1. Regulation of gene expression by glycolytic and gluconeogenic enzymes.
- Author
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Bian, Xueli, Jiang, Hongfei, Meng, Ying, Li, Ying-ping, Fang, Jing, and Lu, Zhimin
- Subjects
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GENETIC regulation , *CELL metabolism , *ENZYMES , *PROTEIN kinases , *GENE expression , *CHROMATIN-remodeling complexes , *MONOCARBOXYLATE transporters - Abstract
Gene transcription and cell metabolism are two fundamental biological processes that mutually regulate each other. Upregulated or altered expression of glucose metabolic genes in glycolysis and gluconeogenesis is a major driving force of enhanced aerobic glycolysis in tumor cells. Importantly, glycolytic and gluconeogenic enzymes in tumor cells acquire moonlighting functions and directly regulate gene expression by modulating chromatin or transcriptional complexes. The mutual regulation between cellular metabolism and gene expression in a feedback mechanism constitutes a unique feature of tumor cells and provides specific molecular and functional targets for cancer treatment. Gene transcription and cell metabolism mutually regulate each other. Glycolytic and gluconeogenic enzymes in tumor cells directly regulate gene expression by modulating chromatin or transcriptional complexes. Glycolytic and gluconeogenic enzymes regulate gene transcription in enzymatic activity-dependent or -independent ways. Glycolytic enzymes can function as protein kinases in the nucleus. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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