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3. Serum HBsAg and HBcrAg is associated with inflammation in HBeAg-positive chronic hepatitis B patients

Author

Zhao, Jing, Bian, Dandan, Liao, Hao, Wang, Yang, Ren, Yan, Jiang, Yingying, Liu, Shuang, Chen, Xinyue, Hu, Zhongjie, Duan, Zhongping, Lu, Fengmin, Zheng, Sujun, Zhao, Jing, Bian, Dandan, Liao, Hao, Wang, Yang, Ren, Yan, Jiang, Yingying, Liu, Shuang, Chen, Xinyue, Hu, Zhongjie, Duan, Zhongping, Lu, Fengmin, and Zheng, Sujun

Abstract

Backgrounds & aimsLiver inflammation is the main risk factor for developing liver fibrosis, cirrhosis, and even hepatocellular carcinoma in chronic hepatitis B (CHB) patients. To replace biopsy, additional non-invasive biomarkers to diagnose and grade liver necroinflammation are urgently required in clinical practice. MethodNinety-four CHB patients, including 74 HBeAg-positive and 20 HBeAg-negative patients, were enrolled and started entecavir or adefovir therapy. Serum HBV RNA, HBV DNA, HBsAg, hepatitis B core-related antigen (HBcrAg), ALT and AST levels, as well as intrahepatic HBV DNA and cccDNA were measured at baseline and during treatment. Liver inflammation was assessed at baseline and month 60 by liver biopsy. Inflammation regression was defined as a >= 1-grade decrease according to the Scheuer scoring system. ResultsIn HBeAg-positive CHB patients, at baseline, serum HBsAg and HBcrAg levels negatively correlated with inflammation grade, while ALT and AST levels positively correlated with inflammation grade. AST plus HBsAg exhibited excellent diagnostic ability for significant inflammation with an AUROC of 0.896. After 60 months of antiviral treatment, almost all the patients' liver inflammation ameliorated to G1, and no patients had inflammation progression. ConclusionBesides ALT and AST, serum HBsAg and HBcrAg correlated with inflammation grade in HBeAg-positive CHB patients before NAs treatment. Moreover, the combination of HBsAg and AST exhibited excellent diagnostic ability for significant inflammation.

Published
2023

4. Serum HBV RNA is associated with liver fibrosis regression in HBeAg-positive chronic hepatitis B patients treated with nucleos(t)ide analogues

Author

Bian, Dandan, Zhao, Jing, Liao, Hao, Wang, Yang, Ren, Yan, Jiang, Yingying, Liu, Shuang, Chen, Xinyue, Hu, Zhongjie, Duan, Zhongping, Lu, Fengmin, Zheng, Sujun, Bian, Dandan, Zhao, Jing, Liao, Hao, Wang, Yang, Ren, Yan, Jiang, Yingying, Liu, Shuang, Chen, Xinyue, Hu, Zhongjie, Duan, Zhongping, Lu, Fengmin, and Zheng, Sujun

Abstract

Noninvasive methods for assessing hepatic fibrosis are clinically necessary. This study aims to explore HBV markers correlated with liver fibrosis and capable of diagnosing significant fibrosis and predicting fibrosis regression. Seventy-four HBeAg-positive chronic hepatitis B (CHB) patients were enrolled and started on entecavir or adefovir therapy. Serum HBV RNA, HBV DNA, HBsAg and hepatitis B core-related antigen (HBcrAg) levels were measured at baseline and during treatment. Liver fibrosis was assessed at baseline and month 60 by liver biopsy. Fibrosis regression was defined as Ishak fibrosis score decreased ≥1-point. At baseline, HBsAg, HBcrAg and HBV RNA levels had a stronger correlation with Ishak fibrosis score (r = −.441, p =.002; r = −.469, p =.001; r = −.398, p =.001) than APRI and FIB-4 (r =.321 p =.006; r =.371, p =.001). HBsAg >4 log10 IU/ml plus HBcrAg >7 log10 IU/ml or HBsAg >4 log10 IU/ml plus HBV RNA >5 log10 copies/ml exhibited the same excellent diagnostic ability for significant fibrosis with the AUROC of 0.857. After 60 months of antiviral treatment, 66.7% of patients who suffered significant fibrosis at baseline achieved fibrosis regression, and an HBV RNA decline from baseline to month 6 greater than 0.63 log10 copies/ml could predict the fibrosis regression at month 60. In conclusion, serum HBsAg, HBcrAg and HBV RNA are potential markers for predicting significant liver fibrosis. HBV RNA measurement would be particularly useful for monitoring hepatic fibrosis changes in HBeAg-positive CHB patients. © 2023 John Wiley & Sons Ltd.

Published
2023

5. Serum HBV RNA is associated with liver fibrosis regression in HBeAg‐positive chronic hepatitis B patients treated with nucleos(t)ide analogues

Author

Bian, Dandan, primary, Zhao, Jing, additional, Liao, Hao, additional, Wang, Yang, additional, Ren, Yan, additional, Jiang, Yingying, additional, Liu, Shuang, additional, Chen, Xinyue, additional, Hu, Zhongjie, additional, Duan, Zhongping, additional, Lu, Fengmin, additional, and Zheng, Sujun, additional

Published
2023
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9. Serum HBV RNA predicts HBeAg clearance and seroconversion in patients with chronic hepatitis B treated with nucleos(t)ide analogues

Author

Wang, Yang, Liao, Hao, Deng, Zhongping, Liu, Yanna, Bian, Dandan, Ren, Yan, Yu, Guangxin, Jiang, Yingying, Bai, Li, Liu, Shuang, Liu, Mei, Zhou, Li, Chen, Yu, Duan, Zhongping, Lu, Fengmin, Zheng, Sujun, Wang, Yang, Liao, Hao, Deng, Zhongping, Liu, Yanna, Bian, Dandan, Ren, Yan, Yu, Guangxin, Jiang, Yingying, Bai, Li, Liu, Shuang, Liu, Mei, Zhou, Li, Chen, Yu, Duan, Zhongping, Lu, Fengmin, and Zheng, Sujun

Abstract

This study evaluated the predictive value of serum HBV DNA, HBV RNA, HBcrAg, HBsAg, intrahepatic HBV DNA and cccDNA for HBeAg clearance and seroconversion during long-term treatment with nucleos(t)ide analogues (NAs) in patients with chronic hepatitis B (CHB). A single centre, prospective cohort of CHB patients was used for this study. Serum HBV RNA levels were retrospectively measured at baseline, 6, 12, 24, 36, 48, 60, 72 and 84 months post-NAs treatment. Serum HBsAg and HBcrAg levels were quantified at baseline, month 6, 60 and 72. Histological samples from liver biopsy at baseline and month 60 were analysed for intrahepatic HBV DNA and cccDNA. Eighty-three HBeAg-positive patients were enrolled with a median follow-up time of 108 months (range 18–138 months). Of them, 53 (63.86%) patients achieved HBeAg clearance, and 37 (44.58%) achieved HBeAg seroconversion. Cox multivariate analysis showed that only baseline HBV RNA was independently associated with HBeAg clearance and seroconversion (<5.45 log10copies/mL, HR = 5.06, 95% CI: 1.87–13.71, p =.001; HR = 3.38, 95% CI: 1.28–8.91, p =.01). The independent association with HBeAg clearance and seroconversion remained for HBV RNA levels at month 6 (<4.72 log10copies/mL, HR = 4.16, 95% CI: 1.61–10.72, p =.003; HR = 6.52, 95% CI: 1.85–22.94, p =.003) and month 12 (<4.08 log10 copies/mL, HR = 3.68, 95% CI: 1.96–6.90, p <.001; HR = 2.79, 95% CI: 1.31–5.94, p =.008). The AUCs of baseline HBV RNA for predicting the HBeAg clearance (0.83, 95% CI: 0.70–0.96, 0.83, 95% CI: 0.70–0.96 and 0.82, 95% CI: 0.69–0.95 respectively) and seroconversion (0.89, 95% CI: 0.77–1.00; 0.81, 95% CI: 0.66–0.95 and 0.84, 95% CI: 0.71–0.98 respectively) at month 36, 60 and 84 were higher than those of HBV DNA, HBsAg and HBcrAg. In conclusion, lower serum HBV RNA at baseline, month 6 and 12 post-NAs treatment could predict HBeAg clearance and seroconversion during long-term NAs treatment.

Published
2022

10. Sublethal chlorantraniliprole exposure induces autophagy and apoptosis through disrupting calcium homeostasis in the silkworm Bombyx mori.

Author

Ye, WenTao, Dai, MinLi, Bian, DanDan, Zhu, QingYu, Li, Xin, Sun, HaiNa, Li, FanChi, Wei, Jing, and Li, Bing

Subjects
SILKWORMS, CHLORANTRANILIPROLE, AUTOPHAGY, HOMEOSTASIS, NUCLEAR membranes, CALCIUM, APOPTOSIS
Abstract

The intensive application of chlorantraniliprole (CAP) leaves residues in the environment, posing a potential threat to non‐target organisms. In the present study, we investigated the adverse effects of sublethal CAP exposure on Bombyx mori. Sublethal CAP (0.02 mg/L) was shown to induce the release of intracellular Ca2+ in BmN cells. Meanwhile, Ca2+‐dependent genes were induced in the midgut at 72 h after CAP (0.01 mg/L) exposure, and damaged mitochondria, autophagosomes, nuclear membrane rupture and condensed chromatin were observed. Moreover, the key genes in the oxidative phosphorylation pathway were significantly down‐regulated. The transcript levels of autophagy‐related genes ATG6 and ATG8 were significantly up‐regulated, and the protein levels of LC3‐II and ATG7 were significantly increased by 3.72‐ and 3.33‐fold, respectively. Additionally, the transcript levels of the upstream genes in the apoptosis pathway (calpain and Apaf‐1) were significantly up‐regulated, the protein levels of the downstream gene caspase 3 and its cleaved form were significantly up‐regulated by 1.97‐ and 4.55‐fold, respectively, consistent with the elevated caspase 3 activity at 72 h. Collectively, these findings demonstrate that intracellular Ca2+ release induced by sublethal CAP inhibits oxidative phosphorylation pathway, which causes mitochondrial dysfunction, leading to autophagy and apoptosis in the midgut of B. mori. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Serum HBV RNA predicts HBeAg clearance and seroconversion in patients with chronic hepatitis B treated with nucleos(t)ide analogues

Author

Wang, Yang, primary, Liao, Hao, additional, Deng, Zhongping, additional, Liu, Yanna, additional, Bian, Dandan, additional, Ren, Yan, additional, Yu, Guangxin, additional, Jiang, Yingying, additional, Bai, Li, additional, Liu, Shuang, additional, Liu, Mei, additional, Zhou, Li, additional, Chen, Yu, additional, Duan, Zhongping, additional, Lu, Fengmin, additional, and Zheng, Sujun, additional

Published
2022
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15. Serum HBV DNA plus RNA reflecting cccDNA level before and during NAs treatment in HBeAg positive CHB patients

Author

Wang, Yang, primary, Liu, Yanna, additional, Liao, Hao, additional, Deng, Zhongping, additional, Bian, Dandan, additional, Ren, Yan, additional, Yu, Guangxin, additional, Jiang, Yingying, additional, Bai, Li, additional, Liu, Shuang, additional, Liu, Mei, additional, Zhou, Li, additional, Chen, Yu, additional, Chen, Xinyue, additional, Duan, Zhongping, additional, Lu, Fengmin, additional, and Zheng, Sujun, additional

Published
2022
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16. Imbalance of intestinal microbial homeostasis caused by acetamiprid is detrimental to resistance to pathogenic bacteria in Bombyx mori

Author

Li, Fanchi, primary, Li, Mengxue, additional, Zhu, Qingyu, additional, Mao, Tingting, additional, Dai, Minli, additional, Ye, Wentao, additional, Bian, Dandan, additional, Su, Wujie, additional, Feng, Piao, additional, Ren, Yuying, additional, Sun, Haina, additional, Wei, Jing, additional, and Li, Bing, additional

Published
2021
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17. Serum HBV RNA Predicts HBeAg Clearance and Seroconversion in Patients with Chronic Hepatitis B Treated with Nucleos(t)Ide Analogues

Author

Wang, Yang, primary, Liao, Hao, additional, Deng, Zhongping, additional, liu, Yanna, additional, bian, Dandan, additional, Ren, Yan, additional, Yu, Guangxin, additional, Jiang, yingying, additional, Bai, Li, additional, Liu, Shuang, additional, Liu, Mei, additional, Zhou, Li, additional, Chen, Yu, additional, Duan, Zhongping, additional, Zheng, Sujun, additional, and Lu, fengmin, additional

Published
2021
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22. Upregulation of Serum Sphingosine (d18:1)-1-P Potentially Contributes to Distinguish HCC Including AFP-Negative HCC From Cirrhosis

Author

Jiang, Yingying, primary, Tie, Cai, additional, Wang, Yang, additional, Bian, Dandan, additional, Liu, Mei, additional, Wang, Ting, additional, Ren, Yan, additional, Liu, Shuang, additional, Bai, Li, additional, Chen, Yu, additional, Duan, Zhongping, additional, Zheng, Sujun, additional, and Zhang, Jinlan, additional

Published
2020
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27. Dispersion characteristics of nanometer-scaled silicon nitride suspended membrane waveguides

Author

Chen Shao-Wu, Bian Dandan, and Lei Xun

Subjects
Materials science, Physics::Optics, 02 engineering and technology, 01 natural sciences, law.invention, 010309 optics, Frequency comb, chemistry.chemical_compound, Optics, law, 0103 physical sciences, Dispersion (optics), Materials Chemistry, Electrical and Electronic Engineering, Range (particle radiation), business.industry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Wavelength, Membrane, Silicon nitride, chemistry, Nanometre, 0210 nano-technology, business, Waveguide
Abstract

We investigate the dispersion properties of nanometer-scaled silicon nitride suspended membrane waveguides around the communication wavelength and systematically study their relationship with the key structural parameters of the waveguide. The simulation results show that a suspended membrane waveguide can realize anomalous dispersion with a relatively thinner silicon nitride thickness in the range of 400 to 600 nm, whereas, for the same membrane thickness, a conventional rib or strip silicon nitride waveguide cannot support anomalous dispersion. In particular, a waveguide with 400 nm silicon nitride thickness and deep etch depth (r = 0.05) exhibits anomalous dispersion around the communication wavelength when the waveguide width ranges from 990 to 1255 nm, and the maximum dispersion is 22.56 ps/(nmkm). This specially designed anomalous dispersion silicon nitride waveguide is highly desirable for micro-resonator based optical frequency combs due to its potential to meet the phase-matching condition required for cascaded four-wave-mixing.

Published
2016

30. Molecular cloning and expression analysis of the highly conserved eukaryotic translation initiation factor 5A (eIF-5A) from Antheraea pernyi.

Author

BIAN, Dandan, Xiaoming ZHAO, Li CHEN, Jiwu TIAN, Qiuning LIU, Chunlin ZHOU, and Boping TANG

Subjects
*ANTHERAEA, *INSECT phylogeny, *MOLECULAR cloning, *INSECT genetics, *GENE expression, *CHINESE oak silkworm, *TRANSLATION initiation factors (Biochemistry)
Abstract

Eukaryotic initiation factor 5A (eIF-5A) is a highly conserved protein found in all eukaryotic organisms that plays a key role in the regulation of many cellular processes including translation elongation, cell proliferation, programmed cell death, mRNA turnover and decay, and abiotic stress responses. In this study, the eIF-5A gene from the Chinese oak silkworm Antheraea pernyi (Lepidoptera: Saturniidae) was characterized. The full-length ApeIF-5A cDNA of 1056 BP includes a 50-untranslated region (UTR) of 138 BP, a 30-UTR of 435 BP, and an open reading frame of 483 BP encoding a polypeptide of 160 amino acids. The deduced ApeIF-5A protein shares 99 %, 82 %, and 72 % sequence identity with orthologs in Bombyx mori, Drosophila melanogaster and Homo sapiens, indicating high conservation during animal evolution. Real-time quantitative reverse transcription PCR revealed expression in all four developmental stages and in all nine tissues tested, consistent with an important role in development. After challenge with lipopolysaccharide, the expression levels of ApeIF-5A were markedly upregulated. Phylogenetic analysis of amino acid sequences revealed A. pernyi eIF-5A was closely related to B. mori eIF-5A, consistent with traditional classification and other molecular data. The results indicate the potential value of eIF-5A in phylogenetic analysis. [ABSTRACT FROM AUTHOR]

Published
2018
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