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4. Evaluation of the Diagnostic Performance of American College of Rheumatology, EULAR, and National Institute for Health and Clinical Excellence Criteria Against Clinically Relevant Knee Osteoarthritis: Data From the CHECK Cohort

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Wang, Qiuke, Runhaar, Jos, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita M.A., MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Wang, Qiuke, Runhaar, Jos, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., and Bierma-Zeinstra, Sita M.A.

Published
2024

5. Two-year clinical follow-up enhances the diagnosis of early-stage hip osteoarthritis: data from check cohort

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Runhaar, Jos, Özbulut, Ömer, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita, CREDO expert group, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Runhaar, Jos, Özbulut, Ömer, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita, and CREDO expert group

Published
2024

6. Two-year clinical follow-up enhances the diagnosis of early-stage hip osteoarthritis:data from check cohort

Author

Runhaar, Jos, Özbulut, Ömer, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita, Runhaar, Jos, Özbulut, Ömer, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., and Bierma-Zeinstra, Sita

Abstract

OBJECTIVE: To provide a set of diagnostic criteria for early-stage hip osteoarthritis (OA) in primary care, using signs and symptoms monitored over 2 years in individuals with hip pain and/or stiffness. Additionally, the study aimed to see whether these factors were additive to factors based on baseline signs and symptoms only. METHODS: Data of the 543 persons with 735 symptomatic hips were collected from the prospective Cohort Hip and Cohort Knee cohort study. Using data from 5 to 10 years of follow-up, 24 experts (13 general practitioners, 11 secondary care physicians (6 rheumatologists and 5 orthopaedic surgeons)) inspected individuals' medical data on the presence of clinically relevant hip OA. Their diagnoses are used as reference standards. Backward selection method was used to provide models using the factors from baseline to 2 years of follow-up. Additionally, new models were combined with previously published models, using same selection method. Area under the curve (AUC) was calculated after each removal of factors in the final combined models. RESULTS: Radiographic factors and high-sensitive C reactive protein did not end up in any model with change factors only. AUC value (SD) of the final obtained model of change factors was 0.70 (0.01). Adding newly defined factors to previously published models significantly (p<0.0001) increased the AUC value to 0.75 (0.01). CONCLUSION: Final diagnostic criteria, consisting only of the factors obtained through history taking and physical examination, were able to detect early-stage hip OA associated with clinically relevant hip OA 5-10 years later, with 'moderate' precision.

Published
2024

7. Glucocorticoids

Author

Jacobs, Johannes W.G., primary, Goes, Marlies C. van der, additional, Bijlsma, Johannes W.J., additional, and da Silva, José A.P., additional

Published
2020
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9. Non-pharmacological interventions to promote work participation in people with rheumatic and musculoskeletal diseases: a systematic review and meta-analysis from the EULAR taskforce on healthy and sustainable work participation

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Butink, Maarten H.P., Webers, Casper, Verstappen, Suzanne M.M., Falzon, Louise, Betteridge, Neil, Wiek, Dieter, Woolf, Anthony D., Stamm, Tanja A., Burmester, Gerd R., Bijlsma, Johannes W.J., Christensen, Robin, Boonen, Annelies, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Butink, Maarten H.P., Webers, Casper, Verstappen, Suzanne M.M., Falzon, Louise, Betteridge, Neil, Wiek, Dieter, Woolf, Anthony D., Stamm, Tanja A., Burmester, Gerd R., Bijlsma, Johannes W.J., Christensen, Robin, and Boonen, Annelies

Published
2023

10. Consensus statement on blocking interleukin-6 receptor and interleukin-6 in inflammatory conditions: an update

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Aletaha, Daniel, Kerschbaumer, Andreas, Kastrati, Kastriot, Dejaco, Christian, Dougados, Maxime, McInnes, Iain B., Sattar, Naveed, Stamm, Tanja A., Takeuchi, Tsutomu, Trauner, Michael, Van Der Heijde, Désirée, Voshaar, Marieke, Winthrop, Kevin L., Ravelli, Angelo, Betteridge, Neil, Burmester, Gerd Rüdiger R., Bijlsma, Johannes W.J., Bykerk, Vivian, Caporali, Roberto, Choy, Ernest H., Codreanu, Catalin, Combe, Bernard, Crow, Mary K., De Wit, Maarten, Emery, Paul, Fleischmann, Roy M., Gabay, Cem, Hetland, Merete Lund, Hyrich, Kimme L., Iagnocco, Annamaria, Isaacs, John D., Kremer, Joel M., Mariette, Xavier, Merkel, Peter A., Mysler, Eduardo F., Nash, Peter, Nurmohamed, Michael T., Pavelka, Karel, Poor, Gyula, Rubbert-Roth, Andrea, Schulze-Koops, Hendrik, Strangfeld, Anja, Tanaka, Yoshiya, Smolen, Josef S., MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Aletaha, Daniel, Kerschbaumer, Andreas, Kastrati, Kastriot, Dejaco, Christian, Dougados, Maxime, McInnes, Iain B., Sattar, Naveed, Stamm, Tanja A., Takeuchi, Tsutomu, Trauner, Michael, Van Der Heijde, Désirée, Voshaar, Marieke, Winthrop, Kevin L., Ravelli, Angelo, Betteridge, Neil, Burmester, Gerd Rüdiger R., Bijlsma, Johannes W.J., Bykerk, Vivian, Caporali, Roberto, Choy, Ernest H., Codreanu, Catalin, Combe, Bernard, Crow, Mary K., De Wit, Maarten, Emery, Paul, Fleischmann, Roy M., Gabay, Cem, Hetland, Merete Lund, Hyrich, Kimme L., Iagnocco, Annamaria, Isaacs, John D., Kremer, Joel M., Mariette, Xavier, Merkel, Peter A., Mysler, Eduardo F., Nash, Peter, Nurmohamed, Michael T., Pavelka, Karel, Poor, Gyula, Rubbert-Roth, Andrea, Schulze-Koops, Hendrik, Strangfeld, Anja, Tanaka, Yoshiya, and Smolen, Josef S.

Published
2023

11. 2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases

Author

MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Fragoulis, George E., Nikiphorou, Elena, Dey, Mrinalini, Zhao, Sizheng Steven, Courvoisier, Delphine Sophie, Arnaud, Laurent, Atzeni, Fabiola, Behrens, Georg M.N., Bijlsma, Johannes W.J., Böhm, Peter, Constantinou, Costas A., Garcia-Diaz, Silvia, Kapetanovic, Meliha Crnkic, Lauper, Kim, Luís, Mariana, Morel, Jacques, Nagy, György, Polverino, Eva, Van Rompay, Jef, Sebastiani, Marco, Strangfeld, Anja, De Thurah, Annette, Galloway, James, Hyrich, Kimme L., MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Fragoulis, George E., Nikiphorou, Elena, Dey, Mrinalini, Zhao, Sizheng Steven, Courvoisier, Delphine Sophie, Arnaud, Laurent, Atzeni, Fabiola, Behrens, Georg M.N., Bijlsma, Johannes W.J., Böhm, Peter, Constantinou, Costas A., Garcia-Diaz, Silvia, Kapetanovic, Meliha Crnkic, Lauper, Kim, Luís, Mariana, Morel, Jacques, Nagy, György, Polverino, Eva, Van Rompay, Jef, Sebastiani, Marco, Strangfeld, Anja, De Thurah, Annette, Galloway, James, and Hyrich, Kimme L.

Published
2023

19. Contributors

Author

Abramson, Steven, primary, An, KaiNan, additional, Andrade, Felipe, additional, Ardoin, Stacy P., additional, Barton, Anne, additional, Baughman, Robert P., additional, Beaton, Dorcas E., additional, Beere, Helen M., additional, Beltran, Javier, additional, Bending, David, additional, Bennett, Robert M., additional, Bermas, Bonnie L., additional, Bertsias, George, additional, Bhardwaj, Nina, additional, Bijlsma, Johannes W.J., additional, Bockenstedt, Linda K., additional, Boers, Maarten, additional, Boilard, Eric, additional, Boin, Francesco, additional, Boumpas, Dimitrios T., additional, Boyle, David L., additional, Bradley, Sean, additional, Brown, Matthew, additional, Buch, Maya, additional, Buckley, Christopher D., additional, Budd, Ralph C., additional, Burg, Nathalie, additional, Burns, Christopher M., additional, Cannella, Amy C., additional, Carter, John D., additional, Chakravarty, Eliza F., additional, Chakravarty, Soumya D., additional, Chang, Christopher, additional, Cheng, Joseph S., additional, Chiodo, Christopher P., additional, Chung, Sharon, additional, Cleland, Leslie G., additional, Cohen, Stanley, additional, Colbert, Robert A., additional, Cook, Paul P., additional, Craft, Joseph E., additional, Crofford, Leslie J., additional, Cronstein, Bruce N., additional, Crow, Mary K., additional, Crowson, Cynthia S., additional, Culley, Kirsty L., additional, Cunnane, Gaye, additional, Dall'Era, Maria, additional, Darrah, Erika, additional, Davis, John M., additional, Bari, Cosimo De, additional, Dell'Accio, Francesco, additional, Diamond, Betty, additional, Di Cesare, Paul E., additional, Dixit, Rajiv, additional, Drenth, Joost P.H., additional, Dustin, Michael L., additional, El-Gabalawy, Hani S., additional, Elmamoun, Musaab, additional, Erickson, Alan R., additional, Erkan, Doruk, additional, Eyre, Stephen, additional, Fanouriakis, Antonis, additional, Felson, David T., additional, Field, Max, additional, Filer, Andrew, additional, Firestein, Gary S., additional, Fishman, Felicity G., additional, FitzGerald, Oliver, additional, Flaherty, John P., additional, Fors, César E., additional, Fortner, Karen A., additional, Gabriel, Sherine E., additional, Gasque, Philippe, additional, Gershwin, M. Eric, additional, Gladue, Heather S., additional, Goldring, Mary B., additional, Goldring, Steven R., additional, Golightly, Yvonne M., additional, Goodman, Stuart, additional, Gordon, Siamon, additional, Grassi, Walter, additional, Green, Douglas R., additional, Greenspan, Adam, additional, Gregersen, Peter, additional, Grimaldi, Christine, additional, Guilherme, Luiza, additional, Hajj-Ali, Rula A., additional, Haudenschild, Dominik R., additional, Hellmann, David B., additional, Holmdahl, Rikard, additional, Hsu, Joyce J., additional, Huddleston, James I., additional, Hudson, Alan P., additional, Huizinga, Thomas W.J., additional, Hunder, Gene G., additional, Iversen, Maura D., additional, Jacobs, Johannes W.G., additional, Jen, Ho, additional, Jordan, Joanne M., additional, Jorizzo, Joseph L., additional, Kalil, Jorge, additional, Kaufman, Kenton, additional, Kaufman, William S., additional, Kavanaugh, Arthur, additional, Keenan, Robert T., additional, Kenna, Tony, additional, Kerr, Darcy A., additional, Koch, Alisa E., additional, Kono, Dwight H., additional, Korsten, Peter, additional, Krakow, Deborah, additional, Krasnokutsky, Svetlana, additional, Lafeber, Floris P.J.G., additional, Lambert, Robert G.W., additional, Lane, Nancy E., additional, Langford, Carol A., additional, Laskin, Daniel M., additional, Layh-Schmitt, Gerlinde, additional, Lee, Lela A., additional, Lee, Tzielan C., additional, Lockshin, Michael D., additional, Lozada, Carlos J., additional, Lundberg, Ingrid E., additional, Luqmani, Raashid, additional, Luyten, Frank P., additional, Mader, Reuven, additional, Maksymowych, Walter, additional, Markenson, Joseph A., additional, Martin, Scott David, additional, Matteson, Eric L., additional, McGregor, Laura, additional, McInnes, Iain B., additional, McNamara, Elizabeth K., additional, Mikuls, Ted R., additional, Miller, Mark S., additional, Ming, Pedro Azevedo, additional, Moder, Kevin G., additional, Monach, Paul A., additional, Moulton, Vaishali R., additional, Nagaraju, Kanneboyina, additional, Nelson, Amanda E., additional, Nigrovic, Peter A., additional, Nistala, Kiran, additional, O'Dell, James R., additional, Okada, Yasunori, additional, Østergaard, Mikkel, additional, Otero, Miguel, additional, Palmer, Bradley M., additional, Panush, Richard S., additional, Peng, Stanford L., additional, Pillai, Shiv, additional, Pillinger, Michael H., additional, Plüddemann, Annette, additional, Polston, Gregory R., additional, Porcelli, Steven A., additional, Price, Mark D., additional, Reed, Ann M., additional, Reveille, John D., additional, Robinson, Angela B., additional, Robinson, Philip, additional, Robinson, William H., additional, Roosendaal, Goris, additional, Rosen, Antony, additional, Rosenbaum, James T., additional, Rosenberg, Andrew E., additional, Ruderman, Eric M., additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Sammaritano, Lisa R., additional, Samuels, Jonathan, additional, Sandborg, Christy I., additional, Sawalha, Amr H., additional, Saxena, Amit, additional, Schett, Georg, additional, Schutgens, Roger E.G., additional, Seldin, David C., additional, Shah, Binita, additional, Sikora, Keith A., additional, Simon, Anna, additional, Siraj, Dawd S., additional, Sorkin, Linda S., additional, St. Clair, E. William, additional, Stamp, Lisa K., additional, Stone, John H., additional, Suarez-Fueyo, Abel, additional, Svensson, Camilla I., additional, Sweiss, Nadera J., additional, Swigart, Carrie R., additional, Szekanecz, Zoltán, additional, Tait, Stephen, additional, Tanne, Antoine, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Theofilopoulos, Argyrios N., additional, Thornhill, Thomas S., additional, Torok, Kathryn S., additional, Toth, Michael J., additional, Tozman, Elaine C., additional, Trouw, Leendert A., additional, Tsokos, George C., additional, Tugwell, Peter, additional, Tutuncu, Zuhre, additional, Upadhyaya, Shivam, additional, Van, Annette H.M., additional, van der Linden, Sjef, additional, Van, Jos W.M., additional, Van, Jacob M., additional, Meter, Heather Van, additional, van Vollenhoven, Ronald F., additional, van Vulpen, Lize F.D., additional, Varga, John, additional, Vaseer, Samera, additional, Vasquez-Castellanos, Raul, additional, Veale, Douglas J., additional, Wakefield, Richard J., additional, Wallace, Mark S., additional, Wang, Ruoning, additional, Wang, Tingting, additional, Warshaw, David M., additional, Wedderburn, Lucy R., additional, Werth, Victoria P., additional, Wigley, Fredrick M., additional, Wofsy, David, additional, Wollheim, Frank A., additional, Wondimu, Elisabeth, additional, Wong, Cyrus, additional, Wortmann, Robert L., additional, Yelin, Edward, additional, Zayat, Ahmed, additional, Zou, Yong-Rui, additional, and Zurier, Robert B., additional

Published
2017
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24. Diagnosis for early stage knee osteoarthritis:probability stratification, internal and external validation; data from the CHECK and OAI cohorts

Author

Wang, Qiuke, Runhaar, Jos, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita M.A., Wang, Qiuke, Runhaar, Jos, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., and Bierma-Zeinstra, Sita M.A.

Abstract

Objective: To internally and externally validate our diagnostic criteria of early stage knee osteoarthritis (OA) in the CHECK and OAI cohorts. Design: We applied two previously developed diagnostic models to all knees in CHECK and OAI cohorts to calculate probabilities of early stage knee OA at baseline. Knees were categorized into three groups based on probability: ‘no OA’ (probability ≤ 30%), ‘uncertain’ (probability between 30% and 70%) and ‘early stage OA’ (probability ≥ 70%). To validate the diagnosis, we obtained OA related outcome measures at 10-year follow-up in the CHECK cohort, and at 8-9-year follow-up in the OAI cohort. We compared outcome measures between ‘no OA’ and ‘early stage OA’ knees, and between ‘no OA’ and ‘uncertain’ knees using generalized estimating equations. Results: In CHECK (n = 1042 knees) both models showed ‘early stage OA’ knees presented with significant and clinically relevant higher WOMAC scores, higher Kellgren & Lawrence (KL) grade, and higher rates of joint space narrowing (JSN) progression after 10 years, compared to ‘no OA’ knees. In OAI (n = 2937 knees) both models showed ‘early stage OA’ knees presented with significant and clinically relevant higher WOMAC scores, higher KL grade, and higher rates of KL and JSN progression after 8-9 years, compared to ‘no OA’ knees. Smaller, but still significant differences between ‘uncertain’ and ‘no OA’ knees were observed in both cohorts. Conclusions: These results support internal and external validity of the two sets of diagnostic criteria for early stage knee OA.

Published
2022

26. Glucocorticoids

Author

Spies, Cornelia M., Strehl, Cindy, van der Goes, Marlies C., Bijlsma, Johannes W.J., and Buttgereit, Frank

Published
2011
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32. Diagnostic criteria for early hip osteoarthritis; first steps, based on the CHECK study

Author

Runhaar, J., Ozbulut, Omer, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita M.A., Janssen, Rob P.A., Runhaar, J., Ozbulut, Omer, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita M.A., and Janssen, Rob P.A.

Abstract

OBJECTIVES: Although there is a general focus on early diagnosis and treatment of hip osteoarthritis, there are no validated diagnostic criteria for early-stage hip OA. The current study aimed to take the first steps in developing diagnostic criteria for early-stage hip OA, using factors obtained through history taking, physical examination, radiography and blood testing at the first consultation in individuals presenting with hip pain, suspicious for hip OA, in primary care.METHODS: Data of the 543 individuals with 735 symptomatic hips at baseline who had any follow-up data available from the prospective CHECK cohort study were used. A group of 26 clinical experts (GPs, Rheumatologists and Orthopedic surgeons) evaluated standardized clinical assessment forms of all subjects on the presence of clinically relevant hip OA 5 to 10 years after baseline. Using the expert based diagnoses as reference standard, a backward selection method was used to create predictive models based on pre-defined baseline factors from history taking, physical examination, radiography and blood testing.RESULTS: Prevalence of clinically relevant hip OA during follow-up was 22%. Created models contained 4 to 8 baseline factors (mainly WOMAC pain items, painful/restricted movements, and radiographic features) and obtained area under the curve between 0.62 ± 0.002 and 0.71 ± 0.002.CONCLUSION: Based on clinical and radiographic features of hip OA obtained at first consultation at a GP for pain/stiffness of the hip, the prediction of clinically relevant hip OA within 5 to 10 years was 'poor' to 'fair'.

Published
2021

33. Diagnosis of early stage knee osteoarthritis based on early clinical course: data from the CHECK cohort

Author

Wang, Quike, Runhaar, Jos, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita M.A., Janssen, Rob P.A., Wang, Quike, Runhaar, Jos, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita M.A., and Janssen, Rob P.A.

Abstract

Background: Early diagnosis of knee osteoarthritis (OA) is important in managing this disease, but such an early diagnostic tool is still lacking in clinical practice. The purpose of this study was to develop diagnostic models for early stage knee OA based on the first 2-year clinical course after the patient's initial presentation in primary care and to identify whether these course factors had additive discriminative value over baseline factors. Methods: We extracted eligible patients' clinical and radiographic data from the CHECK cohort and formed the first 2-year course factors according to the factors' changes over the 2 years. Clinical expert consensus-based diagnosis, which was made via evaluating patients' 5- to 10-year follow-up data, was used as the outcome factor. Four models were developed: model 1, included clinical course factors only; model 2, included clinical and radiographic course factors; model 3, clinical baseline factors + clinical course factors; and model 4, clinical and radiographic baseline factors + clinical and radiographic course factors. All the models were built by a generalized estimating equation with a backward selection method. Area under the receiver operating characteristic curve (AUC) and its 95% confidence interval (CI) were calculated for assessing model discrimination. Delong's method compared AUCs. Results: Seven hundred sixty-one patients with 1185 symptomatic knees were included in this study. Thirty-seven percent knees were diagnosed as OA at follow-up. Model 1 contained 6 clinical course factors; model 2: 6 clinical and 3 radiographic course factors; model 3: 6 baseline clinical factors combined with 5 clinical course factors; and model 4: 4 clinical and 1 radiographic baseline factors combined with 5 clinical and 3 radiographic course factors. Model discriminations are as follows: model 1, AUC 0.70 (95% CI 0.67-0.74); model 2, 0.74 (95% CI 0.71-0.77); model 3, 0.77 (95% CI 0.74-0.80); and model 4, 0.80

Published
2021

34. 2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis

Author

Nikiphorou, Elena, Santos, Eduardo José Ferreira, Marques, Andrea, Böhm, Peter, Bijlsma, Johannes W.J., Daien, Claire Immediato, Esbensen, Bente Appel, Ferreira, Ricardo J.O., Fragoulis, George E., Holmes, Pat, McBain, Hayley, Metsios, George S., Moe, Rikke Helene, Stamm, Tanja A., De Thurah, Annettede, Zabalan, Condruta, Carmona, Loreto, Bosworth, Ailsa, Nikiphorou, Elena, Santos, Eduardo José Ferreira, Marques, Andrea, Böhm, Peter, Bijlsma, Johannes W.J., Daien, Claire Immediato, Esbensen, Bente Appel, Ferreira, Ricardo J.O., Fragoulis, George E., Holmes, Pat, McBain, Hayley, Metsios, George S., Moe, Rikke Helene, Stamm, Tanja A., De Thurah, Annettede, Zabalan, Condruta, Carmona, Loreto, and Bosworth, Ailsa

Abstract

Background: An important but often insufficient aspect of care in people with inflammatory arthritis (IA) is empowering patients to acquire a good understanding of their disease and building their ability to deal effectively with the practical, physical and psychological impacts of it. Self-management skills can be helpful in this regard. Objectives: To develop recommendations for the implementation of self-management strategies in IA. Methods: A multidisciplinary taskforce of 18 members from 11 European countries was convened. A systematic review and other supportive information (survey of healthcare professionals (HCPs) and patient organisations) were used to formulate the recommendations. Results: Three overarching principles and nine recommendations were formulated. These focused on empowering patients to become active partners of the team and to take a more proactive role. The importance of patient education and key self-management interventions such as problem solving, goal setting and cognitive behavioural therapy were highlighted. Role of patient organisations and HCPs in promoting and signposting patients to available resources has been highlighted through the promotion of physical activity, lifestyle advice, support with mental health aspects and ability to remain at work. Digital healthcare is essential in supporting and optimising self-management and the HCPs need to be aware of available resources to signpost patients. Conclusion: These recommendations support the inclusion of self-management advice and resources in the routine management of people with IA and aim to empower and support patients and encourage a more holistic, patient-centred approach to care which could result in improved patient experience of care and outcomes.

Published
2021

35. Diagnostic criteria for early hip osteoarthritis:first steps, based on the CHECK study

Author

Runhaar, Jos, Özbulut, Ömer, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita M.A., Runhaar, Jos, Özbulut, Ömer, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., and Bierma-Zeinstra, Sita M.A.

Abstract

OBJECTIVES: Although there is a general focus on early diagnosis and treatment of hip OA, there are no validated diagnostic criteria for early-stage hip OA. The current study aimed to take the first steps in developing diagnostic criteria for early-stage hip OA, using factors obtained through history taking, physical examination, radiography and blood testing at the first consultation in individuals presenting with hip pain, suspicious for hip OA, in primary care. METHODS: Data of the 543 individuals with 735 symptomatic hips at baseline who had any follow-up data available from the prospective CHECK cohort study were used. A group of 26 clinical experts [general practitioners (GPs), rheumatologists and orthopaedic surgeons] evaluated standardized clinical assessment forms of all subjects on the presence of clinically relevant hip OA 5-10 years after baseline. Using the expert-based diagnoses as reference standard, a backward selection method was used to create predictive models based on pre-defined baseline factors from history taking, physical examination, radiography and blood testing. RESULTS: Prevalence of clinically relevant hip OA during follow-up was 22%. Created models contained four to eight baseline factors (mainly WOMAC pain items, painful/restricted movements and radiographic features) and obtained area under the curve between 0.62 (0.002) and 0.71 (0.002). CONCLUSION: Based on clinical and radiographic features of hip OA obtained at first consultation at a GP for pain/stiffness of the hip, the prediction of clinically relevant hip OA within 5-10 years was 'poor' to 'fair'.

Published
2021

36. Diagnosis of early stage knee osteoarthritis based on early clinical course:data from the CHECK cohort

Author

Wang, Qiuke, Runhaar, Jos, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., Bierma-Zeinstra, Sita M.A., Wang, Qiuke, Runhaar, Jos, Kloppenburg, Margreet, Boers, Maarten, Bijlsma, Johannes W.J., and Bierma-Zeinstra, Sita M.A.

Abstract

Background: Early diagnosis of knee osteoarthritis (OA) is important in managing this disease, but such an early diagnostic tool is still lacking in clinical practice. The purpose of this study was to develop diagnostic models for early stage knee OA based on the first 2-year clinical course after the patient’s initial presentation in primary care and to identify whether these course factors had additive discriminative value over baseline factors. Methods: We extracted eligible patients’ clinical and radiographic data from the CHECK cohort and formed the first 2-year course factors according to the factors’ changes over the 2 years. Clinical expert consensus-based diagnosis, which was made via evaluating patients’ 5- to 10-year follow-up data, was used as the outcome factor. Four models were developed: model 1, included clinical course factors only; model 2, included clinical and radiographic course factors; model 3, clinical baseline factors + clinical course factors; and model 4, clinical and radiographic baseline factors + clinical and radiographic course factors. All the models were built by a generalized estimating equation with a backward selection method. Area under the receiver operating characteristic curve (AUC) and its 95% confidence interval (CI) were calculated for assessing model discrimination. Delong’s method compared AUCs. Results: Seven hundred sixty-one patients with 1185 symptomatic knees were included in this study. Thirty-seven percent knees were diagnosed as OA at follow-up. Model 1 contained 6 clinical course factors; model 2: 6 clinical and 3 radiographic course factors; model 3: 6 baseline clinical factors combined with 5 clinical course factors; and model 4: 4 clinical and 1 radiographic baseline factors combined with 5 clinical and 3 radiographic course factors. Model discriminations are as follows: model 1, AUC 0.70 (95% CI 0.67–0.74); model 2, 0.74 (95% CI 0.71–0.77); model 3, 0.77 (95% CI 0.74–0.80); and model 4, 0.80 (95% CI 0.77–0

Published
2021

37. Effect on costs and quality-adjusted life-years of treat-to-target treatment strategies initiating methotrexate, or tocilizumab, or their combination in early rheumatoid arthritis

Author

Infection & Immunity, Lab Reumatologie/Klinische Immunologie, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Verhoeven, Maxime M.A., Tekstra, Janneke, van Laar, Jacob M., Pethö-Schramm, Attila, Borm, Michelle E.A., Bijlsma, Johannes W.J., Jacobs, Johannes W.G., Lafeber, Floris P.J.G., Welsing, Paco M.J., Infection & Immunity, Lab Reumatologie/Klinische Immunologie, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Verhoeven, Maxime M.A., Tekstra, Janneke, van Laar, Jacob M., Pethö-Schramm, Attila, Borm, Michelle E.A., Bijlsma, Johannes W.J., Jacobs, Johannes W.G., Lafeber, Floris P.J.G., and Welsing, Paco M.J.

Published
2021

38. Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis

Author

de Nijs, Ron N.J., Jacobs, Johannes W.G., Lems, Willem F., Laan, Roland F.J., Algra, Ale, Huisman, Anne-Margriet, Buskers, Erik, de Laet, Chris E.D., Oostveen, Ans C.M., Geusens, Piet P.M.M., Bruyn, George A.W., Dijkmans, Ben A.C., and Bijlsma, Johannes W.J.

Subjects
Corticosteroids -- Dosage and administration, Corticosteroids -- Complications and side effects, Osteoporosis -- Drug therapy, Alfacalcidol -- Dosage and administration, Calcifediol -- Dosage and administration, Vitamin D -- Dosage and administration, Alendronate -- Dosage and administration
Abstract

The effects of alfacalcidol and alendronate in patients with a rheumatic disease who are receiving glucocorticods are investigated and compared. The results have shown that alendronate is more effective in the prevention of glucocorticoid-induced bone loss than alfacalcidol in patients with rheumatic diseases.

Published
2006

39. Glucocorticoids

Author

Buttgereit, Frank, primary, Seibel, Markus J.H., additional, and Bijlsma, Johannes W.J., additional

Published
2013
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41. Contributors

Author

Abramson, Steven B., primary, An, Kai-Nan, additional, Andrade, Felipe, additional, Atkinson, John P., additional, Baeten, Dominique, additional, Baughman, Robert P., additional, Beaton, Dorcas E., additional, Bennett, Robert, additional, Benseler, Susanne M., additional, Bertsias, George, additional, Bhardwaj, Nina, additional, Bijlsma, Johannes W.J., additional, Bockenstedt, Linda K., additional, Boers, Maarten, additional, Boin, Francesco, additional, Boumpas, Dimitrios T., additional, Bresnihan, Barry, additional, Brettler, Doreen B., additional, Buckley, Christopher D., additional, Budd, Ralph C., additional, Burns, Christopher M., additional, Cannella, Amy C., additional, Chakravarty, Eliza F., additional, Chang, Christopher, additional, Cheng, Joseph S., additional, Chiodo, Christopher P., additional, Cleland, Leslie G., additional, Clowse, Megan E., additional, Cook, Paul P., additional, Craft, Joseph E., additional, Crofford, Leslie J., additional, Cronstein, Bruce N., additional, Crow, Mary K., additional, Cunnane, Gaye, additional, Cush, John J., additional, Cutolo, Maurizio, additional, Dall'Era, Maria, additional, Dao, Kathryn H., additional, Darrah, Erika, additional, Davis, John M., additional, DeGroot, Jeroen, additional, Devin, Clint, additional, Diamond, Betty, additional, Díaz-González, Federico, additional, Di Cesare, Paul E., additional, Dixit, Rajiv, additional, Drenth, Joost P.H., additional, Dustin, Michael L., additional, El-Gabalawy, Hani S., additional, Elkon, Keith B., additional, Erkan, Doruk, additional, Fanouriakis, Antonios, additional, Field, Max, additional, Filer, Andrew, additional, Firestein, Gary S., additional, Fitzgerald, Oliver, additional, Flaherty, John P., additional, Flanagan, Adrienne M., additional, Fortner, Karen A., additional, Gabriel, Sherine E., additional, Gaston, J.S. Hill, additional, Gay, Steffen, additional, Gershwin, M. Eric, additional, Gibofsky, Allan, additional, Ginsberg, Mark H., additional, Goldring, Mary B., additional, Goldring, Steven R., additional, Golightly, Yvonne M., additional, Goodman, Stuart, additional, Gordon, Siamon, additional, Grassi, Walter, additional, Greenspan, Adam, additional, Gregersen, Peter K., additional, Grimaldi, Christine, additional, Hajj-Ali, Rula A., additional, Harper, Lorraine, additional, Harris, Edward D., additional, Haudenschild, Dominik R., additional, Hellmann, David B., additional, Holmdahl, Rikard, additional, Hsu, Joyce J., additional, Huddleston, James I., additional, Huizinga, Thomas W.J., additional, Hunder, Gene G., additional, Hung, Emily W., additional, Inman, Robert D., additional, Iversen, Maura Daly, additional, Jacobs, Johannes W.G., additional, Jordan, Joanne M., additional, Jorizzo, Joseph L., additional, Kaufman, Kenton R., additional, Kaufman, William S., additional, Kavanaugh, Arthur, additional, Keenan, Robert T., additional, Khan, Shaukat, additional, Koch, Alisa E., additional, Kono, Dwight H., additional, Krakow, Deborah, additional, Lambert, Robert G.W., additional, Landewé, Robert B.M., additional, Lane, Nancy E., additional, Langford, Carol A., additional, Laskin, Daniel M., additional, Laxer, Ronald M., additional, Lee, David M., additional, Lee, Lela A., additional, Lee, Tzielan Chang, additional, Lockshin, Michael D., additional, Lories, Rik, additional, Lozada, Carlos J., additional, Lundberg, Ingrid E., additional, Luqmani, Raashid, additional, Luyten, Frank P., additional, Mader, Reuven, additional, Maksymowych, Walter P., additional, Mandell, Brian, additional, Martin, Scott David, additional, Matteson, Eric L., additional, McGirt, Matthew J., additional, McInnes, Iain B., additional, McNamara, Elizabeth Kaufman, additional, Mikuls, Ted R., additional, Miller, Mark S., additional, Moder, Kevin G., additional, Nagaraju, Kanneboyina, additional, Naides, Stanley J., additional, Nelson, Amanda E., additional, Nigrovic, Peter A., additional, Nistala, Kiran, additional, Nowatzky, Johannes, additional, O'Dell, James R., additional, Okada, Yasunori, additional, Orduño, Nataly Manjarrez, additional, Ospelt, Caroline, additional, Østergaard, Mikkel, additional, Palmer, Bradley M., additional, Panush, Richard S., additional, Peng, Stanford L., additional, Pillinger, Michael H., additional, Polston, Gregory R., additional, Porcelli, Steven A., additional, Price, Mark D., additional, Rasker, Johannes J., additional, Reveille, John D., additional, Roberts, W. Neal, additional, Ronneberger, Monika, additional, Rosen, Antony, additional, Rosenbaum, James T., additional, Rosenberg, Andrew E., additional, Ruderman, Eric M., additional, Ruutu, Merja, additional, Salmon, Jane E., additional, Samuels, Jonathan, additional, Sandborg, Christy I., additional, Savage, Caroline O.S., additional, Saxena, Amit, additional, Scher, Jose U., additional, Schett, Georg, additional, Seldin, David C., additional, Simon, Anna, additional, Siraj, Dawd S., additional, Skinner, Martha, additional, St. Clair, E. William, additional, Stamp, Lisa K., additional, Stone, John H., additional, Straub, Rainer H., additional, Sweeney, Susan E., additional, Sweiss, Nadera J., additional, Swigart, Carrie R., additional, Symmons, Deborah, additional, Szekanecz, Zoltan, additional, Tak, Paul-Peter, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Theofilopoulos, Argyrios N., additional, Thomas, Ranjeny, additional, Thornhill, Thomas S., additional, Torralba, Karina D., additional, Toth, Michael J., additional, Tugwell, Peter, additional, Tutuncu, Zuhre, additional, Upchurch, Katherine S., additional, van der Heijde, Désirée M.F.M., additional, van der Helm-van Mil, Annette H.M., additional, van der Linden, Sjef M., additional, van der Meer, Jos W.M., additional, van Laar, Jacob M., additional, Varga, John, additional, Wallace, Mark S., additional, Warshaw, David M., additional, Wedderburn, Lucy R., additional, Werth, Victoria P., additional, Wigley, Fredrick M., additional, Wise, Christopher M., additional, Wofsy, David, additional, Wolfe, Frederick, additional, Wollheim, Frank A., additional, Wortmann, Robert L., additional, Yelin, Edward, additional, Yu, David, additional, Zabriskie, John B., additional, Zurier, Robert B., additional, and Zuurmond, Anne-Marie, additional

Published
2013
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42. List of contributors

Author

Abraham, Roshini Sarah, primary, Albanesi, Cristina, additional, Alevizos, Ilias, additional, Anguita, Juan, additional, Anstead, Gregory M., additional, Aranow, Cynthia, additional, Austin, Howard A., additional, Babu, Subash, additional, Ballow, Mark C., additional, Balow, James E., additional, Barnidge, David R., additional, Belmont, John W., additional, Belz, Gabrielle T., additional, Ben-Yehuda, Dina, additional, Berek, Claudia, additional, Beukelman, Timothy, additional, Bieber, Thomas, additional, Bijlsma, Johannes W.J., additional, Bleesing, Jack J.H., additional, Blutt, Sarah E., additional, Bohle, Barbara, additional, Borzova, Elena, additional, Boyaka, Prosper N., additional, Knut, Brockow, additional, Bustamante, Jacinta, additional, Buttgereit, Frank, additional, Byrne, Mary, additional, Calder, Virginia L., additional, Carneiro-Sampaio, Magda, additional, Carotta, Sebastian, additional, Casanova, Jean-Laurent, additional, Cavacini, Lisa A., additional, Chan, Edwin S.L., additional, Chinen, Javier, additional, Chitnis, Tanuja, additional, Cho, Monique, additional, Christopher-Stine, Lisa, additional, Cope, Andrew P., additional, Corry, David B., additional, Cottrell, Tricia, additional, Coutinho, Antonio, additional, Craveiro, Marco, additional, Cron, Randy Q., additional, Cuellar-Rodriguez, Jennifer, additional, Dalakas, Marinos C., additional, de Barros, Stephanie C., additional, Devlin, Blythe H., additional, Diamond, Betty, additional, Dispenzieri, Angela, additional, Du Clos, Terry W., additional, Dupuis-Boisson, Stéphanie, additional, Eagar, Todd N., additional, Edhegard, Kim D., additional, Eisenbarth, George S., additional, Elmets, Craig A., additional, Erkan, Doruk, additional, Feinberg, Mark B., additional, Fikrig, Erol, additional, Fleisher, Thomas A., additional, Fontenot, Andrew P., additional, Franco, Luis M., additional, Freeman, Alexandra F., additional, Frew, Anthony J., additional, Friedman, Thea, additional, Fujihashi, Kohtaro, additional, Gadina, Massimo, additional, Galli, Stephen J., additional, Gaspar, H. Bobby, additional, Gatt, Moshe E., additional, Gershwin, M. Eric, additional, Ghoreschi, Kamran, additional, Gillespie, Susan L., additional, Goronzy, Jörg J., additional, Grattan, Clive E.H., additional, Greenspan, Neil S., additional, Grunebaum, Eyal, additional, Haeberli, Gabrielle, additional, Hall, Russell P., additional, Hamilton, Robert G., additional, Harriman, Gregory R., additional, Hasni, Sarfaraz A., additional, Helbling, Arthur, additional, Hingorani, Melanie, additional, Holland, Steven M., additional, Hruz, Petr L., additional, Illei, Gabor, additional, Imboden, John B., additional, Izraeli, Shai, additional, Jaffe, Elaine S., additional, Jagobi, Caroline, additional, Jalkanen, Sirpa, additional, Jetanalin, Pim, additional, Jouanguy, Emmanuelle, additional, June, Carl H., additional, Kallies, Axel, additional, Kaufmann, Stefan H.E., additional, Kavanaugh, Arthur, additional, Khan, Sabiha, additional, Kheradmand, Farrah, additional, Khoury, Samia J., additional, Koretzky, Gary A., additional, Korngold, Robert, additional, Kovalszki, Anna, additional, Kuhns, Douglas B., additional, Kyle, Robert A., additional, Lanza, Ian R., additional, Laurence, Arian, additional, Lee, Susan J., additional, Lenardo, Michael J., additional, Levinson, Arnold I., additional, Levy, Ofer, additional, Lewis, David B., additional, Lewis, Dorothy E., additional, Lightman, Sue L., additional, Lockshin, Michael D., additional, Lotze, Michael T., additional, Luong, Amber, additional, Mackay, Meggan, additional, Malo, Jean-Luc, additional, Maltzman, Jonathan S., additional, Mannon, Peter J., additional, Manns, Michael P., additional, Markert, Mary Louise, additional, McCarthy, Elizabeth A., additional, McDonald, Douglas R., additional, McGhee, Jerry R., additional, Melby, Peter C., additional, Metcalfe, Dean D., additional, Metz, Martin, additional, Miller, Stephen D., additional, Mitchell, Anna L., additional, Mittal, Shruti, additional, Miyara, Makoto, additional, Mold, Carolyn, additional, Moller, David R., additional, Mueller, Scott N., additional, Müller, Ulrich R., additional, Murphy, Philip M., additional, Noel, Pierre, additional, Notarangelo, Luigi, additional, Nutman, Thomas B., additional, Nutt, Stephen L., additional, Oliveira, João B., additional, Olson, Chris M., additional, O'Shea, John J., additional, Pai, Sung-Yun, additional, Pandit, Lavannya, additional, Paul, Mary E., additional, Pearce, Simon H.S., additional, Peterson, Erik J., additional, Picard, Capucine, additional, Pichler, Werner J., additional, Pittaluga, Stefania, additional, Puel, Anne, additional, Radbruch, Andreas, additional, Reece, Stephen T., additional, Reveille, John D., additional, Rich, Robert R., additional, Rivat, Christine, additional, Robinson, Bruce W.S., additional, Rodgers, John R., additional, Roifman, Chaim M., additional, Rosen, Antony, additional, Rosenbaum, James T., additional, Rouse, Barry T., additional, Rowley, Scott D., additional, Sakaguchi, Shimon, additional, Salmi, Marko, additional, Schroeder, Harry W., additional, Seibel, Markus J.H., additional, Selmi, Carlo, additional, Shafer, William M., additional, Shah, Prediman K., additional, Shankar, Sushma, additional, Shaw, Alan R., additional, Shearer, William T., additional, Sheikh, Javed, additional, Siegel, Richard, additional, Simon, Anna, additional, Simonian, Philip L., additional, Smith, Gideon P., additional, Smith, Justine R., additional, Snow, Andrew L., additional, Stephens, David S., additional, Stone, John H., additional, Straumann, Alex, additional, Su, Helen C., additional, Swainson, Louise, additional, Szymanska-Mroczek, Ewa, additional, Taylor, Naomi, additional, Thrasher, Adrian J., additional, Timares, Laura, additional, Torres, Raul M., additional, Uzel, Gülbŭ, additional, van der Meer, Jos W.M., additional, van der Hilst, Jeroen C.H., additional, Varga, John, additional, Waldman, Meryl, additional, Weiser, Peter, additional, Weller, Peter F., additional, Weyand, Cornelia M., additional, Whiteside, Theresa L., additional, Wigley, Fredrick M., additional, Winchester, Robert J., additional, Wing, Kajsa, additional, Wood, Kathryn, additional, Xu, Hui, additional, Zhang, Shen-Ying, additional, and Zimmermann, Valérie S., additional

Published
2013
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43. Gender differences in emotion regulation and relationships with perceived health in patients with rheumatoid arthritis

Author

van Middendorp, Henriet, Geenen, Rinie, Sorbi, Marjolijn J., Hox, Joop J., Vingerhoets, Ad J.J.M., van Doornen, Lorenz J.P., and Bijlsma, Johannes W.J.

Subjects
Rheumatoid arthritis -- Psychological aspects, Sex differences (Psychology) -- Research, Arthritics -- Psychological aspects, Arthritics -- Behavior, Health, Women's issues/gender studies
Abstract

Emotion regulation has been associated with perceived health in rheumatoid arthritis, which is diagnosed three times more often in women than men. Our aim was to examine gender differences in styles of emotion regulation (ambiguity, control, orientation, and expression) and gender-specificity of the associations between emotion regulation and perceived health (psychological well-being, social functioning, physical functioning, and disease activity) in 244 female and 91 male patients with rheumatoid arthritis. Women reported more emotional orientation than men, but did not differ from men with regard to ambiguity, control, and expression. Structural equation modelling showed that relationships between emotion regulation and perceived health were more frequent and stronger for women than men. This held especially for the affective dimension of health, while associations were similar for both women and men with regard to social and physical functioning. Only for women, the association between ambiguity and disease activity was significant, which appeared to be mediated by affective functioning. The observations that women are more emotionally oriented than men and that emotion regulation is more interwoven with psychological health in women than men, support the usefulness of a gender-sensitive approach in research and health care of patients with rheumatoid arthritis. KEYWORDS. Rheumatoid arthritis, gender differences, gender, emotion regulation, alexithymia, emotional disclosure

Published
2005

44. Pain coping and social support as predictors of long-term functional disability and pain in early rheumatoid arthritis

Author

Evers, Andrea W.M., Kraaimaat, Floris W., Geenen, Rinie, Jacobs, Johannes W.G., and Bijlsma, Johannes W.J.

Subjects
Chronic pain -- Psychological aspects, Chronic pain -- Research, Pain -- Care and treatment, Pain -- Research, Psychology and mental health
Abstract

Pain-related avoidance factors and social resources, as assessed by pain coping and social support, are supposed to have lasting effects on functional disability and pain in chronic pain disorders. As a follow-up to a prospective study demonstrating short-term effects after one year (Behaviour Research and Therapy, 36, 179-193, 1998), the role of pain coping and social support at the time of diagnosis was investigated in relationship to the long-term course of functional disability and pain after three and five years in 78 patients with rheumatoid arthritis (RA), taking into account personality characteristics of neuroticism and extraversion, clinical status and use of medication. In line with findings at the one-year follow-up, results showed that more passive pain coping predicted functional disability at the three-year, but not the five-year follow-up. In addition, low levels of social support at the time of diagnosis consistently predicted both functional disability and pain at the three and five-year follow-ups. Results indicate that pain coping and social support, assessed very early in the disease process, can affect long-term functional disability and pain in RA, and suggest that early interventions focusing on pain-related avoidance factors and social resources for patients at risk may beneficially influence long-term outcomes in RA. Keywords: Rheumatoid arthritis; Chronic pain; Functional disability; Pain coping; Social support; Avoidance

Published
2003

48. Contributors

Author

Aletaha, Daniel, primary, Alfredsson, Lars, additional, Backhaus, Marina, additional, Bathon, Joan M., additional, Bijlsma, Johannes W.J., additional, Boers, Maarten, additional, Breedveld, Ferdinand C., additional, Burmester, Gerd R., additional, Bushar, Nicholas D., additional, Buttgereit, Frank, additional, Conaghan, Philip G., additional, Dass, Shouvik, additional, Deane, Kevin D., additional, Dörner, Thomas, additional, Emery, Paul, additional, Esdaile, John M., additional, Farber, Donna L., additional, Freeston, Jane E., additional, Gay, Steffen, additional, Gerlag, Daniëlle M., additional, Goldring, Mary B., additional, Goycochea, Mavis, additional, van der Heijde, Désirée, additional, Hochberg, Marc C., additional, Holers, V. Michael, additional, Hueber, Axel J., additional, Huizinga, Tom W.J., additional, Johnsen, Alyssa K., additional, Kavanaugh, Arthur, additional, Keystone, Edward, additional, Kiener, Hans P., additional, Kinne, Raimund W., additional, Klareskog, Lars, additional, Kobelt, Gisela, additional, Koch, Alisa E., additional, Kremer, Joel, additional, Kvien, Tore K., additional, Lacaille, Diane, additional, Landewe, Robert, additional, Lee, David M., additional, Lipsky, Peter E., additional, Machold, Klaus P., additional, MacKenzie, C. Ronald, additional, Matteson, Eric L., additional, McInnes, Iain B., additional, Meyer, Christopher G., additional, Mima, Toru, additional, Mirjafari, Hoda, additional, Moreland, Larry W., additional, Moudgil, Kamal D., additional, Nigrovic, Peter A., additional, Nishimoto, Norihiro, additional, Okada, Sarah, additional, Okoye, Francesca I., additional, Oliver, Jacqueline E., additional, Ospelt, Caroline, additional, Paget, Stephen A., additional, Pai, Saparna, additional, Pap, Thomas, additional, Pappas, Dimitrios A., additional, Kaprove Penn, Sarah, additional, Plenge, Robert M., additional, Posalski, Jana, additional, Rajaiah, Rajesh, additional, Redlich, Kurt, additional, Rönnelid, Johan, additional, Scheinecker, Clemens, additional, Schett, Georg, additional, Scott, David L., additional, Siegel, Jeffrey N., additional, Silman, Alan J., additional, Simon, Lee S., additional, Singh, Jasvinder A., additional, Smolen, Josef S., additional, Solomon, Daniel H., additional, St. Clair, E. William, additional, Steiner, Günter, additional, Strand, Vibeke, additional, Stuhlmüller, Bruno, additional, Symmons, Deborah, additional, Szekanecz, Zoltán, additional, Tak, Paul Peter, additional, Taylor, Peter C., additional, Thomas, Ranjeny, additional, Turesson, Carl, additional, Vital, Edward M., additional, Ward, Michael M., additional, Weber, Deborah, additional, Weinblatt, Michael E., additional, Weisman, Michael H., additional, West, Sterling G., additional, Winthrop, Kevin L., additional, Zink, Angela, additional, and Zvaifler, Nathan J., additional

Published
2009
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