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14 results on '"Bierkandt, Frank S."'

2. Environmental considerations and current status of grouping and regulation of engineered nanomaterials

Author

Tschiche, Harald R., primary, Bierkandt, Frank S., additional, Creutzenberg, Otto, additional, Fessard, Valerie, additional, Franz, Roland, additional, Giese, Bernd, additional, Greiner, Ralf, additional, Haas, Karl‑Heinz, additional, Haase, Andrea, additional, Hartwig, Andrea, additional, Hund‑Rinke, Kerstin, additional, Iden, Pauline, additional, Kromer, Charlotte, additional, Loeschner, Katrin, additional, Mutz, Diana, additional, Rakow, Anastasia, additional, Rasmussen, Kirsten, additional, Rauscher, Hubert, additional, Richter, Hannes, additional, Schoon, Janosch, additional, Schmid, Otmar, additional, Som, Claudia, additional, M.Tovar, Günter E., additional, Westerhoff, Paul, additional, Wohlleben, Wendel, additional, Luch, Andreas, additional, and Laux, Peter, additional

Published
2022
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3. Analytical and toxicological aspects of nanomaterials in different product groups: Challenges and opportunities

Author

Tschiche, Harald R., primary, Bierkandt, Frank S., additional, Creutzenberg, Otto, additional, Fessard, Valerie, additional, Franz, Roland, additional, Greiner, Ralf, additional, Gruber-Traub, Carmen, additional, Haas, Karl-Heinz, additional, Haase, Andrea, additional, Hartwig, Andrea, additional, Hesse, Bernhard, additional, Hund-Rinke, Kerstin, additional, Iden, Pauline, additional, Kromer, Charlotte, additional, Loeschner, Katrin, additional, Mutz, Diana, additional, Rakow, Anastasia, additional, Rasmussen, Kirsten, additional, Rauscher, Hubert, additional, Richter, Hannes, additional, Schoon, Janosch, additional, Schmid, Otmar, additional, Som, Claudia, additional, Spindler, Lena M., additional, Tovar, Günter E.M., additional, Westerhoff, Paul, additional, Wohlleben, Wendel, additional, Luch, Andreas, additional, and Laux, Peter, additional

Published
2022
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4. Analytical and toxicological aspects of nanomaterials in different product groups:Challenges and opportunities

Author

Tschiche, Harald R., Bierkandt, Frank S., Creutzenberg, Otto, Fessard, Valerie, Franz, Roland, Greiner, Ralf, Gruber-Traub, Carmen, Haas, Karl-Heinz, Haase, Andrea, Hartwig, Andrea, Hesse, Bernhard, Hund-Rinke, Kerstin, Iden, Pauline, Kromer, Charlotte, Loeschner, Katrin, Mutz, Diana, Rakow, Anastasia, Rasmussen, Kirsten, Rauscher, Hubert, Richter, Hannes, Schoon, Janosch, Schmid, Otmar, Som, Claudia, Spindler, Lena M., Tovar, Günter E. M., Westerhoff, Paul, Wohlleben, Wendel, Luch, Andreas, Laux, Peter, Tschiche, Harald R., Bierkandt, Frank S., Creutzenberg, Otto, Fessard, Valerie, Franz, Roland, Greiner, Ralf, Gruber-Traub, Carmen, Haas, Karl-Heinz, Haase, Andrea, Hartwig, Andrea, Hesse, Bernhard, Hund-Rinke, Kerstin, Iden, Pauline, Kromer, Charlotte, Loeschner, Katrin, Mutz, Diana, Rakow, Anastasia, Rasmussen, Kirsten, Rauscher, Hubert, Richter, Hannes, Schoon, Janosch, Schmid, Otmar, Som, Claudia, Spindler, Lena M., Tovar, Günter E. M., Westerhoff, Paul, Wohlleben, Wendel, Luch, Andreas, and Laux, Peter

Abstract

The widespread integration of engineered nanomaterials into consumer and industrial products creates new challenges and requires innovative approaches in terms of design, testing, reliability, and safety of nanotechnology. The aim of this review article is to give an overview of different product groups in which nanomaterials are present and outline their safety aspects for consumers. Here, release of nanomaterials and related analytical challenges and solutions as well as toxicological considerations, such as dose-metrics, are discussed. Additionally, the utilization of engineered nanomaterials as pharmaceuticals or nutraceuticals to deliver and release cargo molecules is covered. Furthermore, critical pathways for human exposure to nanomaterials, namely inhalation and ingestion, are discussed in the context of risk assessment. Analysis of NMs in food, innovative medicine or food contact materials is discussed. Specific focus is on the presence and release of nanomaterials, including whether nanomaterials can migrate from polymer nanocomposites used in food contact materials. With regard to the toxicology and toxicokinetics of nanomaterials, aspects of dose metrics of inhalation toxicity as well as ingestion toxicology and comparison between in vitro and in vivo conclusions are considered. The definition of dose descriptors to be applied in toxicological testing is emphasized. In relation to potential exposure from different products, opportunities arising from the use of advanced analytical techniques in more unique scenarios such as release of nanomaterials from medical devices such as orthopedic implants are addressed. Alongside higher product performance and complexity, further challenges regarding material characterization and safety, as well as acceptance by the general public are expected.

Published
2022

5. Environmental considerations and current status of grouping and regulation of engineered nanomaterials

Author

Tschiche, Harald R., Bierkandt, Frank S., Creutzenberg, Otto, Fessard, Valerie, Franz, Roland, Giese, Bernd, Greiner, Ralf, Haas, Karl-Heinz, Haase, Andrea, Hartwig, Andrea, Hund-Rinke, Kerstin, Iden, Pauline, Kromer, Charlotte, Loeschner, Katrin, Mutz, Diana, Rakow, Anastasia, Rasmussen, Kirsten, Rauscher, Hubert, Richter, Hannes, Schoon, Janosch, Schmid, Otmar, Som, Claudia, Tovar, Günter E.M., Westerhoff, Paul, Wohlleben, Wendel, Luch, Andreas, Laux, Peter, Tschiche, Harald R., Bierkandt, Frank S., Creutzenberg, Otto, Fessard, Valerie, Franz, Roland, Giese, Bernd, Greiner, Ralf, Haas, Karl-Heinz, Haase, Andrea, Hartwig, Andrea, Hund-Rinke, Kerstin, Iden, Pauline, Kromer, Charlotte, Loeschner, Katrin, Mutz, Diana, Rakow, Anastasia, Rasmussen, Kirsten, Rauscher, Hubert, Richter, Hannes, Schoon, Janosch, Schmid, Otmar, Som, Claudia, Tovar, Günter E.M., Westerhoff, Paul, Wohlleben, Wendel, Luch, Andreas, and Laux, Peter

Abstract

This article reviews the current status of nanotechnology with emphasis on application and related environmental considerations as well as legislation. Application and analysis of nanomaterials in infrastructure (construction, building coatings, and water treatment) is discussed, and in particular nanomaterial release during the lifecycle of these applications. Moreover, possible grouping approaches with regard to ecotoxicological and toxicological properties, and the fate of nanomaterials in the environment are evaluated. In terms of potential exposure, the opportunities that arise from leveraging advances in several key areas, such as water treatment and construction are addressed. Additionally, this review describes challenges with regard to the European Commission’s definition of ‘nanomaterial’. The revised REACH information requirements, intended to enable a comprehensive risk assessment of nanomaterials, are outlined.

Published
2022

6. Use of Cause-and-Effect Analysis to Optimize the Reliability of In Vitro Inhalation Toxicity Measurements Using an Air–Liquid Interface

Author

Petersen, Elijah J., primary, Sharma, Monita, additional, Clippinger, Amy J., additional, Gordon, John, additional, Katz, Aaron, additional, Laux, Peter, additional, Leibrock, Lars B., additional, Luch, Andreas, additional, Matheson, Joanna, additional, Stucki, Andreas O., additional, Tentschert, Jutta, additional, and Bierkandt, Frank S., additional

Published
2021
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8. Use of Cause-and-Effect Analysis to Optimize the Reliability of In VitroInhalation Toxicity Measurements Using an Air–Liquid Interface

Author

Petersen, Elijah J., Sharma, Monita, Clippinger, Amy J., Gordon, John, Katz, Aaron, Laux, Peter, Leibrock, Lars B., Luch, Andreas, Matheson, Joanna, Stucki, Andreas O., Tentschert, Jutta, and Bierkandt, Frank S.

Abstract

In vitroinhalation toxicology methods are increasingly being used for research and regulatory purposes. Although the opportunity for increased human relevance of in vitroinhalation methods compared to in vivotests has been established and discussed, how to systematically account for variability and maximize the reliability of these in vitromethods, especially for assays that use cells cultured at an air–liquid interface (ALI), has received less attention. One tool that has been used to evaluate the robustness of in vitrotest methods is cause-and-effect (C&E) analysis, a conceptual approach to analyze key sources of potential variability in a test method. These sources of variability can then be evaluated using robustness testing and potentially incorporated into in-process control measurements in the assay protocol. There are many differences among in vitroinhalation test methods including the use of different types of biological test systems, exposure platforms/conditions, substances tested, and end points, which represent a major challenge for use in regulatory testing. In this manuscript, we describe how C&E analysis can be applied using a modular approach based on the idea that shared components of different test methods (e.g., the same exposure system is used) have similar sources of variability even though other components may differ. C&E analyses of different in vitroinhalation methods revealed a common set of recommended exposure systems and biological in-process control measurements. The approach described here, when applied in conjunction with Good Laboratory Practices (GLP) criteria, should help improve the inter- and intralaboratory agreement of in vitroinhalation test results, leading to increased confidence in these methods for regulatory and research purposes.

Published
2021
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13. Quantification and visualization of cellular uptake of TiO2 and Ag nanoparticles: comparison of different ICP-MS techniques.

Author

I-Lun Hsiao, Bierkandt, Frank S., Reichardt, Philipp, Luch, Andreas, Yuh-Jeen Huang, Jakubowski, Norbert, Tentschert, Jutta, and Haase, Andrea

Subjects
*SILVER nanoparticles, *INDUCTIVELY coupled plasma mass spectrometry, *NEUROBLASTOMA, *CELL membranes, *LASER ablation
Abstract

Background: Safety assessment of nanoparticles (NPs) requires techniques that are suitable to quantify tissue and cellular uptake of NPs. The most commonly applied techniques for this purpose are based on inductively coupled plasma mass spectrometry (ICP-MS). Here we apply and compare three different ICP-MS methods to investigate the cellular uptake of TiO2 (diameter 7 or 20 nm, respectively) and Ag (diameter 50 or 75 nm, respectively) NPs into differentiated mouse neuroblastoma cells (Neuro-2a cells). Cells were incubated with different amounts of the NPs. Thereafter they were either directly analyzed by laser ablation ICP-MS (LA-ICP-MS) or were lysed and lysates were analyzed by ICP-MS and by single particle ICP-MS (SP-ICP-MS). Results: All techniques confirmed that smaller particles were taken up to a higher extent when values were converted in an NP number-based dose metric. In contrast to ICP-MS and LA-ICP-MS, this measure is already directly provided through SP-ICP-MS. Analysis of NP size distribution in cell lysates by SP-ICP-MS indicates the formation of NP agglomerates inside cells. LA-ICP-MS imaging shows that some of the 75 nm Ag NPs seemed to be adsorbed onto the cell membranes and were not penetrating into the cells, while most of the 50 nm Ag NPs were internalized. LA-ICPMS confirms high cell-to-cell variability for NP uptake. Conclusions: Based on our data we propose to combine different ICP-MS techniques in order to reliably determine the average NP mass and number concentrations, NP sizes and size distribution patterns as well as cell-to-cell variations in NP uptake and intracellular localization. [ABSTRACT FROM AUTHOR]

Published
2016
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14. Parametric Optimization of an Air–Liquid Interface System for Flow-Through Inhalation Exposure to Nanoparticles: Assessing Dosimetry and Intracellular Uptake of CeO 2 Nanoparticles.

Author

Leibrock, Lars B., Jungnickel, Harald, Tentschert, Jutta, Katz, Aaron, Toman, Blaza, Petersen, Elijah J., Bierkandt, Frank S., Singh, Ajay Vikram, Laux, Peter, and Luch, Andreas

Subjects
RADIATION dosimetry, NANOPARTICLES, IN vivo studies, HUMIDITY, CELL survival
Abstract

Air–liquid interface (ALI) systems have been widely used in recent years to investigate the inhalation toxicity of many gaseous compounds, chemicals, and nanomaterials and represent an emerging and promising in vitro method to supplement in vivo studies. ALI exposure reflects the physiological conditions of the deep lung more closely to subacute in vivo inhalation scenarios compared to submerged exposure. The comparability of the toxicological results obtained from in vivo and in vitro inhalation data is still challenging. The robustness of ALI exposure scenarios is not yet well understood, but critical for the potential standardization of these methods. We report a cause-and-effect (C&E) analysis of a flow through ALI exposure system. The influence of five different instrumental and physiological parameters affecting cell viability and exposure parameters of a human lung cell line in vitro (exposure duration, relative humidity, temperature, CO2 concentration and flow rate) was investigated. After exposing lung epithelia cells to a CeO2 nanoparticle (NP) aerosol, intracellular CeO2 concentrations reached values similar to those found in a recent subacute rat inhalation study in vivo. This is the first study showing that the NP concentration reached in vitro using a flow through ALI system were the same as those in an in vivo study. [ABSTRACT FROM AUTHOR]

Published
2020
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