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44 results on '"Bharatham, Nagakumar"'

1. BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections

Author

Hameed P, Shahul, Kotakonda, Harish, Sharma, Sreevalli, Nandishaiah, Radha, Katagihallimath, Nainesh, Rao, Ranga, Sadler, Claire, Slater, Ian, Morton, Michael, Chandrasekaran, Abhijeeth, Griffen, Ed, Pillai, Dhanashree, Reddy, Sambasiva, Bharatham, Nagakumar, Venkatesan, Suryanarayanan, Jonnalagadda, Venugopal, Jayaraman, Ramesh, Nanjundappa, Mahesh, Sharma, Maitrayee, Raveendran, Savitha, Rajagopal, Sreenath, Tumma, Harikrishna, Watters, Amy, Becker, Holly, Lindley, Jill, Flamm, Robert, Huband, Michael, Sahm, Dan, Hackel, Meredith, Mathur, Tarun, Kolamunnage-Dona, Ruwanthi, Unsworth, Jennifer, Mcentee, Laura, Farrington, Nikki, Manickam, Dhanasekaran, Chandrashekara, Narayana, Jayachandiran, Sivakandan, Reddy, Hrushikesava, Shanker, Sathya, Richard, Vijay, Thomas, Teby, Nagaraj, Savitha, Datta, Santanu, Sambandamurthy, Vasan, Ramachandran, Vasanthi, Clay, Robert, Tomayko, John, Das, Shampa, and V, Balasubramanian

Published
2024
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6. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.

Author

He, Shanshan, Ni, Duojiao, Ma, Binyun, Lee, Joo-Hyung, Zhang, Tian, Ghozalli, Irene, Pirooz, Sara, Zhao, Zhen, Bharatham, Nagakumar, Li, Baihong, Oh, Soohwan, Takahashi, Yoshinori, Wang, Hong-Gang, Minassian, Arlet, Feng, Pinghui, Deretic, Vojo, Pepperkok, Rainer, Tagaya, Mitsuo, Yoon, Ho, Liang, Chengyu, and Lee, Wen-Hwa

Subjects
Amino Acid Sequence, Animals, Apoptosis Regulatory Proteins, Autophagy, Autophagy-Related Proteins, Beclin-1, Biological Transport, COS Cells, Cell Line, Cells, Cultured, Endoplasmic Reticulum, Golgi Apparatus, HEK293 Cells, HeLa Cells, Humans, Membrane Proteins, Mice, Models, Molecular, Molecular Sequence Data, Phosphatidylinositols, Protein Binding, Protein Structure, Tertiary, Sequence Alignment, Tumor Suppressor Proteins, Vesicular Transport Proteins
Abstract

Endoplasmic reticulum (ER)-Golgi membrane transport and autophagy are intersecting trafficking pathways that are tightly regulated and crucial for homeostasis, development and disease. Here, we identify UVRAG, a beclin-1-binding autophagic factor, as a phosphatidylinositol-3-phosphate (PtdIns(3)P)-binding protein that depends on PtdIns(3)P for its ER localization. We further show that UVRAG interacts with RINT-1, and acts as an integral component of the RINT-1-containing ER tethering complex, which couples phosphoinositide metabolism to COPI-vesicle tethering. Displacement or knockdown of UVRAG profoundly disrupted COPI cargo transfer to the ER and Golgi integrity. Intriguingly, autophagy caused the dissociation of UVRAG from the ER tether, which in turn worked in concert with the Bif-1-beclin-1-PI(3)KC3 complex to mobilize Atg9 translocation for autophagosome formation. These findings identify a regulatory mechanism that coordinates Golgi-ER retrograde and autophagy-related vesicular trafficking events through physical and functional interactions between UVRAG, phosphoinositide and their regulatory factors, thereby ensuring spatiotemporal fidelity of membrane trafficking and maintenance of organelle homeostasis.

Published
2013

10. Data from Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

Author

Slavish, P. Jake, primary, Chi, Liying, primary, Yun, Mi-Kyung, primary, Tsurkan, Lyudmila, primary, Martinez, Nancy E., primary, Jonchere, Barbara, primary, Chai, Sergio C., primary, Connelly, Michele, primary, Waddell, M. Brett, primary, Das, Sourav, primary, Neale, Geoffrey, primary, Li, Zhenmei, primary, Shadrick, William R., primary, Olsen, Rachelle R., primary, Freeman, Kevin W., primary, Low, Jonathan A., primary, Price, Jeanine E., primary, Young, Brandon M., primary, Bharatham, Nagakumar, primary, Boyd, Vincent A., primary, Yang, Jun, primary, Lee, Richard E., primary, Morfouace, Marie, primary, Roussel, Martine F., primary, Chen, Taosheng, primary, Savic, Daniel, primary, Guy, R. Kiplin, primary, White, Stephen W., primary, Shelat, Anang A., primary, and Potter, Philip M., primary

Published
2023
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11. Supplementary Data from Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

Author

Slavish, P. Jake, primary, Chi, Liying, primary, Yun, Mi-Kyung, primary, Tsurkan, Lyudmila, primary, Martinez, Nancy E., primary, Jonchere, Barbara, primary, Chai, Sergio C., primary, Connelly, Michele, primary, Waddell, M. Brett, primary, Das, Sourav, primary, Neale, Geoffrey, primary, Li, Zhenmei, primary, Shadrick, William R., primary, Olsen, Rachelle R., primary, Freeman, Kevin W., primary, Low, Jonathan A., primary, Price, Jeanine E., primary, Young, Brandon M., primary, Bharatham, Nagakumar, primary, Boyd, Vincent A., primary, Yang, Jun, primary, Lee, Richard E., primary, Morfouace, Marie, primary, Roussel, Martine F., primary, Chen, Taosheng, primary, Savic, Daniel, primary, Guy, R. Kiplin, primary, White, Stephen W., primary, Shelat, Anang A., primary, and Potter, Philip M., primary

Published
2023
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12. Author Correction: BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections.

Author

Hameed P, Shahul, Kotakonda, Harish, Sharma, Sreevalli, Nandishaiah, Radha, Katagihallimath, Nainesh, Rao, Ranga, Sadler, Claire, Slater, Ian, Morton, Michael, Chandrasekaran, Abhijeeth, Griffen, Ed, Pillai, Dhanashree, Reddy, Sambasiva, Bharatham, Nagakumar, Venkatesan, Suryanarayanan, Jonnalagadda, Venugopal, Jayaraman, Ramesh, Nanjundappa, Mahesh, Sharma, Maitrayee, and Raveendran, Savitha

Subjects
DRUG resistance in bacteria, MULTIDRUG resistance, CHILDREN'S hospitals, BURKHOLDERIA cepacia, GRAM-negative bacteria
Abstract

Nature Communications published a correction notice for an article titled "BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections." The correction addressed errors in the Acknowledgements section, specifically in acknowledging individuals and work from various institutions. The corrected version now properly acknowledges the contributions of multiple researchers and institutions involved in the study. [Extracted from the article]

Published
2025
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18. Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria

Author

Sharma, Sreevalli, primary, Rao, Ranga, additional, Reeve, Stephanie M., additional, Phelps, Gregory A., additional, Bharatham, Nagakumar, additional, Katagihallimath, Nainesh, additional, Ramachandran, Vasanthi, additional, Raveendran, Savitha, additional, Sarma, Maitrayee, additional, Nath, Anubha, additional, Thomas, Teby, additional, Manickam, Dhanasekaran, additional, Nagaraj, Savitha, additional, Balasubramanian, V., additional, Lee, Richard E., additional, Hameed P, Shahul, additional, and Datta, Santanu, additional

Published
2021
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25. Combating Multidrug‐Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling

Author

Lang, Yinzhi, primary, Shah, Nirav R., additional, Tao, Xun, additional, Reeve, Stephanie M., additional, Zhou, Jieqiang, additional, Moya, Bartolome, additional, Sayed, Alaa R. M., additional, Dharuman, Suresh, additional, Oyer, Jeremiah L., additional, Copik, Alicja J., additional, Fleischer, Brett A., additional, Shin, Eunjeong, additional, Werkman, Carolin, additional, Basso, Kari B., additional, Deveson Lucas, Deanna, additional, Sutaria, Dhruvitkumar S., additional, Mégroz, Marianne, additional, Kim, Tae Hwan, additional, Loudon‐Hossler, Victoria, additional, Wright, Amy, additional, Jimenez‐Nieves, Rossie H., additional, Wallace, Miranda J., additional, Cadet, Keisha C., additional, Jiao, Yuanyuan, additional, Boyce, John D., additional, LoVullo, Eric D., additional, Schweizer, Herbert P., additional, Bonomo, Robert A., additional, Bharatham, Nagakumar, additional, Tsuji, Brian T., additional, Landersdorfer, Cornelia B., additional, Norris, Michael H., additional, Soo Shin, Beom, additional, Louie, Arnold, additional, Balasubramanian, Venkataraman, additional, Lee, Richard E., additional, Drusano, George L., additional, and Bulitta, Jürgen B., additional

Published
2021
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27. Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

Author

Slavish, P. Jake, primary, Chi, Liying, additional, Yun, Mi-Kyung, additional, Tsurkan, Lyudmila, additional, Martinez, Nancy E., additional, Jonchere, Barbara, additional, Chai, Sergio C., additional, Connelly, Michele, additional, Waddell, M. Brett, additional, Das, Sourav, additional, Neale, Geoffrey, additional, Li, Zhenmei, additional, Shadrick, William R., additional, Olsen, Rachelle R., additional, Freeman, Kevin W., additional, Low, Jonathan A., additional, Price, Jeanine E., additional, Young, Brandon M., additional, Bharatham, Nagakumar, additional, Boyd, Vincent A., additional, Yang, Jun, additional, Lee, Richard E., additional, Morfouace, Marie, additional, Roussel, Martine F., additional, Chen, Taosheng, additional, Savic, Daniel, additional, Guy, R. Kiplin, additional, White, Stephen W., additional, Shelat, Anang A., additional, and Potter, Philip M., additional

Published
2020
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30. Correction: Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization

Author

Choi, Bo-Hwa, primary, Chattopadhaya, Souvik, additional, Thanh, Le Nguyen, additional, Feng, Lin, additional, Nguyen, Quoc Toan, additional, Lim, Chuan Bian, additional, Harikishore, Amaravadhi, additional, Nanga, Ravi Prakash Reddy, additional, Bharatham, Nagakumar, additional, Zhao, Yan, additional, Liu, Xuewei, additional, and Yoon, Ho Sup, additional

Published
2018
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31. Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy

Author

Hameed P, Shahul, primary, Bharatham, Nagakumar, additional, Katagihallimath, Nainesh, additional, Sharma, Sreevalli, additional, Nandishaiah, Radha, additional, Shanbhag, Anirudh P., additional, Thomas, Teby, additional, Narjari, Riya, additional, Sarma, Maitrayee, additional, Bhowmik, Purnendu, additional, Amar, Prakruthi, additional, Ravishankar, Rajani, additional, Jayaraman, Ramesh, additional, Muthan, Kubendran, additional, Subbiah, Ramesh, additional, Ramachandran, Vasanthi, additional, Balasubramanian, V., additional, and Datta, Santanu, additional

Published
2018
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33. Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization

Author

Choi, Bo-Hwa, primary, Chattopadhaya, Souvik, additional, Thanh, Le Nguyen, additional, Feng, Lin, additional, Nguyen, Quoc Toan, additional, Lim, Chuan Bian, additional, Harikishore, Amaravadhi, additional, Nanga, Ravi Prakash Reddy, additional, Bharatham, Nagakumar, additional, Zhao, Yan, additional, Liu, Xuewei, additional, and Yoon, Ho Sup, additional

Published
2014
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40. Molecular Docking Study of Aminoacyl-tRNA Synthetases with Ligand Molecules from Four Different Scaffolds

Author

Bharatham, Nagakumar, primary, Bharatham, Kavitha, additional, Lee, Yu-No, additional, Kim, Song-Mi, additional, Lazar, Prettina, additional, Baek, A-Young, additional, Park, Chan-In, additional, Eum, Hee-Sung, additional, Ha, Hyun-Joon, additional, Yun, Sae-Young, additional, Lee, Won-Koo, additional, Kim, Sung-Hoon, additional, and Lee, Keun-Woo, additional

Published
2010
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44. Mechanistic insights into non-immunosuppressive immunophilin ligands as potential antimalarial therapeutics.

Author

Ho Sup Yoon, Alag, Reema, Congbao Kang, Hong Ye, Kotaka, Masayo, Qureshi, Insaf A., Bharatham, Nagakumar, Shin, Joon, Bozdech, Zbynek, Preiser, Peter, and Lescar, Julien

Subjects
ANTIMALARIALS, IMMUNOSUPPRESSIVE agents
Abstract

The article presents an abstract of the article "Mechanistic Insights Into Non-Immunosuppressive Immunophilin Ligands As Potential Antimalarial Therapeutics," by Ho Sup Yoon, Reema Alag and colleagues, presented at the conference "Parasite to Prevention: Advances in the Understanding of Malaria" held in Edinburgh, Great Britain from October 20-22, 2010.

Published
2010
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