1. Comparative study of cefixime and tetracycline as an evaluation policy driven by the antibiotic resistance crisis in Indonesia.
- Author
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Ramdhani D, Kusuma SAF, Sediana D, Bima APH, and Khumairoh I
- Subjects
- Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents therapeutic use, Bordetella drug effects, Cefixime administration & dosage, Cefixime therapeutic use, Corynebacterium drug effects, Disk Diffusion Antimicrobial Tests, Drug Dosage Calculations, Haemophilus drug effects, Humans, Respiratory Tract Infections epidemiology, Respiratory Tract Infections microbiology, Staphylococcus drug effects, Streptococcus drug effects, Tetracycline administration & dosage, Tetracycline therapeutic use, Anti-Bacterial Agents toxicity, Cefixime toxicity, Drug Resistance, Bacterial, Respiratory Tract Infections drug therapy, Tetracycline toxicity
- Abstract
Antibiotic resistance is a serious threat that occurs globally in the health sector due to increased consumption of inappropriate antibiotics. Guidelines for prescribing antibiotics for ARTIs have been issued in general practice to promote rational antibiotic prescribing. This study was conducted to compare the effectiveness of cefixime and tetracycline as a solution to improve monitoring of appropriate antibiotic use in the treatment of ARTIs. All stock isolates were rejuvenated first, and cultured on standard media and Kirby-Bauer disc diffusion method was used for susceptibility testing in accordance with the Clinical and Laboratory Standard Institute's (CLSI) recommendations. Identification of bacteria from a single isolate was carried out to determine which bacteria were resistant to cefixime and tetracycline. A total of 466 single isolates of bacteria were analyzed, which showed a percentage of resistance to cefixime 38.0%, and tetracycline 92.86%. Bacterial isolates were resistant to cefixime and tetracycilne was a genus of Haemophilus, Streptococcus, Corynebacterium, Staphylococcus, and bordetella. Cefixime compared to tetracycline was proven to be superior in terms of the effectiveness of ARIs treatment., (© 2021. The Author(s).)
- Published
- 2021
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