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1. R-matrix with time-dependence calculations for three-sideband RABBITT in helium

Author

Bondy, A. T., del Valle, J. C., Saha, S., Hamilton, K. R., Bharti, D., Harth, A., and Bartschat, K.

Subjects
Physics - Atomic Physics, Physics - Computational Physics
Abstract

Following up on a recent paper [Bharti et al., Phys. Rev. A 109 (2024) 023110], we compare the predictions from severalR-matrix with time-dependence calculations for a modified three-sideband version of the "reconstruction of attosecond beating by interference of two-photon transitions" (RABBITT) configuration applied to helium. Except for the special case of the threshold sideband, which appears to be very sensitive to the details of coupling to the bound Rydberg states, increasing the number of coupled states in the close-coupling expansion used to describe the ejected-electron--residual-ion interaction hardly changes the results. Consequently, the remaining discrepancies between the experimental data and the theoretical predictions are likely due to uncertainties in the experimental parameters, particularly the detailed knowledge of the laser pulse.

Published
2024

3. Multi-sideband interference structures by high-order photon-induced continuum-continuum transitions in helium

Author

Bharti, D., Srinivas, H., Shobeiry, F., Bondy, A. T., Saha, S., Hamilton, K. R., Moshammer, R., Pfeifer, T., Bartschat, K., and Harth, A.

Subjects
Physics - Atomic Physics
Abstract

Following up on a previous paper on two-color photoionization of Ar(3p) [Bharti et al., Phys. Rev. A 103 (2021) 022834], we present measurements and calculations for a modified three-sideband (3-SB) version of the "reconstruction of attosecond beating by interference of two-photon transitions" (RABBITT) configuration applied to He(1s). The 3-SB RABBITT approach allows us to explore interference effects between pathways involving different orders of transitions within the continuum. The relative differences in the retrieved oscillation phases of the three sidebands provide insights into the continuum-continuum transitions. The ground state of helium has zero orbital angular momentum, which simplifies the analysis of oscillation phases and their angle-dependence within the three sidebands. We find qualitative agreement between our experimental results and the theoretical predictions for many cases but also observe some significant quantitative discrepancies., Comment: 9 pages, 6 figures

Published
2023

4. Multi-Sideband RABBIT in Argon

Author

Bharti, D, Srinivas, H, Shobeiry, F, Hamilton, K R, Moshammer, R, Pfeifer, T, Bartschat, K, and Harth, A

Subjects
Physics - Atomic Physics, Quantum Physics
Abstract

We report a joint experimental and theoretical study of a three-sideband (3-SB) modification of the "reconstruction of attosecond beating by interference of two-photon transitions" (RABBIT) setup. The 3-SB RABBIT scheme makes it possible to investigate phases resulting from interference between transitions of different orders in the continuum. Furthermore, the strength of this method is its ability to focus on the atomic phases only, independent of a chirp in the harmonics, by comparing the RABBIT phases extracted from specific SB groups formed by two adjacent harmonics. We verify earlier predictions that the phases and the corresponding time delays in the three SBs extracted from angle-integrated measurements become similar with increasing photon electron energy. A variation in the angle dependence of the RABBIT phases in the three SBs results from the distinct Wigner and continuum-continuum coupling phases associated with the individual angular momentum channels. A qualitative explanation of this dependence is attempted by invoking a propensity rule. Comparison between the experimental data and predictions from an R-matrix (close-coupling) with time dependence calculation shows qualitative agreement in the observed trends., Comment: 8 pages, 5 figures

Published
2022

5. Fractional Order Particle Swarm Optimization to Optimize a Fractional Order PID Controller for a Vertical Take-Off and Landing System

Author

Acharya, D. S., Mishra, S. K., Sarkar, B., Bharti, D., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Reddy, M. Jaya Bharata, editor, Mohanta, Dusmanta Kr., editor, Kumar, Deepak, editor, and Ghosh, Debomita, editor

Published
2021
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14. Genetic diversity varies with species traits and latitude in predatory soil arthropods (Myriapoda: Chilopoda).

Author

Bharti, D. K., Pawar, Pooja Yashwant, Edgecombe, Gregory D., and Joshi, Jahnavi

Subjects
*GENETIC variation, *SPECIES diversity, *ANIMAL diversity, *MYRIAPODA, *CYTOCHROME oxidase, *TRACE fossils
Abstract

Aim: To investigate the drivers of intra‐specific genetic diversity in centipedes, a group of ancient predatory soil arthropods. Location: Asia, Australasia and Europe. Time Period: Present. Major Taxa Studied: Centipedes (Class: Chilopoda). Methods: We assembled a database of 1245 mitochondrial cytochrome c oxidase subunit I sequences representing 128 centipede species from all five orders of Chilopoda. This sequence dataset was used to estimate genetic diversity for centipede species and compare its distribution with estimates from other arthropod groups. We studied the variation in centipede genetic diversity with species traits and biogeography using a beta regression framework, controlling for the effect of shared evolutionary history within a family. Results: A wide variation in genetic diversity across centipede species (0–0.1713) falls towards the higher end of values among arthropods. Overall, 27.57% of the variation in mitochondrial COI genetic diversity in centipedes was explained by a combination of predictors related to life history and biogeography. Genetic diversity decreased with body size and latitudinal position of sampled localities, was greater in species showing maternal care and increased with geographic distance among conspecifics. Main Conclusions: Centipedes fall towards the higher end of genetic diversity among arthropods, which may be related to their long evolutionary history and low dispersal ability. In centipedes, the negative association of body size with genetic diversity may be mediated by its influence on local abundance or the influence of ecological strategy on long‐term population history. Species with maternal care had higher genetic diversity, which goes against expectations and needs further scrutiny. Hemispheric differences in genetic diversity can be due to historic climatic stability and lower seasonality in the southern hemisphere. Overall, we find that despite the differences in mean genetic diversity among animals, similar processes related to life‐history strategy and biogeography are associated with the variation within them. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Acute Reversal of Warfarin Therapy in Patient with Protein C and S Deficiency Presenting for Emergency Surgery

Author

Sananta kumar Dash, Harshel G Parikh, Saurabh B Tiwari, and Bharti D Kondwilkar

Subjects
Protein C, Protein S, Deficiency, Warfarin Reversal, Emergency Surgery, Anesthesiology, RD78.3-87.3
Abstract

This is a case report of a 19 year young male presented with swelling and blackening of right upper limb and abdominal pain since 10 days. He was a known case of protein C and protein S deficiency on warfarin therapy, with deranged coagulation parameters posted for amputation fingers in emergency

Published
2010

22. Accelerated weathering performance of injection moulded PP and LDPE composites reinforced with calcium rich waste resources

Author

Bakshi, P., Pappu, A., Bharti, D. et al., Bakshi, P., Pappu, A., and Bharti, D. et al.

Abstract

This study aims to assess and understand the accelerated weathering performance of injection moulded PP and LDPE composites reinforced with calcium rich waste resources for the first time. Two different calcium rich wastes: FGD gypsum and marble waste are incorporated without any chemical treatment in the polymer matrices. Visual appearance, chemical changes, flexural properties (strength, modulus and elongation) and surface morphology are analysed. Weathered surfaces are studied to analyse the structural changes with morphology by FTIR and SEM. LDPE showed higher visual stability by weathering with enhanced flexural properties for FGD gypsum composites. FTIR analysis revealed that the composites prepared with LDPE had a stabilizing effect on photo-degradation (minimum carbonyl index=1.09–1.14), which correlates well with the results of mechanical testing, showing these composites retained remarkable mechanical properties (retention rate>85%.) after weathering. Visual appearances, physical and mechanical properties of polymer composites are affected by the accelerated weathering condition. UV radiation in combination with temperature, humidity and water spray leads to polymer crystallinity with degradation resulting in weaker interfacial bonding and detachment of filler from matrix. Results show that the flexural strength of weathered FGD gypsum-PP, marble waste-PP and marble waste-LDPE composites decreased about 7–38%, 50–59% and 5–6%, respectively. Flexural strength of the weathered FGD gypsum-LDPE composites increased about 7–12%. The present study implies that both the reinforcements can enhance the properties of PP and LDPE composites after accelerated UV weathering exposure with potential for civil engineering applications. FGD gypsum is more prominent while structural and durability performances are taken into account.

Published
2021

28. Environmental correlates of distribution across spatial scales in the intertidal gastropods Littoraria and Echinolittorina of the Indian coastline.

Author

Bharti, D K and Shanker, Kartik

Subjects
*COASTS, *MARINE habitats, *GASTROPODA, *OCEAN currents, *SPECIES distribution, *INTERTIDAL zonation, *ADULTS
Abstract

Marine habitats are a mosaic of environmental conditions, which can limit species distributions despite the high dispersal potential offered by ocean currents. Periwinkle snails from the genera Littoraria and Echinolittorina disperse using planktotrophic larvae and have wide ranges in the Indo-Pacific, but patchy local distributions along the Indian coastline. To understand the environmental drivers of distribution in these intertidal snails, we used species distribution models executed in Maxent at both coastline and ocean basin scales. We obtained location information from primary and secondary sources, and used environmental predictors related to species survival, growth and reproduction spanning terrestrial and marine realms. Explanatory environmental variables broadly corresponded between scales, with maximum sea surface salinity and tidal range being common factors across species differing in their dispersal potential and habitat specificity. The Indian coastline exhibits a steep salinity and tidal range gradient, which may influence adult or larval survival through desiccation stress. In contrast to global-scale studies, temperature and productivity rarely emerged as important at the Indian coastline scale, indicating that variation along other environmental axes can drive distribution patterns at smaller spatial scales and within tropical coastlines. The results from our study provide specific hypotheses related to species-environment relationships that can be tested using field experiments to understand the drivers of species range along the Indian coastline. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Study of the Complexation Behaviour of Fexofenadine with β-Cyclodextrin

Author

KP Bhusari, Bharti D Shewale, Daud Anwar Siraj, Nidhi Sapkal, and Vaishali Kilor

Subjects
Molar, chemistry.chemical_classification, Chromatography, Fexofenadine, Cyclodextrin, Coprecipitation, Pharmaceutical Science, Infrared spectroscopy, Liquid state, chemistry, β-cyclodextrin, Phase (matter), medicine, co-precipitation, Solubility, fexofenadine, inclusion complexes, kneading, Nuclear chemistry, medicine.drug, Research Paper
Abstract

Fexofenadine is a selective histamine H(1) receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spectroscopy, X-ray diffractometry, and in vitro dissolution studies. Fexofenadine was found to exhibit interaction with β-cyclodextrin both in solid and liquid state. Phase solubility studies indicated that fexofenadine forms a stable complex with β-cyclodextrin. Both IR spectroscopy and X-ray diffractometry studies indicated interaction of fexofenadine with β-cyclodextrin. Kneading method at 1:1 and co-precipitation method at 1:1 and 1:2 molar ratios showed significant interaction. In vitro dissolution studies confirmed the same results.

Published
2010

32. Effect of hydroxylpropyl-β-cyclodextrin on Solubility of Carvedilol

Author

NA Raut, Ravindra A. Fursule, Nidhi Sapkal, NJ Gaikwad, and Bharti D Shewale

Subjects
chemistry.chemical_classification, Cyclodextrin, Chemistry, pH, hydroxypropyl-β-cyclodextrin, solubility, Inorganic chemistry, technology, industry, and agriculture, Short Communications, Pharmaceutical Science, Protonation, Bioavailability, carbohydrates (lipids), stomatognathic system, polycyclic compounds, medicine, Molecule, Organic chemistry, Carvedilol, Solubility, Beta (finance), bioavailability, Neutral molecule, medicine.drug
Abstract

The present study was undertaken to examine the effect of pH and concentration of hydroxypropyl-beta-cyclodextrin on the solubility of carvedilol as it shows pH-dependent solubility. The equilibrium solubility of carvedilol in a series of solutions of varying pH (from 1.2 to 11) was determined and compared with the equilibrium solubility of carvedilol in the presence of 20% hydroxypropyl-beta-cyclodextrin at same pH values. It was observed that solubility of protonated form is more than neutral molecule. Hydroxypropyl-beta-cyclodextrin resulted in increased solubility at all the pH. But inclusion in the cavity of hydroxypropyl-beta-cyclodextrin might depend upon charge state of the molecule. So it can be concluded that solubility of carvedilol, can be increased either by the addition of hydroxypropyl-beta-cyclodextrin or by adding pH lowering agents. But both these methods if are to be used together, pH should be selected carefully.

Published
2008

33. Formulation and in vitro characterization of metoprolol tartrate loaded chitosan microspheres

Author

Adi, Bharti D., Raj, Keservani K., Anil, Sharma K., Rajesh, Kesharwani K., and Gulam, Husain M.

Subjects
Microphotograph, Chitosan Microspheres, Metoprolol tartrate, Microfotografía, Tartrato de metoprolol, Microesferas de quitosano
Abstract

Aim: The main objective of present study was to facilitate intranasal delivery of Metoprolol tartrate (cardioselective β1-blocker) by formulating mucoadhesive microspheres. Methods: The microspheres were prepared by ionic precipitation and chemical cross-linking method. Microsphere formulations were characterized for particle size, surface morphology, entrapment efficiency, in vitro drug release and Infrared Spectroscopy. Results: The particle size and maximum entrapment of optimized formulation (MT 4) was found to be 1897 nm, 94.19±0.015 %, respectively. In vitro drug release in phosphate buffer saline (pH 7.4) was maximum (97.88±0.02 %) in formulation MF1. The drug release rate can be tailored by manipulating the degree of crystallinity, reduced crystallinity is favorable when slow release is desired. The drug employed can induce polymer chain scission through nucleophilic degradation. The results of the infrared analysis were in agreement with reference as no new chemical species after the microencapsulation process was observed. Conclusions: To conclude, the drug (metoprolol tartrate) thus released in nasal mucosa will attain therapeutic plasma concentration and reduce elevated blood pressure levels., Objetivos: El objetivo principal del presente estudio es el de facilitar la administración intranasal de tartrato de metoprolol (cardioselectivo β1-bloqueante), mediante la formulación de microesferas mucoadhesivas. Métodos: Las microesferas se preparan por precipitación iónica y el método químico de reticulación. Las microesferas se caracterizaron mediante determinación del tamaño de partícula, morfología de la superficie, la eficiencia de atrapamiento, estudio in vitro de la liberación del fármaco y por espectroscopia infrarroja. Resultados: El tamaño de partícula y retención máxima de formulación optimizada (MT 4) fue de 1897 nm y 94,19± 0,015%, respectivamente. La liberación del fármaco in vitro en una solución salina de tampón fosfato (pH=7,4) fue 97,88 ± 0,02% en la formulación de MF1. La tasa de liberación del fármaco puede ser adaptada mediante la manipulación del grado de cristalinidad, la menor cristalinidad favorece una liberación mas lenta. El fármaco empleado puede inducir la escisión de la cadena de polímeros a través de la degradación del nucleófilo. Los resultados de los análisis de infrarrojos no moistraron ningún tipo de alteración producida por el proceso de microencapsulación Conclusiones: el tartrato de metoprolol liberado en la mucosa nasal es aceptable para conseguir reducir los niveles elevados de presión arterial., The present research was provided financial support from all India council for technical education, Delhi.

Published
2012

35. ChemInform Abstract: Novel System for Decarboxylative Bromination of α,β-Unsaturated Carboxylic Acids with Diacetoxyiodobenzene

Author

Pravin O. Patil, Dipak D. Patil, Ravindra A. Fursule, Prashant K. Deshmukh, Bharti D Shewale, and Satish B. Kosalge

Subjects
chemistry.chemical_compound, Chemistry, Bromide, Halogenation, Organic chemistry, General Medicine
Abstract

A simple and mild method for the conversion of varieties of α,β-unsaturated carboxylic acids to the corresponding bromoalkenes using diacetoxyiodobenzene (IBD) in combination with tetraethyl-ammonium bromide (TEAB) at room temperature is discussed. Advantages of this system are short reaction time, easy work up and gave good to excellent yields.

Published
2010
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41. Effect of pH and Hydroxylpropyl-b-Cyclodextrin on Solubility and Stability of Gliclazide

Author

Bharti D Shewale, Nidhi Sapkal, and Ravindra A. Fursule

Subjects
Pharmacology, chemistry.chemical_classification, Aqueous solution, Cyclodextrin, Chemistry, Protonation, General Medicine, Bioavailability, Oral administration, medicine, Gliclazide, Solubility, Neutral molecule, Nuclear chemistry, medicine.drug
Abstract

Purpose: Hydroxy propylated &#946 cyclodextrin (HP-&#946-CD) has been used to improve the aqueous solubility of a variety of pharmacological compounds. Through the complexation of HP-&#946-CD, it is possible to enhance the water solubility and hence the drug bioavailability after oral administration. The present study was undertaken to examine the effect of pH and concentration of HP-&#946-CD on the solubility of gliclazide as it shows pH dependent solubility and stability. Method: The equilibrium solubility of gliclazide in a series of solutions of varying pH (from 1.2 to 11) was determined and compared with the equilibrium solubility of gliclazide in the presence of 20% HP- &#946-CD at same pH values. Result: As the pH increases from 9.2 to 11 its solubility relatively constant (3.5 μg/ml ± 0.5). Addition of 20% HP- -CD increased the solubility to about 9 times at pH 1.2 and 4; 15 times at pH 6.8; 40 times at pH 7.4; 58 times at pH 9.2 and 67 times at pH 11. It was observed that solubility of protonated form is more than neutral molecule. HP-&#946-CD resulted in increased solubility at all pH values. But inclusion of drug in the cavity of HP-&#946-CD might depend upon charged state of the molecule. Conclusion: The solubility of gliclazide can be increased either by the addition of HP-&#946-CD or by adding pH lowering agents. Keywords: pH, hydroxypropylated-&#946-cyclodextrin (HP-&#946-CD), gliclazide.

Published
2009

42. Novel system for decarboxylative bromination of alpha,beta-unsaturated carboxylic acids with diacetoxyiodobenzene

Author

Bharti D Shewale, Dipak D. Patil, Prashant K. Deshmukh, Satish B. Kosalge, Ravindra A. Fursule, and Pravin O. Patil

Subjects
Molecular Structure, Decarboxylation, Iodobenzenes, Carboxylic Acids, Halogenation, Tetraethylammonium, General Chemistry, General Medicine, Hydrocarbons, Brominated, chemistry.chemical_compound, chemistry, Bromide, Drug Discovery, Molecule, Organic chemistry
Abstract

A simple and mild method for the conversion of varieties of alpha,beta-unsaturated carboxylic acids to the corresponding bromoalkenes using diacetoxyiodobenzene (IBD) in combination with tetraethyl-ammonium bromide (TEAB) at room temperature is discussed. Advantages of this system are short reaction time, easy work up and gave good to excellent yields.

Published
2009

43. Development and characterization of enteric-coated immediate-release pellets of aceclofenac by extrusion/spheronization technique using kappa-carrageenan as a pelletizing agent

Author

Bharti D Shewale, Vaishali Kilor, Nidhi Sapkal, and Jasmine G. Awari

Subjects
Diclofenac, Polymers, Chemistry, Pharmaceutical, Pellets, Acrylic Resins, Pharmaceutical Science, Biological Availability, Beta-Cyclodextrins, Lactose, Aquatic Science, Carrageenan, Excipients, Drug Discovery, medicine, Organic chemistry, Solubility, Particle Size, Dissolution, Ecology, Evolution, Behavior and Systematics, Drug Implants, Chromatography, Ecology, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, beta-Cyclodextrins, Povidone, General Medicine, Pelletizing, Enteric coating, Bioavailability, Pharmaceutical Preparations, Aceclofenac, Agronomy and Crop Science, medicine.drug, Research Article
Abstract

In the present study, an attempt was made to prepare immediate-release enteric-coated pellets of aceclofenac, a poorly soluble nonsteroidal anti-inflammatory drug that has a gastrointestinal intolerance as its serious side effect. Formulation of enteric-coated pellets with improved solubility of aceclofenac could address both of these problems. To achieve these goals, pellets were prepared by extrusion-spheronization method using pelletizing agents that can contribute to the faster disintegration and thereby improve the solubility of the drug. Different disintegrants like beta-cyclodextrin, kollidon CL, Ac-Di-Sol, and sodium starch glycolate were tried in order to further improve disintegration time. The pellets were characterized for drug content, particle size distribution, flow properties, infrared spectroscopy, surface morphology, disintegration rate, and dissolution profile. The formulations, which showed best disintegration and dissolution profiles, were coated with Eudragit L100-55, an enteric-coated polymer which does not dissolve at gastric pH but dissolves at intestinal pH, releasing the drug immediately in the dissolution medium. The optimized enteric-coated formulation containing 20% kappa-carrageenan, lactose, and sodium starch glycolate as a disintegrant did inhibit the release of the drug for 2 h in 0.1 N HCl, whereas 87% of the drug was released within 45 min. The improvement was substantial when it was compared with solubility of pure drug under the same conditions. Thus, dissolution profiles suggested that combination of kappa-carrageenan and sodium starch glycolate resulted into fast-disintegrating, immediate-release pellets, overcoming the bioavailability problem of the poorly soluble drug, aceclofenac, and enteric coating of these pellets avoids the exposure of aceclofenac to ulcer-prone areas of the gastrointestinal tract.

Published
2009

48. A Profile of Fundus First Laparoscopic Cholecystectomy.

Author

Singh, Kailash, Thaker, Bharti D., and Kachroo, S. L.

Subjects
*CHOLECYSTECTOMY, *GALLBLADDER surgery, *LAPAROSCOPY, *LAPAROSCOPIC surgery, *ABDOMINAL examination
Abstract

Fundus first laparoscopic cholecystectomy is becoming an option with experienced laparoscopic surgeons to deal with difficult anatomy at Calot's triangle and thereby reducing the conversion rate and rate of complications. Fundus first laparoscopic cholecystectomy was done in 40 patients between three year. There were 26 female & 14 male patients with mean age of 36 years (range 29-64). Reasons for opting for fundus first method were: dense adhesions at Calot's trianglein 26 patients, stones in Hartmann's pouch with short cystic duct 8 , small contracted gall bladder in 4 and Mirizzi's syndrome in 2 patients. Mean operating time was 96 minutes (range 80-135 mts). 3 Patients were converted to open cholecystectomy because of obscure anatomy, intraoperative hemorrhage and CBD injury. The Patient with CBD injury was managed by hepaticojejunostomy. 5 Patients developed postoperative biliary fistula and one Patient had prolonged ileus. Out of the 5 Patients 2 were managed with percutaneous drainage and the biliary leak stopped and 3 Patients required ERCP and stenting. The Patient with ileus was managed conservatively and was discharged on the 6th day. The average hospital stay was 4 days. Fundus first laparoscopic cholecystectomy offers the surgeon the same safety and versatility during laparoscopic cholecystectomy that it confers during open cholecystectomy. It is a viable and a safe option in the hands of an experienced laparoscopic surgeon and it helps in reducing the conversion rate and may also decrease the risk of injury to biliary system. [ABSTRACT FROM AUTHOR]

Published
2015

49. Acute Reversal of Warfarin Therapy in Patient with Protein C and S Deficiency Presenting for Emergency Surgery.

Author

Dash, Sananta kumar, Parikh, Harshel G., Tiwari, Saurabh B., and Kondwilkar, Bharti D.

Subjects
WARFARIN, PROTEIN C deficiency, PROTEIN S deficiency, AMPUTATION, FINGER surgery
Abstract

The article describes the case of a 19-year-old male diagnosed with protein C and protein S deficiency and posted for amputation fingers in emergency. Particular focus is given to the results of examination, liver and kidney function tests and Doppler study of right forearm. For reversal of warfarin therapy, fresh frozen plasma and vitamin K were used on the patient. It notes that anaesthesia was induced and maintained with oxygen nitrous oxide.

Published
2010

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