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132 results on '"Bienvenu, O. J."'

1. Reporting the early stage clinical evaluation of virtual-reality-based intervention trials: RATE-VR

Author

Vlake, J. H., van Bommel, J., Riva, Giuseppe, Wiederhold, B. K., Cipresso, Pietro, Rizzo, A. S., Botella, C., Hooft, L., Bienvenu, O. J., Geerts, B., Wils, E. -J., Gommers, D., van Genderen, M. E., Riva G. (ORCID:0000-0003-3657-106X), Cipresso P. (ORCID:0000-0002-0662-7678), Vlake, J. H., van Bommel, J., Riva, Giuseppe, Wiederhold, B. K., Cipresso, Pietro, Rizzo, A. S., Botella, C., Hooft, L., Bienvenu, O. J., Geerts, B., Wils, E. -J., Gommers, D., van Genderen, M. E., Riva G. (ORCID:0000-0003-3657-106X), and Cipresso P. (ORCID:0000-0002-0662-7678)

Abstract

Virtual reality (VR) is rapidly emerging as an impactful healthcare technology1. As with artificial intelligence (AI) algorithms, the number of VR-based studies and applications is growing exponentially, and the US Food and Drug Administration recently approved a medical extended reality program. VR has recently made substantial technological progress, particularly in terms of simulation capacities, and it is expected that this ongoing development will eventually result in preventive or therapeutic interventions for mental health disorders, pain management, surgical simulation and perioperative management. We make the case for an easy and practical reporting standard for early and small-scale clinical evaluation, between the preclinical technological development of VR and the design of large-scale clinical VR intervention trials. Because a comprehensive guideline for the standardization of clinical VR is necessary to avoid preventable harm and research waste, we are initiating a Delphi process with strong stakeholder engagement to reach expert consensus on adequate and transparent reporting under the name: ‘Reporting guideline and quality criteria for the early-stage clinical evaluation of virtual-reality-based intervention trials: RATE-VR’. Despite our focus on VR, this guideline will also be applicable to other emerging extended reality (XR) technologies, including augmented reality and mixed reality, as the methodological, human factors and safety considerations are largely similar to VR.

Published
2023

2. Whole-genome association analysis of treatment response in obsessive-compulsive disorder

Author

Qin, H, Samuels, J F, Wang, Y, Zhu, Y, Grados, M A, Riddle, M A, Greenberg, B D, Knowles, J A, Fyer, A J, McCracken, J T, Murphy, D L, Rasmussen, S A, Cullen, B A, Piacentini, J, Geller, D, Stewart, S E, Pauls, D, Bienvenu, O J, Goes, F S, Maher, B, Pulver, A E, Valle, D, Lange, C, Mattheisen, M, McLaughlin, N C, Liang, K-Y, Nurmi, E L, Askland, K D, Nestadt, G, and Shugart, Y Y

Published
2016
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3. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS

Author

Mattheisen, M, Samuels, J F, Wang, Y, Greenberg, B D, Fyer, A J, McCracken, J T, Geller, D A, Murphy, D L, Knowles, J A, Grados, M A, Riddle, M A, Rasmussen, S A, McLaughlin, N C, Nurmi, E L, Askland, K D, Qin, H-D, Cullen, B A, Piacentini, J, Pauls, D L, Bienvenu, O J, Stewart, S E, Liang, K-Y, Goes, F S, Maher, B, Pulver, A E, Shugart, Y Y, Valle, D, Lange, C, and Nestadt, G

Published
2015
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4. Genome-wide association study of obsessive-compulsive disorder

Author

Stewart, S E, Yu, D, Scharf, J M, Neale, B M, Fagerness, J A, Mathews, C A, Arnold, P D, Evans, P D, Gamazon, E R, Osiecki, L, McGrath, L, Haddad, S, Crane, J, Hezel, D, Illman, C, Mayerfeld, C, Konkashbaev, A, Liu, C, Pluzhnikov, A, Tikhomirov, A, Edlund, C K, Rauch, S L, Moessner, R, Falkai, P, Maier, W, Ruhrmann, S, Grabe, H-J, Lennertz, L, Wagner, M, Bellodi, L, Cavallini, M C, Richter, M A, Cook, Jr, E H, Kennedy, J L, Rosenberg, D, Stein, D J, Hemmings, S M J, Lochner, C, Azzam, A, Chavira, D A, Fournier, E, Garrido, H, Sheppard, B, Umaña, P, Murphy, D L, Wendland, J R, Veenstra-VanderWeele, J, Denys, D, Blom, R, Deforce, D, Van Nieuwerburgh, F, Westenberg, H G M, Walitza, S, Egberts, K, Renner, T, Miguel, E C, Cappi, C, Hounie, A G, Conceição do Rosário, M, Sampaio, A S, Vallada, H, Nicolini, H, Lanzagorta, N, Camarena, B, Delorme, R, Leboyer, M, Pato, C N, Pato, M T, Voyiaziakis, E, Heutink, P, Cath, D C, Posthuma, D, Smit, J H, Samuels, J, Bienvenu, O J, Cullen, B, Fyer, A J, Grados, M A, Greenberg, B D, McCracken, J T, Riddle, M A, Wang, Y, Coric, V, Leckman, J F, Bloch, M, Pittenger, C, Eapen, V, Black, D W, Ophoff, R A, Strengman, E, Cusi, D, Turiel, M, Frau, F, Macciardi, F, Gibbs, J R, Cookson, M R, Singleton, A, Hardy, J, Crenshaw, A T, Parkin, M A, Mirel, D B, Conti, D V, Purcell, S, Nestadt, G, Hanna, G L, Jenike, M A, Knowles, J A, Cox, N, and Pauls, D L

Published
2013
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8. Meta-analysis of association between obsessive-compulsive disorder and the 3′ region of neuronal glutamate transporter gene SLC1A1

Author

Stewart, S. E., Mayerfeld, C., Arnold, P. D., Crane, J. R., OʼDushlaine, C., Fagerness, J. A., Yu, D., Scharf, J. M., Chan, E., Kassam, F., Moya, P. R., Wendland, J. R., Delorme, R., Richter, M. A., Kennedy, J. L., Veenstra-VanderWeele, J., Samuels, J., Greenberg, B. D., McCracken, J. T., Knowles, J. A., Fyer, A. J., Rauch, S. L., Riddle, M. A., Grados, M. A., Bienvenu, O. J., Cullen, B., Wang, Y., Shugart, Y. Y., Piacentini, J., Rasmussen, S., Nestadt, G., Murphy, D. L., Jenike, M. A., Cook, E. H., Pauls, D. L., Hanna, G. L., and Mathews, C. A.

Published
2013
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12. Homeobox genes in obsessive-compulsive disorder

Author

Nestadt, G., Wang, Y., Grados, M. A., Riddle, M. A., Greenberg, B. D., Knowles, J. A., Fyer, A. J., McCracken, J. T., Rauch, S. L., Murphy, D. L., Rasmussen, S. A., Cullen, B., Piacentini, J., Geller, D., Pauls, D., Bienvenu, O. J., Chen, Y., Liang, K. Y., Goes, F. S., Maher, B., Pulver, A. E., Shugart, Y. Y., Valle, D., Samuels, J. F., and Chang, Y. C.

Published
2012
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15. Obsessive—compulsive disorder: subclassification based on co-morbidity

Author

Nestadt, G., Di, C. Z., Riddle, M. A., Grados, M. A., Greenberg, B. D., Fyer, A. J., McCracken, J. T., Rauch, S. L., Murphy, D. L., Rasmussen, S. A., Cullen, B., Pinto, A., Knowles, J. A., Piacentini, J., Pauls, D. L., Bienvenu, O. J., Wang, Y., Liang, K. Y., Samuels, J. F., and Roche, K. Bandeen

Published
2009

22. Erratum: Genome-wide association study of obsessive-compulsive disorder

Author

Stewart, S E, Yu, D, Scharf, J M, Neale, B M, Fagerness, J A, Mathews, C A, Arnold, P D, Evans, P D, Gamazon, E R, Osiecki, L, McGrath, L, Haddad, S, Crane, J, Hezel, D, Illman, C, Mayerfeld, C, Konkashbaev, A, Liu, C, Pluzhnikov, A, Tikhomirov, A, Edlund, C K, Rauch, S L, Moessner, R, Falkai, P, Maier, W, Ruhrmann, S, Grabe, H-J, Lennertz, L, Wagner, M, Bellodi, L, Cavallini, M C, Richter, M A, Cook, Jr, E H, Kennedy, J L, Rosenberg, D, Stein, D J, Hemmings, S M J, Lochner, C, Azzam, A, Chavira, D A, Fournier, E, Garrido, H, Sheppard, B, Umaña, P, Murphy, D L, Wendland, J R, Veenstra-Vander Weele, J, Denys, D, Blom, R, Deforce, D, Van Nieuwerburgh, F, Westenberg, H G M, Walitza, S, Egberts, K, Renner, T, Miguel, E C, Cappi, C, Hounie, A G, Conceição do Rosário, M, Sampaio, A S, Vallada, H, Nicolini, H, Lanzagorta, N, Camarena, B, Delorme, R, Leboyer, M, Pato, C N, Pato, M T, Voyiaziakis, E, Heutink, P, Cath, D C, Posthuma, D, Smit, J H, Samuels, J, Bienvenu, O J, Cullen, B, Fyer, A J, Grados, M A, Greenberg, B D, McCracken, J T, Riddle, M A, Wang, Y, Coric, V, Leckman, J F, Bloch, M, Pittenger, C, Eapen, V, Black, D W, Ophoff, R A, Strengman, E, Cusi, D, Turiel, M, Frau, F, Macciardi, F, Gibbs, J R, Cookson, M R, Singleton, A, Hardy, J, Crenshaw, A T, Parkin, M A, Mirel, D B, Conti, D V, Purcell, S, Nestadt, G, Hanna, G L, Jenike, M A, Knowles, J A, Cox, N, and Pauls, D L

Published
2013
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24. Dependent personality, separation anxiety disorder and other anxiety disorders in OCD

Author

Mroczkowski, M. M., primary, Goes, F. S., additional, Riddle, M. A., additional, Grados, M. A., additional, Bienvenu, O. J., additional, Greenberg, B. D., additional, Fyer, A. J., additional, McCracken, J. T., additional, Rauch, S. L., additional, Murphy, D. L., additional, Knowles, J. A., additional, Piacentini, J., additional, Cullen, B., additional, Rasmussen, S. A., additional, Pauls, D. L., additional, Nestadt, G., additional, and Samuels, J., additional

Published
2015
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25. Whole-genome association analysis of treatment response in obsessive-compulsive disorder

Author

Qin, H, primary, Samuels, J F, additional, Wang, Y, additional, Zhu, Y, additional, Grados, M A, additional, Riddle, M A, additional, Greenberg, B D, additional, Knowles, J A, additional, Fyer, A J, additional, McCracken, J T, additional, Murphy, D L, additional, Rasmussen, S A, additional, Cullen, B A, additional, Piacentini, J, additional, Geller, D, additional, Stewart, S E, additional, Pauls, D, additional, Bienvenu, O J, additional, Goes, F S, additional, Maher, B, additional, Pulver, A E, additional, Valle, D, additional, Lange, C, additional, Mattheisen, M, additional, McLaughlin, N C, additional, Liang, K-Y, additional, Nurmi, E L, additional, Askland, K D, additional, Nestadt, G, additional, and Shugart, Y Y, additional

Published
2015
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26. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS

Author

Mattheisen, M, primary, Samuels, J F, additional, Wang, Y, additional, Greenberg, B D, additional, Fyer, A J, additional, McCracken, J T, additional, Geller, D A, additional, Murphy, D L, additional, Knowles, J A, additional, Grados, M A, additional, Riddle, M A, additional, Rasmussen, S A, additional, McLaughlin, N C, additional, Nurmi, E L, additional, Askland, K D, additional, Qin, H-D, additional, Cullen, B A, additional, Piacentini, J, additional, Pauls, D L, additional, Bienvenu, O J, additional, Stewart, S E, additional, Liang, K-Y, additional, Goes, F S, additional, Maher, B, additional, Pulver, A E, additional, Shugart, Y Y, additional, Valle, D, additional, Lange, C, additional, and Nestadt, G, additional

Published
2014
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27. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

Author

Davis, L. K., Yu, D., Keenan, C. L., Gamazon, E. R., Konkashbaev, A. I., Derks, E. M., Neale, B. M., Yang, J., Lee, S. H., Evans, P., Barr, C. L., Bellodi, L., Benarroch, F., Berrio, G. B., Bienvenu, O. J., Bloch, M. H., Blom, R. M., Bruun, R. D., Budman, C. L., Camarena, B., Campbell, D., Cappi, C., Cardona Silgado, J. C., Cath, D. C., Cavallini, M. C., Chavira, D. A., Chouinard, S., Conti, D. V., Cook, E. H., Coric, V., Cullen, B. A., Deforce, D., Delorme, R., Dion, Y., Edlund, C. K., Egberts, K., Falkai, P., Fernandez, T. V., Gallagher, P. J., Garrido, H., Geller, D., Girard, Simon, Grabe, H. J., Grados, M. A., Greenberg, B. D., Gross-Tsur, V., Haddad, S., Heiman, G. A., Hemmings, S. M.J., Hounie, A. G., Illmann, C., Jankovic, J., Jenike, M. A., Kennedy, J. L., King, R. A., Kremeyer, B., Kurlan, R., Lanzagorta, N., Leboyer, M., Leckman, J. F., Lennertz, L., Liu, C., Lochner, C., Lowe, T. L., Macciardi, F., McCracken, J. T., McGrath, L. M., Mesa Restrepo, S. C., Moessner, R., Morgan, J., Muller, H., Murphy, D. L., Naarden, A. L., Ochoa, W. C., Ophoff, R. A., Osiecki, L., Pakstis, A. J., Pato, M. T., Pato, C. N., Piacentini, J., Pittenger, C., Pollak, Y., Rauch, S. L., Renner, T. J., Reus, V. I., Richter, M. A., Riddle, M. A., Robertson, M. M., Romero, R., Rosario, M. C., Rosenberg, D., Rouleau, G. A., Ruhrmann, S., Ruiz-Linares, A., Sampaio, A. S., Samuels, J., Sandor, P., Sheppard, B., Singer, H. S., Smit, J. H., Stein, D. J., Strengman, E., Tischfield, J. A., Valencia Duarte, A. V., Vallada, H., Van Nieuwerburgh, F., Veenstra-Vanderweele, J., Walitza, S., Wang, Y., Wendland, J. R., Westenberg, H. G.M., Shugart, Y. Y., Miguel, E. C., McMahon, W., Wagner, M., Nicolini, H., Posthuma, D., Hanna, G. L., Heutink, P., Denys, D., Arnold, P. D., Oostra, B. A., Nestadt, G., Freimer, N. B., Pauls, D. L., Wray, N. R., Stewart, S. E., Mathews, C. A., Knowles, J. A., Cox, N. J., Scharf, J. M., Davis, L. K., Yu, D., Keenan, C. L., Gamazon, E. R., Konkashbaev, A. I., Derks, E. M., Neale, B. M., Yang, J., Lee, S. H., Evans, P., Barr, C. L., Bellodi, L., Benarroch, F., Berrio, G. B., Bienvenu, O. J., Bloch, M. H., Blom, R. M., Bruun, R. D., Budman, C. L., Camarena, B., Campbell, D., Cappi, C., Cardona Silgado, J. C., Cath, D. C., Cavallini, M. C., Chavira, D. A., Chouinard, S., Conti, D. V., Cook, E. H., Coric, V., Cullen, B. A., Deforce, D., Delorme, R., Dion, Y., Edlund, C. K., Egberts, K., Falkai, P., Fernandez, T. V., Gallagher, P. J., Garrido, H., Geller, D., Girard, Simon, Grabe, H. J., Grados, M. A., Greenberg, B. D., Gross-Tsur, V., Haddad, S., Heiman, G. A., Hemmings, S. M.J., Hounie, A. G., Illmann, C., Jankovic, J., Jenike, M. A., Kennedy, J. L., King, R. A., Kremeyer, B., Kurlan, R., Lanzagorta, N., Leboyer, M., Leckman, J. F., Lennertz, L., Liu, C., Lochner, C., Lowe, T. L., Macciardi, F., McCracken, J. T., McGrath, L. M., Mesa Restrepo, S. C., Moessner, R., Morgan, J., Muller, H., Murphy, D. L., Naarden, A. L., Ochoa, W. C., Ophoff, R. A., Osiecki, L., Pakstis, A. J., Pato, M. T., Pato, C. N., Piacentini, J., Pittenger, C., Pollak, Y., Rauch, S. L., Renner, T. J., Reus, V. I., Richter, M. A., Riddle, M. A., Robertson, M. M., Romero, R., Rosario, M. C., Rosenberg, D., Rouleau, G. A., Ruhrmann, S., Ruiz-Linares, A., Sampaio, A. S., Samuels, J., Sandor, P., Sheppard, B., Singer, H. S., Smit, J. H., Stein, D. J., Strengman, E., Tischfield, J. A., Valencia Duarte, A. V., Vallada, H., Van Nieuwerburgh, F., Veenstra-Vanderweele, J., Walitza, S., Wang, Y., Wendland, J. R., Westenberg, H. G.M., Shugart, Y. Y., Miguel, E. C., McMahon, W., Wagner, M., Nicolini, H., Posthuma, D., Hanna, G. L., Heutink, P., Denys, D., Arnold, P. D., Oostra, B. A., Nestadt, G., Freimer, N. B., Pauls, D. L., Wray, N. R., Stewart, S. E., Mathews, C. A., Knowles, J. A., Cox, N. J., and Scharf, J. M.

Abstract

The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quantified the variance in liability to disease explained by all SNPs for two phenotypically-related neurobehavioral disorders, obsessive-compulsive disorder (OCD) and Tourette Syndrome (TS), using GCTA. Our analysis yielded a heritability point estimate of 0.58 (se = 0.09, p = 5.64e-12) for TS, and 0.37 (se = 0.07, p = 1.5e-07) for OCD. In addition, we conducted multiple genomic partitioning analyses to identify genomic elements that concentrate this heritability. We examined genomic architectures of TS and OCD by chromosome, MAF bin, and functional annotations. In addition, we assessed heritability for early onset and adult onset OCD. Among other notable results, we found that SNPs with a minor allele frequency of less than 5% accounted for 21% of the TS heritability and 0% of the OCD heritability. Additionally, we identified a significant contribution to TS and OCD heritability by variants significantly associated with gene expression in two regions of the brain (parietal cortex and cerebellum) for which we had available expression quantitative trait loci (eQTLs). Finally we analyzed the genetic correlation between TS and OCD, revealing a genetic correlation of 0.41 (se = 0.15, p = 0.002). These results are very close to previous heritability estimates for TS and OCD based on twin and family studies, suggesting that very little, if any, heritability is truly missing (i.e., unassayed) from TS and OCD GWAS studies of common variation. The results also indicate that there is some genetic overlap between these two phenotypically-related neuropsychiatric disorders, but suggest that the two disorders have distinct genetic architectures.

Published
2013

29. Dependent personality, separation anxiety disorder and other anxiety disorders in OCD.

Author

Mroczkowski, M. M., Goes, F. S., Riddle, M. A., Grados, M. A., Bienvenu, O. J., Greenberg, B. D., Fyer, A. J., McCracken, J. T., Rauch, S. L., Murphy, D. L., Knowles, J. A., Piacentini, J., Cullen, B., Rasmussen, S. A., Pauls, D. L., Nestadt, G., and Samuels, J.

Subjects
AGE factors in disease, DEPENDENCY (Psychology), INTERVIEWING, OBSESSIVE-compulsive disorder, PERSONALITY assessment, PERSONALITY disorders, SEPARATION anxiety, LOGISTIC regression analysis, SEVERITY of illness index
Abstract

Background: The purpose of this study was to investigate whether dependent personality and/or general personality dimensions might explain the strong relationships between separation anxiety disorder (Sep‐AD) and three other anxiety disorders (agoraphobia, panic disorder and social anxiety disorder) in individuals with obsessive compulsive disorder (OCD). Methods: Using data from 509 adult participants collected during the OCD Collaborative Genetic Study, we used logistic regression models to evaluate the relationships between Sep‐AD, dependent personality score, general personality dimensions and three additional anxiety disorders. Results: The dependent personality score was strongly associated with Sep‐AD and the other anxiety disorders in models adjusted for age at interview, age at onset of OC symptoms and worst ever OCD severity score. Several general personality dimensions, especially neuroticism, extraversion and conscientiousness, were also related to Sep‐AD and the other anxiety disorders. Sep‐AD was not independently related to these anxiety disorders, in multivariate models including general personality and dependent personality disorder scores. Conclusions: The results suggest that Sep‐AD in childhood and these other anxiety disorders in adulthood are consequences of dependent personality disorder (for agoraphobia and panic disorder) or introversion (for social phobia). It is unknown whether these results would be similar in a non‐OCD sample. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2016
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30. Delirium/Coma-Free Days Improve With An ICU Sleep Quality Improvement Project

Author

Kamdar, Biren B., primary, King, Lauren M., additional, Sakamuri, Sruthi, additional, Touradji, Pegah, additional, Colantuoni, Elizabeth, additional, Neufeld, Karin J., additional, Bienvenu, O J., additional, Rowden, Annette M., additional, Le, Amanda B., additional, Shah, Pooja A., additional, Nandkumar, Preeya, additional, Christie, Melinda, additional, Rahman, Farah, additional, Collop, Nancy A., additional, and Needham, Dale M., additional

Published
2012
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32. Is obsessive–compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective

Author

Bienvenu, O. J., primary, Samuels, J. F., additional, Wuyek, L. A., additional, Liang, K.-Y., additional, Wang, Y., additional, Grados, M. A., additional, Cullen, B. A., additional, Riddle, M. A., additional, Greenberg, B. D., additional, Rasmussen, S. A., additional, Fyer, A. J., additional, Pinto, A., additional, Rauch, S. L., additional, Pauls, D. L., additional, McCracken, J. T., additional, Piacentini, J., additional, Murphy, D. L., additional, Knowles, J. A., additional, and Nestadt, G., additional

Published
2011
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33. A Multi-Disciplinary Quality Improvement Project To Promote Sleep In The Icu

Author

Kamdar, Biren B., primary, King, Lauren M., additional, Neufeld, Karin J., additional, Bienvenu, O J., additional, Rowden, Annette M., additional, Touradji, Pegah, additional, Le, Amanda B., additional, Sakamuri, Sruthi, additional, Shah, Pooja A., additional, Nandkumar, Preeya, additional, Christie, Melinda R., additional, Rahman, Farah, additional, Collop, Nancy A., additional, and Needham, Dale M., additional

Published
2011
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35. Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study

Author

Voyiaziakis, E, primary, Evgrafov, O, additional, Li, D, additional, Yoon, H-J, additional, Tabares, P, additional, Samuels, J, additional, Wang, Y, additional, Riddle, M A, additional, Grados, M A, additional, Bienvenu, O J, additional, Shugart, Y Y, additional, Liang, K-Y, additional, Greenberg, B D, additional, Rasmussen, S A, additional, Murphy, D L, additional, Wendland, J R, additional, McCracken, J T, additional, Piacentini, J, additional, Rauch, S L, additional, Pauls, D L, additional, Nestadt, G, additional, Fyer, A J, additional, and Knowles, J A, additional

Published
2009
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36. Obsessive–compulsive disorder: subclassification based on co-morbidity

Author

Nestadt, G., primary, Di, C. Z., additional, Riddle, M. A., additional, Grados, M. A., additional, Greenberg, B. D., additional, Fyer, A. J., additional, McCracken, J. T., additional, Rauch, S. L., additional, Murphy, D. L., additional, Rasmussen, S. A., additional, Cullen, B., additional, Pinto, A., additional, Knowles, J. A., additional, Piacentini, J., additional, Pauls, D. L., additional, Bienvenu, O. J., additional, Wang, Y., additional, Liang, K. Y., additional, Samuels, J. F., additional, and Roche, K. Bandeen, additional

Published
2008
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37. The Burden of Mental Disorders

Author

Eaton, W. W., primary, Martins, S. S., additional, Nestadt, G., additional, Bienvenu, O. J., additional, Clarke, D., additional, and Alexandre, P., additional

Published
2008
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40. Authors' reply

Author

Bienvenu, O. J., primary, Onyike, C. U., additional, Stein, M. B., additional, Chen, L. S., additional, Samuels, J., additional, Nestadt, G., additional, and Eaton, W. W., additional

Published
2006
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42. OCD May Run in Families

Author

Nestadt, G., primary, Samuels, J., additional, Riddle, M., additional, Bienvenu, O. J., additional, Liang, K.-Y., additional, and LaBuda, M., additional

Published
2000
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44. Epidemiology of personality disorders.

Author

Sater, Nicola, Samuels, Jack, Bienvenu, O., Nestadt, Gerald, Sater, N, Samuels, J F, Bienvenu, O J, and Nestadt, G

Subjects
EPIDEMIOLOGICAL research, PERSONALITY disorders, COMORBIDITY, DISEASE incidence, DISEASE prevalence
Abstract

Epidemiology is concerned with the occurrence of disease in populations. Epidemiologic studies measure the prevalence and distribution of disorders, investigate questions of case definition, determine risk factors, and evaluate the natural history and consequences of disorders. This paper reviews and discusses empiric advances made over the past 2 years in the epidemiologic study of personality disorders. [ABSTRACT FROM AUTHOR]

Published
2001
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45. Personality disorders and normal personality dimensions in obsessive-compulsive disorder.

Author

Samuels, Jack, Nestadt, Gerald, Bienvenu, O. Joseph, Costa Jr., Paul T., Riddle, Mark A., Kung-Yee Liang, Hoehn-Saric, Rudolf, Grados, Marco A., Cullen, Bernadette A. M., Samuels, J, Nestadt, G, Bienvenu, O J, Costa, P T Jr, Riddle, M A, Liang, K Y, Hoehn-Saric, R, Grados, M A, and Cullen, B A

Subjects
PERSONALITY disorders, OBSESSIVE-compulsive disorder, PERSONALITY, PATIENTS, MEDICAL personnel, GENETIC disorders, RELATIVES, PERSONALITY tests, PSYCHOLOGY
Abstract

Background: Little is known about personality disorders and normal personality dimensions in relatives of patients with obsessive-compulsive disorder (OCD).Aims: To determine whether specific personality characteristics are part of a familial spectrum of OCD.Method: Clinicians evaluated personality disorders in 72 OCD case and 72 control probands and 198 case and 207 control first-degree relatives. The selfcompleted Revised NEO Personality Inventory was used for assessment of normal personality dimensions. The prevalence of personality disorders and scores on normal personality dimensions were compared between case and control probands and between case and control relatives.Results: Case probands and case relatives had a high prevalence of obsessive-compulsive personality disorder (OCPD) and high neuroticism scores. Neuroticism was associated with OCPD in case but not control relatives.Conclusions: Neuroticism and OCPD may share a common familial aetiology with OCD. [ABSTRACT FROM AUTHOR]

Published
2000
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