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1. Toxicités hématologiques après CAR-T cells, recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC)

Author

Alsuliman, Tamim, primary, Aubrun, Clotilde, additional, Bay, Jacques Olivier, additional, Beguin, Yves, additional, Bigenwald, Camille, additional, Brissot, Eolia, additional, Chalandon, Yves, additional, Chevallier, Patrice, additional, Pagliuca, Simona, additional, Magro, Léonardo, additional, and Srour, Micha, additional

Published
2024
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2. Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders

Author

Wilk, C. Matthias, primary, Cathomas, Flurin, additional, Török, Orsolya, additional, Le Berichel, Jessica, additional, Park, Matthew D., additional, Bigenwald, Camille, additional, Heaton, George R., additional, Hamon, Pauline, additional, Troncoso, Leanna, additional, Scull, Brooks P., additional, Dangoor, Diana, additional, Silvin, Aymeric, additional, Fleischmann, Ryan, additional, Belabed, Meriem, additional, Lin, Howard, additional, Merad Taouli, Elias, additional, Boettcher, Steffen, additional, Li, Long, additional, Aubry, Antonio, additional, Manz, Markus G., additional, Kofler, Julia K., additional, Yue, Zhenyu, additional, Lira, Sergio A., additional, Ginhoux, Florent, additional, Crary, John F., additional, McClain, Kenneth L., additional, Picarsic, Jennifer L., additional, Russo, Scott J., additional, Allen, Carl E., additional, and Merad, Miriam, additional

Published
2023
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3. Supplementary Figure S3 from BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

Author

Zhao, Liwei, primary, Liu, Peng, primary, Mao, Misha, primary, Zhang, Shuai, primary, Bigenwald, Camille, primary, Dutertre, Charles-Antoine, primary, Lehmann, Christian H.K., primary, Pan, Hui, primary, Paulhan, Nicolas, primary, Amon, Lukas, primary, Buqué, Aitziber, primary, Yamazaki, Takahiro, primary, Galluzzi, Lorenzo, primary, Kloeckner, Benoit, primary, Silvin, Aymeric, primary, Pan, Yuhong, primary, Chen, Hui, primary, Tian, Ai-Ling, primary, Ly, Pierre, primary, Dudziak, Diana, primary, Zitvogel, Laurence, primary, Kepp, Oliver, primary, and Kroemer, Guido, primary

Published
2023
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4. Supplementary Table S4 from BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

Author

Zhao, Liwei, primary, Liu, Peng, primary, Mao, Misha, primary, Zhang, Shuai, primary, Bigenwald, Camille, primary, Dutertre, Charles-Antoine, primary, Lehmann, Christian H.K., primary, Pan, Hui, primary, Paulhan, Nicolas, primary, Amon, Lukas, primary, Buqué, Aitziber, primary, Yamazaki, Takahiro, primary, Galluzzi, Lorenzo, primary, Kloeckner, Benoit, primary, Silvin, Aymeric, primary, Pan, Yuhong, primary, Chen, Hui, primary, Tian, Ai-Ling, primary, Ly, Pierre, primary, Dudziak, Diana, primary, Zitvogel, Laurence, primary, Kepp, Oliver, primary, and Kroemer, Guido, primary

Published
2023
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5. Data from BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

Author

Zhao, Liwei, primary, Liu, Peng, primary, Mao, Misha, primary, Zhang, Shuai, primary, Bigenwald, Camille, primary, Dutertre, Charles-Antoine, primary, Lehmann, Christian H.K., primary, Pan, Hui, primary, Paulhan, Nicolas, primary, Amon, Lukas, primary, Buqué, Aitziber, primary, Yamazaki, Takahiro, primary, Galluzzi, Lorenzo, primary, Kloeckner, Benoit, primary, Silvin, Aymeric, primary, Pan, Yuhong, primary, Chen, Hui, primary, Tian, Ai-Ling, primary, Ly, Pierre, primary, Dudziak, Diana, primary, Zitvogel, Laurence, primary, Kepp, Oliver, primary, and Kroemer, Guido, primary

Published
2023
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6. Supplementary Table Legends from BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

Author

Zhao, Liwei, primary, Liu, Peng, primary, Mao, Misha, primary, Zhang, Shuai, primary, Bigenwald, Camille, primary, Dutertre, Charles-Antoine, primary, Lehmann, Christian H.K., primary, Pan, Hui, primary, Paulhan, Nicolas, primary, Amon, Lukas, primary, Buqué, Aitziber, primary, Yamazaki, Takahiro, primary, Galluzzi, Lorenzo, primary, Kloeckner, Benoit, primary, Silvin, Aymeric, primary, Pan, Yuhong, primary, Chen, Hui, primary, Tian, Ai-Ling, primary, Ly, Pierre, primary, Dudziak, Diana, primary, Zitvogel, Laurence, primary, Kepp, Oliver, primary, and Kroemer, Guido, primary

Published
2023
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7. BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

Author

Bigenwald, Camille, Le Berichel, Jessica, Wilk, C. Matthias, Chakraborty, Rikhia, Chen, Steven T., Tabachnikova, Alexandra, Mancusi, Rebecca, Abhyankar, Harshal, Casanova-Acebes, Maria, Laface, Ilaria, Akturk, Guray, Jobson, Jenielle, Karoulia, Zoi, Martin, Jerome C., Grout, John, Rafiei, Anahita, Lin, Howard, Manz, Markus G., Baccarini, Alessia, Poulikakos, Poulikos I., Brown, Brian D., Gnjatic, Sacha, Lujambio, Amaia, McClain, Kenneth L., Picarsic, Jennifer, Allen, Carl E., and Merad, Miriam

Published
2021
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8. Histiocytic disorders

Author

McClain, Kenneth L., Bigenwald, Camille, Collin, Matthew, Haroche, Julien, Marsh, Rebecca A., Merad, Miriam, Picarsic, Jennifer, Ribeiro, Karina B., and Allen, Carl E.

Published
2021
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10. When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes

Author

Willekens, Christophe, primary, Chahine, Claude, additional, Dragani, Matteo, additional, Khalife‐Hachem, Sabine, additional, Bigenwald, Camille, additional, Rossignol, Julien, additional, Castilla‐Llorente, Cristina, additional, Danu, Alina, additional, Michot, Jean‐Marie, additional, Saada, Veronique, additional, Cotteret, Sophie, additional, Marzac, Christophe, additional, Renneville, Aline, additional, Plo, Isabelle, additional, Broutin, Sophie, additional, Bosselut, Nelly, additional, Cassinat, Bruno, additional, Lazarovici, Julien, additional, Droin, Nathalie, additional, and De Botton, Stephane, additional

Published
2023
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12. Data from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals

Author

Fahrner, Jean-Eudes, primary, Lahmar, Imran, primary, Goubet, Anne-Gaëlle, primary, Haddad, Yacine, primary, Carrier, Agathe, primary, Mazzenga, Marine, primary, Drubay, Damien, primary, Alves Costa Silva, Carolina, primary, de Sousa, Eric, primary, Thelemaque, Cassandra, primary, Melenotte, Cléa, primary, Dubuisson, Agathe, primary, Geraud, Arthur, primary, Ferrere, Gladys, primary, Birebent, Roxanne, primary, Bigenwald, Camille, primary, Picard, Marion, primary, Cerbone, Luigi, primary, Lérias, Joana R., primary, Laparra, Ariane, primary, Bernard-Tessier, Alice, primary, Kloeckner, Benoît, primary, Gazzano, Marianne, primary, Danlos, François-Xavier, primary, Terrisse, Safae, primary, Pizzato, Eugenie, primary, Flament, Caroline, primary, Ly, Pierre, primary, Tartour, Eric, primary, Benhamouda, Nadine, primary, Meziani, Lydia, primary, Ahmed-Belkacem, Abdelhakim, primary, Miyara, Makoto, primary, Gorochov, Guy, primary, Barlesi, Fabrice, primary, Trubert, Alexandre, primary, Ungar, Benjamin, primary, Estrada, Yeriel, primary, Pradon, Caroline, primary, Gallois, Emmanuelle, primary, Pommeret, Fanny, primary, Colomba, Emeline, primary, Lavaud, Pernelle, primary, Deloger, Marc, primary, Droin, Nathalie, primary, Deutsch, Eric, primary, Gachot, Bertrand, primary, Spano, Jean-Philippe, primary, Merad, Mansouria, primary, Scotté, Florian, primary, Marabelle, Aurélien, primary, Griscelli, Frank, primary, Blay, Jean-Yves, primary, Soria, Jean-Charles, primary, Merad, Miriam, primary, André, Fabrice, primary, Villemonteix, Juliette, primary, Chevalier, Mathieu F., primary, Caillat-Zucman, Sophie, primary, Fenollar, Florence, primary, Guttman-Yassky, Emma, primary, Launay, Odile, primary, Kroemer, Guido, primary, La Scola, Bernard, primary, Maeurer, Markus, primary, Derosa, Lisa, primary, and Zitvogel, Laurence, primary

Published
2023
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13. Supplementary Data from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals

Author

Fahrner, Jean-Eudes, primary, Lahmar, Imran, primary, Goubet, Anne-Gaëlle, primary, Haddad, Yacine, primary, Carrier, Agathe, primary, Mazzenga, Marine, primary, Drubay, Damien, primary, Alves Costa Silva, Carolina, primary, de Sousa, Eric, primary, Thelemaque, Cassandra, primary, Melenotte, Cléa, primary, Dubuisson, Agathe, primary, Geraud, Arthur, primary, Ferrere, Gladys, primary, Birebent, Roxanne, primary, Bigenwald, Camille, primary, Picard, Marion, primary, Cerbone, Luigi, primary, Lérias, Joana R., primary, Laparra, Ariane, primary, Bernard-Tessier, Alice, primary, Kloeckner, Benoît, primary, Gazzano, Marianne, primary, Danlos, François-Xavier, primary, Terrisse, Safae, primary, Pizzato, Eugenie, primary, Flament, Caroline, primary, Ly, Pierre, primary, Tartour, Eric, primary, Benhamouda, Nadine, primary, Meziani, Lydia, primary, Ahmed-Belkacem, Abdelhakim, primary, Miyara, Makoto, primary, Gorochov, Guy, primary, Barlesi, Fabrice, primary, Trubert, Alexandre, primary, Ungar, Benjamin, primary, Estrada, Yeriel, primary, Pradon, Caroline, primary, Gallois, Emmanuelle, primary, Pommeret, Fanny, primary, Colomba, Emeline, primary, Lavaud, Pernelle, primary, Deloger, Marc, primary, Droin, Nathalie, primary, Deutsch, Eric, primary, Gachot, Bertrand, primary, Spano, Jean-Philippe, primary, Merad, Mansouria, primary, Scotté, Florian, primary, Marabelle, Aurélien, primary, Griscelli, Frank, primary, Blay, Jean-Yves, primary, Soria, Jean-Charles, primary, Merad, Miriam, primary, André, Fabrice, primary, Villemonteix, Juliette, primary, Chevalier, Mathieu F., primary, Caillat-Zucman, Sophie, primary, Fenollar, Florence, primary, Guttman-Yassky, Emma, primary, Launay, Odile, primary, Kroemer, Guido, primary, La Scola, Bernard, primary, Maeurer, Markus, primary, Derosa, Lisa, primary, and Zitvogel, Laurence, primary

Published
2023
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14. Supplementary Figure from The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals

Author

Fahrner, Jean-Eudes, primary, Lahmar, Imran, primary, Goubet, Anne-Gaëlle, primary, Haddad, Yacine, primary, Carrier, Agathe, primary, Mazzenga, Marine, primary, Drubay, Damien, primary, Alves Costa Silva, Carolina, primary, de Sousa, Eric, primary, Thelemaque, Cassandra, primary, Melenotte, Cléa, primary, Dubuisson, Agathe, primary, Geraud, Arthur, primary, Ferrere, Gladys, primary, Birebent, Roxanne, primary, Bigenwald, Camille, primary, Picard, Marion, primary, Cerbone, Luigi, primary, Lérias, Joana R., primary, Laparra, Ariane, primary, Bernard-Tessier, Alice, primary, Kloeckner, Benoît, primary, Gazzano, Marianne, primary, Danlos, François-Xavier, primary, Terrisse, Safae, primary, Pizzato, Eugenie, primary, Flament, Caroline, primary, Ly, Pierre, primary, Tartour, Eric, primary, Benhamouda, Nadine, primary, Meziani, Lydia, primary, Ahmed-Belkacem, Abdelhakim, primary, Miyara, Makoto, primary, Gorochov, Guy, primary, Barlesi, Fabrice, primary, Trubert, Alexandre, primary, Ungar, Benjamin, primary, Estrada, Yeriel, primary, Pradon, Caroline, primary, Gallois, Emmanuelle, primary, Pommeret, Fanny, primary, Colomba, Emeline, primary, Lavaud, Pernelle, primary, Deloger, Marc, primary, Droin, Nathalie, primary, Deutsch, Eric, primary, Gachot, Bertrand, primary, Spano, Jean-Philippe, primary, Merad, Mansouria, primary, Scotté, Florian, primary, Marabelle, Aurélien, primary, Griscelli, Frank, primary, Blay, Jean-Yves, primary, Soria, Jean-Charles, primary, Merad, Miriam, primary, André, Fabrice, primary, Villemonteix, Juliette, primary, Chevalier, Mathieu F., primary, Caillat-Zucman, Sophie, primary, Fenollar, Florence, primary, Guttman-Yassky, Emma, primary, Launay, Odile, primary, Kroemer, Guido, primary, La Scola, Bernard, primary, Maeurer, Markus, primary, Derosa, Lisa, primary, and Zitvogel, Laurence, primary

Published
2023
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15. Myelodysplastic syndrome following chimeric antigen receptor T-cell therapy treated with allogenic stem cell transplantation

Author

Saleh, Khalil, primary, Arbab, Ahmadreza, additional, Ghez, David, additional, Bigenwald, Camille, additional, Cotteret, Sophie, additional, Marzac, Christophe, additional, Pasquier, Florence, additional, Pilorge, Sylvain, additional, Saada, Véronique, additional, Vergé, Véronique, additional, Ribrag, Vincent, additional, and Castilla-Llorente, Cristina, additional

Published
2023
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16. Sequence analyses of relapsed or refractory diffuse large B‐cell lymphomas unravel three genetic subgroups of patients and theGNA13mutant as poor prognostic biomarker, results of LNH‐EP1 study

Author

Michot, Jean‐Marie, primary, Quivoron, Cyril, additional, Sarkozy, Clémentine, additional, Danu, Alina, additional, Lazarovici, Julien, additional, Saleh, Khalil, additional, El‐Dakdouki, Yolla, additional, Goldschmidt, Vincent, additional, Bigenwald, Camille, additional, Dragani, Matteo, additional, Bahleda, Rastislav, additional, Baldini, Capucine, additional, Arfi‐Rouche, Julia, additional, Martin‐Romano, Patricia, additional, Tselikas, Lambros, additional, Gazzah, Anas, additional, Hollebecque, Antoine, additional, Lacroix, Ludovic, additional, Ghez, David, additional, Vergé, Veronique, additional, Marzac, Christophe, additional, Cotteret, Sophie, additional, Rahali, Wassila, additional, Soria, Jean‐Charles, additional, Massard, Christophe, additional, Bernard, Olivier A., additional, Dartigues, Peggy, additional, Camara‐Clayette, Valérie, additional, and Ribrag, Vincent, additional

Published
2023
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17. RBD- specific Th1 responses are associated with vaccine-induced protection against SARS-CoV-2 infection in patients with hematological malignancies

Author

Bigenwald, Camille, primary, Haddad, Yacine, additional, Thelemaque, Cassandra, additional, Carrier, Agathe, additional, Birebent, Roxanne, additional, Ly, Pierre, additional, Flament, Caroline, additional, Lahmar, Imran, additional, de Sousa, Eric, additional, Maeurer, Markus, additional, Miyara, Makoto, additional, Assi, Tarek, additional, Castilla-Llorente, Cristina, additional, Willekens, Christophe, additional, Fayemi, Céline, additional, Lazarovici, Julien, additional, Marabelle, Aurélien, additional, Derosa, Lisa, additional, Ribrag, Vincent, additional, and Zitvogel, Laurence, additional

Published
2023
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20. Outcomes and prognostic factors for relapsed or refractory lymphoma patients in phase I clinical trials

Author

Michot, Jean-Marie, Benajiba, Lina, Faivre, Laura, Baldini, Capucine, Haddag, Lelia, Bonnet, Clement, Massard, Christophe, Bigot, Frederic, Bigenwald, Camille, Verret, Benjamin, Thomas, Zoé A. P., Varga, Andrea, Gazzah, Anas, Hollebecque, Antoine, Ghez, David, Lazarovici, Julien, Balheda, Rastilav, Jeanson, Aurore, Postel-Vinay, Sophie, Danu, Alina, Soria, Jean-Charles, Paoletti, Xavier, and Ribrag, Vincent

Published
2017
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22. Sequence analyses of relapsed or refractory diffuse large B‐cell lymphomas unravel three genetic subgroups of patients and the GNA13 mutant as poor prognostic biomarker, results of LNH‐EP1 study.

Author

Michot, Jean‐Marie, Quivoron, Cyril, Sarkozy, Clémentine, Danu, Alina, Lazarovici, Julien, Saleh, Khalil, El‐Dakdouki, Yolla, Goldschmidt, Vincent, Bigenwald, Camille, Dragani, Matteo, Bahleda, Rastislav, Baldini, Capucine, Arfi‐Rouche, Julia, Martin‐Romano, Patricia, Tselikas, Lambros, Gazzah, Anas, Hollebecque, Antoine, Lacroix, Ludovic, Ghez, David, and Vergé, Veronique

Published
2023
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23. Sequence Analyses of Relapsed or Refractory Diffuse Large B-Cell Lymphomas Unravels Three Genetic Subgroups of Patients and GNA3 Mutant as Poor Prognosis Biomarker, Results of LNH-EP1 Study

Author

Michot, Jean-Marie, primary, Quivoron, Cyril, additional, Sarkozy, Clémentine, additional, Danu, Alina, additional, Lazarovici, Julien, additional, Saleh, Khalil, additional, El-Dakdouki, Yolla, additional, Goldschmidt, Vincent, additional, Bigenwald, Camille, additional, Dragani, Matteo, additional, Bahleda, Rastislav, additional, Baldini, Capucine, additional, Arfi-Rouche, Julia, additional, Martin-Romano, Patricia, additional, Tselikas, Lambros, additional, Gazzah, Anas, additional, Hollebecque, Antoine, additional, Lacroix, Ludovic, additional, Ghez, David, additional, Vergé, Veronique, additional, Marzac, Christophe, additional, Cotteret, Sophie, additional, Rahali, Wassila, additional, Soria, Jean-Charles, additional, Massard, Christophe, additional, Bernard, Olivier A., additional, Dartigues, Peggy, additional, Camara-Clayette, Valérie, additional, and Ribrag, Vincent, additional

Published
2022
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24. CD8+ T Lymphocytes Immune Depletion and LAG-3 Overexpression in Hodgkin Lymphoma Tumor Microenvironment Exposed to Anti-PD-1 Immunotherapy

Author

Michot, Jean-Marie, primary, Mouraud, Severine, additional, Adam, Julien, additional, Lazarovici, Julien, additional, Bigenwald, Camille, additional, Rigaud, Charlotte, additional, Tselikas, Lambros, additional, Dartigues, Peggy, additional, Danu, Alina, additional, Bigorgne, Amélie, additional, Minard, Veronique, additional, Ghez, David, additional, Marabelle, Aurélien, additional, Zitvogel, Laurence, additional, and Ribrag, Vincent, additional

Published
2021
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26. BRAF V600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

Author

Bigenwald, Camille, Le Berichel, Jessica, Wilk, C Matthias, Chakraborty, Rikhia, Chen, Steven T, Tabachnikova, Alexandra, Mancusi, Rebecca, Abhyankar, Harshal, Casanova-Acebes, Maria, Laface, Ilaria, Akturk, Guray, Jobson, Jenielle, Karoulia, Zoi, Martin, Jerome C, Grout, John, Rafiei, Anahita, Lin, Howard, Manz, Markus G, Baccarini, Alessia, Poulikakos, Poulikos I, Brown, Brian D, Gnjatic, Sacha, Lujambio, Amaia, McClain, Kenneth L, Picarsic, Jennifer, Allen, Carl E, Merad, Miriam, University of Zurich, and Merad, Miriam

Subjects
1300 General Biochemistry, Genetics and Molecular Biology, 10032 Clinic for Oncology and Hematology, 610 Medicine & health
Published
2021

28. Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH

Author

Sengal, Amel, primary, Velazquez, Jessica, additional, Hahne, Meryl, additional, Burke, Thomas M., additional, Abhyankar, Harshal, additional, Reyes, Robert, additional, Olea, Walter, additional, Scull, Brooks, additional, Eckstein, Olive S., additional, Bigenwald, Camille, additional, Bollard, Catherine M., additional, Yu, Wendong, additional, Merad, Miriam, additional, McClain, Kenneth L., additional, Allen, Carl E., additional, and Chakraborty, Rikhia, additional

Published
2021
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29. Clinical significance of the loss of CD20 antigen on tumor cells in patients with relapsed or refractory follicular lymphoma

Author

Michot, Jean-Marie, primary, Buet-Elfassy, Alice, additional, Annereau, Maxime, additional, Lazarovici, Julien, additional, Danu, Alina, additional, Sarkozy, Clémentine, additional, Chahine, Claude, additional, Bigenwald, Camille, additional, Bosq, Jacques, additional, Rossignol, Julien, additional, Romano-Martin, Patricia, additional, Baldini, Capucine, additional, Ghez, David, additional, Dartigues, Peggy, additional, Massard, Christophe, additional, and Ribrag, Vincent, additional

Published
2021
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30. Human Microbial Transplant Restores T Cell Cytotoxicity and Anti-Tumor Response to PD-L1 Blockade in Gnotobiotic Mice

Author

Borgerding, Joshua N., primary, Shang, Joan, additional, Britton, Graham J., additional, Salmon, Hélène, additional, Bigenwald, Camille, additional, Maier, Barbara, additional, Rose, Samuel R., additional, Mogno, Ilaria, additional, Kamphorst, Alice O., additional, Merad, Miriam, additional, and Faith, Jeremiah J., additional

Published
2020
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31. Blocking MAPK Activation and Immune Checkpoints Reverse Immune Dysfunction and Reduce Disease in a Mouse Model of LCH

Author

Sengal, Amel, primary, Hahne, Meryl, additional, Velasquez, Jessica, additional, Abhyankar, Harshal, additional, Burke, Thomas, additional, Olea, Walter, additional, Reyes, Robert, additional, Scull, Brooks, additional, Bigenwald, Camille, additional, Bollard, Catherine M., additional, Yu, Wendong, additional, Merad, Miriam, additional, McClain, Kenneth L., additional, Allen, Carl E., additional, and Chakraborty, Rikhia, additional

Published
2019
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33. 1-Year Data Analysis from a Cancer Center Molecular Tumor Board Dedicated to Clonal Hematopoiesis

Author

Micol, Jean-Baptiste, Arbab, Ahmadreza, Vasseur, Damien, Bayle, Arnaud, Aldea, Mihaela, Loyaux, Romain, Verge, Veronique, Saada, Veronique, Fievet, Alice, Auger, Nathalie, Cotteret, Sophie, Pasquier, Florence, Willekens, Christophe, Bigenwald, Camille, Castilla-Llorente, Cristina, De Botton, Stephane, Solary, Eric, Bernard, Elsa, Rouleau, Etienne, Italiano, Antoine, Marzac, Christophe, and Renneville, Aline

Abstract

Background

Published
2023
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34. A comprehensive analysis of Lymphoma-associated haemophagocytic syndrome in a large French multicentre cohort detects some clues to improve prognosis

Author

Bigenwald, Camille, primary, Fardet, Laurence, additional, Coppo, Paul, additional, Meignin, Véronique, additional, Lazure, Thierry, additional, Fabiani, Bettina, additional, Kohn, Milena, additional, Oksenhendler, Eric, additional, Boutboul, David, additional, Uzzan, Mathieu, additional, Lambotte, Olivier, additional, and Galicier, Lionel, additional

Published
2018
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36. RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Author

Hogstad, Brandon, primary, Berres, Marie-Luise, additional, Chakraborty, Rikhia, additional, Tang, Jun, additional, Bigenwald, Camille, additional, Serasinghe, Madhavika, additional, Lim, Karen Phaik Har, additional, Lin, Howard, additional, Man, Tsz-Kwong, additional, Remark, Romain, additional, Baxter, Samantha, additional, Kana, Veronika, additional, Jordan, Stefan, additional, Karoulia, Zoi, additional, Kwan, Wing-hong, additional, Leboeuf, Marylene, additional, Brandt, Elisa, additional, Salmon, Helene, additional, McClain, Kenneth, additional, Poulikakos, Poulikos, additional, Chipuk, Jerry, additional, Mulder, Willem J.M., additional, Allen, Carl E., additional, and Merad, Miriam, additional

Published
2017
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38. Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Author

Lavin, Yonit, primary, Kobayashi, Soma, additional, Leader, Andrew, additional, Amir, El-ad David, additional, Elefant, Naama, additional, Bigenwald, Camille, additional, Remark, Romain, additional, Sweeney, Robert, additional, Becker, Christian D., additional, Levine, Jacob H., additional, Meinhof, Klaus, additional, Chow, Andrew, additional, Kim-Shulze, Seunghee, additional, Wolf, Andrea, additional, Medaglia, Chiara, additional, Li, Hanjie, additional, Rytlewski, Julie A., additional, Emerson, Ryan O., additional, Solovyov, Alexander, additional, Greenbaum, Benjamin D., additional, Sanders, Catherine, additional, Vignali, Marissa, additional, Beasley, Mary Beth, additional, Flores, Raja, additional, Gnjatic, Sacha, additional, Pe’er, Dana, additional, Rahman, Adeeb, additional, Amit, Ido, additional, and Merad, Miriam, additional

Published
2017
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40. Are myelodysplastic syndromes and acute myeloid leukaemia occurring during the course of lymphoma always therapy related?

Author

Bigenwald, Camille, primary, Harel, Stéphanie, additional, Chevignon, Florian, additional, Roos-Weil, Damien, additional, Bernard, Olivier A., additional, Amorim, Sandy, additional, Brice, Pauline, additional, Adès, Lionel, additional, Nloga, Anne Marie, additional, Sébert, Marie, additional, Braun, Thorsten, additional, Eclache, Virginie, additional, Thieblemont, Catherine, additional, and Fenaux, Pierre, additional

Published
2016
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41. Are Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) Occurring during the Course of Lymphoma (Ly) Always Therapy Related?

Author

Bigenwald, Camille, primary, Harel, Stephanie, additional, Chevillon, Florian, additional, Roos-Weil, Damien, additional, Bernard, Olivier A., additional, Amorim, Sandy, additional, Brice, Pauline, additional, Lionel, Ades, additional, Nloga, Anne Marie, additional, Sébert, Marie, additional, Braun, Thorsten, additional, Eclache, Virginie, additional, Thieblemont, Catherine, additional, and Fenaux, Pierre, additional

Published
2015
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42. Outcomes and prognostic factors for relapsed or refractory lymphoma patients in phase I clinical trials.

Author

Michot, Jean-Marie, Benajiba, Lina, Faivre, Laura, Baldini, Capucine, Haddag, Lelia, Bonnet, Clement, Massard, Christophe, Bigot, Frederic, Bigenwald, Camille, Verret, Benjamin, Thomas, Zoé A. P., Varga, Andrea, Gazzah, Anas, Hollebecque, Antoine, Ghez, David, Lazarovici, Julien, Balheda, Rastilav, Jeanson, Aurore, Postel-Vinay, Sophie, and Danu, Alina

Subjects
LYMPHOMAS, CANCER relapse, CLINICAL trials, CONFIDENCE intervals, DRUG dosage, CLINICAL drug trials, DRUG toxicity, EVALUATION of medical care, PATIENT safety, RETROSPECTIVE studies, PROGNOSIS
Abstract

Background Although safety and prognostic factors for overall survival (OS) have been extensively studied in Phase I clinical trials on patients with solid tumours, data on lymphoma trials are scarce. Here, we investigated safety, outcomes and prognostic factors in relapsed or refractory lymphoma patients included in a series of Phase I trials. Method and patients All consecutive adult patients with recurrent/refractory lymphoma enrolled in 26 Phase I trials at a single cancer centre in France between January 2008 and June 2016 were retrospectively assessed. Results 133 patients (males: 65%) were included in the analysis. The median (range) age was 65 (23–86). Aggressive non-Hodgkin, indolent non-Hodgkin and Hodgkin types accounted for 64%, 25% and 11% of the patients, respectively. The patients had received a median (range) of 3 (1–13) lines of treatment prior to trial entry. The median [95% confidence interval] progression-free survival and OS times were 3.0 [1.8–3.6] and 17.8 [12.7–30.4] months, respectively. High-grade toxicity (grade 3 or higher, according to the National Cancer Institute’s Common Terminology Criteria for Adverse Events classification) was experienced by 56 of the 133 patients (42%) and was related to the investigational drug in 44 of these cases (79%). No toxicity-related deaths occurred. Dose-limiting toxicity (DLT) was encountered in 11 (9%) of the 116 evaluable patients. High-grade toxicity occurred during the DLT period for 34 of the 56 patients (61%) and after the DLT period in the remaining 22 (39%). The main prognostic factors for poor OS were the histological type (i.e. tumour aggressiveness), an elevated serum LDH level, and a low serum albumin level. Early withdrawal from a trial was correlated with the performance status score, the histological type and the serum LDH level. The overall objective response and disease control rates were 24% and 57%, respectively. Conclusion Performance status, LDH, albumin and histological type (tumour aggressiveness) appear to be the most relevant prognostic factors for enrolling Phase I participants with relapsed or refractory lymphoma. 39% of the patients experienced a first high-grade toxic event after the dose-limiting toxicity period, suggesting that the conventional concept of dose-limiting toxicity (designed for chemotherapy) should be redefined in the era of modern cancer therapies. [ABSTRACT FROM AUTHOR]

Published
2018
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43. Concurrent Radiation and ESHAP Regimen in Localized Extranodal NK/T-Cell Lymphoma Nasal Type, Phase II French Study

Author

Michot, Jean-Marie, primary, Girinsky, Theodore, additional, Danu, Alina, additional, Antosikova, Anna, additional, Ferme, Christophe, additional, Lazarovici, Julien, additional, Willekens, Christophe, additional, Chamseddine, Ali N, additional, Ghez, David, additional, Bigenwald, Camille, additional, Bosq, Jacques, additional, de Botton, Stephane, additional, Mazeron, Renaud, additional, and Ribrag, Vincent, additional

Published
2014
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44. A Simple Scoring System for Identifying Relapsed/Refractory Lymphoma Patients Prematurely Withdrawn from Phase I Trials: The Gustave Roussy Experience

Author

Benajiba, Lina, primary, Baldini, Capucine, additional, Faivre, Laura, additional, Michot, Jean-Marie, additional, Varga, Andrea, additional, Willekens, Christophe, additional, Bigenwald, Camille, additional, Bahleda, Rastislav, additional, Gazzah, Anas, additional, Soria, Jean-Charles, additional, and Ribrag, Vincent, additional

Published
2014
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46. RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

Author

Hogstad, Brandon, Berres, Marie-Luise, Chakraborty, Rikhia, Tang, Jun, Bigenwald, Camille, Serasinghe, Madhavika, Lim, Karen Phaik Har, Lin, Howard, Man, Tsz-Kwong, Remark, Romain, Baxter, Samantha, Kana, Veronika, Jordan, Stefan, Karoulia, Zoi, Kwan, Wing-hong, Leboeuf, Marylene, Brandt, Elisa, Salmon, Helene, McClain, Kenneth, Poulikakos, Poulikos, Chipuk, Jerry, Mulder, Willem J.M., Allen, Carl E., and Merad, Miriam

Abstract

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately 60% of LCH patients harbor somatic BRAFV600E mutations localizing to CD207+ DCs within lesions. However, the mechanisms driving BRAFV600E+ LCH cell accumulation in lesions remain unknown. Here we show that sustained extracellular signal–related kinase activity induced by BRAFV600E inhibits C-C motif chemokine receptor 7 (CCR7)–mediated DC migration, trapping DCs in tissue lesions. Additionally, BRAFV600E increases expression of BCL2-like protein 1 (BCL2L1) in DCs, resulting in resistance to apoptosis. Pharmacological MAPK inhibition restores migration and apoptosis potential in a mouse LCH model, as well as in primary human LCH cells. We also demonstrate that MEK inhibitor-loaded nanoparticles have the capacity to concentrate drug delivery to phagocytic cells, significantly reducing off-target toxicity. Collectively, our results indicate that MAPK tightly suppresses DC migration and augments DC survival, rendering DCs in LCH lesions trapped and resistant to cell death.

Published
2018
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47. [Hematological toxicities post-CAR-T cells: Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Author

Alsuliman T, Aubrun C, Bay JO, Beguin Y, Bigenwald C, Brissot E, Chalandon Y, Chevallier P, Pagliuca S, Magro L, and Srour M

Abstract

Chimeric antigen receptor T cell (CAR-T cell) therapy has become a standard-of-care for several hematological and a promising treatment for solid malignancies or for selected non-malignant autoimmune disorders. Hematological complications following this treatment are very common with the majority of patients experiencing at least one cytopenia after CAR-T cell injections. The management of these adverse events is not standardized and represents an area of active research and unmet clinical needs. This harmonization workshop, gathering a group of experts who analyzed this topic, has been conceived for the optimization of the management of patients presenting with post-CAR-T cell hematological toxicities. Based on the data present in the literature, these practical recommendations were made to harmonize the practices of Francophone centers involved in the management of these patients., (Copyright © 2024 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)

Published
2024
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48. BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance.

Author

Zhao L, Liu P, Mao M, Zhang S, Bigenwald C, Dutertre CA, Lehmann CHK, Pan H, Paulhan N, Amon L, Buqué A, Yamazaki T, Galluzzi L, Kloeckner B, Silvin A, Pan Y, Chen H, Tian AL, Ly P, Dudziak D, Zitvogel L, Kepp O, and Kroemer G

Subjects
Humans, Animals, Mice, Dendritic Cells, Programmed Cell Death 1 Receptor, Monitoring, Immunologic, Mice, Knockout, Proto-Oncogene Proteins c-bcl-2 genetics, Neoplasms drug therapy, Neoplasms genetics, Antineoplastic Agents therapeutic use
Abstract

We developed a phenotypic screening platform for the functional exploration of dendritic cells (DC). Here, we report a genome-wide CRISPR screen that revealed BCL2 as an endogenous inhibitor of DC function. Knockout of BCL2 enhanced DC antigen presentation and activation as well as the capacity of DCs to control tumors and to synergize with PD-1 blockade. The pharmacologic BCL2 inhibitors venetoclax and navitoclax phenocopied these effects and caused a cDC1-dependent regression of orthotopic lung cancers and fibrosarcomas. Thus, solid tumors failed to respond to BCL2 inhibition in mice constitutively devoid of cDC1, and this was reversed by the infusion of DCs. Moreover, cDC1 depletion reduced the therapeutic efficacy of BCL2 inhibitors alone or in combination with PD-1 blockade and treatment with venetoclax caused cDC1 activation, both in mice and in patients. In conclusion, genetic and pharmacologic BCL2 inhibition unveils a DC-specific immune checkpoint that restrains tumor immunosurveillance., Significance: BCL2 inhibition improves the capacity of DCs to stimulate anticancer immunity and restrain cancer growth in an immunocompetent context but not in mice lacking cDC1 or mature T cells. This study indicates that BCL2 blockade can be used to sensitize solid cancers to PD-1/PD-L1-targeting immunotherapy. This article is featured in Selected Articles from This Issue, p. 2293., (©2023 American Association for Cancer Research.)

Published
2023
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49. The Polarity and Specificity of Antiviral T Lymphocyte Responses Determine Susceptibility to SARS-CoV-2 Infection in Patients with Cancer and Healthy Individuals.

Author

Fahrner JE, Lahmar I, Goubet AG, Haddad Y, Carrier A, Mazzenga M, Drubay D, Alves Costa Silva C, de Sousa E, Thelemaque C, Melenotte C, Dubuisson A, Geraud A, Ferrere G, Birebent R, Bigenwald C, Picard M, Cerbone L, Lérias JR, Laparra A, Bernard-Tessier A, Kloeckner B, Gazzano M, Danlos FX, Terrisse S, Pizzato E, Flament C, Ly P, Tartour E, Benhamouda N, Meziani L, Ahmed-Belkacem A, Miyara M, Gorochov G, Barlesi F, Trubert A, Ungar B, Estrada Y, Pradon C, Gallois E, Pommeret F, Colomba E, Lavaud P, Deloger M, Droin N, Deutsch E, Gachot B, Spano JP, Merad M, Scotté F, Marabelle A, Griscelli F, Blay JY, Soria JC, Merad M, André F, Villemonteix J, Chevalier MF, Caillat-Zucman S, Fenollar F, Guttman-Yassky E, Launay O, Kroemer G, La Scola B, Maeurer M, Derosa L, and Zitvogel L

Subjects
Antibodies, Neutralizing, Humans, SARS-CoV-2, Spike Glycoprotein, Coronavirus chemistry, Spike Glycoprotein, Coronavirus genetics, Antiviral Restriction Factors immunology, COVID-19 immunology, Neoplasms complications, T-Lymphocytes immunology
Abstract

Vaccination against coronavirus disease 2019 (COVID-19) relies on the in-depth understanding of protective immune responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We characterized the polarity and specificity of memory T cells directed against SARS-CoV-2 viral lysates and peptides to determine correlates with spontaneous, virus-elicited, or vaccine-induced protection against COVID-19 in disease-free and cancer-bearing individuals. A disbalance between type 1 and 2 cytokine release was associated with high susceptibility to COVID-19. Individuals susceptible to infection exhibited a specific deficit in the T helper 1/T cytotoxic 1 (Th1/Tc1) peptide repertoire affecting the receptor binding domain of the spike protein (S1-RBD), a hotspot of viral mutations. Current vaccines triggered Th1/Tc1 responses in only a fraction of all subject categories, more effectively against the original sequence of S1-RBD than that from viral variants. We speculate that the next generation of vaccines should elicit Th1/Tc1 T-cell responses against the S1-RBD domain of emerging viral variants., Significance: This study prospectively analyzed virus-specific T-cell correlates of protection against COVID-19 in healthy and cancer-bearing individuals. A disbalance between Th1/Th2 recall responses conferred susceptibility to COVID-19 in both populations, coinciding with selective defects in Th1 recognition of the receptor binding domain of spike. See related commentary by McGary and Vardhana, p. 892. This article is highlighted in the In This Issue feature, p. 873., (©2022 The Authors; Published by the American Association for Cancer Research.)

Published
2022
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