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18 results on '"Beyene, Robel T."'

4. Provider Perceptions of Antibiotic Initiation Strategies for Hospital-Acquired Pneumonia

Author

Swilling, Aubrey C., primary, O'Dell, Jacob C., additional, Beyene, Robel T., additional, Watson, Christopher M., additional, Sawyer, Robert G., additional, Chollet-Hinton, Lynn, additional, Simpson, Steven Q., additional, Atchison, Leanne, additional, Derickson, Michael, additional, Cooper, Lindsey C., additional, Pennington, G.Patton, additional, VandenBerg, Sheri, additional, Halimeh, Bachar N., additional, Hughes, Dorothy, additional, and Guidry, Christopher A., additional

Published
2024
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5. 2581. Desirability of Outcome Ranking and Response Adjusted for Antibiotic Risk (DOOR/RADAR) Post-Hoc Analysis Supports Equipoise for Antibiotic Initiation Strategies in ICU-Acquired Pneumonia

Author

Guidry, Christopher A, primary, Chollet-Hinton, Lynn, additional, Baker, Jordan, additional, O’Dell, Jacob C, additional, Beyene, Robel T, additional, Watson, Christopher M, additional, Sawyer, Robert G, additional, Simpson, Steven Q, additional, Atchison, Leanne, additional, Derickson, Michael, additional, Cooper, Lindsey C, additional, Pennington, G Patton, additional, VandenBerg, Sheri, additional, and Halimeh, Bachar N, additional

Published
2023
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7. Desirability of Outcome Ranking and Response Adjusted for Antibiotic Risk (DOOR/RADAR) Post Hoc Analysis Supports Equipoise for Antibiotic Initiation Strategies in Intensive Care Unit-Acquired Pneumonia.

Author

Guidry, Christopher A., Chollet-Hinton, Lynn, Baker, Jordan, O'Dell, Jacob C., Beyene, Robel T., Watson, Christopher M., Sawyer, Robert G., Simpson, Steven Q., Atchison, Leanne, Derickson, Michael, Cooper, Lindsey C., Pennington II, G. Patton, VandenBerg, Sheri, and Halimeh, Bachar N.

Published
2024
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9. The Effect of Propofol on Peri-Induction Hemodynamics and Resuscitation in Operative Penetrating Trauma

Author

Levin, Jeremy H., Wallace, Marshall W., Hess, T. Noel, Beavers, Jennifer R., Chang, Tony, and Beyene, Robel T.

Abstract

Background Hemorrhaging trauma patients may be disproportionately affected by choice of induction agent during rapid sequence intubation (RSI). Etomidate, ketamine, and propofol are safe in the trauma population-at-large but have not been assessed in patients with ongoing hemorrhage. We hypothesize that in hemorrhaging patients with penetrating injury, propofol deleteriously affects peri-induction hypotension compared to etomidate and ketamine.Methods Retrospective cohort study. Primary outcome was the effect of induction agent on peri-induction systolic blood pressure. Secondary outcomes were the incidence of peri-induction vasopressor use and quantity of peri-induction blood transfusion requirements. Linear multivariate regression modeling assessed the effect of induction agent on the variables of interest.Results 169 patients were included, 146 received propofol and 23 received etomidate or ketamine. Univariate analysis revealed no difference in peri-induction systolic blood pressure (P = .53), peri-induction vasopressor administration (P = .62), or transfusion requirements within the first hour after induction (PRBC P = .24, FFP P = .19, PLT P = .29). Choice of RSI agent did not independently predict peri-induction systolic blood pressure or blood product administration. Rather, only presenting shock index independently predicted peri-induction hypotension.Conclusions This is the first study to directly assess the peri-induction effects of anesthetic induction agent choice in penetrating trauma patients undergoing emergent hemorrhage control surgery. Propofol does not appear to worsen peri-induction hypotension regardless of dose. Patient physiology is most predictive of peri-induction hypotension.

Published
2024
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13. Components of Existing National Surgical Site Infection Surveillance Programs Based on a Case Series of Low- and Middle-Income Countries: Building Blocks for Success and Opportunities for Improvement

Author

Forrester, Joseph D., primary, Bekele, Abebe, additional, Stefan, Andrei-Marius, additional, Tshokey, Tshokey, additional, Berndtson, Allison E., additional, Beyene, Robel T., additional, Chou, Jesse, additional, Sawyer, Robert G., additional, Valenzuela, Julie Y., additional, and Rickard, Jennifer, additional

Published
2023
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14. Trial of antibiotic restraint in presumed pneumonia: A Surgical Infection Society multicenter pilot

Author

Guidry, Christopher A., primary, Beyene, Robel T., additional, Watson, Christopher M., additional, Sawyer, Robert G., additional, Chollet-Hinton, Lynn, additional, Simpson, Steven Q., additional, Atchison, Leanne, additional, Derickson, Michael, additional, Cooper, Lindsey C., additional, Pennington, G. Patton, additional, VandenBerg, Sheri, additional, Halimeh, Bachar N., additional, and O'Dell, Jacob C., additional

Published
2022
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16. Acute pain consult and management is associated with improved mortality in rib fracture patients

Author

Sborov, Katherine D, primary, Dennis, Bradley M, additional, de Oliveira Filho, Getúlio Rodrigues, additional, Bellister, Seth A, additional, Statzer, Nicholas, additional, Stonko, David P, additional, Guyer, Richard A, additional, Wanderer, Jonathan P, additional, Beyene, Robel T, additional, McEvoy, Matthew D, additional, and Allen, Brian Frazer Scott, additional

Published
2022
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18. EGFR signaling is differentially activated in patient-derived glioblastoma stem cells.

Author

Howard, Brian M., Gursel, Demirkan B., Bleau, Anne-Marie, Beyene, Robel T., Holland, Eric C., and Boockvar, John A.

Subjects
BRAIN tumors, STEM cells, GLIOBLASTOMA multiforme, TUMORS, EPIDERMAL growth factor
Abstract

Evidence suggests that stem-like cells are responsible for initiation, maintenance and recurrence of solid tumors, including Glioblastoma Multiforme (GBM). GBM is an intractable, highly lethal tumor of the central nervous system. Although epidermal growth factor receptor (EGFR) is highly expressed in many GBMs, anti-EGFR therapies have been unsuccessful as treatment. Few studies have examined EGFR activation in GBM stem cells (GSCs) to determine if patient-specific GSCs are amenable to anti-EGFR therapy pre-clinically. We hypothesized that EGFR activation in GSCs varied between patients and was an important determinant of responsiveness to anti-EGFR therapy. Cell cycle and apoptosis analysis was performed on tumor-spheres by immuncytochemistry in the presence and absence of the AG1478. Second messenger pathways operative in these processes were elucidated by immuno-blotting. EGFR activated AKT and inactivated GSK3β in EGFR+/PTEN+ GSCs. AG1478 and erlotinib significantly decreased the total number of tumor-spheres that EGFR+/PTEN+ GSCs generated and the rate of sphere formation. Inhibition of EGFR signaling by AG1478 increased GSC senescence and apoptosis, likely via inhibition of AKT and activation of GSK3β. Sphere formation by EGFR-/PTEN- GSCs was independent of EGF stimulation, but dependant on B27 growth supplement. Our data suggest that EGFR+/PTEN+ GSCs are susceptible to anti-EGFR therapy in vitro. [ABSTRACT FROM AUTHOR]

Published
2010

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