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246 results on '"Bettini, Simona"'

12. Chiral Recognition by Supramolecular Porphyrin–Hemicucurbit[8]uril-Functionalized Gravimetric Sensors

Author

Magna, Gabriele, primary, Šakarašvili, Marko, additional, Stefanelli, Manuela, additional, Giancane, Gabriele, additional, Bettini, Simona, additional, Valli, Ludovico, additional, Ustrnul, Lukas, additional, Borovkov, Victor, additional, Aav, Riina, additional, Monti, Donato, additional, Di Natale, Corrado, additional, and Paolesse, Roberto, additional

Published
2023
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31. An insight on type I collagen from horse tendon for the manufacture of implantable devices

Author

Salvatore, Luca, primary, Gallo, Nunzia, additional, Aiello, Donatella, additional, Lunetti, Paola, additional, Barca, Amilcare, additional, Blasi, Laura, additional, Madaghiele, Marta, additional, Bettini, Simona, additional, Giancane, Gabriele, additional, Hasan, Mohammed, additional, Borovkov, Victor, additional, Natali, Maria L., additional, Campa, Lorena, additional, Valli, Ludovico, additional, Capobianco, Loredana, additional, Napoli, Anna, additional, and Sannino, Alessandro, additional

Published
2020
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34. Sub‐ and Supramolecular X‐Ray Characterization of Engineered Tissues from Equine Tendon, Bovine Dermis, and Fish Skin Type‐I Collagen

Author

Terzi, Alberta, primary, Gallo, Nunzia, additional, Bettini, Simona, additional, Sibillano, Teresa, additional, Altamura, Davide, additional, Madaghiele, Marta, additional, De Caro, Liberato, additional, Valli, Ludovico, additional, Salvatore, Luca, additional, Sannino, Alessandro, additional, and Giannini, Cinzia, additional

Published
2020
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39. Investigations of Processing–Induced Structural Changes in Horse Type-I Collagen at Sub and Supramolecular Levels

Author

Terzi, Alberta, primary, Gallo, Nunzia, additional, Bettini, Simona, additional, Sibillano, Teresa, additional, Altamura, Davide, additional, Campa, Lorena, additional, Natali, Maria Lucia, additional, Salvatore, Luca, additional, Madaghiele, Marta, additional, De Caro, Liberato, additional, Valli, Ludovico, additional, Sannino, Alessandro, additional, and Giannini, Cinzia, additional

Published
2019
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41. Assessment of physico-chemical and biological properties of sericin-collagen substrates for PNS regeneration.

Author

Gallo, Nunzia, Lunetti, Paola, Bettini, Simona, Barca, Amilcare, Madaghiele, Marta, Valli, Ludovico, Capobianco, Loredana, Sannino, Alessandro, and Salvatore, Luca

Subjects
NERVOUS system regeneration, PERIPHERAL nervous system, COLLAGEN, FOURIER transform infrared spectroscopy, SCHWANN cells, QUALITY of life
Abstract

Peripheral nerve injuries may lead to a significant function loss, which deeply affect patient's quality of life. In this context, tissue engineered collagen-based nerve guides are a promising alternative to autografts. To enhance the regeneration of the injured nerve tract, several bioactive molecules can be adopted as further components of the collagen-based conduits. Herein, sericin (Ser), a waste product of textile industry, was combined with type I collagen (Col), for the development of a bioactive substrate potentially able to support and enhance the regeneration of the peripheral nervous system. In particular, in order to identify an optimal substrate composition in terms of physicochemical and biological properties, thin Ser-Col films with different Ser:Col ratios were produced by air-drying and subsequently crosslinked through two different crosslinking methods. Then, Ser:Col films were characterized from a physicochemical point of view by examining secondary protein structure modifications via FTIR spectroscopy, swelling ratios, degradation rates and Ser release kinetics. Moreover, Ser:Col films ability to promote adhesion and proliferation of Schwann cells was evaluated in vitro. The results obtained in this study, although preliminary, suggest that Ser:Col blends could represent a promising strategy to enhance the repair of damaged peripheral nerves, by providing a sustained release of Ser from collagen-based nerve substrates. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Synthesis of an Innovative Paramagnetic Porous Collagen-Based Scaffold

Author

BONFRATE, VALENTINA, BETTINI, SIMONA, SALVATORE, LUCA, MADAGHIELE, Marta, VALLI, Ludovico, GIANCANE, Gabriele, SANNINO, Alessandro, Bonfrate, Valentina, Bettini, Simona, Salvatore, Luca, Madaghiele, Marta, Valli, Ludovico, Giancane, Gabriele, and Sannino, Alessandro

Subjects
technology, industry, and agriculture
Abstract

INTRODUCTION Magnetic responsive materials are the topic of intense research due to their potential breakthrough applications in the biomedical, coatings, microfluidics and microelectronics fields. By merging magnetic and polymer materials one can obtain composites with exceptional magnetic responsive features. Magnetic actuation provides unique capabilities as it can be spatially and temporally controlled, and can additionally be operated externally to the system, providing a non-invasive approach to remote control.[1] Porous biomaterials fabricated from natural and synthetic polymers have been intensively studied and widely used as drug delivery vehicles and scaffolds for tissue regeneration. Collagen is a natural polymer with an excellent biocompatibility and low antigenicity but with a rapid degradation and poor mechanical properties. These drawbacks limit its use in biomedical applications. In this context, a hybrid system, formed by a porous collagen scaffold and magnetite nanoparticles with a TiO2 shell (NPs@TiO2), was prepared in order to merge the potentiality of the paramagnetic material and the biocompatibility of the protein scaffold. The core/shell nanoparticles were also used as a novel crosslinker agent, as TiO2 guaranteed the binding to carboxylic groups[2] of collagen. In this way, scaffold mechanical properties and stability were also improved by the embedded nanoparticles. EXPERIMENTAL METHODS Synthesis of Porous Collagen Scaffold. An aqueous suspension of 1% w/v Type I collagen from bovine dermis was prepared by stirring for 5-6 hours at 10°C. A porous collagen scaffold was then obtained by casting, freeze-drying and dehydrothermal crosslinking (DHT). Synthesis of Porous Paramagnetic Collagen Scaffold. An aqueous solution of NPs@TiO2 was added to the collagen slurry while stirring. The suspension was then treated as reported above for the porous collagen scaffold. Characterization experiments. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetrical analysis (TGA) and swelling studies were carried out. The release of NPs@TiO2 from the collagen scaffold was studied by means of inductively coupled plasma mass spectroscopy analysis (ICP-MS). RESULTS AND DISCUSSION Paramagnetic iron oxide nanoparticles with a shell of TiO2 were incorporated within a collagen scaffold to obtain a hybrid porous material. This collagen-based matrix was highly sensitive to an external magnetic field. The optimal NPs@TiO2 concentration was determined by incorporating different amounts of nanoparticles into the collagen matrix, as quantified by means of TGA. The interaction among nanoparticles and the collagen fibers was studied by FTIR spectroscopy. As widely reported in the literature[2], TiO2 is able to bind carboxyl groups. In addition, we activated collagen carboxyl groups using N-hydroxysuccinimide (NHS) and 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide (EDC), to prompt the connection of these groups to the TiO2 coating. In order to evaluate the effect of NPs@TiO2 on the morphology of the collagen scaffold, scanning electron microscopy (SEM) was carried out. In the presence of NPs@TiO2, the average pore size of the collagen matrices was significantly reduced. This finding seemed to suggest that paramagnetic NPs worked as crosslinkers among the collagen fibers, inducing a rearrangement of the whole matrix. Swelling studies confirmed the fact that the NPs@TiO2, interacting with the collagen polymer matrix, played the role of crosslinkers [3]. The release of NPs@TiO2 from the matrix was monitored by incubating the samples in a phosphate buffered saline solution (pH 7.4) for 4 weeks at 37 °C. At each time point, iron release from the samples was determined using ICP-MS. The bond between NPs@TiO2 and collagen was thus found to be highly stable. CONCLUSION The results obtained in this study suggest the possibility to use a collagen matrices crosslinked with TiO2 coated paramagnetic iron oxide nanoparticles as potential biocompatible actuators that can be driven by external magnetic fields. Such characteristics make these innovative materials very appealing for different applications, such as drug delivery and tissue engineering.

Published
2015

49. Biocompatible Collagen Paramagnetic Scaffold for Controlled Drug Release

Author

BONFRATE, VALENTINA, BETTINI, SIMONA, SALVATORE, LUCA, MADAGHIELE, Marta, VALLI, Ludovico, GIANCANE, Gabriele, SANNINO, Alessandro, Bonfrate, Valentina, Bettini, Simona, Salvatore, Luca, Madaghiele, Marta, Valli, Ludovico, Giancane, Gabriele, and Sannino, Alessandro

Published
2015

50. SiO2‐Coated ZnO Nanoflakes Decorated with Ag Nanoparticles for Photocatalytic Water Oxidation.

Author

Bettini, Simona, Pagano, Rosanna, Semeraro, Paola, Ottolini, Michela, Salvatore, Luca, Marzo, Fabio, Lovergine, Nicola, Giancane, Gabriele, and Valli, Ludovico

Subjects
*PHOTOCATALYTIC oxidation, *OXIDATION of water, *SURFACE plasmon resonance, *METAL nanoparticles, *SILVER nanoparticles, *NANOPARTICLES, *ZINC oxide
Abstract

Many strategies have been adopted to improve the photoinduced features of zinc oxide nanostructures for different application fields. In this work, zinc oxide has been synthesised and decorated by plasmonic metal nanoparticles to enhance its photocatalytic activity in the visible range. Furthermore, an insulating layer of SiO2 has been grown between the surface of zinc oxide nanoflakes and silver nanoparticles. A synthetic procedure that allows the accurate modulation of the insulating layer thickness in the range 5–40 nm has been developed. Evidences highlight the crucial role of the SiO2 layer in dramatically increasing photocatalytic water oxidation promoted by the nanostructure under both UV and visible illumination. An ideal thickness value of about 10 nm has been demonstrated to guarantee the plasmon‐induced resonance energy‐transfer process and to quench the Förster resonance energy‐transfer mechanism; thus, optimising the local surface plasmon resonance effect and water oxidation properties. [ABSTRACT FROM AUTHOR]

Published
2019
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