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10 results on '"Biesma, Hedde D."'

2. Microsatellite instability and sex differences in resectable gastric cancer – A pooled analysis of three European cohorts

Author

Quaas, Alexander, Biesma, Hedde D., Wagner, Anna D., Verheij, Marcel, van Berge Henegouwen, Mark I., Schoemig-Markiefka, Birgid, Pamuk, Aylin, Zander, Thomas, Siemanowski, Janna, Sikorska, Karolina, Egthuijsen, Jacqueline M.P., Meershoek-Klein Kranenbarg, Elma M., van de Velde, Cornelis J.H., Buettner, Reinhard, Alakus, Hakan, Cats, Annemieke, Ylstra, Bauke, van Laarhoven, Hanneke W.M., and van Grieken, Nicole C.T.

Published
2022
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3. Response to neoadjuvant chemotherapy and survival in molecular subtypes of resectable gastric cancer: a post hoc analysis of the D1/D2 and CRITICS trials

Author

Biesma, Hedde D., Soeratram, Tanya T. D., Sikorska, Karolina, Caspers, Irene A., van Essen, Hendrik F., Egthuijsen, Jacqueline M. P., Mookhoek, Aart, van Laarhoven, Hanneke W. M., van Berge Henegouwen, Mark I., Nordsmark, Marianne, van der Peet, Donald L., Warmerdam, Fabienne A. R. M., Geenen, Maud M., Loosveld, Olaf J. L., Portielje, Johanneke E. A., Los, Maartje, Heideman, Daniëlle A. M., Meershoek-Klein Kranenbarg, Elma, Hartgrink, Henk H., van Sandick, Johanna, Verheij, Marcel, van de Velde, Cornelis J. H., Cats, Annemieke, Ylstra, Bauke, and van Grieken, Nicole C. T.

Published
2022
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4. Abstract 1727: CD8+ T cells in the invasive margin combined with FOXP3+ T cells in the tumor center significantly associate with survival in resectable gastric cancer, a post-hoc analysis of the Dutch D1/D2 trial

Author

Soeratram, Tanya T., primary, Biesma, Hedde D., additional, Egthuijsen, Jacqueline M., additional, Kranenbarg, Elma Meershoek-Klein, additional, Hartgrink, Henk H., additional, van de Velde, Cornelis J., additional, van Dijk, Erik, additional, Kim, Yongsoo, additional, Ylstra, Bauke, additional, van Laarhoven, Hanneke W., additional, and van Grieken, Nicole C., additional

Published
2022
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5. Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab

Author

van Dijk, Erik, primary, Biesma, Hedde D., additional, Cordes, Martijn, additional, Smeets, Dominiek, additional, Neerincx, Maarten, additional, Das, Sudipto, additional, Eijk, Paul P., additional, Murphy, Verena, additional, Barat, Anna, additional, Bacon, Orna, additional, Prehn, Jochen H.M., additional, Betge, Johannes, additional, Gaiser, Timo, additional, Fender, Bozena, additional, Meijer, Gerrit A., additional, McNamara, Deborah A., additional, Klinger, Rut, additional, Koopman, Miriam, additional, Ebert, Matthias P.A., additional, Kay, Elaine W., additional, Hennessey, Bryan T., additional, Verheul, Henk M.W., additional, Gallagher, William M., additional, O'Connor, Darran P., additional, Punt, Cornelis J.A., additional, Loupakis, Fotios, additional, Lambrechts, Diether, additional, Byrne, Annette T., additional, van Grieken, Nicole C.T., additional, and Ylstra, Bauke, additional

Published
2018
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6. Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab

Author

Van Dijk, Erik, Biesma, Hedde D., Cordes, Martijn, Smeets, Dominiek, Neerincx, Maarten, Das, Sudipto, Eijk, Paul P., Murphy, Verena, Barat, Anna, Bacon, Orna, Prehn, Jochen H.M., Betge, Johannes, Gaiser, Timo, Fender, Bozena, Meijer, Gerrit A., McNamara, Deborah A., Klinger, Rut, Koopman, Miriam, Ebert, Matthias P.A., Kay, Elaine W., Hennessey, Bryan T., Verheul, Henk M.W., Gallagher, William M., O’Connor, Darran P., Punt, Cornelis J.A., Loupakis, Fotios, Lambrechts, Diether, Byrne, Annette T., Van Grieken, Nicole C.T., Ylstra, Bauke, Van Dijk, Erik, Biesma, Hedde D., Cordes, Martijn, Smeets, Dominiek, Neerincx, Maarten, Das, Sudipto, Eijk, Paul P., Murphy, Verena, Barat, Anna, Bacon, Orna, Prehn, Jochen H.M., Betge, Johannes, Gaiser, Timo, Fender, Bozena, Meijer, Gerrit A., McNamara, Deborah A., Klinger, Rut, Koopman, Miriam, Ebert, Matthias P.A., Kay, Elaine W., Hennessey, Bryan T., Verheul, Henk M.W., Gallagher, William M., O’Connor, Darran P., Punt, Cornelis J.A., Loupakis, Fotios, Lambrechts, Diether, Byrne, Annette T., Van Grieken, Nicole C.T., and Ylstra, Bauke

Published
2018

7. Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab

Author

MS Mondziekten/Kaakchirurgie, MS Medische Oncologie, Van Dijk, Erik, Biesma, Hedde D., Cordes, Martijn, Smeets, Dominiek, Neerincx, Maarten, Das, Sudipto, Eijk, Paul P., Murphy, Verena, Barat, Anna, Bacon, Orna, Prehn, Jochen H.M., Betge, Johannes, Gaiser, Timo, Fender, Bozena, Meijer, Gerrit A., McNamara, Deborah A., Klinger, Rut, Koopman, Miriam, Ebert, Matthias P.A., Kay, Elaine W., Hennessey, Bryan T., Verheul, Henk M.W., Gallagher, William M., O’Connor, Darran P., Punt, Cornelis J.A., Loupakis, Fotios, Lambrechts, Diether, Byrne, Annette T., Van Grieken, Nicole C.T., Ylstra, Bauke, MS Mondziekten/Kaakchirurgie, MS Medische Oncologie, Van Dijk, Erik, Biesma, Hedde D., Cordes, Martijn, Smeets, Dominiek, Neerincx, Maarten, Das, Sudipto, Eijk, Paul P., Murphy, Verena, Barat, Anna, Bacon, Orna, Prehn, Jochen H.M., Betge, Johannes, Gaiser, Timo, Fender, Bozena, Meijer, Gerrit A., McNamara, Deborah A., Klinger, Rut, Koopman, Miriam, Ebert, Matthias P.A., Kay, Elaine W., Hennessey, Bryan T., Verheul, Henk M.W., Gallagher, William M., O’Connor, Darran P., Punt, Cornelis J.A., Loupakis, Fotios, Lambrechts, Diether, Byrne, Annette T., Van Grieken, Nicole C.T., and Ylstra, Bauke

Published
2018

8. Copy number profiling by array comparative genomic hybridization identifies frequently occurring BRCA2-like male breast cancer

Author

Biesma, Hedde D, Schouten, Philip C, Lacle, Miangela M, Sanders, Joyce, Brugman, Wim, Kerkhoven, Ron, Mandjes, Ingrid, van der Groep, Petra, van Diest, Paul J, and Linn, Sabine C

Subjects
endocrine system diseases, skin and connective tissue diseases, neoplasms
Abstract

Genomic aberrations can be used to subtype breast cancer. In this study, we investigated DNA copy number (CN) profiles of 69 cases of male breast cancer (MBC) by array comparative genomic hybridization (aCGH) to detect recurrent gains and losses in comparison with female breast cancers (FBC). Further, we classified these profiles as BRCA1-like, BRCA2-like or non-BRCA-like profiles using previous classifiers derived from FBC, and correlated these profiles with pathological characteristics. We observed large CN gains on chromosome arms 1q, 5p, 8q, 10p, 16p, 17q, and chromosomes 20 and X. Large losses were seen on chromosomes/chromosome arms 1p, 6p, 8p, 9, 11q, 13, 14q, 16q, 17p, and 22. The pattern of gains and losses in estrogen receptor positive (ER+) MBC was largely similar to ER+ FBC, except for gains on chromosome X in MBC, which were uncommon in FBC. Out of 69 MBC patients, 15 patients (22%) had a BRCA2-like profile, of which 2 (3%) were also BRCA1-like. One patient (1%) was only BRCA1-like; the remaining 53 (77%) patients were classified as non-BRCA-like. BRCA2-like cases were more often p53 accumulated than non-BRCA-like cases (P = 0.014). In conclusion, the pattern of gains and losses in ER+ MBC was largely similar to that of its ER+ FBC counterpart, except for gains on chromosome X in MBC, which are uncommon in FBC. A significant proportion of MBC has a BRCA2-like aCGH profile, pointing to a potentially hereditary nature, and indicating that they could benefit from a drug regimen targeting BRCA defects as in FBC. © 2015 Wiley Periodicals, Inc.

Published
2015

9. Copy number profiling by array comparative genomic hybridization identifies frequently occurring BRCA2-like male breast cancer

Author

Pathologie Pathologen staf, Pathologie, Cancer, Biesma, Hedde D, Schouten, Philip C, Lacle, Miangela M, Sanders, Joyce, Brugman, Wim, Kerkhoven, Ron, Mandjes, Ingrid, van der Groep, Petra, van Diest, Paul J, Linn, Sabine C, Pathologie Pathologen staf, Pathologie, Cancer, Biesma, Hedde D, Schouten, Philip C, Lacle, Miangela M, Sanders, Joyce, Brugman, Wim, Kerkhoven, Ron, Mandjes, Ingrid, van der Groep, Petra, van Diest, Paul J, and Linn, Sabine C

Published
2015

10. Copy number profiling by array comparative genomic hybridization identifies frequently occurring BRCA2-like male breast cancer.

Author

Biesma HD, Schouten PC, Lacle MM, Sanders J, Brugman W, Kerkhoven R, Mandjes I, van der Groep P, van Diest PJ, and Linn SC

Subjects
Adult, Aged, Aged, 80 and over, BRCA1 Protein genetics, Breast Neoplasms, Male pathology, Comparative Genomic Hybridization methods, Female, Humans, Male, Middle Aged, Neoplasm Grading, Tumor Suppressor Protein p53 metabolism, BRCA2 Protein genetics, Breast Neoplasms, Male classification, Breast Neoplasms, Male genetics, Chromosome Aberrations, DNA Copy Number Variations
Abstract

Genomic aberrations can be used to subtype breast cancer. In this study, we investigated DNA copy number (CN) profiles of 69 cases of male breast cancer (MBC) by array comparative genomic hybridization (aCGH) to detect recurrent gains and losses in comparison with female breast cancers (FBC). Further, we classified these profiles as BRCA1-like, BRCA2-like or non-BRCA-like profiles using previous classifiers derived from FBC, and correlated these profiles with pathological characteristics. We observed large CN gains on chromosome arms 1q, 5p, 8q, 10p, 16p, 17q, and chromosomes 20 and X. Large losses were seen on chromosomes/chromosome arms 1p, 6p, 8p, 9, 11q, 13, 14q, 16q, 17p, and 22. The pattern of gains and losses in estrogen receptor positive (ER+) MBC was largely similar to ER+ FBC, except for gains on chromosome X in MBC, which were uncommon in FBC. Out of 69 MBC patients, 15 patients (22%) had a BRCA2-like profile, of which 2 (3%) were also BRCA1-like. One patient (1%) was only BRCA1-like; the remaining 53 (77%) patients were classified as non-BRCA-like. BRCA2-like cases were more often p53 accumulated than non-BRCA-like cases (P = 0.014). In conclusion, the pattern of gains and losses in ER+ MBC was largely similar to that of its ER+ FBC counterpart, except for gains on chromosome X in MBC, which are uncommon in FBC. A significant proportion of MBC has a BRCA2-like aCGH profile, pointing to a potentially hereditary nature, and indicating that they could benefit from a drug regimen targeting BRCA defects as in FBC., (© 2015 Wiley Periodicals, Inc.)

Published
2015
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