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1. International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4: Molecular Subtypes of Bladder Cancer—Principles of Classification and Emerging Clinical Utility

Author

Warrick, Joshua I., Al-Ahmadie, Hikmat, Berman, David M., Black, Peter C., Flaig, Thomas W., Höglund, Mattias, Bubendorf, Lukas, van der Kwast, Theodorus H., Cheng, Liang, Adeniran, Adebowale, Al-Ahimadie, Hikmat, Algaba, Fernando, Allory, Yves, Bhattarai, Selina, Black, Peter, Berman, David, Bertz, Simone, Bubendorf, Lukas, Carlsen, Birgitte, Carvalho, Rita, Cheng, Liang, Chijioke, Obinna, Cho, Yong Mee, Comperat, Eva, di Cunha, Isabela, Dagher, Julien, de Cunha, Isabella, Delahunt, Brett, Downes, Michelle, Flaig, Thomas, Fleischmann, Achim, Florescu, Cosmin, Fontugne, Jacqueline, Genitsch, Vera, Gløersen, Guro Horni, von Gunten, Michael, Grobholz, Rainer, HanselArndt Hartmann, Donna, Hernandez, Loren Herrera, Hogland, Mattias, Huang, Jiaoti, Jensen, Brad, Iczkowski, Kenneth, Jimenez, Rafael, Jovanovic, Bojana, Kamat, Ashish, Koellermann, Jens, Levin, Trevor, Liedberg, Fredrik, Lopez-Beltran, Antonio, Loya, Anand C, Lyngra, Marianne, McHale, Teresa, Mokeddem, Khadidja, Netto, George, Nourieh, Maya, O’Rourke, Declan, Ostahi, Irina-Alexandra, Paner, Gladell, Picken, Maria M, Pineda, Flavia Guzman, Raspollini, Camelia Radulescu Maria, Reis, Henning, Ruoyu, Shi, Samaratunga, Hemamali, Semba, Remi, Shah, Nigam, Shen, Steven, Smith, Steven, Smith, Tovia, Srigley, John, Suzigan, Sueli, Swarbrick, Nicole, Szalay, Ildiko, Talleraas, Inger, Tille, Jean-Christophe, Toma, Marieta, Trias, Isabel, Tsuzuki, Toyonori, van der Kwast, Theodorus, van Rhijn, Bas, Varma, Murali, Verbeke, Sofie, Verma, Sangeeta, Vlajnic, Tatjana, Vlatkovic, Ljiljana, Warren, Anne, Warrick, Joshua, Williamson, Sean, Wobker, Sara, Woods, Clifton, Yang, Chen, and Yoon, Ghilsuk

Published
2024
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3. Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients

Author

Fuchs, Talia L., Maclean, Fiona, Turchini, John, Vargas, A. Cristina, Bhattarai, Selina, Agaimy, Abbas, Hartmann, Arndt, Kao, Chia-Sui, Ellis, Carla, Bonert, Michael, Leroy, Xavier, Kunju, Lakshmi P., Schwartz, Lauren, Matsika, Admire, Williamson, Sean R., Rao, Priya, Divatia, Mukul, Guarch, Rosa, Algaba, Ferran, Balancin, Marcelo L., Zhou, Ming, Samaratunga, Hemamali, da Cunha, Isabela Werneck, Brimo, Fadi, Ryan, Andrew, Clouston, David, Aron, Manju, O’Donnell, Marie, Chan, Emily, Hirsch, Michelle S., Moch, Holger, Pang, Chun-Yin, Wah, Cheuk, Yin, Weihua, Perry-Keene, Joanna, Yilmaz, Asli, Chou, Angela, Clarkson, Adele, van der Westhuizen, Gerhard, Morrison, Ella, Zwi, Jonathan, Hes, Ondrej, Trpkov, Kiril, and Gill, Anthony J.

Published
2022
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4. International Society of Urological Pathology Consensus Conference on Current Issues in Bladder Cancer. Working Group 4: Molecular Subtypes of Bladder Cancer—Principles of Classification and Emerging Clinical Utility

Author

Warrick, Joshua I., Al-Ahmadie, Hikmat, Berman, David M., Black, Peter C., Flaig, Thomas W., Höglund, Mattias, Bubendorf, Lukas, van der Kwast, Theodorus H., Cheng, Liang, Adeniran, Adebowale, Al-Ahimadie, Hikmat, Algaba, Fernando, Allory, Yves, Bhattarai, Selina, Black, Peter, Berman, David, Bertz, Simone, Bubendorf, Lukas, Carlsen, Birgitte, Carvalho, Rita, Cheng, Liang, Chijioke, Obinna, Cho, Yong Mee, Comperat, Eva, di Cunha, Isabela, Dagher, Julien, de Cunha, Isabella, Delahunt, Brett, Downes, Michelle, Flaig, Thomas, Fleischmann, Achim, Florescu, Cosmin, Fontugne, Jacqueline, Genitsch, Vera, Gløersen, Guro Horni, von Gunten, Michael, Grobholz, Rainer, HanselArndt Hartmann, Donna, Hernandez, Loren Herrera, Hogland, Mattias, Huang, Jiaoti, Jensen, Brad, Iczkowski, Kenneth, Jimenez, Rafael, Jovanovic, Bojana, Kamat, Ashish, Koellermann, Jens, Levin, Trevor, Liedberg, Fredrik, Lopez-Beltran, Antonio, Loya, Anand C, Lyngra, Marianne, McHale, Teresa, Mokeddem, Khadidja, Netto, George, Nourieh, Maya, O’Rourke, Declan, Ostahi, Irina-Alexandra, Paner, Gladell, Picken, Maria M, Pineda, Flavia Guzman, Raspollini, Camelia Radulescu Maria, Reis, Henning, Ruoyu, Shi, Samaratunga, Hemamali, Semba, Remi, Shah, Nigam, Shen, Steven, Smith, Steven, Smith, Tovia, Srigley, John, Suzigan, Sueli, Swarbrick, Nicole, Szalay, Ildiko, Talleraas, Inger, Tille, Jean-Christophe, Toma, Marieta, Trias, Isabel, Tsuzuki, Toyonori, van der Kwast, Theodorus, van Rhijn, Bas, Varma, Murali, Verbeke, Sofie, Verma, Sangeeta, Vlajnic, Tatjana, Vlatkovic, Ljiljana, Warren, Anne, Warrick, Joshua, Williamson, Sean, Wobker, Sara, Woods, Clifton, Yang, Chen, and Yoon, Ghilsuk

Published
2023
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7. Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion

Author

Hornigold, Nick, Dunn, Karen R., Craven, Rachel A., Zougman, Alexandre, Trainor, Sebastian, Shreeve, Rebecca, Brown, Joanne, Sewell, Helen, Shires, Michael, Knowles, Margaret, Fukuwatari, Tsutomu, Maher, Eamonn R., Burns, Julie, Bhattarai, Selina, Menon, Mini, Brazma, Alvis, Scelo, Ghislaine, Feulner, Lara, Riazalhosseini, Yasser, Lathrop, Mark, Harris, Adrian, Selby, Peter J., Banks, Rosamonde E., and Vasudev, Naveen S.

Published
2020
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8. MRE11 as a Predictive Biomarker of Outcome After Radiation Therapy in Bladder Cancer

Author

Walker, Alexandra K., Karaszi, Katalin, Valentine, Helen, Strauss, Victoria Y., Choudhury, Ananya, McGill, Shaun, Wen, Kaisheng, Brown, Michael D., Ramani, Vijay, Bhattarai, Selina, Teo, Mark T.W., Yang, Lingjian, Myers, Kevin A., Deshmukh, Nayneeta, Denley, Helen, Browning, Lisa, Love, Sharon B., Iyer, Gopa, Clarke, Noel W., Hall, Emma, Huddart, Robert, James, Nicholas D., Hoskin, Peter J., West, Catharine M.L., and Kiltie, Anne E.

Published
2019
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9. The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Small Renal Cell Carcinomas after Image-Guided Cryoablation or Radio-Frequency Ablation

Author

Asif, Aqua, primary, Chan, Vinson Wai-Shun, additional, Osman, Filzah Hanis, additional, Koe, Jasmine Sze-Ern, additional, Ng, Alexander, additional, Burton, Oliver Edward, additional, Cartledge, Jon, additional, Kimuli, Michael, additional, Vasudev, Naveen, additional, Ralph, Christy, additional, Jagdev, Satinder, additional, Bhattarai, Selina, additional, Smith, Jonathan, additional, Lenton, James, additional, and Wah, Tze Min, additional

Published
2023
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10. Data from MRE11 Expression Is Predictive of Cause-Specific Survival following Radical Radiotherapy for Muscle-Invasive Bladder Cancer

Author

Choudhury, Ananya, primary, Nelson, Louisa D., primary, Teo, Mark T.W., primary, Chilka, Sameer, primary, Bhattarai, Selina, primary, Johnston, Colin F., primary, Elliott, Faye, primary, Lowery, Johanna, primary, Taylor, Claire F., primary, Churchman, Michael, primary, Bentley, Johanne, primary, Knowles, Margaret A., primary, Harnden, Patricia, primary, Bristow, Robert G., primary, Bishop, D. Timothy, primary, and Kiltie, Anne E., primary

Published
2023
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11. Supplementary Figures 1-2 from MRE11 Expression Is Predictive of Cause-Specific Survival following Radical Radiotherapy for Muscle-Invasive Bladder Cancer

Author

Choudhury, Ananya, primary, Nelson, Louisa D., primary, Teo, Mark T.W., primary, Chilka, Sameer, primary, Bhattarai, Selina, primary, Johnston, Colin F., primary, Elliott, Faye, primary, Lowery, Johanna, primary, Taylor, Claire F., primary, Churchman, Michael, primary, Bentley, Johanne, primary, Knowles, Margaret A., primary, Harnden, Patricia, primary, Bristow, Robert G., primary, Bishop, D. Timothy, primary, and Kiltie, Anne E., primary

Published
2023
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12. Radiotherapy for Prostate Cancer: is it ‘what you do’ or ‘the way that you do it’? A UK Perspective on Technique and Quality Assurance

Author

Bonnington, Sue, Bradshaw, Lynne, Cooper, Debbie, Elliott, Emma, Herbert, Pippa, Holding, Peter, Howson, Joanne, Jones, Mandy, Lennon, Teresa, Lyons, Norma, Moody, Hilary, Plumb, Claire, O'Sullivan, Tricia, Salter, Liz, Tidball, Sarah, Thompson, Pauline, Adam, Tonia, Askew, Sarah, Atkinson, Sharon, Baynes, Tim, Blaikie, Jan, Brain, Carole, Breen, Viv, Brunt, Sarah, Bryne, Sean, Bythem, Jo, Clarke, Jenny, Cloete, Jenny, Dark, Susan, Davis, Gill, De La Rue, Rachael, Denizot, Jane, Dewhurst, Elspeth, Dimes, Anna, Dixon, Nicola, Ebbs, Penny, Emmerson, Ingrid, Ferguson, Jill, Gadd, Ali, Geoghegan, Lisa, Grant, Alison, Grant, Collette, Gray, Catherine, Godfrey, Rosemary, Goodwin, Louise, Hall, Susie, Hart, Liz, Harvey, Andrew, Hoult, Chloe, Hawkins, Sarah, Holling, Sharon, Innes, Alastair, Kilner, Sue, Marshall, Fiona, Mellen, Louise, Moore, Andrea, Napier, Sally, Needham, Julie, Pearse, Kevin, Pisa, Anna, Rees, Mark, Richards, Elliw, Robson, Lindsay, Roxburgh, Janet, Samuel, Nikki, Sharkey, Irene, Slater, Michael, Smith, Donna, Taggart, Pippa, Taylor, Helen, Taylor, Vicky, Thomas, Ayesha, Tomkies, Briony, Trewick, Nicola, Ward, Claire, Walker, Christy, Williams, Ayesha, Woodhouse, Colin, Wyber, Elizabeth, Aning, Jonathan, Bollina, Prasad, Catto, Jim, Doble, Andrew, Doherty, Alan, Durkan, Garett, Gillatt, David, Hughes, Owen, Kocklebergh, Roger, Kouparis, Anthony, Kynaston, Howard, Leung, Hing, Mariappan, Param, McNeill, Alan, Paez, Edgar, Paul, Alan, Persad, Raj, Powell, Philip, Prescott, Stephen, Rosario, Derek, Rowe, Edward, Schwaibold, Hartwig, Tulloch, David, Wallace, Mike, Bahl, Amit, Benson, Richard, Beresford, Mark, Ferguson, Catherine, Graham, John, Herbert, Chris, Howard, Graham, James, Nick, Law, Alastair, Loughrey, Carmel, Mason, Malcolm, McClaren, Duncan, Patterson, Helen, Pedley, Ian, Robinson, Angus, Russell, Simon, Staffurth, John, Symonds, Paul, Thanvi, Narottam, Vasanthan, Subramaniam, Wilson, Paula, Appleby, Helen, Ash, Dominic, Aston, Dean, Bolton, Steven, Chalmers, Graham, Conway, John, Early, Nick, Geater, Tony, Goddall, Lynda, Heymann, Claire, Hicks, Deborah, Jones, Liza, Lamb, Susan, Lambert, Geoff, Lawrence, Gill, Lewis, Geraint, Lilley, John, MacLeod, Aileen, Massey, Pauline, McQueen, Alison, Moore, Rollo, Penketh, Lynda, Potterton, Janet, Roberts, Neil, Showler, Helen, Slade, Stephen, Steele, Alasdair, Swinscoe, James, Tiffany, Marie, Townley, John, Treeby, Jo, Wilkinson, Joyce, Williams, Lorraine, Wills, Lucy, Woodley, Owain, Yarrow, Sue, Bhattarai, Selina, Deshmukh, Neeta, Dormer, John, Fernando, Malee, Goepel, John, Griffiths, David, Grigor, Ken, Mayer, Nick, Oxley, Jon, Robinson, Mary, Varma, Murali, Warren, Anne, Brindle, Lucy, Davis, Michael, Dedman, Dan, Down, Elizabeth, Khazragui, Hanan, Metcalfe, Chris, Noble, Sian, Peters, Tim, Taylor, Hilary, Turner, Emma, Wade, Julia, Walsh, Eleanor, Baker, Susan, Bellis-Sheldon, Elizabeth, Bougard, Chantal, Bowtell, Joanne, Brewer, Catherine, Burton, Chris, Charlton, Jennie, Christoforou, Nicholas, Clark, Rebecca, Coull, Susan, Croker, Christine, Currer, Rosemary, Daisey, Claire, Delaney, Gill, Donohue, Rose, Drew, Jane, Farmer, Rebecca, Fry, Susan, Haddow, Jean, Hale, Alex, Halpin, Susan, Harris, Belle, Hattrick, Barbara, Holmes, Sharon, Hunt, Helen, Jackson, Vicky, Johnson, Donna, Le Butt, Mandy, Leworthy, Jo, Liddiatt, Tanya, Martin, Alex, Mauree, Jainee, Moore, Susan, Moulam, Gill, Mutch, Jackie, Parker, Kathleen, Pawsey, Christopher, Purdie, Michelle, Robson, Teresa, Smith, Lynne, Stenton, Carole, Steuart-Feilding, Tom, Sully, Chris, Sutton, Caroline, Torrington, Carol, Wilkins, Zoe, Williams, Sharon, Wilson, Andrea, Grant, Adrian, Roberts, Ian, Ashby, Deborah, Cowan, Richard, Fayers, Peter, Mellon, Killian, N'Dow, James, O'Brien, Tim, Sokhal, Michael, Baum, Michael, Adolfson, Jan, Albertsen, Peter, Dearnaley, David, Schroeder, Fritz, Roberts, Tracy, Zietman, Anthony, Mason, M.D., Moore, R., Jones, G., Lewis, G., Donovan, J.L., Neal, D.E., Hamdy, F.C., Lane, J.A., and Staffurth, J.N.

Published
2016
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15. MP50-04 MULTIMODAL IMAGE-GUIDED ABLATION ON MANAGEMENT OF RENAL CANCER IN VON-HIPPEL-LINDAU (VHL) SYNDROME PATIENTS FROM 2004 TO 2021 AT A SPECIALIST CENTRE: A LONGITUDINAL OBSERVATIONAL STUDY

Author

Wai-Shun Chan, Vinson, primary, Lenton, James, additional, Smith, Jonathan, additional, Jagdev, Satinder, additional, Ralph, Christy, additional, Vasudev, Naveen, additional, Bhattarai, Selina, additional, Lewington, Andrew, additional, Kimuli, Michael, additional, Cartledge, Jon, additional, and Wah, Tze Min, additional

Published
2022
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16. PD18-08 PROGNOSTIC VALUE OF NEUTROPHIL-TO-LYMPHOCYTE RATIO AND PLATELET-TO-LYMPHOCYTE RATIO FOR SMALL RENAL CELL CARCINOMAS AFTER IMAGE-GUIDED CRYOABLATION (CRYO) OR RADIO-FREQUENCY ABLATION (RFA)

Author

Asif, Aqua, primary, Osman, Filzah Hanis, additional, Sze-Ern Koe, Jasmine, additional, Ng, Alexander, additional, Cartledge, Jon, additional, Kimuli, Michael, additional, Vasudev, Naveen, additional, Ralph, Christy, additional, Jagdev, Satinder, additional, Bhattarai, Selina, additional, Smith, Jonathan, additional, Lenton, James, additional, Wai-Shun Chan, Vinson, additional, and Wah, Tze Min, additional

Published
2022
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17. MP42-02 PERCUTANEOUS IMAGE GUIDED CRYOABLATION AND RADIO-FREQUENCY ABLATION VERSUS PARTIAL NEPHRECTOMY FOR SMALL RENAL CELL CARCINOMAS: A TEN-YEARS, SINGLE CENTRE OBSERVATIONAL STUDY

Author

Wai-Shun Chan, Vinson, primary, Osman, Filzah, additional, Cartledge, Jon, additional, Kimuli, Michael, additional, Vasudev, Naveen, additional, Ralph, Christy, additional, Jagdev, Satinder, additional, Bhattarai, Selina, additional, Smith, Jonathan, additional, Lenton, James, additional, and Wah, Tze Min, additional

Published
2021
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21. Gleason drift in the NIHR ProtecT study

Author

Oxley, Jon, Simpkin, Andrew, Goepel, John, Varma, Murali, Griffiths, David, Grigor, Ken, Mayer, Nick, Warren, Anne, Deshmukh, Nayneeta, Bhattarai, Selina, Dormer, John, Hounsome, Luke, Adamczyk, Lukasz A, Metcalfe, Christopher, Lane, Athene J, Davis, Michael, Donovan, Jenny L, Neal, David E, Hamdy, Freddy C, and Robinson, Mary C

Published
2015
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23. Ten-year mortality, disease progression, and treatment-related side effects in men with localised prostate cancer from the ProtecT randomised controlled trial according to treatment received

Author

Neal, David E., Metcalfe, Chris, Donovan, Jenny L., Lane, J. Athene, Davis, Michael, Young, Grace J., Dutton, Susan J., Walsh, Eleanor I., Martin, Richard M., Peters, Tim. J., Turner, Emma L., Mason, Malcolm, Bryant, Richard, Bollina, Prasad, Catto, James, Doherty, Alan, Gillatt, David, Gnanapragasam, Vincent, Holding, Peter, Hughes, Owen, Kockelbergh, Roger, Kynaston, Howard, Oxley, Jon, Paul, Alan, Paez, Edgar, Rosario, Derek J., Rowe, Edward, Staffurth, John, Altman, Doug G., Hamdy, Freddie C., Peters, Tim J., Doble, Andrew, Powell, Philip, Prescott, Stephen, Rosario, Derek, Anderson, John B., Aning, Jonathan, Durkan, Garett, Koupparis, Anthony, Leung, Hing, Mariappan, Param, McNeill, Alan, Persad, Raj, Schwaibold, Hartwig, Tulloch, David, Wallace, Michael, Bonnington, Susan, Bradshaw, Lynne, Cooper, Deborah, Elliott, Emma, Herbert, Phillipa, Howson, Joanne, Jones, Amanda, Lennon, Teresa, Lyons, Norma, Moody, Hilary, Plumb, Claire, O'Sullivan, Tricia, Salter, Elizabeth, Thompson, Pauline, Tidball, Sarah, Blaikie, Jan, Gray, Catherine, Adam, Tonia, Askew, Sarah, Atkinson, Sharon, Baynes, Tim, Brain, Carole, Breen, Viv, Brunt, Sarah, Bryne, Sean, Bythem, Jo, Clarke, Jenny, Cloete, Jenny, Dark, Susan, Davis, Gill, Rue, Rachael De La, Denizot, Jane, Dewhurst, Elspeth, Dimes, Anna, Dixon, Nicola, Ebbs, Penny, Emmerson, Ingrid, Ferguson, Jill, Gadd, Ali, Geoghegan, Lisa, Grant, Alison, Grant, Collette, Godfrey, Rosemary, Goodwin, Louise, Hall, Susie, Hart, Liz, Harvey, Andrew, Hoult, Chloe, Hawkins, Sarah, Holling, Sharon, Innes, Alastair, Kilner, Sue, Marshall, Fiona, Mellen, Louise, Moore, Andrea, Napier, Sally, Needham, Julie, Pearse, Kevin, Pisa, Anna, Rees, Mark, Richards, Ellie, Robson, Lindsay, Roxburgh, Janet, Samuel, Nikki, Sharkey, Irene, Slater, Michael, Smith, Donna, Taggart, Pippa, Taylor, Helen, Taylor, Vicky, Thomas, Ayesha, Tomkies, Briony, Trewick, Nicola, Ward, Claire, Walker, Christy, Williams, Ayesha, Woodhouse, Colin, Wyber, Elizabeth, Bahl, Amit, Benson, Richard, Beresford, Mark, Ferguson, Catherine, Graham, John, Herbert, Chris, Howard, Grahame, James, Nick, Kirkbride, Peter, Law, Alastair, Loughrey, Carmel, McClaren, Duncan, Patterson, Helen, Pedley, Ian, Roberts, Trevor, Robinson, Angus, Russell, Simon, Symonds, Paul, Thanvi, Narottam, Vasanthan, Subramaniam, Wilson, Paula, Robinson, Mary, Bhattarai, Selina, Deshmukh, Neeta, Dormer, John, Fernando, Malee, Goepel, John, Griffiths, David, Grigor, Ken, Mayer, Nick, Varma, Murali, Warren, Anne, Appleby, Helen, Ash, Dominic, Aston, Dean, Bolton, Steven, Chalmers, Graham, Conway, John, Early, Nick, Geater, Tony, Goddall, Lynda, Heymann, Claire, Hicks, Deborah, Jones, Liza, Lamb, Susan, Lambert, Geoff, Lawrence, Gill, Lewis, Geraint, Lilley, John, MacLeod, Aileen, Massey, Pauline, McQueen, Alison, Moore, Rollo, Penketh, Lynda, Potterton, Janet, Roberts, Neil, Showler, Helen, Shuttleworth, Pam, Slade, Stephen, Steele, Alasdair, Swinscoe, James, Tiffany, Marie, Townley, John, Treeby, Jo, Weston, Michael, Wilkinson, Joyce, Williams, Lorraine, Wills, Lucy, Woodley, Owain, Yarrow, Sue, Brindle, Lucy, Davies, Linda, Dedman, Dan, Down, Elizabeth, Khazragui, Hanan, Noble, Sian, Taylor, Hilary, Tazewell, Marta, Wade, Julia, Walsh, Eleanor, Baker, Susan, Bellis-Sheldon, Elizabeth, Bougard, Chantal, Bowtell, Joanne, Brewer, Catherine, Burton, Chris, Charlton, Jennie, Christoforou, Nicholas, Clark, Rebecca, Coull, Susan, Croker, Christine, Currer, Rosemary, Daisey, Claire, Delaney, Gill, Donohue, Rose, Drew, Jane, Farmer, Rebecca, Fry, Susan, Haddow, Jean, Hale, Alex, Halpin, Susan, Harris, Belle, Hattrick, Barbara, Holmes, Sharon, Hunt, Helen, Jackson, Vicky, Johnson, Donna, Le Butt, Mandy, Leworthy, Jo, Liddiatt, Tanya, Martin, Alex, Mauree, Jainee, Moore, Susan, Moulam, Gill, Mutch, Jackie, Parker, Kathleen, Pawsey, Christopher, Purdie, Michelle, Robson, Teresa, Smith, Lynne, Stenton, Carole, Steuart-Feilding, Tom, Stott, Beth, Sully, Chris, Sutton, Caroline, Torrington, Carol, Wilkins, Zoe, Williams, Sharon, Wilson, Andrea, Weaver, Ashleigh, Albertsen, Peter, Adolfsson, Jan, Baum, Michael, McFarlane, Jon, Reid, Colette, Turner, Emma, Zietman, Anthony, Hill, Elizabeth, Ng, Siaw Yein, Williams, Naomi, Toole, Jessica, Davies, Charlotte, Hughes, Laura, Rowlands, Mari-Anne, Bell, Lindsey, Harrison, Sean, Mauree, Jainnee, Grant, Adrian, Roberts, Ian, Ashby, Deborah, Cowan, Richard, Fayers, Peter, Mellon, Killian, N’Dow, James, O’Brien, Tim, Sokhal, Michael, Dearnaley, David, Schröder, Fritz, Roberts, Tracy, and for the ProtecT Study Group, .

Subjects
Male, medicine.medical_specialty, Time Factors, Urology, medicine.medical_treatment, 030232 urology & nephrology, Urinary incontinence, Active monitoring, BTC (Bristol Trials Centre), Metastasis, law.invention, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, ProtecT trial, Randomized controlled trial, law, Internal medicine, Humans, Medicine, External beam radiotherapy, Watchful Waiting, Aged, Prostatectomy, Disease progression, Radiotherapy, business.industry, Prostatic Neoplasms, Middle Aged, medicine.disease, Radical prostatectomy, Treatment Outcome, 030220 oncology & carcinogenesis, Propensity score matching, Cohort, Disease Progression, BRTC, medicine.symptom, Sexual function, business, Literatur Kommentiert
Abstract

Background: The ProtecT trial reported intention-to-treat analysis of men with localised prostate cancer (PCa) randomly allocated to active monitoring (AM), radical prostatectomy, and external beam radiotherapy. Objective: To determine report outcomes according to treatment received in men in randomised and treatment choice cohorts. Design, Setting, and Participants: This study focuses on secondary care. Men with clinically localised prostate cancer at one of nine UK centres were invited to participate in the treatment trial comparing AM, radical prostatectomy, and radiotherapy. Intervention: Two cohorts included 1643 men who agreed to be randomised; 997 declined randomisation and chose treatment. Outcome Measurements and Statistical Analysis: Health-related quality of life impacts on urinary, bowel, and sexual function were assessed using patient-reported outcome measures. Analysis was carried out based on treatment received for each cohort and on pooled estimates using meta-analysis. Differences were estimated with adjustment for known prognostic factors using propensity scores. Results and Limitations: According to treatment received, more men receiving AM died of PCa (AM 1.85%, surgery 0.67%, radiotherapy 0.73%), whilst this difference remained consistent with chance in the randomised cohort (p = 0.08); stronger evidence was found in the exploratory analyses (randomised plus choice cohort) when AM was compared with the combined radical treatment group (p = 0.003). There was also strong evidence that metastasis (AM 5.6%, surgery 2.4%, radiotherapy 2.7%) and disease progression (AM 20.35%, surgery 5.87%, radiotherapy 6.62%) were more common in the AM group. Compared with AM, there were higher risks of sexual dysfunction (95% at 6 mo) and urinary incontinence (55% at 6 mo) after surgery, and of sexual dysfunction (88% at 6 mo) and bowel dysfunction (5% at 6 mo) after radiotherapy. The key limitations are the potential for bias when comparing groups defined by treatment received and outdating of the interventions being evaluated during the lengthy follow-up required in trials of screen-detected PCa. Conclusions: Analyses according to treatment received showed increased rates of disease-related events and lower rates of patient-reported harms in men managed by AM compared with men managed by radical treatment, and stronger evidence of greater PCa mortality in the AM group. Patient Summary: More than 90 out of every 100 men with localised prostate cancer do not die of prostate cancer within 10 yr, irrespective of whether treatment is by means of monitoring, surgery, or radiotherapy. Side effects on sexual and bladder function are much better after active monitoring, but the risks of spreading of prostate cancer are more common.

Published
2020

24. Urinothorax following percutaneous image-guided renal cryoablation

Author

Ng, Helen, primary, Wang, Kaiwen, additional, Cartledge, Jon, additional, Biyani, Chandra Shekhar, additional, Ralph, Christy, additional, Jagdev, Satinder, additional, Vasudev, Naveen, additional, Bhattarai, Selina, additional, Bhartia, Bobby,, additional, Lenton, James, additional, Smith, Jonathan, additional, Whiteley, Simon, additional, Tcherveniakov, Peter, additional, and Wah, Tze Min, additional

Published
2020
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25. UK Multicenter Prospective Evaluation of the Leibovich Score in Localized Renal Cell Carcinoma: Performance has Altered Over Time

Author

Vasudev, Naveen S., primary, Hutchinson, Michelle, additional, Trainor, Sebastian, additional, Ferguson, Roisean, additional, Bhattarai, Selina, additional, Adeyoju, Adebanji, additional, Cartledge, Jon, additional, Kimuli, Michael, additional, Datta, Shibendra, additional, Hanbury, Damian, additional, Hrouda, David, additional, Oades, Grenville, additional, Patel, Poulam, additional, Soomro, Naeem, additional, Stewart, Grant D., additional, Sullivan, Mark, additional, Webster, Jeff, additional, Messenger, Michael, additional, Selby, Peter J., additional, and Banks, Rosamonde E., additional

Published
2020
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27. Patient-reported outcomes in the ProtecT randomized trial of clinically localized prostate cancer treatments: study design, and baseline urinary, bowel and sexual function and quality of life

Author

Lane, Athene, Metcalfe, Chris, Young, Grace J., Peters, Tim J., Blazeby, Jane, Avery, Kerry N. L., Dedman, Daniel, Down, Liz, Mason, Malcolm D., Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Bonnington, Sue, Bradshaw, Lynne, Cooper, Debbie, Elliott, Emma, Herbert, Pippa, Holding, Peter, Howson, Joanne, Jones, Mandy, Lennon, Teresa, Lyons, Norma, Moody, Hilary, Plumb, Claire, O'Sullivan, Tricia, Salter, Liz, Tidball, Sarah, Thompson, Pauline, Adam, Tonia, Askew, Sarah, Atkinson, Sharon, Baynes, Tim, Blaikie, Jan, Brain, Carole, Breen, Viv, Brunt, Sarah, Bryne, Sean, Bythem, Jo, Clarke, Jenny, Cloete, Jenny, Dark, Susan, Davis, Gill, De La Rue, Rachael, Denizot, Jane, Dewhurst, Elspeth, Dimes, Anna, Dixon, Nicola, Ebbs, Penny, Emmerson, Ingrid, Ferguson, Jill, Gadd, Ali, Geoghegan, Lisa, Grant, Alison, Grant, Collette, Gray, Catherine, Godfrey, Rosemary, Goodwin, Louise, Hall, Susie, Hart, Liz, Harvey, Andrew, Hoult, Chloe, Hawkins, Sarah, Holling, Sharon, Innes, Alastair, Kilner, Sue, Marshall, Fiona, Mellen, Louise, Moore, Andrea, Napier, Sally, Needham, Julie, Pearse, Kevin, Pisa, Anna, Rees, Mark, Richards, Elliw, Robson, Lindsay, Roxburgh, Janet, Samuel, Nikki, Sharkey, Irene, Slater, Michael, Smith, Donna, Taggart, Pippa, Taylor, Helen, Taylor, Vicky, Thomas, Ayesha, Tomkies, Briony, Trewick, Nicola, Ward, Claire, Walker, Christy, Williams, Ayesha, Woodhouse, Colin, Wyber, Elizabeth, Aning, Jonathan, Bollina, Prasad, Catto, Jim, Doble, Andrew, Doherty, Alan, Durkan, Garett, Gillatt, David, Hughes, Owen, Kocklebergh, Roger, Kouparis, Anthony, Kynaston, Howard, Leung, Hing, Mariappan, Param, McNeill, Alan, Paez, Edgar, Paul, Alan, Persad, Raj, Powell, Philip, Prescott, Stephen, Rosario, Derek, Rowe, Edward, Schwaibold, Hartwig, Tulloch, David, Wallace, Mike, Bahl, Amit, Benson, Richard, Beresford, Mark, Ferguson, Catherine, Graham, John, Herbert, Chris, Howard, Grahame, James, Nick, Law, Alastair, Loughrey, Carmel, McClaren, Duncan, Patterson, Helen, Pedley, Ian, Robinson, Angus, Russell, Simon, Staffurth, John, Symonds, Paul, Thanvi, Narottam, Vasanthan, Subramaniam, Wilson, Paula, Appleby, Helen, Ash, Dominic, Aston, Dean, Bolton, Steven, Chalmers, Graham, Conway, John, Early, Nick, Geater, Tony, Goddall, Lynda, Heymann, Claire, Hicks, Deborah, Jones, Liza, Lamb, Susan, Lambert, Geoff, Lawrence, Gill, Lewis, Geraint, Lilley, John, MacLeod, Aileen, Massey, Pauline, McQueen, Alison, Moore, Rollo, Penketh, Lynda, Potterton, Janet, Roberts, Neil, Showler, Helen, Slade, Stephen, Steele, Alasdair, Swinscoe, James, Tiffany, Marie, Townley, John, Treeby, Jo, Wilkinson, Joyce, Williams, Lorraine, Wills, Lucy, Woodley, Owain, Yarrow, Sue, Bhattarai, Selina, Deshmukh, Neeta, Dormer, John, Fernando, Malee, Goepel, John, Griffiths, David, Grigor, Ken, Mayer, Nick, Oxley, Jon, Robinson, Mary, Varma, Murali, Warren, Anne, Brindle, Lucy, Davis, Michael, Khazragui, Hanan, Noble, Sian, Taylor, Hilary, Tazewell, Marta, Turner, Emma, Wade, Julia, Walsh, Eleanor, Baker, Susan, Bellis‐Sheldon, Elizabeth, Bougard, Chantal, Bowtell, Joanne, Brewer, Catherine, Burton, Chris, Charlton, Jennie, Christoforou, Nicholas, Clark, Rebecca, Coull, Susan, Croker, Christine, Currer, Rosemary, Daisey, Claire, Delaney, Gill, Donohue, Rose, Drew, Jane, Farmer, Rebecca, Fry, Susan, Haddow, Jean, Hale, Alex, Halpin, Susan, Harris, Belle, Hattrick, Barbara, Holmes, Sharon, Hunt, Helen, Jackson, Vicky, Johnson, Donna, Le Butt, Mandy, Leworthy, Jo, Liddiatt, Tanya, Martin, Alex, Mauree, Jainee, Moore, Susan, Moulam, Gill, Mutch, Jackie, Nash, Alena, Parker, Kathleen, Pawsey, Christopher, Purdie, Michelle, Robson, Teresa, Smith, Lynne, Snoeck, Jo, Stenton, Carole, Steuart‐Feilding, Tom, Sully, Chris, Sutton, Caroline, Torrington, Carol, Wilkins, Zoe, Williams, Sharon, Wilson, Andrea, Grant, Adrian, Roberts, Ian, Ashby, Deborah, Cowan, Richard, Fayers, Peter, Mellon, Killian, N'Dow, James, O'Brien, Tim, Sokhal, Michael, Baum, Michael, Adolfson, Jan, Albertsen, Peter, Dearnaley, David, Schroeder, Fritz, Roberts, Tracy, and Zietman, Anthony

Subjects
Male, Urological Oncology, functional status, law.invention, Prostate cancer, 0302 clinical medicine, Randomized controlled trial, Quality of life, law, 030212 general & internal medicine, media_common, treatment, Middle Aged, Urology & Nephrology, prostate cancer, Treatment Outcome, Centre for Surgical Research, 030220 oncology & carcinogenesis, Functional status, BRTC, Sexuality, medicine.medical_specialty, Urology, Urinary system, media_common.quotation_subject, Urination, Social class, BTC (Bristol Trials Centre), 03 medical and health sciences, ProtecT trial, Digestive System Physiological Phenomena, Internal medicine, medicine, Humans, Patient Reported Outcome Measures, Aged, business.industry, Prostatic Neoplasms, 1103 Clinical Sciences, protect trial, medicine.disease, Treatment, ISRCTN 20141297, Physical therapy, Quality of Life, Sexual function, business
Abstract

Objectives To present the baseline patient-reported outcome measures (PROMs) in the Prostate Testing for Cancer and Treatment (ProtecT) randomized trial comparing active monitoring, radical prostatectomy and external-beam conformal radiotherapy for localized prostate cancer and to compare results with other populations. Materials and Methods A total of 1643 randomized men, aged 50–69 years and diagnosed with clinically localized disease identified by prostate-specific antigen (PSA) testing, in nine UK cities in the period 1999–2009 were included. Validated PROMs for disease-specific (urinary, bowel and sexual function) and condition-specific impact on quality of life (Expanded Prostate Index Composite [EPIC], 2005 onwards; International Consultation on Incontinence Questionnaire- Urinary Incontinence [ICIQ-UI], 2001 onwards; the International Continence Society short-form male survey [ICSmaleSF]; anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), generic mental and physical health (12-item short-form health survey [SF-12]; EuroQol quality-of-life survey, the EQ-5D-3L) were assessed at prostate biopsy clinics before randomization. Descriptive statistics are presented by treatment allocation and by men’s age at biopsy and PSA testing time points for selected measures. Results A total of 1438 participants completed biopsy questionnaires (88%) and 77–88% of these were analysed for individual PROMs. Fewer than 1% of participants were using pads daily (5/ 754). Storage lower urinary tract symptoms were frequent (e.g. nocturia 22%, 312/1423). Bowel symptoms were rare, except for loose stools (16%, 118/754). One third of participants reported erectile dysfunction (241/735) and for 16% (118/731) this was a moderate or large problem. Depression was infrequent (80/1399, 6%) but 20% of participants (278/1403) reported anxiety. Sexual function and bother were markedly worse in older men (65– 70 years), whilst urinary bother and physical health were somewhat worse than in younger men (49–54 years, all P < 0.001). Bowel health, urinary function and depression were unaltered by age, whilst mental health and anxiety were better in older men (P < 0.001). Only minor differences existed in mental or physical health, anxiety and depression between PSA testing and biopsy assessments. Conclusion The ProtecT trial baseline PROMs response rates were high. Symptom frequencies and generic quality of life were similar to those observed in populations screened for prostate cancer and control subjects without cancer.

Published
2016

28. The ProtecT trial: analysis of the patient cohort, baseline risk stratification and disease progression.

Author

Bryant, Richard J., Oxley, Jon, Young, Grace J., Lane, Janet A., Metcalfe, Chris, Davis, Michael, Turner, Emma L., Martin, Richard M., Goepel, John R., Varma, Murali, Griffiths, David F., Grigor, Ken, Mayer, Nick, Warren, Anne Y., Bhattarai, Selina, Dormer, John, Mason, Malcolm, Staffurth, John, Walsh, Eleanor, and Rosario, Derek J.

Subjects
DISEASE progression, PROPORTIONAL hazards models, COHORT analysis
Abstract

Objective: To test the hypothesis that the baseline clinico‐pathological features of the men with localized prostate cancer (PCa) included in the ProtecT (Prostate Testing for Cancer and Treatment) trial who progressed (n = 198) at a 10‐year median follow‐up were different from those of men with stable disease (n = 1409). Patients and Methods: We stratified the study participants at baseline according to risk of progression using clinical disease stage, pathological grade and PSA level, using Cox proportional hazard models. Results: The findings showed that 34% of participants (n = 505) had intermediate‐ or high‐risk PCa, and 66% (n = 973) had low‐risk PCa. Of 198 participants who progressed, 101 (51%) had baseline International Society of Urological Pathology Grade Group 1, 59 (30%) Grade Group 2, and 38 (19%) Grade Group 3 PCa, compared with 79%, 17% and 5%, respectively, for 1409 participants without progression (P < 0.001). In participants with progression, 38% and 62% had baseline low‐ and intermediate‐/high‐risk disease, compared with 69% and 31% of participants with stable disease (P < 0.001). Treatment received, age (65–69 vs 50–64 years), PSA level, Grade Group, clinical stage, risk group, number of positive cores, tumour length and perineural invasion were associated with time to progression (P ≤ 0.005). Men progressing after surgery (n = 19) were more likely to have a higher Grade Group and pathological stage at surgery, larger tumours, lymph node involvement and positive margins. Conclusions: We demonstrate that one‐third of the ProtecT cohort consists of people with intermediate‐/high‐risk disease, and the outcomes data at an average of 10 years' follow‐up are generalizable beyond men with low‐risk PCa. [ABSTRACT FROM AUTHOR]

Published
2020
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29. Radiotherapy for Prostate Cancer: is it ‘what you do’ or ‘the way that you do it’? A UK Perspective on Technique and Quality Assurance

Author

Mason, M.D., primary, Moore, R., additional, Jones, G., additional, Lewis, G., additional, Donovan, J.L., additional, Neal, D.E., additional, Hamdy, F.C., additional, Lane, J.A., additional, Staffurth, J.N., additional, Bonnington, Sue, additional, Bradshaw, Lynne, additional, Cooper, Debbie, additional, Elliott, Emma, additional, Herbert, Pippa, additional, Holding, Peter, additional, Howson, Joanne, additional, Jones, Mandy, additional, Lennon, Teresa, additional, Lyons, Norma, additional, Moody, Hilary, additional, Plumb, Claire, additional, O'Sullivan, Tricia, additional, Salter, Liz, additional, Tidball, Sarah, additional, Thompson, Pauline, additional, Adam, Tonia, additional, Askew, Sarah, additional, Atkinson, Sharon, additional, Baynes, Tim, additional, Blaikie, Jan, additional, Brain, Carole, additional, Breen, Viv, additional, Brunt, Sarah, additional, Bryne, Sean, additional, Bythem, Jo, additional, Clarke, Jenny, additional, Cloete, Jenny, additional, Dark, Susan, additional, Davis, Gill, additional, De La Rue, Rachael, additional, Denizot, Jane, additional, Dewhurst, Elspeth, additional, Dimes, Anna, additional, Dixon, Nicola, additional, Ebbs, Penny, additional, Emmerson, Ingrid, additional, Ferguson, Jill, additional, Gadd, Ali, additional, Geoghegan, Lisa, additional, Grant, Alison, additional, Grant, Collette, additional, Gray, Catherine, additional, Godfrey, Rosemary, additional, Goodwin, Louise, additional, Hall, Susie, additional, Hart, Liz, additional, Harvey, Andrew, additional, Hoult, Chloe, additional, Hawkins, Sarah, additional, Holling, Sharon, additional, Innes, Alastair, additional, Kilner, Sue, additional, Marshall, Fiona, additional, Mellen, Louise, additional, Moore, Andrea, additional, Napier, Sally, additional, Needham, Julie, additional, Pearse, Kevin, additional, Pisa, Anna, additional, Rees, Mark, additional, Richards, Elliw, additional, Robson, Lindsay, additional, Roxburgh, Janet, additional, Samuel, Nikki, additional, Sharkey, Irene, additional, Slater, Michael, additional, Smith, Donna, additional, Taggart, Pippa, additional, Taylor, Helen, additional, Taylor, Vicky, additional, Thomas, Ayesha, additional, Tomkies, Briony, additional, Trewick, Nicola, additional, Ward, Claire, additional, Walker, Christy, additional, Williams, Ayesha, additional, Woodhouse, Colin, additional, Wyber, Elizabeth, additional, Aning, Jonathan, additional, Bollina, Prasad, additional, Catto, Jim, additional, Doble, Andrew, additional, Doherty, Alan, additional, Durkan, Garett, additional, Gillatt, David, additional, Hughes, Owen, additional, Kocklebergh, Roger, additional, Kouparis, Anthony, additional, Kynaston, Howard, additional, Leung, Hing, additional, Mariappan, Param, additional, McNeill, Alan, additional, Paez, Edgar, additional, Paul, Alan, additional, Persad, Raj, additional, Powell, Philip, additional, Prescott, Stephen, additional, Rosario, Derek, additional, Rowe, Edward, additional, Schwaibold, Hartwig, additional, Tulloch, David, additional, Wallace, Mike, additional, Bahl, Amit, additional, Benson, Richard, additional, Beresford, Mark, additional, Ferguson, Catherine, additional, Graham, John, additional, Herbert, Chris, additional, Howard, Graham, additional, James, Nick, additional, Law, Alastair, additional, Loughrey, Carmel, additional, Mason, Malcolm, additional, McClaren, Duncan, additional, Patterson, Helen, additional, Pedley, Ian, additional, Robinson, Angus, additional, Russell, Simon, additional, Staffurth, John, additional, Symonds, Paul, additional, Thanvi, Narottam, additional, Vasanthan, Subramaniam, additional, Wilson, Paula, additional, Appleby, Helen, additional, Ash, Dominic, additional, Aston, Dean, additional, Bolton, Steven, additional, Chalmers, Graham, additional, Conway, John, additional, Early, Nick, additional, Geater, Tony, additional, Goddall, Lynda, additional, Heymann, Claire, additional, Hicks, Deborah, additional, Jones, Liza, additional, Lamb, Susan, additional, Lambert, Geoff, additional, Lawrence, Gill, additional, Lewis, Geraint, additional, Lilley, John, additional, MacLeod, Aileen, additional, Massey, Pauline, additional, McQueen, Alison, additional, Moore, Rollo, additional, Penketh, Lynda, additional, Potterton, Janet, additional, Roberts, Neil, additional, Showler, Helen, additional, Slade, Stephen, additional, Steele, Alasdair, additional, Swinscoe, James, additional, Tiffany, Marie, additional, Townley, John, additional, Treeby, Jo, additional, Wilkinson, Joyce, additional, Williams, Lorraine, additional, Wills, Lucy, additional, Woodley, Owain, additional, Yarrow, Sue, additional, Bhattarai, Selina, additional, Deshmukh, Neeta, additional, Dormer, John, additional, Fernando, Malee, additional, Goepel, John, additional, Griffiths, David, additional, Grigor, Ken, additional, Mayer, Nick, additional, Oxley, Jon, additional, Robinson, Mary, additional, Varma, Murali, additional, Warren, Anne, additional, Brindle, Lucy, additional, Davis, Michael, additional, Dedman, Dan, additional, Down, Elizabeth, additional, Khazragui, Hanan, additional, Metcalfe, Chris, additional, Noble, Sian, additional, Peters, Tim, additional, Taylor, Hilary, additional, Turner, Emma, additional, Wade, Julia, additional, Walsh, Eleanor, additional, Baker, Susan, additional, Bellis-Sheldon, Elizabeth, additional, Bougard, Chantal, additional, Bowtell, Joanne, additional, Brewer, Catherine, additional, Burton, Chris, additional, Charlton, Jennie, additional, Christoforou, Nicholas, additional, Clark, Rebecca, additional, Coull, Susan, additional, Croker, Christine, additional, Currer, Rosemary, additional, Daisey, Claire, additional, Delaney, Gill, additional, Donohue, Rose, additional, Drew, Jane, additional, Farmer, Rebecca, additional, Fry, Susan, additional, Haddow, Jean, additional, Hale, Alex, additional, Halpin, Susan, additional, Harris, Belle, additional, Hattrick, Barbara, additional, Holmes, Sharon, additional, Hunt, Helen, additional, Jackson, Vicky, additional, Johnson, Donna, additional, Le Butt, Mandy, additional, Leworthy, Jo, additional, Liddiatt, Tanya, additional, Martin, Alex, additional, Mauree, Jainee, additional, Moore, Susan, additional, Moulam, Gill, additional, Mutch, Jackie, additional, Parker, Kathleen, additional, Pawsey, Christopher, additional, Purdie, Michelle, additional, Robson, Teresa, additional, Smith, Lynne, additional, Stenton, Carole, additional, Steuart-Feilding, Tom, additional, Sully, Chris, additional, Sutton, Caroline, additional, Torrington, Carol, additional, Wilkins, Zoe, additional, Williams, Sharon, additional, Wilson, Andrea, additional, Grant, Adrian, additional, Roberts, Ian, additional, Ashby, Deborah, additional, Cowan, Richard, additional, Fayers, Peter, additional, Mellon, Killian, additional, N'Dow, James, additional, O'Brien, Tim, additional, Sokhal, Michael, additional, Baum, Michael, additional, Adolfson, Jan, additional, Albertsen, Peter, additional, Dearnaley, David, additional, Schroeder, Fritz, additional, Roberts, Tracy, additional, and Zietman, Anthony, additional

Published
2016
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37. MRE11 Expression Is Predictive of Cause-Specific Survival following Radical Radiotherapy for Muscle-Invasive Bladder Cancer

Author

Choudhury, Ananya, primary, Nelson, Louisa D., additional, Teo, Mark T.W., additional, Chilka, Sameer, additional, Bhattarai, Selina, additional, Johnston, Colin F., additional, Elliott, Faye, additional, Lowery, Johanna, additional, Taylor, Claire F., additional, Churchman, Michael, additional, Bentley, Johanne, additional, Knowles, Margaret A., additional, Harnden, Patricia, additional, Bristow, Robert G., additional, Bishop, D. Timothy, additional, and Kiltie, Anne E., additional

Published
2010
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38. Gleason drift in the NIHR Protec T study.

Author

Oxley, Jon, Simpkin, Andrew, Goepel, John, Varma, Murali, Griffiths, David, Grigor, Ken, Mayer, Nick, Warren, Anne, Deshmukh, Nayneeta, Bhattarai, Selina, Dormer, John, Hounsome, Luke, Adamczyk, Lukasz A, Metcalfe, Christopher, Lane, J Athene, Davis, Michael, Donovan, Jenny L, Neal, David E, Hamdy, Freddy C, and Robinson, Mary C

Subjects
GLEASON grading system, PROSTATE cancer treatment, BIOPSY, PROSTATE-specific antigen, PROSTATECTOMY
Abstract

Aims There is increasing evidence of Gleason score ( GS) drift in prostatic core biopsies during the last two decades. The Protec T study is a randomized controlled study and provides an excellent cohort to study the effect of time, prostate-specific antigen ( PSA) level, perineural invasion, tumour length and age on GS. Methods and results The Protec T study recruited men in the United Kingdom between 1999 and 2010. The Gleason scores were grouped into four categories ≤3 + 3, 3 + 4, 4 + 3 and ≥4 + 4 for analysis. Data from England between 2000 and 2012 were also available. A total of 3282 biopsies containing cancer were analysed. For each year of the ProtecT study, the odds of being diagnosed with a higher GS category increased by 4.9%. Higher GS was also associated with perineural invasion, increasing tumour length, age and PSA level. While biopsy GS from England was incomplete, it also showed a marked decrease in GS five and six tumours during the same period. Conclusion There was GS drift from 3 + 3 to 3 + 4 with time in the ProtecT study, but there appeared to be no significant change in percentage of GS 4 + 3 or higher. This drift was less dramatic when compared to GS in the rest of England. [ABSTRACT FROM AUTHOR]

Published
2015
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41. Expanding the Clinicopathological Spectrum of Succinate Dehydrogenase-Deficient Renal Cell Carcinoma: 42 Novel Tumors in 38 Patients

Author

Maclean, Fiona, Mckenney, Jesse, Hes, Ondrej, Kao, Chia-Sui, Ellis, Carla L., Turchini, John, Samaratunga, Hemamali, Jonathan, Zwi, Bhattarai, Selina, Ryan, Andrew, Bonert, Michael, Leroy, Xavier, Kunju, L. Priya, Schwartz, Lauren, Williamson, Sean R., Matsika, Admire, Rao, Priya, Divatia, Mukul, Guarch, Rosa, Algaba, Ferran, Brimo, Fadi, Agaimy, Abbas, Marcelo Balancin, Da Cunha, Isabela W., Zhou, Ming, Trpkov, Kiril, and Gill, Anthony J.

42. Leiomyosarcoma of the spermatic cord: case report and literature review.

Author

Dangle P, Basavaraj DR, Bhattarai S, Paul AB, and Biyani CS

Abstract

A 51-year-old man presented with a 2-year history of painless lump in the left hemiscrotum. Scrotal examination demonstrated a 3-cm, firm-to-hard mass attached to the left spermatic cord. Scrotal ultrasound scan revealed a heterogeneous mass separate from the left testis and epididymis. An orchidectomy was recommended to the patient; however, he declined surgery and underwent excision biopsy of the lesion with preservation of the left testis. Histology suggested a leiomyosarcoma of the spermatic cord and positive margins. Following a normal staging CT scan, the patient was referred to the regional sarcoma clinic. He was treated with an orchidectomy. Microscopic examinations showed fibrosis in the spermatic cord and negative margins. The patient has been followed up for 12 months with CT scans and shows no signs of recurrence.

Published
2007

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