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Introduction: MicroRNAs (miRNAs) are small and non-coding RNA molecules which have multiple important regulatory roles within cells. With the deepening research on miRNAs, more and more researches show that the abnormal expression of miRNAs is closely related to various diseases. The relationship between miRNAs and diseases is crucial for discovering the pathogenesis of diseases and exploring new treatment methods. Methods: Therefore, we propose a new sparse autoencoder and MLP method (SPALP) to predict the association between miRNAs and diseases. In this study, we adopt advanced deep learning technologies, including sparse autoencoder and multi-layer perceptron (MLP), to improve the accuracy of predicting miRNAdisease associations. Firstly, the SPALP model uses a sparse autoencoder to perform feature learning and extract the initial features of miRNAs and diseases separately, obtaining the latent features of miRNAs and diseases. Then, the latent features combine miRNAs functional similarity data with diseases semantic similarity data to construct comprehensive miRNAs-diseases datasets. Subsequently, the MLP model can predict the unknown association among miRNAs and diseases. Result: To verify the performance of our model, we set up several comparative experiments. The experimental results show that, compared with traditional methods and other deep learning prediction methods, our method has significantly improved the accuracy of predicting miRNAs-disease associations, with 94.61% accuracy and 0.9859 AUC value. Finally, we conducted case study of SPALP model. We predicted the top 30 miRNAs that might be related to Lupus Erythematosus, Ecute Myeloid Leukemia, Cardiovascular, Stroke, Diabetes Mellitus five elderly diseases and validated that 27, 29, 29, 30, and 30 of the top 30 are indeed associated. Discussion: The SPALP approach introduced in this study is adept at forecasting the links between miRNAs and diseases, addressing the complexities of analyzing extensive bioinformatics datasets and enriching the comprehension contribution to disease progression of miRNAs. [ABSTRACT FROM AUTHOR]

In response to the growing number of diabetes cases worldwide, Our study addresses the escalating issue of diabetic eye disease (DED), a significant contributor to vision loss globally, through a pioneering approach. We propose a novel integration of a Genetic Grey Wolf Optimization (G-GWO) algorithm with a Fully Convolutional Encoder-Decoder Network (FCEDN), further enhanced by a Kernel Extreme Learning Machine (KELM) for refined image segmentation and disease classification. This innovative combination leverages the genetic algorithm and grey wolf optimization to boost the FCEDN's efficiency, enabling precise detection of DED stages and differentiation among disease types. Tested across diverse datasets, including IDRiD, DR-HAGIS, and ODIR, our model showcased superior performance, achieving classification accuracies between 98.5% to 98.8%, surpassing existing methods. This advancement sets a new standard in DED detection and offers significant potential for automating fundus image analysis, reducing reliance on manual examination, and improving patient care efficiency. Our findings are crucial to enhancing diagnostic accuracy and patient outcomes in DED management. [ABSTRACT FROM AUTHOR]

Introduction: DNA methylation is a critical epigenetic modification involving the addition of a methyl group to the DNA molecule, playing a key role in regulating gene expression without changing the DNA sequence. The main difficulty in identifying DNA methylation sites lies in the subtle and complex nature of methylation patterns, which may vary across different tissues, developmental stages, and environmental conditions. Traditional methods for methylation site identification, such as bisulfite sequencing, are typically labor-intensive, costly, and require large amounts of DNA, hindering high-throughput analysis. Moreover, these methods may not always provide the resolution needed to detect methylation at specific sites, especially in genomic regions that are rich in repetitive sequences or have low levels of methylation. Furthermore, current deep learning approaches generally lack sufficient accuracy. Methods: This study introduces the iDNA-OpenPrompt model, leveraging the novel OpenPrompt learning framework. The model combines a prompt template, prompt verbalizer, and Pre-trained Language Model (PLM) to construct the prompt-learning framework for DNA methylation sequences. Moreover, a DNA vocabulary library, BERT tokenizer, and specific label words are also introduced into the model to enable accurate identification of DNA methylation sites. Results and Discussion: An extensive analysis is conducted to evaluate the predictive, reliability, and consistency capabilities of the iDNA-OpenPrompt model. The experimental outcomes, covering 17 benchmark datasets that include various species and three DNA methylation modifications (4mC, 5hmC, 6mA), consistently indicate that our model surpasses outstanding performance and robustness approaches. [ABSTRACT FROM AUTHOR]

Artificial Intelligence (AI) is being increasingly used for diagnosing Vision-Threatening Diabetic Retinopathy (VTDR), which is a leading cause of visual impairment and blindness worldwide. However, previous automated VTDR detection methods have mainly relied on manual feature extraction and classification, leading to errors. This paper proposes a novel VTDR detection and classification model that combines different models through majority voting. Our proposed methodology involves preprocessing, data augmentation, feature extraction, and classification stages. We use a hybrid convolutional neural network-singular value decomposition (CNN-SVD) model for feature extraction and selection and an improved SVM-RBF with a Decision Tree (DT) and K-Nearest Neighbor (KNN) for classification. We tested ourmodel on the IDRiD dataset and achieved an accuracy of 98.06%, a sensitivity of 83.67%, and a specificity of 100% for DR detection and evaluation tests, respectively. Our proposed approach outperforms baseline techniques and provides a more robust and accurate method for VTDR detection. [ABSTRACT FROM AUTHOR]

The process of water photo-electrolysis possesses the capability to generate sustainable and renewable hydrogen fuels, consequently addressing the challenge of the irregularity of solar energy. Thus, developing highly-efficient and low-cost electrocatalysts for the use in contemporary renewable energy devices is critical. Herein, we report the fabrication of a novel BaCeFex−yBixO6 nanocrystalline material through a one-step solvothermal route using a post-annealing process at 500 °C. The synthesized material was investigated for its light-induced electrochemical HER and OER activities in alkaline media and the results revealed that the as-prepared BaCeFex−yBixO6-500 °C exhibited an excellent OER activity with an overpotential of 100 mV to achieve a current density of 10 mA cm−2, thus outperforming the IrO2 electrocatalyst. Besides its excellent water oxidation performance, the catalyst also demonstrated an admirable HER activity comparable to that of the Pt/C catalyst, indicating that the higher temperature treatment plays a significant role in achieving the maximum performance of the developed electrocatalyst. This work provides insights into the enhancement of light-induced OER and HER activities of bismuth oxides for a wide range of catalytic applications. [ABSTRACT FROM AUTHOR]

The advancement of single-cell sequencing technology has smoothed the ability to do biological studies at the cellular level. Nevertheless, single-cell RNA sequencing (scRNA-seq) data presents several obstacles due to the considerable heterogeneity, sparsity and complexity. Although many machine-learning models have been devised to tackle these difficulties, there is still a need to enhance their efficiency and accuracy. Current deep learning methods often fail to fully exploit the intrinsic interconnections within cells, resulting in unsatisfactory results. Given these obstacles, we propose a unique approach for analyzing scRNA-seq data called scMPN. This methodology integrates multi-layer perceptron and graph neural network, including attention network, to execute gene imputation and cell clustering tasks. In order to evaluate the gene imputation performance of scMPN, several metrics like cosine similarity, median L1 distance and root mean square error are used. These metrics are utilized to compare the efficacy of scMPN with other existing approaches. This research utilizes criteria such as adjusted mutual information, normalized mutual information and integrity score to assess the efficacy of cell clustering across different approaches. The superiority of scMPN over current single-cell data processing techniques in cell clustering and gene imputation investigations is shown by the experimental findings obtained from four datasets with gold-standard cell labels. This observation demonstrates the efficacy of our suggested methodology in using deep learning methodologies to enhance the interpretation of scRNA-seq data. [ABSTRACT FROM AUTHOR]

In the emerging field of image segmentation, Fully Convolutional Networks (FCNs) have recently become prominent. However, their effectiveness is intimately linked with the correct selection and fine-tuning of hyperparameters, which can often be a cumbersome manual task. The main aim of this study is to propose a more efficient, less labour-intensive approach to hyperparameter optimization in FCNs for segmenting fundus images. To this end, our research introduces a hyperparameter-optimized Fully Convolutional Encoder-Decoder Network (FCEDN). The optimization is handled by a novel Genetic Grey Wolf Optimization (G-GWO) algorithm. This algorithm employs the Genetic Algorithm (GA) to generate a diverse set of initial positions. It leverages Grey Wolf Optimization (GWO) to fine-tune these positions within the discrete search space. Testing on the Indian Diabetic Retinopathy Image Dataset (IDRiD), Diabetic Retinopathy, Hypertension, Age-related macular degeneration and Glacuoma ImageS (DR-HAGIS), and Ocular Disease Intelligent Recognition (ODIR) datasets showed that the G-GWO method outperformed four other variants of GWO, GA, and PSO-based hyperparameter optimization techniques. The proposed model achieved impressive segmentation results, with accuracy rates of 98.5% for IDRiD, 98.7% for DR-HAGIS, and 98.4%, 98.8%, and 98.5% for different sub-datasets within ODIR. These results suggest that the proposed hyperparameter-optimized FCEDN model, driven by the G-GWO algorithm, is more efficient than recent deep-learning models for image segmentation tasks. It thereby presents the potential for increased automation and accuracy in the segmentation of fundus images, mitigating the need for extensive manual hyperparameter adjustments. [ABSTRACT FROM AUTHOR]

Glaucoma is a progressive eye disease that can lead to blindness if left untreated. Early detection is crucial to prevent vision loss, but current manual scanning methods are expensive, time-consuming, and require specialized expertise. This study presents a novel approach to Glaucoma detection using the Enhanced Grey Wolf Optimized Support Vector Machine (EGWO-SVM) method. The proposed method involves preprocessing steps such as removing image noise using the adaptive median filter (AMF) and feature extraction using the previously processed speeded-up robust feature (SURF), histogram of oriented gradients (HOG), and Global features. The enhanced Grey Wolf Optimization (GWO) technique is then employed with SVM for classification. To evaluate the proposed method, we used the online retinal images for glaucoma analysis (ORIGA) database, and it achieved high accuracy, sensitivity, and specificity rates of 94%, 92%, and 92%, respectively. The results demonstrate that the proposed method outperforms other current algorithms in detecting the presence or absence of Glaucoma. This study provides a novel and effective approach to Glaucoma detection that can potentially improve the detection process and outcomes. [ABSTRACT FROM AUTHOR]

Vehicle detection based on very high-resolution (VHR) remote sensing images is beneficial in many fields such as military surveillance, traffic control, and social/economic studies. However, intricate details about the vehicle and the surrounding background provided by VHR images require sophisticated analysis based on massive data samples, though the number of reliable labeled training data is limited. In practice, data augmentation is often leveraged to solve this conflict. The traditional data augmentation strategy uses a combination of rotation, scaling, and flipping transformations, etc., and has limited capabilities in capturing the essence of feature distribution and proving data diversity. In this study, we propose a learning method named Vehicle Synthesis Generative Adversarial Networks (VS-GANs) to generate annotated vehicles from remote sensing images. The proposed framework has one generator and two discriminators, which try to synthesize realistic vehicles and learn the background context simultaneously. The method can quickly generate high-quality annotated vehicle data samples and greatly helps in the training of vehicle detectors. Experimental results show that the proposed framework can synthesize vehicles and their background images with variations and different levels of details. Compared with traditional data augmentation methods, the proposed method significantly improves the generalization capability of vehicle detectors. Finally, the contribution of VS-GANs to vehicle detection in VHR remote sensing images was proved in experiments conducted on UCAS-AOD and NWPU VHR-10 datasets using up-to-date target detection frameworks.