETON, O., PAMUKCU, H. E., and DOGDU, O.
- Abstract
OBJECTIVE: Atherosclerosis leads to increased arterial resistance through thickening and stiffening of the arterial wall, a phenomenon largely known as arterial stiffness. M-mode propagation velocity of the descending thoracic aorta, named aortic velocity propagation (AVP) is a novel method for the measurement of the aortic stiffness. We aimed to investigate the difference between early and late values of AVP after successful primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients. PATIENTS AND METHODS: A total of 103 (70 male, 67.9%) consecutive patients without a previous history of coronary artery disease, who presented with STEMI without hemodynamic compromise and underwent successful primary PCI were enrolled. Transthoracic echocardiography was performed in all patients after primary PCI at 12-24 hour in Intensive Care Unit (early measurements) and three months after the discharge during follow-up (late measurements). Doppler echocardiography, 2D and aortic M-mode propagation velocity measurements were recorded. Haematological and serum biochemical parameters of the study group were recorded. RESULTS: There were no statistically significant differences in 2D echocardiography measurements between early and late evaluations. AVP values increased during 3 months followup in all patients. Mean AVP values were 33.7± 11.6 cm/sn and 44.4±10.5 cm/sn at early and late measurements, respectively (p<0.001). There were significant correlations between differences of AVP and neutrophil-lymphocyte ratio between early and late measurements. CONCLUSIONS: We demonstrated for the first time that AVP values could improve after successful treatment in STEMI patients. The increment in AVP values was closely correlated with a decrement in neutrophil lymphocyte ratio. It can be postulated that AVP has strong correlations with the inflammatory markers. [ABSTRACT FROM AUTHOR]
- Published
- 2016
25. PP-246 TREATMENT OF STEAL SYNDROME AFTER CORONARY BY PASS SURGERY BY COIL EMBOLISATION
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Karakuzu, A., primary and Beton, O., additional
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- 2012
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26. PP-243 CASE REPORT: TREATMENT OF INTERVENTRICULAR SEPTAL MASSIVE BLEEDING FOLLOWING CORONARY INTERVENTION
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Karakuzu, A., primary and Beton, O., additional
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- 2012
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- View/download PDF
27. Refractory vasovagal syncope despite orthostatic training
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Beton, O., Acar, B., Asarcikli, L. D., Yilmaz, N., Kaya, H., Kurt, R., Guray, Y., Yilmaz, M. B., [Beton, O. -- Kaya, H. -- Yilmaz, M. B.] Cumhuriyet Univ, Cardiol, Sivas, Turkey -- [Acar, B. -- Guray, Y.] Turkiye Yuksek Ihtisas Hosp, Ankara, Turkey -- [Asarcikli, L. D.] Diskapi Yildirim Beyazit Educ & Res Hosp, Cardiol, Ankara, Turkey -- [Yilmaz, N.] Cumhuriyet Univ, Psychiat, Sivas, Turkey -- [Kurt, R.] Sivas State Hosp, Cardiol, Sivas, Turkey, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, and YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628
- Abstract
Congress of the European-Society-of-Cardiology (ESC) -- AUG 27-31, 2016 -- Rome, ITALY, WOS: 000383869506062, …, European Soc Cardiol
28. Plasma osmolality predicts mortality in patients with heart failure with reduced ejection fraction
- Author
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MEHMET BIRHAN YILMAZ, Ekmekci, A., Gunes, H., Uslu, A. U., Beton, O., Yucel, H., Oguz, D., Eren, M., [Yilmaz, MBMehmet Birhan -- Gunes, H. -- Uslu, A. U. -- Beton, O. -- Yucel, H.] Cumhuriyet Univ, Sivas, Turkey -- [Ekmekci, A. -- Eren, M.] Dr Siyami Ersek Thorac & Cardiovasc Surg Ctr, Istanbul, Turkey -- [Oguz, D.] Baskent Univ, Istanbul Hosp, Istanbul, Turkey, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, and YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628
- Abstract
WOS: 000335966801031, …
29. GUIDELINE ADHERENCE OF NON-VITAMIN K ANTAGONIST ORAL ANTICOAGULANT THERAPY: RESULTS FROM RAMSES STUDY
- Author
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Basaran, O., Dogan, V., Biteker, M., Beton, O., Tekinalp, M., Bolat, I., Tasar, O., Kalcik, M., Kalaycioglu, E., Aykan, A. C., Safak, O., Yaman, M., Inci, S., Altintas, B., Kalkan, S., Karadeniz, F., Altun, I., Soylu, M. O., [Basaran, O.] Mugla Sitki Kocman Univ, Cardiol, Mugla, Turkey -- [Dogan, V. -- Biteker, M. -- Altun, I. -- Soylu, M. O.] Mugla Sitki Kocman Univ, Mugla, Turkey -- [Beton, O.] Cumhuriyet Univ, Sivas, Turkey -- [Tekinalp, M.] Kahramanmaras Necip Fazil State Hosp, Kahramanmaras, Turkey -- [Bolat, I.] Fethiye State Hosp, Mugla, Turkey -- [Tasar, O.] Elazig Educ & Res Hosp, Elazig, Turkey -- [Kalcik, M.] Iskilip Atif Hoca State Hosp, Corum, Turkey -- [Kalaycioglu, E. -- Aykan, A. C.] Trabzon Ahi Evren Educ & Res Hosp, Trabzon, Turkey -- [Safak, O.] Burdur State Hosp, Burdur, Turkey -- [Yaman, M.] Samsun Educ & Res Hosp, Samsun, Turkey -- [Inci, S.] Aksaray State Hosp, Aksaray, Turkey -- [Altintas, B.] Diyarbakir Gazi Yasargil Educ & Res Hosp, Diyarbakir, Turkey -- [Kalkan, S.] Gonen State Hosp, Balikesir, Turkey -- [Karadeniz, F.] Sanliurfa Balikligol State Hosp, Sanliurfa, Turkey, and BASARAN, OZCAN -- 0000-0002-6384-6455
- Abstract
24th Biennial International Congress on Thrombosis / EMLTD Congress -- MAY 04-07, 2016 -- Istanbul, TURKEY, WOS: 000376766300020, …, EMLTD
30. Early and late aortic propagation velocity values in STEMI patients after successful primary PCI and their relationship with neutrophil to lymphocyte ratio
- Author
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Yaman M, Uğur Arslan, Beton O, He, Pamukcu, and Dogdu O
- Subjects
Adult ,Male ,Time Factors ,Neutrophils ,Myocardial Infarction ,Aorta, Thoracic ,Middle Aged ,Leukocyte Count ,Percutaneous Coronary Intervention ,Treatment Outcome ,Vascular Stiffness ,Humans ,Female ,Lymphocytes ,Blood Flow Velocity ,Aged - Abstract
Atherosclerosis leads to increased arterial resistance through thickening and stiffening of the arterial wall, a phenomenon largely known as arterial stiffness. M-mode propagation velocity of the descending thoracic aorta, named aortic velocity propagation (AVP) is a novel method for the measurement of the aortic stiffness. We aimed to investigate the difference between early and late values of AVP after successful primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients.A total of 103 (70 male, 67.9%) consecutive patients without a previous history of coronary artery disease, who presented with STEMI without hemodynamic compromise and underwent successful primary PCI were enrolled. Transthoracic echocardiography was performed in all patients after primary PCI at 12-24 hour in Intensive Care Unit (early measurements) and three months after the discharge during follow-up (late measurements). Doppler echocardiography, 2D and aortic M-mode propagation velocity measurements were recorded. Haematological and serum biochemical parameters of the study group were recorded.There were no statistically significant differences in 2D echocardiography measurements between early and late evaluations. AVP values increased during 3 months follow-up in all patients. Mean AVP values were 33.7± 11.6 cm/sn and 44.4±10.5 cm/sn at early and late measurements, respectively (p0.001). There were significant correlations between differences of AVP and neutrophil-lymphocyte ratio between early and late measurements.We demonstrated for the first time that AVP values could improve after successful treatment in STEMI patients. The increment in AVP values was closely correlated with a decrement in neutrophil lymphocyte ratio. It can be postulated that AVP has strong correlations with the inflammatory markers.
31. Anatomic assessment of the left main bifurcation and dynamic bifurcation angles using computed tomography angiography
- Author
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Beton, O. and MEHMET BIRHAN YILMAZ
32. Anatomic assessment of the left main bifurcation and dynamic bifurcation angles using computed tomography angiography
- Author
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Hatice Kaplanoglu, Mehmet Yilmaz, Osman Beton, Baki Hekimoglu, [Beton, O. -- Yilmaz, M. B.] Cumhuriyet Univ, Univ Hosp, Dept Cardiol, Heart Ctr, TR-58140 Sivas, Turkey -- [Kaplanoglu, H. -- Hekimoglu, B.] Diskapi Yildirim Beyazit Res & Training Hosp, Dept Radiol, Ankara, Turkey, YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628, and YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628
- Subjects
Male ,left main coronary artery ,medicine.medical_specialty ,Histology ,Computed Tomography Angiography ,Left circumflex artery ,Imaging, Three-Dimensional ,Internal medicine ,medicine.artery ,medicine ,Humans ,In patient ,Computed tomography angiography ,medicine.diagnostic_test ,business.industry ,Coronary computed tomography angiography ,Mean age ,Middle Aged ,Coronary Vessels ,anatomic dimensions and bifurcations angles ,medicine.anatomical_structure ,Right coronary artery ,Cardiology ,Female ,coronary computed tomography angiography ,Anatomy ,business ,Artery - Abstract
WOS: 000405499200008, PubMed ID: 27714730, Background: An understanding of the left main coronary artery (LMCA) anatomy is important for accurate diagnosis and therapy. We aimed to investigate LMCA anatomy via 128-multisliced coronary computed-tomography-angiography (CCTA) in patients with normal LMCA. Materials and methods: A total of 201 CCTA studies were included in this study. Anatomical features of LMCA including cross-sectional areas of the LMCA ostial, LMCA distal, left anterior descending artery (LAD) ostial and left circumflex artery (LCX) ostial, and degree of tapering and LMCA bifurcation angles (BA) in the form of LMCA-LCX BA, LMCA-LAD BA, LAD-LCX BA at end-diastole and end-systole. Results: The mean age was 55 +/- 11; 55.7% of patients were males. Right coronary artery was dominant in 173 (86.1%) patients. Mean LMCA length was 10.0 +/- 4.5 mm. The mean values of LMCA ostial, LMCA distal, LAD ostial and LCX ostial areas were 18.2 +/- 5.1 mm2, 13.2 +/- 4.0 mm2, 9.0 +/- 3.2 mm(2) and 7.6 +/- +/- 2.8 mm(2), respectively. LMCA ostial-distal area, LMCA distal-LAD ostial area and LMCA distal-LCX ostial area ratios were = 1.44 -< 1.69 in 47 (23.4%), 53 (26.4%), 47 (23.4%) patients, respectively, and were = 1.69 -< 1.96 in 19 (9.5%), 24 (11.9%), 40 (19.9%) patients respectively. Systolic motion modifies LMCA BAs; systolic motion begets an increment of LMCA-LAD angle in 72.6% of patients and decrement of LAD-LCX angle in 75.6% of patients. Patients with T-shaped LAD-LCX BA was shown to have significantly longer LMCA, larger LAD ostial area, larger LCX ostial area and higher diastolic-to-systolic range (DSR) of LAD-LCX BA compared to patients with Y-shaped LAD-LCX BA. Conclusions: LMCA with T-shaped distal BA was found to have significantly longer LMCA, larger LAD ostial area, larger LCX ostial area and higher DSR of distal BA compared to patients with Y-shaped distal BA. These findings may provide useful information for LMCA bifurcation stenting or designing dedicated stents for LMCA.
- Published
- 2017
- Full Text
- View/download PDF
33. Real-life use of digoxin in patients with non-valvular atrial fibrillation: data from the RAMSES study
- Author
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Mehmet Yaman, Macit Kalçık, Onur Taşar, Özcan Başaran, Osman Beton, Ezgi Kalaycıoğlu, Ismail Bolat, Volkan Doğan, A. Çağrı Aykan, Murat Biteker, Özgen Şafak, Mehmet Tekinalp, Cevat Kirma, [Biteker, M. -- Basaran, O. -- Dogan, V.] Mugla Sitki Kocman Univ, Dept Cardiol, Fac Med, Mugla, Turkey -- [Beton, O.] Sivas Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey -- [Tekinalp, M.] Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- [Aykan, A. Cagri -- Kalaycioglu, E.] Trabzon Ahi Evren Chest Cardiovasc Surg Educ & Re, Dept Cardiol, Trabzon, Turkey -- [Bolat, I.] Fethiye State Hosp, Dept Cardiol, Mugla, Turkey -- [TaSar, O.] Elazig Educ & Res Hosp, Dept Cardiol, Elazig, Turkey -- [Safak, O.] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Kalcik, M.] Iskilip Atif Hoca State Hosp, Dept Cardiol, Iskilip, Turkey -- [Yaman, M.] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Kirma, C.] Kartal Kosuyolu Heart Educ & Res Hosp, Istanbul, Turkey, and BASARAN, OZCAN -- 0000-0002-6384-6455
- Subjects
Male ,medicine.medical_specialty ,Digoxin ,Turkey ,Heart Ventricles ,Population ,Comorbidity ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,Atrial Fibrillation ,Medicine ,Humans ,Pharmacology (medical) ,Medical history ,atrial fibrillation ,cardiovascular diseases ,030212 general & internal medicine ,Prospective Studies ,Medical prescription ,education ,Aged ,Pharmacology ,Heart Failure ,education.field_of_study ,business.industry ,Atrial fibrillation ,digoxin ,medicine.disease ,Stroke ,congestive heart failure ,Heart failure ,Cardiology ,Female ,business ,medicine.drug - Abstract
WOS: 000386930500018, PubMed ID: 27671101, What is known and objectiveAlthough inappropriate use of digoxin has been described in various populations, a real-world evaluation of patterns of digoxin prescription has not been well studied in patients with atrial fibrillation (AF). The aim of this study was to identify prevalence, indications and appropriateness of digoxin use in the general population of patients with non-valvular AF (NVAF) in Turkey. MethodsWe included and classified patients from the RAMSES (ReAl-life Multicentre Survey Evaluating Stroke prevention strategies in Turkey) study, a prospective registry including 6273 patients with NVAF, on the basis of digoxin use. After excluding the data of 73 patients whose medical history about digoxin use or left ventricle function was absent, 6200 patients were included for the final analysis. Digoxin use was considered inappropriate if patients did not have left ventricular systolic dysfunction or symptomatic heart failure (HF). Results and discussionDigoxin was used in 1274 (20.5%) patients. Patients treated with digoxin were older (71.4 9.8 years vs. 69.2 +/- 10.9 years, P < 0.001), more likely to be female (58.8% vs. 55.9%, P = 0.019) and had more common comorbidities such as HF (40.2% vs. 17.4%), diabetes (26.4% vs. 21.1%), coronary artery disease (35.3 vs. 27.6%) and persistent/permanent AF (93.4% vs. 78.4%; P < 0.001 for each comparison). Of the 1274 patients, the indication of digoxin use was considered inappropriate in 762 (59.8%). What is new and conclusionOur findings show that nearly one-fifth of the patients with NVAF were on digoxin therapy and nearly 60% of these patients were receiving digoxin with inappropriate indications in a real-world setting.
- Published
- 2016
34. Suboptimal use of non-vitamin K antagonist oral anticoagulants: Results from the RAMSES study
- Author
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Basaran, Ozcan, Dogan, Volkan, Beton, Osman, Tekinalp, Mehmet, Aykan, Ahmet Cagri, Kalaycioglu, Ezgi, Bolat, Ismail, Tasar, Onur, Safak, Ozgen, Kalcik, Macit, Yaman, Mehmet, Inci, Sinan, Altintas, Bernas, Kalkan, Sedat, Kirma, Cevat, Biteker, Murat, Karadeniz, Fatma Ozpamuk, Tekkesin, Ahmet Ilker, Cakilli, Yasin, Turkkan, Ceyhan, Hamidi, Mehmet, Demir, Vahit, Gursoy, Mustafa Ozan, Ozturk, Mujgan Tek, Aksan, Gokhan, Seyis, Sabri, Balli, Mehmet, Alici, Mehmet Hayri, Bozyel, Serdar, Altun, Ibrahim, Calik, Feyza, Karaca, Oguz, Helvaci, Fusun, Akay, Kadriye, Canga, Yigit, Celebi, Savas, Altuntas, Emine, Ayturk, Mehmet, Gunes, Haci Murat, Bezgin, Tahir, Aksakal, Aytekin, Cakal, Beytullah, Colak, Ayse, Kaplan, Ozgur, Tatlisu, Adem, Gozubuyuk, Gokhan, Demirelli, Selami, Kaya, Adnan, Rencuzogullari, Ibrahim, Bayram, Zubeyde, Simsek, Zeki, Civan, Murat, Batgharel, Ulaankhu, Ata, Ali Ekber, Gol, Gokhan, Mert, Gurbet Ozge, Mert, Kadir Ugur, Degirmencioglu, Aleks, Candan, Ozkan, Celebi, Ozlem Ozcan, Dogan, Cem, Yavuz, Fethi, Ulucan, Seref, Arisoy, Arif, Sahin, Bingul Dilekci, Ermis, Emrah, Gokaslan, Serkan, Pektas, Idris, Tanindi, Asli, Tekin, Kamuran, Sancar, Kadriye Memic, Cekic, Edip Guvenc, Basaran, Nesrin Filiz, Acibadem University Dspace, Basaran, Ö., Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, 48000, Turkey -- Dogan, V., Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, 48000, Turkey -- Beton, O., Department of Cardiology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey -- Tekinalp, M., Department of Cardiology, Kahramanmaras Necip Fazl State Hospital, Kahramanmaras, Turkey -- Aykan, A.C., Department of Cardiology, Trabzon Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey -- Kalaycioglu, E., Department of Cardiology, Trabzon Ahi Evren Chest Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey -- Bolat, I., Department of Cardiology, Fethiye State Hospital, Fethiye, Turkey -- Tasar, O., Department of Cardiology, Elazg Education and Research Hospital, Elazg, Turkey -- Safak, Ö., Department of Cardiology, Burdur State Hospital, Burdur, Turkey -- Kalcik, M., Department of Cardiology, Skilip Atf Hoca State Hospital, Corum, Turkey -- Yaman, M., Department of Cardiology, Samsun Education and Research Hospital, Samsun, Turkey -- Nci, S., Department of Cardiology, Aksaray State Hospital, Aksaray, Turkey -- Altintas, B., Department of Cardiology, Diyarbakr Gazi Yasargil Education and Research Hospital, Diyarbakr, Turkey -- Kalkan, S., Department of Cardiology, Gönen State Hospital, Gönen, Turkey -- Kirma, C., Kartal Kosuyolu Heart Education and Research Hospital, Kartal, Istanbul, Turkey -- Biteker, M., Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University, Mugla, 48000, Turkey, MÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Başaran, Özcan, Doğan, Volkan, [Karadeniz, Fatma Ozpamuk] Sanliurfa Balikligol State Hosp, Dept Cardiol, Merkez Sanliurfa, Turkey -- [Tekkesin, Ahmet Ilker -- Turkkan, Ceyhan -- Cakal, Beytullah] Siyami Ersek Heart Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Cakilli, Yasin] Tuzla State Hosp, Dept Cardiol, Tuzla Istanbul, Turkey -- [Hamidi, Mehmet] Bandirma State Hosp, Dept Cardiol, Balikesir, Turkey -- [Demir, Vahit] Yozgat State Hosp, Dept Cardiol, Yozgat, Turkey -- [Gursoy, Mustafa Ozan] Gaziemir State Hosp, Dept Cardiol, Gaziemir, Turkey -- [Ozturk, Mujgan Tek -- Ayturk, Mehmet] Ankara Kecioren Educ & Res Hosp, Dept Cardiol, Ankara, Turkey -- [Aksan, Gokhan -- Helvaci, Fusun] Sisli Hamidiye Etfal Educ & Res Hosp, Dept Cardiol, Sisli, Turkey -- [Seyis, Sabri] Mersin Private Dogus Hosp, Dept Cardiol, Mersin, Turkey -- [Balli, Mehmet] Mersin Toros State Hosp, Dept Cardiol, Mersin, Turkey -- [Alici, Mehmet Hayri] Gaziantep 25 Aralik State Hosp, Dept Cardiol, Gaziantep, Turkey -- [Bozyel, Serdar] Kocaeli Derince Educ & Res Hosp, Dept Cardiol, Kocaeli, Turkey -- [Altun, Ibrahim -- Mert, Gurbet Ozge -- Mert, Kadir Ugur -- Sancar, Kadriye Memic] Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkey -- [Calik, Feyza] Mersin State Hosp, Dept Cardiol, Mersin, Turkey -- [Karaca, Oguz -- Gunes, Haci Murat] Istanbul Medipol Univ, Fac Med, Dept Cardiol, Istanbul, Turkey -- [Akay, Kadriye] Kocaeli State Hosp, Dept Cardiol, Kocaeli, Turkey -- [Canga, Yigit -- Bayram, Zubeyde -- Simsek, Zeki] Kartal Yavuz Selim State Hosp, Dept Cardiol, Istanbul, Turkey -- [Celebi, Savas] TOBB ETU Hosp, Dept Cardiol, Ankara, Turkey -- [Altuntas, Emine] Bingol State Hosp, Dept Cardiol, Bingol, Turkey -- [Bezgin, Tahir] Gebze Fatih State Hosp, Dept Cardiol, Gebze, Turkey -- [Aksakal, Aytekin] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Colak, Ayse] Mut State Hosp, Dept Cardiol, Mersin, Turkey -- [Kaplan, Ozgur -- Gozubuyuk, Gokhan -- Dogan, Cem] Malatya State Hosp, Dept Cardiol, Malatya, Turkey -- [Tatlisu, Adem] Sivas Numune State Hosp, Dept Cardiol, Sivas, Turkey -- [Demirelli, Selami -- Sahin, Bingul Dilekci -- Ermis, Emrah] Erzurum Bolge Educ & Res Hosp, Dept Cardiol, Erzurum, Turkey -- [Kaya, Adnan] Suruc State Hosp, Dept Cardiol, Sanliurfa, Turkey -- [Rencuzogullari, Ibrahim] Kafkas Univ, Fac Med, Dept Cardiol, Kars, Turkey -- [Civan, Murat] Istanbul Private Liv Hosp, Dept Cardiol, Istanbul, Turkey -- [Batgharel, Ulaankhu] Acibadem Private Hosp, Dept Cardiol, Istanbul, Turkey -- [Ata, Ali Ekber] Samsun Medikal Pk Hosp, Dept Cardiol, Samsun, Turkey -- [Gol, Gokhan] Sureyyapasa Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Degirmencioglu, Aleks] Istanbul Acibadem Univ, Fac Med, Dept Cardiol, Istanbul, Turkey -- [Candan, Ozkan] Usak State Hosp, Dept Cardiol, Usak, Turkey -- [Celebi, Ozlem Ozcan] Private Medicana Int Ankara Hosp, Dept Cardiol, Ankara, Turkey -- [Yavuz, Fethi] Dr Ersin Arslan State Hosp, Dept Cardiol, Gaziantep, Turkey -- [Ulucan, Seref] Mevlana Univ, Fac Med, Dept Cardiol, Konya, Turkey -- [Arisoy, Arif] Gaziosmanpasa Univ, Fac Med, Dept Cardiol, Gaziosmanpasa, Turkey -- [Gokaslan, Serkan] Istanbul Haydarpasa Numune Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- [Pektas, Idris] Mersin Univ, Fac Med, Dept Cardiol, Mersin, Turkey -- [Tanindi, Asli] Ufuk Univ, Fac Med, Dept Cardiol, Ufuk, Turkey -- [Tekin, Kamuran] Batman Bolge State Hosp, Dept Cardiol, Batman, Turkey -- [Cekic, Edip Guvenc -- Basaran, Nesrin Filiz] Mugla Sitki Kocman Univ, Fac Med, Dept Pharmacol, Mugla, Turkey -- [Basaran, Ozcan -- Dogan, Volkan -- Biteker, Murat] Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey -- [Tekinalp, Mehmet] Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- [Aykan, Ahmet Cagri -- Kalaycioglu, Ezgi] Trabzon Ahi Evren Chest Cardiovasc Surg Educ & Re, Dept Cardiol, Trabzon, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Fethiye, Turkey -- [Tasar, Onur] Elazig Educ & Res Hosp, Dept Cardiol, Elazig, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Kalcik, Macit] Iskilip Atif Hoca State Hosp, Dept Cardiol, Corum, Turkey -- [Yaman, Mehmet] Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- [Inci, Sinan] Aksaray State Hosp, Dept Cardiol, Aksaray, Turkey -- [Altintas, Bernas] Diyarbakir Gazi Yasargil Educ & Res Hosp, Dept Cardiol, Diyarbakir, Turkey -- [Kalkan, Sedat] Gonen State Hosp, Dept Cardiol, Gonen, Turkey -- [Kirma, Cevat] Kartal Kosuyolu Heart Educ & Res Hosp, Istanbul, Turkey, and BASARAN, OZCAN -- 0000-0002-6384-6455
- Subjects
Pediatrics ,Vitamin K ,Turkey ,Undertreatment ,Administration, Oral ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Risk Factors ,Atrial Fibrillation ,atrial fibrillation ,off-label use ,030212 general & internal medicine ,Prospective Studies ,Registries ,Prospective cohort study ,anticoagulation ,Stroke ,Over-Treatment ,General Medicine ,Vitamin K antagonist ,stroke ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,Practice Guidelines as Topic ,Guideline Adherence ,InformationSystems_MISCELLANEOUS ,medicine.drug ,Research Article ,medicine.medical_specialty ,medicine.drug_class ,Renal function ,Observational Study ,Subgroup analysis ,Hemorrhage ,Dabigatran ,03 medical and health sciences ,Anticoagulation ,medicine ,Humans ,Rivaroxaban ,undertreatment ,business.industry ,ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS ,Anticoagulants ,Guideline ,Off-Label Use ,medicine.disease ,Cross-Sectional Studies ,ComputingMethodologies_PATTERNRECOGNITION ,over-treatment ,business - Abstract
WOS: 000384041400052, PubMed ID: 27583892, This study aimed to investigate the potential misuse of novel oral anticoagulants (NOACs) and the physicians' adherence to current European guideline recommendations in real-world using a large dataset from Real-life Multicenter Survey Evaluating Stroke Prevention Strategies in Turkey (RAMSES Study).RAMSES study is a prospective, multicenter, nationwide registry (ClinicalTrials.gov identifier NCT02344901). In this subgroup analysis of RAMSES study, patients who were on NOACs were classified as appropriately treated (AT), undertreated (UT), and overtreated (OT) according to the European Society of Cardiology (ESC) guidelines. The independent predictors of UT and OT were determined by multivariate logistic regression.Of the 2086 eligible patients, 1247 (59.8%) received adequate treatment. However, off-label use was detected in 839 (40.2%) patients; 634 (30.4%) patients received UT and 205 (9.8%) received OT. Independent predictors of UT included >65 years of age, creatinine clearance 50mL/min, urban living, existing dabigatran treatment, and HAS-BLED score of
- Published
- 2016
35. Executive dysfunction accompanying essential tremor.
- Author
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Dogan H, Bilen S, and Ergin Beton O
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Young Adult, Case-Control Studies, Tremor, Cognition Disorders psychology, Cognitive Dysfunction etiology, Cognitive Dysfunction complications, Essential Tremor complications, Essential Tremor diagnosis, Essential Tremor pathology
- Abstract
Essential tremor (ET) is one of the most common neurological diseases. New evidence suggest that ET is associated with cognitive disorders other than motor symptoms. We aimed to investigate executive dysfunctions, which are comorbid cognitive deficiencies that may accompany ET. The study was conducted as an observational, case-control study in the Neurology Department of Ankara City Hospital in a 3-month period. The "Fahn-Tolosa-Marin Tremor Evaluation Scale" was used to rate tremor severity. Both patients and control group were subjected to the Mini Mental Test, followed by the Stroop TBAG test (TBAG is composed of the first letters of "TUBİTAK Temel Bilimler Araştırma Grubu," which means Scientific and Technological Research Council of Turkey Basic Sciences Research Group), word fluency (category fluency), phonemic fluency (K), and abstract thinking (binary similarities, proverb interpretation) tests. Both the patient and the control group consisted of 20 women and 20 men, with age, gender, and educational background compatible. Mean age of the patient group was 34.80 ± 13.23 years, while it was 34.95 ± 10.21 years in control group. In the ET group, statistically significant impairment was detected in the Stroop Test section 5 duration and error + correction number, category fluency, binary similarity, and phonemic fluency tests compared to the control group. There was a correlation between the severity of tremor and especially Stroop, category fluency, and binary similarity tests such that, as the severity of tremor increased, these test scores deteriorated. In ET patients, an impairment, accompanying tremor, may be present in executive functions that are a part of frontal lobe functions even in younger patients. This finding may suggest that impairment in the cerebellum-thalamus-frontal lobe connection may play a role in ET pathology.
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- 2024
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36. The potential association between COVID-19 disease and Guillain-Barré syndrome.
- Author
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Ergin Beton O, Ozturk Tan O, and Bilen S
- Subjects
- Humans, Lymphocytes, Pandemics, Retrospective Studies, COVID-19 complications, Guillain-Barre Syndrome epidemiology
- Abstract
The aim is to investigate the rate of GBS in the pre- and postpandemic period and potential differences in probable COVID-19-associated Guillain-Barré syndrome (GBS) cases and nonassociated cases. The medical records of individuals older than 18 years who were hospitalized with acute and rapidly developing progressive extremity weakness between March 2019 and March 2021 were analyzed retrospectively, and the rate of GBS 1 year before the first reported COVID-19 case (March 2020) in Turkey and 1 year later was compared. Neurological symptoms, medical histories, and GBS disability scores, as well as the findings of electrophysiological, blood, and cerebrospinal fluid (CSF) investigations at the time of presentation, were reviewed. The GBS cases were divided into those with confirmed COVID-19 within 6 weeks before the clinical presentation of GBS and those without COVID-19. The rate of COVID-19 was significantly higher in the patients with GBS as an etiological factor. When the probable COVID-19-associated GBS cases and nonassociated cases were compared, there was a significant between-group difference with respect to sedimentation, C-reactive protein, D-dimer, ferritin, albumin, lymphocyte number, mean platelet volume, neutrophil-lymphocyte ratio, fibrinogen, and lactate dehydrogenase values. In addition, there was a significant between-group difference in admission and discharge disability scores. The GBS rate did not increase after the COVID-19 pandemic, but probable COVID-19-associated GBS significantly affected inflammatory markers and admission-discharge GBS disability scores.
- Published
- 2022
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37. Procedural Characteristics, Safety, and Follow-up of Modified Right-Sided Approach for Cardioneuroablation.
- Author
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Candemir B, Baskovski E, Beton O, Shanableh N, Akbulut İM, Kozluca V, Esenboğa K, Tan TS, Altın T, and Tutar E
- Subjects
- Electrocardiography, Ambulatory methods, Follow-Up Studies, Humans, Catheter Ablation methods, Syncope, Vasovagal diagnosis, Syncope, Vasovagal surgery
- Abstract
Background: Cardioneuroablation is one of the emerging therapies in vasovagal syncope. In this study, we present a simple method of cardioneuroablation performed via a rightsided approach, targeting anterior-right and right-inferior ganglionated plexi, along with procedural and follow-up data., Methods: Patients who had underwent cardioneuroablation between March 2018 and September 2019 with vasovagal syncope in 2 clinics were enrolled in the study. All patients underwent radio-anatomically guided radiofrequency ablation targeting anterior-right ganglionated plexi and right-inferior ganglionated plexi. Syncope and symptom burden, 24-hour ambulatory electrocardiogram data at presentation, and at follow-up were assessed along with procedural data., Results: A total of 23 patients underwent modified right-sided cardioneuroablation. Mean basal cycle length decreased significantly from 862.3 ± 174.5 ms at the beginning of the procedure 695.8 ± 152.1 ms following the final radiofrequency ablation (P < .001). Mean 24-hour ambulatory heart rate increased significantly from 66.4 ± 10.7 bpm at baseline to 80 ± 7.6 bpm at follow-up (P < .001). Only 1 patient had 1 episode of syncope following the procedure at the mean follow-up period of 10 ± 2.9 months. The same patient had recurrent presyncope., Conclusion: The right-sided cardioneuroablation approach was found to be an effective treatment for vasovagal syncope and may be regarded as a default initial cardioneuroablation technique.
- Published
- 2022
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38. Long-Term Results of Pulmonary Vein Isolation Plus Modified Posterior Wall Debulking Utilizing High-Power Short-Duration Strategy: An All-Comers Study in Real World.
- Author
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Candemir B, Baskovski E, Beton O, Kozluca V, Tan TS, Altın T, and Tutar E
- Subjects
- Cytoreduction Surgical Procedures, Humans, Recurrence, Retrospective Studies, Treatment Outcome, Atrial Fibrillation, Catheter Ablation methods, Pulmonary Veins surgery
- Abstract
Background: High-power short-duration radiofrequency ablation has improved lesion durability in pulmonary vein isolation. In this study, we investigate long-term clinical out-comes of high-power short-duration pulmonary vein isolation and posterior wall debulk- ing as an initial treatment modality in all corner atrial fibrillation patients., Methods: This is a single-center, retrospective, observational study including all patients who have undergone high-power short-duration pulmonary vein and posterior wall deb-ulking, regardless of atrial fibrillation type and/or duration. High-power short-duration power delivery protocol was defined as 45 W at all ablation sites. Clinical and electrocar-diographic follow-up were performed in all patients., Results: One hundred forty-two patients were enrolled in this study. Paroxysmal atrial fibrillation was present in 88 (62%) of patients. The mean follow-up of this study was 36.9 months ± 12.2 months. During the follow-up period, 10 patients (11.4%) with a diag- nosis of paroxysmal atrial fibrillation had recurrence, while recurrence in patients with persistent and long-standing persistent atrial fibrillation was slightly higher (15 patients (28.1%) and 5 patients (50%), respectively). No major life-threatening complicationsoccurred., Conclusion: This study has demonstrated excellent arrhythmia-free outcomes in unselected, real world atrial fibrillation patients undergoing high-power short-duration pulmonary vein and debulking posterior wall isolations, however larger randomized trials are warranted.
- Published
- 2022
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39. Which is the best for the warfarin monitoring: Following up by fixed or variable physician?
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Asarcikli LD, Kafes H, Sen T, Ipek EG, Beton O, Temizhan A, and Yilmaz MB
- Abstract
Objective: Warfarin therapy has some difficulties in terms of close monitoring and dosage. This study aims to evaluate the effect of same-fixed versus different-variable physician-based monitoring of warfarin therapy on treatment quality and clinical end-points., Methods: A total of 625 consecutive patients requiring warfarin treatment were enrolled at seven centers. INR values of the patients measured at each visit and registered to hospital database were recorded. Time in therapeutic range (TTR) was calculated using linear interpolation method (Rosendaal's method). A TTR value of ≥65% was considered as effective warfarin treatment. If a patient was evaluated by the same-fixed physician at each INR visit, was categorized into the same-physician (SP) group. In contrast, if a patient was evaluated by different-variable physicians at each INR visit, was categorized into variable physician (VP) group. Enrolled patients were followed up for bleeding and embolic events., Results: One hundred and fifty-six patients (24.9%) were followed by SP group, 469 (75.1%) patients were followed by VP group. Median TTR value of the VP group was lower than that of SP group (56.2% vs. 65.1%, respectively, p=0.009). During median 25.5 months (9-36) of follow-up, minor bleeding, major bleeding and cerebral embolic event rates were higher in VP group compared to SP group (p<0.001, p=0.023, p<0.001, respectively). In multivariate analysis, INR monitoring by VP group was found to be an independent predictor of increased risk of bleeding events (OR 2.55, 95% CI 1.64-3.96, p<0.001) and embolism (OR 3.42, 95% CI 1.66-7.04, p=0.001)., Conclusion: INR monitoring by same physician was associated with better TTR and lower rates of adverse events during follow-up. Hence, it is worth encouraging an SP-based outpatient follow-up system at least for where warfarin therapy is the only choice., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors., (Copyright © 2022 by Istanbul Provincial Directorate of Health - Available online at www.northclinist.com.)
- Published
- 2022
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40. Is the Prevalence of Coronary Artery Anomalies Different in Countries with Small Populations? - A Retrospective Study in Northern Cyprus.
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Muhtaroglu M, Lafci Fahrioglu S, Beton O, and İlgi S
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Coronary Angiography, Coronary Vessel Anomalies classification, Coronary Vessel Anomalies diagnostic imaging, Cyprus epidemiology, Female, Humans, Incidence, Male, Middle Aged, Prevalence, Retrospective Studies, Young Adult, Coronary Vessel Anomalies epidemiology, Population Density
- Abstract
Background: Although the prevalence of coronary artery anomalies (CAA) is due to accidental and rare discoveries, it varies between different countries or geographies. CAA are rare congenital disorders having various clinical definitions. Its prevalence varies in angiographic and autopsy series in adult populations and is approximately 1% in average. While the incidence ranges from 0.2% to 5.64% in coronary angiographic (CAG) studies, it is around 0.3% in autopsy series. We aimed to estimate the frequency of CAA in our patient population., Methods: The coronary angiographic data of 4099 consecutive adult patients, who underwent CAG between January 2019 and December 2020, were analyzed and retrospectively studied., Results: The mean age of the total patients who underwent CAG was 61.59 ± 13.67 years (range, 18-98 years). CAA were found in 76 patients (1.85% incidence), origin and course anomaly in 62 patients (81.6%), and coronary artery termination anomaly in 14 patients (18.4%). Separate exits of the left anterior descending (LAD) and left circumflex (LCX) coronary artery from the left sinus of Valsalva (LSV) were the most common anomalies (36.84%). Coronary artery fistulas were seen in 14 (18.42%) patients. Abnormal origin of left circumflex artery (LCX) from the right coronary artery (RCA) or right sinus valsalva (RSV) was seen in 13 (17.11%) patients. Outflow anomalies from the contralateral coronary sinus were detected in 10 (13.16%) patients., Conclusion: The incidence and pattern of CAA in our patient population showed similarity with previous studies. Physicians should be aware of CAA that may be associated with potentially serious cardiac incidents, because recognition of these CAA is important for the decision of treatment procedures.
- Published
- 2021
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41. The Anatomical History of a Single Coronary Artery Anomaly: A Case Report.
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Muhtaroglu M, Fahrioglu SL, Beton O, and İlgi S
- Subjects
- Coronary Vessel Anomalies surgery, Humans, Male, Middle Aged, Percutaneous Coronary Intervention methods, Computed Tomography Angiography methods, Coronary Angiography methods, Coronary Vessel Anomalies diagnosis, Coronary Vessels anatomy & histology
- Abstract
Single coronary artery(SCA) anomaly is a rare anomaly where the right and left coronary arteries arise from a single ostium in the sinus valsalva and feed the whole heart. Although asymptomatic in most cases, it can cause angina, syncope, myocardial infarction and sudden cardiac death. It is essential to diagnose it especially in terms of the risk of encountering clinical pictures such as sudden death at a young age and its association with other congenital anomalies. In this report, we present a patient with a SCA anomaly. During an emergency conventional angiography, a right coronary artery(RCA) arising from the left main coronary artery(LMCA) originating from a single ostium was detected in the aorta.
- Published
- 2021
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42. MicroRNA-221/222 expression in atherosclerotic coronary artery plaque versus internal mammarian artery and in peripheral blood samples.
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Bildirici AE, Arslan S, Özbilüm Şahin N, Berkan Ö, Beton O, and Yilmaz MB
- Subjects
- Aged, Biomarkers blood, Case-Control Studies, Coronary Artery Disease blood, Female, Gene Expression, Humans, Hypercholesterolemia blood, Hypertension blood, Male, Medical History Taking, MicroRNAs blood, Middle Aged, Plaque, Atherosclerotic genetics, Mammary Arteries metabolism, MicroRNAs metabolism, Plaque, Atherosclerotic metabolism
- Abstract
Background: Atherosclerosis is a disease of the arterial wall with predilection to some sites on others. MicroRNAs (miRNAs) are a class of the non-coding RNAs regulating the target gene expression at post-transcriptional level. Different miRNAs were found at distinct stages of plaque development and expression of miRNAs' might play an important role in the local behaviour of atherosclerotic plaques., Objective: We aimed to investigate and compare mirR-221/222 expression levels in tissues and in circulation in patients with and without overt atherosclerosis., Methods: RNA was isolated from 40 tissues as 20 tissue samples from coronary artery atherosclerotic plaques (CAAP) and internal mammary arteries (IMA), obtained from same individual) and 80 blood (44 patients with atherosclerosis and 36 healthy subjects) samples. MiR-221/222 expression levels were measured using real time PCR., Results: Expression levels of miR-221 was significantly increased in CAAP compared with completely atherosclerosis-free IMA tissues with a 8.94 times fold-change (p = 0.015). The miR-221 expression in tissue samples was significantly different in patients with hypercholesterolemia (p = 0.010), hypertension (p = 0.018) and family history of CAD (p = 0.033) versus not. Expression of miR-222 was not statistically significant between the two tissue samples overall., Conclusions: MiR-221 may be a potential biomarker for local atherosclerotic behavior.
- Published
- 2018
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43. Drug Adherence in Patients With Nonvalvular Atrial Fibrillation Taking Non-Vitamin K Antagonist Oral Anticoagulants in Turkey: NOAC-TR.
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Emren SV, Şenöz O, Bilgin M, Beton O, Aslan A, Taşkin U, Açiksari G, Asarcikli LD, Çakir H, Bekar L, Bolat İ, Yayla Ç, Çelebi B, Dalgiç O, Çelik O, Şafak Ö, Akyel S, Güngör H, Düzel B, and Zoghi M
- Subjects
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Hemorrhage, Humans, Male, Middle Aged, Self Report, Stroke, Turkey, Anticoagulants therapeutic use, Atrial Fibrillation drug therapy, Medication Adherence
- Abstract
Adherence to non-vitamin K antagonist oral anticoagulants (NOACs) is an important factor for ensuring efficacy and safety in nonvalvular atrial fibrillation (NVAF). There are controversial results regarding NOAC adherence in real-world data and there are no data about NOAC adherence in Turkish population. This study investigated the NOAC adherence based on self-report, factors affecting nonadherence, and the relation of the adherence level with efficacy and safety outcomes. This multicenter cross-sectional study included 2738 patients (59% female) using NOAC (dabigatran, apixaban, and rivaroxaban) due to NVAF for more than 3 months with >30 days of supply between September 1, 2015, and February 28, 2016. To measure the adherence level, an 8-item Morisky Medication Adherence Scale was used. The mean age of the patients was 70 ± 10 years. Of the 2738 patients, 44% were receiving dabigatran, 38% rivaroxaban, and 18% apixaban. A total of 630 (23%) patients had high medication adherence, 712 (26%) moderate adherence, and 1396 (51%) low adherence. Nonadherence had related to stroke (5.6% vs 2.5%, P < .001) and minor (21.2% vs 11.1%, P < .001) and major (6.1% vs 3.7%, P = .004) bleeding rates. The adherence to NOAC was found to be quite low in Turkey. Nonadherence is associated with bleeding and thromboembolic cardiovascular events. Age, taking NOAC twice a day, and the additional noncardiac diseases, depression, and dementia were the independent factors affecting poor medication adherence.
- Published
- 2018
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44. Effects of MPO-463G/A and - 129G/A polymorphisms on coronary artery disease risk and patient survival in a Turkish population.
- Author
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Arslan S, Berkan Ö, Bayyurt B, Beton O, Şahin NLÖL, and Aydemir EI
- Abstract
Myeloperoxidase (MPO) is an oxidative hemoprotein compound expressed in polymorphonuclear leukocytes that contributes to inflammatory responses. Coronary artery disease (CAD), as the most prevalent form of heart disease, is considered to originate from an interaction between genetic and environmental factors. In the present study, the potential associations between MPO-463G/A and - 129G/A polymorphisms with CAD were investigated in a Turkish population using a polymerase chain reaction-based restriction fragment length polymorphism (RFLP) assay technique. To the best of our knowledge, the study was the first to examine the association of MPO-463G/A and - 129G/A with patient survival rate in a Turkish population. The study population consisted of 201 patients with CAD and 201 healthy controls. The results indicated that there was a significant association of the GA genotype of MPO-463G/A with the case population (P=0.048). Meanwhile, in the patients with CAD, the frequency distributions of the MPO-129A allele (P=0.006) and GA genotype (P=0.001) were significantly increased compared with the G allele and GG genotype, respectively, in CAD patients. Additionally, compared with the GG genotype, the frequency distribution of MPO-129A was significantly increased in the patient group regarding smoking status (P=0.001) and the presence of hypercholesterolemia (P=0.028). However, survival analysis did not detect an effect of either polymorphism on the survival rate of the CAD patients (P>0.05). Therefore, the MPO-129GA genotype may be a significant risk factor for the development of CAD.
- Published
- 2017
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45. Demonstration of Ischemia in Myocardial Perfusion Scintigraphy before Coronary Revascularization Decreases Acute Coronary Syndrome-related Hospitalizations.
- Author
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Kaya H, Kandemir O, Beton O, Kivrak T, Kurt R, and Yilmaz MB
- Abstract
In this study, we compared the patients who underwent coronary angiography (CAG), followed by revascularization by coronary artery stent implantation according to the CAG results without any evidence of ischemia with myocardial perfusion scintigraphy (MPS), and the patients who underwent revascularization by coronary artery stent implantation following the detection of ischemia in MPS before CAG in terms of the mortality and hospitalization due to acute coronary syndrome (ACS). Between January 2009 and January 2016, a total of 407 patients (52% males, 48% females; mean age: 66 ± 9 years; range: 40-85 years) who underwent CAG following diagnosis of stable angina and underwent coronary artery stenting were retrospectively analyzed. The patients were divided into two groups: Group 1 ( n = 200) included those who had MPS before CAG and in whom ischemia was detected and stent was implanted, and Group 2 ( n = 207) included those who had stent implantation according to the CAG results without prior MPS. The mean follow-up was 40 ± 18 months. Although there was no significant difference in the mortality rates between the groups, the rate of hospitalization due to ACS was significantly lower in Group 1 ( P = 0.112 vs. P = 0.022, respectively). According to the multivariate Cox-regression analysis, demonstration of ischemia in MPS before revascularization, statin use, clopidogrel use, and higher high-density lipoprotein cholesterol levels were found to be associated with a reduced risk of ACS-related hospitalization, whereas the presence of diabetes mellitus and smoking was found to be associated with an increased risk of ACS-related hospitalization., Competing Interests: There are no conflicts of interest.
- Published
- 2017
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46. Real-world stroke prevention strategies in nonvalvular atrial fibrillation in patients with renal impairment.
- Author
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Mert KU, Mert GÖ, Başaran Ö, Beton O, Dogan V, Tekinalp M, Aykan AÇ, Kalaycıoğlu E, Bolat I, Taşar O, Şafak Ö, Kalçık M, Yaman M, Kırma C, and Biteker M
- Subjects
- Administration, Oral, Aged, Anticoagulants therapeutic use, Female, Fibrinolytic Agents therapeutic use, Glomerular Filtration Rate physiology, Humans, Male, Platelet Aggregation Inhibitors therapeutic use, Prospective Studies, Pulmonary Disease, Chronic Obstructive complications, Registries, Renal Insufficiency, Chronic physiopathology, Stroke complications, Atrial Fibrillation complications, Renal Insufficiency, Chronic complications, Stroke prevention & control
- Abstract
Background: The data regarding stroke prevention strategies in nonvalvular atrial fibrillation (NVAF) are limited especially in patients with renal impairment (RI). We sought to evaluate management dilemmas in patients with concurrent NVAF and RI in RAMSES (ReAl-life Multicenter Survey Evaluating Stroke Prevention Strategies inTurkey) study., Methods: We conducted a prospective, multicenter, nation-wide registry in NVAF patients in outpatient cardiology clinics. All consecutive patients with NVAF were enrolled in RAMSES study (ClinicalTrials.gov identifier NCT02344901). The baseline data were collected. Glomerular filtration rate (GFR) was estimated by Cockcroft-Gault equation., Results: A total number of 6273 patients from 29 provinces of Turkey with the contribution of 83 investigators were enrolled to the study. Of the study population, 1964(33%) patients had RI which was defined as GFR < 60 mL/min. Patients with RI had significantly higher CHA
2 DS2 VASc and HAS-BLED scores compared to those without RI (3·9 ± 1·5 vs. 2·9 ± 1·5, and 2·0 ± 1 vs. 1·4 ± 1; P < 0·001). Prior history of major bleeding (6·9% vs. 4·1%, P < 0·001) and stroke (16·2% vs. 11·8%, P < 0·001) was significantly higher among individuals with concomitant RI and NVAF. Although RI patients had a higher risk for thromboembolism, number of the patients who did not receive any anticoagulant therapy was higher in patients with RI than without RI (30·1 vs. 26·4%, P = 0·003)., Conclusion: RAMSES study showed that one-third of the patients with NVAF had RI in the real-world setting. Although it is mandatory in most of the patients with concomitant NVAF and RI, nearly one-third of these patients did not receive any anticoagulant therapy., (© 2017 Stichting European Society for Clinical Investigation Journal Foundation.)- Published
- 2017
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47. Flow and Diameter Changes of Forearm Arteries During Temporary Unilateral Reciprocal Occlusion: A Prospective Observational Study.
- Author
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Kaplanoglu H and Beton O
- Subjects
- Blood Flow Velocity, Constriction, Female, Forearm diagnostic imaging, Humans, Male, Middle Aged, Prospective Studies, Regional Blood Flow, Forearm blood supply, Radial Artery diagnostic imaging, Radial Artery physiopathology, Ulnar Artery diagnostic imaging, Ulnar Artery physiopathology, Ultrasonography, Doppler methods
- Abstract
Purpose: Transradial and transulnar artery approaches are commonly used for percutaneous interventions, with considerably low risk of developing hand ischemia, for reasons that have not been fully understood. The aim of this study was to evaluate the changes in the diameter, peak systolic flow velocity (PSV), and volume flow (VF) of the radial (RA) and ulnar artery (UA) during unilateral reciprocal temporary occlusion., Methods: A total of 204 extremity arteries of 102 consecutive patients were evaluated using Doppler ultrasonography. At the level of the wrist, RA and UA were consecutively compressed for 60 seconds. The diameter, PSV, and VF parameters of both arteries were evaluated during unilateral reciprocal compression., Results: Compared with the baseline values, the median (interquartile range) increases in diameter, PSV, and VF were 0.2 (0.1-0.3) mm, 6.8 (1.7-17.5) cm/s, and 1.9 (0.8-10) ml/min, respectively, for RA, and 0.1 (0.1-0.3) mm, 9.4 (2.6-18.0) cm/s, and 10.0 (0.0-20.0) ml/min, respectively, for UA during reciprocal compression (p < 0.001 for all)., Conclusions: Reciprocal compression significantly increased the diameter, PSV, and VF of both arteries during reciprocal compression. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:197-203, 2017., (© 2017 Wiley Periodicals, Inc.)
- Published
- 2017
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48. Mean Platelet Volume as a Predictor of Heart Failure-Related Hospitalizations in Stable Heart Failure Outpatients with Sinus Rhythm.
- Author
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Kaya H, Kutay Yıldırımlı M, Kurt R, Beton O, and Birhan Yilmaz M
- Abstract
Background: In this study, we investigated the relationship between the mean platelet volume (MPV) with mortality and heart failure (HF)-related hospitalization in stable chronic HF outpatients with reduced ejection fraction (HFrEF) and with sinus rhythm (SR)., Methods: This retrospective cohort study included 197 consecutive stable chronic HFrEF outpatients with SR, who were admitted to our cardiology outpatient clinics for examination between January 2014 and January 2015. According to the receiver-operating characteristic curve analysis, the optimal cut-off value of MPV to predict HF-related hospitalization was > 9.1 fL. Patients were classified into two categories according to threshold MPV levels, as group I with MPV ≤ 9.1 fL and group II with MPV > 9.1 fL., Results: The mean age of patients was 65 ± 13 years. The mean follow-up duration was 10 ± 3 months, and 44 patients (22%) succumbed to cardiovascular (CV) death. The rate of CV mortality was similar between the two groups (21% vs. 24%, p = 0.649). However, the rate of patients who experienced HF-related hospitalization was lower in group I compared with group II (41% vs. 87%, p < 0.001, respectively). Univariate analysis demonstrated associations of many clinical factors in addition to increased MPV > 9.1 fL with HF-related hospitalization; however, In the multivariate Cox proportional-hazards model, only increased MPV > 9.1 fL (HR: 2.895, 95% CI: 1.774-4.724, p < 0.001), systolic pulmonary artery pressure level (HR: 1.018, 95% CI: 1.001-1.036, p = 0.048) and pre-admission beta blocker use (HR: 0.517, 95% CI: 0.305-0.877, p = 0.014) remained associated with a risk of HF-related hospitalization., Conclusions: The mean platelet volume might be a useful parameter for risk stratification with regard to HF-related hospitalization in HFrEF outpatients with SR.
- Published
- 2017
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49. Prediction of fractional flow reserve with angiographic DILEMMA score.
- Author
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Beton O, Kaya H, Turgut OO, and Yılmaz MB
- Subjects
- Coronary Angiography, Coronary Stenosis physiopathology, Female, Humans, Male, Middle Aged, Predictive Value of Tests, ROC Curve, Retrospective Studies, Coronary Stenosis diagnostic imaging, Fractional Flow Reserve, Myocardial, Severity of Illness Index
- Abstract
Objective: Angiographic assessment of stenosis has limited predictive value for functionally significant lesions compared with fractional flow reserve (FFR). The recently developed angiographic DILEMMA score, which consists of minimal lumen diameter (MLD), lesion length (LL) and Bypass Angioplasty Revascularization Investigation (BARI) Myocardial Jeopardy Index (MJI) was found to have diagnostic value in predicting FFR ≤0.80. The present study was an investigation of prediction of FFR ≤0.80 using DILEMMA score and its relationship to resting distal coronary artery pressure/aortic pressure (Pd/Pa)., Methods: Records of consecutive patients who underwent coronary angiography and FFR were retrospectively analyzed. Assessment of MLD and LL was performed using quantitative coronary angiography. BARI MJI was calculated using angiographic calculation index., Results: A total of 185 pressure wire analysis data sets from 150 patients were analyzed retrospectively. There were 82 lesions in FFR >0.80 group and 103 lesions in FFR ≤0.80 group. Negative correlation was found between FFR and DILEMMA score (r=-0.494; p<0.001), FFR and BARI-MJI (r=-0.378; p<0.001), and between FFR and LL (r=-0.314; p<0.001). Positive correlation was found between FFR and baseline Pd/Pa (r=0.713; p<0.001), and between FFR and MLD (r=0.415; p<0.001). DILEMMA score had negative correlation with resting Pd/Pa (r=-0.389; p<0.001). In receiver operating characteristic analysis for diagnosing FFR≤0.80, area under curve values of resting Pd/Pa, DILEMMA score, MLD, BARI-MJI, and LL were 0.862, 0.793, 0.780, 0.728, and 0.686, respectively., Conclusion: DILEMMA score had moderately strong correlation with FFR and good accuracy in diagnosing significant FFR, but it had weak correlation with resting Pd/Pa.
- Published
- 2017
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50. Evaluation of anatomy and variations of superficial palmar arch and upper extremity arteries with CT angiography.
- Author
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Kaplanoglu H and Beton O
- Subjects
- Aged, Brachial Artery diagnostic imaging, Computed Tomography Angiography, Female, Humans, Male, Middle Aged, Radial Artery diagnostic imaging, Retrospective Studies, Ulnar Artery diagnostic imaging, Upper Extremity diagnostic imaging, Anatomic Variation, Brachial Artery anatomy & histology, Radial Artery anatomy & histology, Ulnar Artery anatomy & histology, Upper Extremity blood supply
- Abstract
Aim: To evaluate the abnormalities and variations of the arterial system of upper extremities and superficial palmar arch with computed tomography angiography and to guide the clinician during this procedure., Methods: A total of 156 upper extremities of 78 cases were retrospectively analyzed using computed tomography angiography. The study was approved by the local ethics committee of the hospital. From the analysis of the computed tomography angiography images, the following information was recorded; the diameters and abnormalities of radial, ulnar and brachial arteries in both upper extremities, the presence of atherosclerotic changes or stenosis in these arteries, whether the superficial palmar arch was complete or incomplete, and arterial dominance. Also, the computed tomography angiography classification of superficial palmar arch distribution and anatomic configuration was performed., Results: The mean baseline diameters of the radial, ulnar and brachial arteries of the cases were; 2.8 ± 0.6, 2.5 ± 0.7, and 4.7 ± 0.6 mm, respectively. A complete superficial palmar arch was observed in 69.2 % of the right hands and 70.5 % of the left hands. For the superficial palmar arches on the right side, the radial artery was dominant in two and the ulnar artery was dominant in 47 with the remaining showing codominance. On the left side, the radial artery was dominant in one hand, with the ulnar artery being dominant in 49 cases, and in 28 cases, there was codominance. In the superficial palmar arch classification, four of the arches (A-D) were defined as complete and the remaining three (E-G) as incomplete., Conclusion: The current study clarified different variations in palmar circulation and forearm arteries to aid the surgeon during trans-radial or trans-ulnar catheterization, hemodialysis, or coronary artery bypass grafting.
- Published
- 2017
- Full Text
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