48 results on '"Billi, J."'
Search Results
2. SENSING OF SODIUM CHLORIDE AND GLUCOSE MIXED AQUEOUS SOLUTION BY USING A THERMOELASTIC OPTICAL INDICATOR MICROSCOPE
- Author
-
Billi J. Minasyan
- Subjects
General Medicine - Abstract
In the article we observed the microwave absorption of sodium chloride (NaCl) and glucose aqueous solution with different concentrations by using a thermoelastic optical indicator microscope (TEOIM). The non-invasive sensing technology of TEOIM is giving a big advantage compared to other detection technologies. By a TEOIM were visualized the change in distribution of microwave field depending on concentration of NaCl and glucose in $8-14~GHz$ range. This article is shown the investigation results for different concentrations of NaCl $(0-2.5\%)$ and represented the behavior of averaged microwave near-field intensity for glucose (varied of $0-10\%$ range) and NaCl (fixed at $0.9\%$) complex aqueous solutions.
- Published
- 2021
- Full Text
- View/download PDF
3. SENSING OF SODIUM CHLORIDE AND GLUCOSE MIXED AQUEOUS SOLUTION BY USING A THERMOELASTIC OPTICAL INDICATOR MICROSCOPE
- Author
-
Minasyan, Billi J., primary
- Published
- 2021
- Full Text
- View/download PDF
4. Separation of Mill Scale from Flume Wastewater Using a Dynamic Separator Toward Zero Wastes in the Steel Hot-Rolling Process
- Author
-
Billi J. McDowell, Naiyang Ma, Joseph Blake Houser, Dale E. Heinz, and Marcelo W. Andrade
- Subjects
Mill scale ,Waste management ,0211 other engineering and technologies ,Metals and Alloys ,Separator (oil production) ,Waste oil ,02 engineering and technology ,010501 environmental sciences ,Environmental Science (miscellaneous) ,01 natural sciences ,Flume ,Wastewater ,Mechanics of Materials ,Environmental science ,Mill ,Effluent ,021102 mining & metallurgy ,0105 earth and related environmental sciences ,Total suspended solids - Abstract
Along with the production of hot-rolled steel, a large amount of mixture of mill scale, water, and oil is constantly generated. It is of great importance to thoroughly separate these components from one another to make them recyclable. In the current research work, an industrial trial was carried out at an ArcelorMittal hot-rolling mill for producing clean mill scale with negligible oil by separating the mill scale from flume wastewater using a dynamic separator. A slip stream of wastewater was continuously pumped from a roughing mill flume into a tangentially motivated dynamic separator. The mill scale particles settled to the bottom of the separator and continuously moved with the water into a classifier, where the mill scale was removed and dewatered. Results of the trial show that compared to the conventional practice of sedimentation and reclamation of the mill scale in the pits, using the new method, the mill scale is more than five times cleaner with negligible oil, and the effluent water is more than three times cleaner with much less total suspended solids. As a result, after separation with the new method, the mill scale and the wastewater are more recyclable. In addition, the new technology can also lead to recovery of more waste oil and significant reduction of oily mill scale sludge.
- Published
- 2018
- Full Text
- View/download PDF
5. Berichte über Kreislaufstillstände und kardiopulmonale Reanimationen: Anpassung und Vereinfachung der Utstein-Schemata für Reanimationsregister
- Author
-
Jacobs, I., Nadkarni, V., Bahr, J., Berg, R. A., Billi, J. E., Bossaert, L., Cassan, P., Coovadia, A., DeEste, K., Finn, J., Halperin, H., Handley, A., Herlitz, J., Hickey, R., Idris, A., Kloeck, W., Larkin, G. L., Mancini, M. E., Mason, P., Mears, G., Monsieurs, K., Montgomery, W., Morley, P., Nichol, G., Nolan, J., Okada, K., Perlman, J., Shuster, M., Steen, P. A., Sterz, F., Tibballs, J., Timerman, S., Truitt, T., and Zideman, D.
- Published
- 2005
- Full Text
- View/download PDF
6. ILCOR Scientific Knowledge Gaps and Clinical Research Priorities for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care A Consensus Statement
- Author
-
Kleinman, M., Perkins, G., Bhanji, F., Billi, J., Bray, J., Callaway, C., de Caen, A., Finn, Judith, Hazinski, M., Lim, S., Maconochie, I., Morley, P., Nadkarni, V., Neumar, R., Nikolaou, N., Nolan, J., Reis, A., Sierra, A., Singletary, E., Soar, J., Stanton, D., Travers, A., Welsford, M., Zideman, D., Kleinman, M., Perkins, G., Bhanji, F., Billi, J., Bray, J., Callaway, C., de Caen, A., Finn, Judith, Hazinski, M., Lim, S., Maconochie, I., Morley, P., Nadkarni, V., Neumar, R., Nikolaou, N., Nolan, J., Reis, A., Sierra, A., Singletary, E., Soar, J., Stanton, D., Travers, A., Welsford, M., and Zideman, D.
- Abstract
Despite significant advances in the field of resuscitation science, important knowledge gaps persist. Current guidelines for resuscitation are based on the International Liaison Committee on Resuscitation 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations, which includes treatment recommendations supported by the available evidence. The writing group developed this consensus statement with the goal of focusing future research by addressing the knowledge gaps identified during and after the 2015 International Liaison Committee on Resuscitation evidence evaluation process. Key publications since the 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations are referenced, along with known ongoing clinical trials that are likely to affect future guidelines.
- Published
- 2018
7. Separation of Mill Scale from Flume Wastewater Using a Dynamic Separator Toward Zero Wastes in the Steel Hot-Rolling Process
- Author
-
Ma, Naiyang, primary, McDowell, Billi J., additional, Houser, Joseph Blake, additional, Andrade, Marcelo W., additional, and Heinz, Dale E., additional
- Published
- 2018
- Full Text
- View/download PDF
8. Part 2: Evidence evaluation and management of conflicts of interest: 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations
- Author
-
Morley, P., Lang, E., Aickin, R., Billi, J., Eigel, B., Ferrer, J., Finn, Judith, Gent, L., Griffin, R., Hazinski, M., Maconochie, I., Montgomery, W., Morrison, L., Nadkarni, V., Nikolaou, N., Nolan, J., Perkins, G., Sayre, M., Travers, A., Wyllie, J., Zideman, D., Morley, P., Lang, E., Aickin, R., Billi, J., Eigel, B., Ferrer, J., Finn, Judith, Gent, L., Griffin, R., Hazinski, M., Maconochie, I., Montgomery, W., Morrison, L., Nadkarni, V., Nikolaou, N., Nolan, J., Perkins, G., Sayre, M., Travers, A., Wyllie, J., and Zideman, D.
- Abstract
Introduction The international resuscitation community, under the guidance of the International Liaison Committee on Resuscitation (ILCOR), has continued its process to identify and summarize the published resuscitation science in the documents known as the ILCOR Consensus on Science with Treatment Recommendations (CoSTR). The accompanying articles represent the culmination of many years work, where a total of 250 evidence reviewers from 39 countries completed 165 systematic reviews on resuscitation related questions.
- Published
- 2015
9. Part 1: Executive summary. 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations
- Author
-
Nolan, J., Hazinski, M., Aickin, R., Bhanji, F., Billi, J., Callaway, C., Castren, M., de Caen, A., Ferrer, J., Finn, Judith, Gent, L., Griffin, R., Iverson, S., Lang, E., Lim, S., Maconochie, I., Montgomery, W., Morley, P., Nadkarni, V., Neumar, R., Nikolaou, N., Perkins, G., Perlman, J., Singletary, E., Soar, J., Travers, A., Welsford, M., Wyllie, J., Zideman, D., Nolan, J., Hazinski, M., Aickin, R., Bhanji, F., Billi, J., Callaway, C., Castren, M., de Caen, A., Ferrer, J., Finn, Judith, Gent, L., Griffin, R., Iverson, S., Lang, E., Lim, S., Maconochie, I., Montgomery, W., Morley, P., Nadkarni, V., Neumar, R., Nikolaou, N., Perkins, G., Perlman, J., Singletary, E., Soar, J., Travers, A., Welsford, M., Wyllie, J., and Zideman, D.
- Published
- 2015
10. Part 1: Executive Summary 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations
- Author
-
Hazinski, M., Nolan, J., Aickin, R., Bhanji, F., Billi, J., Callaway, C., Castren, M., de Caen, A., Ferrer, J., Finn, Judith, Gent, L., Griffin, R., Iverson, S., Lang, E., Lim, S., Maconochie, I., Montgomery, W., Morley, P., Nadkarni, V., Neumar, R., Nikolaou, N., Perkins, G., Perlman, J., Singletary, E., Soar, J., Travers, A., Welsford, M., Wyllie, J., Zideman, D., Hazinski, M., Nolan, J., Aickin, R., Bhanji, F., Billi, J., Callaway, C., Castren, M., de Caen, A., Ferrer, J., Finn, Judith, Gent, L., Griffin, R., Iverson, S., Lang, E., Lim, S., Maconochie, I., Montgomery, W., Morley, P., Nadkarni, V., Neumar, R., Nikolaou, N., Perkins, G., Perlman, J., Singletary, E., Soar, J., Travers, A., Welsford, M., Wyllie, J., and Zideman, D.
- Published
- 2015
11. Part 8: Education, implementation, and teams. 2015 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations
- Author
-
Finn, J., Bhanji, F., Lockey, A., Monsieurs, K., Frengley, R., Iwami, T., Lang, E., Ma, M., Mancini, M., McNeil, M., Greif, R., Billi, J., Nadkarni, V., Bigham, B., Bray, Janet, Breckwoldt, J., Brooks, S., Cheng, A., Donoghue, A., Duff, J., Edelson, D., Fischer, H., Gilfoyle, E., Hsieh, M., Kloeck, D., Ko, P., Leary, M., Olasveengen, T., Rittenberger, J., Schultz, R., Stub, D., Triska, Z., Wolbrink, T., Yang, C., Yeung, J., Finn, J., Bhanji, F., Lockey, A., Monsieurs, K., Frengley, R., Iwami, T., Lang, E., Ma, M., Mancini, M., McNeil, M., Greif, R., Billi, J., Nadkarni, V., Bigham, B., Bray, Janet, Breckwoldt, J., Brooks, S., Cheng, A., Donoghue, A., Duff, J., Edelson, D., Fischer, H., Gilfoyle, E., Hsieh, M., Kloeck, D., Ko, P., Leary, M., Olasveengen, T., Rittenberger, J., Schultz, R., Stub, D., Triska, Z., Wolbrink, T., Yang, C., and Yeung, J.
- Published
- 2015
12. Selection in a preferred provider organization enrollment
- Author
-
Billi, J E, Wise, C G, Sher, S I, Duran-Arenas, L, and Shapiro, L
- Subjects
Adult ,Male ,Academic Medical Centers ,Health Services Needs and Demand ,Michigan ,Insurance Benefits ,Age Factors ,Infant, Newborn ,Length of Stay ,Insurance Selection Bias ,Health Benefit Plans, Employee ,Patient Admission ,Socioeconomic Factors ,Insurance, Health, Reimbursement ,Ambulatory Care ,Humans ,Female ,Health Services Research ,Preferred Provider Organizations ,Sex Distribution ,health care economics and organizations ,Research Article ,Forecasting ,Retrospective Studies - Abstract
OBJECTIVE. The study was conducted to determine whether favorable or adverse selection occurred in a preferred provider organization (PPO) enrollment. DATA SOURCES AND STUDY SETTING. Secondary data sources were used to conduct a retrospective study of the utilization of health services and the demographic characteristics of the population involved in the first open enrollment in a new university-based PPO. The PPO under study, sponsored by the University of Michigan (UM) Medical Center, was offered to all 43,005 UM employees, dependents, and retirees. STUDY DESIGN. We analyzed insurance company payments during the one-year period prior to the enrollment to compare the utilization patterns of those who enrolled in the PPO with those who did not. DATA COLLECTION. Prior health care utilization data were obtained from Blue Cross-Blue Shield of Michigan on the entire university population for one year prior to the start of the PPO. Demographic data were obtained from the personnel office of the university. PRINCIPAL FINDINGS. The PPO group had a younger median age than the non-PPO group; the sex distribution was roughly similar for the two groups. In the PPO group 57 percent of all contracts were family contracts compared with only 30 percent in the non-PPO group. The PPO group experienced 20.6 percent lower inpatient payments per member, and 9.4 percent lower outpatient payments per member in the year prior to the enrollment. These differences resulted in an overall 18.7 percent lower payment per member for the PPO group in the year prior to their enrollment. CONCLUSIONS. The results show, based on prior insurance payments, that this PPO received favorable selection during the open enrollment, a finding consistent with favorable selection found in early HMO enrollment.
- Published
- 1993
13. Supplement to the investigation of two-phase alfa + beta titanium alloys
- Author
-
Billi, J. and Mamuzić, Ilija
- Subjects
titanium alloys ,two – phase alfa + beta ,structures pressing ,forging - Abstract
The article presents a brief survey of two-phase titanium alloys and the reason for the presence of non-homogenous structures in after defemation by pressing and forging. On the basis of investigations two reasons were ascertained for the formation of localized deformation bands. The first reason is the occurence of cooler and relatively rigid zones of conical shape and second adn more frequent reason is the localized adiabatic heating.
- Published
- 1992
14. Financial impact of the Medicare Fee Schedule on a department of anesthesiology in an academic medical center
- Author
-
Billi, J E, primary, Wise, C G, additional, Middleton, S C, additional, Loney, S J, additional, and Tremper, K K, additional
- Published
- 1993
- Full Text
- View/download PDF
15. Financial impact of the Medicare Fee Schedule on a large multispecialty faculty practice in an academic medical center
- Author
-
Billi, J E, primary, Wise, C G, additional, Middleton, S C, additional, and Burkhardt, J H, additional
- Published
- 1993
- Full Text
- View/download PDF
16. The effects of a low-cost intervention program on hospital costs.
- Author
-
Billi, John, Duran-Arenas, Luis, Wise, Christopher, Bernard, Annette, McQuillan, Mark, Stross, Jeoffrey, Billi, J E, Duran-Arenas, L, Wise, C G, Bernard, A M, McQuillan, M, and Stross, J K
- Subjects
ECONOMIC impact ,MEDICARE ,HOSPITAL care ,ACADEMIC medical centers ,LENGTH of stay in hospitals ,COMPARATIVE studies ,COST control ,DIAGNOSIS related groups ,INTERNAL medicine ,RESEARCH methodology ,MEDICAL quality control ,MEDICAL cooperation ,RESEARCH ,PROSPECTIVE payment systems ,EVALUATION research ,ECONOMICS - Abstract
Objective: To assess the impact of a low-cost education and feedback intervention designed to change physicians' utilization behavior on general medicine services.Design: Prospective, nonequivalent control group study of 1,432 admissions on four general medicine services over 12 months. Two services were randomly selected to receive the intervention. The other two served as controls. Admissions alternated between control and intervention services each day. Results were casemix-adjusted using diagnosis-related groups (DRGs). Three internists blinded to patient study group assignment assessed quality of care using a structured implicit instrument.Setting: Four general medicine services at a university hospital.Interventions: A brief orientation, a pamphlet of cost strategies and common charges, detailed interim bills, and information about projected length of stay and usual hospital reimbursement for each patient.Patients/participants: Each service was staffed by a full-time internal medicine faculty member, one third-year and two first-year internal medicine houseofficers, three medical students, and a clinical pharmacist. Physicians were assigned to services for one-month periods by a physician unaware of the study design. To prevent crossover, houseofficers assigned to a service returned to the same service for all subsequent general medical inpatient assignments.Measurements and Main Results: Geometric mean length of stay was 0.44 days (7.8%) shorter for the intervention services than for the control services (p less than 0.01), and geometric mean charges were $341 (7.1%) less (p less than 0.01). Effects persisted despite using a more precise cost estimate or casemix adjustment. Intervention houseofficers demonstrated superior cost-related attitudes but no difference in knowledge of charges. Audits of quality of care detected no significant difference between groups.Conclusion: This low-intensity intervention reduced length of stay and charges, even under the cost-constrained context of the prospective payment system. [ABSTRACT FROM AUTHOR]- Published
- 1992
- Full Text
- View/download PDF
17. Measurement of severity of illness and the Medicare prospective payment system: state of the art and future directions.
- Author
-
McMahon, Laurence, Billi, John, McMahon, L F Jr, and Billi, J E
- Published
- 1988
- Full Text
- View/download PDF
18. The effects of a cost-education program on hospital charges.
- Author
-
Billi, John, Hejna, Gwen, Wolf, Fredric, Shapiro, Letitia, Stross, Jeoffrey, Billi, J E, Hejna, G F, Wolf, F M, Shapiro, L R, and Stross, J K
- Subjects
ACADEMIC medical centers ,LENGTH of stay in hospitals ,COMPARATIVE studies ,COST control ,ECONOMICS ,EMPLOYEE orientation ,INTERNSHIP programs ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,USER charges ,EVALUATION research - Abstract
An educational intervention designed to change physicians' use of inpatient services was implemented on two general medical services for a year. The intervention consisted of a brief orientation to cost containment issues, a pamphlet that outlined practical cost containment strategies and listed the charges for commonly ordered tests and services, and access to detailed interim patients' bills generated during the hospitalization. Two concurrent control services received no intervention. Over 1,600 admissions were evaluated. The geometric mean length of stay was 0.61 days shorter on intervention services compared with control (5.15 vs. 5.76 days, p less than 0.01). The geometric mean hospital charges were $388 less for intervention patients ($3,199 vs. $3,587, p less than 0.005). Neither patients' demographic characteristics nor case mix could explain the reductions. The authors conclude that a simple program utilizing information already in existence in most hospitals can result in a significant and meaningful reduction in length of stay and charges. [ABSTRACT FROM AUTHOR]
- Published
- 1987
- Full Text
- View/download PDF
19. Use of the competing-hypotheses heuristic to reduce ‘pseudodiagnosticity’.
- Author
-
Wolf, F M, Gruppen, L D, and Billi, J E
- Published
- 1988
- Full Text
- View/download PDF
20. Prior hospitalization experience of DRG outliers versus inliers.
- Author
-
MCMAHON JR., LAURENCE F., SHAPIRO, LETITIA R., WEISSFELD, LISA A., BILLI, JOHN E., McMahon, L F Jr, Shapiro, L R, Weissfeld, L A, and Billi, J E
- Published
- 1988
- Full Text
- View/download PDF
21. Use of the competing-hypotheses heuristic to reduce ‘pseudodiagnosticity’
- Author
-
Wolf, F M, primary, Gruppen, L D, additional, and Billi, J E, additional
- Published
- 1988
- Full Text
- View/download PDF
22. Evaluation of a minimal-contact smoking cessation intervention in an outpatient setting.
- Author
-
Janz, N K, primary, Becker, M H, additional, Kirscht, J P, additional, Eraker, S A, additional, Billi, J E, additional, and Woolliscroft, J O, additional
- Published
- 1987
- Full Text
- View/download PDF
23. Controlling Hypertension through Education and Coaching in Kidney Disease (CHECK-D): protocol of a cluster randomised controlled trial.
- Author
-
Wright Nunes JA, Resnicow K, Richardson C, Levine D, Kerr E, Saran R, Gillespie B, Bragg-Gresham J, Delacroix EL, Considine S, Fan A, Ellies T, Garcia-Guzman L, Grzyb K, Klinkman M, Rockwell P, Billi J, Martin C, Collier K, Parker-Featherstone E, Bryant N, Seitz M, Lukela J, Brinley FJ, and Fagerlin A
- Subjects
- Humans, Blood Pressure, Randomized Controlled Trials as Topic, Mentoring methods, Hypertension therapy, Renal Insufficiency, Chronic therapy
- Abstract
Introduction: Chronic kidney disease (CKD) affects 30 million Americans. Early management focused on blood pressure (BP) control decreases cardiovascular morbidity and mortality. Less than 40% of patients with CKD achieve recommended BP targets due to many barriers. These barriers include a lack of understanding of the implications of their diagnosis and how to optimise their health.This cluster randomised control trial hypothesises that the combination of early primary care CKD education, and motivational interviewing (MI)-based health coach support, will improve patient behaviours aligned with BP control by increasing patient knowledge, self-efficacy and motivation. The results will aid in sustainable interventions for future patient-centric education and coaching support to improve quality and outcomes in patients with CKD stages 3-5. Outcomes in patients with CKD stages 3-5 receiving the intervention will be compared with similar patients within a control group. Continuous quality improvement (CQI) and systems methodologies will be used to optimise resource neutrality and leverage existing technology to support implementation and future dissemination. The innovative approach of this research focuses on the importance of a multidisciplinary team, including off-site patient coaching, that can intervene early in the CKD care continuum by supporting patients with education and coaching., Methods and Analysis: We will test impact of BP control when clinician-delivered education is followed by 12 months of MI-based health coaching. We will compare outcomes in 350 patients with CKD stages 3-5 between intervention and control groups in primary care. CQI and systems methodologies will optimise education and coaching for future implementation and dissemination., Ethics and Dissemination: This study was approved by the University of Michigan Institutional Review Boards (IRBMED) HUM00136011, HUM00150672 and SITE00000092 and the results of the study will be published on ClinicalTrials.gov, in peer-reviewed journals, as well as conference abstracts, posters and presentations., Trial Registration Number: NCT04087798., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
- Full Text
- View/download PDF
24. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation.
- Author
-
Nolan JP, Morley PT, Vanden Hoek TL, Hickey RW, Kloeck WG, Billi J, Böttiger BW, Morley PT, Nolan JP, Okada K, Reyes C, Shuster M, Steen PA, Weil MH, Wenzel V, Hickey RW, Carli P, Vanden Hoek TL, and Atkins D
- Subjects
- Adult, Age Factors, Cardiopulmonary Resuscitation methods, Child, Heart Arrest complications, Humans, Hypothermia, Induced methods, Life Support Care methods, Multicenter Studies as Topic, Patient Selection, Randomized Controlled Trials as Topic statistics & numerical data, Time Factors, Unconsciousness complications, Ventricular Fibrillation complications, Ventricular Fibrillation therapy, Cardiopulmonary Resuscitation standards, Emergency Service, Hospital standards, Heart Arrest therapy, Hypothermia, Induced standards, Life Support Care standards
- Published
- 2003
- Full Text
- View/download PDF
25. Clinical practice guidelines: quality improvement tools versus legal norms.
- Author
-
Wise CG and Billi JE
- Subjects
- Humans, United States, Malpractice legislation & jurisprudence, Practice Guidelines as Topic, Total Quality Management legislation & jurisprudence
- Abstract
The role of clinical guidelines in malpractice litigation has been controversial. The primary purpose of guidelines as a quality improvement tool must be sustained, and applications of guidelines beyond this purpose must be done carefully, with full recognition of inherent limitations.
- Published
- 1996
26. Potential effects of managed care on specialty practice at a university medical center.
- Author
-
Billi JE, Wise CG, Bills EA, and Mitchell RL
- Subjects
- Academic Medical Centers statistics & numerical data, Faculty, Medical statistics & numerical data, Health Maintenance Organizations economics, Health Workforce, Hospital Bed Capacity, 500 and over, Humans, Income, Insurance, Hospitalization, Medicaid, Michigan, Models, Econometric, United States, Academic Medical Centers economics, Economics, Medical, Health Maintenance Organizations statistics & numerical data, Insurance, Health, Reimbursement statistics & numerical data, Specialization
- Abstract
Background: The growth of managed care presents a challenge to academic medical centers, because the demand for the services of specialists is likely to continue decreasing. We estimated the number of enrollees the University of Michigan Medical Center would need in its health maintenance organization (HMO) system in order to provide revenue equivalent to the total revenue it received for professional specialty care in 1992., Methods: Rates of utilization and payment were based on the medical center's experience with managed care in 1992 in its independent practice association HMO, in which 25,000 members had capitated coverage and received primary and all specialty care from university physicians, and 15,000 members received primary care and most specialty care from physicians outside the university. We assumed that persons not enrolled in Medicare were all enrolled in managed-care plans. Primary care activity was excluded from the calculations of expense, revenue, and numbers of faculty members., Results: If all specialty services were provided by the university to HMO members, all the 21 specialties examined except obstetrics and gynecology and emergency services would require an enrollment of more than 250,000 to support the 1992 level of professional revenue and maintain the number of faculty members. If university services were provided only for referrals from a loosely affiliated network of community physicians in the HMO system, all the 19 specialties examined except plastic surgery would require an HMO enrollment of more than 1 million. In a combined model in which all specialty services were provided to 100,000 HMO members and network referrals were provided to 500,000 members, substantial changes in faculty composition would be needed in all the departments studied., Conclusions: Because of the large number of HMO members required, unless other changes occur, it is unrealistic to expect that the University of Michigan Medical Center could create an HMO or network large enough to support the specialty practice of the current number of faculty members at the 1992 level of financing.
- Published
- 1995
- Full Text
- View/download PDF
27. A model for practice guideline adaptation and implementation: empowerment of the physician.
- Author
-
Wise CG and Billi JE
- Subjects
- Feedback, Hospitals, University organization & administration, Humans, Leadership, Michigan, Models, Organizational, Patient Care Team, Practice Patterns, Physicians', Hospitals, University standards, Medical Staff, Hospital, Physician's Role, Power, Psychological, Practice Guidelines as Topic standards
- Abstract
The Medical Center model of practice guideline adaptation and implementation uses local clinical leaders to evaluate nationally endorsed guidelines, adapt those guidelines for use in the local setting, work with support staff to develop and apply methods for guideline implementation, and assist the evaluation of clinical practice and outcomes data. The model described here combines the guideline dissemination techniques of clinical leadership, implementation, and data support and feedback. This model overcomes the failures of previous models by incorporating local physician involvement during every step of practice guideline selection, adaptation, implementation, and evaluation, and by supporting the physician leaders with quality data, resources to support guideline implementation, and outcomes assessment and feedback.
- Published
- 1995
- Full Text
- View/download PDF
28. Lisinopril therapy associated with acute pancreatitis.
- Author
-
Marinella MA and Billi JE
- Subjects
- Acute Disease, Humans, Male, Middle Aged, Lisinopril adverse effects, Pancreatitis chemically induced
- Published
- 1995
29. MSMS critiques medical appropriateness review system.
- Author
-
Billi JE
- Subjects
- Michigan, Health Services Misuse, Managed Care Programs standards, Utilization Review standards
- Published
- 1995
30. Comparison of adrenergic agonists for the treatment of ventricular fibrillation and pulseless electrical activity.
- Author
-
Bleske BE and Billi JE
- Subjects
- Adrenergic Agonists pharmacology, Humans, Pulse, Adrenergic Agonists therapeutic use, Ventricular Fibrillation drug therapy
- Abstract
The primary role of epinephrine for the treatment of ventricular fibrillation (VF) and pulseless electrical activity (PEA) is to increase blood flow to the myocardium and central nervous system and ultimately improve survival. However, despite the administration of epinephrine, survival following VF or PEA is low. In an attempt to improve outcome from VF and PEA, alternative adrenergic agonists (methoxamine, phenylephrine, norepinephrine) which have different pharmacological properties than epinephrine have been evaluated. In order to determine the role of alternative adrenergic agonists for the treatment of VF and PEA this paper will compare the pharmacological properties and pharmacodynamic effects of these drugs to epinephrine. Specifically, receptor physiology along with the effects of adrenergic agonists on coronary perfusion pressure, survival, myocardial oxygen demand, and cerebral blood flow will be discussed.
- Published
- 1994
- Full Text
- View/download PDF
31. MSMS task force identifies priorities with third party payers.
- Author
-
Duhamel PA, Adelman SH, Barry JL, Billi JE, Black RW, Bluhm GB, Gordon M, Kolins MD, Margulis RR, and Maynard GD
- Subjects
- Communication, Humans, Michigan, Contract Services legislation & jurisprudence, Interprofessional Relations, Managed Care Programs legislation & jurisprudence, Reimbursement Mechanisms legislation & jurisprudence, Societies, Medical
- Published
- 1994
32. The development and evaluation of new versions of the written examination for the American Heart Association Advanced Cardiac Life Support provider course.
- Author
-
Billi JE, Gruppen LD, Boxer GJ, Oh M, Donnelly MB, Schroeder P, Littrell KA, Grauer K, Cavallaro DL, and Thies W
- Subjects
- American Heart Association, Evaluation Studies as Topic, Humans, Reproducibility of Results, United States, Cardiopulmonary Resuscitation education, Education, Medical, Continuing, Educational Measurement methods, Emergency Medicine education, Life Support Care
- Abstract
Study Objective: To create new versions of the written, multiple-choice examination used in the American Heart Association (AHA) Advanced Cardiac Life Support course, evaluate their reliability and difficulty, and then design revised versions with improved reliability and of standardized difficulty., Design: Psychometric evaluation of new versions of the AHA Advanced Cardiac Life Support test and revisions., Setting: AHA Advanced Cardiac Life Support courses., Participants: Candidates for completion of AHA Advanced Cardiac Life Support provider courses in five states., Intervention: The course content was divided into 11 content areas that were weighted for importance and appropriateness for testing in a multiple-choice format. The weights were used to construct a blueprint for a 50-question, multiple-choice examination. Five versions of the examination were then constructed based on the content blueprint, drawing from new questions and expert revision of previously written questions. Reliability and difficulty were assessed using 915 administrations at five different sites nationwide. The initial test versions differed in their degree of difficulty, which was not explained by demographic factors. The results were used to revise three of the versions to improve reliability and equalize difficulty of the versions., Measurements and Main Results: The final five versions have estimated reliability ranging from Cronbach's alpha of .62 to .86. Mean scores ranged from 87.4% to 89.1%., Conclusion: After field testing and revision, five examinations with acceptable reliability and roughly equal difficulty were constructed. The new examinations test the participants' knowledge of important aspects of resuscitation science and practice based on a blueprint of the course content.
- Published
- 1994
- Full Text
- View/download PDF
33. The integrated inpatient management model's clinical management information system.
- Author
-
McMahon LF Jr, Eward AM, Bernard AM, Hayward RA, Billi JE, Rosevear JS, and Southwell D
- Subjects
- Ancillary Services, Hospital economics, Clinical Medicine economics, Clinical Medicine organization & administration, Diagnosis-Related Groups classification, Diagnosis-Related Groups economics, Hospital Charges, Hospital Costs, Hospitals, University economics, Hospitals, University organization & administration, Michigan, Utilization Review economics, Ancillary Services, Hospital statistics & numerical data, Cost Allocation methods, Database Management Systems, Hospital Information Systems organization & administration, Relative Value Scales
- Abstract
The rising cost of health care has increased the call for cost control. The pressing need to control cost, coupled with the increase in managed care and prospective payment, has placed new urgency on administrators and clinicians to work collaboratively in providing efficient and effective care. We have developed the Integrated Inpatient Management Model (IIMM) to assist in this collaborative effort. We describe the IIMM's clinical information system that provides decision support to both administrators and clinicians. This clinical information system is the information backbone for the development and monitoring of practice guidelines or critical pathways. An integrated information system of this type is essential if hospitals are to prosper during the next decade.
- Published
- 1994
34. Drug therapy during cardiac arrest in two hospitals.
- Author
-
Bleske BE, Wheatley WK, Townsend KA, Guzzardo ML, Billi JE, and Shea MJ
- Subjects
- Algorithms, Heart Arrest therapy, Hospital Bed Capacity, 100 to 299, Hospital Bed Capacity, 500 and over, Hospitals, University statistics & numerical data, Hospitals, Urban statistics & numerical data, Humans, Life Support Care standards, Patient Care Team, Retrospective Studies, United States, Utilization Review, Ventricular Fibrillation therapy, Cardiopulmonary Resuscitation standards, Drug Utilization Review, Heart Arrest drug therapy, Hospitals, University standards, Hospitals, Urban standards
- Abstract
The results of a study evaluating the appropriateness of drug and defibrillation therapy given during cardiac arrest at two hospitals are reported. A retrospective study was performed to evaluate and compare the appropriateness of therapy given during adult cardiac arrest at a large teaching hospital (hospital 1) and at a smaller nonteaching hospital (hospital 2) as measured by conformance to advanced cardiac life support (ACLS) guidelines and by less stringent alternative criteria based on published data and clinical judgment. Patients included in the study were older than 18 years and had experienced at least one of five types of cardiac arrest: ventricular fibrillation, asystole, ventricular tachycardia, electromechanical dissociation, or bradycardia. The type of drug administered, the drug dosage, and the timing of dosages were evaluated, as were the timing of defibrillation attempts and the energy used for such attempts. Treatment decisions were considered inappropriate if they did not conform to standard (ACLS) or alternative criteria. In hospital 1, there were 1137 assessable decisions recorded for 75 cardiac arrests; of these, 205 (18%) were inappropriate according to standard criteria, and 96 (8.4%) were inappropriate according to alternative criteria. In hospital 2, there were 827 assessable decisions recorded for 57 cardiac arrests; of these, 173 (21%) were inappropriate according to standard criteria, and 98 (11.2%) were inappropriate according to alternative criteria. Inappropriate therapy during cardiac arrest occurred with a similar frequency in a large teaching hospital and in a smaller, nonteaching hospital. The number of inappropriate treatments was smaller when more liberal standards of therapy were used.
- Published
- 1993
35. Selection in a preferred provider organization enrollment.
- Author
-
Billi JE, Wise CG, Sher SI, Duran-Arenas L, and Shapiro L
- Subjects
- Academic Medical Centers organization & administration, Adult, Age Factors, Ambulatory Care statistics & numerical data, Female, Forecasting, Health Benefit Plans, Employee economics, Health Services Needs and Demand, Health Services Research, Humans, Infant, Newborn, Insurance Benefits, Insurance, Health, Reimbursement economics, Insurance, Health, Reimbursement statistics & numerical data, Length of Stay statistics & numerical data, Male, Michigan, Patient Admission statistics & numerical data, Preferred Provider Organizations economics, Retrospective Studies, Sex Distribution, Socioeconomic Factors, Health Benefit Plans, Employee statistics & numerical data, Insurance Selection Bias, Preferred Provider Organizations statistics & numerical data
- Abstract
Objective: The study was conducted to determine whether favorable or adverse selection occurred in a preferred provider organization (PPO) enrollment., Data Sources and Study Setting: Secondary data sources were used to conduct a retrospective study of the utilization of health services and the demographic characteristics of the population involved in the first open enrollment in a new university-based PPO. The PPO under study, sponsored by the University of Michigan (UM) Medical Center, was offered to all 43,005 UM employees, dependents, and retirees., Study Design: We analyzed insurance company payments during the one-year period prior to the enrollment to compare the utilization patterns of those who enrolled in the PPO with those who did not., Data Collection: Prior health care utilization data were obtained from Blue Cross-Blue Shield of Michigan on the entire university population for one year prior to the start of the PPO. Demographic data were obtained from the personnel office of the university., Principal Findings: The PPO group had a younger median age than the non-PPO group; the sex distribution was roughly similar for the two groups. In the PPO group 57 percent of all contracts were family contracts compared with only 30 percent in the non-PPO group. The PPO group experienced 20.6 percent lower inpatient payments per member, and 9.4 percent lower outpatient payments per member in the year prior to the enrollment. These differences resulted in an overall 18.7 percent lower payment per member for the PPO group in the year prior to their enrollment., Conclusions: The results show, based on prior insurance payments, that this PPO received favorable selection during the open enrollment, a finding consistent with favorable selection found in early HMO enrollment.
- Published
- 1993
36. The educational direction of the ACLS training program.
- Author
-
Billi JE
- Subjects
- Certification, Guidelines as Topic, Humans, Cardiopulmonary Resuscitation education
- Published
- 1993
- Full Text
- View/download PDF
37. Education in adult basic life support training programs.
- Author
-
Flint LS Jr, Billi JE, Kelly K, Mandel L, Newell L, and Stapleton ER
- Subjects
- Adult, Attitude to Health, Evaluation Studies as Topic, Heart Arrest therapy, Humans, Motivation, Cardiopulmonary Resuscitation education
- Abstract
The Panel on Educational Issues in Adult Basic Life Support Training Programs reviewed the characteristics of adult learners, aspects of educational theory, issues concerning barriers to learning and performing CPR, and issues concerning testing and evaluation. The panel made the following recommendations: a comprehensive evaluation of the basic life support program with the goal of improving the program design and educational tools must be initiated; adult programs must be designed to motivate laypersons to become trained in CPR, as well as to target relatives and friends of high-risk individuals; and emotional and attitudinal issues, including the student's reluctance to act in an emergency, must be addressed. Programs must incorporate information on the willingness of an individual to perform CPR; CPR programs must be simplified and focus on critical success factors; flexible educational approaches in programs are encouraged; flexible programming that addresses the needs of the allied health professional is encouraged; formal testing should be eliminated for layperson programs; and formal testing for health care providers and instructors should be continued.
- Published
- 1993
- Full Text
- View/download PDF
38. Education in adult advanced cardiac life support training programs: changing the paradigm. Members of the Advanced Cardiac Life Support Education Panel.
- Author
-
Billi JE and Membrino GE
- Subjects
- Adult, Consensus Development Conferences as Topic, Evaluation Studies as Topic, Health Education methods, Humans, Surveys and Questionnaires, Cardiopulmonary Resuscitation education
- Abstract
To develop a consensus for change in the educational aspects of the Advanced Cardiac Life Support (ACLS) Training Program, the American Heart Association appointed panel members to engage in a consensus process. At a preconference meeting held in the fall of 1991, panel members received broad input from experts in adult education, experienced ACLS educators, and resuscitation scientists. The panel then developed a statement based on the preconference discussions and presented it at the National Conference on CPR and Emergency Cardiac Care held in February 1992. The conference's recommendations and the process that led to them are described in this paper. The key conclusions of the consensus process are as follows. The purpose of ACLS programs is the education of health professionals whose jobs include the management of patients in arrest or near-arrest. The goal of each ACLS course is to have each participant succeed in acquiring the skills and knowledge required for resuscitation. Aspects of the course which threaten failure or raise anxiety should be minimized or eliminated. ACLS course directors are strongly encouraged to design courses whose content and presentation are best suited to the training, experience, and needs of the course participants. Flexibility is strongly encouraged. Evaluation (testing) should be used primarily for its educational value, to help both learners and instructors identify areas needing improvement. The problem learner should be identified as early as possible and should receive intensive remediation to achieve the goal of every participant acquiring the targeted skills and knowledge. Because skill retention is variable, rescuers should practice skills frequently in regular refresher sessions. At a minimum, retraining every two years is strongly recommended.
- Published
- 1993
- Full Text
- View/download PDF
39. The effects of a low-cost intervention program on hospital costs.
- Author
-
Billi JE, Duran-Arenas L, Wise CG, Bernard AM, McQuillan M, and Stross JK
- Subjects
- Cost Control, Humans, Length of Stay economics, Michigan, Prospective Payment System economics, Quality of Health Care, United States, Diagnosis-Related Groups, Hospitalization economics, Hospitals, Teaching economics, Internal Medicine economics, Medicare economics, Prospective Payment System organization & administration
- Abstract
Objective: To assess the impact of a low-cost education and feedback intervention designed to change physicians' utilization behavior on general medicine services., Design: Prospective, nonequivalent control group study of 1,432 admissions on four general medicine services over 12 months. Two services were randomly selected to receive the intervention. The other two served as controls. Admissions alternated between control and intervention services each day. Results were casemix-adjusted using diagnosis-related groups (DRGs). Three internists blinded to patient study group assignment assessed quality of care using a structured implicit instrument., Setting: Four general medicine services at a university hospital., Interventions: A brief orientation, a pamphlet of cost strategies and common charges, detailed interim bills, and information about projected length of stay and usual hospital reimbursement for each patient., Patients/participants: Each service was staffed by a full-time internal medicine faculty member, one third-year and two first-year internal medicine houseofficers, three medical students, and a clinical pharmacist. Physicians were assigned to services for one-month periods by a physician unaware of the study design. To prevent crossover, houseofficers assigned to a service returned to the same service for all subsequent general medical inpatient assignments., Measurements and Main Results: Geometric mean length of stay was 0.44 days (7.8%) shorter for the intervention services than for the control services (p less than 0.01), and geometric mean charges were $341 (7.1%) less (p less than 0.01). Effects persisted despite using a more precise cost estimate or casemix adjustment. Intervention houseofficers demonstrated superior cost-related attitudes but no difference in knowledge of charges. Audits of quality of care detected no significant difference between groups., Conclusion: This low-intensity intervention reduced length of stay and charges, even under the cost-constrained context of the prospective payment system.
- Published
- 1992
- Full Text
- View/download PDF
40. Information gathering and integration as sources of error in diagnostic decision making.
- Author
-
Gruppen LD, Wolf FM, and Billi JE
- Subjects
- Bias, Choice Behavior, Evaluation Studies as Topic, Humans, Bayes Theorem, Data Collection standards, Data Interpretation, Statistical, Decision Support Techniques, Diagnostic Errors, Physicians psychology, Problem Solving
- Abstract
This research examined the relative importance of information gathering versus information utilization in accounting for errors in diagnostic decision making. Two experiments compared physicians' performances under two conditions: one in which they gathered a limited amount of diagnostic information and then integrated it before making a decision, and the other in which they were given all the diagnostic information and needed only to integrate it. The physicians: 1) frequently failed to select normatively optimal information in both experimental conditions; 2) were more confident about the correctness of their information selection when their task was limited to information integration than when it also included information gathering; and 3) made diagnoses in substantial agreement with those indicated by applying normative procedures to the same data. Physicians appear to have difficulties recognizing the diagnosticity of information, which often results in decisions that are pseudodiagnostic or based on diagnostically worthless information.
- Published
- 1991
- Full Text
- View/download PDF
41. Epidemic methanol poisoning: clinical and biochemical analysis of a recent episode.
- Author
-
Swartz RD, Millman RP, Billi JE, Bondar NP, Migdal SD, Simonian SK, Monforte JR, McDonald FD, Harness JK, and Cole KL
- Subjects
- Adult, Alcoholic Intoxication diagnosis, Alcoholic Intoxication epidemiology, Bicarbonates blood, Central Nervous System Diseases etiology, Erythrocyte Indices, Eye Diseases etiology, Humans, Male, Methanol blood, Michigan, Middle Aged, Triage, Disease Outbreaks epidemiology, Methanol poisoning, Prisons
- Published
- 1981
- Full Text
- View/download PDF
42. Rapidly progressive, fatal pulmonary fibrosis induced by carmustine.
- Author
-
Patten GA, Billi JE, and Rotman HH
- Subjects
- Astrocytoma drug therapy, Brain Neoplasms drug therapy, Female, Humans, Lung pathology, Middle Aged, Postoperative Care, Pulmonary Fibrosis pathology, Carmustine adverse effects, Pulmonary Fibrosis chemically induced
- Published
- 1980
43. Cardiopulmonary resuscitation: an update.
- Author
-
Billi JE and Stross JK
- Subjects
- Airway Obstruction therapy, American Heart Association, Bicarbonates therapeutic use, Bretylium Tosylate therapeutic use, Calcium therapeutic use, Catheterization, Electric Countershock, Esophagus, Humans, Intubation instrumentation, Respiration, Artificial methods, Sodium therapeutic use, Sodium Bicarbonate, United States, Heart Arrest therapy, Resuscitation education
- Abstract
We are currently witnessing the emergence of a physiologic approach to cardiopulmonary resuscitation. The algorithms and recommendations provided by the AHA provide an excellent framework for managing cardiac emergencies. As new knowledge becomes available, these recommendations should be modified and expanded. Continued assessment of the patient is a critical factor in managing cardiac arrest. As more complex technology and newer medications crowd the resuscitation scene, it is extremely important not to lose sight of the patient and the basics of good resuscitation: airway, breathing, and circulation. Technology provides helpful adjuncts to our assessment but cannot replace direct contact with the patient and the information gathered by direct observation. Students often fix their attention on the cardiac monitor, treating the electrical activity but ignoring the patient. Only by bringing together our observations from the patient, the laboratory, and our diagnostic tools will our knowledge of resuscitation develop to the point where we can improve survival from cardiac arrest.
- Published
- 1984
44. Measurement of severity of illness and the Medicare prospective payment system: state of the art and future directions.
- Author
-
McMahon LF Jr and Billi JE
- Subjects
- United States, Medicare, Prospective Payment System, Severity of Illness Index
- Published
- 1988
- Full Text
- View/download PDF
45. The effects of a cost-education program on hospital charges.
- Author
-
Billi JE, Hejna GF, Wolf FM, Shapiro LR, and Stross JK
- Subjects
- Cost Control methods, Hospitals, University economics, Length of Stay economics, Economics, Hospital, Fees and Charges, Inservice Training, Internship and Residency
- Abstract
An educational intervention designed to change physicians' use of inpatient services was implemented on two general medical services for a year. The intervention consisted of a brief orientation to cost containment issues, a pamphlet that outlined practical cost containment strategies and listed the charges for commonly ordered tests and services, and access to detailed interim patients' bills generated during the hospitalization. Two concurrent control services received no intervention. Over 1,600 admissions were evaluated. The geometric mean length of stay was 0.61 days shorter on intervention services compared with control (5.15 vs. 5.76 days, p less than 0.01). The geometric mean hospital charges were $388 less for intervention patients ($3,199 vs. $3,587, p less than 0.005). Neither patients' demographic characteristics nor case mix could explain the reductions. The authors conclude that a simple program utilizing information already in existence in most hospitals can result in a significant and meaningful reduction in length of stay and charges.
- Published
- 1987
- Full Text
- View/download PDF
46. Differential diagnosis and the competing-hypotheses heuristic. A practical approach to judgment under uncertainty and Bayesian probability.
- Author
-
Wolf FM, Gruppen LD, and Billi JE
- Subjects
- Bayes Theorem, Humans, Internship and Residency, Models, Theoretical, Problem Solving, Diagnosis, Differential
- Abstract
Evaluating the same diagnostic information across the plausible competing diagnoses is a practical strategy (ie, heuristic) to guide decision making in the face of uncertainty. The prevalence of use of this competing-hypotheses heuristic by 89 first-year house officers was examined in three simulated patient cases. Results indicated that only a minority (24%) of the house officers selected optimal diagnostic information consistent with this Bayesian heuristic across all three cases. Almost all (97%) of the house officers selecting optimal diagnostic information were able to identify the most probable diagnosis specified by Bayes' theorem, while only a chance number (53%) of house officers selecting nonoptimal information were able to identify the most probable diagnosis. The competing-hypotheses heuristic is discussed within the context of diagnostic problem-solving models derived from the literature on medical decision making and clinicopathological conference case records. It is suggested that the heuristic, which does not necessitate any mathematical calculations, may be useful as a complement to clinical judgment.
- Published
- 1985
47. Beliefs about control of smoking and smoking behavior: a comparison of different measures in different groups.
- Author
-
Kirscht JP, Janz NK, Becker MH, Eraker SA, Billi JE, and Woolliscroft JO
- Subjects
- Attitude, Female, Humans, Internal-External Control, Male, Tobacco Use Disorder therapy, Tobacco Use Disorder psychology
- Abstract
This study investigated several measures of beliefs about controlling smoking as predictors of cessation and reduction at one and six months after a medically-based control program. Smokers (n = 250 total) attending general medicine clinics at University and Veterans Administration facilities received advice to quit from both physicians and nurses. Beliefs about difficulty resisting urges to smoke in 15 situations, their frequency of occurrence, and general level of difficulty were assessed at baseline. For the University group of patients, significant relationships were found between both general and specific indexes and both cessation and reduction at one month. Although a greater change in smoking was seen at six months, few belief measures remained predictive. At one month, global measures were as useful as specific ones, although difficulty in situations of negative emotion was a consistent and strong predictor. Marked differences between the two sites were found; virtually no measure of difficulty proved predictive for the VA group.
- Published
- 1987
- Full Text
- View/download PDF
48. Phenothiazine-induced cholestatic jaundice.
- Author
-
Regal RE, Billi JE, and Glazer HM
- Subjects
- Cholestasis drug therapy, Cholestasis physiopathology, Humans, Phenothiazines, Risk Factors, Antipsychotic Agents adverse effects, Cholestasis chemically induced
- Abstract
Proposed mechanisms, clinical features, prevalence, and treatment of phenothiazine-induced cholestatic jaundice are reviewed, and interactions between phenothiazines and other drugs that could theoretically alter the risk of cholestasis are described. Phenothiazine-induced jaundice is classified as a form of cholestatic hepatocanalicular hepatotoxicity and as an acute liver disease. Occasionally cholestatic jaundice may progress to chronic liver disease. The mechanism of hepatotoxicity is not completely understood but may involve a combination of physiochemical, immune, and direct toxic effects. Based on proposed mechanisms, concomitant use of drugs that alter microsomal hepatic enzyme function or have metabolic pathways that interfere with or overlap with those of the phenothiazines could be expected to potentiate or reduce the risk of cholestasis. The estimated prevalence of jaundice with chlorpromazine is 1-2%. The prevalence of jaundice with other phenothiazines is probably similar. The onset of jaundice usually occurs during the first one to four weeks of therapy. In most cases, discontinuation of the offending drug is the only treatment required. Jaundice usually resolves without sequelae two to eight weeks later. Pruritus can be relieved by topical corticosteroid or analgesic therapies or by oral antihistamines or bile acid sequestrants if topical therapy is ineffective. Whenever possible, reinstitution of neuroleptic therapy should be delayed until the reaction has resolved. Selection of a nonphenothiazine neuroleptic agent may be preferred. Phenothiazine-induced cholestatic jaundice occurs relatively infrequently and is usually self-limited; topical agents and oral antihistamines can alleviate the discomfort associated with the reaction.
- Published
- 1987
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.