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20 results on '"Beukers, Ruud"'

1. Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients

Author

Simsek, Melek, Meijer, Berrie, Ramsoekh, Dewkoemar, Bouma, Gerd, van der Wouden, Egbert-Jan, den Hartog, Bert, de Vries, Annemarie C., Hoentjen, Frank, Dijkstra, Gerard, de Boer, Sybrand Y., Jansen, Jeroen M., van der Meulen, Andrea E., Beukers, Ruud, Brink, Menno A., Steinhauser, Toos, Oldenburg, Bas, Gilissen, Lennard P., Naber, Ton H., Verhagen, Marc A., de Boer, Nanne K.H., and Mulder, Chris J.J.

Published
2019
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2. Effect of Cognitive Behavioral Therapy on Clinical Disease Course in Adolescents and Young Adults With Inflammatory Bowel Disease and Subclinical Anxiety and/or Depression: Results of a Randomized Trial

Author

van den Brink, Gertrude, Stapersma, Luuk, Bom, Anna Sophia, Rizopolous, Dimitris, van der Woude, C Janneke, Stuyt, Rogier J L, Hendriks, Danielle M, van der Burg, Joyce A T, Beukers, Ruud, Korpershoek, Thea A, Theuns-Valks, Sabine D M, Utens, Elisabeth M W J, and Escher, Johanna C

Published
2019
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4. Health outcomes of 1000 children born to mothers with inflammatory bowel disease in their first 5 years of life

Author

Kanis, Shannon Linda, primary, Modderman, Sanne, additional, Escher, Johanna C, additional, Erler, Nicole, additional, Beukers, Ruud, additional, de Boer, Nanne, additional, Bodelier, Alexander, additional, Depla, Annekatrien C T.M, additional, Dijkstra, Gerard, additional, van Dijk, Anne-Baue Ruth Margaretha, additional, Gilissen, Lennard, additional, Hoentjen, Frank, additional, Jansen, Jeroen M, additional, Kuyvenhoven, Johan, additional, Mahmmod, Nofel, additional, Mallant-Hent, Rosalie C, additional, van der Meulen-de Jong, Andrea E, additional, Noruzi, Anahita, additional, Oldenburg, Bas, additional, Oostenbrug, Liekele E, additional, Ter Borg, Pieter C.J., additional, Pierik, Marieke, additional, Romberg- Camps, Mariëlle, additional, Thijs, Willem, additional, West, Rachel, additional, de Lima, Alison, additional, and van der Woude, C Janneke, additional

Published
2020
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5. Health outcomes of 1000 children born to mothers with inflammatory bowel disease in their first 5 years of life.

Author

Kanis, Shannon Linda, Modderman, Sanne, Escher, Johanna C., Erler, Nicole, Beukers, Ruud, de Boer, Nanne, Bodelier, Alexander, Depla, Annekatrien C. T. M., Dijkstra, Gerard, van Dijk, Anne-Baue Ruth Margaretha, Gilissen, Lennard, Hoentjen, Frank, Jansen, Jeroen M., Kuyvenhoven, Johan, Mahmmod, Nofel, Mallant-Hent, Rosalie C., van der Meulen-de, Andrea E., Noruzi, Anahita, Oldenburg, Bas, and Oostenbrug, Liekele E.

Subjects
INFLAMMATORY bowel diseases, MOTHER-child relationship, IMMUNIZATION of children, TYPE 1 diabetes, SMALL for gestational age, LOW birth weight, PEDIATRIC gastroenterology
Published
2021
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6. Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients

Author

MS MDL 1, Infection & Immunity, Simsek, Melek, Meijer, Berrie, Ramsoekh, Dewkoemar, Bouma, Gerd, van der Wouden, Egbert-Jan, den Hartog, Bert, de Vries, Annemarie C, Hoentjen, Frank, Dijkstra, Gerard, de Boer, Sybrand Y, Jansen, Jeroen M, van der Meulen, Andrea E, Beukers, Ruud, Brink, Menno A, Steinhauser, Toos, Oldenburg, Bas, Gilissen, Lennard P, Naber, Ton H, Verhagen, Marc A, de Boer, Nanne K H, Mulder, Chris J J, Dutch Initiative on Crohn and Colitis (ICC), MS MDL 1, Infection & Immunity, Simsek, Melek, Meijer, Berrie, Ramsoekh, Dewkoemar, Bouma, Gerd, van der Wouden, Egbert-Jan, den Hartog, Bert, de Vries, Annemarie C, Hoentjen, Frank, Dijkstra, Gerard, de Boer, Sybrand Y, Jansen, Jeroen M, van der Meulen, Andrea E, Beukers, Ruud, Brink, Menno A, Steinhauser, Toos, Oldenburg, Bas, Gilissen, Lennard P, Naber, Ton H, Verhagen, Marc A, de Boer, Nanne K H, Mulder, Chris J J, and Dutch Initiative on Crohn and Colitis (ICC)

Published
2019

7. Effectiveness of Disease-Specific Cognitive Behavioral Therapy on Anxiety, Depression, and Quality of Life in Youth With Inflammatory Bowel Disease: A Randomized Controlled Trial

Author

Stapersma, Luuk, primary, van den Brink, Gertrude, additional, van der Ende, Jan, additional, Szigethy, Eva M, additional, Beukers, Ruud, additional, Korpershoek, Thea A, additional, Theuns-Valks, Sabine D M, additional, Hillegers, Manon H J, additional, Escher, Johanna C, additional, and Utens, Elisabeth M W J, additional

Published
2018
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8. Phenotype of Inflammatory Bowel Disease at Diagnosis in the Netherlands

Author

Nuij, Veerle, Zelinkova, Zuzana, Rijk, Marno, Beukers, Ruud, Ouwendijk, Rob, Quispel, Rutger, van Tilburg, Antonie, Tang, Thjon, Smalbraak, Hermen, Bruin, Karlien, Lindenburg, Flordeliz, Peyrin-Biroulet, Laurent, Van Der Woude, C. Janneke, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Gastroenterology and Hepatology [Amphia Hospital], Amphia Hospital Breda, Department of Gastroenterology and Hepatology [Albert Schweitzer Hospital], Albert Schweitzer Hospital, Department of Gastroenterology and Hepatology [Ikazia Hospital], IkaziaHospital Rotterdam, Department of Gastroenterology and Hepatology [Reinier de Graaf Gasthuis], Reinier de Graaf Gasthuis, Department of Gastroenterology and Hepatology [Sint Franciscus Gasthuis], Sint Franciscus Gasthuis, Department of Gastroenterology and Hepatology [IJsselland Hospital], IJsselland Hospital, Department of Internal Medicine [Lievensberg Hospital], Lievensberg Hospital, Department of Gastroenterology and Hepatology [Tweesteden Hospital], Tweesteden Hospital, Department of Gastroenterology and Hepatology [Franciscus Hospital], Franciscus Hospital, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)

Subjects
Crohn’s disease, IBD unclassified, inflammatory bowel disease, [SDV]Life Sciences [q-bio], Delta cohort, population based, ulcerative colitis
Abstract

International audience; BackgroundTo describe the clinical characteristics of inflammatory bowel disease (IBD) at diagnosis in The Netherlands at the population level in the era of biologics.MethodsAll patients with newly diagnosed IBD (diagnosis made between January 1, 2006 and January 1, 2007) followed in 9 general hospitals in the southwest of the Netherlands were included in this population-based inception cohort study.ResultsA total of 413 patients were enrolled, of which 201 Crohn’s disease (CD) (48.7%), 188 ulcerative colitis (UC) (45.5%), and 24 IBD unclassified (5.8%), with a median age of 38 years (range, 14–95). Seventy-eight patients with CD (38.8%) had ileocolonic disease and 73 patients (36.3%) had pure colonic disease. In 8 patients (4.0%), the upper gastrointestinal tract was involved. Nineteen patients with CD (9.5%) had perianal disease. Thirty-nine patients with CD (19.4%) had stricturing phenotype. Of the patients with UC and IBDU, 39 (18.4%) suffered from pancolitis and 61 (29%) from proctitis. Severe endoscopic lesions at diagnosis were seen in 119 patients (28.8%, 68 CD, 49 UC, and 2 IBDU), whereas 98 patients (23.7%) had severe histological disease activity. Thirteen patients (3.1%, 10 CD and 3 UC) had extraintestinal manifestations at diagnosis. Twenty-three patients (5.6%, 20 CD and 3 UC) had fistula at diagnosis.ConclusionsIn this cohort, 31% of the patients with CD had complicated disease at diagnosis, 39% had ileocolonic disease, 9.5% had perianal disease, and in 4% the upper gastrointestinal tract was involved. Most patients with UC suffered from left-sided colitis (51%). Severe endoscopic lesions were reported in 34% of the patients with CD and 26% of the patients with UC. Three percent of the patients with IBD had extraintestinal manifestations.

Published
2013
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9. Sa1994 Long-Term Outcome of Children Born to IBD Mothers Preliminary Result From a Multicenter Retrospective Study in the Netherlands

Author

Kanis, Shannon L., primary, de Lima, Alison, additional, Zelinkova, Zuzana, additional, Dijkstra, Gerard, additional, West, Rachel, additional, Ouwendijk, Rob J., additional, de Boer, Nanne K., additional, van der Meulen - de Jong, Andrea E., additional, Pierik, Marie J., additional, Oostenbrug, Liekele E., additional, Romberg-Camps, Mariëlle, additional, Bodelier, Alexander, additional, Oldenburg, Bas, additional, Hoentjen, Frank, additional, Beukers, Ruud, additional, Jansen, Jeroen M., additional, and van der Woude, Christien J., additional

Published
2015
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11. Su1234 Microscopic Severity Is Related to Earlier Surgery in Newly Diagnosed CD Patients: Results From the DELTA Cohort

Author

Nuij, Veerle J., primary, Looman, Caspar W., additional, Rijk, Marno C., additional, Beukers, Ruud, additional, Ouwendijk, Rob J., additional, Quispel, Rutger, additional, van Tilburg, Antonie J.P., additional, Tang, Thjon, additional, Smalbraak, Hermen J., additional, Bruin, Karlien F, additional, Lindenburg, Flordeliz, additional, Peyrin-Biroulet, Laurent, additional, and van der Woude, Christien J., additional

Published
2013
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12. Tu1093 P53 Immunohistochemistry Differentiates Between Low-Grade Dysplasia and Regenerative Changes in Barrett's Esophagus

Author

Kastelein, Florine, primary, Spaander, Manon, additional, Biermann, Katharina, additional, Steyerberg, Ewout W, additional, Kalisvaart, Marit, additional, Walter, Laurens, additional, Stoop, Hans, additional, Beukers, Ruud, additional, Geldof, Han, additional, ter Borg, Pieter, additional, ter Borg, Frank, additional, Felt-Bersma, Richelle J., additional, van Tilburg, Antonie J.P., additional, Tan, Gie, additional, den Hartog, G(ijsbert), additional, Peters, Frans T., additional, Engels, Leopold G., additional, Kolkman, Jeroen J., additional, Kuipers, Ernst J., additional, and Bruno, Marco J., additional

Published
2012
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16. Benefit of Earlier Anti-TNF Treatment on IBD Disease Complications?

Author

Nuij, Veerle, Fuhler, Gwenny M., Edel, Annemarie J., Ouwendijk, Rob J. T., Rijk, Marno C. M., Beukers, Ruud, Quispel, Rutger, van Tilburg, Antonie J. P., Tang, Thjon J., Smalbraak, Hermen, Bruin, Karlien F., Lindenburg, Flordeliz, Peyrin-Biroulet, Laurent, and van der Woude, C. Janneke

Abstract

Background: Anti-tumour necrosis factor [anti-TNF] treatment was demonstrated to have disease-modifying abilities in inflammatory bowel disease [IBD]. In this study, we aimed to determine the effect of anti-TNF treatment timing on IBD disease complications and mucosal healing [MH]. Methods: The following IBD-related complications were tested in relation to timing of anti-TNF therapy start in newly diagnosed IBD patients [n = 413]: fistula formation, abscess formation, extraintestinal manifestations [EIM], surgery, referral to academic centre, and MH. Results: A total of 85 patients [21%] received anti-TNF (66 Crohn's disease [CD], 16 ulcerative colitis [UC], 3 inflammatory bowel disease unclassified [IBDU]) of whom 57% [48 patients] were treated < 16 months after diagnosis. Patients receiving anti-TNF early [< 16 months] did not differ from patients receiving anti-TNF late [> 16 months] regarding gender, age, smoking status, and familial IBD. More importantly, patients receiving anti-TNF early did not suffer less IBD-related complications during followup as compared with patients started on anti-TNF late, nor was more MH observed. Similar results were obtained when anti-TNF treated patient were stratified more stringently, ie < 12 months [40 patients] vs >2 4 months [24 patients]. Cox regression analysis showed no beneficial correlations between anti-TNF timing and IBD-related complications. Anti-TNF treated patients achieving MH were 11 times less likely to develop EIMs compared with patients who did not achieved MH while on anti-TNF. Conclusions: This study was unable to confirm a benefit of earlier anti-TNF treatment on IBD disease complications. This could be explained by more aggressive treatment earlier in disease, resulting in fewer IBD complications. However, it seems more likely that inappropriate selection of patients for therapy leads to suboptimal treatment and subsequently suboptimal outcome. [ABSTRACT FROM AUTHOR]

Published
2015
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20. Phenotype of inflammatory bowel disease at diagnosis in the Netherlands: a population-based inception cohort study (the Delta Cohort).

Author

Nuij VJ, Zelinkova Z, Rijk MC, Beukers R, Ouwendijk RJ, Quispel R, van Tilburg AJ, Tang TJ, Smalbraak H, Bruin KF, Lindenburg F, Peyrin-Biroulet L, and van der Woude CJ

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Follow-Up Studies, Humans, Inflammatory Bowel Diseases complications, Inflammatory Bowel Diseases epidemiology, Intestinal Diseases drug therapy, Intestinal Diseases etiology, Male, Middle Aged, Netherlands epidemiology, Phenotype, Prognosis, Young Adult, Inflammatory Bowel Diseases diagnosis, Intestinal Diseases diagnosis
Abstract

Background: To describe the clinical characteristics of inflammatory bowel disease (IBD) at diagnosis in The Netherlands at the population level in the era of biologics., Methods: All patients with newly diagnosed IBD (diagnosis made between January 1, 2006 and January 1, 2007) followed in 9 general hospitals in the southwest of the Netherlands were included in this population-based inception cohort study., Results: A total of 413 patients were enrolled, of which 201 Crohn's disease (CD) (48.7%), 188 ulcerative colitis (UC) (45.5%), and 24 IBD unclassified (5.8%), with a median age of 38 years (range, 14-95). Seventy-eight patients with CD (38.8%) had ileocolonic disease and 73 patients (36.3%) had pure colonic disease. In 8 patients (4.0%), the upper gastrointestinal tract was involved. Nineteen patients with CD (9.5%) had perianal disease. Thirty-nine patients with CD (19.4%) had stricturing phenotype. Of the patients with UC and IBDU, 39 (18.4%) suffered from pancolitis and 61 (29%) from proctitis. Severe endoscopic lesions at diagnosis were seen in 119 patients (28.8%, 68 CD, 49 UC, and 2 IBDU), whereas 98 patients (23.7%) had severe histological disease activity. Thirteen patients (3.1%, 10 CD and 3 UC) had extraintestinal manifestations at diagnosis. Twenty-three patients (5.6%, 20 CD and 3 UC) had fistula at diagnosis., Conclusions: In this cohort, 31% of the patients with CD had complicated disease at diagnosis, 39% had ileocolonic disease, 9.5% had perianal disease, and in 4% the upper gastrointestinal tract was involved. Most patients with UC suffered from left-sided colitis (51%). Severe endoscopic lesions were reported in 34% of the patients with CD and 26% of the patients with UC. Three percent of the patients with IBD had extraintestinal manifestations.

Published
2013
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