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1. Updated evaluation of potential ultra-low Q value $\beta$-decay candidates

Author

Keblbeck, Dakota K., Bhandari, Ramesh, Gamage, Nadeesha D., Gamage, Madhawa Horana, and Redshaw, Matthew

Subjects
Nuclear Experiment
Abstract

"Ultra-low" Q value $\beta$ decays are referred to as such due to their low decay energies of less than $\sim$1 keV. Such a low energy decay is possible when the parent nucleus decays into an excited state in the daughter, with an energy close to that of the Q value. These decays are of interest as potential new candidates for neutrino mass determination experiments and as a testing ground for studies of atomic interference effects in the nuclear decay process. In this paper, we provide an updated evaluation of atomic mass data and nuclear energy level data to identify potential ultra-low Q value $\beta$ decay candidates. For many of these candidates, more precise and accurate atomic mass data is needed to determine if the Q value of the potential ultra-low decay branch is energetically allowed and in fact ultra-low. The precise atomic mass measurements can be achieved via Penning trap mass spectrometry.

Published
2022
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3. Polarization-Induced Interaction as a Perturbation within Orbital Angular Momentum(OAM) Modes of an Optical Fiber

Author

Bhandari, Ramesh

Subjects
Physics - Optics
Abstract

We investigate the role of polarization effects in orbital angular momentum modes of an optical fiber. Specifically, we revisit the removal of the degeneracy of the $HE$ and the $EH$ vector modes that exists within the weakly guiding approximation (WGA); within WGA, these two vector modes coalesce into a single spatial (scalar) orbital angular momentum (OAM) mode, defined by a common topological charge and associated with left or right circular polarization. While the polarization term of the vector wave equation acting as a Hermitian perturbation operator accounts for the splitting of the $HE$ and the $EH$ vector modes, its extension to explain the accompanying field correction, called the polarization-induced field, encounters hurdles; this field is characterized by a topological charge differing by two in magnitude. The problems are critically examined with a possible remedy and its implications., Comment: 6 pages

Published
2021

6. Nature of the orbital angular momentum (OAM) fields in a multilayered fiber

Author

Bhandari, Ramesh

Subjects
Physics - Optics
Abstract

We provide a theoretical analysis of the nature of the orbital angular momentum (OAM) modal fields in a multilayered fiber, such as the step-index fiber and the ring-core fiber. In a detailed study of the vector field solutions of the step-index fiber (in the exponential basis), we discover that the polarization-induced field component is a modified scalar OAM field (as opposed to a standard OAM scalar field) with a shifted intensity pattern in the weakly guiding approximation (WGA); the familiar intensity donut pattern is reduced or increased in radius depending upon whether it is a case of spin-alignment or anti-alignment with the OAM. Such a shift in the intensity pattern appears to be a general feature of the field of a multilayered fiber as seen from an extension to the ring-core fiber. Additionally, we derive a general expression for the polarization-correction to the scalar propagation constant, which includes, for the first time, the contribution of the polarization-induced field. All the analytic expressions are illustrated and validated numerically with application to a step-index fiber, whose analytic solutions are well-known., Comment: 17 pages, 3 figures

Published
2021
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8. Analytic Expressions for Orbital Angular Momentum Modal Crosstalk in a Slightly Elliptical Fiber

Author

Bhandari, Ramesh

Subjects
Physics - Optics
Abstract

Assuming weakly guiding approximation, we examine orbital angular momentum (OAM) mode mixing on account of ellipticity in a fiber and derive a complete set of analytic expressions for spatial crosstalk, using scalar perturbation theory that incorporates fully the existing degeneracy between a spatial OAM mode and its degenerate partner characterized by a topological charge of opposite sign. These expressions, consequently, include an explicit formula for calculating the 2 pi walk-off length over which an input OAM mode converts into its degenerate partner, and back into itself. We further explore the applicability of the derived expressions in the presence of spin-orbit interaction. The expressions constitute a useful mathematical tool in the analysis and design of fibers for spatially-multiplexed mode transmissions. Their utility is demonstrated with application to a few mode and a multimode step-index fiber., Comment: 19 pages, 5 figures; published in IEEE Photonics Journal (see below)

Published
2021
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9. Orbital Angular Momentum (OAM) Mode Mixing in a Bent Step Index Fiber in Perturbation Theory: Multiple Bends

Author

Bhandari, Ramesh

Subjects
Physics - Optics
Abstract

In this paper, we address the impact of multiple fiber bends on orbital angular mode (OAM) mode propagation in a fiber. In particular, we extend the OAM mode-mixing due to a single-fiber bend studied earlier in detail for the step-index fiber, to the case of a succession of bends. The bends may have relative orientation with respect to each other. Analytic expressions leading to crosstalk are given. The OAM mode intensity at the output of a pair of bends is especially studied with emphasis on the intensity pattern changes that arise from the changes in the relative orientation of the bends., Comment: 8 pages, 5 figures; to be submitted for publication in IEEE Photonics Journal

Published
2019
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12. Orbital Angular Momentum (OAM) Mode Mixing in a Bent Step Index Fiber in Perturbation Theory

Author

Bhandari, Ramesh

Subjects
Physics - Optics, Physics - Applied Physics
Abstract

Within the framework of perturbation theory, we explore in detail the mixing of orbital angular momentum(OAM) modes due to a fiber bend in a step-index multimode fiber. Using scalar wave equation, we develop a complete set of analytic expressions for mode-mixing, including those for the $2\pi$ walk-off length, which is the distance traveled within the bent fiber before an OAM mode transforms into its negative topological charge counterpart, and back into itself. The derived results provide insight into the nature of the bend effects, clearly revealing the mathematical dependence on the bend radius and the topological charge. We numerically simulate the theoretical results with applications to a few-mode fiber and a multimode fiber, and calculate bend-induced modal crosstalk with implications for mode-multiplexed systems. The presented perturbation technique is general enough to be applicable to other perturbations like ellipticity and easily extendable to other fibers with step-index-like profile as in the ring fiber., Comment: 20 pages, 5 figures, published in IEEE Photonics Journal

Published
2019
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13. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

Author

Abe, Tomoyuki, Abu Hilal, Moh'd, Achalandabaso Boira, Maria del Mar, Adham, Mustapha, Adam, Mohamed, Ahmad, Maryam, Al-Sarireh, Bilal, Albiol, Maite, Alhaboob, Nassir, Alseidi, Adnan, Ammar, Houssem, Anand, Akshay, Andersson, Bodil, Antonakis, Pantelis, Araya, Veronica, Ashley, Stanley W., Atanasov, Georgi, Ausania, Fabio, Balestri, Ricardo, Banerjee, Abhirup, Banerjee, Sudeep, Banting, Simon, Barauskas, Giedrius, Bartsch, Fabian, Belli, Andrea, Beretta, Simona, Berrevoet, Frederik, Bhandari, Ramesh Singh, Blanco Fernandez, Gerardo, Bolm, Louisa, Bonal, Mathieu, Bozkurt, Emre, Braat, Andries E., Bradshaw, Luke, Bramis, Konstantinos, Branes, Alejandro, Burdine, Lyle, Byrne, Matthew, Caceres, Maria, Castro Santiago, Maria Jesus, Chan, Benjamin, Chong, Lynn, Çoker, Ahmet, Conde Rodriguez, Maria, Croagh, Daniel, Crutchley, Alyn, Cutolo, Carmen, D'Hondt, Mathieu, D'Souza, Daniel, Daams, Freek, Dalla Valle, Raffaele, Davide, José, de Bellis, Mario, de Boer, Marieke, de Meyere, Celine, de Reuver, Philip, Dixon, Matthew, Dorovinis, Panagiotis, Echeverría Bauer, Gabriela, Eduarda, Maria, Eker, Hasan, Erdmann, Joris, Erkan, Mert, Felekouras, Evangelos, Felli, Emanuele, Fernandes, Eduardo, Figueroa Rivera, Eduardo, Fulop, Andras, Galun, Daniel, Gerhards, Michael, Ghorbani, Poya, Giannone, Fabio, Gil, Luis, Giorgakis, Emmanouil, Giuffrida, Mario, Giuliante, Felice, Gkekas, Ioannis, Gomez Bravo, Miguel, Groot Koerkamp, Bas, Guevara, Oscar, Guglielmi, Alfredo, Gulla, Aiste, Gupta, Rahul, Gupta, Amit, Gutiérrez, Marta, Hafeez Bhatti, Abu Bakar, Hagendoorn, Jeroen, Hajee, Zain, Hakeem, Abdul Rahman, Hamid, Hytham, Hassen, Sayed, Heinrich, Stefan, Higuchi, Ryota, Hoffman, Daniel, Holroyd, David, Hughes, Daniel, Ivanecz, Arpad, Iype, Satheesh, Jaen Torrejimeno, Isabel, Joglekar, Shantanu, Jones, Robert, Kaczirek, Klaus, Kanhere, Harsh, Kausar, Ambareen, Kee, Zhanyi, Keilson, Jessica, Kleef, Jorg, Klose, Johannes, Knowles, Brett, Koong, Jun Kit, Kumar, Nagappan, Kunnuru, Supreeth, Lakhey, Paleswan Joshi, Laurenzi, Andrea, Lee, Yeong Sing, Leon, Felipe, Leow, Voon Meng, Lequeu, Jean-Baptiste, Lesurtel, Mickael, Lo, Elisabeth, Löb, Stefan, Lockie, Elizabeth, Lodge, Peter, López Garnica, Dolores, Lopez Lopez, Victor, Lundgren, Linda, Machairas, Nikolaos, Maharjan, Dhiresh, Malde, Deep, Martel, Guillaume, Martin, Julie, Mazzola, Michele, Mehrabi, Arianeb, Memeo, Ricardo, Milana, Flavio, Molina, George, Monette, Leah, Morgul, Haluk, Moris, Dimitrios, Morsi-Yeroyannis, Antonios, Mowbray, Nicholas, Mulita, Francesk, Muttillo, Edoardo Maria, Nandasena, Malith, Nashidengo, Pueya Rashid, Nickkholgh, Arash, Noel, Colin Byron, Ohtsuka, Masayuki, Ozolins, Arturs, Pandanaboyana, Sanjay, Pararas, Nikolaos, Parente, Alessandro, Peng, June, Perfecto Valero, Arkaitz, Perinel, Julie, Perivoliotis, Konstatinos, Perra, Teresa, Pessaux, Patrick, Petruch, Natalie, Piccolo, Gaetano, Piros, Laszlo, Porcu, Alberto, Prabakaran, Viswakumar, Prasad, Raj, Prieto Calvo, Mikel, Primavesi, Florian, Pueyo Periz, Eva Maria, Quaglia, Alberto, Ramia Angel, Jose M., Rammohan, Ashwin, Razionale, Francesco, Robles Campos, Ricardo, Roy, Manas, Rozwadowski, Sophie, Ruffolo, Luis, Ruiz, Natalia, Ruzzenante, Andrea, Saadat, Lily, Said, Mohamed Amine, Saladino, Edoardo, Saliba, Gabriel, Sandstrom, Per, Schena, Carlo Alberto, Scholer, Anthony, Schwarz, Christoph, Serafini, Lorenzo, Serrano, Pablo E., Sharma, Deepak, Sheen, Aali, Siddagangaiah, Vishwanath, Silva, Michael, Singh, Saurabh, Siriwardena, Ajith, Skalski, Michal, Smig, Mante, Soliman, Faris, Sonkar, Abhinav Arun, Sousa Silva, Donzília, Sparrelid, Ernesto, Srinivasan, Parthi, Sternby Eilard, Malin, Strobel, Oliver, Stupan, Urban, Suarez-Munoz, Miguel Angel, Subramaniam, Manisekar, Sugiura, Teiichi, Sutcliffe, Robert, Swank, Hilko, Taylor, Lillian, Thapa, Prabin Bikram, The, Catherine, Thepbunchonchai, Asara, Thieu, Caman, Tiwari, Navneet, Torzilli, Guido, Tovikkai, Chutwichai, Trotovsek, Blaz, Tsaramanidis, Savvas, Tsoulfas, Georgios, Uesaka, Katsuhiko, Umar, Garzali, Urbani, Lucio, Vailas, Michail, van Dam, Ronald, van de Boezem, Peter, van Laarhoven, Stijn, Vanagas, Tomas, Van Dooren, Mike, Viennet, Manon, Vigano, Luca, Vijayashanker, Aarathi, Villodre, Celia, Wakai, Toshifumi, Workneh, Aklile, Xu, Li, Yamamoto, Masakazu, Yang, Zhiying, Young, Robert, Zivanovic, Marko, Balakrishnan, Anita, Barmpounakis, Petros, Demiris, Nikolaos, Jah, Asif, Spiers, Harry V.M., Talukder, Shibojit, Martin, Jack L., Gibbs, Paul, Harper, Simon J.F., Huguet, Emmanuel L., Kosmoliaptsis, Vasilis, Liau, Siong S., Praseedom, Raaj K., Basu, Bristi, de Aretxabala, Xavier, Lendoire, Javier, Maithel, Shishir, Serrablo, Alejandro, and Adsay, Volkan

Published
2023
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18. On the general constraints in single qubit quantum process tomography

Author

Bhandari, Ramesh and Peters, Nicholas A.

Subjects
Quantum Physics
Abstract

We briefly review single-qubit quantum process tomography for trace-preserving and nontrace-preserving processes, and derive explicit forms of the general constraints for fitting experimental data. These new forms provide additional insight into the structure of the process matrix. We illustrate their utility with several examples, including a discussion of qubit leakage error models and the intuition which can be gained from their process matrices., Comment: 7 pages, 1 figure; overlaps and improves upon the first part of our previous submission: arxiv:1502.01016; to appear in Scientific Reports

Published
2016
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21. On single qubit quantum process tomography for trace-preserving and nontrace-preserving maps

Author

Bhandari, Ramesh and Peters, Nicholas A.

Subjects
Quantum Physics
Abstract

We review single-qubit quantum process tomography for trace-preserving and nontrace-preserving processes, and derive explicit forms of the general constraints for fitting experimental data. These forms provide additional insight into the structure of the process matrix as well as reveal a tighter bound on the trace of a nontrace-preserving process than has been previously stated. We also describe, for completeness, how to incorporate measured imperfect input states., Comment: 4 pages, 1 figure

Published
2015

24. Quantum Error Correcting Codes and the Security Proof of the BB84 Protocol

Author

Bhandari, Ramesh

Subjects
Quantum Physics
Abstract

We describe the popular BB84 protocol and critically examine its security proof as presented by Shor and Preskill. The proof requires the use of quantum error correcting codes called the Calderbank-Shor-Steanne (CSS) quantum codes. These quantum codes are constructed in the quantum domain from two suitable classical linear codes, one used to correct for bit-flip errors and the other for phase-flip errors. Consequently, as a prelude to the security proof, the report reviews the essential properties of linear codes, especially the concept of cosets, before building the quantum codes that are utilized in the proof. The proof considers a security entanglement-based protocol, which is subsequently reduced to a "Prepare and Measure" protocol similar in structure to the BB84 protocol, thus establishing the security of the BB84 protocol. The proof, however, is not without assumptions, which are also enumerated. The treatment throughout is pedagogical, and this report, therefore, serves a useful tutorial for researchers, practitioners, and students, new to the field of quantum information science, in particular, quantum cryptography, as it develops the proof in a systematic manner, starting from the properties of linear codes, and then advancing to the quantum error correcting codes, which are critical to the understanding of the security proof., Comment: 89 pages, 1 figure

Published
2014

25. Alternate Forms of the T-Matrix in Quantum State Tomography

Author

Bhandari, Ramesh

Subjects
Quantum Physics
Abstract

In this paper, we focus on alternate forms of the T-matrix used in the Maximum Likelihood Estimate (MLE) procedure for fitting the experimental data collected in quantum state tomography experiments. In particular, we analyze the single quantum state tomography case, deriving in the process three new valid alternate forms for achieving optimality. These alternative forms then serve as a consistency check, thus enhancing the robustness of the MLE fitting process. One form, in particular, serves as a useful compliment to the standard form normally employed. We subsequently provide a generalization of these forms to the case of multiqubit state tomography., Comment: 7 pages; some irrelevant, misleading material in the appendix removed

Published
2014

26. On Single Qubit Quantum State Tomography

Author

Bhandari, Ramesh

Subjects
Quantum Physics
Abstract

In this paper, we derive analytic expressions for the starting (initial) values of the parameters of the T-matrix that is frequently employed in the construction of a theoretical density matrix in a Maximum Likelihood Estimate (MLE) procedure; this optimization procedure is used to fit the experimental data pertaining to single qubit state tomography. Appropriate starting values are critical in achieving a global minimum in the fitting process. We also indicate an analytic way of making the experimentally determined density matrix physical without resorting to the MLE process, if optimality in quantum state tomography can be disregarded, since the ultimate goal is optimality in quantum process tomography., Comment: 9 pages

Published
2014

32. Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study

Author

Balakrishnan, Anita, primary, Barmpounakis, Petros, additional, Demiris, Nikolaos, additional, Jah, Asif, additional, Spiers, Harry V.M., additional, Talukder, Shibojit, additional, Martin, Jack L., additional, Gibbs, Paul, additional, Harper, Simon J.F., additional, Huguet, Emmanuel L., additional, Kosmoliaptsis, Vasilis, additional, Liau, Siong S., additional, Praseedom, Raaj K., additional, Basu, Bristi, additional, de Aretxabala, Xavier, additional, Lendoire, Javier, additional, Maithel, Shishir, additional, Branes, Alejandro, additional, Andersson, Bodil, additional, Serrablo, Alejandro, additional, Adsay, Volkan, additional, Abe, Tomoyuki, additional, Abu Hilal, Moh'd, additional, Achalandabaso Boira, Maria del Mar, additional, Adham, Mustapha, additional, Adam, Mohamed, additional, Ahmad, Maryam, additional, Al-Sarireh, Bilal, additional, Albiol, Maite, additional, Alhaboob, Nassir, additional, Alseidi, Adnan, additional, Ammar, Houssem, additional, Anand, Akshay, additional, Antonakis, Pantelis, additional, Araya, Veronica, additional, Ashley, Stanley W., additional, Atanasov, Georgi, additional, Ausania, Fabio, additional, Balestri, Ricardo, additional, Banerjee, Abhirup, additional, Banerjee, Sudeep, additional, Banting, Simon, additional, Barauskas, Giedrius, additional, Bartsch, Fabian, additional, Belli, Andrea, additional, Beretta, Simona, additional, Berrevoet, Frederik, additional, Bhandari, Ramesh Singh, additional, Blanco Fernandez, Gerardo, additional, Bolm, Louisa, additional, Bonal, Mathieu, additional, Bozkurt, Emre, additional, Braat, Andries E., additional, Bradshaw, Luke, additional, Bramis, Konstantinos, additional, Burdine, Lyle, additional, Byrne, Matthew, additional, Caceres, Maria, additional, Castro Santiago, Maria Jesus, additional, Chan, Benjamin, additional, Chong, Lynn, additional, Çoker, Ahmet, additional, Conde Rodriguez, Maria, additional, Croagh, Daniel, additional, Crutchley, Alyn, additional, Cutolo, Carmen, additional, D'Hondt, Mathieu, additional, D'Souza, Daniel, additional, Daams, Freek, additional, Dalla Valle, Raffaele, additional, Davide, José, additional, de Bellis, Mario, additional, de Boer, Marieke, additional, de Meyere, Celine, additional, de Reuver, Philip, additional, Dixon, Matthew, additional, Dorovinis, Panagiotis, additional, Echeverría Bauer, Gabriela, additional, Eduarda, Maria, additional, Eker, Hasan, additional, Erdmann, Joris, additional, Erkan, Mert, additional, Felekouras, Evangelos, additional, Felli, Emanuele, additional, Fernandes, Eduardo, additional, Figueroa Rivera, Eduardo, additional, Fulop, Andras, additional, Galun, Daniel, additional, Gerhards, Michael, additional, Ghorbani, Poya, additional, Giannone, Fabio, additional, Gil, Luis, additional, Giorgakis, Emmanouil, additional, Giuffrida, Mario, additional, Giuliante, Felice, additional, Gkekas, Ioannis, additional, Gomez Bravo, Miguel, additional, Groot Koerkamp, Bas, additional, Guevara, Oscar, additional, Guglielmi, Alfredo, additional, Gulla, Aiste, additional, Gupta, Rahul, additional, Gupta, Amit, additional, Gutiérrez, Marta, additional, Hafeez Bhatti, Abu Bakar, additional, Hagendoorn, Jeroen, additional, Hajee, Zain, additional, Hakeem, Abdul Rahman, additional, Hamid, Hytham, additional, Hassen, Sayed, additional, Heinrich, Stefan, additional, Higuchi, Ryota, additional, Hoffman, Daniel, additional, Holroyd, David, additional, Hughes, Daniel, additional, Ivanecz, Arpad, additional, Iype, Satheesh, additional, Jaen Torrejimeno, Isabel, additional, Joglekar, Shantanu, additional, Jones, Robert, additional, Kaczirek, Klaus, additional, Kanhere, Harsh, additional, Kausar, Ambareen, additional, Kee, Zhanyi, additional, Keilson, Jessica, additional, Kleef, Jorg, additional, Klose, Johannes, additional, Knowles, Brett, additional, Koong, Jun Kit, additional, Kumar, Nagappan, additional, Kunnuru, Supreeth, additional, Lakhey, Paleswan Joshi, additional, Laurenzi, Andrea, additional, Lee, Yeong Sing, additional, Leon, Felipe, additional, Leow, Voon Meng, additional, Lequeu, Jean-Baptiste, additional, Lesurtel, Mickael, additional, Lo, Elisabeth, additional, Löb, Stefan, additional, Lockie, Elizabeth, additional, Lodge, Peter, additional, López Garnica, Dolores, additional, Lopez Lopez, Victor, additional, Lundgren, Linda, additional, Machairas, Nikolaos, additional, Maharjan, Dhiresh, additional, Malde, Deep, additional, Martel, Guillaume, additional, Martin, Julie, additional, Mazzola, Michele, additional, Mehrabi, Arianeb, additional, Memeo, Ricardo, additional, Milana, Flavio, additional, Molina, George, additional, Monette, Leah, additional, Morgul, Haluk, additional, Moris, Dimitrios, additional, Morsi-Yeroyannis, Antonios, additional, Mowbray, Nicholas, additional, Mulita, Francesk, additional, Muttillo, Edoardo Maria, additional, Nandasena, Malith, additional, Nashidengo, Pueya Rashid, additional, Nickkholgh, Arash, additional, Noel, Colin Byron, additional, Ohtsuka, Masayuki, additional, Ozolins, Arturs, additional, Pandanaboyana, Sanjay, additional, Pararas, Nikolaos, additional, Parente, Alessandro, additional, Peng, June, additional, Perfecto Valero, Arkaitz, additional, Perinel, Julie, additional, Perivoliotis, Konstatinos, additional, Perra, Teresa, additional, Pessaux, Patrick, additional, Petruch, Natalie, additional, Piccolo, Gaetano, additional, Piros, Laszlo, additional, Porcu, Alberto, additional, Prabakaran, Viswakumar, additional, Prasad, Raj, additional, Prieto Calvo, Mikel, additional, Primavesi, Florian, additional, Pueyo Periz, Eva Maria, additional, Quaglia, Alberto, additional, Ramia Angel, Jose M., additional, Rammohan, Ashwin, additional, Razionale, Francesco, additional, Robles Campos, Ricardo, additional, Roy, Manas, additional, Rozwadowski, Sophie, additional, Ruffolo, Luis, additional, Ruiz, Natalia, additional, Ruzzenante, Andrea, additional, Saadat, Lily, additional, Said, Mohamed Amine, additional, Saladino, Edoardo, additional, Saliba, Gabriel, additional, Sandstrom, Per, additional, Schena, Carlo Alberto, additional, Scholer, Anthony, additional, Schwarz, Christoph, additional, Serafini, Lorenzo, additional, Serrano, Pablo E., additional, Sharma, Deepak, additional, Sheen, Aali, additional, Siddagangaiah, Vishwanath, additional, Silva, Michael, additional, Singh, Saurabh, additional, Siriwardena, Ajith, additional, Skalski, Michal, additional, Smig, Mante, additional, Soliman, Faris, additional, Sonkar, Abhinav Arun, additional, Sousa Silva, Donzília, additional, Sparrelid, Ernesto, additional, Srinivasan, Parthi, additional, Sternby Eilard, Malin, additional, Strobel, Oliver, additional, Stupan, Urban, additional, Suarez-Munoz, Miguel Angel, additional, Subramaniam, Manisekar, additional, Sugiura, Teiichi, additional, Sutcliffe, Robert, additional, Swank, Hilko, additional, Taylor, Lillian, additional, Thapa, Prabin Bikram, additional, The, Catherine, additional, Thepbunchonchai, Asara, additional, Thieu, Caman, additional, Tiwari, Navneet, additional, Torzilli, Guido, additional, Tovikkai, Chutwichai, additional, Trotovsek, Blaz, additional, Tsaramanidis, Savvas, additional, Tsoulfas, Georgios, additional, Uesaka, Katsuhiko, additional, Umar, Garzali, additional, Urbani, Lucio, additional, Vailas, Michail, additional, van Dam, Ronald, additional, van de Boezem, Peter, additional, van Laarhoven, Stijn, additional, Vanagas, Tomas, additional, Van Dooren, Mike, additional, Viennet, Manon, additional, Vigano, Luca, additional, Vijayashanker, Aarathi, additional, Villodre, Celia, additional, Wakai, Toshifumi, additional, Workneh, Aklile, additional, Xu, Li, additional, Yamamoto, Masakazu, additional, Yang, Zhiying, additional, Young, Robert, additional, and Zivanovic, Marko, additional

Published
2023
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35. Status of CHIP-TRAP: The Central Michigan University High-Precision Penning Trap.

Author

Redshaw, Matthew, Bhandari, Ramesh, Gamage, Nadeesha, Hasan, Mehedi, Gamage, Madhawa Horana, Keblbeck, Dakota K., Limarenko, Savannah, and Perera, Dilanka

Subjects
ATOMIC mass, PARTICLE physics, NUCLEAR structure, ION traps, NEUTRINOS, MASS measurement, ION sources
Abstract

Precise and accurate atomic mass data provide crucial information for applications in a wide range of fields in physics and beyond, including astrophysics, nuclear structure, particle and neutrino physics, fundamental symmetries, chemistry, and metrology. The most precise atomic mass measurements are performed on charged particles confined in a Penning trap. Here, we describe the development, status, and outlook of CHIP-TRAP: the Central Michigan University high-precision Penning trap. CHIP-TRAP aims to perform ultra-high precision (∼1 part in 10 11 fractional precision) mass measurements on stable and long-lived isotopes produced with external ion sources and transported to the Penning traps. Along the way, ions of a particular m / q are selected with a multi-reflection time-of-flight mass separator (MR-TOF-MS), with further filtering performed in a cylindrical capture trap before the ions are transported to a pair of hyperbolic measurement traps. In this paper, we report on the design and status of CHIP-TRAP and present results from the commissioning of the ion sources, MR-TOF-MS, and capture trap. We also provide an outlook on the continued development and commissioning of CHIP-TRAP. [ABSTRACT FROM AUTHOR]

Published
2023
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40. LINC01023 Promotes the Hepatoblastoma Tumorigenesis via miR-378a-5p/WNT3 Axis.

Author

Bhandari, Ramesh, Shaikh, Imran Ibrahim, Bhandari, Rajeev, and Chapagain, Sadikchha

Abstract

Hepatoblastoma is the most common type of hepatic tumors occurring in children between 0 and 5 years. And the exact pathophysiology of the disease is still mysterious. Accumulating studies on LncRNA have shown its pivotal role in the development and progression of distinct human cancers. However, the role of LINC01023 in hepatoblastoma is unknown. The relative expression of LINC01023, miR-378a-5p, and Wnt3 on hepatoblastoma tissue and cell lines was determined by quantitative polymerase chain reaction (qRT-PCR). The effect of LINC01023 downregulation and upregulation on cell proliferation, colony formation and apoptosis activities in HUH6 and HepG2 Cells was assessed by CKK8, clonogenic and flow cytometry analysis, respectively. Dual luciferase, RNA immunoprecipitation (RIP), and RNA pull-down were performed to confirm the interaction between LINC01023 and miR-378a-5p. Similarly, Dual luciferase assay was performed to confirmed the interaction between Wnt3 and miR-378a-5p. The xenograft tumorgenicity test was performed to elucidate the tumorgenicity potential of LINC01023. LINC01023 was significantly upregulated in hepatoblastoma tissue and cell lines rather than in adjacent normal hepatic tissue and QSG7701 cell lines. LINC01023 silencing attenuated cell proliferation, colony formation and increased cell apoptosis. Conversely, LINC01023 upregulation results in significant increase in cell proliferation, and colony formation activities however, a significant reduction in apoptosis activity was reported. Interaction between the LINC01023 and WNT3 was confirmed by dual luciferase assay. Xenograft animal tumorgenicity test confirmed the in-vivo tumorigenesis potential of LINC01203. To the best of our knowledge, this study is the first study demonstrating the role of LINC01023 in hepatoblastoma tumorigenesis through the LINC01023/miR-378a-5p/Wnt3 axis. It could be a potential therapeutic target and a prognostic biomarker in hepatoblastoma. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Primary Duodenal Adenocarcinoma: Uncommon Tumor, Uncommon Presentation. A Case Report and Review of the Literature

Author

Khanal, Shital, Joshi, Utsav, Bhattarai, Adheesh, Agrawal, Vishakha, Sayami, Gita, and Bhandari, Ramesh Singh

Subjects
first part, non-stenotic lesion, Case Report, duodenum, primary duodenal adenocarcinoma
Abstract

Introduction The symptoms of primary duodenal adenocarcinoma, which is a rare but aggressive tumor, are vague and nonspecific and often result in a delayed diagnosis or misdiagnosis. This results in a tumor being diagnosed at an advanced stage when it becomes unresectable secondary to local and distant spread. Case Presentation A 64-year-old Nepalese female presented to our hospital with epigastric pain, anorexia, and significant weight loss that developed over two-and-a-half months. Upper gastrointestinal endoscopy showed an ulceroproliferative growth in the first part of the duodenum with no features of duodenal stenosis. Contrast- enhanced computed tomography of the abdomen revealed heterogeneously enhancing, circumferential, asymmetrical thickening in the first part of the duodenum and multiple liver metastases. Biopsy of the mass revealed features suggestive of moderately differentiated adenocarcinoma of the duodenum. She was managed with palliative care during her hospital stay. The unique presentation in our case was that the tumor did not cause stenosis and the patient could consume food till the last day of her life. Conclusion In patients with primary duodenal adenocarcinoma, the non-stenotic lesion is also a possibility. Clinicians should always maintain a high degree of suspicion to avoid the delay in diagnosis or misdiagnosis.

Published
2020

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