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3. Evolution of Plasmodium falciparum antimalarial drug resistance markers post-adoption of artemisinin-based combination therapies in Yaounde, Cameroon

Author

Niba, Peter Thelma Ngwa, Nji, Akindeh Mbuh, Chedjou, Jean Paul Kengne, Hansson, Helle, Hocke, Emma Filtenborg, Ali, Innocent Mbulli, Achonduh-Atijegbe, Olivia, Evehe, Marie-Solange B., Jørgensen, Marie Helene Munck, Fomboh, Calvino Tah, Cui, Liwang, Stresman, Gillian, Bigoga, Jude D., Alifrangis, Michael, and Mbacham, Wilfred F.

Published
2023
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4. Systematic review and meta-analysis of maternal and fetal outcomes among pregnant women with bacterial vaginosis

Author

Kenfack-Zanguim, Josiane, Kenmoe, Sebastien, Bowo-Ngandji, Arnol, Kenfack-Momo, Raoul, Thierry Ebogo-Belobo, Jean, Kengne-Ndé, Cyprien, Serge Mbaga, Donatien, Zeuko'o Menkem, Elisabeth, Lontuo Fogang, Robertine, Tchatchouang, Serges, Laure Ndzie Ondigui, Juliette, Irma Kame-Ngasse, Ginette, Nina Magoudjou-Pekam, Jeannette, Roussel Takuissu, Guy, Nkie Esemu, Seraphine, Nantcho Clavela, Nguepgjio, Barriere Fodjo, Airy, Ndip, Lucy, Bigoga, Jude, Megnekou, Rosette, and Esemu, Livo F.

Published
2023
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5. Allelic frequencies of mutants of the Plasmodium falciparum, quinoline and folate metabolizing genes in the west region of Cameroon

Author

Ali, Innocent Mbulli, Tchuenkam, Valery Pacome Kom, Tagomo, Sandra Sob, Mawamba, Hornela, Moyeh, Marcel Nyuylam, Nfor, Emmanuel Nfor, Nji, Akindeh Mbuh, Fomboh, Calvino Tah, Nana, William Dorian, Kengne, Jean-Paul Chedjou, Niba, Peter Thelma Ngwa, Ekoyol, Germaine Ekobo, Achu, Dorothy Fosah, Bigoga, Jude Daiga, and Mbacham, Wilfred Fon

Published
2022
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7. Effectiveness and safety of artesunate–amodiaquine versus artemether–lumefantrine for home-based treatment of uncomplicated Plasmodium falciparum malaria among children 6–120 months in Yaoundé, Cameroon: a randomized trial

Author

Niba, Peter Thelma Ngwa, Nji, Akindeh Mbuh, Ali, Innocent Mbulli, Akam, Lawrence Fonyonga, Dongmo, Cedric Hermann, Chedjou, Jean Paul Kengne, Fomboh, Calvino Tah, Nana, William Dorian, Oben, Ornella Laetitia Ayem, Selly-Ngaloumo, Abdel Aziz, Moyeh, Marcel N., Ngu, Jude Achidi, Ludovic, Ambassa Jean, Aboh, Pierre Martiniel, Ambani, Marie Carine Enyegue, Omgba, Pierrette Albertine Mbarga, Kotcholi, Grâce Bissohong, Adzemye, Linus Moye, Nna, Danielle Regine Abenkou, Douanla, Adèle, Ango, Ze, Ewane, Marie Sophie, Ticha, Joel Tewara, Tatah, Fritz Mbuh, Dinza, Golwa, Ndikum, Valentine Nchafor, Fosah, Dorothy A., Bigoga, Jude D., Alifrangis, Michael, and Mbacham, Wilfred F.

Published
2022
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8. Assessing the performance of five adult mosquito sampling methods for malaria vector surveillance in various ecosystems in Cameroon

Author

Nwane, Philippe, primary, Piameu, Michael, additional, Emalio, Yannick Niamsi, additional, Ekoko, Wolfgang Eyisap, additional, Mandeng, Stanislas Elysée, additional, Mbakop, Lili Ranaise, additional, Patchoke, Salomon, additional, Toto, Jean-Claude, additional, Alenou, Leo Dilane, additional, Bikoi, Elisabeth Ngo, additional, Onguina, Hugues, additional, Nvondo, Narcisse, additional, Mimpfoundi, Remy, additional, Tabue, Raymond, additional, Bigoga, Jude, additional, Fondjo, Etienne, additional, Awono-Ambene, Parfait, additional, and Etang, Josiane, additional

Published
2024
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9. Comparative Diagnostic Performance of Microscopy, SD-Bioline Rapid Diagnostic Test, and Polymerase Chain Reaction in the Detection of Malaria Infection among Pregnant Women at Delivery in Kumba Health District Area in the Southwest Region of Cameroon

Author

Ngemani Obase, Bekindaka, primary, Livo Forgu, Esemu, additional, Honore Awanakam, Awanakam, additional, Francis, Zeukeng, additional, Balonga Annie, Agnenga, additional, Loic, Nchankou, additional, Daiga Bigoga, Jude, additional, Leke, Rose, additional, and Nsagha, Dickson Shey, additional

Published
2023
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11. PA-595 Hepatotoxicity associated to N-Acetyltransferase type 2 polymorphisms in TB patients with malaria at Jamot Hospital, Yaoundé, Cameroon

Author

Tiani, Lionel Ulrich, primary, Axel Cyriaque, AMBASSA, additional, Assam Assam, Jean Paul, additional, Andorseh, Genevieve, additional, Thiomo, Diane Kamdem, additional, Fossi, Cedric Tchinda, additional, Numfor, Nkah Leonard, additional, Kamga, Hortense Gonsu, additional, Kouanfack, Charles, additional, Pefura Yone, Eric Walters, additional, Bigoga, Jude Daiga, additional, Ntoumi, Francine, additional, and Beng, Véronique Penlap, additional

Published
2023
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12. PA-845 Cross-reactive anti-SARS-CoV-2 antibody detected in plasma from pre-COVID-19 pregnant women in Yaoundé are not neutralizing

Author

Medouen Reine, Seumko’o Ndeumou, primary, Sosthène Hillary, Matabou Tene, additional, Benderli, Nana Christine, additional, Philomena, Gwanmesia, additional, Mfuh, Obadia Kenji, additional, Michael, Besong, additional, Bernard Marie, Bitye Zambo, additional, Chris Marco, Nana Mbianda, additional, Roméo Brice, Djounda Dieffouo, additional, Daiga, Bigoga Jude, additional, Elvine Ginette, Edoul Mbesse, additional, Khan, Khadija, additional, Reedoy, Kajal, additional, Alex, Sigal, additional, Leke Rose, Gana Fomban, additional, Rosette, Megnekou, additional, and Livo, Esemu Forgu, additional

Published
2023
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15. Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Author

Niba, Peter Thelma Ngwa, Nji, Akindeh M., Evehe, Marie-Solange, Ali, Innocent M., Netongo, Palmer Masumbe, Ngwafor, Randolph, Moyeh, Marcel N., Ngum, Lesley Ngum, Ndum, Oliva Ebie, Acho, Fon Abongwa, Mbu’u, Cyrille Mbanwi, Fosah, Dorothy A., Atogho-Tiedeu, Barbara, Achonduh-Atijegbe, Olivia, Djokam-Dadjeu, Rosine, Chedjou, Jean Paul Kengne, Bigoga, Jude D., Moukoko, Carole Else Eboumbou, Ajua, Anthony, Achidi, Eric, Tallah, Esther, Leke, Rose G. F., Tourgordi, Alexis, Ringwald, Pascal, Alifrangis, Michael, and Mbacham, Wilfred F.

Published
2021
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17. Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: a WHO-coordinated, prospective, international, observational cohort study

Author

Kleinschmidt, Immo, Bradley, John, Knox, Tessa Bellamy, Mnzava, Abraham Peter, Kafy, Hmooda Toto, Mbogo, Charles, Ismail, Bashir Adam, Bigoga, Jude D, Adechoubou, Alioun, Raghavendra, Kamaraju, Cook, Jackie, Malik, Elfatih M, Nkuni, Zinga José, Macdonald, Michael, Bayoh, Nabie, Ochomo, Eric, Fondjo, Etienne, Awono-Ambene, Herman Parfait, Etang, Josiane, Akogbeto, Martin, Bhatt, Rajendra M, Chourasia, Mehul Kumar, Swain, Dipak K, Kinyari, Teresa, Subramaniam, Krishanthi, Massougbodji, Achille, Okê-Sopoh, Mariam, Ogouyemi-Hounto, Aurore, Kouambeng, Celestin, Abdin, Mujahid Sheikhedin, West, Philippa, Elmardi, Khalid, Cornelie, Sylvie, Corbel, Vincent, Valecha, Neena, Mathenge, Evan, Kamau, Luna, Lines, Jonathan, and Donnelly, Martin James

Published
2018
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19. Pyronaridine-artesunate real-world safety, tolerability, and effectiveness in malaria patients in 5 African countries: A single-arm, open-label, cohort event monitoring study

Author

Tona Lutete, Gaston, Mombo-Ngoma, Ghyslain, Assi, Serge-Brice, Bigoga, Jude D., Koukouikila-Koussounda, Felix, Ntamabyaliro, Nsengi Y., Ntoumi, Francine, Agnandji, Selidji T., Groger, Mirjam, Shin, Jangsik, Borghini-Fuhrer, Isabelle, Arbe-Barnes, Sarah, Allen, Stephen J., Kremsner, Peter G., Miller, Robert, Duparc, Stephan, and Ramharter, Michael

Subjects
Antimalarials -- Dosage and administration -- Patient outcomes, Drug therapy, Combination -- Methods -- Patient outcomes, Malaria -- Drug therapy -- Patient outcomes, Biological sciences
Abstract

Background In Phase II/III randomized controlled clinical trials for the treatment of acute uncomplicated malaria, pyronaridine-artesunate demonstrated high efficacy and a safety profile consistent with that of comparators, except that asymptomatic, mainly mild-to-moderate transient increases in liver aminotransferases were reported for some patients. Hepatic safety, tolerability, and effectiveness have not been previously assessed under real-world conditions in Africa. Methods and findings This single-arm, open-label, cohort event monitoring study was conducted at 6 health centers in Cameroon, Democratic Republic of Congo, Gabon, Ivory Coast, and Republic of Congo between June 2017 and April 2019. The trial protocol as closely as possible resembled real-world clinical practice for the treatment of malaria at the centers. Eligible patients were adults or children of either sex, weighing at least 5 kg, with acute uncomplicated malaria who did not have contraindications for pyronaridine-artesunate treatment as per the summary of product characteristics. Patients received fixed-dose pyronaridine-artesunate once daily for 3 days, dosed by body weight, without regard to food intake. A tablet formulation was used in adults and adolescents and a pediatric granule formulation in children and infants under 20 kg body weight. The primary outcome was the hepatic event incidence, defined as the appearance of the clinical signs and symptoms of hepatotoxicity confirmed by a >2x rise in alanine aminotransferase/aspartate aminotransferase (ALT/AST) versus baseline in patients with baseline ALT/AST >2x the upper limit of normal (ULN). As a secondary outcome, this was assessed in patients with ALT/AST >2x ULN prior to treatment versus a matched cohort of patients with normal baseline ALT/AST. The safety population comprised 7,154 patients, of mean age 13.9 years (standard deviation (SD) 14.6), around half of whom were male (3,569 [49.9%]). Patients experienced 8,560 malaria episodes; 158 occurred in patients with baseline ALT/AST elevations >2xULN. No protocol-defined hepatic events occurred following pyronaridine-artesunate treatment of malaria patients with or without baseline hepatic dysfunction. Thus, no cohort comparison could be undertaken. Also, as postbaseline clinical chemistry was only performed where clinically indicated, postbaseline ALT/AST levels were not systematically assessed for all patients. Adverse events of any cause occurred in 20.8% (1,490/7,154) of patients, most frequently pyrexia (5.1% [366/7,154]) and vomiting (4.2% [303/7,154]). Adjusting for Plasmodium falciparum reinfection, clinical effectiveness at day 28 was 98.6% ([7,369/7,746] 95% confidence interval (CI) 98.3 to 98.9) in the per-protocol population. There was no indication that comorbidities or malnutrition adversely affected outcomes. The key study limitation was that postbaseline clinical biochemistry was only evaluated when clinically indicated. Conclusions Pyronaridine-artesunate had good tolerability and effectiveness in a representative African population under conditions similar to everyday clinical practice. These findings support pyronaridine-artesunate as an operationally useful addition to the management of acute uncomplicated malaria. Trial registration ClinicalTrials.gov NCT03201770., Author(s): Gaston Tona Lutete 1, Ghyslain Mombo-Ngoma 2,3,4, Serge-Brice Assi 5, Jude D. Bigoga 6, Felix Koukouikila-Koussounda 7, Nsengi Y. Ntamabyaliro 1, Francine Ntoumi 3,7, Selidji T. Agnandji 2,3, Mirjam [...]

Published
2021
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22. Patterns of anopheline feeding/resting behaviour and Plasmodium infections in North Cameroon, 2011–2014: implications for malaria control

Author

Ekoko, Wolfgang Eyisap, Awono-Ambene, Parfait, Bigoga, Jude, Mandeng, Stanislas, Piameu, Michael, Nvondo, Narcisse, Toto, Jean-Claude, Nwane, Philippe, Patchoke, Salomon, Mbakop, Lili Ranaise, Binyang, Jerome Achille, Donelly, Martin, Kleinschmidt, Immo, Knox, Tessa, Mbida, Arthur Mbida, Dongmo, Alain, Fondjo, Etienne, Mnzava, Abraham, and Etang, Josiane

Published
2019
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26. Effectiveness and safety of artesunate–amodiaquine versus artemether–lumefantrine for home-based treatment of uncomplicated Plasmodium falciparum malaria among children 6–120 months in Yaoundé, Cameroon:a randomized trial

Author

Niba, Peter Thelma Ngwa, Nji, Akindeh Mbuh, Ali, Innocent Mbulli, Akam, Lawrence Fonyonga, Dongmo, Cedric Hermann, Chedjou, Jean Paul Kengne, Fomboh, Calvino Tah, Nana, William Dorian, Oben, Ornella Laetitia Ayem, Selly-Ngaloumo, Abdel Aziz, Moyeh, Marcel N., Ngu, Jude Achidi, Ludovic, Ambassa Jean, Aboh, Pierre Martiniel, Ambani, Marie Carine Enyegue, Omgba, Pierrette Albertine Mbarga, Kotcholi, Grâce Bissohong, Adzemye, Linus Moye, Nna, Danielle Regine Abenkou, Douanla, Adèle, Ango, Ze, Ewane, Marie Sophie, Ticha, Joel Tewara, Tatah, Fritz Mbuh, Dinza, Golwa, Ndikum, Valentine Nchafor, Fosah, Dorothy A., Bigoga, Jude D., Alifrangis, Michael, Mbacham, Wilfred F., Niba, Peter Thelma Ngwa, Nji, Akindeh Mbuh, Ali, Innocent Mbulli, Akam, Lawrence Fonyonga, Dongmo, Cedric Hermann, Chedjou, Jean Paul Kengne, Fomboh, Calvino Tah, Nana, William Dorian, Oben, Ornella Laetitia Ayem, Selly-Ngaloumo, Abdel Aziz, Moyeh, Marcel N., Ngu, Jude Achidi, Ludovic, Ambassa Jean, Aboh, Pierre Martiniel, Ambani, Marie Carine Enyegue, Omgba, Pierrette Albertine Mbarga, Kotcholi, Grâce Bissohong, Adzemye, Linus Moye, Nna, Danielle Regine Abenkou, Douanla, Adèle, Ango, Ze, Ewane, Marie Sophie, Ticha, Joel Tewara, Tatah, Fritz Mbuh, Dinza, Golwa, Ndikum, Valentine Nchafor, Fosah, Dorothy A., Bigoga, Jude D., Alifrangis, Michael, and Mbacham, Wilfred F.

Abstract

Background: Many studies have reported high efficacy and safety of artesunate-amodiaquine (AS-AQ) and artemether-lumefantrine (AL) when administered under direct observation in Cameroon. There is paucity of data to support their continuous use in home-based treatment of uncomplicated Plasmodium falciparum malaria in Cameroon. Hence, this study aimed to assess the effectiveness and safety of AS-AQ versus AL for home-based treatment of uncomplicated P. falciparum malaria among children 6–120 months in Yaoundé, Cameroon. Methods: A two-arm, open-label, randomized, controlled trial comparing the equivalence of AS-AQ (experimental group) and AL (control group) was carried out from May 2019 to April 2020 at two secondary hospitals in Yaoundé. Participants were randomized to receive either AS-AQ or AL. After the first dose, antimalarial drugs were given at home, rather than under direct observation by a study staff. The conventional on-treatment and post-treatment laboratory and clinical evaluations were not done until day 3 of the full antimalarial treatment course. The evaluation of effectiveness was mainly based on per protocol polymerase chain reaction adjusted adequate clinical and parasitological response (PP PCR adjusted ACPR) on day 28 post-treatment. Safety was based on assessment of adverse events (AEs) and severe adverse events (SAEs) from day 1 to day 28. Results: A total of 242 children were randomized to receive AS-AQ (n = 114) and AL (n = 128). The PP PCR adjusted day 28 cure rates were [AS-AQ = 96.9% (95% CI, 91.2–99.4) versus AL = 95.5% (95% CI, 89.9–98.5), P = 0.797]. Expected mild to moderate adverse events were reported in both arms [AS-AQ = 83 (84.7%) versus AL = 99 (86.1%), P = 0.774]. The most common adverse events included: transient changes of hematologic indices and fever. Conclusions: This study demonstrated that AS-AQ and AL are effective and safe for home management of malaria in Yaoundé. The evidence from this study supports the parallel us

Published
2022

28. Expression profiles of miR3181 and miR199a in plasma and placenta of virally suppressed HIV-1 infected Cameroonian pregnant women at delivery

Author

Esemu, Livo F., primary, Awanakam, Honore, additional, Nanfa, Dieudonne, additional, Besong, Michael, additional, Tsayem, Idriss, additional, Nkenfou, Celine Nguefeu, additional, Bigoga, Jude, additional, Leke, Rose, additional, Eugene, Sobngwi, additional, Ndhlovu, Lishomwa C., additional, and Loni, Gabriel Ekali, additional

Published
2022
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29. Resting Behaviour of Deltamethrin-Resistant Malaria Vectors, Anopheles arabiensis and Anopheles coluzzii, from North Cameroon: Upshots from a Two-Level Ordinary Logit Model

Author

Etang, Josiane, primary, Nono, Betrand Fesuh, additional, Awono-Ambene, Parfait, additional, Bigoga, Jude, additional, Eyisap, Wolfgang Ekoko, additional, Piameu, Michael, additional, Toto, Jean-Claude, additional, Nguema, Eugene Patrice Ndong, additional, Gwet, Henri, additional, Fondjo, Etienne, additional, and Mnzawa, Abraham Peter, additional

Published
2016
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30. Additional file 4 of Effectiveness and safety of artesunate���amodiaquine versus artemether���lumefantrine for home-based treatment of uncomplicated Plasmodium falciparum malaria among children 6���120 months in Yaound��, Cameroon: a randomized trial

Author

Niba, Peter Thelma Ngwa, Nji, Akindeh Mbuh, Ali, Innocent Mbulli, Akam, Lawrence Fonyonga, Dongmo, Cedric Hermann, Chedjou, Jean Paul Kengne, Fomboh, Calvino Tah, Nana, William Dorian, Oben, Ornella Laetitia Ayem, Selly-Ngaloumo, Abdel Aziz, Moyeh, Marcel N., Ngu, Jude Achidi, Ludovic, Ambassa Jean, Aboh, Pierre Martiniel, Ambani, Marie Carine Enyegue, Omgba, Pierrette Albertine Mbarga, Kotcholi, Gr��ce Bissohong, Adzemye, Linus Moye, Nna, Danielle Regine Abenkou, Douanla, Ad��le, Ango, Ze, Ewane, Marie Sophie, Ticha, Joel Tewara, Tatah, Fritz Mbuh, Dinza, Golwa, Ndikum, Valentine Nchafor, Fosah, Dorothy A., Bigoga, Jude D., Alifrangis, Michael, and Mbacham, Wilfred F.

Abstract

Additional file 4: Evolution of biological parameters among study participants treated with AS-AQ and AL (Day 0 and Day 7) (PP)

Published
2022
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31. Additional file 1 of Effectiveness and safety of artesunate���amodiaquine versus artemether���lumefantrine for home-based treatment of uncomplicated Plasmodium falciparum malaria among children 6���120 months in Yaound��, Cameroon: a randomized trial

Author

Niba, Peter Thelma Ngwa, Nji, Akindeh Mbuh, Ali, Innocent Mbulli, Akam, Lawrence Fonyonga, Dongmo, Cedric Hermann, Chedjou, Jean Paul Kengne, Fomboh, Calvino Tah, Nana, William Dorian, Oben, Ornella Laetitia Ayem, Selly-Ngaloumo, Abdel Aziz, Moyeh, Marcel N., Ngu, Jude Achidi, Ludovic, Ambassa Jean, Aboh, Pierre Martiniel, Ambani, Marie Carine Enyegue, Omgba, Pierrette Albertine Mbarga, Kotcholi, Gr��ce Bissohong, Adzemye, Linus Moye, Nna, Danielle Regine Abenkou, Douanla, Ad��le, Ango, Ze, Ewane, Marie Sophie, Ticha, Joel Tewara, Tatah, Fritz Mbuh, Dinza, Golwa, Ndikum, Valentine Nchafor, Fosah, Dorothy A., Bigoga, Jude D., Alifrangis, Michael, and Mbacham, Wilfred F.

Abstract

Additional file 1: Study treatment

Published
2022
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32. Additional file 3 of Effectiveness and safety of artesunate���amodiaquine versus artemether���lumefantrine for home-based treatment of uncomplicated Plasmodium falciparum malaria among children 6���120 months in Yaound��, Cameroon: a randomized trial

Author

Niba, Peter Thelma Ngwa, Nji, Akindeh Mbuh, Ali, Innocent Mbulli, Akam, Lawrence Fonyonga, Dongmo, Cedric Hermann, Chedjou, Jean Paul Kengne, Fomboh, Calvino Tah, Nana, William Dorian, Oben, Ornella Laetitia Ayem, Selly-Ngaloumo, Abdel Aziz, Moyeh, Marcel N., Ngu, Jude Achidi, Ludovic, Ambassa Jean, Aboh, Pierre Martiniel, Ambani, Marie Carine Enyegue, Omgba, Pierrette Albertine Mbarga, Kotcholi, Gr��ce Bissohong, Adzemye, Linus Moye, Nna, Danielle Regine Abenkou, Douanla, Ad��le, Ango, Ze, Ewane, Marie Sophie, Ticha, Joel Tewara, Tatah, Fritz Mbuh, Dinza, Golwa, Ndikum, Valentine Nchafor, Fosah, Dorothy A., Bigoga, Jude D., Alifrangis, Michael, and Mbacham, Wilfred F.

Abstract

Additional file 3: Kaplan���Meier survival curve for the effectiveness of AS-AQ versus AL (PP without and with PCR correction)

Published
2022
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33. Additional file 2 of Effectiveness and safety of artesunate���amodiaquine versus artemether���lumefantrine for home-based treatment of uncomplicated Plasmodium falciparum malaria among children 6���120 months in Yaound��, Cameroon: a randomized trial

Author

Niba, Peter Thelma Ngwa, Nji, Akindeh Mbuh, Ali, Innocent Mbulli, Akam, Lawrence Fonyonga, Dongmo, Cedric Hermann, Chedjou, Jean Paul Kengne, Fomboh, Calvino Tah, Nana, William Dorian, Oben, Ornella Laetitia Ayem, Selly-Ngaloumo, Abdel Aziz, Moyeh, Marcel N., Ngu, Jude Achidi, Ludovic, Ambassa Jean, Aboh, Pierre Martiniel, Ambani, Marie Carine Enyegue, Omgba, Pierrette Albertine Mbarga, Kotcholi, Gr��ce Bissohong, Adzemye, Linus Moye, Nna, Danielle Regine Abenkou, Douanla, Ad��le, Ango, Ze, Ewane, Marie Sophie, Ticha, Joel Tewara, Tatah, Fritz Mbuh, Dinza, Golwa, Ndikum, Valentine Nchafor, Fosah, Dorothy A., Bigoga, Jude D., Alifrangis, Michael, and Mbacham, Wilfred F.

Abstract

Additional file 2: Reference ranges of heart rate, systolic blood pressure, diastolic blood pressure, respiratory rate, hematology parameters and biochemistry parameters

Published
2022
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34. Patterns of Kdr-L995F Allele Emergence Alongside Detoxifying Enzymes Associated with Deltamethrin Resistance in Anopheles gambiae s.l. from North Cameroon

Author

Etang, Josiane, primary, Mandeng, Stanislas Elysée, additional, Nwane, Philippe, additional, Awono-Ambene, Herman Parfait, additional, Bigoga, Jude D., additional, Ekoko, Wolfgang Eyisap, additional, Binyang, Achille Jerome, additional, Piameu, Michael, additional, Mbakop, Lili Ranaise, additional, Mvondo, Narcisse, additional, Tabue, Raymond, additional, Mimpfoundi, Rémy, additional, Toto, Jean Claude, additional, Kleinschmidt, Immo, additional, Knox, Tessa Bellamy, additional, Mnzava, Abraham Peter, additional, Donnelly, Martin James, additional, and Fondjo, Etienne, additional

Published
2022
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35. The cytochrome P450 CYP325A is a major driver of pyrethroid resistance in the major malaria vector Anopheles funestus in Central Africa

Author

Wamba, Amelie N.R., Ibrahim, SulaimanSadi, Kusimo, Michael O, Muhammad, Abdullahi, Mugenzi, Leon M.J., Irving, Helen, Wondji, Murielle, Hearn, Jack, Bigoga, Jude, and Wondji, Charles

Subjects
qx_510, parasitic diseases, qx_600, qx_515, wc_750
Abstract

The overexpression and overactivity of key cytochrome P450s (CYP450) genes are major drivers of metabolic resistance to insecticides in African malaria vectors such as Anopheles funestus s.s. Previous RNAseq-based transcription analyses revealed elevated expression of CYP325A specific to Central African populations but its role in conferring resistance has not previously been demonstrated. In this study, RT-qPCR consistently confirmed that CYP325A is highly over-expressed in pyrethroid-resistant An. funestus from Cameroon, compared with a control strain and insecticide-unexposed mosquitoes. A synergist bioassay with PBO significantly recovered susceptibility for permethrin and deltamethrin indicating P450-based metabolic resistance. Analyses of the coding sequence of CYP325A Africa-wide detected high-levels of polymorphism, but with no predominant alleles selected by pyrethroid resistance. Geographical amino acid changes were detected notably in Cameroon. In silico homology modelling and molecular docking simulations predicted that CYP325A binds and metabolises type I and type II pyrethroids. Heterologous expression of recombinant CYP325A and metabolic assays confirmed that the most-common Cameroonian haplotype metabolises both type I and type II pyrethroids with depletion rate twice that the of the DR Congo haplotype. Analysis of the 1 kb putative promoter of CYP325A revealed reduced diversity in resistant mosquitoes compared to susceptible ones, suggesting a potential selective sweep in this region. The establishment of CYP325A as a pyrethroid resistance metabolising gene further explains pyrethroid resistance in Central African populations of An. funestus. Our work will facilitate future efforts to detect the causative resistance markers in the promoter region of CYP325A to design field applicable DNA-based diagnostic tools.

Published
2021

36. Diagnostic Accuracy of CareStart™ Malaria HRP2 and SD Bioline Pf/PAN for Malaria in Febrile Outpatients in Varying Malaria Transmission Settings in Cameroon

Author

Ali, Innocent Mbulli, primary, Nji, Akindeh Mbuh, additional, Bonkum, Jacob Chefor, additional, Moyeh, Marcel Nyuylam, additional, Carole, Guenang Kenfack, additional, Efon, Agni, additional, Dabou, Solange, additional, Tchuenkam, Valery Pacome Kom, additional, Tah, Calvino, additional, Kengne, Jean-Paul Chedjou, additional, Achu, Dorothy Fosah, additional, Bigoga, Jude Daiga, additional, and Mbacham, Wilfred Fon, additional

Published
2021
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37. Additional file 6 of Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Author

Niba, Peter Thelma Ngwa, Akindeh M. Nji, Marie-Solange Evehe, Ali, Innocent M., Netongo, Palmer Masumbe, Ngwafor, Randolph, Moyeh, Marcel N., Ngum, Lesley Ngum, Ndum, Oliva Ebie, Fon Abongwa Acho, Mbu’u, Cyrille Mbanwi, Fosah, Dorothy A., Atogho-Tiedeu, Barbara, Achonduh-Atijegbe, Olivia, Djokam-Dadjeu, Rosine, Chedjou, Jean Paul Kengne, Bigoga, Jude D., Moukoko, Carole Else Eboumbou, Ajua, Anthony, Achidi, Eric, Tallah, Esther, Leke, Rose G. F., Tourgordi, Alexis, Ringwald, Pascal, Alifrangis, Michael, and Mbacham, Wilfred F.

Abstract

Additional file 6. Assessment of publication bias using funnel plot and Egger’s regression test.

Published
2021
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38. Additional file 7 of Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

Author

Niba, Peter Thelma Ngwa, Akindeh M. Nji, Marie-Solange Evehe, Ali, Innocent M., Netongo, Palmer Masumbe, Ngwafor, Randolph, Moyeh, Marcel N., Ngum, Lesley Ngum, Ndum, Oliva Ebie, Fon Abongwa Acho, Mbu’u, Cyrille Mbanwi, Fosah, Dorothy A., Atogho-Tiedeu, Barbara, Achonduh-Atijegbe, Olivia, Djokam-Dadjeu, Rosine, Chedjou, Jean Paul Kengne, Bigoga, Jude D., Moukoko, Carole Else Eboumbou, Ajua, Anthony, Achidi, Eric, Tallah, Esther, Leke, Rose G. F., Tourgordi, Alexis, Ringwald, Pascal, Alifrangis, Michael, and Mbacham, Wilfred F.

Subjects
parasitic diseases
Abstract

Additional file 7. Haplotype analyses of anti-malarial drug resistance mutant allele frequencies reported in Cameroon.

Published
2021
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39. Additional file 1 of Community-based geographical distribution of Mycobacterium ulcerans VNTR-genotypes from the environment and humans in the Nyong valley, Cameroon

Author

Zeukeng, Francis, Ablordey, Anthony, Kakou-Ngazoa, Solange E., Ghogomu, Stephen Mbigha, Coulibaly, David N’golo, Nsoga, Marie Thérèse Ngo, Mbacham, Wilfred Fon, Bigoga, Jude Daiga, and Rousseau Djouaka

Abstract

Additional file 1. Distribution of sampled water bodies within the study sites in Akonolinga health district.

Published
2021
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40. Additional file 2 of Community-based geographical distribution of Mycobacterium ulcerans VNTR-genotypes from the environment and humans in the Nyong valley, Cameroon

Author

Zeukeng, Francis, Ablordey, Anthony, Kakou-Ngazoa, Solange E., Ghogomu, Stephen Mbigha, Coulibaly, David N’golo, Nsoga, Marie Thérèse Ngo, Mbacham, Wilfred Fon, Bigoga, Jude Daiga, and Rousseau Djouaka

Abstract

Additional file 2. Distribution of MU-positivity per sampled locality and sample type.

Published
2021
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41. Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon:a systematic review and meta-analysis (1998-2020)

Author

Niba, Peter Thelma Ngwa, Nji, Akindeh M, Evehe, Marie-Solange, Ali, Innocent M, Netongo, Palmer Masumbe, Ngwafor, Randolph, Moyeh, Marcel N, Ngum, Lesley Ngum, Ndum, Oliva Ebie, Acho, Fon Abongwa, Mbu'u, Cyrille Mbanwi, Fosah, Dorothy A, Atogho-Tiedeu, Barbara, Achonduh-Atijegbe, Olivia, Djokam-Dadjeu, Rosine, Chedjou, Jean Paul Kengne, Bigoga, Jude D, Moukoko, Carole Else Eboumbou, Ajua, Anthony, Achidi, Eric, Tallah, Esther, Leke, Rose G F, Tourgordi, Alexis, Ringwald, Pascal, Alifrangis, Michael, Mbacham, Wilfred F, Niba, Peter Thelma Ngwa, Nji, Akindeh M, Evehe, Marie-Solange, Ali, Innocent M, Netongo, Palmer Masumbe, Ngwafor, Randolph, Moyeh, Marcel N, Ngum, Lesley Ngum, Ndum, Oliva Ebie, Acho, Fon Abongwa, Mbu'u, Cyrille Mbanwi, Fosah, Dorothy A, Atogho-Tiedeu, Barbara, Achonduh-Atijegbe, Olivia, Djokam-Dadjeu, Rosine, Chedjou, Jean Paul Kengne, Bigoga, Jude D, Moukoko, Carole Else Eboumbou, Ajua, Anthony, Achidi, Eric, Tallah, Esther, Leke, Rose G F, Tourgordi, Alexis, Ringwald, Pascal, Alifrangis, Michael, and Mbacham, Wilfred F

Abstract

BACKGROUND: Malaria remains highly endemic in Cameroon. The rapid emergence and spread of drug resistance was responsible for the change from monotherapies to artemisinin-based combinations. This systematic review and meta-analysis aimed to determine the prevalence and distribution of Plasmodium falciparum drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon from January 1998 to August 2020.METHODS: The PRISMA-P and PRISMA statements were adopted in the inclusion of studies on single nucleotide polymorphisms (SNPs) of P. falciparum anti-malarial drug resistance genes (Pfcrt, Pfmdr1, Pfdhfr, Pfdhps, Pfatp6, Pfcytb and Pfk13). The heterogeneity of the included studies was evaluated using the Cochran's Q and I2 statistics. The random effects model was used as standard in the determination of heterogeneity between studies.RESULTS: Out of the 902 records screened, 48 studies were included in this aggregated meta-analysis of molecular data. A total of 18,706 SNPs of the anti-malarial drug resistance genes were genotyped from 47,382 samples which yielded a pooled prevalence of 35.4% (95% CI 29.1-42.3%). Between 1998 and 2020, there was significant decline (P < 0.0001 for all) in key mutants including Pfcrt 76 T (79.9%-43.0%), Pfmdr1 86Y (82.7%-30.5%), Pfdhfr 51I (72.2%-66.9%), Pfdhfr 59R (76.5%-67.8%), Pfdhfr 108 N (80.8%-67.6%). The only exception was Pfdhps 437G which increased over time (30.4%-46.9%, P < 0.0001) and Pfdhps 540E that remained largely unchanged (0.0%-0.4%, P = 0.201). Exploring mutant haplotypes, the study observed a significant increase in the prevalence of Pfcrt CVIET mixed quintuple haplotype from 57.1% in 1998 to 57.9% in 2020 (P < 0.0001). In addition, within the same study period, there was no significant change in the triple Pfdhfr IRN mutant haplotype (66.2% to 67.3%, P = 0.427). The Pfk13 amino acid polymorphisms associated with artemisinin resistance were not detected.CONCLUSIONS

Published
2021

42. High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon: a cluster randomised study

Author

Antonio-Nkondjio, Christophe, primary, Doumbe-Belisse, Patricia, additional, Djamouko-Djonkam, Landre, additional, Ngadjeu, Carmene Sandra, additional, Talipouo, Abdou, additional, Kopya, Edmond, additional, Bamou, Roland, additional, Mayi, Marie Paul Audrey, additional, Sonhafouo-Chiana, Nadege, additional, Nkahe, Diane Leslie, additional, Tabue, Raymond, additional, Fosah, Dorothy Achu, additional, Bigoga, Jude D, additional, Awono-Ambene, Parfait, additional, and Wondji, Charles S., additional

Published
2021
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45. Allelic Frequencies of Mutants of the Plasmodium Falciparum, Quinoline and Folate Metabolizing Genes in the West Region of Cameroon

Author

Ali, Innocent Mbulli, primary, Tchuenkam, Pacome Valery Kom, additional, Tagomo, Sandra Sob, additional, Mawamba, Hornela, additional, Moyeh, Marcel Nyuylam, additional, Nfor, Emmanuel Nfor, additional, Nji, Akindeh Mbuh, additional, Fomboh, Calvino Tah, additional, Nana, William Dorian, additional, Kengne, Jean-Paul Chedjou, additional, Neba, Peter Thelma Ngwa, additional, Ekoyol, Germaine Ekobo, additional, Achu, Dorothy Fosah, additional, Bigoga, Jude Daiga, additional, and Mbacham, Wilfred Fon, additional

Published
2021
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46. Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis protocol

Author

Niba, Peter Thelma Ngwa, primary, Nji, Akindeh M., additional, Evehe, Marie-Solange, additional, Ali, Innocent M., additional, Netongo, Palmer Masumbe, additional, Ngwafor, Randolph, additional, Moyeh, Marcel N., additional, Ngum, Lesley Ngum, additional, Ndum, Oliva Ebie, additional, Acho, Fon Abongwa, additional, Mbu'u, Cyrille Mbanwi, additional, Fosah, Dorothy A., additional, Atogho-Tiedeu, Barbara, additional, Achonduh-Atijegbe, Olivia, additional, Djokam-Dadjeu, Rosine, additional, Chedjou, Jean Paul Kengne, additional, Bigoga, Jude D., additional, Moukoko, Carole Else Eboumbou, additional, Ajua, Anthony, additional, Achidi, Eric, additional, Tallah, Esther, additional, Leke, Rose G. F., additional, Tourgordi, Alexis, additional, Ringwald, Pascal, additional, Alifrangis, Michael, additional, and Mbacham, Wilfred F., additional

Published
2020
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49. Clinical Efficacy and Safety of Artemisinin-based Combination Therapies in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Cameroon: A Systematic Review and Meta-Analysis from Individual Patient Data (2004-2020)

Author

Nji, Akindeh M., primary, Niba, Peter Thelma Ngwa, additional, Netongo, Palmer Masumbe, additional, Ali, Innocent M., additional, Ngwafor, Randolph, additional, Moyeh, Marcel N., additional, Mbu'u, Cyrille Mbanwi, additional, Fosah, Dorothy A., additional, Atogho-Tiedeu, Barbara, additional, Evehe, Marie-Solange, additional, Dadjeu, Rosine, additional, Chedjou, Jean Paul Kengne, additional, Bigoga, Jude D., additional, Ajua, Anthony, additional, Achidi, Eric, additional, Tallah, Esther, additional, Leke, Rose G. F., additional, Tourgordi, Alexis, additional, Ringwald, Pascal, additional, and Mbacham, Wilfred F., additional

Published
2020
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50. The effect of improved housing on indoor mosquito density and exposure to malaria in the rural community of Minkoameyos, Centre Region of Cameroon.

Author

Nguela, Rachel Laure, primary, Bigoga, Jude D., additional, Armel, Tedjou N., additional, Esther, Tallah Tayie Ngobiyo, additional, Dongmo, Line Lekou, additional, Boris, Njeambosay A., additional, Frederic, Tchouine, additional, Kazi, Riksum, additional, Williams, Peter, additional, Mbacham, Wilfred F., additional, and Leke, Rose G. F., additional

Published
2020
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