41 results on '"Betzi, Stéphane"'
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2. ChemoDOTS: a web server to design chemistry-driven focused libraries
3. 4’-Ethynyl-2’-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress
4. Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes*
5. From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia
6. Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach
7. CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation
8. Functional Consequence of Covalent Reaction of Phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA)
9. CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation
10. Protein-Protein Interaction Inhibition (2P2I) Combining High Throughput and Virtual Screening: Application to the HIV-1 Nef Protein
11. Discovery of small molecule inhibitors of the PTK7/β-catenin inter-action targeting the Wnt signaling pathway in colorectal cancer
12. Revisiting the molecular interactions between the tumor protein TCTP and the drugs sertraline/thioridazine.
13. An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity
14. Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step
15. Focused chemical libraries – design and enrichment: an example of protein–protein interaction chemical space
16. In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor
17. 2P2Idb: a structural database dedicated to orthosteric modulation of protein–protein interactions
18. Revisiting the Molecular Interactions between the Tumor Protein TCTP and the Drugs Sertraline/Thioridazine.
19. In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor
20. Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis
21. Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach
22. Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining
23. Author response: Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining
24. Protein–Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery
25. Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins
26. 2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions
27. Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)
28. Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer
29. Crystal Structure of the Vaccinia Virus DNA Polymerase Holoenzyme Subunit D4 in Complex with the A20 N-Terminal Domain
30. Prevalence, Specificity and Determinants of Lipid-Interacting PDZ Domains from an In-Cell Screen and In Vitro Binding Experiments
31. Stereoselective synthesis of original spirolactams displaying promising folded structures
32. 2P2Idb: a structural database dedicated to orthosteric modulation of protein–protein interactions
33. GFscore: A General Nonlinear Consensus Scoring Function for High-Throughput Docking
34. Prevalence, Specificity and Determinants of Lipid-Interacting PDZ Domains from an In-Cell Screen and In Vitro Binding Experiments.
35. Comparative Virtual and Experimental Medium Throughput Screening for Hepatitis C Virus Polymerase Inhibitors
36. Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer
37. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer
38. CRCM5484: A BET- BDII Selective Compound With Differential Anti-Leukemic Drug Modulation
39. 4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
40. Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.
41. Protein-protein interaction inhibition (2P2I): fewer and fewer undruggable targets.
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