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1. Susceptibility Vessel Sign and Intravenous Alteplase in Stroke Patients Treated with Thrombectomy: A Secondary Analysis of the SWIFT DIRECT Trial

Author

Beyeler, Morin, Rohner, Roman, Ijäs, Petra, Eker, Omer F., Cognard, Christophe, Bourcier, Romain, Sibon, Igor, Lefebvre, Margaux, Richard, Sébastien, Consoli, Arturo, Moulin, Solène, Ernst, Marielle, Ribo, Marc, Barbier, Charlotte, Nikoubashman, Omid, Liebeskind, David S., Goeldlin, Martina B., Piechowiak, Eike I., Bütikofer, Lukas, Gralla, Jan, Fischer, Urs, and Kaesmacher, Johannes

Published
2025
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3. Long-Term Effect of Mechanical Thrombectomy in Stroke Patients According to Advanced Imaging Characteristics.

Author

Beyeler, Morin, Pohle, Fabienne, Weber, Loris, Mueller, Madlaine, Kurmann, Christoph C., Mujanovic, Adnan, Clénin, Leander, Piechowiak, Eike Immo, Meinel, Thomas Raphael, Bücke, Philipp, Jung, Simon, Seiffge, David, Pilgram-Pastor, Sara M., Dobrocky, Tomas, Arnold, Marcel, Gralla, Jan, Fischer, Urs, Mordasini, Pasquale, and Kaesmacher, Johannes

Published
2024
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5. Mortality in acute ischemic stroke patients with new cancer diagnosed during the index hospitalization versus after discharge

Author

Göcmen, Jayan, Steinauer, Fabienne, Kielkopf, Moritz, Branca, Mattia, Kurmann, Christoph C., Mujanovic, Adnan, Clénin, Leander, Silimon, Norbert, Boronylo, Anna, Scutelnic, Adrian, Meinel, Thomas, Kaesmacher, Johannes, Bücke, Philipp, Seiffge, David, Costamagna, Gianluca, Michel, Patrik, Fischer, Urs, Arnold, Marcel, Navi, Babak B., Pabst, Thomas, Berger, Martin D., Jung, Simon, and Beyeler, Morin

Published
2024
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6. Factors impacting D-dimer levels in patients with acute ischemic cerebrovascular events

Author

Hacialioglu, Recep-Ali, Kielkopf, Moritz, Branca, Mattia, Clenin, Leander, Boronylo, Anna, Silimon, Norbert, Göldlin, Martina B., Scutelnic, Adrian, Kaesmacher, Johannes, Mujanovic, Adnan, Meinel, Thomas R., Seiffge, David J., Heldner, Mirjam R., Liberman, Ava L., Navi, Babak B., Fischer, Urs, Arnold, Marcel, Jung, Simon, Bücke, Philipp, and Beyeler, Morin

Published
2024
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9. Changes of migraine aura with advancing age of patients

Author

Scutelnic, Adrian, Drangova, Hristina, Klein, Antonia, Slavova, Nedelina, Beyeler, Morin, Lippert, Julian, Silimon, Norbert, Meinel, Thomas R., Arnold, Marcel, Fischer, Urs, Riederer, Franz, Mattle, Heinrich P., Jung, Simon, and Schankin, Christoph J.

Published
2023
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10. Association of Intravenous Thrombolysis with Delayed Reperfusion After Incomplete Mechanical Thrombectomy

Author

Mujanovic, Adnan, Kammer, Christoph, Kurmann, Christoph C., Grunder, Lorenz, Beyeler, Morin, Lang, Matthias F., Piechowiak, Eike I., Meinel, Thomas R., Jung, Simon, Almiri, William, Pilgram-Pastor, Sara, Hoffmann, Angelika, Seiffge, David J., Heldner, Mirjam R., Dobrocky, Tomas, Mordasini, Pasquale, Arnold, Marcel, Gralla, Jan, Fischer, Urs, and Kaesmacher, Johannes

Published
2023
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11. Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes

Author

Strambo, Davide, Marto, João Pedro, Ntaios, George, Nguyen, Thanh N., Michel, Patrik, Herzig, Roman, Członkowksa, Anna, Demeestere, Jelle, Yassin Mansour, Ossama, Georgiopoulos, Georgios, Nogueira, Raul G., Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W., Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Nuno Ramos, João, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Paiva-Nunes, Ana, Ferreira, Patrícia, Pinho-e-Melo, Teresa, Carvalho-Dias, Mariana, Paula, André, Alberto Correia, Manuel, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Nuno-Alves, José, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araújo, André, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Diamanti, Susanna, Beretta, Simone, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maier, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loic, Cuisenier, Pauline, Vodret, Francesca R., Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O., Hendrik Schaefer, Jan, Nolte, Christian H., Audebert, Heinrich, Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke-Ruth, Stolp, Jeffrey, Stolze, Lotte J., Coutinho, Jonathan M., Nederkoorn, Paul J., van-den-Wijngaard, Ido, de Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Pierre Rutgers, Matthieu, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, Gonzalez-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria-Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Pérez-Sánchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Perez de la Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernandez-Fernandez, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David J., Saxhaug Kristoffersen, Espen, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulík, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Kočí, Lubomír, Eichlová, Zuzana, Jíra, Martin, Kovář, Martin, Panský, Michal, Mencl, Pavel, Paloušková, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Šrámek, Martin, Havlíček, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karliński, Michał, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiącek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielińska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Sławomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Łabuz-Roszak, Beata, Dębiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena-Oana, Radu, Razvan-Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Özcan-Özdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ibrahim Ismail, Ismail, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada-A., Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenny, Khan, Muhib-A., Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham E., Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael, Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz-M., Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel A., Barrientos, José-Domingo, Caetano, Rayllene, Targa, Rodrigo, Scollo, Sergio, Yalung, Patrick, Nagendra, Shashank, Gaikwad, Abhijit, and Seo, Kwon-Duk

Published
2024
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13. Development of a Score for Prediction of Occult Malignancy in Stroke Patients (Occult-5 Score)

Author

Beyeler, Morin, Birner, Barbara, Branca, Mattia, Meinel, Thomas, Vynckier, Jan, Buffle, Eric, Scutelnic, Adrian, Heldner, Mirjam R., Bücke, Philipp, Seiffge, David, Mordasini, Pascale, Dobrocky, Tomas, Piechowiak, Eike I., Kaesmacher, Johannes, Gralla, Jan, Mattle, Heinrich P., Arnold, Marcel, Fischer, Urs, Pabst, Thomas, Berger, Martin D., and Jung, Simon

Published
2022
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14. Tranexamic Acid for Intracerebral Hemorrhage in Patients on Non-Vitamin K Antagonist Oral Anticoagulants (TICH-NOAC): A Multicenter, Randomized, Placebo-Controlled, Phase 2 Trial

Author

Polymeris, Alexandros A., Karwacki, Grzegorz M., Siepen, Bernhard M., Schaedelin, Sabine, Tsakiris, Dimitrios A., Stippich, Christoph, Guzman, Raphael, Nickel, Christian H., Sprigg, Nikola, Kägi, Georg, Vehoff, Jochen, Barinka, Filip, Thilemann, Sebastian, Maurer, Marina, Wagner, Benjamin, Traenka, Christopher, Gensicke, Henrik, De Marchis, Gian Marco, Bonati, Leo H., Fischer, Urs, Z’Graggen, Werner J., Nedeltchev, Krassen, Wegener, Susanne, Baumgartner, Philipp, Engelter, Stefan T., Seiffge, David J., Peters, Nils, Lyrer, Philippe A., Clarke, Sandra, Falcao, Martina, Avramiotis, Nikolaos S, Dittrich, Tolga, Fisch, Urs, Fladt, Joachim, Hert, Lisa, Schneider, Iris, Wiegert, Martina, Zietz, Annaelle, Beyeler, Morin, Goeldlin, Martina, Kormann, Marianne, Maamari, Basel, McEvoy, Liselotte, Meinel, Thomas R, Müller, Madlaina, Vynckier, Jan, Ardila, Elena, Feuerstein, Ingrid, Gantenbein, Claudine, Müller, Anna, Seljmani, Vjosa, Wagner, Benedikt, Anders, Bettina, Backhaus, Roland, Paliantonis, Asterios, Taheri, Shadi, Thumm, Dennis, van Duinen, Jannie, and Von Bieberstein, Lita

Published
2023
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17. Prevalence and Distribution of Intracranial Vessel Occlusion on Angiography and Its Association with Functional Outcome in Patients with Atrial Fibrillation Presenting with Ischemic Stroke.

Author

Benz, Alexander P., Meinel, Thomas R., Salerno, Alexander, Beyeler, Morin, Strambo, Davide, Kaesmacher, Johannes, Polymeris, Alexandros A., Kahles, Timo, Katan, Mira, Engelter, Stefan T., Carrera, Emmanuel, Dirren, Elisabeth, Peters, Nils, Cereda, Carlo W., Kägi, Georg, Renaud, Susanne, Wegener, Susanne, Bolognese, Manuel, Bonati, Leo H., and Fischer, Urs

Subjects
ISCHEMIC stroke, CEREBRAL circulation, ANTICOAGULANTS, ATRIAL fibrillation, COMPUTED tomography
Abstract

Objectives: To determine the prevalence and distribution of intracranial vessel occlusion identified on computed tomography (CT) or magnet resonance (MR) angiography and to explore its association with functional outcome in patients with atrial fibrillation (AF) and ischemic stroke. Methods: Multicenter cohort study enrolling consecutive patients with AF with imaging‐confirmed ischemic stroke who underwent CT‐ or MR‐angiography on admission (2014–2022). Multivariable regression was used to explore the association between intracranial vessel occlusion and poor functional outcome (modified Rankin Scale score 3–6) at 90 days. Results: The analysis included 10,164 patients (median age 81.5 years, 47.8% female, median National Institutes of Health Stroke Scale score on admission 6; 14.7% on a vitamin K antagonist [VKA], 27.5% on a direct oral anticoagulant [DOAC], 57.8% not receiving oral anticoagulation). Angiography showed intracranial vessel occlusion in 5,190 patients (51.1%), affecting the anterior cerebral circulation in 87.4%. Overall, 29.2% and 29.4% of patients received thrombolysis and mechanical thrombectomy, respectively. The proportion of patients with poor functional outcome at 90 days was 60.6% and 42.7% in those with and without vessel occlusion, respectively. In multivariable analyses, vessel occlusion was associated with poor functional outcome (adjusted odds ratio [aOR]: 1.95, 95% confidence interval [CI]: 1.71–2.22) with consistent results in subgroups according to oral anticoagulation use (VKA, aOR: 1.98, 95% CI: 1.40–2.80; DOAC, aOR: 2.35, 95% CI: 1.83–3.03; none, aOR: 1.76, 95% CI: 1.49–2.09). Interpretation: Intracranial vessel occlusion is common in patients with AF with ischemic stroke, mainly affects the anterior circulation and is associated with poor functional outcome. ANN NEUROL 2024;96:1115–1123 [ABSTRACT FROM AUTHOR]

Published
2024
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19. Susceptibility vessel sign, a predictor of long-term outcome in patients with stroke treated with mechanical thrombectomy.

Author

Beyeler, Morin, Rea, Erich, Weber, Loris, Belachew, Nebiyat Filate, Aleman, Enrique Barvulsky, Kielkopf, Moritz, Kurmann, Christoph C., Grunder, Lorenz, Piechowiak, Eike Immo I., Meinel, Thomas R., Heldner, Mirjam R., Seiffge, David, Pilgram-Pastor, Sara, Dobrocky, Tomas, Pabst, Thomas, Berger, Martin D., Jung, Simon, Arnold, Marcel, Gralla, Jan, and Fischer, Urs

Subjects
STROKE-related mortality, STROKE prognosis, DIABETES complications, PREDICTIVE tests, RESEARCH funding, LOGISTIC regression analysis, TREATMENT effectiveness, MAGNETIC resonance imaging, RETROSPECTIVE studies, FUNCTIONAL status, DESCRIPTIVE statistics, ODDS ratio, MEDICAL records, ACQUISITION of data, STROKE, THROMBECTOMY, NEURORADIOLOGY, CONFIDENCE intervals, TUMORS, BIOMARKERS, PROPORTIONAL hazards models, TIME, DISEASE complications
Abstract

Background The absence of the susceptibility vessel sign (SVS) in patients treated with mechanical thrombectomy (MT) is associated with poor radiological and clinical outcomes after 3 months. Underlying conditions, such as cancer, are assumed to influence SVS status and could potentially impact the long-term outcome. We aimed to assess SVS status as an independent predictor of long-term outcomes in MT-treated patients. Methods SVS status was retrospectively determined in consecutive MT-treated patients at a comprehensive stroke center between 2010 and 2018. Predictors of long-term mortality and poor functional outcome (modified Rankin Scale (mRS) ≥3) up to 8 years were identified using multivariable Cox and logistic regression, respectively. Results Of the 558 patients included, SVS was absent in 13% (n=71) and present in 87% (n=487) on baseline imaging. Patients without SVS were more likely to have active cancer (P=0.003) and diabetes mellitus (P<0.001) at the time of stroke. The median long-term follow-up time was 1058 days (IQR 533-1671 days). After adjustment for active cancer and diabetes mellitus, among others, the absence of SVS was associated with long-term mortality (adjusted HR (aHR) 2.11, 95% CI 1.35 to 3.29) and poor functional outcome in the long term (adjusted OR (aOR) 2.90, 95% CI 1.29 to 6.55). Conclusion MT-treated patients without SVS have higher long-term mortality rates and poorer long-term functional outcome. It appears that this association cannot be explained by comorbidities alone, and further studies are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Uptake of Dual Antiplatelet Therapy After High-Risk Transient Ischemic Attack at a University Hospital

Author

Beyeler, Morin, Bücke, Philipp, Castigliego, Pasquale, Baumann, Joel, Ziegler, Victor, Navi, Babak B., Jung, Simon, Arnold, Marcel, and Liberman, Ava L.

Abstract

Multiple randomized controlled trials have demonstrated that dual antiplatelet therapy (DAPT) significantly reduces the risk of subsequent stroke as compared to aspirin monotherapy after high-risk transient ischemic attack (TIA) or minor ischemic stroke. We sought to evaluate the uptake of DAPT after high-risk TIA at a single center. We conducted a retrospective cohort study of consecutive TIA patients admitted via the Emergency Department (ED) of Bern University Hospital (1/1/2018-12/31/2019). We use descriptive statistics to detail cohort characteristics and compared patients treated with DAPT to those not treated. Statistical significance was set at α = 0.05 and all tests of comparison were two-sided. A total of 383 TIA patients were seen during the study period, 247 were eligible for DAPT. Among those eligible for DAPT, mean age was 72 years and 51% were female. A total of 49 (19.8%) eligible TIA patients were treated with DAPT; use of DAPT significantly increased from 2018 to 2019. Patients admitted to the stroke unit or intensive care unit (n = 33) had a significantly higher proportion of DAPT treatment as compared to those admitted to the general neurology ward or discharged to home from the ED. DAPT use was also significantly higher in patients with large artery atherosclerotic disease (n = 23) as compared to other etiological subtypes and significantly higher among patients who arrived to the ED within 24 h of symptom onset (n = 178). In conclusion, we found that only 2 out of every 10 high-risk TIA patients received DAPT in the years following its introduction in the clinical practice. Our results suggest that strategies to improve the uptake of new, evidence-based secondary stroke prevention treatment after high-risk TIA are needed.

Published
2025
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22. Prevalence and Distribution of Intracranial Vessel Occlusion on Angiography and Its Association with Functional Outcome in Patients with Atrial Fibrillation Presenting with Ischemic Stroke

Author

Benz, Alexander P; https://orcid.org/0000-0003-2555-1266, Meinel, Thomas R; https://orcid.org/0000-0002-0647-9273, Salerno, Alexander; https://orcid.org/0000-0001-8494-5527, Beyeler, Morin, Strambo, Davide, Kaesmacher, Johannes, Polymeris, Alexandros A; https://orcid.org/0000-0002-9475-2208, Kahles, Timo, Katan, Mira; https://orcid.org/0000-0002-9265-8066, Engelter, Stefan T, Carrera, Emmanuel; https://orcid.org/0000-0003-0045-5382, Dirren, Elisabeth, Peters, Nils; https://orcid.org/0000-0001-8451-7389, Cereda, Carlo W; https://orcid.org/0000-0002-6479-1476, Kägi, Georg, Renaud, Susanne, Wegener, Susanne; https://orcid.org/0000-0003-4369-7023, Bolognese, Manuel, Bonati, Leo H, Fischer, Urs, Arnold, Marcel, Michel, Patrik, Shoamanesh, Ashkan; https://orcid.org/0000-0002-2802-1626, Connolly, Stuart J, Seiffge, David J; https://orcid.org/0000-0003-3890-3849, Benz, Alexander P; https://orcid.org/0000-0003-2555-1266, Meinel, Thomas R; https://orcid.org/0000-0002-0647-9273, Salerno, Alexander; https://orcid.org/0000-0001-8494-5527, Beyeler, Morin, Strambo, Davide, Kaesmacher, Johannes, Polymeris, Alexandros A; https://orcid.org/0000-0002-9475-2208, Kahles, Timo, Katan, Mira; https://orcid.org/0000-0002-9265-8066, Engelter, Stefan T, Carrera, Emmanuel; https://orcid.org/0000-0003-0045-5382, Dirren, Elisabeth, Peters, Nils; https://orcid.org/0000-0001-8451-7389, Cereda, Carlo W; https://orcid.org/0000-0002-6479-1476, Kägi, Georg, Renaud, Susanne, Wegener, Susanne; https://orcid.org/0000-0003-4369-7023, Bolognese, Manuel, Bonati, Leo H, Fischer, Urs, Arnold, Marcel, Michel, Patrik, Shoamanesh, Ashkan; https://orcid.org/0000-0002-2802-1626, Connolly, Stuart J, and Seiffge, David J; https://orcid.org/0000-0003-3890-3849

Abstract

Objectives To determine the prevalence and distribution of intracranial vessel occlusion identified on computed tomography (CT) or magnet resonance (MR) angiography and to explore its association with functional outcome in patients with atrial fibrillation (AF) and ischemic stroke. Methods Multicenter cohort study enrolling consecutive patients with AF with imaging‐confirmed ischemic stroke who underwent CT‐ or MR‐angiography on admission (2014–2022). Multivariable regression was used to explore the association between intracranial vessel occlusion and poor functional outcome (modified Rankin Scale score 3–6) at 90 days. Results The analysis included 10,164 patients (median age 81.5 years, 47.8% female, median National Institutes of Health Stroke Scale score on admission 6; 14.7% on a vitamin K antagonist [VKA], 27.5% on a direct oral anticoagulant [DOAC], 57.8% not receiving oral anticoagulation). Angiography showed intracranial vessel occlusion in 5,190 patients (51.1%), affecting the anterior cerebral circulation in 87.4%. Overall, 29.2% and 29.4% of patients received thrombolysis and mechanical thrombectomy, respectively. The proportion of patients with poor functional outcome at 90 days was 60.6% and 42.7% in those with and without vessel occlusion, respectively. In multivariable analyses, vessel occlusion was associated with poor functional outcome (adjusted odds ratio [aOR]: 1.95, 95% confidence interval [CI]: 1.71–2.22) with consistent results in subgroups according to oral anticoagulation use (VKA, aOR: 1.98, 95% CI: 1.40–2.80; DOAC, aOR: 2.35, 95% CI: 1.83–3.03; none, aOR: 1.76, 95% CI: 1.49–2.09). Interpretation Intracranial vessel occlusion is common in patients with AF with ischemic stroke, mainly affects the anterior circulation and is associated with poor functional outcome.

Published
2024

23. Frequency of ischaemic stroke and intracranial haemorrhage in patients with reversible cerebral vasoconstriction syndrome (RCVS) and posterior reversible encephalopathy syndrome (PRES) – A systematic review

Author

Kaufmann, Jana, primary, Buecke, Philipp, additional, Meinel, Thomas, additional, Beyeler, Morin, additional, Scutelnic, Adrian, additional, Kaesmacher, Johannes, additional, Mujanović, Adnan, additional, Dobrocky, Thomas, additional, Arsany, Hakim, additional, Peters, Nils, additional, Z'Graggen, Werner, additional, Jung, Simon, additional, and Seiffge, David, additional

Published
2024
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25. Abstract TP225: Prevalence of Patent Foramen Ovale in Patients With Cancer-Related Stroke

Author

Steinauer, Fabienne, primary, Bücke, Philipp, additional, Göcmen, Jayan, additional, Mujanovic, Adnan, additional, Kaesmacher, Johannes, additional, Meinel, Thomas, additional, Seiffge, David, additional, Buffle, Eric, additional, Navi, Babak, additional, Fischer, Urs, additional, Arnold, Marcel, additional, Pabst, Thomas, additional, Berger, Martin, additional, Jung, Simon, additional, and Beyeler, Morin, additional

Published
2024
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26. Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke: A Post Hoc Analysis of the ARCADIA Randomized Clinical Trial.

Author

Navi, Babak B., Zhang, Cenai, Miller, Benjamin, Cushman, Mary, Kasner, Scott E., Elkind, Mitchell S. V., Tirschwell, David L., Longstreth Jr, W. T., Kronmal, Richard A., Beyeler, Morin, Elm, Jordan, Zweifler, Richard M., Tarsia, Joseph, Cereda, Carlo W., Bianco, Giovanni, Costamagna, Gianluca, Michel, Patrik, Broderick, Joseph P., Gladstone, David J., and Kamel, Hooman

Published
2024
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27. Ischemic Stroke in Cancer: Mechanisms, Biomarkers, and Implications for Treatment.

Author

Costamagna, Gianluca, Navi, Babak B., Beyeler, Morin, Hottinger, Andreas F., Alberio, Lorenzo, and Michel, Patrik

Subjects
ISCHEMIC stroke, CANCER-related mortality, CELL-free DNA, FIBRINOLYTIC agents, EXTRACELLULAR vesicles, CANCER fatigue
Abstract

Ischemic stroke is an important cause of morbidity and mortality in cancer patients. The underlying mechanisms linking cancer and stroke are not completely understood. Long-standing and more recent evidence suggests that cancer-associated prothrombotic states, along with treatment-related vascular toxicity, such as with chemotherapy and immunotherapy, contribute to an increased risk of ischemic stroke in cancer patients. Novel biomarkers, including coagulation, platelet and endothelial markers, cell-free DNA, and extracellular vesicles are being investigated for their potential to improve risk stratification and patient selection for clinical trials and to help guide personalized antithrombotic strategies. Treatment of cancer-related stroke poses unique challenges, including the need to balance the risk of recurrent stroke and other thromboembolic events with that of bleeding associated with antithrombotic therapy. In addition, how and when to restart cancer treatment after stroke remains unclear. In this review, we summarize current knowledge on the mechanisms underlying ischemic stroke in cancer, propose an etiological classification system unique to cancer-related stroke to help guide patient characterization, provide an overview of promising biomarkers and their clinical utility, and discuss the current state of evidence-based management strategies for cancer-related stroke. Ultimately, a personalized approach to stroke prevention and treatment is required in cancer patients, considering both the underlying cancer biology and the individual patient's risk profile. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Transient ischemic attacks in patients with active and occult cancer

Author

Beyeler, Morin, primary, Castigliego, Pasquale, additional, Baumann, Joel, additional, Ziegler, Victor, additional, Kielkopf, Moritz, additional, Mueller, Madlaine, additional, Bauer-Gambelli, Stefan A., additional, Mujanovic, Adnan, additional, Meinel, Thomas Raphael, additional, Horvath, Thomas, additional, Fischer, Urs, additional, Kaesmacher, Johannes, additional, Heldner, Mirjam R., additional, Seiffge, David, additional, Arnold, Marcel, additional, Pabst, Thomas, additional, Berger, Martin D., additional, Navi, Babak B., additional, Jung, Simon, additional, and Bücke, Philipp, additional

Published
2023
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29. Long-Term Effect of Mechanical Thrombectomy in Stroke Patients According to Advanced Imaging Characteristics.

Author

Beyeler, Morin, primary, Pohle, Fabienne, additional, Weber, Loris, additional, Mueller, Madlaine, additional, Kurmann, Christoph C., additional, Mujanovic, Adnan, additional, Clénin, Leander, additional, Piechowiak, Eike Immo, additional, Meinel, Thomas Raphael, additional, Bücke, Philipp, additional, Jung, Simon, additional, Seiffge, David, additional, Pilgram-Pastor, Sara M., additional, Dobrocky, Tomas, additional, Arnold, Marcel, additional, Gralla, Jan, additional, Fischer, Urs, additional, Mordasini, Pasquale, additional, and Kaesmacher, Johannes, additional

Published
2023
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30. Intravenous Thrombolysis With or Without Endovascular Treatment for Suspected Ischemic Stroke in Patients With Intracranial Tumors

Author

Seystahl, Katharina, primary, Martinez-Majander, Nicolas, additional, Salerno, Alexander, additional, Beyeler, Morin, additional, Erdur, Hebun, additional, Marto, João Pedro, additional, Hametner, Christian, additional, Zedde, Marialuisa, additional, Pezzini, Alessandro, additional, Leker, Ronen, additional, Altersberger, Valerian, additional, Costamagna, Gianluca, additional, Serôdio, Miguel, additional, Migliaccio, Ludovica, additional, Pascarella, Rosario, additional, Zini, Andrea, additional, Mannismäki, Laura, additional, Béjot, Yannick, additional, Jung, Simon, additional, Gensicke, Henrik, additional, Padjen, Visnja, additional, Ringleb, Peter A., additional, Nolte, Christian, additional, Heldner, Mirjam R, additional, Michel, Patrik, additional, Engelter, Stefan T., additional, Curtze, Sami, additional, Weller, Michael, additional, and Wegener, Susanne, additional

Published
2023
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31. Chronic cerebral infarctions and white matter lesions link to long‐term survival after a first ischemic event: A cohort study

Author

Schilter, Marina, Epstein, Alessandra, Vynckier, Jan, Mujanovic, Adnan, Belachew, Nebiyat Filate, Beyeler, Morin, Siepen, Bernhard, Goeldlin, Martina, Scutelnic, Adrian, Seiffge, David Julian, Jung, Simon, Gralla, Jan, Dobrocky, Tomas, Arnold, Marcel, Kaesmacher, Johannes, Fischer, Urs, and Meinel, Thomas Raphael

Subjects
Male, Leukoaraiosis, 610 Medicine & health, Cerebral Infarction, White Matter, Magnetic Resonance Imaging, Brain Ischemia, Stroke, Cohort Studies, Ischemic Attack, Transient, Humans, Female, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Ischemic Stroke
Abstract

BACKGROUND AND PURPOSE To investigate the association of different phenotypes, count, and locations of chronic covert brain infarctions (CBI) with long-term mortality in patients with first-ever manifest acute ischemic stroke (AIS) or transient ischemic attack (TIA). Additionally, to analyze their potential interaction with white matter hyperintensities (WMH) and predictive value in addition to established mortality scores. METHODS Single-center cohort study including consecutive patients with first-ever AIS or TIA with available MRI imaging from January 2015 to December 2017. Blinded raters adjudicated CBI phenotypes and WMH (age-related white matter changes score) according to established definitions. We compared Cox regression models including prespecified established predictors of mortality using Harrell's C and likelihood ratio tests. RESULTS A total of 2236 patients (median [interquartile range] age: 71 [59-80] years, 43% female, National Institutes of Health Stroke Scale: 2 [1-6], median follow-up: 1436 days, 21% death during follow-up) were included. Increasing WMH (per point adjusted Hazard Ratio [aHR] = 1.29 [1.14-1.45]), but not CBI (aHR = 1.21 [0.99-1.49]), were independently associated with mortality. Neither CBI phenotype, count, nor location was associated with mortality and there was no multiplicative interaction between CBI and WMH (p > .1). As compared to patients without CBI or WMH, patients with moderate or severe WMH and additional CBI had the highest hazards of death (aHR = 1.62 [1.23-2.13]). The Cox regression model including CBI and WMH had a small but significant increment in Harrell's C when compared to the model including 14 clinical variables (0.831 vs. 0.827, p

Published
2022
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32. Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up

Author

Society of Vascular and Interventional Neurology (US), Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Vanguru, Husitha Reddy, Lesaine, Emilie, Tsivgoulis, Georgios, Loochtan, Aaron I., Demeestere, Jelle, Uchino, Ken, Inoa, Violiza, Goyal, Nitin, Charidimou, Andreas, Siegler, James E., Yaghi, Shadi, Aguiar de Sousa, Diana, Mohammaden, Mahmoud H., Haussen, Diogo C., Kristoffersen, Espen Saxhaug, Lereis, Virginia Pujol, Scollo, Sergio Daniel, Campbell, Bruce C. V., Ma, Alice, Thomas, James Orton, Parsons, Mark W., Singhal, Shaloo, Slater, Lee-Anne, Tomazini Martins, Rodrigo, Enzinger, Chris, Gattringer, Thomas, Rahman, Aminur, Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C. T., Neves, Luciana de Oliveira, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Silva, Isabelle Lameirinhas da, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Ángel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Nolte, Christian H, Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, José Domingo, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P. N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Coutinho, Jonathan M, Rinkel, Leon A., Dippel, Diederik W. J., Dam-Nolen, Dianne H. K. van, Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Pérez-Sánchez, Soledad, García Sánchez, María Jesús, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T. P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ã-Zcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutiérrez, Santiago, Puri, Ajit S, Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, José Rafael, Rost, Natalia S., Rothstein, Aaron, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., Nogueira, Raul G., Society of Vascular and Interventional Neurology (US), Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Vanguru, Husitha Reddy, Lesaine, Emilie, Tsivgoulis, Georgios, Loochtan, Aaron I., Demeestere, Jelle, Uchino, Ken, Inoa, Violiza, Goyal, Nitin, Charidimou, Andreas, Siegler, James E., Yaghi, Shadi, Aguiar de Sousa, Diana, Mohammaden, Mahmoud H., Haussen, Diogo C., Kristoffersen, Espen Saxhaug, Lereis, Virginia Pujol, Scollo, Sergio Daniel, Campbell, Bruce C. V., Ma, Alice, Thomas, James Orton, Parsons, Mark W., Singhal, Shaloo, Slater, Lee-Anne, Tomazini Martins, Rodrigo, Enzinger, Chris, Gattringer, Thomas, Rahman, Aminur, Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C. T., Neves, Luciana de Oliveira, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Silva, Isabelle Lameirinhas da, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Ángel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Nolte, Christian H, Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, José Domingo, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P. N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Coutinho, Jonathan M, Rinkel, Leon A., Dippel, Diederik W. J., Dam-Nolen, Dianne H. K. van, Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Pérez-Sánchez, Soledad, García Sánchez, María Jesús, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T. P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ã-Zcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutiérrez, Santiago, Puri, Ajit S, Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, José Rafael, Rost, Natalia S., Rothstein, Aaron, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., and Nogueira, Raul G.

Abstract

Background and Objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020)., Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases., Results: There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1–6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1–4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4–5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6–0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31–1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82–2.97], 5,656/195,539) of all stroke hospitalizations., Discussion: There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year., Trial Registration Information: This study is registered under NCT04934020.

Published
2023

33. Absence of susceptibility vessel sign and hyperdense vessel sign in patients with cancer-related stroke

Author

Beyeler, Morin, Grunder, Lorenz, Göcmen, Jayan, Steinauer, Fabienne, Belachew, Nebiyat F, Kielkopf, Moritz, Clénin, Leander, Mueller, Madlaine, Silimon, Norbert, Kurmann, Christoph, Meinel, Thomas, Bücke, Philipp, Seiffge, David Julian, Dobrocky, Tomas, Piechowiak, Eike I, Pilgram-Pastor, Sara, Mattle, Heinrich P, Navi, Babak B, Arnold, Marcel, Fischer, Urs, Pabst, Thomas, Gralla, Jan, Berger, Martin D, Jung, Simon, and Kaesmacher, Johannes

Subjects
Neurology, 610 Medicine & health, Neurology (clinical)
Abstract

Background and aimIdentification of paraneoplastic hypercoagulability in stroke patients helps to guide investigations and prevent stroke recurrence. A previous study demonstrated an association between the absence of the susceptibility vessel sign (SVS) on brain MRI and active cancer in patients treated with mechanical thrombectomy. The present study aimed to confirm this finding and assess an association between the absence of the hyperdense vessel sign (HVS) on head CT and active cancer in all stroke patients.MethodsSVS and HVS status on baseline imaging were retrospectively assessed in all consecutive stroke patients treated at a comprehensive stroke center between 2015 and 2020. Active cancer, known at the time of stroke or diagnosed within 1 year after stroke (occult cancer), was identified. Adjusted odds ratios (aOR) and their 95% confidence interval (CI) for the association between the thrombus imaging characteristics and cancer were calculated using multivariable logistic regression.ResultsOf the 2,256 patients with thrombus imaging characteristics available at baseline, 161 had an active cancer (7.1%), of which 36 were occult at the time of index stroke (1.6% of the total). The absence of SVS was associated with active cancer (aOR 3.14, 95% CI 1.45–6.80). No significance was reached for the subgroup of occult cancer (aOR 3.20, 95% CI 0.73–13.94). No association was found between the absence of HVS and active cancer (aOR 1.07, 95% CI 0.54–2.11).ConclusionThe absence of SVS but not HVS could help to identify paraneoplastic hypercoagulability in stroke patients with active cancer and guide patient care.

Published
2023
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34. sj-docx-1-eso-10.1177_23969873231164274 – Supplemental material for Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy

Author

Mujanovic, Adnan, Brigger, Robin, Kurmann, Christoph C, Ng, Felix, Branca, Mattia, Dobrocky, Tomas, Meinel, Thomas R, Windecker, Daniel, Almiri, William, Grunder, Lorenz, Beyeler, Morin, Seiffge, David J, Pilgram-Pastor, Sara, Arnold, Marcel, Piechowiak, Eike I, Campbell, Bruce, Gralla, Jan, Fischer, Urs, and Kaesmacher, Johannes

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-eso-10.1177_23969873231164274 for Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy by Adnan Mujanovic, Robin Brigger, Christoph C Kurmann, Felix Ng, Mattia Branca, Tomas Dobrocky, Thomas R Meinel, Daniel Windecker, William Almiri, Lorenz Grunder, Morin Beyeler, David J Seiffge, Sara Pilgram-Pastor, Marcel Arnold, Eike I Piechowiak, Bruce Campbell, Jan Gralla, Urs Fischer and Johannes Kaesmacher in European Stroke Journal

Published
2023
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35. Impact of sex in stroke in the young

Author

Schwarzwald, Anina, Fischer, Urs, Seiffge, David, Beyeler, Morin, Scutelnic, Adrian, Kaesmacher, Johannes, Mordasini, Pasquale, Dobrocky, Tomas, Gralla, Jan, Heldner, Mirjam R, Umarova, Roza, Meinel, Thomas R, Arnold, Marcel, Jung, Simon, and Goeggel Simonetti, Barbara

Subjects
Multidisciplinary, 610 Medicine & health
Abstract

Background and purpose Limited data is available on sex differences in young stroke patients describing discrepant findings. This study aims to investigate the sex differences in young stroke patients. Methods Prospective cohort study comparing risk factors, etiology, stroke localization, severity on admission, management and outcome in patients aged 16–55 years with acute ischemic stroke consecutively included in the Bernese stroke database between 01/2015 to 12/2018 with subgroup analyses for very young (16-35y) and young patients (36-55y). Results 689 patients (39% female) were included. Stroke in women dominated in the very young (53.8%, p Conclusions The main finding of this study is that sex specific risk factors in women may contribute to a large extent to the higher incidence of stroke in the very young in women. Important modifiable stroke risk factors, such as arterial hypertension, diabetes mellitus and atrial fibrillation did not differ in women and men, either in the young as well as in the very young. These findings have major implications for primary preventive strategies of stroke in young people.

Published
2023
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36. Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular events

Author

Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Vanguru, Husitha Reddy, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Lesaine, Emilie, Nolte, Christian H., Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, Jose Dominguo, Tsivgoulis, Georgios, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P.N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Loochtan, Aaron I., Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Demeestere, Jelle, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Uchino, Ken, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Inoa, Violiza, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Goyal, Nitin, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Charidimou, Andreas, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Siegler, James E., Coutinho, Jonathan M., Rinkel, Leon A., Dippel, Diederik W.J., van Dam-Nolen, Dianne H.K., Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Yaghi, Shadi, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, de Sousa, Diana Aguiar, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Mohammaden, Mahmoud H., Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Haussen, Diogo C., Fonseca, Luisa, Marto, João Pedro, Melo, Teresa Pinho e, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Kristoffersen, Espen Saxhaug, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Perez-Sanchez, Soledad, García Sánchez, María Jesús, Lereis, Virginia Pujol, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T.P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Scollo, Sergio Daniel, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Özcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, Campbell, Bruce C. V., John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Ma, Alice, Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Thomas, James Orton, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Parsons, Mark W., Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Singhal, Shaloo, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Slater, Lee-Anne, Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutierrez, Santiago, Tomazini Martins, Rodrigo, Puri, Ajit S., Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, Jose Rafael, Rost, Natalia S., Rothstein, Aaron, Enzinger, Chris, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Gattringer, Thomas, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., Rahman, Aminur, Nogueira, Raul G., Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C.T., de Oliveira Neves, Luciana, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Lameirinhas da Silva, Isabelle, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Angel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, and Repositório da Universidade de Lisboa

Abstract

© 2022 American Academy of Neurology, Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020). Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results: There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations. Discussion: There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.

Published
2023

37. sj-pdf-2-eso-10.1177_23969873231164274 – Supplemental material for Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy

Author

Mujanovic, Adnan, Brigger, Robin, Kurmann, Christoph C, Ng, Felix, Branca, Mattia, Dobrocky, Tomas, Meinel, Thomas R, Windecker, Daniel, Almiri, William, Grunder, Lorenz, Beyeler, Morin, Seiffge, David J, Pilgram-Pastor, Sara, Arnold, Marcel, Piechowiak, Eike I, Campbell, Bruce, Gralla, Jan, Fischer, Urs, and Kaesmacher, Johannes

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-2-eso-10.1177_23969873231164274 for Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy by Adnan Mujanovic, Robin Brigger, Christoph C Kurmann, Felix Ng, Mattia Branca, Tomas Dobrocky, Thomas R Meinel, Daniel Windecker, William Almiri, Lorenz Grunder, Morin Beyeler, David J Seiffge, Sara Pilgram-Pastor, Marcel Arnold, Eike I Piechowiak, Bruce Campbell, Jan Gralla, Urs Fischer and Johannes Kaesmacher in European Stroke Journal

Published
2023
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38. Impact of sex in stroke in the young

Author

Schwarzwald, Anina, primary, Fischer, Urs, additional, Seiffge, David, additional, Beyeler, Morin, additional, Scutelnic, Adrian, additional, Kaesmacher, Johannes, additional, Mordasini, Pasquale, additional, Dobrocky, Tomas, additional, Gralla, Jan, additional, Heldner, Mirjam R., additional, Umarova, Roza, additional, Meinel, Thomas R., additional, Arnold, Marcel, additional, Jung, Simon, additional, and Goeggel Simonetti, Barbara, additional

Published
2023
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39. Prediction of delayed reperfusion in patients with incomplete reperfusion following thrombectomy

Author

Mujanovic, Adnan, primary, Brigger, Robin, additional, Kurmann, Christoph C, additional, Ng, Felix, additional, Branca, Mattia, additional, Dobrocky, Tomas, additional, Meinel, Thomas R, additional, Windecker, Daniel, additional, Almiri, William, additional, Grunder, Lorenz, additional, Beyeler, Morin, additional, Seiffge, David J, additional, Pilgram-Pastor, Sara, additional, Arnold, Marcel, additional, Piechowiak, Eike I, additional, Campbell, Bruce, additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2023
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40. Abstract Number ‐ 184: Prediction Model For Medical Rescue Treatment Strategies In Patients With Incomplete Reperfusion

Author

Mujanovic, Adnan, primary, Kurmann, Christoph, additional, Dobrocky, Tomas, additional, Meinel, Thomas, additional, Grunder, Lorenz, additional, Beyeler, Morin, additional, Lang, Matthias F, additional, Jung, Simon, additional, Klail, Tomas, additional, Hoffmann, Angelika, additional, Seiffge, David J, additional, Heldner, Mirjam, additional, Pilgram‐Pastor, Sara, additional, Mordasini, Pasquale, additional, Arnold, Marcel, additional, Piechowiak, Eike I, additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2023
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41. Abstract TMP3: Prediction Model For Medical Rescue Treatment Strategies In Patients With Incomplete Reperfusion

Author

Mujanovic, Adnan, primary, Kurmann, Christoph, additional, Dobrocky, Tomas, additional, Meinel, Thomas, additional, Almiri, William, additional, Grunder, Lorenz, additional, Beyeler, Morin, additional, Lang, Matthias, additional, Jung, Simon, additional, Klail, Tomas, additional, Hoffmann, Angelika, additional, Seiffge, David, additional, Heldner, Mirjam, additional, Pilgram-Pastor, Sara, additional, Mordasini, Pasquale, additional, Arnold, Marcel, additional, Piechowiak, Eike, additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2023
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44. Small vessel disease burden and risk of recurrent cerebrovascular events in patients with lacunar stroke and intracerebral haemorrhage attributable to deep perforator arteriolopathy.

Author

Goeldlin, Martina B, Vynckier, Jan, Mueller, Madlaine, Drop, Boudewijn, Maamari, Basel, Vonlanthen, Noah, Siepen, Bernhard M, Hakim, Arsany, Kaesmacher, Johannes, Jesse, Christopher Marvin, Mueller, Mandy D, Meinel, Thomas R, Beyeler, Morin, Clénin, Leander, Gralla, Jan, Z'Graggen, Werner, Bervini, David, Arnold, Marcel, Fischer, Urs, and Seiffge, David J

Published
2023
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45. Association of Chronic Covert Cerebral Infarctions and White Matter Hyperintensities With Atrial Fibrillation Detection on Post‐Stroke Cardiac Rhythm Monitoring: A Cohort Study

Author

Amberger, Ulfrid, primary, Lippert, Julian, additional, Mujanovic, Adnan, additional, Beyeler, Morin, additional, Siepen, Bernhard, additional, Vynckier, Jan, additional, Scutelnic, Adrian, additional, Goeldlin, Martina, additional, Seiffge, David, additional, Jung, Simon, additional, Gralla, Jan, additional, Arnold, Marcel, additional, Kaesmacher, Johannes, additional, Reichlin, Tobias, additional, Tanner, Hildegard, additional, Fischer, Urs, additional, Roten, Laurent, additional, and Meinel, Thomas Raphael, additional

Published
2022
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46. Importance of Delayed Reperfusions in Patients With Incomplete Thrombectomy

Author

Mujanovic, Adnan, primary, Jungi, Noel, additional, Kurmann, Christoph C., additional, Dobrocky, Tomas, additional, Meinel, Thomas R., additional, Almiri, William, additional, Grunder, Lorenz, additional, Beyeler, Morin, additional, Lang, Matthias F., additional, Jung, Simon, additional, Klail, Tomas, additional, Hoffmann, Angelika, additional, Seiffge, David J., additional, Heldner, Mirjam R., additional, Pilgram-Pastor, Sara, additional, Mordasini, Pasquale, additional, Arnold, Marcel, additional, Piechowiak, Eike I., additional, Gralla, Jan, additional, Fischer, Urs, additional, and Kaesmacher, Johannes, additional

Published
2022
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47. Bridging intravenous thrombolysis in patients with atrial fibrillation

Author

Mujanovic, Adnan, Kurmann, Christoph C, Dobrocky, Tomas, Olivé-Gadea, Marta, Maegerlein, Christian, Pierot, Laurent, Mendes Pereira, Vitor, Costalat, Vincent, Psychogios, Marios, Michel, Patrik, Beyeler, Morin, Piechowiak, Eike I, Seiffge, David J, Mordasini, Pasquale, Arnold, Marcel, Gralla, Jan, Fischer, Urs, Kaesmacher, Johannes, and Meinel, Thomas R

Subjects
Neurology, 610 Medicine & health, Neurology (clinical)
Abstract

Background and purpose 40% of acute ischemic stroke patients treated by mechanical thrombectomy (MT) have a clinical history of atrial fibrillation (AF). The safety of bridging intravenous thrombolysis (IVT) (MT + IVT) is currently being discussed. We aimed to analyze the interaction between oral anticoagulation (OAC) status or AF with bridging IVT, regarding the occurrence of symptomatic intracranial hemorrhage (sICH) and functional outcome. Materials and Methods Multicentric observational cohort study (BEYOND-SWIFT registry) of consecutive patients undergoing MT between 2010 and 2018 (n = 2,941). Multinomial regression models were adjusted for prespecified baseline and plausible pathophysiological covariates identified on a univariate analysis to assess the association of AF and OAC status with sICH and good outcomes (90-day modified Rankin Scale score 0-2). Results In the total cohort (median age 74, 50.6% women), 1,347 (45.8%) patients had AF. Higher admission National Institutes of Health Stroke Scale (NIHSS) score (aOR 1.04 [95% 1.02-1.06], per point of increase) and prior medication with Vitamin K antagonists (VKA) (aOR 2.19 [95% 1.27-3.66]) were associated with sICH. Neither AF itself (aOR 0.71 [95% 0.41-1.24]) nor bridging IVT (aOR 1.08 [0.67-1.75]) were significantly associated with increased sICH. Receiving bridging IVT (aOR 1.61 [95% 1.24-2.11]) was associated with good 90-day outcome, with no interaction between AF and IVT (p = 0.92). Conclusion Bridging IVT appears to be a reasonable clinical option in selected patients with AF. Given the increased sICH risk in patients with VKA, subgroup analysis of the randomized controlled trials should analyze whether patients with VKA might benefit from withholding bridging IVT. Registration clinicaltrials.gov; Unique identifier: NCT03496064.

Published
2022
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48. Migraine aura-like symptoms at onset of stroke and stroke-like symptoms in migraine with aura

Author

Scutelnic, Adrian, primary, Kreis, Lukas A., additional, Beyeler, Morin, additional, Heldner, Mirjam R., additional, Meinel, Thomas R., additional, Kaesmacher, Johannes, additional, Hakim, Arsany, additional, Arnold, Marcel, additional, Fischer, Urs, additional, Mattle, Heinrich P., additional, Schankin, Christoph J., additional, and Jung, Simon, additional

Published
2022
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49. Impact of sex in stroke in the young

Author

Schwarzwald, Anina, primary, Fischer, Urs, additional, Seiffge, David, additional, Beyeler, Morin, additional, Scutelnic, Adrian, additional, Kaesmacher, Johannes, additional, Mordasini, Pasquale, additional, Dobrocky, Tomas, additional, Gralla, Jan, additional, Heldner, Mirjam R, additional, Umarova, Roza, additional, Meinel, Thomas R, additional, Arnold, Marcel, additional, Jung, Simon, additional, and Simonetti, Barbara Goeggel, additional

Published
2022
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