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1. Creatinine correction to account for fluid overload in children with acute respiratory distress syndrome treated with extracorporeal membrane oxygenation: an initial exploratory report

Author

Redant, Sébastien, De Bels, David, Barbance, Océane, Massaut, Jacques, Honoré, Patrick M., Taccone, Fabio S., and Biarent, Dominique

Subjects
Pediatrics, Blood oxygenation, Extracorporeal -- Patient outcomes -- Demographic aspects, Creatinine -- Patient outcomes -- Demographic aspects, Acute respiratory distress syndrome -- Demographic aspects -- Drug therapy -- Patient outcomes, Health
Abstract

Background Creatinine is distributed between the intracellular and extracellular compartments, and as a result, the measurement of its concentration is strongly related to the fluid status of the patient. An interest has been shown in correcting measured serum creatinine levels according to the fluid balance in order to better specify the degree of acute kidney injury (AKI). Methods We conducted a retrospective observational study of 33 children, aged 0 to 5 years, admitted to the pediatric intensive care unit for acute respiratory distress syndrome treated by extracorporeal membrane oxygenation. We compared measured and corrected creatinine and assessed the degree of agreement between these values using both Cohen's kappa and Krippendorff's alpha coefficient. Results In our cohort, 37% of the classifications made according to measured creatinine levels were erroneous and, in the majority of cases, the degree of AKI was underestimated. Conclusion Correction of the measured creatinine value according to the degree of fluid overload may result in more accurate diagnosis of AKI., Author(s): Sébastien Redant [sup.1] [sup.2] , David De Bels [sup.1] , Océane Barbance [sup.2] , Jacques Massaut [sup.1] , Patrick M. Honoré [sup.1] , Fabio S. Taccone [sup.3] , Dominique [...]

Published
2022
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2. A multicentric, randomized, controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children—BENEFICIAL trial.

Author

De Cock, Pieter A., Colman, Roos, Amza, Anca, De Paepe, Peter, De Pla, Hans, Vanlanduyt, Lieselot, Van der Linden, Dimitri, Schelstraete, Petra, Cools, Filip, Clarysse, Alexander, Debouver, Phebe, Biarent, Dominique, Vens, Daphne Vania, Smits, Anne, Godart, Valerie, Vanhaesebrouck, Sophie, Dhont, Evelyn, Bordon, Victoria, Mauel, Reiner, and Van Der Werff Ten Bosch, Jutte

Subjects
CRITICALLY ill children, DRUG monitoring, PEDIATRIC intensive care, NEONATAL intensive care, ACUTE kidney failure
Abstract

Background : Vancomycin is a commonly prescribed antibiotic to treat serious Gram-positive infections in children. The efficacy of vancomycin is known to be directly related to the pharmacokinetic/pharmacodynamic (PK/PD) index of the area under the concentration–time curve (AUC) divided by the minimal inhibitory concentration (MIC) of the pathogen. In most countries, steady-state plasma concentrations are used as a surrogate parameter for this target AUC/MIC, but this practice has some drawbacks. Hence, AUC-based dosing using model-informed precision dosing (MIPD) tools has been proposed for increasing the target attainment rate and reducing vancomycin-related nephrotoxicity. Solid scientific evidence for these claimed benefits is lacking in children. This randomized controlled trial aims to investigate the large-scale utility of MIPD dosing of vancomycin in critically ill children. Methods: Participants from 14 neonatal intensive care, pediatric intensive care, and pediatric hemo-oncology ward units from 7 hospitals are randomly allocated to the intervention or standard-of-care comparator group. In the intervention group, a MIPD dosing calculator is used for AUC-based dosing, in combination with extra sampling for therapeutic drug monitoring in the first hours of treatment, as compared to standard-of-care. An AUC24h between 400 and 600 is targeted, assuming an MIC of 1 mg/L. Patients in the comparator group receive standard-of-care dosing and monitoring according to institutional guidelines. The primary endpoint is the proportion of patients reaching the target AUC24h/MIC of 400–600 between 24 and 48 h after the start of vancomycin treatment. Secondary endpoints are the proportion of patients with (worsening) acute kidney injury during vancomycin treatment, the proportion of patients reaching target AUC24h/MIC of 400–600 between 48 and 72 h after the start of vancomycin treatment, time to clinical cure, ward unit length-of-stay, hospital length-of-stay, and 30-day all-cause mortality. Discussion: This trial will clarify the propagated benefits and provide new insights into how to optimally monitor vancomycin treatment in critically ill children. Trial registration: Eudract number: 2019–004538-40. Registered on 2020–09-08 ClinicalTrials.gov NCT046666948. Registered on 2020–11-28 [ABSTRACT FROM AUTHOR]

Published
2024
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9. What works in paediatric CPR?

Author

Skellett, Sophie, Biarent, Dominique, and Nadkarni, Vinay

Subjects
Children's hospitals, Pediatric anesthesia, Pediatric intensive care, Health care industry
Abstract

Author(s): Sophie Skellett [sup.1], Dominique Biarent [sup.2], Vinay Nadkarni [sup.3] [sup.4] [sup.5] Author Affiliations: (1) 0000 0004 5902 9895, grid.424537.3, Department of Paediatric Intensive Care, Great Ormond Street Hospital for [...]

Published
2018
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10. EuReCa ONE⿿27 Nations, ONE Europe, ONE Registry: A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

Author

Kaufmann, Marc, Thaler, Markus, Maier, Martin, Prause, Gerhard, Trimmel, Helmut, de Longueville, Diane, Preseau, Thierry, Biarent, Dominique, Melot, Christian, Mpotos, Nicolas, Monsieurs, Koen, Van de Voorde, Patrick, Vanhove, Marie, Lievens, Pascale, Faniel, Mathias, Keleuva, Slobodanka, Lazarevic, Milan, Ujevic, Radmila Majhen, Devcic, Mato, Bardak, Branka, Barisic, Fabijan, Anticevic, Silvija Hunyadi, Georgiou, Marios, Truhláſ, Anatolij, Knor, Jiſí, Smržová, Eva, Sviták, Roman, Šín, Robin, Mokrejš, Petr, Lippert, Freddy K., Hallikainen, Juhana, Hoikka, Marko, Iirola, Timo, Jama, Timo, Jäntti, Helena, Jokisalo, Raimo, Jousi, Milla, Kirves, Hetti, Kuisma, Markku, Laine, Jukka, Länkimäki, Sami, Loikas, Petri, Lund, Vesa, Määttä, Teuvo, Nal, Heini, Niemelä, Heimo, Portaankorva, Petra, Pylkkänen, Marko, Sainio, Marko, Setälä, Piritta, Tervo, Jerry, Väyrynen, Taneli, Murgue, Davy, Champenois, Anne, Fournier, Marc, Meyran, Daniel, Tabary, Romain, Avondo, Aurélie, Gelin, Gelin, Simonnet, Bruno, Joly, Marc, Megy-Michoux, Isabelle, Paringaux, Xavier, Duffait, Yves, Vial, Michael, Segard, Julien, Narcisse, Sophie, Hamban, David, Hennache, Jonathan, Thiriez, Sylvain, Doukhan, Mathieu, Vanderstraeten, Carine, Morel, Jean-Charles, Majour, Gilles, Michenet, Corinne, Tritsch, Laurent, Dubesset, Marc, Peguet, Olivier, Pinero, David, Guillaumee, Fréderic, Fuster, Patrick, Ciacala, Jean-François, Jardel, Benoît, Letarnec, Jean-Yves, Goes, Frank, Gosset, Pierre, Vergne, Muriel, Bar, Christian, Branche, Fabienne, Prineau, Stevens, Lagadec, Steven, Cornaglia, Carole, Ursat, Cécile, Bertrand, Philippe, Agostinucci, Jean-Marc, Nadiras, Pierre, de Linares, Géraldine Gonzales, Jacob, Line, Revaux, François, Pernot, Thomas, Roudiak, Nathalie, Ricard-Hibon, Agnès, Villain-Coquet, Laurent, Beckers, Stefan, Hanff, Thomas, Strickmann, Bernd, Wiegand, Nicolai, Wilke, Petra, Sues, Harald, Bogatzki, Stefan, Baumeier, Wolfgang, Pohl, Kai, Werner, Bert, Fischer, Hans, Zeng, Torsten, Popp, Erik, Günther, Andreas, Hochberg, Andreas, Lechleuthner, Alex, Schewe, Jens-Christian, Lemke, Hans, Wranze-Bielefeld, Erich, Bohn, Andreas, Roessler, Markus, Naujoks, Frank, Sensen, Frank, Esser, Torben, Fischer, Matthias, Messelken, Martin, Rose, Christopher, Schlüter, Gabriele, Lotz, Wolfgang, Corzilius, Michael, Muth, Claus-Martin, Diepenseifen, Christian, Tauchmann, Björn, Birkholz, Torsten, Flemming, Andreas, Herrmann, Stefanie, Kreimeier, Uwe, Kill, Clemens, Marx, Frank, Schröder, Ralph, Lenz, Wolfgang, Botini, Glykeria, Grigorios, Barakos, Giannakoudakis, Nikolaos, Zervopoulos, Michail, Papangelis, Dimitrios, Petropoulou-Papanastasiou, Sofia, Liaskos, Themistoklis, Papanikolaou, Spyridon, Karabinis, Andreas, Zentay, Attila, ÿorsteinsson, Hólmgeir, Gilsdóttir, Anna, Birgisson, Svavar A., Guðmundsson, Fjölnir Freyr, Hreiðarsson, Hallgrímur, ÿrnason, Björgvin, Hermannsson, Hermann, Björnsson, Gísli, Friðriksson, Brynjar ÿór, Baldursson, Gunnar, Höskuldsson, ÿrmann, Valgarðsdottir, Jórunn, ÿsmundardóttir, Matthildur, Guðmundsson, Guðmundur, Kristjánsson, Hjörtur, ÿórarinsson, Eyþór Rúnar, Guðlaugsson, Jón, Skarphéðinsson, Sigurður, Peratoner, Alberto, Santarelli, Andrea, Sabetta, Cesare, Gordini, Giovanni, Sesana, Giovanni, Giudici, Riccardo, Savastano, Simone, Pellis, Tommaso, Beissel, Jean, Uhrig, Jean, Manderscheid, Tom, Klop, Marco, Stammet, Pascal, Koch, Marc, Welter, Philippe, Schuman, Robert, Bruins, Wendy, Amin, Hesam, Braa, Nina, Bratland, Staale, Buanes, Eirik Alnes, Draegni, Tomas, Johnsen, Knut Roar, Mathisen, Wenche Torunn, Oedegaarden, Terje, Oppedal, Marie, Reksten, Alf Stolt-Nielsen, Roedsand, Mats Eirik, Steen-Hansen, Jon Erik, Dyrda, Marta, Frejlich, Anna, MaciĿg, Sſawomir, Osadnik, Sonia, Weryk, Ireneusz, Mendonça, Eugénio, Freitas, Carlos, Cruz, Pinto, Caldeira, Carmo, Barros, José, Vale, Luis, Brazão, António, Jardim, Nuno, Rocha, Fernanda, Duarte, Ricardo, Fernandes, Nicodemos, Ramos, Pedro, Jardim, Margarida, Reis, Miguel, Ribeiro, Romulo, Zenha, Sérgio, Fernandes, Jorge, Francisco, Juan, Assis, David, Abreu, Fernanda, Freitas, Dinarte, Ribeiro, Leonardo, Azevedo, Paulo, Calafatinho, Débora, Jardim, Rui, Pestana, Aleixo, Faria, Rui, Oprita, Bogdan, Grasu, Alis, Nedelea, Paul, Sovar, Sorina, Agapi, Florin, KliĿkoviĿ, Aleksandar, LaziĿ, Aleksandra, NikoliĿ, Bogdan, Zivanovic, Bogdan, MartinoviĿ, Branislav, MilenkoviĿ, Dušan, Damir, HuseinoviĿ, Koprivica, Jovanka, JakšiĿ, Kornelija Horvat, Pajor, Margit, MiliĿ, Saša, VidoviĿ, Mirko, Glamoclija, Radojka Petrovic, Andjelic, Sladjana, Sladjana, Vlajovic, BabiĿ, Zlatko, Fišer, Zlatko, Androvic, Peter, Bajerovska, Lubica, Chabron, Miroslav, Dobias, Viliam, Havlikova, Eva, Horanova, Bozena, Kratochvilova, Renata, Kubova, Dana, Murgas, Jan, Patras, Juraj, Simak, Ladislav, Snarskij, Vladimir, Zaviaticova, Zuzana, Zuffova, Marcela, Roig, Francesc Escalada, Santos, Luis Sánchez, Sucunza, Alfredo Echarri, Cordero Torres, Juan A., Muñoz, Guadalupe Inza, del Valle, Marta Martínez, Rozalen, Isabel Ceniceros, Sánchez, Enrique Martín, Berlanga, María Victoria Raúl Canabal, Olalde, Karlos Ibarguren, Ruiz Azpiazu, José I., García-Ochoa, María José, López-Navarro, Rafael Zoyo, Adsuar Quesada, José M., Cortés Ramas, José A., Mellado Vergel, Francisco J., López Messa, Juan B., del Valle, Patricia Fernández, Anselmi, Luciano, Benvenuti, Breganzona Claudio, Batey, Nigel, Ambulance, Yorkshire, Booth, Scott, Bucher, Patricia, Deakin, Charles D., Duckett, Jay, Ji, Chen, Loughlin, Nancy, Lumley-Holmes, Jenny, Lynde, Jessica, Mersom, Frank, Ramsey, Carly, Robinson, Clare, Spaight, Robert, Dosanjh, Sukhdeep, Virdi, Gurkamal, Whittington, Andrew, Gräsner, Jan-Thorsten, Lefering, Rolf, Koster, Rudolph W., Masterson, Siobhán, Böttiger, Bernd W., Herlitz, Johan, Wnent, Jan, Tjelmeland, Ingvild B.M., Ortiz, Fernando Rosell, Maurer, Holger, Baubin, Michael, Mols, Pierre, HadžibegoviĿ, Irzal, Ioannides, Marios, Škulec, Roman, Wissenberg, Mads, Salo, Ari, Hubert, Hervé, Nikolaou, Nikolaos I., Lóczi, Gerda, Svavarsdóttir, Hildigunnur, Semeraro, Federico, Wright, Peter J., Clarens, Carlo, Pijls, Ruud, Cebula, Grzegorz, Correia, Vitor Gouveia, Cimpoesu, Diana, Raffay, Violetta, Trenkler, Stefan, Markota, Andrej, Strömsöe, Anneli, Burkart, Roman, Perkins, Gavin D., and Bossaert, Leo L.

Published
2016
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11. Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest: A Statement for Healthcare Professionals From a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian and New Zealand Council on Resuscitation, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Southern Africa, Resuscitation Council of Asia); and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation

Author

Perkins, Gavin D., Jacobs, Ian G., Nadkarni, Vinay M., Berg, Robert A., Bhanji, Farhan, Biarent, Dominique, Bossaert, Leo L., Brett, Stephen J., Chamberlain, Douglas, de Caen, Allan R., Deakin, Charles D., Finn, Judith C., Gräsner, Jan-Thorsten, Hazinski, Mary Fran, Iwami, Taku, Koster, Rudolph W., Lim, Swee Han, Ma, Matthew Huei-Ming, McNally, Bryan F., Morley, Peter T., Morrison, Laurie J., Monsieurs, Koenraad G., Montgomery, William, Nichol, Graham, Okada, Kazuo, Ong, Marcus Eng Hock, Travers, Andrew H., and Nolan, Jerry P.

Published
2015
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12. European Resuscitation Council Guidelines for Resuscitation 2015: Section 1. Executive summary

Author

Khalifa, Gamal Eldin Abbas, Alfonzo, Annette, Arntz, Hans-Richard, Askitopoulou, Helen, Bellou, Abdelouahab, Beygui, Farzin, Biarent, Dominique, Bingham, Robert, Bierens, Joost J.L.M., Böttiger, Bernd W., Bossaert, Leo L., Brattebø, Guttorm, Brugger, Hermann, Bruinenberg, Jos, Cariou, Alain, Carli, Pierre, Cassan, Pascal, Castrén, Maaret, Chalkias, Athanasios F., Conaghan, Patricia, Deakin, Charles D., De Buck, Emmy D.J., Dunning, Joel, De Vries, Wiebe, Evans, Thomas R., Eich, Christoph, Gräsner, Jan-Thorsten, Greif, Robert, Hafner, Christina M., Handley, Anthony J., Haywood, Kirstie L., Hunyadi-Antičević, Silvija, Koster, Rudolph W., Lippert, Anne, Lockey, David J., Lockey, Andrew S., López-Herce, Jesús, Lott, Carsten, Maconochie, Ian K., Mentzelopoulos, Spyros D., Meyran, Daniel, Monsieurs, Koenraad G., Nikolaou, Nikolaos I., Nolan, Jerry P., Olasveengen, Theresa, Paal, Peter, Pellis, Tommaso, Perkins, Gavin D., Rajka, Thomas, Raffay, Violetta I., Ristagno, Giuseppe, Rodríguez-Núñez, Antonio, Roehr, Charles Christoph, Rüdiger, Mario, Sandroni, Claudio, Schunder-Tatzber, Susanne, Singletary, Eunice M., Skrifvars, Markus B., Smith, Gary B., Smyth, Michael A., Soar, Jasmeet, Thies, Karl-Christian, Trevisanuto, Daniele, Truhlář, Anatolij, Vandekerckhove, Philippe G., de Voorde, Patrick Van, Sunde, Kjetil, Urlesberger, Berndt, Wenzel, Volker, Wyllie, Jonathan, Xanthos, Theodoros T., and Zideman, David A.

Published
2015
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13. Part 6: Pediatric basic life support and pediatric advanced life support: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

Author

Argent, Andrew C., Berg, Marc D., Bingham, Robert M., Bruinenberg, Jos, Chameides, Leon, Coulthard, Mark G., Couto, Thomaz B., Dalziel, Stuart R., Duff, Jonathan P., Egan, Jonathan R., Eich, Christoph, Gene, Ong Yong-Kwang, Fink, Ericka L., Friess, Stuart H., Fuchs, Susan, Hickey, Robert, Hunt, Elizabeth A., Ikeyama, Takanari, Kissoon, Niranjan, MacLaren, Graeme, Marino, Bradley, McBride, Mary E., Parker, Melissa J., Raymond, Tia T., Rey, Corsino, Rodriguez-Nunez, Antonio, de Sá, Fernanda V.M., Schexnayder, Stephen M., Shibata, Audrey R. Ogawa, Singhi, Sunit C., Thiagarajan, Ravi R., Tijssen, Janice A., Topjian, Alexis, Urbano, Javier, Were, Wilson M., Maconochie, Ian K., de Caen, Allan R., Aickin, Richard, Atkins, Dianne L., Biarent, Dominique, Guerguerian, Anne-Marie, Kleinman, Monica E., Kloeck, David A., Meaney, Peter A., Nadkarni, Vinay M., Ng, Kee-Chong, Nuthall, Gabrielle, Reis, Ameila G., Shimizu, Naoki, Tibballs, James, and Pintos, Remigio Veliz

Published
2015
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14. European Resuscitation Council Guidelines for Resuscitation 2015: Section 10. Education and implementation of resuscitation

Author

Ballance, John H.W., Barelli, Alessandro, Biarent, Dominique, Bossaert, Leo, Castrén, Maaret, Handley, Anthony J., Lott, Carsten, Maconochie, Ian, Nolan, Jerry P., Perkins, Gavin, Raffay, Violetta, Ringsted, Charlotte, Soar, Jasmeet, Schlieber, Joachim, Van de Voorde, Patrick, Wyllie, Jonathan, Zideman, David, Greif, Robert, Lockey, Andrew S., Conaghan, Patricia, Lippert, Anne, De Vries, Wiebe, and Monsieurs, Koenraad G.

Published
2015
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16. Hyperoxaluria: An early diagnosis will allow a timely combined renal and liver transplantations to avoid irreversible damages to all other organs

Author

Kottos, Elisa, Adams, Brigitte, Biarent, Dominique, Beretta-Piccoli, Xavier, Ismaili, Khalid, De Bels, David, Honore, Patrick M., and Redant, Sebastien

Subjects
coralliform calcification, hyperoxaluria, Internal Medicine, Case Report, nephronophtisis, L-alanine-glyoxylate aminotransferase, urologic and male genital diseases, sequential transplant
Abstract

A 4-month-old patient was admitted to the emergency room for vomiting, weight gain, food refusal and hypertension. Blood gases showed a metabolic acidosis with increased anion gap. Laboratory finding revealed severe renal failure (creatinine 8 mg/dL). Renal ultrasound showed an important hyperechogenicity of the parenchyma with loss of cortico-medullar differentiation suggesting a nephronophytosis. Genetic testing was negative. Urine oxalate levels were increased to 140 μmol/L. New genetic tests were positive for type I hyperoxaluria. The authors discuss the management of hyperoxaluria.

Published
2021

18. Impact of a VAP bundle in Belgian intensive care units

Author

Jadot, Laurent, Huyghens, Luc, De Jaeger, Annick, Bourgeois, Marc, Biarent, Dominique, Higuet, Adeline, de Decker, Koen, Vander Laenen, Margot, Oosterlynck, Baudewijn, Ferdinande, Patrick, Reper, Pascal, Brimioulle, Serge, Van Cromphaut, Sophie, De Clety, Stéphane Clement, Sottiaux, Thierry, and Damas, Pierre

Published
2018
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19. Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases

Author

Goemanne, Sophie, Tilmanne, Anne, Biarent, Dominique, Smeesters, Pierre, Simoni, Paolo, Mahadeb, Bhavna Ansuya, Vicinanza, Alfredo, Goemanne, Sophie, Tilmanne, Anne, Biarent, Dominique, Smeesters, Pierre, Simoni, Paolo, Mahadeb, Bhavna Ansuya, and Vicinanza, Alfredo

Abstract

Background Staphylococcus aureus is a well-known bacterium associated with carriage and responsible for different types of infections. The Panton-Valentine leucocidin ( PVL ) is a key virulence factor causing tissue necrosis. PVL can, however, be present in both benign and life-threatening infections. Case reports and management We present three pediatric severe infections occurring over a period of only three weeks, in February 2021, and caused by genetically unrelated methicillin-sensitive Staphylococcus aureus producing PVL in a tertiary children’s hospital in Belgium. The first one presented with necrotizing pneumonia, the second one with a neck abscess extended to the mediastinum, and the last one had sacral osteomyelitis complicated by endocarditis. The management of these infections is mostly based on expert opinions. The most appropriate treatment seems to be the combination of early surgical drainage of infected collections with an antibiotic regimen associating two antibiotics; beta-lactams and either clindamycin or linezolid. Human immunoglobulins also appear to be useful as adjunctive therapy. Conclusion PVL -producing Staphylococcus aureus is associated with life-threatening infections in children. Prompt management is needed including surgery and appropriate antibiotic regimens., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

20. Increasing burden of viral bronchiolitis in the pediatric intensive care unit; an observational study

Author

Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Bont, Child Health, Infectiezieken, Linssen, Rosalie S., Teirlinck, Anne C., van Boven, Michiel, Biarent, Dominique, Stona, Luca, Amigoni, Angela, Comoretto, Rosanna I., Leteurtre, Stephane, Bruandet, Amélie, Bentsen, Gunnar K., Drage, Inger Marie, Wang, Xin, Campbell, Harry, van Woensel, Job B.M., Bont, Louis, Bem, Reinout A., Infectieziekten onderzoek1 (Bont), Infection & Immunity, CTI Bont, Child Health, Infectiezieken, Linssen, Rosalie S., Teirlinck, Anne C., van Boven, Michiel, Biarent, Dominique, Stona, Luca, Amigoni, Angela, Comoretto, Rosanna I., Leteurtre, Stephane, Bruandet, Amélie, Bentsen, Gunnar K., Drage, Inger Marie, Wang, Xin, Campbell, Harry, van Woensel, Job B.M., Bont, Louis, and Bem, Reinout A.

Published
2022

22. Survival after out-of-hospital cardiac arrest in Belgium - 5 years of experience of the Belgian’s Cardiac arrest registry B-CAR.

Author

Longueville Diane, de, primary, Bartiaux, Magali, primary, Malinverni, Stefano, primary, Van Belleghem, Vincent, primary, Desmet, Francis, primary, Penaloza, Andrea, primary, Monsieurs, Koen, primary, Dewitte, Ken, primary, Vermeulen, Griet, primary, Domont, Pierre, primary, Denoël, Paule, primary, Manara, Alessandro, primary, Hubloue, Ives, primary, Scheyltjens, Simon, primary, Olivier, Vermylen,, primary, Wilmin, Stephan, primary, Marie, Vanhove, primary, Lievens, Pascale, primary, Biarent, Dominique, primary, Jeanmaire, Mathieu, primary, Polikipis, Magdalani, primary, Delmarcelle, Didier, primary, Fanniel, Mathias, primary, Leach, Robert, primary, Yerna, Michèle, primary, Abassi, Musa, primary, and Jacques, Jean-Marie, primary

Published
2022
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23. Increasing burden of viral bronchiolitis in the pediatric intensive care unit; an observational study

Author

Linssen, Rosalie S., primary, Teirlinck, Anne C., additional, van Boven, Michiel, additional, Biarent, Dominique, additional, Stona, Luca, additional, Amigoni, Angela, additional, Comoretto, Rosanna I., additional, Leteurtre, Stephane, additional, Bruandet, Amélie, additional, Bentsen, Gunnar K., additional, Drage, Inger Marie, additional, Wang, Xin, additional, Campbell, Harry, additional, van Woensel, Job B.M., additional, Bont, Louis, additional, and Bem, Reinout A., additional

Published
2022
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25. P088 Survival after out-of-hospital cardiac arrest in Belgium - 5 years of experience of the Belgian's Cardiac arrest registry B-CAR

Author

Diane de Longueville, Bartiaux Magali, Malinverni Stefano, Vincent Van Belleghem, Desmet Francis, Penaloza Andrea, Monsieurs Koen, Dewitte Ken, Vermeulen Griet, Domont Pierre, Vannuffelen Marc, Denoël Paule, Manara Alessandro, Hubloue Ives, Scheyltjens Simon, Vermylen Olivier, Wilmin Stephan, Vanhove Marie, Lievens Pascale, Biarent Dominique, Jeanmaire Mathieu, Polikipis Magda, Delmarcelle Didier, Faniel Mathias, Leach Robert, Yerna Michèle, Jacques Jean-Marie, Meurant Virginie, Abbasi Musa, and Mols Pierre

Subjects
Emergency Medicine, Emergency Nursing, Cardiology and Cardiovascular Medicine
Published
2022

27. Part 10: Paediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations

Author

de Caen, Allan R., Kleinman, Monica E., Chameides, Leon, Atkins, Dianne L., Berg, Robert A., Berg, Marc D., Bhanji, Farhan, Biarent, Dominique, Bingham, Robert, Coovadia, Ashraf H., Hazinski, Mary Fran, Hickey, Robert W., Nadkarni, Vinay M., Reis, Amelia G., Rodriguez-Nunez, Antonio, Tibballs, James, Zaritsky, Arno L., and Zideman, David

Published
2010
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32. To ventilate or not to ventilate during bystander CPR — A EuReCa TWO analysis

Author

Wnent, Jan, primary, Tjelmeland, Ingvild, additional, Lefering, Rolf, additional, Koster, Rudolph W., additional, Maurer, Holger, additional, Masterson, Siobhán, additional, Herlitz, Johan, additional, Böttiger, Bernd W., additional, Ortiz, Fernando Rosell, additional, Perkins, Gavin D., additional, Bossaert, Leo, additional, Moertl, Maximilian, additional, Mols, Pierre, additional, Hadžibegović, Irzal, additional, Truhlář, Anatolij, additional, Salo, Ari, additional, Baert, Valentine, additional, Nagy, Eniko, additional, Cebula, Grzegorz, additional, Raffay, Violetta, additional, Trenkler, Stefan, additional, Markota, Andrej, additional, Strömsöe, Anneli, additional, Gräsner, Jan-Thorsten, additional, Alihodžić, Hajriz, additional, Ioannides, Marios, additional, Wissenberg, Mads, additional, Escutnaire, Josephine, additional, Nikolaou, Nikolaos, additional, Jonsson, Bergthor Steinn, additional, Wright, Peter, additional, Semeraro, Federico, additional, Clarens, Carlo, additional, Beesems, Steffie, additional, Correia, Vitor H., additional, Cimpoesu, Diana, additional, Burkart, Roman, additional, Booth, Scott, additional, Baubin, Michael, additional, Schinnerl, Adolf, additional, Prause, Gerhard, additional, Tschoellitsch, Thomas, additional, Trimmel, Helmut, additional, Belz, Rene, additional, Fleischmann, Wolfgang, additional, Bartiaux, Magali, additional, Monsieurs, Koenraad, additional, Wilmin, Stephan, additional, Faniel, Mathias, additional, Vanhove, Marie, additional, Lievens, Pascale, additional, Biarent, Dominique, additional, Van Nuffelen, Marc, additional, Hubloue, Ives, additional, Jacques, Jean-Marie, additional, Yerna, Michèle, additional, Leach, Robert, additional, Jeanmaire, Mathieu, additional, Denoël, Paule, additional, Van Trimpont, Frank, additional, Desmet, Francis, additional, Delhaye, Louise, additional, Van Belleghem, Vincent, additional, Dewitte, Ken, additional, Abbasi, Musa, additional, Scheyltjens, Simon, additional, Vermylen, Olivier, additional, de Longueville, Diane, additional, Debaize, Stéphane, additional, Antičević, Silvija Hunyadi, additional, Keleuva, Slobodanka, additional, Lazarević, Milan, additional, Ujević, Radmila Majhen, additional, Šego, Gordana Antić, additional, Bardak, Branka, additional, Mišković, Domagoj, additional, Praunová, Monika, additional, Franěk, Ondřej, additional, Kratochvíl, Jaroslav, additional, Přikryl, Jan, additional, Sýkora, Roman, additional, Vaňatka, Tomáš, additional, Vašák, Marek, additional, Jaššo, Petr, additional, Šmejkal, Petr, additional, Kušička, Otomar, additional, Šín, Robin, additional, Smržová, Eva, additional, Pfeifer, Dorián, additional, Harve-Rytsälä, Heini, additional, Hiltunen, Pamela, additional, Holmström, Peter, additional, Iirola, Timo, additional, Jokela, Katja, additional, Kirves, Hetti, additional, Korvenoja, Pekka, additional, Kuisma, Markku, additional, Laine, Jukka, additional, Lyyra, Markus, additional, Länkimäki, Sami, additional, Portaankorva, Petra, additional, Raatiniemi, Lasse, additional, Sainio, Marko, additional, Setälä, Piritta, additional, Toivonen, Tuukka, additional, Uotinen, Jan, additional, Vaahersalo, Jukka, additional, Väyrynen, Taneli, additional, Hamdan, David, additional, Agostinucci, Jean-Marc, additional, Branche, Fabienne, additional, Revaux, François, additional, Jonquet, Sébastien, additional, Loubert, Richard, additional, Boursier, Marion, additional, Simonnet, Bruno, additional, Morel, Jean-Charles, additional, Lagadec, Steven, additional, Avondo, Aurélie, additional, Gelin, Emilie, additional, Morel-Maréchal, Emanuel, additional, Ursat, Cécile, additional, Villain-Coquet, Laurent, additional, Fournier, Marc, additional, Tabary, Romain, additional, Le Pimpec, Philippe, additional, Hugenschmitt, Delphine, additional, Abarrategui, Diego, additional, Blondet, Romain, additional, Arnaud, Aurélie, additional, Sadoune, Sonia, additional, Segard, Julien, additional, Narcisse, Sophie, additional, Laot, Mélanie, additional, Pernot, Thomas, additional, Courcoux, Hubert, additional, Chassin, Coralie, additional, Jardel, Benoît, additional, Picart, Jeanne, additional, Brèche, Franck Garden, additional, Guenier, Pierre-Alban, additional, Getti, Renaud, additional, Jeziorny, Alexandre, additional, Leroy, Antoine, additional, Vanderstraeten, Carine, additional, Dussoulier, Sébastien, additional, Haja, Attila, additional, Németh, Dániel, additional, Válint, Andrea, additional, Csató, Gábor, additional, Lóczi, Gerda, additional, Vörös, Péter, additional, Németh, Zsuzsanna, additional, Molnár, Ferenc, additional, Nagy, Ferenc, additional, Kádár, Henrietta, additional, Duda, Julia, additional, Tęczar, Justyna, additional, Dul, Sylwia, additional, Świtacz, Grażyna, additional, Raczynski, Andrzej, additional, Fiser, Zlatko, additional, Babic, Zlatko, additional, Opacic, Aleksandra, additional, Horvat, Kornelija Jaksic, additional, Vukelic, Snezana, additional, Tijanic, Jelena, additional, Milenkovic, Dusan, additional, Milic, Sasa, additional, Babinski, Deze, additional, Boskovic, Cedomir, additional, Koprivica, Jovanka, additional, Terek, Erika, additional, Provci, Goran, additional, Zvijer, Dragana Jovic, additional, Bajerovská, Ľubica, additional, Chabroň, Miroslav, additional, Pražienková, Danka, additional, Kratochvílová, Renáta, additional, Burian, Radoslav, additional, Dobrík, Martin, additional, Patráš, Juraj, additional, Šteflík, Vladimír, additional, Androvič, Peter, additional, Mičáň, František, additional, Horáňová, Božena, additional, Pavčo, Július, additional, Grochová, Monika, additional, Bulíková, Táňa, additional, Maček, Rok, additional, Furman, Matej Rubelli, additional, Podhostnik, Samo, additional, Oman, Miha, additional, Lipovšek, Klemen, additional, Baznik, Špela, additional, Ferenčina, Jurica, additional, Strnad, Matej, additional, Žižek, Edith, additional, Kodela, Miha, additional, Košat, Alenka Antolinc, additional, Lotrič, Nina, additional, Lindqvist, Jonny, additional, Stieglis, Remy, additional, and Radstok, Anja, additional

Published
2021
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33. Acute bronchiolitis: Why put an IV line?

Author

Redant, Sébastien, primary, Nehar-Stern, Nora, additional, Honoré, Patrick M., additional, Attou, Rachid, additional, Haggenmacher, Caroline, additional, Tolwani, Ashita, additional, De Bels, David, additional, and Biarent, Dominique, additional

Published
2021
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34. European Resuscitation Council Guidelines 2021: Paediatric Life Support

Author

Van de Voorde, Patrick, Turner, Nigel Mc Beth N.M., Djakow, Jana, de Lucas, Nieves, Martinez-Mejias, Abel, Biarent, Dominique, Bingham, Robert, Brissaud, Olivier, Hoffmann, Florian, Johannesdottir, Groa Bjork, Lauritsen, Torsten, MacOnochie, Ian, Van de Voorde, Patrick, Turner, Nigel Mc Beth N.M., Djakow, Jana, de Lucas, Nieves, Martinez-Mejias, Abel, Biarent, Dominique, Bingham, Robert, Brissaud, Olivier, Hoffmann, Florian, Johannesdottir, Groa Bjork, Lauritsen, Torsten, and MacOnochie, Ian

Abstract

These European Resuscitation Council Paediatric Life Support (PLS) guidelines, are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. This section provides guidelines on the management of critically ill infants and children, before, during and after cardiac arrest., SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2021

35. Increasing burden of viral bronchiolitis in the pediatric intensive care unit; an observational study

Author

Linssen, Rosalie R.S., Teirlinck, Anne A.C., van Boven, Michiel, Biarent, Dominique, Stona, Luca, Amigoni, Angela, Comoretto, Rosanna Irene, Leteurtre, Stéphane, Bruandet, Amélie, Bentsen, Gunnar G.K., Drage, Inger Marie, Wang, Xin, Campbell, Harry, van Woensel, Job J.B.M., Bont, Louis, Bem, Reinout R.A., Linssen, Rosalie R.S., Teirlinck, Anne A.C., van Boven, Michiel, Biarent, Dominique, Stona, Luca, Amigoni, Angela, Comoretto, Rosanna Irene, Leteurtre, Stéphane, Bruandet, Amélie, Bentsen, Gunnar G.K., Drage, Inger Marie, Wang, Xin, Campbell, Harry, van Woensel, Job J.B.M., Bont, Louis, and Bem, Reinout R.A.

Abstract

Purpose: Viral bronchiolitis is a major cause of pediatric intensive care unit (PICU) admission. Insight in the trends of bronchiolitis-associated PICU admissions is limited, but imperative for future PICU resource and capacity planning. Materials and methods: We retrospectively studied trends in PICU admissions for bronchiolitis in six European sites, including three full national registries, between 2000 and 2019 and calculated population-based estimates per 100,000 children where appropriate. Information concerning risk factors for severe disease and use of invasive mechanical ventilation was also collected when available. Results: In total, there were 15,606 PICU admissions for bronchiolitis. We observed an increase in the annual number, rate and estimates per 100,000 children of PICU admissions for bronchiolitis at all sites over the last two decades, while the proportion of patients at high risk for severe disease remained relatively stable. Conclusions: The international increased burden of bronchiolitis for the PICU is concerning, and warrants further international attention and investigation., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

37. European Resuscitation Council Guidelines 2021: Paediatric Life Support

Author

Van de Voorde, Patrick, primary, Turner, Nigel M., additional, Djakow, Jana, additional, de Lucas, Nieves, additional, Martinez-Mejias, Abel, additional, Biarent, Dominique, additional, Bingham, Robert, additional, Brissaud, Olivier, additional, Hoffmann, Florian, additional, Johannesdottir, Groa Bjork, additional, Lauritsen, Torsten, additional, and Maconochie, Ian, additional

Published
2021
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38. Impact of CRRT in Patients with PARDS Treated with VV-ECMO

Author

Redant, Sébastien, primary, Barbance, Océane, additional, Tolwani, Ashita, additional, Beretta-Piccoli, Xavier, additional, Massaut, Jacques, additional, De Bels, David, additional, Taccone, Fabio S., additional, Honoré, Patrick M., additional, and Biarent, Dominique, additional

Published
2021
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39. Transfusion strategies for patients in pediatric intensive care units

Author

Lacroix, Jacques, Hebert, Paul C., Hutchison, James S., Hume, Heather A., Tucci, Marisa, Ducruet, Thierry, Gauvin, France, Collet, Jean-Paul, Tolendano, Baruch J., Robillard, Pierre, Joffe, Ari, Biarent, Dominique, Meert, Kathleen, and Peters, Mark J.

Subjects
Pediatric intensive care -- Research, Blood transfusion -- Research, Critically ill children -- Care and treatment
Abstract

A noninferiority trial was conducted on 637 stable, severely ill children with hemoglobin concentration less than 9.5g per deciliter after being admitted in an intensive care unit for seven days to determine that a restrictive transfusion strategy of using packed red cells that were leukocyte-reduced before storage is as safe as a liberal transfusion strategy. It was inferred that the transfusion requirements were reduced without increasing adverse results in children with a hemoglobin threshold of 7 g per deciliter for red-cell transfusion.

Published
2007

40. Central Sleep Apnea Syndrome Can Complicate Neuromyelitis Optica Spectrum Disorder: A Case Report

Author

Morelli, Céline, Aeby, Alec, Scaillet, Sonia, Boitsios, Grammatina, Vens, Daphné, Prigogine, Cynthia, Biarent, Dominique, Vicinanza, Alfredo, Morelli, Céline, Aeby, Alec, Scaillet, Sonia, Boitsios, Grammatina, Vens, Daphné, Prigogine, Cynthia, Biarent, Dominique, and Vicinanza, Alfredo

Abstract

Neuromyelitis optica spectrum disorder is a rare, relapsing autoimmune disease of the central nervous system. Various initial presentations can delay diagnosis and treatment. A 14-year-old girl was admitted to the emergency department owing to respiratory insufficiency. Repeated history-taking and neuroimaging revealed an area postrema syndrome. A diagnosis of neuromyelitis optica spectrum disorder with positive aquaporin-4 antibodies has finally been established. The patient improved significantly with immunosuppressive therapy. However, her 3-year follow-up still showed sleep-disordered breathing requiring nocturnal bilevel positive airway pressure therapy. We report an original case of NMOSD leading to persistent central sleep apnea syndrome., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

45. Pediatric Life Support

Author

Maconochie, Ian K., primary, Aickin, Richard, additional, Hazinski, Mary Fran, additional, Atkins, Dianne L., additional, Bingham, Robert, additional, Couto, Thomaz Bittencourt, additional, Guerguerian, Anne-Marie, additional, Nadkarni, Vinay M., additional, Ng, Kee-Chong, additional, Nuthall, Gabrielle A., additional, Ong, Gene Y.K., additional, Reis, Amelia G., additional, Schexnayder, Stephen M., additional, Scholefield, Barnaby R., additional, Tijssen, Janice A., additional, Nolan, Jerry P., additional, Morley, Peter T., additional, Van de Voorde, Patrick, additional, Zaritsky, Arno L., additional, de Caen, Allan R., additional, Moylan, Alex, additional, Topjian, Alexis, additional, Nation, Kevin, additional, Ohshimo, Shinchiro, additional, Bronicki, Ronald A., additional, Kadlec, Kelly D., additional, Knight, Lynda J., additional, McCormick, Taylor N., additional, Morgan, Ryan W., additional, Roberts, Joan S., additional, Tabbutt, Sarah, additional, Thiagarajan, Ravi, additional, Walsh, Brian, additional, Raymond, Tia, additional, Chan, Melissa, additional, Duff, Jonathan P., additional, Joyner, Benny L., additional, Lasa, Javier J., additional, Levy, Arielle, additional, Roberts, Kathryn E., additional, Sutton, Robert M., additional, de Lucas, Nieves, additional, Hoffmann, Florian, additional, Turner, Nigel, additional, Biarent, Dominique, additional, Lauritsen, Torsten, additional, Brissaud, Olivier, additional, Johannesdottir, Groa, additional, Djakow, Jana, additional, Mejias, Abel Martinez, additional, and Meckler, Garth, additional

Published
2020
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46. Pediatric Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

Author

Maconochie, Ian K., primary, Aickin, Richard, additional, Hazinski, Mary Fran, additional, Atkins, Dianne L., additional, Bingham, Robert, additional, Couto, Thomaz Bittencourt, additional, Guerguerian, Anne-Marie, additional, Nadkarni, Vinay M., additional, Ng, Kee-Chong, additional, Nuthall, Gabrielle A., additional, Ong, Gene Y.K., additional, Reis, Amelia G., additional, Schexnayder, Stephen M., additional, Scholefield, Barnaby R., additional, Tijssen, Janice A., additional, Nolan, Jerry P., additional, Morley, Peter T., additional, Van de Voorde, Patrick, additional, Zaritsky, Arno L., additional, de Caen, Allan R., additional, Moylan, Alex, additional, Topjian, Alexis, additional, Nation, Kevin, additional, Ohshimo, Shinchiro, additional, Bronicki, Ronald A., additional, Kadlec, Kelly D., additional, Knight, Lynda J., additional, McCormick, Taylor N., additional, Morgan, Ryan W., additional, Roberts, Joan S., additional, Tabbutt, Sarah, additional, Thiagarajan, Ravi, additional, Walsh, Brian, additional, Raymond, Tia, additional, Chan, Melissa, additional, Duff, Jonathan P., additional, Joyner, Benny L., additional, Lasa, Javier J., additional, Levy, Arielle, additional, Roberts, Kathryn E., additional, Sutton, Robert M., additional, de Lucas, Nieves, additional, Hoffmann, Florian, additional, Turner, Nigel, additional, Biarent, Dominique, additional, Lauritsen, Torsten, additional, Brissaud, Olivier, additional, Johannesdottir, Groa, additional, Djakow, Jana, additional, Mejias, Abel Martinez, additional, Meckler, Garth, additional, Buchanan, Matt, additional, and Morrison, Laurie J., additional

Published
2020
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50. Shoshin Beriberi and severe accidental hypothermia as causes of heart failure in a 6-year-old child: A case report and brief review of literature

Author

Vicinanza, Alfredo, De Laet, Corinne, Rooze, Shancy, Willems, Ariane, Beretta-Piccoli, Xavier, Vens, Daphné, Voglet, Cédric, Jacquemart, Caroline, Massin, Martial, Biarent, Dominique, Vicinanza, Alfredo, De Laet, Corinne, Rooze, Shancy, Willems, Ariane, Beretta-Piccoli, Xavier, Vens, Daphné, Voglet, Cédric, Jacquemart, Caroline, Massin, Martial, and Biarent, Dominique

Abstract

Severe accidental hypothermia has been demonstrated to affect ventricular systolic and diastolic functions, and rewarming might be responsible of cardiovascular collapse. Until now, there have been only a few reports on severe accidental hypothermia, none of which involved children. Herein, we describe here a rare case of heart failure in a 6-year-old boy admitted to the emergency unit owing to severe hypothermia and malnutrition. After he was warmed up (core temperature of 27.2°C at admission), he developed cardiac arrest, requiring vasoactive amines administration, and veno-arterial extracorporeal membrane oxygenation. Malnutrition and refeeding syndrome might have caused the thiamine deficiency, commonly known as beriberi, which contributed to heart failure as well. He showed remarkable improvement in heart failure symptoms after thiamine supplementation. High-dose supplementation per os (500 mg/day) after reconstitution of an adequate electrolyte balance enabled the patient to recover completely within 2 weeks, even if a mild diastolic cardiac dysfunction persisted longer. In conclusion, we describe an original pediatric case of heart failure due to overlap of severe accidental hypothermia with rewarming, malnutrition, and refeeding syndrome with thiamine deficiency, which are rare independent causes of cardiac dysfunction. The possibility of beriberi as a cause of heart failure and adequate thiamine supplementation should be considered in all high-risk patients, especially those with malnutrition. Refeeding syndrome requires careful management, including gradual electrolyte imbalance correction and administration of a thiamine loading dose to prevent or correct refeeding-induced thiamine deficiency., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2019

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