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10 results on '"Biffi, Stefano"'

1. GRAd-COV2 vaccine provides potent and durable humoral and cellular immunity to SARS-CoV-2 in randomized placebo-controlled phase 2 trial

Author

Ziviani, Luigi, Malescio, Feliciana, Turrini, Irene, Lawlor, Rita, Romano, Annamaria, Nunziata, Mariagrazia, Armato, Salvatore, Mazzeo, Nicole, Carleo, Maria Aurora, Dell’Isola, Chiara, Pisapia, Raffaella, Pontarelli, Agostina, Olivani, Andrea, Grasselli, Sara, Laccabue, Diletta, Leoni, Maria Cristina, Paolillo, Franco, Mancini, Annalisa, Ruaro, Barbara, Confalonieri, Marco, Salton, Francesco, Mancarella, Giulia, Marocco, Raffaella, De Masi, Margherita, Belvisi, Valeria, Lamonica, Silvia, Cingolani, Antonella, Seguiti, Cristina, Brambilla, Paola, Ferraresi, Alice, Lupi, Matteo, Ludovisi, Serena, Renisi, Giulia, Massafra, Roberta, Pellicciotta, Martina, Armiento, Luciana, Vimercati, Stefania, Piacenza, Mariagrazia, Bonfanti, Paolo, Columpsi, Paola, Cazzaniga, Marina Elena, Rovelli, Cristina, Ceresini, Mariaelena, Previtali, Letizia, Trentini, Laura, Alcantarini, Chiara, Rugge, Walter, Biffi, Stefano, Poletti, Federica, Rostagno, Roberto, Moglia, Roberta, De Negri, Ferdinando, Fini, Elisabetta, Cangialosi, Alice, Bruno, Serena Rita, Rizzo, Marianna, Niglio, Mariangela, Stritto, Anna Dello, Matano, Alfredo, Petruzziello, Arnolfo, Valsecchi, Pietro, Pieri, Teresa, Altamura, Mauro, Calamo, Angela, Giannelli, Anna, Menolascina, Stefania, Di Bari, Silvia, Mauro, Vera, Aronica, Raissa, Segala, Daniela, Cultrera, Rosario, Sighinolfi, Laura, Abbott, Michelle, Gizzi, Andrea, Marascia, Federica Guida, Valenti, Giacomo, Feasi, Marcello, Bobbio, Nicoletta, Del Puente, Filippo, Nicosia, Alfredo, Frascà, Martina, Mazzoleni, Miriam, Garofalo, Nadia, Ammendola, Virginia, Grazioli, Fabiana, Napolitano, Federico, Vitelli, Alessandra, Marcellini, Valentina, Capone, Stefania, Fusco, Francesco M., Milleri, Stefano, Borrè, Silvio, Carbonara, Sergio, Lo Caputo, Sergio, Leone, Sebastiano, Gori, Giovanni, Maggi, Paolo, Cascio, Antonio, Lichtner, Miriam, Cauda, Roberto, Dal Zoppo, Sarah, Cossu, Maria V., Gori, Andrea, Roda, Silvia, Confalonieri, Paola, Bonora, Stefano, Missale, Gabriele, Codeluppi, Mauro, Mezzaroma, Ivano, Capici, Serena, Pontali, Emanuele, Libanore, Marco, Diani, Augusta, Lanini, Simone, Battella, Simone, Contino, Alessandra M., Piano Mortari, Eva, Genova, Francesco, Parente, Gessica, Dragonetti, Rosella, Colloca, Stefano, Visani, Luigi, Iannacone, Claudio, Carsetti, Rita, Folgori, Antonella, and Camerini, Roberto

Published
2023
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7. Combination Antifungal Therapy for Invasive Mold Infections Among Pediatric Patients with Hematological Malignancies: Data from A Real-Life Case-Series

Author

Peri, Anna Maria, primary, Verna, Marta, additional, Biffi, Stefano, additional, Alagna, Laura, additional, Longhi, Benedetta, additional, Migliorino, Guglielmo Marco, additional, Foresti, Sergio, additional, Bandera, Alessandra, additional, Rovelli, Attilio, additional, Rizzari, Carmelo, additional, Gori, Andrea, additional, and Colombini, Antonella, additional

Published
2019
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10. GRAd-COV2 vaccine provides potent and durable humoral and cellular immunity to SARS-CoV-2 in randomized placebo-controlled phase 2 trial (COVITAR)

Author

Capone, Stefania, Fusco, Francesco M., Milleri, Stefano, Borrè, Silvio, Carbonara, Sergio, Lo Caputo, Sergio, Leone, Sebastiano, Gori, Giovanni, Maggi, Paolo, Cascio, Antonio, Lichtner, Miriam, Cauda, Roberto, Zoppo, Sarah Dal, Cossu, Maria V., Gori, Andrea, Roda, Silvia, Confalonieri, Paola, Bonora, Stefano, Missale, Gabriele, Codeluppi, Mauro, Mezzaroma, Ivano, Capici, Serena, Pontali, Emanuele, Libanore, Marco, Diani, Augusta, Lanini, Simone, Battella, Simone, Contino, Alessandra M., Mortari, Eva Piano, Genova, Francesco, Parente, Gessica, Dragonetti, Rosella, Colloca, Stefano, Visani, Luigi, Iannacone, Claudio, Carsetti, Rita, Folgori, Antonella, Camerini, Roberto, Ziviani, Luigi, Malescio, Feliciana, Turrini, Irene, Lawlor, Rita, Romano, Annamaria, Nunziata, Mariagrazia, Armato, Salvatore, Mazzeo, Nicole, Carleo, Maria Aurora, Dell’Isola, Chiara, Pisapia, Raffaella, Pontarelli, Agostina, Olivani, Andrea, Grasselli, Sara, Laccabue, Diletta, Leoni, Maria Cristina, Paolillo, Franco, Mancini, Annalisa, Ruaro, Barbara, Confalonieri, Marco, Salton, Francesco, Mancarella, Giulia, Marocco, Raffaella, De Masi, Margherita, Belvisi, Valeria, Lamonica, Silvia, Cingolani, Antonella, Seguiti, Cristina, Brambilla, Paola, Ferraresi, Alice, Lupi, Matteo, Ludovisi, Serena, Renisi, Giulia, Massafra, Roberta, Pellicciotta, Martina, Armiento, Luciana, Vimercati, Stefania, Piacenza, Mariagrazia, Bonfanti, Paolo, Columpsi, Paola, Cazzaniga, Marina Elena, Rovelli, Cristina, Ceresini, Mariaelena, Previtali, Letizia, Trentini, Laura, Alcantarini, Chiara, Rugge, Walter, Biffi, Stefano, Poletti, Federica, Rostagno, Roberto, Moglia, Roberta, De Negri, Ferdinando, Fini, Elisabetta, Cangialosi, Alice, Bruno, Serena Rita, Rizzo, Marianna, Niglio, Mariangela, Stritto, Anna Dello, Matano, Alfredo, Petruzziello, Arnolfo, Valsecchi, Pietro, Pieri, Teresa, Altamura, Mauro, Calamo, Angela, Giannelli, Anna, Menolascina, Stefania, Di Bari, Silvia, Mauro, Vera, Aronica, Raissa, Segala, Daniela, Cultrera, Rosario, Sighinolfi, Laura, Abbott, Michelle, Gizzi, Andrea, Marascia, Federica Guida, Valenti, Giacomo, Feasi, Marcello, Bobbio, Nicoletta, Del Puente, Filippo, Nicosia, Alfredo, Frascà, Martina, Mazzoleni, Miriam, Garofalo, Nadia, Ammendola, Virginia, Grazioli, Fabiana, Napolitano, Federico, Vitelli, Alessandra, and Marcellini, Valentina

Abstract

The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and heterologous immunization approaches implemented worldwide for booster doses call for diversified vaccine portfolios. GRAd-COV2 is a gorilla adenovirus-based COVID-19 vaccine candidate encoding prefusion-stabilized spike. The safety and immunogenicity of GRAd-COV2 is evaluated in a dose- and regimen-finding phase 2 trial (ClinicalTrials.gov: NCT04791423) whereby 917 eligible participants are randomized to receive a single intramuscular GRAd-COV2 administration followed by placebo, or two vaccine injections, or two doses of placebo, spaced over 3 weeks. Here, we report that GRAd-COV2 is well tolerated and induces robust immune responses after a single immunization; a second administration increases binding and neutralizing antibody titers. Potent, variant of concern (VOC) cross-reactive spike-specific T cell response peaks after the first dose and is characterized by high frequencies of CD8s. T cells maintain immediate effector functions and high proliferative potential over time. Thus, GRAd vector is a valuable platform for genetic vaccine development, especially when robust CD8 response is needed.

Published
2023
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