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772 results on '"Bi, Xue"'

17. A novel trifluoromethyl quinoline derivative targeting SGK1 inducing autophagy and apoptosis via regulating mTOR/FOXO3a pathway in glioblastoma

Author

Yu-feng Xiong, Cheng Li, Jia Yu, Xiaozhong Chen, Sha Cheng, Xin-yu Liu, Bi-xue Xu, Xiao Hu, Guang-can Xu, and Heng Luo

Subjects
Quinoline Derivative, Glioblastoma multiforme, Autophagy, SGK1, FOXO3a/mTOR signaling pathway, Chemistry, QD1-999
Abstract

Glioblastoma (GBM) is known for its aggressive nature and poor prognosis, with currently no effective treatment available. Research has shown that introducing fluorinated functional groups into different parts of natural product quinoline significantly affects its anti-tumor activity. Therefore, this study synthesized the trifluoromethyl quinoline derivative FKL296 to investigate its anti-tumor effect on GBM and reveal its mechanism of action. In vitro and in vivo studies have shown that FKL296 effectively inhibitd the growth of GBM and is relatively safe and low toxicity, whice also induced cell apoptosis and autophagy. Additionally, protein kinase profiling and molecular docking analyses have revealed a strong binding affinity between FKL296 and SGK1. Cellular thermal shift assay experiments have confirmed the targeting of SGK1 by FKL296 and its role in enhancing SGK1 stability. Bioinformatics analysis and pathway validation indicated that FKL296 targeted SGK1 and inhibited autophagy in tumor cells through the mTOR/FOXO3a signaling pathway. In summary, FKL296 may become a promising drug for the treatment of GBM.

Published
2024
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40. Quantum simulation of photosynthetic energy transfer

Author

Wang, Bi-Xue, Tao, Ming-Jie, Ai, Qing, Xin, Tao, Lambert, Neill, Ruan, Dong, Cheng, Yuan-Chung, Nori, Franco, Deng, Fu-Guo, and Long, Gui-Lu

Subjects
Quantum Physics, Physics - Biological Physics, Physics - Chemical Physics, Physics - Optics
Abstract

Near-unity energy transfer efficiency has been widely observed in natural photosynthetic complexes. This phenomenon has attracted broad interest from different fields, such as physics, biology, chemistry and material science, as it may offer valuable insights into efficient solar-energy harvesting. Recently, quantum coherent effects have been discovered in photosynthetic light harvesting, and their potential role on energy transfer has seen heated debate. Here, we perform an experimental quantum simulation of photosynthetic energy transfer using nuclear magnetic resonance (NMR). We show that an N- chromophore photosynthetic complex, with arbitrary structure and bath spectral density, can be effectively simulated by a system with log2 N qubits. The computational cost of simulating such a system with a theoretical tool, like the hierarchical equation of motion, which is exponential in N, can be potentially reduced to requiring a just polynomial number of qubits N using NMR quantum simulation. The benefits of performing such quantum simulation in NMR are even greater when the spectral density is complex, as in natural photosynthetic complexes. These findings may shed light on quantum coherence in energy transfer and help to provide design principles for efficient artificial light harvesting., Comment: 29 pages, 9 figures, 1 table

Published
2018
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43. Anion-induced chiral assembly: construction of Ag(I) coordination polymers for photocatalytic degradation of organic dyes.

Author

Huang, Chao, Liang, Jin-Xia, and Zhu, Bi-Xue

Abstract

A racemic bis(pyridyl) ligand (L) was synthesized and characterized following our previous work. Subsequently, a series of Ag(I) coordination polymers (CPs) were synthesized from this ligand with silver(I) salts containing nine different anions and further characterized by single-crystal X-ray diffraction analysis. The crystal structures of CPs 1–9 show that the anions play a vital role in the chiral assembly process of L with different silver(I) salts, resulting in homochiral or heterochiral complexes. CPs 1–3 exist as 2D homochiral conglomerates formed by spontaneous chiral resolution. CPs 4–8 exist as 1D heterochiral tube-like chains, and CP 9 adopts a 1D heterochiral zig-zag chain structure. Furthermore, CPs 2, 4, and 9 were chosen as representatives to investigate their photocatalytic performances for the degradation of organic dyes. The results showed that CP 4 is much more active than CPs 2 and 9 for the degradation of both rhodamine B (RhB) and methylene blue (MB) under UV light irradiation, and it is thus inferred that CPs 4–8 are suitable as potential photocatalysts for the degradation of RhB and MB in water. This work has revealed that the chiral assembly structures induced by anions lead to differences in their photocatalytic performances. [ABSTRACT FROM AUTHOR]

Published
2025
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50. MOF-based porous liquids towards a highly stressed and chemically resistant fire-safety polyurea elastomer.

Author

Song, Kunpeng, Zhang, Keshan, Bi, Xue, Hou, Boyou, Pan, Ye-Tang, Li, Xingyao, He, Jiyu, and Yang, Rongjie

Abstract

Metal–organic framework (MOF)-based functionalized porous liquids are promising candidates for efficient functional species, owing to their better storage stability, higher dispersibility, and convenient processing properties than solid MOF-based fillers. However, the structural design and synthesis strategy for such porous liquids have been a challenge so far. Herein, a porous flame retardant (UiO-66-NH2@PA@OAPS, U@PA@OA) was designed using UiO-66-NH2 as a precursor, 3-phosphonopropanoic acid (PA) as a flame-retardant ligand, and octa(aminophenyl) polyhedral oligomeric silsesquioxane (OAPS) as a modifier through post-synthesis modification strategies, such as ligand replacement, defect engineering, and surface modification. Later, it was utilized as a rigid guest and polysiloxane was employed as a mobile phase and a hydrophobic component to manufacture functionalized porous liquids (UiO-66-NH2@PA@OAPS PLs, U@PA@OA PLs). Advanced U@PA@OA PLs present favorable storage stability as well as compatibility with polyurea components. Impressively, U@PA@OA PLs with a 10 wt% loading (2 wt% U@PA@OA content) in polyurea can improve the limiting oxygen index value of the composites to 26.9% and pass the V-0 rating in the UL-94 test. Moreover, the peak of heat release rate, total heat release, and total smoke production of the polyurea composites are reduced by around 53.7, 36.3, and 34.0%, respectively, compared to neat polyurea. Moreover, the mechanical properties, impact resistance, and chemical resistance of PLs modified polyurea composites are also significantly enhanced. This work not only motivates researchers to design functionalized porous liquids rationally, but it is also expected to expand the application of composites in other potential fields. [ABSTRACT FROM AUTHOR]

Published
2024
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