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154 results on '"Betts, Courtney B."'

1. Entinostat in combination with nivolumab in metastatic pancreatic ductal adenocarcinoma: a phase 2 clinical trial

Author

Baretti, Marina, Danilova, Ludmila, Durham, Jennifer N., Betts, Courtney B., Cope, Leslie, Sidiropoulos, Dimitrios N., Tandurella, Joseph A., Charmsaz, Soren, Gross, Nicole, Hernandez, Alexei, Ho, Won Jin, Thoburn, Chris, Walker, Rosalind, Leatherman, James, Mitchell, Sarah, Christmas, Brian, Saeed, Ali, Gaykalova, Daria A., Yegnasubramanian, Srinivasan, Fertig, Elana J., Coussens, Lisa M., Yarchoan, Mark, Jaffee, Elizabeth, and Azad, Nilofer S.

Published
2024
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2. A cancer cell-intrinsic GOT2-PPARd axis suppresses antitumor immunity

Author

Abrego, Jaime, Sanford-Crane, Hannah, Oon, Chet, Xiao, Xu, Betts, Courtney B, Sun, Duanchen, Nagarajan, Shanthi, Diaz, Luis, Sandborg, Holly, Bhattacharyya, Sohinee, Xia, Zheng, Coussens, Lisa M, Tontonoz, Peter, and Sherman, Mara H

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Immunology, Oncology and Carcinogenesis, Genetics, Pancreatic Cancer, Digestive Diseases, Rare Diseases, Immunotherapy, Cancer, 2.1 Biological and endogenous factors, Inflammatory and immune system, Aspartate Aminotransferases, Aspartic Acid, Carcinoma, Pancreatic Ductal, Fatty Acids, Humans, Ligands, Malates, PPAR delta, Pancreatic Neoplasms, Tumor Microenvironment, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Despite significant recent advances in precision medicine, pancreatic ductal adenocarcinoma (PDAC) remains near uniformly lethal. Although immune-modulatory therapies hold promise to meaningfully improve outcomes for patients with PDAC, the development of such therapies requires an improved understanding of the immune evasion mechanisms that characterize the PDAC microenvironment. Here, we show that cancer cell-intrinsic glutamic-oxaloacetic transaminase 2 (GOT2) shapes the immune microenvironment to suppress antitumor immunity. Mechanistically, we find that GOT2 functions beyond its established role in the malate-aspartate shuttle and promotes the transcriptional activity of nuclear receptor peroxisome proliferator-activated receptor delta (PPARδ), facilitated by direct fatty acid binding. Although GOT2 is dispensable for cancer cell proliferation in vivo, the GOT2-PPARδ axis promotes spatial restriction of both CD4+ and CD8+ T cells from the tumor microenvironment. Our results demonstrate a noncanonical function for an established mitochondrial enzyme in transcriptional regulation of immune evasion, which may be exploitable to promote a productive antitumor immune response.SignificancePrior studies demonstrate the important moonlighting functions of metabolic enzymes in cancer. We find that the mitochondrial transaminase GOT2 binds directly to fatty acid ligands that regulate the nuclear receptor PPARδ, and this functional interaction critically regulates the immune microenvironment of pancreatic cancer to promote tumor progression. See related commentary by Nwosu and di Magliano, p. 2237.. This article is highlighted in the In This Issue feature, p. 2221.

Published
2022

3. Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study

Author

Taylor, Matthew H, Betts, Courtney B, Maloney, Lauren, Nadler, Eric, Algazi, Alain, Guarino, Michael J, Nemunaitis, John, Jimeno, Antonio, Patel, Priti, Munugalavadla, Veerendra, Tao, Lin, Adkins, Douglas, Goldschmidt, Jerome H, Cohen, Ezra EW, and Coussens, Lisa M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Rare Diseases, Cancer, Orphan Drug, Clinical Trials and Supportive Activities, Clinical Research, Dental/Oral and Craniofacial Disease, Minority Health, Health Disparities, 6.1 Pharmaceuticals, 5.1 Pharmaceuticals, 6.2 Cellular and gene therapies, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols, Benzamides, Head and Neck Neoplasms, Humans, Programmed Cell Death 1 Receptor, Proteomics, Pyrazines, Squamous Cell Carcinoma of Head and Neck, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposeProgrammed cell death-1 (PD-1) receptor inhibitors have shown efficacy in head and neck squamous cell carcinoma (HNSCC), but treatment failure or secondary resistance occurs in most patients. In preclinical murine carcinoma models, inhibition of Bruton's tyrosine kinase (BTK) induces myeloid cell reprogramming that subsequently bolsters CD8+ T cell responses, resulting in enhanced antitumor activity. This phase 2, multicenter, open-label, randomized study evaluated pembrolizumab (anti-PD-1 monoclonal antibody) plus acalabrutinib (BTK inhibitor) in recurrent or metastatic HNSCC.Patients and methodsPatients received pembrolizumab 200 mg intravenously every 3 weeks, alone or in combination with acalabrutinib 100 mg orally twice daily. Safety and overall response rate (ORR) were co-primary objectives. The secondary objectives were progression-free survival (PFS) and overall survival.ResultsSeventy-six patients were evaluated (pembrolizumab, n = 39; pembrolizumab + acalabrutinib, n = 37). Higher frequencies of grade 3-4 treatment-emergent adverse events (AE; 65% vs. 39%) and serious AEs (68% vs. 31%) were observed with combination therapy versus monotherapy. ORR was 18% with monotherapy versus 14% with combination therapy. Median PFS was 2.7 [95% confidence interval (CI), 1.4-6.8] months in the combination arm and 1.7 (95% CI, 1.4-4.0) months in the monotherapy arm. The study was terminated due to lack of clinical benefit with combination treatment. To assess how tumor immune contexture was affected by therapy in patients with pre- and post-treatment biopsies, spatial proteomic analyses were conducted that revealed a trend toward increased CD45+ leukocyte infiltration of tumors from baseline at day 43 with pembrolizumab (monotherapy, n = 5; combination, n = 2), which appeared to be higher in combination-treated patients; however, definitive conclusions could not be drawn due to limited sample size.ConclusionsDespite lack of clinical efficacy, immune subset analyses suggest that there are additive effects of this combination; however, the associated toxicity limits the feasibility of combination treatment with pembrolizumab and acalabrutinib in patients with recurrent or metastatic HNSCC.

Published
2022

5. Natural killer cells occupy unique spatial neighborhoods in HER2- and HER2+ human breast cancers.

Author

Ehlers, Femke A. I., Blise, Katie E., Betts, Courtney B., Sivagnanam, Shamilene, Kooreman, Loes F. S., Hwang, E. Shelley, Bos, Gerard M. J., Wieten, Lotte, and Coussens, Lisa M.

Subjects
KILLER cells, CELL analysis, TUMOR-infiltrating immune cells, MEDICAL sciences, BREAST cancer
Abstract

Tumor-infiltrating lymphocytes are considered clinically beneficial in breast cancer, but the significance of natural killer (NK) cells is less well characterized. As increasing evidence has demonstrated that the spatial organization of immune cells in tumor microenvironments is a significant parameter for impacting disease progression as well as therapeutic responses, an improved understanding of tumor-infiltrating NK cells and their location within tumor contextures is needed to improve the design of effective NK cell-based therapies. In this study, we developed a multiplex immunohistochemistry (mIHC) antibody panel designed to quantitatively interrogate leukocyte lineages, focusing on NK cells and their phenotypes, in two independent breast cancer patient cohorts (n = 26 and n = 30). Owing to the clinical evidence supporting a significant role for NK cells in HER2+ breast cancer in mediating responses to Trastuzumab, we further evaluated HER2- and HER2+ specimens separately. Consistent with literature, we found that CD3+ T cells were the dominant leukocyte subset across breast cancer specimens. In comparison, NK cells, identified by CD56 or NKp46 expression, were scarce in all specimens with low granzyme B expression indicating reduced cytotoxic functionality. Whereas NK cell density and phenotype did not appear to be influenced by HER2 status, spatial analysis revealed distinct NK cells phenotypes regarding their proximity to neoplastic tumor cells that associated with HER2 status. Spatial cellular neighborhood analysis revealed multiple unique neighborhood compositions surrounding NK cells, where NK cells from HER2- tumors were more frequently found proximal to neoplastic tumor cells, whereas NK cells from HER2+ tumors were instead more frequently found proximal to CD3+ T cells. This study establishes the utility of quantitative mIHC to evaluate NK cells at the single-cell spatial proteomics level and illustrates how spatial characteristics of NK cell neighborhoods vary within the context of HER2- and HER2+ breast cancers. [ABSTRACT FROM AUTHOR]

Published
2025
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7. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Author

Aberle, Denise, Achilefu, Samuel I., Ademuyiwa, Foluso O., Adey, Andrew C., Aft, Rebecca L., Agarwal, Rachana, Aguilar, Ruben A., Alikarami, Fatemeh, Allaj, Viola, Amos, Christopher, Anders, Robert A., Angelo, Michael R., Anton, Kristen, Ashenberg, Orr, Aster, Jon C., Babur, Ozgun, Bahmani, Amir, Balsubramani, Akshay, Barrett, David, Beane, Jennifer, Bender, Diane E., Bernt, Kathrin, Berry, Lynne, Betts, Courtney B., Bletz, Julie, Blise, Katie, Boire, Adrienne, Boland, Genevieve, Borowsky, Alexander, Bosse, Kristopher, Bott, Matthew, Boyden, Ed, Brooks, James, Bueno, Raphael, Burlingame, Erik A., Cai, Qiuyin, Campbell, Joshua, Caravan, Wagma, Cerami, Ethan, Chaib, Hassan, Chan, Joseph M., Chang, Young Hwan, Chatterjee, Deyali, Chaudhary, Ojasvi, Chen, Alyce A., Chen, Bob, Chen, Changya, Chen, Chia-hui, Chen, Feng, Chen, Yu-An, Chheda, Milan G., Chin, Koei, Chiu, Roxanne, Chu, Shih-Kai, Chuaqui, Rodrigo, Chun, Jaeyoung, Cisneros, Luis, Coffey, Robert J., Colditz, Graham A., Cole, Kristina, Collins, Natalie, Contrepois, Kevin, Coussens, Lisa M., Creason, Allison L., Crichton, Daniel, Curtis, Christina, Davidsen, Tanja, Davies, Sherri R., de Bruijn, Ino, Dellostritto, Laura, De Marzo, Angelo, Demir, Emek, DeNardo, David G., Diep, Dinh, Ding, Li, Diskin, Sharon, Doan, Xengie, Drewes, Julia, Dubinett, Stephen, Dyer, Michael, Egger, Jacklynn, Eng, Jennifer, Engelhardt, Barbara, Erwin, Graham, Esplin, Edward D., Esserman, Laura, Felmeister, Alex, Feiler, Heidi S., Fields, Ryan C., Fisher, Stephen, Flaherty, Keith, Flournoy, Jennifer, Ford, James M., Fortunato, Angelo, Frangieh, Allison, Frye, Jennifer L., Fulton, Robert S., Galipeau, Danielle, Gan, Siting, Gao, Jianjiong, Gao, Long, Gao, Peng, Gao, Vianne R., Geiger, Tim, George, Ajit, Getz, Gad, Ghosh, Sharmistha, Giannakis, Marios, Gibbs, David L., Gillanders, William E., Goecks, Jeremy, Goedegebuure, Simon P., Gould, Alanna, Gowers, Kate, Gray, Joe W., Greenleaf, William, Gresham, Jeremy, Guerriero, Jennifer L., Guha, Tuhin K., Guimaraes, Alexander R., Guinney, Justin, Gutman, David, Hacohen, Nir, Hanlon, Sean, Hansen, Casey R., Harismendy, Olivier, Harris, Kathleen A., Hata, Aaron, Hayashi, Akimasa, Heiser, Cody, Helvie, Karla, Herndon, John M., Hirst, Gilliam, Hodi, Frank, Hollmann, Travis, Horning, Aaron, Hsieh, James J., Hughes, Shannon, Huh, Won Jae, Hunger, Stephen, Hwang, Shelley E., Iacobuzio-Donahue, Christine A., Ijaz, Heba, Izar, Benjamin, Jacobson, Connor A., Janes, Samuel, Jané-Valbuena, Judit, Jayasinghe, Reyka G., Jiang, Lihua, Johnson, Brett E., Johnson, Bruce, Ju, Tao, Kadara, Humam, Kaestner, Klaus, Kagan, Jacob, Kalinke, Lukas, Keith, Robert, Khan, Aziz, Kibbe, Warren, Kim, Albert H., Kim, Erika, Kim, Junhyong, Kolodzie, Annette, Kopytra, Mateusz, Kotler, Eran, Krueger, Robert, Krysan, Kostyantyn, Kundaje, Anshul, Ladabaum, Uri, Lake, Blue B., Lam, Huy, Laquindanum, Rozelle, Lau, Ken S., Laughney, Ashley M., Lee, Hayan, Lenburg, Marc, Leonard, Carina, Leshchiner, Ignaty, Levy, Rochelle, Li, Jerry, Lian, Christine G., Lim, Kian-Huat, Lin, Jia-Ren, Lin, Yiyun, Liu, Qi, Liu, Ruiyang, Lively, Tracy, Longabaugh, William J.R., Longacre, Teri, Ma, Cynthia X., Macedonia, Mary Catherine, Madison, Tyler, Maher, Christopher A., Maitra, Anirban, Makinen, Netta, Makowski, Danika, Maley, Carlo, Maliga, Zoltan, Mallo, Diego, Maris, John, Markham, Nick, Marks, Jeffrey, Martinez, Daniel, Mashl, Robert J., Masilionais, Ignas, Mason, Jennifer, Massagué, Joan, Massion, Pierre, Mattar, Marissa, Mazurchuk, Richard, Mazutis, Linas, Mazzilli, Sarah A., McKinley, Eliot T., McMichael, Joshua F., Merrick, Daniel, Meyerson, Matthew, Miessner, Julia R., Mills, Gordon B., Mills, Meredith, Mondal, Suman B., Mori, Motomi, Mori, Yuriko, Moses, Elizabeth, Mosse, Yael, Muhlich, Jeremy L., Murphy, George F., Navin, Nicholas E., Nawy, Tal, Nederlof, Michel, Ness, Reid, Nevins, Stephanie, Nikolov, Milen, Nirmal, Ajit Johnson, Nolan, Garry, Novikov, Edward, Oberdoerffer, Philipp, O’Connell, Brendan, Offin, Michael, Oh, Stephen T., Olson, Anastasiya, Ooms, Alex, Ossandon, Miguel, Owzar, Kouros, Parmar, Swapnil, Patel, Tasleema, Patti, Gary J., Pe’er, Dana, Pe'er, Itsik, Peng, Tao, Persson, Daniel, Petty, Marvin, Pfister, Hanspeter, Polyak, Kornelia, Pourfarhangi, Kamyar, Puram, Sidharth V., Qiu, Qi, Quintanal-Villalonga, Álvaro, Raj, Arjun, Ramirez-Solano, Marisol, Rashid, Rumana, Reeb, Ashley N., Regev, Aviv, Reid, Mary, Resnick, Adam, Reynolds, Sheila M., Riesterer, Jessica L., Rodig, Scott, Roland, Joseph T., Rosenfield, Sonia, Rotem, Asaf, Roy, Sudipta, Rozenblatt-Rosen, Orit, Rudin, Charles M., Ryser, Marc D., Santagata, Sandro, Santi-Vicini, Maria, Sato, Kazuhito, Schapiro, Denis, Schrag, Deborah, Schultz, Nikolaus, Sears, Cynthia L., Sears, Rosalie C., Sen, Subrata, Sen, Triparna, Shalek, Alex, Sheng, Jeff, Sheng, Quanhu, Shoghi, Kooresh I., Shrubsole, Martha J., Shyr, Yu, Sibley, Alexander B., Siex, Kiara, Simmons, Alan J., Singer, Dinah S., Sivagnanam, Shamilene, Slyper, Michal, Snyder, Michael P., Sokolov, Artem, Song, Sheng-Kwei, Sorger, Peter K., Southard-Smith, Austin, Spira, Avrum, Srivastava, Sudhir, Stein, Janet, Storm, Phillip, Stover, Elizabeth, Strand, Siri H., Su, Timothy, Sudar, Damir, Sullivan, Ryan, Surrey, Lea, Suvà, Mario, Tan, Kai, Terekhanova, Nadezhda V., Ternes, Luke, Thammavong, Lisa, Thibault, Guillaume, Thomas, George V., Thorsson, Vésteinn, Todres, Ellen, Tran, Linh, Tyler, Madison, Uzun, Yasin, Vachani, Anil, Van Allen, Eliezer, Vandekar, Simon, Veis, Deborah J., Vigneau, Sébastien, Vossough, Arastoo, Waanders, Angela, Wagle, Nikhil, Wang, Liang-Bo, Wendl, Michael C., West, Robert, Williams, Elizabeth H., Wu, Chi-yun, Wu, Hao, Wu, Hung-Yi, Wyczalkowski, Matthew A., Xie, Yubin, Yang, Xiaolu, Yapp, Clarence, Yu, Wenbao, Yuan, Yinyin, Zhang, Dadong, Zhang, Kun, Zhang, Mianlei, Zhang, Nancy, Zhang, Yantian, Zhao, Yanyan, Zhou, Daniel Cui, Zhou, Zilu, Zhu, Houxiang, Zhu, Qin, Zhu, Xiangzhu, Zhu, Yuankun, Zhuang, Xiaowei, Hupalowska, Anna, Rood, Jennifer E., Hanlon, Sean E., Hughes, Shannon K., Hwang, E. Shelley, Johnson, Bruce E., Shalek, Alex K., Spira, Avrum E., and West, Robert B.

Published
2020
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9. Machine learning links T-cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer

Author

Blise, Katie E., primary, Sivagnanam, Shamilene, additional, Betts, Courtney B., additional, Betre, Konjit, additional, Kirchberger, Nell, additional, Tate, Benjamin J., additional, Furth, Emma E., additional, Dias Costa, Andressa, additional, Nowak, Jonathan A., additional, Wolpin, Brian M., additional, Vonderheide, Robert H., additional, Goecks, Jeremy, additional, Coussens, Lisa M., additional, and Byrne, Katelyn T., additional

Published
2024
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10. Data from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., primary, Mick, Rosemarie, primary, Sivagnanam, Shamilene, primary, Bajor, David L., primary, Laheru, Daniel A., primary, Chiorean, E. Gabriela, primary, O'Hara, Mark H., primary, Liudahl, Shannon M., primary, Newcomb, Craig, primary, Alanio, Cécile, primary, Ferreira, Ana P., primary, Park, Byung S., primary, Ohtani, Takuya, primary, Huffman, Austin P., primary, Väyrynen, Sara A., primary, Dias Costa, Andressa, primary, Kaiser, Judith C., primary, Lacroix, Andreanne M., primary, Redlinger, Colleen, primary, Stern, Martin, primary, Nowak, Jonathan A., primary, Wherry, E. John, primary, Cheever, Martin A., primary, Wolpin, Brian M., primary, Furth, Emma E., primary, Jaffee, Elizabeth M., primary, Coussens, Lisa M., primary, and Vonderheide, Robert H., primary

Published
2024
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11. Supplementary Table 2 from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., primary, Mick, Rosemarie, primary, Sivagnanam, Shamilene, primary, Bajor, David L., primary, Laheru, Daniel A., primary, Chiorean, E. Gabriela, primary, O'Hara, Mark H., primary, Liudahl, Shannon M., primary, Newcomb, Craig, primary, Alanio, Cécile, primary, Ferreira, Ana P., primary, Park, Byung S., primary, Ohtani, Takuya, primary, Huffman, Austin P., primary, Väyrynen, Sara A., primary, Dias Costa, Andressa, primary, Kaiser, Judith C., primary, Lacroix, Andreanne M., primary, Redlinger, Colleen, primary, Stern, Martin, primary, Nowak, Jonathan A., primary, Wherry, E. John, primary, Cheever, Martin A., primary, Wolpin, Brian M., primary, Furth, Emma E., primary, Jaffee, Elizabeth M., primary, Coussens, Lisa M., primary, and Vonderheide, Robert H., primary

Published
2024
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12. Supplementary Figure 1 from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., primary, Mick, Rosemarie, primary, Sivagnanam, Shamilene, primary, Bajor, David L., primary, Laheru, Daniel A., primary, Chiorean, E. Gabriela, primary, O'Hara, Mark H., primary, Liudahl, Shannon M., primary, Newcomb, Craig, primary, Alanio, Cécile, primary, Ferreira, Ana P., primary, Park, Byung S., primary, Ohtani, Takuya, primary, Huffman, Austin P., primary, Väyrynen, Sara A., primary, Dias Costa, Andressa, primary, Kaiser, Judith C., primary, Lacroix, Andreanne M., primary, Redlinger, Colleen, primary, Stern, Martin, primary, Nowak, Jonathan A., primary, Wherry, E. John, primary, Cheever, Martin A., primary, Wolpin, Brian M., primary, Furth, Emma E., primary, Jaffee, Elizabeth M., primary, Coussens, Lisa M., primary, and Vonderheide, Robert H., primary

Published
2024
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13. Supplementary Figure 2 from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., primary, Mick, Rosemarie, primary, Sivagnanam, Shamilene, primary, Bajor, David L., primary, Laheru, Daniel A., primary, Chiorean, E. Gabriela, primary, O'Hara, Mark H., primary, Liudahl, Shannon M., primary, Newcomb, Craig, primary, Alanio, Cécile, primary, Ferreira, Ana P., primary, Park, Byung S., primary, Ohtani, Takuya, primary, Huffman, Austin P., primary, Väyrynen, Sara A., primary, Dias Costa, Andressa, primary, Kaiser, Judith C., primary, Lacroix, Andreanne M., primary, Redlinger, Colleen, primary, Stern, Martin, primary, Nowak, Jonathan A., primary, Wherry, E. John, primary, Cheever, Martin A., primary, Wolpin, Brian M., primary, Furth, Emma E., primary, Jaffee, Elizabeth M., primary, Coussens, Lisa M., primary, and Vonderheide, Robert H., primary

Published
2024
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14. Supplementary Table 3 from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., primary, Mick, Rosemarie, primary, Sivagnanam, Shamilene, primary, Bajor, David L., primary, Laheru, Daniel A., primary, Chiorean, E. Gabriela, primary, O'Hara, Mark H., primary, Liudahl, Shannon M., primary, Newcomb, Craig, primary, Alanio, Cécile, primary, Ferreira, Ana P., primary, Park, Byung S., primary, Ohtani, Takuya, primary, Huffman, Austin P., primary, Väyrynen, Sara A., primary, Dias Costa, Andressa, primary, Kaiser, Judith C., primary, Lacroix, Andreanne M., primary, Redlinger, Colleen, primary, Stern, Martin, primary, Nowak, Jonathan A., primary, Wherry, E. John, primary, Cheever, Martin A., primary, Wolpin, Brian M., primary, Furth, Emma E., primary, Jaffee, Elizabeth M., primary, Coussens, Lisa M., primary, and Vonderheide, Robert H., primary

Published
2024
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15. Supplementary Figure 3 from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., primary, Mick, Rosemarie, primary, Sivagnanam, Shamilene, primary, Bajor, David L., primary, Laheru, Daniel A., primary, Chiorean, E. Gabriela, primary, O'Hara, Mark H., primary, Liudahl, Shannon M., primary, Newcomb, Craig, primary, Alanio, Cécile, primary, Ferreira, Ana P., primary, Park, Byung S., primary, Ohtani, Takuya, primary, Huffman, Austin P., primary, Väyrynen, Sara A., primary, Dias Costa, Andressa, primary, Kaiser, Judith C., primary, Lacroix, Andreanne M., primary, Redlinger, Colleen, primary, Stern, Martin, primary, Nowak, Jonathan A., primary, Wherry, E. John, primary, Cheever, Martin A., primary, Wolpin, Brian M., primary, Furth, Emma E., primary, Jaffee, Elizabeth M., primary, Coussens, Lisa M., primary, and Vonderheide, Robert H., primary

Published
2024
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16. Supplementary Table 4 from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., primary, Mick, Rosemarie, primary, Sivagnanam, Shamilene, primary, Bajor, David L., primary, Laheru, Daniel A., primary, Chiorean, E. Gabriela, primary, O'Hara, Mark H., primary, Liudahl, Shannon M., primary, Newcomb, Craig, primary, Alanio, Cécile, primary, Ferreira, Ana P., primary, Park, Byung S., primary, Ohtani, Takuya, primary, Huffman, Austin P., primary, Väyrynen, Sara A., primary, Dias Costa, Andressa, primary, Kaiser, Judith C., primary, Lacroix, Andreanne M., primary, Redlinger, Colleen, primary, Stern, Martin, primary, Nowak, Jonathan A., primary, Wherry, E. John, primary, Cheever, Martin A., primary, Wolpin, Brian M., primary, Furth, Emma E., primary, Jaffee, Elizabeth M., primary, Coussens, Lisa M., primary, and Vonderheide, Robert H., primary

Published
2024
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17. Supplementary Table 1 from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., primary, Mick, Rosemarie, primary, Sivagnanam, Shamilene, primary, Bajor, David L., primary, Laheru, Daniel A., primary, Chiorean, E. Gabriela, primary, O'Hara, Mark H., primary, Liudahl, Shannon M., primary, Newcomb, Craig, primary, Alanio, Cécile, primary, Ferreira, Ana P., primary, Park, Byung S., primary, Ohtani, Takuya, primary, Huffman, Austin P., primary, Väyrynen, Sara A., primary, Dias Costa, Andressa, primary, Kaiser, Judith C., primary, Lacroix, Andreanne M., primary, Redlinger, Colleen, primary, Stern, Martin, primary, Nowak, Jonathan A., primary, Wherry, E. John, primary, Cheever, Martin A., primary, Wolpin, Brian M., primary, Furth, Emma E., primary, Jaffee, Elizabeth M., primary, Coussens, Lisa M., primary, and Vonderheide, Robert H., primary

Published
2024
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18. Supplementary Figure 4 from Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., primary, Mick, Rosemarie, primary, Sivagnanam, Shamilene, primary, Bajor, David L., primary, Laheru, Daniel A., primary, Chiorean, E. Gabriela, primary, O'Hara, Mark H., primary, Liudahl, Shannon M., primary, Newcomb, Craig, primary, Alanio, Cécile, primary, Ferreira, Ana P., primary, Park, Byung S., primary, Ohtani, Takuya, primary, Huffman, Austin P., primary, Väyrynen, Sara A., primary, Dias Costa, Andressa, primary, Kaiser, Judith C., primary, Lacroix, Andreanne M., primary, Redlinger, Colleen, primary, Stern, Martin, primary, Nowak, Jonathan A., primary, Wherry, E. John, primary, Cheever, Martin A., primary, Wolpin, Brian M., primary, Furth, Emma E., primary, Jaffee, Elizabeth M., primary, Coussens, Lisa M., primary, and Vonderheide, Robert H., primary

Published
2024
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19. Machine learning links T cell function and spatial localization to neoadjuvant immunotherapy and clinical outcome in pancreatic cancer

Author

Blise, Katie E., primary, Sivagnanam, Shamilene, additional, Betts, Courtney B., additional, Betre, Konjit, additional, Kirchberger, Nell, additional, Tate, Benjamin, additional, Furth, Emma E., additional, Dias Costa, Andressa, additional, Nowak, Jonathan A., additional, Wolpin, Brian M., additional, Vonderheide, Robert H., additional, Goecks, Jeremy, additional, Coussens, Lisa M., additional, and Byrne, Katelyn T., additional

Published
2023
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20. High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers

Author

Banik, Grace, primary, Betts, Courtney B., additional, Liudahl, Shannon M., additional, Sivagnanam, Shamilene, additional, Kawashima, Rie, additional, Cotechini, Tiziana, additional, Larson, William, additional, Goecks, Jeremy, additional, Pai, Sara I., additional, Clayburgh, Daniel R., additional, Tsujikawa, Takahiro, additional, and Coussens, Lisa M., additional

Published
2020
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22. Data from A Cancer Cell–Intrinsic GOT2–PPARδ Axis Suppresses Antitumor Immunity

Author

Abrego, Jaime, primary, Sanford-Crane, Hannah, primary, Oon, Chet, primary, Xiao, Xu, primary, Betts, Courtney B., primary, Sun, Duanchen, primary, Nagarajan, Shanthi, primary, Diaz, Luis, primary, Sandborg, Holly, primary, Bhattacharyya, Sohinee, primary, Xia, Zheng, primary, Coussens, Lisa M., primary, Tontonoz, Peter, primary, and Sherman, Mara H., primary

Published
2023
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23. Supplementary Figure from A Cancer Cell–Intrinsic GOT2–PPARδ Axis Suppresses Antitumor Immunity

Author

Abrego, Jaime, primary, Sanford-Crane, Hannah, primary, Oon, Chet, primary, Xiao, Xu, primary, Betts, Courtney B., primary, Sun, Duanchen, primary, Nagarajan, Shanthi, primary, Diaz, Luis, primary, Sandborg, Holly, primary, Bhattacharyya, Sohinee, primary, Xia, Zheng, primary, Coussens, Lisa M., primary, Tontonoz, Peter, primary, and Sherman, Mara H., primary

Published
2023
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24. Supplementary Data from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome

Author

Liudahl, Shannon M., primary, Betts, Courtney B., primary, Sivagnanam, Shamilene, primary, Morales-Oyarvide, Vicente, primary, da Silva, Annacarolina, primary, Yuan, Chen, primary, Hwang, Samuel, primary, Grossblatt-Wait, Alison, primary, Leis, Kenna R., primary, Larson, William, primary, Lavoie, Meghan B., primary, Robinson, Padraic, primary, Dias Costa, Andressa, primary, Väyrynen, Sara A., primary, Clancy, Thomas E., primary, Rubinson, Douglas A., primary, Link, Jason, primary, Keith, Dove, primary, Horton, Wesley, primary, Tempero, Margaret A., primary, Vonderheide, Robert H., primary, Jaffee, Elizabeth M., primary, Sheppard, Brett, primary, Goecks, Jeremy, primary, Sears, Rosalie C., primary, Park, Byung S., primary, Mori, Motomi, primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, and Coussens, Lisa M., primary

Published
2023
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25. Figure S2 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome

Author

Liudahl, Shannon M., primary, Betts, Courtney B., primary, Sivagnanam, Shamilene, primary, Morales-Oyarvide, Vicente, primary, da Silva, Annacarolina, primary, Yuan, Chen, primary, Hwang, Samuel, primary, Grossblatt-Wait, Alison, primary, Leis, Kenna R., primary, Larson, William, primary, Lavoie, Meghan B., primary, Robinson, Padraic, primary, Dias Costa, Andressa, primary, Väyrynen, Sara A., primary, Clancy, Thomas E., primary, Rubinson, Douglas A., primary, Link, Jason, primary, Keith, Dove, primary, Horton, Wesley, primary, Tempero, Margaret A., primary, Vonderheide, Robert H., primary, Jaffee, Elizabeth M., primary, Sheppard, Brett, primary, Goecks, Jeremy, primary, Sears, Rosalie C., primary, Park, Byung S., primary, Mori, Motomi, primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, and Coussens, Lisa M., primary

Published
2023
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26. Data from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome

Author

Liudahl, Shannon M., primary, Betts, Courtney B., primary, Sivagnanam, Shamilene, primary, Morales-Oyarvide, Vicente, primary, da Silva, Annacarolina, primary, Yuan, Chen, primary, Hwang, Samuel, primary, Grossblatt-Wait, Alison, primary, Leis, Kenna R., primary, Larson, William, primary, Lavoie, Meghan B., primary, Robinson, Padraic, primary, Dias Costa, Andressa, primary, Väyrynen, Sara A., primary, Clancy, Thomas E., primary, Rubinson, Douglas A., primary, Link, Jason, primary, Keith, Dove, primary, Horton, Wesley, primary, Tempero, Margaret A., primary, Vonderheide, Robert H., primary, Jaffee, Elizabeth M., primary, Sheppard, Brett, primary, Goecks, Jeremy, primary, Sears, Rosalie C., primary, Park, Byung S., primary, Mori, Motomi, primary, Nowak, Jonathan A., primary, Wolpin, Brian M., primary, and Coussens, Lisa M., primary

Published
2023
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27. Supplementary Figure from Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study

Author

Taylor, Matthew H., primary, Betts, Courtney B., primary, Maloney, Lauren, primary, Nadler, Eric, primary, Algazi, Alain, primary, Guarino, Michael J., primary, Nemunaitis, John, primary, Jimeno, Antonio, primary, Patel, Priti, primary, Munugalavadla, Veerendra, primary, Tao, Lin, primary, Adkins, Douglas, primary, Goldschmidt, Jerome H., primary, Cohen, Ezra E.W., primary, and Coussens, Lisa M., primary

Published
2023
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28. Supplementary Data from Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study

Author

Taylor, Matthew H., primary, Betts, Courtney B., primary, Maloney, Lauren, primary, Nadler, Eric, primary, Algazi, Alain, primary, Guarino, Michael J., primary, Nemunaitis, John, primary, Jimeno, Antonio, primary, Patel, Priti, primary, Munugalavadla, Veerendra, primary, Tao, Lin, primary, Adkins, Douglas, primary, Goldschmidt, Jerome H., primary, Cohen, Ezra E.W., primary, and Coussens, Lisa M., primary

Published
2023
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33. Axatilimab for Chronic Graft-Versus-Host Disease After Failure of at Least Two Prior Systemic Therapies: Results of a Phase I/II Study

Author

Kitko, Carrie L., primary, Arora, Mukta, additional, DeFilipp, Zachariah, additional, Zaid, Mohammad Abu, additional, Di Stasi, Antonio, additional, Radojcic, Vedran, additional, Betts, Courtney B., additional, Coussens, Lisa M., additional, Meyers, Michael L., additional, Qamoos, Hope, additional, Ordentlich, Peter, additional, Kumar, Vinit, additional, Quaranto, Christine, additional, Schmitt, Aaron, additional, Gu, Yu, additional, Blazar, Bruce R., additional, Wang, Trent P., additional, Salhotra, Amandeep, additional, Pusic, Iskra, additional, Jagasia, Madan, additional, and Lee, Stephanie J., additional

Published
2022
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36. Quantitative Spatial Profiling of Immune Populations Reveals Prognostic Significance in Patients with Pancreatic Ductal Adenocarcinoma

Author

Mi, Haoyang, Sivagnanam, Shamilene, Betts, Courtney B., Liudahl, Shannon M., Coussens, Lisa M., Jaffee, Elizabeth M., and Popel, Aleksander S.

Subjects
Single-cell, endocrine system diseases, Systems Biology, PDAC, Computational pathology, digestive system diseases, TiME
Abstract

Single-cell dataset for the analysis of PDAC TiME

Published
2022
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37. Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer

Author

Lyons, Traci R., Borges, Virginia F., Betts, Courtney B., Guo, Qiuchen, Kapoor, Puja, Martinson, Holly A., Jindal, Sonali, and Schedin, Pepper

Subjects
Drug therapy, Complications and side effects, Patient outcomes, Dosage and administration, Health aspects, COX-2 inhibitors -- Patient outcomes -- Dosage and administration, Pregnancy -- Health aspects, Breast cancer -- Comparative analysis -- Complications and side effects -- Drug therapy, Cancer metastasis -- Drug therapy, Metastasis -- Drug therapy
Abstract

Introduction Postpartum breast involution, which remodels the lactation-competent breast to a nonsecretory state, occurs with weaning or after birth in the absence of lactation. In rodents and women, the process [...], Breast involution following pregnancy has been implicated in the high rates of metastasis observed in postpartum breast cancers; however, it is not clear how this remodeling process promotes metastasis. Here, we demonstrate that human postpartum breast cancers have increased peritumor lymphatic vessel density that correlates with increased frequency of lymph node metastases. Moreover, lymphatic vessel density was increased in normal postpartum breast tissue compared with tissue from nulliparous women. In rodents, mammary lymphangiogenesis was up regulated during weaning-induced mammary gland involution. Furthermore, breast cancer cells exposed to the involuting mammary microenvironment acquired prolymphangiogenic properties that contributed to peritumor lymphatic expansion, tumor size, invasion, and distant metastases. Finally, in rodent models of postpartum breast cancer, cyclooxygenase-2 (COX-2) inhibition during the involution window decreased normal mammary gland lymphangiogenesis, mammary tumor-associated lymphangiogenesis, tumor cell invasion into lymphatics, and metastasis. Our data indicate that physiologic COX-2-dependent lymphangiogenesis occurs in the postpartum mammary gland and suggest that tumors within this mammary microenvironment acquire enhanced prolymphangiogenic activity. Further, our results suggest that the prolymphangiogenic microenvironment of the postpartum mammary gland has potential as a target to inhibit metastasis and suggest that further study of the therapeutic efficacy of COX-2 inhibitors in postpartum breast cancer is warranted.

Published
2014
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39. Axatilimab for Chronic Graft-Versus-Host Disease After Failure of at Least Two Prior Systemic Therapies: Results of a Phase I/II Study.

Author

Kitko, Carrie L., Arora, Mukta, DeFilipp, Zachariah, Zaid, Mohammad Abu, Di Stasi, Antonio, Radojcic, Vedran, Betts, Courtney B., Coussens, Lisa M., Meyers, Michael L., Qamoos, Hope, Ordentlich, Peter, Kumar, Vinit, Quaranto, Christine, Schmitt, Aaron, Gu, Yu, Blazar, Bruce R., Wang, Trent P., Salhotra, Amandeep, Pusic, Iskra, and Jagasia, Madan

Published
2023
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40. An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer

Author

Johnson, Brett E., primary, Creason, Allison L., additional, Stommel, Jayne M., additional, Keck, Jamie M., additional, Parmar, Swapnil, additional, Betts, Courtney B., additional, Blucher, Aurora, additional, Boniface, Christopher, additional, Bucher, Elmar, additional, Burlingame, Erik, additional, Camp, Todd, additional, Chin, Koei, additional, Eng, Jennifer, additional, Estabrook, Joseph, additional, Feiler, Heidi S., additional, Heskett, Michael B., additional, Hu, Zhi, additional, Kolodzie, Annette, additional, Kong, Ben L., additional, Labrie, Marilyne, additional, Lee, Jinho, additional, Leyshock, Patrick, additional, Mitri, Souraya, additional, Patterson, Janice, additional, Riesterer, Jessica L., additional, Sivagnanam, Shamilene, additional, Somers, Julia, additional, Sudar, Damir, additional, Thibault, Guillaume, additional, Weeder, Benjamin R., additional, Zheng, Christina, additional, Nan, Xiaolin, additional, Thompson, Reid F., additional, Heiser, Laura M., additional, Spellman, Paul T., additional, Thomas, George, additional, Demir, Emek, additional, Chang, Young Hwan, additional, Coussens, Lisa M., additional, Guimaraes, Alexander R., additional, Corless, Christopher, additional, Goecks, Jeremy, additional, Bergan, Raymond, additional, Mitri, Zahi, additional, Mills, Gordon B., additional, and Gray, Joe W., additional

Published
2022
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41. Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study

Author

Taylor, Matthew H., primary, Betts, Courtney B., additional, Maloney, Lauren, additional, Nadler, Eric, additional, Algazi, Alain, additional, Guarino, Michael J., additional, Nemunaitis, John, additional, Jimeno, Antonio, additional, Patel, Priti, additional, Munugalavadla, Veerendra, additional, Tao, Lin, additional, Adkins, Douglas, additional, Goldschmidt, Jerome H., additional, Cohen, Ezra E.W., additional, and Coussens, Lisa M., additional

Published
2021
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43. Abstract CT005: T cell inflammation in the tumor microenvironment after agonist CD40 antibody: Clinical and translational results of a neoadjuvant clinical trial

Author

Byrne, Katelyn T., primary, Betts, Courtney B., additional, Mick, Rosemarie, additional, Sivagnanam, Shamilene, additional, Bajor, David L., additional, Laheru, Daniel A., additional, Chiorean, E. Gabriela, additional, O'Hara, Mark H., additional, Liudahl, Shannon M., additional, Newcomb, Craig, additional, Alanio, Cécile, additional, Ferreira, Ana P., additional, Park, Byung S., additional, Ohtani, Takuya, additional, Huffman, Austin P., additional, Väyrynen, Sara A., additional, Costa, Andressa Dias, additional, Kaiser, Judith C., additional, Lacroix, Andreanne M., additional, Redlinger, Colleen, additional, Stern, Martin, additional, Nowak, Jonathan A., additional, Wherry, E. John, additional, Cheever, Martin A., additional, Wolpin, Brian M., additional, Furth, Emma E., additional, Jaffee, Elizabeth M., additional, Coussens, Lisa M., additional, and Vonderheide, Robert H., additional

Published
2021
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44. Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Author

Byrne, Katelyn T., primary, Betts, Courtney B., additional, Mick, Rosemarie, additional, Sivagnanam, Shamilene, additional, Bajor, David L., additional, Laheru, Daniel A., additional, Chiorean, E. Gabriela, additional, O'Hara, Mark H., additional, Liudahl, Shannon M., additional, Newcomb, Craig, additional, Alanio, Cécile, additional, Ferreira, Ana P., additional, Park, Byung S., additional, Ohtani, Takuya, additional, Huffman, Austin P., additional, Väyrynen, Sara A., additional, Dias Costa, Andressa, additional, Kaiser, Judith C., additional, Lacroix, Andreanne M., additional, Redlinger, Colleen, additional, Stern, Martin, additional, Nowak, Jonathan A., additional, Wherry, E. John, additional, Cheever, Martin A., additional, Wolpin, Brian M., additional, Furth, Emma E., additional, Jaffee, Elizabeth M., additional, Coussens, Lisa M., additional, and Vonderheide, Robert H., additional

Published
2021
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46. Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome

Author

Liudahl, Shannon M., primary, Betts, Courtney B., additional, Sivagnanam, Shamilene, additional, Morales-Oyarvide, Vicente, additional, da Silva, Annacarolina, additional, Yuan, Chen, additional, Hwang, Samuel, additional, Grossblatt-Wait, Alison, additional, Leis, Kenna R., additional, Larson, William, additional, Lavoie, Meghan B., additional, Robinson, Padraic, additional, Dias Costa, Andressa, additional, Väyrynen, Sara A., additional, Clancy, Thomas E., additional, Rubinson, Douglas A., additional, Link, Jason, additional, Keith, Dove, additional, Horton, Wesley, additional, Tempero, Margaret A., additional, Vonderheide, Robert H., additional, Jaffee, Elizabeth M., additional, Sheppard, Brett, additional, Goecks, Jeremy, additional, Sears, Rosalie C., additional, Park, Byung S., additional, Mori, Motomi, additional, Nowak, Jonathan A., additional, Wolpin, Brian M., additional, and Coussens, Lisa M., additional

Published
2021
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47. An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

Author

Johnson, Brett E., primary, Creason, Allison L., additional, Stommel, Jayne M., additional, Keck, Jamie M., additional, Parmar, Swapnil, additional, Betts, Courtney B., additional, Blucher, Aurora, additional, Boniface, Christopher, additional, Bucher, Elmar, additional, Burlingame, Erik, additional, Camp, Todd, additional, Chin, Koei, additional, Eng, Jennifer, additional, Estabrook, Joseph, additional, Feiler, Heidi S., additional, Hu, Zhi, additional, Kolodzie, Annette, additional, Kong, Ben L., additional, Labrie, Marilyne, additional, Lee, Jinho, additional, Leyshock, Patrick, additional, Mitri, Souraya, additional, Patterson, Janice, additional, Riesterer, Jessica L., additional, Sivagnanam, Shamilene, additional, Somers, Julia, additional, Sudar, Damir, additional, Thibault, Guillaume, additional, Zheng, Christina, additional, Nan, Xiaolin, additional, Heiser, Laura M., additional, Spellman, Paul T., additional, Thomas, George, additional, Demir, Emek, additional, Chang, Young Hwan, additional, Coussens, Lisa M., additional, Guimaraes, Alexander R., additional, Corless, Christopher, additional, Goecks, Jeremy, additional, Bergan, Raymond, additional, Mitri, Zahi, additional, Mills, Gordon B., additional, and Gray, Joe W., additional

Published
2020
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49. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Author

Rozenblatt-Rosen, Orit, primary, Regev, Aviv, additional, Oberdoerffer, Philipp, additional, Nawy, Tal, additional, Hupalowska, Anna, additional, Rood, Jennifer E., additional, Ashenberg, Orr, additional, Cerami, Ethan, additional, Coffey, Robert J., additional, Demir, Emek, additional, Ding, Li, additional, Esplin, Edward D., additional, Ford, James M., additional, Goecks, Jeremy, additional, Ghosh, Sharmistha, additional, Gray, Joe W., additional, Guinney, Justin, additional, Hanlon, Sean E., additional, Hughes, Shannon K., additional, Hwang, E. Shelley, additional, Iacobuzio-Donahue, Christine A., additional, Jané-Valbuena, Judit, additional, Johnson, Bruce E., additional, Lau, Ken S., additional, Lively, Tracy, additional, Mazzilli, Sarah A., additional, Pe’er, Dana, additional, Santagata, Sandro, additional, Shalek, Alex K., additional, Schapiro, Denis, additional, Snyder, Michael P., additional, Sorger, Peter K., additional, Spira, Avrum E., additional, Srivastava, Sudhir, additional, Tan, Kai, additional, West, Robert B., additional, Williams, Elizabeth H., additional, Aberle, Denise, additional, Achilefu, Samuel I., additional, Ademuyiwa, Foluso O., additional, Adey, Andrew C., additional, Aft, Rebecca L., additional, Agarwal, Rachana, additional, Aguilar, Ruben A., additional, Alikarami, Fatemeh, additional, Allaj, Viola, additional, Amos, Christopher, additional, Anders, Robert A., additional, Angelo, Michael R., additional, Anton, Kristen, additional, Aster, Jon C., additional, Babur, Ozgun, additional, Bahmani, Amir, additional, Balsubramani, Akshay, additional, Barrett, David, additional, Beane, Jennifer, additional, Bender, Diane E., additional, Bernt, Kathrin, additional, Berry, Lynne, additional, Betts, Courtney B., additional, Bletz, Julie, additional, Blise, Katie, additional, Boire, Adrienne, additional, Boland, Genevieve, additional, Borowsky, Alexander, additional, Bosse, Kristopher, additional, Bott, Matthew, additional, Boyden, Ed, additional, Brooks, James, additional, Bueno, Raphael, additional, Burlingame, Erik A., additional, Cai, Qiuyin, additional, Campbell, Joshua, additional, Caravan, Wagma, additional, Chaib, Hassan, additional, Chan, Joseph M., additional, Chang, Young Hwan, additional, Chatterjee, Deyali, additional, Chaudhary, Ojasvi, additional, Chen, Alyce A., additional, Chen, Bob, additional, Chen, Changya, additional, Chen, Chia-hui, additional, Chen, Feng, additional, Chen, Yu-An, additional, Chheda, Milan G., additional, Chin, Koei, additional, Chiu, Roxanne, additional, Chu, Shih-Kai, additional, Chuaqui, Rodrigo, additional, Chun, Jaeyoung, additional, Cisneros, Luis, additional, Colditz, Graham A., additional, Cole, Kristina, additional, Collins, Natalie, additional, Contrepois, Kevin, additional, Coussens, Lisa M., additional, Creason, Allison L., additional, Crichton, Daniel, additional, Curtis, Christina, additional, Davidsen, Tanja, additional, Davies, Sherri R., additional, de Bruijn, Ino, additional, Dellostritto, Laura, additional, De Marzo, Angelo, additional, DeNardo, David G., additional, Diep, Dinh, additional, Diskin, Sharon, additional, Doan, Xengie, additional, Drewes, Julia, additional, Dubinett, Stephen, additional, Dyer, Michael, additional, Egger, Jacklynn, additional, Eng, Jennifer, additional, Engelhardt, Barbara, additional, Erwin, Graham, additional, Esserman, Laura, additional, Felmeister, Alex, additional, Feiler, Heidi S., additional, Fields, Ryan C., additional, Fisher, Stephen, additional, Flaherty, Keith, additional, Flournoy, Jennifer, additional, Fortunato, Angelo, additional, Frangieh, Allison, additional, Frye, Jennifer L., additional, Fulton, Robert S., additional, Galipeau, Danielle, additional, Gan, Siting, additional, Gao, Jianjiong, additional, Gao, Long, additional, Gao, Peng, additional, Gao, Vianne R., additional, Geiger, Tim, additional, George, Ajit, additional, Getz, Gad, additional, Giannakis, Marios, additional, Gibbs, David L., additional, Gillanders, William E., additional, Goedegebuure, Simon P., additional, Gould, Alanna, additional, Gowers, Kate, additional, Greenleaf, William, additional, Gresham, Jeremy, additional, Guerriero, Jennifer L., additional, Guha, Tuhin K., additional, Guimaraes, Alexander R., additional, Gutman, David, additional, Hacohen, Nir, additional, Hanlon, Sean, additional, Hansen, Casey R., additional, Harismendy, Olivier, additional, Harris, Kathleen A., additional, Hata, Aaron, additional, Hayashi, Akimasa, additional, Heiser, Cody, additional, Helvie, Karla, additional, Herndon, John M., additional, Hirst, Gilliam, additional, Hodi, Frank, additional, Hollmann, Travis, additional, Horning, Aaron, additional, Hsieh, James J., additional, Hughes, Shannon, additional, Huh, Won Jae, additional, Hunger, Stephen, additional, Hwang, Shelley E., additional, Ijaz, Heba, additional, Izar, Benjamin, additional, Jacobson, Connor A., additional, Janes, Samuel, additional, Jayasinghe, Reyka G., additional, Jiang, Lihua, additional, Johnson, Brett E., additional, Johnson, Bruce, additional, Ju, Tao, additional, Kadara, Humam, additional, Kaestner, Klaus, additional, Kagan, Jacob, additional, Kalinke, Lukas, additional, Keith, Robert, additional, Khan, Aziz, additional, Kibbe, Warren, additional, Kim, Albert H., additional, Kim, Erika, additional, Kim, Junhyong, additional, Kolodzie, Annette, additional, Kopytra, Mateusz, additional, Kotler, Eran, additional, Krueger, Robert, additional, Krysan, Kostyantyn, additional, Kundaje, Anshul, additional, Ladabaum, Uri, additional, Lake, Blue B., additional, Lam, Huy, additional, Laquindanum, Rozelle, additional, Laughney, Ashley M., additional, Lee, Hayan, additional, Lenburg, Marc, additional, Leonard, Carina, additional, Leshchiner, Ignaty, additional, Levy, Rochelle, additional, Li, Jerry, additional, Lian, Christine G., additional, Lim, Kian-Huat, additional, Lin, Jia-Ren, additional, Lin, Yiyun, additional, Liu, Qi, additional, Liu, Ruiyang, additional, Longabaugh, William J.R., additional, Longacre, Teri, additional, Ma, Cynthia X., additional, Macedonia, Mary Catherine, additional, Madison, Tyler, additional, Maher, Christopher A., additional, Maitra, Anirban, additional, Makinen, Netta, additional, Makowski, Danika, additional, Maley, Carlo, additional, Maliga, Zoltan, additional, Mallo, Diego, additional, Maris, John, additional, Markham, Nick, additional, Marks, Jeffrey, additional, Martinez, Daniel, additional, Mashl, Robert J., additional, Masilionais, Ignas, additional, Mason, Jennifer, additional, Massagué, Joan, additional, Massion, Pierre, additional, Mattar, Marissa, additional, Mazurchuk, Richard, additional, Mazutis, Linas, additional, McKinley, Eliot T., additional, McMichael, Joshua F., additional, Merrick, Daniel, additional, Meyerson, Matthew, additional, Miessner, Julia R., additional, Mills, Gordon B., additional, Mills, Meredith, additional, Mondal, Suman B., additional, Mori, Motomi, additional, Mori, Yuriko, additional, Moses, Elizabeth, additional, Mosse, Yael, additional, Muhlich, Jeremy L., additional, Murphy, George F., additional, Navin, Nicholas E., additional, Nederlof, Michel, additional, Ness, Reid, additional, Nevins, Stephanie, additional, Nikolov, Milen, additional, Nirmal, Ajit Johnson, additional, Nolan, Garry, additional, Novikov, Edward, additional, O’Connell, Brendan, additional, Offin, Michael, additional, Oh, Stephen T., additional, Olson, Anastasiya, additional, Ooms, Alex, additional, Ossandon, Miguel, additional, Owzar, Kouros, additional, Parmar, Swapnil, additional, Patel, Tasleema, additional, Patti, Gary J., additional, Pe'er, Itsik, additional, Peng, Tao, additional, Persson, Daniel, additional, Petty, Marvin, additional, Pfister, Hanspeter, additional, Polyak, Kornelia, additional, Pourfarhangi, Kamyar, additional, Puram, Sidharth V., additional, Qiu, Qi, additional, Quintanal-Villalonga, Álvaro, additional, Raj, Arjun, additional, Ramirez-Solano, Marisol, additional, Rashid, Rumana, additional, Reeb, Ashley N., additional, Reid, Mary, additional, Resnick, Adam, additional, Reynolds, Sheila M., additional, Riesterer, Jessica L., additional, Rodig, Scott, additional, Roland, Joseph T., additional, Rosenfield, Sonia, additional, Rotem, Asaf, additional, Roy, Sudipta, additional, Rozenblatt-Rosen, Orit, additional, Rudin, Charles M., additional, Ryser, Marc D., additional, Santi-Vicini, Maria, additional, Sato, Kazuhito, additional, Schrag, Deborah, additional, Schultz, Nikolaus, additional, Sears, Cynthia L., additional, Sears, Rosalie C., additional, Sen, Subrata, additional, Sen, Triparna, additional, Shalek, Alex, additional, Sheng, Jeff, additional, Sheng, Quanhu, additional, Shoghi, Kooresh I., additional, Shrubsole, Martha J., additional, Shyr, Yu, additional, Sibley, Alexander B., additional, Siex, Kiara, additional, Simmons, Alan J., additional, Singer, Dinah S., additional, Sivagnanam, Shamilene, additional, Slyper, Michal, additional, Sokolov, Artem, additional, Song, Sheng-Kwei, additional, Southard-Smith, Austin, additional, Spira, Avrum, additional, Stein, Janet, additional, Storm, Phillip, additional, Stover, Elizabeth, additional, Strand, Siri H., additional, Su, Timothy, additional, Sudar, Damir, additional, Sullivan, Ryan, additional, Surrey, Lea, additional, Suvà, Mario, additional, Terekhanova, Nadezhda V., additional, Ternes, Luke, additional, Thammavong, Lisa, additional, Thibault, Guillaume, additional, Thomas, George V., additional, Thorsson, Vésteinn, additional, Todres, Ellen, additional, Tran, Linh, additional, Tyler, Madison, additional, Uzun, Yasin, additional, Vachani, Anil, additional, Van Allen, Eliezer, additional, Vandekar, Simon, additional, Veis, Deborah J., additional, Vigneau, Sébastien, additional, Vossough, Arastoo, additional, Waanders, Angela, additional, Wagle, Nikhil, additional, Wang, Liang-Bo, additional, Wendl, Michael C., additional, West, Robert, additional, Wu, Chi-yun, additional, Wu, Hao, additional, Wu, Hung-Yi, additional, Wyczalkowski, Matthew A., additional, Xie, Yubin, additional, Yang, Xiaolu, additional, Yapp, Clarence, additional, Yu, Wenbao, additional, Yuan, Yinyin, additional, Zhang, Dadong, additional, Zhang, Kun, additional, Zhang, Mianlei, additional, Zhang, Nancy, additional, Zhang, Yantian, additional, Zhao, Yanyan, additional, Zhou, Daniel Cui, additional, Zhou, Zilu, additional, Zhu, Houxiang, additional, Zhu, Qin, additional, Zhu, Xiangzhu, additional, Zhu, Yuankun, additional, and Zhuang, Xiaowei, additional

Published
2020
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