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7. Increased microchimerism in peripheral blood of women with systemic lupus erythematosus: relation with pregnancy

Author

Bos, E.M., Rijnink, E.C., Zandbergen, M., Pool, J.D.N. Diaz de, Almekinders, M.M., Berden, J.H., Bijl, M. de, Hagen, E.C., Kolster-Bijdevaate, C., Steup-Beekman, G.M., Wolterbeek, R.., Bloemenkamp, K.W.M., Baelde, H.J., Bruijn, J.A., Bajema, I.M., Wilhelmus, S., Bos, E.M., Rijnink, E.C., Zandbergen, M., Pool, J.D.N. Diaz de, Almekinders, M.M., Berden, J.H., Bijl, M. de, Hagen, E.C., Kolster-Bijdevaate, C., Steup-Beekman, G.M., Wolterbeek, R.., Bloemenkamp, K.W.M., Baelde, H.J., Bruijn, J.A., Bajema, I.M., and Wilhelmus, S.

Abstract

Item does not contain fulltext, OBJECTIVES: We aimed to determine the presence, amount and origin of microchimerism in peripheral blood of pregnant and non-pregnant parous women with systemic lupus erythematosus (SLE) as compared to control subjects. METHODS: We performed a comparative study in which peripheral blood was drawn from eleven female non-pregnant SLE-patients and 22 control subjects, and from six pregnant SLE-patients and eleven control subjects during gestation and up to six months postpartum. Quantitative PCR for insertion-deletion polymorphisms and null alleles was used to detect microchimerism in peripheral blood mononuclear cells and granulocytes. RESULTS: Microchimerism was detected more often in non-pregnant SLE-patients than control subjects (54.4% vs. 13.6%, respectively; p=0.03). When present, the median total number of foetal chimeric cells was 5 gEq/106 in patients and 2.5gEq/106 in control subjects (p=0.048). Microchimerism was mostly foetal in origin; maternal microchimerism was detected in one patient and one control subject. In control subjects, microchimerism was always derived from only one source whereas in 50% of patients it originated from multiple sources. The pregnant patients had a significantly higher median number of foetal chimeric cells in the granulocyte fraction just after delivery than control subjects (7.5 gEq/106 vs. 0 gEq/106, respectively; p=0.02). CONCLUSIONS: Just after delivery, SLE-patients had more microchimerism than control subjects. Three months post-partum, microchimerism was no longer detectable, only to reappear many years after the last pregnancy, more often and at higher levels in SLE-patients than in control subjects. This suggests that these chimeric cells may originate from non-circulating foetal chimeric stem cells.

Published
2022

8. Vaccination in adult patients with auto-immune inflammatory rheumatic diseases: A systematic literature review for the European League Against Rheumatism evidence-based recommendations for vaccination in adult patients with auto-immune inflammatory rheumatic diseases

Author

van Assen, S., Elkayam, O., Agmon-Levin, N., Cervera, R., Doran, M.F., Dougados, M., Emery, P., Geborek, P., Ioannidis, J.P.A., Jayne, D.R.W., Kallenberg, C.G.M., Müller-Ladner, U., Shoenfeld, Y., Stojanovich, L., Valesini, G., Wulffraat, N.M., and Bijl, M.

Published
2011
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11. Increased microchimerism in peripheral blood of women with systemic lupus erythematosus: relation with pregnancy

Author

Bos, E.M., Rijnink, E.C., Zandbergen, M., Pool, J.D.N. Diaz de, Almekinders, M.M., Berden, J.H., Bijl, M. de, Hagen, E.C., Kolster-Bijdevaate, C., Steup-Beekman, G.M., Wolterbeek, R.., Bloemenkamp, K.W.M., Baelde, H.J., Bruijn, J.A., Bajema, I.M., and Wilhelmus, S.

Subjects
Pregnancy Complications, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Rheumatology, Pregnancy, Immunology, Leukocytes, Mononuclear, Immunology and Allergy, Humans, Lupus Erythematosus, Systemic, Female, Real-Time Polymerase Chain Reaction, Chimerism
Abstract

Item does not contain fulltext OBJECTIVES: We aimed to determine the presence, amount and origin of microchimerism in peripheral blood of pregnant and non-pregnant parous women with systemic lupus erythematosus (SLE) as compared to control subjects. METHODS: We performed a comparative study in which peripheral blood was drawn from eleven female non-pregnant SLE-patients and 22 control subjects, and from six pregnant SLE-patients and eleven control subjects during gestation and up to six months postpartum. Quantitative PCR for insertion-deletion polymorphisms and null alleles was used to detect microchimerism in peripheral blood mononuclear cells and granulocytes. RESULTS: Microchimerism was detected more often in non-pregnant SLE-patients than control subjects (54.4% vs. 13.6%, respectively; p=0.03). When present, the median total number of foetal chimeric cells was 5 gEq/106 in patients and 2.5gEq/106 in control subjects (p=0.048). Microchimerism was mostly foetal in origin; maternal microchimerism was detected in one patient and one control subject. In control subjects, microchimerism was always derived from only one source whereas in 50% of patients it originated from multiple sources. The pregnant patients had a significantly higher median number of foetal chimeric cells in the granulocyte fraction just after delivery than control subjects (7.5 gEq/106 vs. 0 gEq/106, respectively; p=0.02). CONCLUSIONS: Just after delivery, SLE-patients had more microchimerism than control subjects. Three months post-partum, microchimerism was no longer detectable, only to reappear many years after the last pregnancy, more often and at higher levels in SLE-patients than in control subjects. This suggests that these chimeric cells may originate from non-circulating foetal chimeric stem cells.

Published
2021

12. Supplement to: Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis

Author

van Bon, L., Affandi, A. J., Broen, J., Christmann, R. B., Marijnissen, R. J., Stawski, L., Farina, G. A., Stifano, G., Mathes, A. L., Cossu, M., York, M., Collins, C., Wenink, M., Huijbens, R., Hesselstrand, R., Saxne, T., DiMarzio, M., Wuttge, D., Agarwal, S. K., Reveille, J. D., Assassi, S., Mayes, M., Deng, Y., Drenth, J. P.H., de Graaf, J., den Heijer, M., Kallenberg, C. G.M., Bijl, M., Loof, A., van den Berg, W. B., Joosten, L. A.B., Smith, V., de Keyser, F., Scorza, R., Lunardi, C., van Riel, P. L.C.M., Vonk, M., van Heerde, W., Meller, S., Homey, B., Beretta, L., Roest, M., Trojanowska, M., Lafyatis, R., and Radstake, T. R.D.J.

Published
2014

15. Opposed independent effects and epistasis in the complex association of IRF5 to SLE

Author

Ferreiro-Neira, I, Calaza, M, Alonso-Perez, E, Marchini, M, Scorza, R, Sebastiani, G D, Blanco, F J, Rego, I, Pullmann, Jr, R, Pullmann, R, Kallenberg, C G, Bijl, M, Skopouli, F N, Mavromati, M, Migliaresi, S, Barizzone, N, Ruzickova, S, Dostal, C, Schmidt, R E, Witte, T, Papasteriades, C, Kappou-Rigatou, I, Endreffy, E, Kovacs, A, Ordi-Ros, J, Balada, E, Carreira, P, Gomez-Reino, J J, and Gonzalez, A

Published
2007
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17. VISUALISATION OF THE ACTIVE CALCIFICATION PROCESS WITH 18-F SODIUM FLUORIDE PET/CT IN LIMITED CUTANEOUS SYSTEMIC SCLEROSIS WITH CALCINOSIS CUTIS IS FEASIBLE: A PILOT STUDY

Author

Atzeni, I. M., Hogervorst, E. M., Swart, G. M., De Leeuw, K., Bijl, M., Bos, R., Westra, J., Diercks, G., Van Goor, H., Bolling, M. C., Slart, R., Mulder, D. J., Groningen Institute for Organ Transplantation (GIOT), Translational Immunology Groningen (TRIGR), Groningen Kidney Center (GKC), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), and Cardiovascular Centre (CVC)

Published
2020

18. Diagnosing and treating antiphospholipid synarome: a consensus paper

Author

Limper, M., Leeuw, K. de, Lely, A.T., Westerink, J., Teng, Y.K.O., Eikenboom, J., Jansen, A.J.G., Molen, R.G. van der, Bijl, M., and Urbanus, R.T.

Subjects
All institutes and research themes of the Radboud University Medical Center, Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
Abstract

Item does not contain fulltext

Published
2019

25. SAT0285 VISUALISATION OF THE ACTIVE CALCIFICATION PROCESS WITH 18-F SODIUM FLUORIDE PET/CT IN LIMITED CUTANEOUS SYSTEMIC SCLEROSIS WITH CALCINOSIS CUTIS IS FEASIBLE: A PILOT STUDY

Author

Atzeni, I. M., primary, Hogervorst, E. M., additional, Swart, G. M., additional, De Leeuw, K., additional, Bijl, M., additional, Bos, R., additional, Westra, J., additional, Diercks, G., additional, Van Goor, H., additional, Bolling, M. C., additional, Slart, R., additional, and Mulder, D. J., additional

Published
2020
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41. Diagnosis and treatment of patients with antiphospholipid syndrome: A mixed-method evaluation of care in the netherlands

Author

Haneveld, M.J.K. (Mirthe J. Klein), Lemmen, C.H.C. (Caro H.C.), Brunekreef, T.E. (Tammo E.), Bijl, M. (Marc), Jansen, A.J.G. (Gerard), de Leeuw, K. (Karina), Spierings, J. (Julia), Limper, M., Haneveld, M.J.K. (Mirthe J. Klein), Lemmen, C.H.C. (Caro H.C.), Brunekreef, T.E. (Tammo E.), Bijl, M. (Marc), Jansen, A.J.G. (Gerard), de Leeuw, K. (Karina), Spierings, J. (Julia), and Limper, M.

Abstract

Objectives. The aims were to gain insight into the care provided to patients with APS in The Netherlands and to identify areas for improvement from the perspective of both patients and medical specialists. Methods. APS care was evaluated using qualitative and quantitative methods. Perspectives on APS care were explored using semi-structured interviews with medical specialists, patient focus groups and a cross-sectional, online patient survey. In order to assess current practice, medical records were reviewed retrospectively to collect data on clinical and laboratory manifestations and pharmacological treatment in six Dutch hospitals. Results. Fourteen medical specialists were interviewed, 14 patients participated in the focus groups and 79 patients completed the survey. Medical records of 237 patients were reviewed. Medical record review showed that only one-third of patients were diagnosed with APS within 3 months after entering specialist care. The diagnostic approach and management varied between centres and specialists. Almost 10% of all patients and 7% of triple-positive patients with thrombotic APS were not receiving any anticoagulant treatment at the time of medical record review. Correspondingly, poor recognition and fragmentation of care were reported as the main problems by medical specialists. Additionally, patients reported the lack of accessible, reliable patient education, psychosocial support and trust in physicians as important points for improvement. Conclusion. Delayed diagnosis, variability in management strategies and fragmentation of care were important limitations of APS care identified in this study. A remarkable 10% of patients did not receive any anticoagulant treatment.

Published
2020
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