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17 results on '"Bezerra da Cunha, Francisco Assis"'

1. Evaluation of the antibacterial and inhibitory activity of the MepA efflux pump of Staphylococcus aureus by riparins I, II, III, and IV

Author

Rodrigues dos Santos Barbosa, Cristina, Macêdo, Nair Silva, de Sousa Silveira, Zildene, Rocha, Janaína Esmeraldo, Freitas, Thiago Sampaio, Muniz, Débora Feitosa, Araújo, Isaac Moura, Datiane de Morais Oliveira-Tintino, Cícera, Marinho, Emmanuel Silva, Nunes da Rocha, Matheus, Marinho, Marcia Machado, Bezerra, Antonio Henrique, Ribeiro de Sousa, Gabriela, Barbosa-Filho, José Maria, de Souza-Ferrari, Jailton, Melo Coutinho, Henrique Douglas, Silva dos Santos, Hélcio, and Bezerra da Cunha, Francisco Assis

Published
2023
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2. Evaluation of antibacterial and toxicological activities of essential oil of Ocimum gratissimum L. and its major constituent eugenol

Author

Silva, Julio Cesar, Silva Pereira, Raimundo Luiz, Sampaio de Freitas, Thiago, Rocha, Janaína Esmeraldo, Macedo, Nair Silva, de Fatima Alves Nonato, Carla, Linhares, Marina Leite, Arruda Tavares, Daniely Sampaio, Bezerra da Cunha, Francisco Assis, Melo Coutinho, Henrique Douglas, Gonçalo de Lima, Sidney, Pereira-Junior, Francisco Nascimento, Araújo Maia, Francisco Paulo, Pita Neto, Ivo Cavalcante, Galvão Rodrigues, Fabiola Fernandes, and Garcia Santos, George Joaquim

Published
2022
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6. Chemical Profile and Biological Potential of Scaptotrigona Bee Products (Hymenoptera, Apidae, Meliponini): An review

Author

Silveira, Zildene de Sousa, primary, Silva Macêdo, Nair Silva Macêdo, additional, de Menezes Dantas, Débora, additional, Vieira Brito, Samuel, additional, Silva dos Santos, Helcio Silva, additional, de Sousa Gomese, Renata Valéria Regis, additional, Melo Coutinho, Henrique Douglas Assis, additional, Bezerra da Cunha, Francisco Assis Assis, additional, and da Silva, Márcia Vanusa Vanusa, additional

Published
2024
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7. Chemical characterization and biological activities of Jandaíra stingless bee products (Melipona subnitida, Ducke, 1911): a brief review

Author

Menezes Dantas, Débora, primary, dos Santos Barbosa, Cristina Rodrigues, additional, Macêdo, Nair Silva, additional, de Sousa Silveira, Zildene, additional, Bezerra, Suieny Rodrigues, additional, Bezerra, Antonio Henrique, additional, Lira da Silva, José Bruno, additional, Martins da Costa, José Galberto, additional, Silva, Tania Maria Sarmento, additional, Coutinho, Henrique Douglas Melo, additional, and Bezerra da Cunha, Francisco Assis, additional

Published
2023
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10. Antibacterial and Toxic Activity of Geopropolis Extracts from Melipona subnitida (Ducke, 1910) (Hymenoptera: Apidae) and Scaptotrigona depilis (Moure, 1942) (Hymenoptera: Apidae).

Author

Costa dos Santos, Danilo, Silva Macêdo, Nair, de Sousa Silveira, Zildene, Silva Pereira, Raimundo Luiz, Moura Araújo, Isaac, Justino Araújo, Ana Carolina, Alves Gonçalves, Sheila, da Silveira Regueira Neto, Marcos, de Queiroz Balbino, Valdir, Torres de Carvalho, Airton, Oliveira de Veras, Bruno, Bezerra da Cunha, Francisco Assis, Melo Coutinho, Henrique Douglas, and Vieira Brito, Samuel

Published
2023
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11. AVALIAÇÃO DA ATIVIDADE ANTIFÚNGICA DO EXTRATO AQUOSO DAS FOLHAS DE Libidibia ferrea (MART. EX TUL.) L. P. QUEIROZ (PAU FERRO)

Author

Pereira Da Silva Júnior, João, primary, Ferreira de Lima, Luciene, additional, Lucas dos Santos, Antonia Thassya, additional, Targino Machado, Antonio Júdson, additional, Pereira da Cruz, Rafael, additional, Sampaio Freitas, Thiago, additional, Bezerra da Cunha, Francisco Assis, additional, Melo Coutinho, Henrique Douglas, additional, and Morais-Braga, Maria Flaviana Bezerra, additional

Published
2021
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12. Phytochemical prospection of Azadirachta indica stem bark ethanolic extract and evaluation of its toxicity against Drosophila melanogaster

Author

Marques Cordeiro, Paula Patricia, primary, de Sousa Júnior, Dárcio Luiz, primary, Sampaio dos Santos, Joycy Francely, primary, da Silva, Larissa, primary, de Lacerda Neto, Luiz Jardelino, primary, Costa dos Santos, Maria Apoliana, primary, Bezerra da Cunha, Francisco Assis, primary, and Melo Coutinho, Henrique Douglas, primary

Published
2018
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13. Safety assessment and antioxidant activity of Lantana montevidensis leaves: contribution to its phytochemical and pharmacological activity

Author

Barros, Luiz Marivando, Duarte, Antonia Eliene, Waczuk, Emily Pansera, Roversi, Katiane, Bezerra da Cunha, Francisco Assis, Rolon, Mirian, Coronel, Cathia, Vega Gomez, Maria Celeste, Alencar de Menezes, Irwin Rose, Martins da Costa, Jose Galberto, Boligon, Aline Augusti, Hassan, Waseem, Souza, Diogo Onofre, Teixeira da Rocha, Joao Batista, and Kamdem, Jean Paul

Subjects
010404 medicinal & biomolecular chemistry, 03 medical and health sciences, 0302 clinical medicine, Lantana montevidensis, genotoxicity, cytotoxicity, Original Article, osmotic fragility, HPLC-DAD, 01 natural sciences, 030217 neurology & neurosurgery, 0104 chemical sciences
Abstract

Lantana camara, the widely studied species, and L. montevidensis, the less studied species of the genus Lantana are both used in traditional medicine for the same purpose (anti-asthma, anti-ulcer, anti-tumor, etc). However, little is known about the toxicity of L. montevidensis and there is limited information on its chemical constituents. Here, we investigated for the first time the genotoxicity and cytotoxicity of the ethanolic (EtOH) and aqueous extracts from the leaves of Lantana montevidensis in human leukocytes, as well as their possible interaction with human erythrocyte membranes in vitro. The antioxidant activities of both extracts were also investigated in chemical and biological models. Treatment of leukocytes with EtOH or aqueous extracts (1-480 µg/mL) did not affect DNA damage index, but promoted cytotoxicity at higher concentrations (240-480 µg/mL). Both extracts did not modify the osmotic fragility of human erythrocytes. The extracts scavenged DPPH radical and prevented Fe2+-induced lipid peroxidation in rat's brain and liver homogenates, and this was likely not attributed to Fe (II) chelation. The HPLC analysis of the extracts showed different amounts of polyphenolic compounds (isoquercitrin, gallic acid, catechin, ellagic acid, apigenin, kaempferol, caffeic acid, rutin, quercitrin, quercetin, chlorogenic acid, luteolin) that may have contributed to these effects. These results supported information on the functional use of L. montevidensis in folk medicine., EXCLI Journal; 16:Doc566; ISSN 1611-2156

Published
2017
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14. Polyphenolic Composition And Evaluation Of Antioxidant Activity, Osmotic Fragility And Cytotoxic Effects Of Raphiodon Echinus (Nees & Mart.) Schauer

Author

Duarte, Antonia Eliene, Waczuk, Emily Pansera, Roversi, Katiane, Pessoa da Silva, Maria Arlene, Barros, Luiz Marivando, Bezerra da Cunha, Francisco Assis, de Menezes, Irwin Rose Alencar, Martins da Costa, Jose Galberto, Boligon, Aline Augusti, Ademiluyi, Adedayo Oluwaseun, Kamdem, Jean Paul, Teixeira Rocha, Joao Batista, and Burger, Marilise Escobar

Abstract

Raphiodon echinus (R. echinus) is used in Brazilian folk medicine for the treatment of inflammation, coughs, and infectious diseases. However, no information is available on the potential antioxidant, cytotoxicity and genotoxicity of this plant. In this study, the polyphenolic constituents, antioxidant capacity and potential toxic effects of aqueous and ethanolic extracts of R. echinus on human erythrocytes and leukocytes were investigated for the first time. R. echinus extracts showed the presence of Gallic, chlorogenic, caffeic and ellagic acids, rutin, quercitrin and quercetin. Aqueous and ethanolic extracts of R. echinus exhibited antioxidant activity in DPPH radical scavenging with IC50 = 111.9 g/mL (EtOH extract) and IC50 = 227.9 g/mL (aqueous extract). The extracts inhibited Fe2+ (10 M) induced thiobarbituric acid reactive substances (TBARS) formation in rat brain and liver homogenates. The extracts (30-480 g/mL) did not induce genotoxicity, cytotoxicity or osmotic fragility in human blood cells. The findings of this present study therefore suggest that the therapeutic effect of R. echinus may be, in part, related to its antioxidant potential. Nevertheless, further in vitro and in vivo studies are required to ascertain the safety margin of its use in folk medicine.

Published
2016

15. Evaluation of antibacterial and toxicological activities of essential oil of Ocimum gratissimumL. and its major constituent eugenol

Author

Silva, Julio Cesar, Silva Pereira, Raimundo Luiz, Sampaio de Freitas, Thiago, Rocha, Janaína Esmeraldo, Macedo, Nair Silva, de Fatima Alves Nonato, Carla, Linhares, Marina Leite, Arruda Tavares, Daniely Sampaio, Bezerra da Cunha, Francisco Assis, Melo Coutinho, Henrique Douglas, Gonçalo de Lima, Sidney, Pereira-Junior, Francisco Nascimento, Araújo Maia, Francisco Paulo, Pita Neto, Ivo Cavalcante, Galvão Rodrigues, Fabiola Fernandes, and Garcia Santos, George Joaquim

Abstract

The present study aimed to comparatively analyze the antibacterial activity, combined with antibiotics, and toxicological activity of the essential oil of O. gratissimumL. and its major compound, eugenol. The phytochemical analysis of the essential oil was performed by gas chromatography coupled with mass spectrometry. The minimum inhibitory concentration and combined antibiotic activity were performed by microdilution. Drosophila melanogasterwas the model organism chosen to evaluate the toxicological response of substances. The chromatographic assay showed eugenol as the major compound of the essential oil of O. gratissimumL. The microbiological assays showed that in terms of antibacterial activity, both products showed similar activity, quite significant in Gram-negatives, such as those of strains of Pseudomonas aeruginosa. Similar results were verified in the modulatory activity, allowing the verification that the bioactivity performed by the essential oil of O. gratissimumL. is mainly influenced by its major constituent. Although the EC50 of the compounds varied subtly, the essential oil was less toxic compared to eugenol. The information obtained in the present study demonstrates that the essential oil of O. gratissimumL. is a promising antibacterial agent and better tolerated than its majority compound alone, in the model organism D. melanogaster.

Published
2022
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17. Atividade moduladora de extratos etanólico e hexânico de raiz de Costus cf. arabicus sobre drogas antimicrobianas.

Author

Relison Tintino, Saulo, Bezerra da Cunha, Francisco Assis, Alves dos Santos, Karla Katiúcia, de Melo Guedes, Glaucia Morgana, Sobral Souza, Celestina Elba, Ferreira Matias, Edinardo Fagner, Bezerra Morais-Braga, Maria Flaviana, Cosme Andrade, Jacqueline, Martins da Costa, José Galberto, Audilene de Freitas, Maria, and Melo Coutinho, Henrique Douglas

Subjects
ESCHERICHIA coli, ENTEROTOXINS, ANTI-infective agents, MEDICINAL plants, AMINOGLYCOSIDES, ANTIFUNGAL agents
Abstract

Copyright of Revista Brasileira de Biociencias is the property of Revista Brasileira de Biociencias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2013

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